Relevant bibliographies by topics / Cinnoline

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Cinnoline'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Cinnoline"

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Devlin, Jonathan, Richard Clogher, and Marcus Baumann. "Synthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline Derivatives." Synlett 31, no. 05 (2019): 487–91. http://dx.doi.org/10.1055/s-0039-1690752.

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Starting from phenylhydrazine and glucose, a versatile cinnoline scaffold was obtained on a multigram scale and further derivatized. A simple continuous-flow hydrogenation process permits the conversion of selected cinnolines into their 1,4-dihydrocinnoline counterparts. These products are generated in high yields and high purities with residence times of less than one minute and, along with their cinnoline precursors, are expected to serve as valuable heterocyclic building blocks for future medicinal chemistry programs.
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Sadek, Kamal Usef, Ramadan Ahmed Mekheimer, and Mohamed Abd-Elmonem. "Recent Developments in the Synthesis of Cinnoline Derivatives." Mini-Reviews in Organic Chemistry 16, no. 6 (2019): 578–88. http://dx.doi.org/10.2174/1570193x15666180712124148.

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Crinnolines can serve as unique and versatile class of heterocycles especially in fields related to synthetic and pharmaceutical chemistry owing to their potent biological activities. They possess diversity of pharmaceutical activities as anticancer, antibacterial, anti-inflammatory, anti-allergic as well as anti-hypertensive activities. Since the first synthesis of cinnoline by Richter (1883) numerous protocols for their synthesis have been developed utilizing arenediazonium salts, aryl hydrazines and arylhydhydrazones precursors. Recently metal catalyzed C-C and C-N bond formation reactions
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Tonk, Rajiv K., Sandhya Bawa, and Deepak Kumar. "Therapeutic Potential of Cinnoline Core: A Comprehensive Review." Mini-Reviews in Medicinal Chemistry 20, no. 3 (2020): 196–218. http://dx.doi.org/10.2174/1389557519666191011095858.

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Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers the principle approaches to the synthesis of cinnoline nucleus and almost all biologica
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Szumilak, Marta, and Andrzej Stanczak. "Cinnoline Scaffold—A Molecular Heart of Medicinal Chemistry?" Molecules 24, no. 12 (2019): 2271. http://dx.doi.org/10.3390/molecules24122271.

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The cinnoline nucleus is a very important bicyclic heterocycle that is used as the structural subunit of many compounds with interesting pharmaceutical properties. Cinnoline derivatives exhibit broad spectrum of pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, analgesic, anxiolytic and antitumor activities. Some of them are under evaluation in clinical trials. In the present review, we have compiled studies focused on the biological properties of cinnoline derivatives conducted by many research groups worldwide between 2005 and 2019. Comprehensive
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Danilkina, Natalia A., Petr S. Vlasov, Semen M. Vodianik, Andrey A. Kruchinin, Yuri G. Vlasov, and Irina A. Balova. "Synthesis and chemosensing properties of cinnoline-containing poly(arylene ethynylene)s." Beilstein Journal of Organic Chemistry 11 (March 20, 2015): 373–84. http://dx.doi.org/10.3762/bjoc.11.43.

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Novel poly(arylene ethynylene)s comprising a cinnoline core were prepared in high yields via a three-step methodology. A Richter-type cyclization of 2-ethynyl- and 2-(buta-1,3-diynyl)aryltriazenes was used for cinnoline ring formation, followed by a Sonogashira coupling for the introduction of trimethylsilylethynyl moieties and a sila-Sonogashira coupling as the polycondensation technique. The fluorescence of the cinnoline-containing polymers in THF was highly sensitive to quenching by Pd2+ ions.
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Danilkina, Natalia A., Ekaterina V. Andrievskaya, Anna V. Vasileva, et al. "4-Azidocinnoline—Cinnoline-4-amine Pair as a New Fluorogenic and Fluorochromic Environment-Sensitive Probe." Molecules 26, no. 24 (2021): 7460. http://dx.doi.org/10.3390/molecules26247460.

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A new type of fluorogenic and fluorochromic probe based on the reduction of weakly fluorescent 4-azido-6-(4-cyanophenyl)cinnoline to the corresponding fluorescent cinnoline-4-amine was developed. We found that the fluorescence of 6-(4-cyanophenyl)cinnoline-4-amine is strongly affected by the nature of the solvent. The fluorogenic effect for the amine was detected in polar solvents with the strongest fluorescence increase in water. The environment-sensitive fluorogenic properties of cinnoline-4-amine in water were explained as a combination of two types of fluorescence mechanisms: aggregation-i
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Dr. M.Rajasekaran, Dr M. Rajasekaran, H. B. Nihal Furkhan H.B.Nihal Furkhan, R. Nishanth R.Nishanth, N. Panneerselvam N.Panneerselvam, B. S. Nithishkumar B.S.Nithishkumar, and M. Pandiyan M.Pandiyan. "Synthesis and Docking Studies of Cinnoline Derivatives for Enhanced Anti-Bacterial Activity." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1797–815. https://doi.org/10.35629/4494-100217971815.

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This study involves the synthesis and evaluation of a series of cinnoline derivatives for their biological activities. The compounds were synthesized through a multi-step process, including the preparation of benzene diazonium chloride, formation of phenyl hydrazoneacetylacetone, synthesis of 4-methyl-3-acetyl cinnoline, and subsequent reactions with various amines. These compounds were characterized using Thin Layer Chromatography (TLC), melting point determination, solubility tests, and advanced spectroscopic techniques, including Infrared (IR) and Proton Nuclear Magnetic Resonance (1HNMR) s
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Fischer, Hans, Claus Krieger, and Franz A. Neugebauer. "Benzo[c]benzo[3,4]cinnolino[1,2-a]cinnoline, a Chiral Hydrazine Derivative." Angewandte Chemie International Edition in English 25, no. 4 (1986): 374–75. http://dx.doi.org/10.1002/anie.198603741.

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Bell, AJ, and RW Read. "Synthesis of Polynitro-Substituted 2'-Nitrobiphenyl-2-Amines, Analogs of Polynitro Benzo[c]cinnoline Oxide Derivatives." Australian Journal of Chemistry 40, no. 11 (1987): 1813. http://dx.doi.org/10.1071/ch9871813.

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2',3,4',5- and 2',3,5,6'-Tetranitrobiphenyl-2-amines, and 2',3,4',5,6'- and 2',4,4',6,6'-pentanitrobiphenyl-2-amines, have been synthesized for the first time, along with the known 2,4,8- and 2,4,10-trinitrobenzo[c]cinnoline 6-oxides and 1,3,7,9-tetranitrobenzo [c]cinnoline 5- oxide. The benzocinnoline oxide derivatives were found to have higher densities and thermal stability than those of the corresponding biphenylamines. These observations are discussed in terms of structure.
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Mandouma, Ghislain R., Tahera Nembhard, and Brittney Bender. "Synthesis of 2,3-dimethoxy-8,10-methylenedioxy benzo[c]cinnoline 7 As Potential Topoisomerase I Inhibitor." International Journal for Innovation Education and Research 4, no. 12 (2016): 56–77. http://dx.doi.org/10.31686/ijier.vol4.iss12.50.

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A novel and green synthesis of 2,3-dimethoxy-8,10-methylenedioxy benzo[c]cinnoline 7 is herein described. This compound is structurally related to benzo[i]phenanthridine, a class of potent topoisomerase I inhibitors such as nitidine. While nitidine was found to be toxic, the benzo[c]cinnoline derivative 7 may circumvent that by not being a Schiff base. A conveniently short synthetic plan was implemented involving a novel solvent- and catalyst-free cross-coupling biarylation of halogenated nitroarenes 2 and 5 using a high speed ball milling (HSBM) procedure. Indeed, using a copper vial as react
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Dissertations / Theses on the topic "Cinnoline"

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Scobie, Martin. "Investigations of new synthetic routes to cinnoline and fused cinnoline derivatives." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/14364.

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The subject matter of this thesis is concerned with the investigation of new synthetic routes to cinnoline and fused cinnoline derivatives. A description of the results obtained in these studies is preceded in Chapter 1 by a survey of literature methods for the synthesis of cinnoline derivatives. Chapter 2 describes an investigation into the use of 2-nitroaroylformimidates as intermediates in the synthesis of 3,4-substituted cinnoline derivatives and in particular 2-amino-3-(2-nitroaryl)quinoxalines. The base-catalysed cyclisation of the latter compounds, to afford quinoxalino[2,3-<i>c</i>]cin
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Gonska, Hedwig Ute. "Neue Pyrimido[5,4-c]cinnoline mit gerinnungsphysiologischer Aktivität." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/129/index.html.

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Voelk, Eric K. "Synthesis of 3,8-dicarbethoxyamino-2,4,7,9-tetrafluorophenanthridine and 3,8-dicarbethoxyamino-2,4,7,9-tetrafluorobenzo(c)cinnoline /." Connect to this title online, 1987. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1106769279.

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Tallon, Valérie. "Fonctionnalisation des quinoxalines et des cinnolines par réaction d'ortho-métallation." Rouen, 1996. http://www.theses.fr/1996ROUES041.

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La préparation de plusieurs quinoxalines et cinnolines, et en particulier une nouvelle synthèse de la 4-hydroxycinnoline ont été réalisées. Ce travail décrit la fonctionnalisation de la partie hétérocyclique de diverses quinoxalines et cinnolines par la réaction de métallation. La possibilité de métallation sur le cycle benzénique, en péri de l'azote, a aussi été montrée sur les cinnolines, avec l'iode et le chlorure de triméthylsilyle comme électrophiles. Enfin l'interêt de cette réaction de métallation est illustré par la préparation de xanthones et de diazépines.
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Leow, M. L. "Synthesis and pyrolysis of fused cinnolines related to dibenzobutalene." Thesis, University of Sunderland, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355596.

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Gautheron-Chapoulaud, Valérie. "Etude de la métallation du cycle benzénique de benzodiazines. Synthèse de composés aux propriétés électro-optiques. Synthèse d'un aza-BINAP." Rouen, 1998. http://www.theses.fr/1998ROUES082.

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Nous avons réalisé et mis au point la première fonctionnalisation via la réaction de lithiation du cycle benzénique de quinazolines, de quinoxalines et de phtalazines. Nous avons pu mettre en évidence une régiosélectivité quasi totale de cette réaction en position péri d'un atome d'azote cyclique. Grâce à la réaction de l'espèce lithiée avec une grande variété d'électrophiles, nous avons pu obtenir de nombreux nouveaux dérivés de benzodiazines difficilement accessibles, voire impossibles à préparer, par les méthodes traditionnelles. Nous avons appliqué cette méthode à la synthèse de diverses b
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Pearson, N. D. "Routes to hetareno[c]cinnolines as possible precursors to heteroaromatic analogues of biphenylene." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375028.

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Jurberg, Igor Dias. "Synthesis of Alkynes and New Transformations Catalyzed by Gold(I) Complexes." Palaiseau, Ecole polytechnique, 2010. http://pastel.archives-ouvertes.fr/docs/00/57/00/64/PDF/These_Igor.pdf.

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Sur la plateforme de thèses en ligne Tel on trouve le résumé suivant en français : La synthèse d'alcynes en utilisant des isoxazolones comme précurseurs a été une méthode développée dans notre laboratoire dans ler dernières années. Nous avons appliqué cette méthodologie pour la synthèse de 3-alkynylamides et leur utilisation pour générer des dihydropyrrolones. Nous avons aussi développé de nouvelles réactions catalysées pour complexes d'or(I): la synthèse de 4-oxazol-2-ones à partir de Boc-ynamides, une séquence de transfert 1,5 d'hydrure et cyclisation pour former des éther cycliques et la fo
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El, Marrouki Dalel. "Contribution à l’étude de la réactivité de quelques accepteurs de Michael cycliques et applications." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0197.

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Ce mémoire de thèse se concentre sur la synthèse d’hétérocycles azotés à partir d’une même famille de précurseurs : les 1,4-dicétones. Ces dernières ont été obtenues à travers deux voies de synthèse dont la première consiste en une réaction de Nef permettant la conversion des composés nitrés en cétones. La deuxième est une réaction de Wittig en utilisant divers ylures de Wittig et la cyclohexanedione. Ces intermédiaires réactionnels ont été utilisés par la suite pour la synthèse de dérivés indoliques via une réaction d’addition-1,2. Nous avons également pu orienter la sélectivité de la réactio
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Stern, Eric. "Nouveaux agonistes des récepteurs aux cannabinoïdes CB², dérivés de 4-oxo-quinoléines, 4-oxo-naphtyridines et 4-oxo-cinnolines." Lille 2, 2006. http://www.theses.fr/2006LIL2S013.

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Le cancer, deuxième cause de mortalité et de morbidité dans les pays développés après les maladies cardio-vasculaires, résulte d'un dérèglement du programme génétique de la cellule conduisant à son immortalité et à une prolifération anarchique. En France en 2004, 40 000 nouveaux cas de cancer de la prostate ont été diagnostiqués. Le cancer de la prostate touche an général le sujet âgé et représente la deuxième cause de décès par cancer chez l'homme, après le cancer du poumon. Du fait du vieillissement de la population des pays développés, le nombre de patients atteints par le cancer de la pros
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Books on the topic "Cinnoline"

1

Brown, D. J. Cinnolines and Phthalazines. John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0471744123.

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Cinnolines and Phthalazines. Wiley & Sons Canada, Limited, John, 2005.

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Taylor, Edward C., Desmond J. Brown, and Jonathan A. Ellman. Cinnolines and Phthalazines, Supplement 2. Wiley & Sons, Incorporated, John, 2005.

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Cinnolines and phthalazines: Supplement 2. Wiley, 2005.

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Castle, Raymond N. Condensed Pyridazines Including Cinnolines and Phthalazines. Wiley & Sons, Incorporated, John, 2009.

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Taylor, Edward C., Desmond J. Brown, and Jonathan A. Ellman. Cinnolines and Phthalazines, Volume 64, Supplement 2. Wiley & Sons Australia, Limited, John, 2005.

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Simpson, J. C. Pyridazine and Pyrazine Rings : (Cinnolines, Phthalazines, and Quinoxalines). Wiley & Sons, Incorporated, John, 2009.

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Castle, Raymond N. Chemistry of Heterocyclic Compounds, Condensed Pyridazines Including Cinnolines and Phthalazines. Wiley & Sons, Incorporated, John, 2008.

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Taylor, Edward C., Peter Wipf, and Desmond J. Brown. Cinnolines and Phthalazines: Chemistry of Heterocyclic Compounds, Supplement II (Chemistry of Heterocyclic Compounds: A Series Of Monographs). Wiley-Interscience, 2005.

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Book chapters on the topic "Cinnoline"

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Horkel, Ernst. "Metalation of Pyridazine, Cinnoline, and Phthalazine." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/7081_2012_97.

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Singerman, Gary M. "Cinnolines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186978.ch1.

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Główka, Marek L., Dariusz Martynowski, Andrzej Olczak, and Alina Staszewska. "Cinnoline Analogs of Quinolones: Structural Consequences of the N Atom Introduction in the Position 2." In Molecular Modeling and Prediction of Bioactivity. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4141-7_50.

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Chandra, H., H. Fischer, F. A. Neugebauer, and M. C. R. Symons. "Radical Ions of Benzo[c]cinnolines and 2,3-Dihydro-1H-benzo[c]pyrazolo[1,2-a]cinnolines." In Organic Free Radicals. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73963-7_71.

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Rowlands, C. C., and R. D. Farley. "15.6.2 Benzo[c]cinnolines and azobenzene derivatives." In Landolt-Börnstein - Group II Molecules and Radicals. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-45824-1_51.

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Saini, Pratibha, Krishan Kumar, Swati Meena, et al. "An Overview of Cinnolines, Quinazolines and Quinoxalines: Synthesis and Pharmacological Significance." In N-Heterocycles. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-0832-3_9.

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"cinnoline, n." In Oxford English Dictionary, 3rd ed. Oxford University Press, 2023. http://dx.doi.org/10.1093/oed/5684312886.

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"Cinnoline Quaternary Salts." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.ch7.

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"General Introduction to Cinnoline Derivatives. Preparation and Properties of Cinnoline." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.ch1.

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"Appendix I. Ultraviolet Absorption Spectra of Cinnoline and Quinoxaline Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.app1.

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Conference papers on the topic "Cinnoline"

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Butin, Alexander, Vladimir Abaev, Tat'yana Stroganova, Andrey Gutnov, Irina Lodina, and Olga Shurakova. "Indole, Cinnoline, Benzothiazine and Dihydrofuroquinoline Derivatives from Aryldifurylmethanes." In The 3rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1999. http://dx.doi.org/10.3390/ecsoc-3-01715.

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