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Dissertations / Theses on the topic 'Circadian cycles'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Bee, Leonardo. "DNA Repair is Modulated by Cellular and Circadian Cycles." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423792.

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DNA repair is an essential cellular function aiming to maintain genomic stability during dangerous environmental conditions, such as exposure to UV light and ionizing radiation. At the molecular level, cell life is marked by rhythmic events resulting from the two major oscillatory systems: the circadian clock and the cell cycle, which share some striking similarities. Both consist of interlocked auto-regulatory feedback loops and both rely on chromatin remodeling events that produce sequential transcription, translation, post-translational modification, and degradation phases. In mammals, DNA

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2

Cretenet, Gaspard. "Coordination par l'horloge circadienne de l'activation rythmique du stress du RE et de la traduction dans le foie de souris." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20115/document.

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En premier lieu, l'horloge circadienne des mammifères joue un rôle fondamental dans le foie en régulant le métabolisme des acides gras, du glucose et des xénobiotiques. L'altération de ce rythme a été montrée comme menant à diverses pathologies incluant le syndrome métabolique. Il est supposé que l'horloge circadienne régule principalement le métabolisme en régulant l'expression des enzymes hépatiques au niveau transcriptionnel. Nous montrons que l'horloge circadienne contrôle au ssi le métabolisme hépatique en synchronisant un rythme secondaire d'une période de 12 heures caractérisé par l'act

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3

Saiphon, Kongkum. "The effect of the circadian and menstrual cycles on cardiovascular and thermoregulatory responses to exercise." Thesis, Liverpool John Moores University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572050.

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Many physiological variables exhibit circadian rhythmicity. The circadian rhythm in core temperature is a well-established and it has been extensively studied during both passive and exercise heat exposure. In females, a circamensal rhythm in core temperature is also present and well established. However, there is little knowledge about whether there is an interaction effect between time of day and phase of menstrual cycle on core temperature and thermoregulatory and cardiovascular responses during and following exercise. The studies in the present thesis were designed to investigate such an i

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4

De, Caluwe Joelle. "Modeling the plant circadian clock: a study of light, photoperiodism, and growth." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/251373.

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Le travail présenté dans cette thèse consiste en la création et l'étude des propriétés d'un nouveau modèle computationnel de l'horloge circadienne végétale et de certains processus physiologiques qui en dépendent.L'horloge circadienne est un rythme endogène d'une période d'environ 24 heures que possèdent la plupart des êtres vivants. Il est généré au niveau moléculaire par des boucles de rétroaction transcriptionnelles, traductionnelles et/ou post-traductionnelles. L'horloge permet aux organismes de s'a- dapter à leur environnement. L'horloge des plantes se distingue par un nombre important de

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5

Behaegel, Jonathan. "Modèles hybrides de réseaux de régulation : étude du couplage des cycles cellulaire et circadien." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4071/document.

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La modélisation de systèmes biologiques est devenue indispensable pour comprendre les phénomènes complexes et émergents issus d'influences partiellement connues, et pour envisager de contrôler un système altéré dans le but de restaurer un comportement physiologique. Tout modèle, quel que soit son paradigme sous-jacent, fait intervenir des paramètres gouvernant sa dynamique mais les mesures expérimentales ne permettent généralement pas de les identifier et cela reste l'un des problèmes majeurs de la modélisation. Cette thèse propose une méthode automatique d'identification des paramètres dynami

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6

Desvergne, Audrey. "Le protéasome et l'immunoprotéasome : cibles thérapeutiques et implication dans la modulation circadienne de l'accumulation des protéines carbonylées." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066308.

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Le protéasome et l’immunoprotéasome possèdent trois activités catalytiques différentes et dégradent une grande variété de protéines. Leur rôle central dans de nombreux processus tels que le contrôle du cycle cellulaire et circadien, la régulation des voies de défense contre le stress font d’eux des cibles majeures dans le processus de vieillissement et dans le traitement des cancers. Aussi, le lien établi entre l'horloge circadienne et les défenses anti-oxydantes suggère que l'homéostasie redox des protéines et leur élimination par le protéasome soient modulées par l'horloge circadienne. L’étu

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7

Nguyen, John Loc. "The effects of reversing sleep-wake cycles on sleep and fatigue on the crew of USS John C. Stennis." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2002. http://library.nps.navy.mil/uhtbin/hyperion-image/02sep%5FNguyen.pdf.

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Thesis (M.S. in Operations Research)--Naval Postgraduate School, September 2002.<br>Thesis advisor(s): Nita L. Miller, Samuel E. Buttrey, Susan M. Sanchez. Includes bibliographical references (p. 147-149). Also available online.

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8

Gagliano, Onelia. "Development of a "lab on a chip" platform for studying the control of the circadian clock by metabolic cycles." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424139.

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The aim of the thesis is developing an in vitro model that resembles the cyclic dynamic fluctuations that can be correlated to the pertinent biological networks for dissecting the effects the metabolism on circadian clock. The circadian rhythms are an adaptation to the evolutionarily conserved environment, because they allow to coordinate temporally external environmental cycles (eg. light/ dark) with internal biological and physiological processes (eg. sleep/ wake). Forced misalignment of behavioral and circadian cycles in human subjects, have been associated with increased prevalence of ob

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9

Desvergne, Audrey. "Le protéasome et l'immunoprotéasome : cibles thérapeutiques et implication dans la modulation circadienne de l'accumulation des protéines carbonylées." Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066308.

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Le protéasome et l’immunoprotéasome possèdent trois activités catalytiques différentes et dégradent une grande variété de protéines. Leur rôle central dans de nombreux processus tels que le contrôle du cycle cellulaire et circadien, la régulation des voies de défense contre le stress font d’eux des cibles majeures dans le processus de vieillissement et dans le traitement des cancers. Aussi, le lien établi entre l'horloge circadienne et les défenses anti-oxydantes suggère que l'homéostasie redox des protéines et leur élimination par le protéasome soient modulées par l'horloge circadienne. L’étu

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10

Sawyer, Tiffoney L. "The effects of reversing sleep-Wake cycles on mood states, sleep, and fatigue on the crew of the USS John C. Stennis /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Jun%5FSawyer.pdf.

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Thesis (M.S. in Applied Science (Operations Research))--Naval Postgraduate School, June 2004.<br>Thesis advisor(s): Nita Lewis Miller. Includes bibliographical references (p. 103-107). Also available online.

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11

Fung, Uceda Jorge Alberto. "Characterization of the circadian clock function in the control of cell cycle progression to modulate growth in Arabidopsis thaliana." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664286.

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La función circadiana es esencial para el crecimiento y adaptación de las plantas a su entorno. La maquinaria molecular responsable de la generación de ritmos circadianos está basada en la expresión rítmica de genes cuyo pico de expresión oscila en diferentes fases durante el día y la noche. Los ritmos de expresión génica se traducen en oscilaciones de procesos fisiológicos y de desarrollo. El crecimiento de las plantas está regulado por una plétora de procesos que en última instancia operan a través del control de la proliferación y diferenciación celular. La proliferación celular depende de

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12

Gauger, Michele Ann Sancar Aziz. "Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,971.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.

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13

Santos, Carlo Steven. "Circadian Control of Cell Cycle Progression." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/76987.

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Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint pathways involve a p53 dependent pathway which can trigger the cell to go through cell arrest or programmed cell death4. Understanding all the mitigating factors involved in regulating cell cycle progression under DNA damage can offer a better idea in how cells become immortal. Initially discovere

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14

Luitel, Prashant. "Protein localization during the cyanobacterial circadian cycle." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45432.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Physics, 2008.<br>Includes bibliographical references (p. 77-[78]).<br>Circadian clocks are ubiquitous throughout the living world. Of these circadian clocks, the simplest one is found in cyanobacteria - unicellular, photosynthetic marine organisms. Studies of the circadian clock of Synechococcus Elongatus PCC 7942 have shown that the circadian clock is independent of genetic transcription and depends only upon the interactions between three proteins - KaiA, KaiB, and KaiC. As such, the cyanobacterial circadian clock provides a uni

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15

Cox, C. A. "The circadian clock and the cell cycle." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1348317/.

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The circadian clock is an endogenous time-keeping mechanism that allows an organism to coordinate its biology with the 24 hour variations in its external environment. Epidemiological studies have linked clock disruption to an increase incidence of cancer, in particular breast malignancy. On a molecular level, clock components have been shown to regulate cell cycle gene expression and its progression in a number of models. This thesis set out to further dissect the link between these two important systems. Within the zebrafish cell-line, PAC2, mitosis was demonstrated to be under circadian cont

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16

Mteyrek, Ali. "Rôle de l’horloge circadienne dans la cancérisation hépatique expérimentale et sa prévention." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114801/document.

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L’agence internationale de recherche sur le cancer (IARC) a indiqué que le travail posté qui provoquait une disruption circadienne était probablement cancérogène chez l’Homme. Ainsi, une perturbation expérimentale sévère du système circadien accélère-t elle la progression tumorale et pourrait favoriser la cancérogénèse. Durant ma thèse, j’ai démontré que la disruption circadienne résultant d’une mutation ou d’une mise au silence des gènes de l’horloge Per ou Cry accélérait la cancérogénèse hépatique induite par la diéthylnitrosamine, en favorisant l’instabilité génomique, la prolifération cell

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17

Altinok, Atilla. "Modélisation du cycle cellulaire par un automate stochastique: application à la chronopharmacologie d'agents anticancéreux." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209876.

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Nous proposons un modèle d’automate pour le cycle cellulaire lié à l’horloge circadienne. Ce modèle est utilisé pour déterminer la toxicité de différents schémas d’administration d’agents anticancéreux selon un profil temporel déterminé, dans le but d’optimiser l’efficacité de la chronothérapie des cancers. Fondé sur les transitions séquentielles entre les phases successives du cycle cellulaire G1, S (réplication de l’ADN), G2 et M (mitose), le modèle permet de simuler la distribution des phases du cycle cellulaire et son entraînement par l’horloge circadienne. Le modèle est utilisé pour évalu

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18

Babar, Sandly. "Cross-talk between cell-cycle control and the environment." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00998938.

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Even though the understanding of cell-cycle regulators in plants has tremendously increased over the last years, still little is known about cell-cycle regulation in response to environmental signals like DNA damage. A ubiquitous stress for any organism is DNA stress that can either be caused by exogenous sources or internal processes like chromatid separation or DNA strands separation during replication. The posttranslational regulation of Cdk1-type kinases through inhibitory phosphorylation through Wee1-type kinases in the so-called P-loop at the residue Tyr15 or the analogous positions has

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19

Jenkins, H. A. "Circadian and ultradian rhythms in Chlamydomonas and Euglena." Thesis, Bucks New University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233011.

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20

Ragsdale, Raven, Colin Shone, Madeleine Miller, Andrew Shields, Thomas C. Jones, and Darrell Moore. "Circadian Resonance and Entrainment in Three Spider Species (Frontinella communis, Metazygia wittfeldae, and Cyclosa turbinata)." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/140.

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Circadian clocks are vital to the proper functioning of organisms’ internal processes and behavioral outputs and typically have endogenous periods that approximate (within 1-2 hours) the 24-hour solar day. Clocks that deviate significantly from about 24 hours are often associated with metabolic syndromes or other disease states. For instance, organisms with near-24-hour clocks have higher survivorship under 24-h light:dark (LD) cycles than with 22- or 26-hour cycles. Likewise, mutant organisms with 22-hour clocks survive better under 22-h cycles but fare poorly under 24- and 26-h cycles. In ot

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21

Haynes, Patricia L. "Circadian impact of psychosocial factors in depression /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3094609.

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22

Rochon, Paul. "Rythme de la vigilance et de la cognition." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21782/document.

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Le thème de notre thèse porte sur les rythmes de la vigilance et de la cognition. La première partie porte sur la validation d’échelles subjectives étalonnées sur des tests itératifs de latence d’endormissement. Une analyse factorielle des résultats identifie au moins trois sous catégories de la vigilance (ergique ou comportementale, cognitive, émotionnelle). Ensuite, les rythmes chronologiques de ces trois dimensions sont mesurés avec les variations circadiennes sur vingt-cinq heures de la température centrale et lors d’une modification provoquée d’état de conscience (hypnose). La variation d

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23

Sousa, Jucilene Pereira de. "Peixe-zebra (Danio rerio) Transgênico para o gene bmal1a: efeitos no relógio molecular do músculo esquelético." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/8838.

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Submitted by Maike Costa (maiksebas@gmail.com) on 2017-02-17T12:43:01Z No. of bitstreams: 1 rquivo total.pdf: 1353702 bytes, checksum: 83db724c3c959a4e1d35f4040336484d (MD5)<br>Made available in DSpace on 2017-02-17T12:43:01Z (GMT). No. of bitstreams: 1 rquivo total.pdf: 1353702 bytes, checksum: 83db724c3c959a4e1d35f4040336484d (MD5) Previous issue date: 2016-11-28<br>Most organisms have circadian rhythms with a periodicity of 24-hour that are generated by an endogenous mechanism, the molecular clock, which has the ability to synchronize biological functions with environmental signals. T

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Yu, Xiao. "Histamine at the intersection of the sleep-wake cycle and circadian rhythms." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/26596.

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Histamine is central in sleep-wake regulation. First, I mapped the distribution of histamine producing neurons in the adult brain using genetic approaches. Second, to further explore the histaminergic system, I found that a local circadian clock regulates the expression of histidine decarboxylase (HDC), the enzyme producing histamine in hypothalamic neurons. The level of this enzyme varies with time of day and is up-regulated by sleep deprivation. I disrupted this local clock by using HDC-Cre recombinase by deleting BMAL1, the transciption factor central to circadian rhythms, selectively in hi

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Laranjeiro, R. F. F. "Circadian clock regulation of the zebrafish cell cycle and developmental gene expression." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1421149/.

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The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great deal is known about key developmental events, but also because of the highly decentralised nature of its circadian system. Moreover, specific stages of the cell cycle are clock-controlled in zebrafish cell lines and during embryo development, making zebrafish an ideal model to explore the interactions between these two cellular oscillators. This

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Grácio, Ana Rita Pereira. "Diel variation in movement patterns and habitat use by the near-threatened cabrera vole in mediterranean farmland." Master's thesis, Universidade de Évora, 2016. http://hdl.handle.net/10174/18612.

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As variações circadianas no comportamento animal e o seu impacto nas populações constituem desafios importantes em ecologia e conservação. Nesta tese documentam-se as variações circadianas no uso do habitat e padrões de movimento pelo rato de Cabrera, em habitats Mediterrânicos fragmentados. O estudo baseou-se no radio-seguimento de indivíduos em habitats dominados por herbáceas e arbustos. Os resultados indicaram que a proporção de tempo despendido em deslocações, a distância percorrida, e a selecção do tipo de vegetação, estão fortemente interrelacionados, variando consideravelmente ao longo

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27

Yin, Weiwei. "A Mathematical Model of the Sleep-Wake Cycle." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14508.

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The daily sleep-wake cycle usually consists of three distinct states: wakefulness, non-rapid-eye-movement (NREM) and rapid-eye-movement (REM). The process of switching between different states is complex, but a common assumption is that it is regulated primarily by two processes (the circadian and the homeostatic process) via reciprocal interactions of several downstream neuron groups. These interactions not only result in often rapid transitions from one state to another, but also allow for a certain degree of bi-stability that locks the organism in a given state for some while before it swi

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Grow, Brian J. Sullivan Matthew C. "Assessing the effect of shipboard motion and sleep surface on sleep effectiveness." Monterey, California : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Dec/09Dec%5FGrow.pdf.

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Thesis (M.S. in Human Systems Integration)--Naval Postgraduate School, December 2009.<br>Thesis Advisor(s): Miller, Nita Lewis. Second Reader: McCauley, Michael E. "December 2009." Description based on title screen as viewed on January 26, 2010. Author(s) subject terms: Sleep Efficiency, Sleeping Surface, Acceleration, Motion Effects on Sleep, Actigraphy, Sleep Quality, Shipboard Sleep. Includes bibliographical references (p. 83-87). Also available in print.

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Sayer, Tamsin. "Variation in central serotoninergic 5-HT1B function through the light-dark cycle : effect of chronic antidepressant treatment." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239953.

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Albertoni, Fabiano Fabian. "Análise faunística de Saturniidae (Insecta, Lepidoptera) em fragmento de Mata Atlântica do Estado de São Paulo, Brasil." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/38/38131/tde-26112014-170238/.

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O presente estudo listou e analisou a composição e a estrutura da comunidade de saturnídeos atraídos por luz da Estação Biológica de Boraceia (EBB), Salesóplis, São Paulo, Brasil. A EBB pertence ao Museu de Zoologia da Universidade de São Paulo (MZUSP) e compreende uma área de 96 ha, por sua vez localizada dentro do maior remanescente brasileiro de Mata Atlântica da atualidade. A fauna de Saturniidae foi levantada através de exemplares da coleção de Lepidoptera do MZUSP, sendo estes dados complementados com 13 meses de coletas recentes, entre 2012 e 2013, quando foram realizadas coletas noturn

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Thind, Raja Mandeep Singh. "BRIEF CONSTANT LIGHT ACCELERATION OF NONPHOTIC CIRCADIAN PHASE SHIFTING AND REENTRAINMENT OF LD CYCLE." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1270764667.

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El, Cheikh Raouf. "Multiscale modeling for the regulation of cell cycle by the circadian clock : applications to chronotherapy." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10082/document.

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Cette thèse est dédiée au développement d’un modèle mathématique multi-échelle pour la régulation du cycle cellulaire par l’horloge circadienne. Ceci est motivé par le fait que plusieurs études ont montré un lien direct entre certains cancers et un dysfonctionnement du mécanisme de l’horloge circadienne. Le but est de comprendre l’effet des rythmes circadiens et leur perturbation sur la prolifération d’une population de cellules<br>This thesis is dedicated to the development of a multiscale mathematical model that describes the regulation of the cell cycle by the circadian clock. What motivate

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Marçola, Marina. "Perfil circadiano da expressão de microRNAs em células progenitoras CD133+." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-19052015-092113/.

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Culturas de células primárias diferem de acordo com as condições ambientais nas quais se encontra o doador. Recentemente demonstramos que o ciclo claro/escuro impõe um programa molecular hereditário em cultura celular. Com o intuito de investigar os mecanismos moleculares da memória celular, no presente trabalho isolamos células progenitoras CD133+ de explante de músculo cremaster e investigamos se a expressão de microRNAs (miRNAs), resulta em fenótipos diferentes de acordo com o ciclo claro/escuro. O sequenciamento global de miRNAs utilizando a plataforma SOLiD 4 e analisado pelos programas E

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Herrman, Erin Rae. "Estrous Cyclicity Modulates Circadian Rhythms In Female Syrian Hamsters." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1228154599.

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Carvalho, Maria Raquel de. ""Sincronização da atividade locomotora em robalos juvenis (Centropomus parallelus e C. undecimalis) pelo ciclo claro/escuro e ciclo de disponibilidade alimentar"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/21/21131/tde-19092006-093049/.

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Os peixes são organismos plásticos em relação às alterações de ciclos ambientais como o ciclo claro/escuro e ciclo de disponibildade alimentar, zeitgebers comprovadamente fortes para outros organismos vertebrados. O objetivo geral deste estudo foi verificar se o ciclo claro /escuro (CE) e o ciclo de disponibilidade alimentar (AJ) promovem sincronização da atividade locomotora em exemplares de robalos juvenis das espécies Centropomus parallelus e C. undecimalis coletados na região do Sistema Cananéia-Iguape (SP). Foi verificada uma possível relação hierárquica entre estes ciclos ambientais, e t

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Cubitt, Tania Anne. "Long Term and Short Term Changes in Leptin, Insulin and Glucose in Grazing Thoroughbred Mares." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29807.

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The objective was to evaluate the insulin-leptin interactions in grazing mares and their impact on aspects of reproductive function using a series of four studies. Fourteen mares were first examined, 10 grazing and 4 confined to stalls in four 22-h studies in April, August, October (2005) and January (2006). There was a positive relationship between insulin and leptin concentrations (r = 0.50; P < 0.001). The second study used 24 mares maintained at pasture and fed supplements rich in either FF, or SS, or pasture forage. Nonstructural carbohydrate (NSC) content of forage was correlated to

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Amdaoud, Malika. "Stabilité du rythme circadien des cyanobactéries : investigation d’un couplage entre oscillateurs." Phd thesis, Grenoble 1, 2007. http://www.theses.fr/2007GRE10051.

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Chez la majorité des organismes vivants, depuis certaines bactéries, jusqu’aux mammifères, de nombreux processus biologiques sont rythmés, comme par exemple l’alternance veille sommeil, ou encore le cycle d’hibernation. Le contrôle de ces rythmes biologiques est effectué grâce à des horloges biologiques, qui sont dans certains cas des oscillateurs auto-entretenus programmés génétiquement. Les oscillateurs biologiques dont la période est de proche de 24h sont dits circadiens. La cyanobactérie Synechoccocus elongatus sp. PCC7942 est l’un des plus simples organismes possédant cette horloge circad

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LACERDA, Carlos Henrique Figueiredo. "A Importância das praias para o desenvolvimento inicial de assembleias de peixes e macrocrustáceos: variação espaço-temporal da ictiofauna em praias adjacentes a um estuário tropical (Resex Acaú-Goina PE/PB, Brasil)." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/18855.

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Submitted by Caroline Falcao (caroline.rfalcao@ufpe.br) on 2017-05-22T17:05:47Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Tese_Lacerda2014 (versão BC).pdf: 15671958 bytes, checksum: bd96e677f6b27688458828455de7708d (MD5)<br>Made available in DSpace on 2017-05-22T17:05:47Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Tese_Lacerda2014 (versão BC).pdf: 15671958 bytes, checksum: bd96e677f6b27688458828455de7708d (MD5) Previous issue date: 2014<br>As zonas costeiras são consideradas áreas

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Traynard, Pauline. "Model Building by Temporal Logic Constraint Solving : Investigation of the Coupling between the Cell Cycle and the Circadian Clock." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC087.

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Cette dissertation explore l'utilisation de la logique temporelle et de la vérification de modèle en biologie des systèmes. Nous soutenons que la logique temporalle constitue un outil puissant pour formaliser des propriétés dynamiques à la fois complexes et imprécises permettant de caractériser un système biologique. Cet outil peut être utilisé pour partiellement automatiser la construction de modèle, comme une résolution d'un problème de satisfaction de contraintes. Tout d'abord, nous étudions l'emploi de la logique arborecente (Computation Tree Logic) pour vérifier des propriétés dynamiques

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Mahan, Kristin Lynn. "Circadian oscillation of MAPK activity and cAMP in the hippocampus : implications for memory persistence /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/6304.

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Peffers, Caitlin Skye. "Investigating Seasonal Responses in the Northern House Mosquito, Culex pipiens." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619111174458783.

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YE, Shiqi. "The role of methyl cycle and N6-methyladenosine in the regulation of biological clock." Kyoto University, 2019. http://hdl.handle.net/2433/244527.

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要約ファイル未提出(2019.11.01)→要約ファイル提出(2020.07.31)<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(薬科学)<br>甲第22046号<br>薬科博第112号<br>新制||薬科||12(附属図書館)<br>京都大学大学院薬学研究科医薬創成情報科学専攻<br>(主査)教授土居雅夫, 准教授 Fustin,Jean Michel, 教授中山和久<br>学位規則第4条第1項該当

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Sallanon, Marcelle. "Régulations hypothalamiques et hypophysaires du cycle veille-sommeil et leurs contrôles par les indolamines." Lyon 1, 1989. http://www.theses.fr/1989LYO19006.

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Nous avons etudie les regulations hypothalamiques et hypophysaires du cycle veille/sommeil et leurs controles par les indolamines, chez le chat. L'hypophyse, le noyau paraventriculaire et le noyau arque (arc) ne sont pas des structures strictement necessaires a l'apparition du sommeil, mais certains peptides issus du arc et de l'hypophyse pourraient moduler l'alternance des etats de vigilance. De plus, la lesion des corps cellulaires neuronaux de l'hypothalamus ventrolateral posterieur (hvl) induit une hypersomnie intense et de courte duree ainsi qu'une hypothermie transitoire. D'autre part, l

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Teixeira, Ighor Luiz Azevedo. "Silenciamento dos genes fruitless e period: efeitos no comportamento locomotor e reprodutivo de Anastrepha sp.1 affinis fraterculus (Diptera, Tephritidae)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-02042018-113118/.

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O complexo de espécies crípticas de Anastrepha fraterculus compreende oito morfotipos dos quais três ocorrem no Brasil. Anastrepha sp.1 aff. fraterculus é o morfotipo Brasil-1 e é uma espécie de ampla distribuição no planalto sudeste/sul do Brasil e no norte da Argentina. O comportamento reprodutivo dessa espécie é complexo, envolvendo uma série de movimentos desempenhados pelos machos para atrair as fêmeas para acasalamento, e ocorre, preferencialmente, nas primeiras horas do dia. Dois genes, period e fruitless, entre outros, são conhecidos por participar do controle do comportamento reprod

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Bahougne, Thibault. "Perturbation de la rythmicité circadienne : impact sur la fonction reproductive de souris femelles." Thesis, Strasbourg, 2020. http://www.theses.fr/2020STRAJ001.

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Chez les mammifères femelles, la fonction reproductive dépend à la fois d’une horloge biologique synchronisée par le cycle lumière/obscurité et par un équilibre entre le rétrocontrôle négatif et positif des œstrogènes, dont les concentrations varient en fonction de la maturation folliculaire. Chez les femmes, un nombre croissant d’études signalent un impact négatif des environnements chronodisruptifs, comme le travail posté / de nuit, sur la fertilité. Les objectifs de mon travail étaient d’étudier les effets d’un décalage de phase unique ou chronique sur les cycles reproducteurs de souris (C5

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Laomettachit, Teeraphan. "Mathematical modeling approaches for dynamical analysis of protein regulatory networks with applications to the budding yeast cell cycle and the circadian rhythm in cyanobacteria." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/29492.

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Mathematical modeling has become increasingly popular as a tool to study regulatory interactions within gene-protein networks. From the modelerâ s perspective, two challenges arise in the process of building a mathematical model. First, the same regulatory network can be translated into different types of models at different levels of detail, and the modeler must choose an appropriate level to describe the network. Second, realistic regulatory networks are complicated due to the large number of biochemical species and interactions that govern any physiological process. Constructing and valida

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Mat, Audrey. "Étude des rythmes biologiques de l'huître Crassostrea gigas et de leur perturbation par l’algue toxique Alexandrium minutum." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14628/document.

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Les rythmes biologiques constituent une propriété fondamentale de la vie, permettant aux organismes d’appréhender leur environnement et d’en anticiper les changements. Ces rythmes possèdent une double origine : une horloge moléculaire génère ces rythmes, qui sont ensuite synchronisés par des facteurs environnementaux. Si les organismes terrestres sont essentiellement soumis au rythme d’alternance jour/nuit, les espèces marines côtières et estuariennes occupent un biotope plus changeant encore : ils sont en effet également confrontés au rythme des marées. Pourtant, leurs rythmes biologiques son

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Clodore, Martine. "La vigilance : evolution circadienne et horaires de sommeil, importance de la typologie matin/soir." Paris 6, 1988. http://www.theses.fr/1988PA066153.

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Crouzier, David. "Effets non thermiques des champs de radiofréquences sur le système nerveux central : étude multiparamétrique réalisée sur le rat vigile." Université Joseph Fourier (Grenoble), 2006. http://www.theses.fr/2006GRE10034.

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De nombreuses craintes sont aujourd'hui formulées quant à l'innocuité des champs de radiofréquences sur la santé. Parmi celles-ci des perturbations de la neurophysiologie et plus spécifiquement du système cholinergique central ont été évoquées. Un modèle d'étude multiparamétrique a été développé chez le rat vigile présentant à la fois un aspect électrophysiologique, neurochimique obtenu par microdialyse, comportemental par quantification des états de vigilance et thermophysiologique par le suivi de la température corporelle. Lors de l'exposition à un champ électromagnétique de 1,8 GHz ou 2,45

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Amoretty, Paulo Roberto de. "Análise dos ritmos circadianos de atividade locomotora de drosófilas transgênicas carregando o gene cycle do flebotomíneo lutzomyia longipalpis." reponame:Repositório Institucional da FIOCRUZ, 2010. https://www.arca.fiocruz.br/handle/icict/12022.

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Made available in DSpace on 2015-10-21T12:23:03Z (GMT). No. of bitstreams: 2 paulo_amoretty_ioc_mest_2010.pdf: 2975859 bytes, checksum: 06f8ce008cd108bb1b64d2c7a0ec4c5d (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015-05-21<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>O relógio circadiano, presente em diversos organismos, é um mecanismo que controla ritmos diários na fisiologia e comportamento, os quais são mantidos mesmo na ausência de estímulos externos. Estudos em Drosophila melanogaster revelar

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