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Journal articles on the topic 'Circadian cycles'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Usui, Setsuo, Terue Okazaki, and Yoshiko Honda. "Interruption of the rat circadian clock by short light-dark cycles." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284, no. 5 (2003): R1255—R1259. http://dx.doi.org/10.1152/ajpregu.00717.2002.

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Ninety male Sprague-Dawley rats were exposed to 1:1-h light-dark (LD1:1) cycles for 50–90 days, and then they were released into constant darkness (DD). During LD1:1 cycles, behavioral rhythms were gradually disintegrated, and circadian rhythms of locomotor activity, drinking, and urine 6-sulfatoxymelatonin excretion were eventually abolished. After release into DD, 44 (49%) rats showed arrhythmic behavior for >10 days. Seven (8%) animals that remained arrhythmic for >50 days in DD were exposed to brief light pulses or 12:12-h light-dark cycles, and then they restored their circadian rhy

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2

Price-Lloyd, N., M. Elvin, and C. Heintzen. "Synchronizing the Neurospora crassa circadian clock with the rhythmic environment." Biochemical Society Transactions 33, no. 5 (2005): 949–52. http://dx.doi.org/10.1042/bst0330949.

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The metronomic predictability of the environment has elicited strong selection pressures for the evolution of endogenous circadian clocks. Circadian clocks drive molecular and behavioural rhythms that approximate the 24 h periodicity of our environment. Found almost ubiquitously among phyla, circadian clocks allow preadaptation to rhythms concomitant with the natural cycles of the Earth. Cycles in light intensity and temperature for example act as important cues that couple circadian clocks to the environment via a process called entrainment. This review summarizes our current understanding of

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3

EDMUNDS, LELAND N., DANIELLE L. LAVAL-MARTIN, and KEN GOTO. "Cell Division Cycles and Circadian Clocks." Annals of the New York Academy of Sciences 503, no. 1 Endocytobiolo (1987): 459–75. http://dx.doi.org/10.1111/j.1749-6632.1987.tb40630.x.

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Dunlap, Jay C., Jennifer J. Loros, Yi Liu, and Susan K. Crosthwaite. "Eukaryotic circadian systems: cycles in common." Genes to Cells 4, no. 1 (1999): 01–10. http://dx.doi.org/10.1046/j.1365-2443.1999.00239.x.

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5

Ma, Huan, Luyao Li, Jie Yan, et al. "The Resonance and Adaptation of Neurospora crassa Circadian and Conidiation Rhyth ms to Short Light-Dark Cycles." Journal of Fungi 8, no. 1 (2021): 27. http://dx.doi.org/10.3390/jof8010027.

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Circadian clocks control the physiological and behavioral rhythms to adapt to the environment with a period of ~24 h. However, the influences and mechanisms of the extreme light/dark cycles on the circadian clock remain unclear. We showed that, in Neurospora crassa, both the growth and the microconidia production contribute to adaptation in LD12:12 (12 h light/12 h dark, periodically). Mathematical modeling and experiments demonstrate that in short LD cycles, the expression of the core clock protein FREQUENCY was entrained to the LD cycles when LD > 3:3 while it free ran when T ≤ LD3:3. The

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Beesley, Stephen, Dae Wook Kim, Matthew D’Alessandro, et al. "Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis." Proceedings of the National Academy of Sciences 117, no. 45 (2020): 28402–11. http://dx.doi.org/10.1073/pnas.2003524117.

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The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the activator complex in the feedback loop. Although this temporal manifestation of the feedback inhibition is the direct consequence of PER’s cytoplasmic trafficking before nuclear entry, how this spatial regulation of the pacemaker affects circadian timing has been largely unexplored. Here we show tha

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Kato, Shota, and Hong Gil Nam. "The Cell Division Cycle of Euglena gracilis Indicates That the Level of Circadian Plasticity to the External Light Regime Changes in Prolonged-Stationary Cultures." Plants 10, no. 7 (2021): 1475. http://dx.doi.org/10.3390/plants10071475.

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In unicellular photosynthetic organisms, circadian rhythm is tightly linked to gating of cell cycle progression, and is entrained by light signal. As several organisms obtain a fitness advantage when the external light/dark cycle matches their endogenous period, and aging alters circadian rhythms, senescence phenotypes of the microalga Euglena gracilis of different culture ages were characterized with respect to the cell division cycle. We report here the effects of prolonged-stationary-phase conditions on the cell division cycles of E. gracilis under non-24-h light/dark cycles (T-cycles). Und

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Alvarez-Dominguez, Juan R., Julie Donaghey, Niloofar Rasouli, et al. "Organoid Maturation by Circadian Entrainment." StemJournal 2, no. 1 (2020): 7–13. http://dx.doi.org/10.3233/stj-209001.

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Stem cell-derived tissues that recap endogenous physiology are key for regenerative medicine. Yet, most methods yield products that function like fetal, not adult tissues. Organoids are typically grown in constant environments, while our tissues mature along with behavioral cycles. Here, we show that inducing circadian rhythms in pancreatic islet organoids, by entraining them to daily feeding-fasting cycles, elicits their metabolic maturation. Our results show that rhythms can be harnessed to further functional maturation of organoids destined for human therapeutics.

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Potter, Gregory D. M., Janet E. Cade, Peter J. Grant, and Laura J. Hardie. "Nutrition and the circadian system." British Journal of Nutrition 116, no. 3 (2016): 434–42. http://dx.doi.org/10.1017/s0007114516002117.

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AbstractThe human circadian system anticipates and adapts to daily environmental changes to optimise behaviour according to time of day and temporally partitions incompatible physiological processes. At the helm of this system is a master clock in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. The SCN are primarily synchronised to the 24-h day by the light/dark cycle; however, feeding/fasting cycles are the primary time cues for clocks in peripheral tissues. Aligning feeding/fasting cycles with clock-regulated metabolic changes optimises metabolism, and studies of other animals

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Ünsal-Kaçmaz, Keziban, Thomas E. Mullen, William K. Kaufmann, and Aziz Sancar. "Coupling of Human Circadian and Cell Cycles by the Timeless Protein." Molecular and Cellular Biology 25, no. 8 (2005): 3109–16. http://dx.doi.org/10.1128/mcb.25.8.3109-3116.2005.

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ABSTRACT The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate c

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11

Humphries, Jean D. "Workplace Debt: Sleep Loss." Creative Nursing 15, no. 1 (2009): 23–27. http://dx.doi.org/10.1891/1078-4535.15.1.23.

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Normal sleep is characterized by definite cycles of varying sleep depths as well as synchrony with the 24-hour circadian rhythm. Irregular work schedules put nurses at risk for sleep disruption, which is associated with adverse health effects as well as decreased patient safety. Strategies based on maintaining normal sleep cycles and the circadian rhythm can help nurses avoid the adverse effects of sleep loss.

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Tackenberg, Michael C., Jacob J. Hughey, and Douglas G. McMahon. "Distinct Components of Photoperiodic Light Are Differentially Encoded by the Mammalian Circadian Clock." Journal of Biological Rhythms 35, no. 4 (2020): 353–67. http://dx.doi.org/10.1177/0748730420929217.

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Seasonal light cycles influence multiple physiological functions and are mediated through photoperiodic encoding by the circadian system. Despite our knowledge of the strong connection between seasonal light input and downstream circadian changes, less is known about the specific components of seasonal light cycles that are encoded and induce persistent changes in the circadian system. Using combinations of 3 T cycles (23, 24, 26 h) and 2 photoperiods per T cycle (long and short, with duty cycles scaled to each T cycle), we investigate the after-effects of entrainment to these 6 light cycles.

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Brüning, Franziska, Sara B. Noya, Tanja Bange, et al. "Sleep-wake cycles drive daily dynamics of synaptic phosphorylation." Science 366, no. 6462 (2019): eaav3617. http://dx.doi.org/10.1126/science.aav3617.

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The circadian clock drives daily changes of physiology, including sleep-wake cycles, through regulation of transcription, protein abundance, and function. Circadian phosphorylation controls cellular processes in peripheral organs, but little is known about its role in brain function and synaptic activity. We applied advanced quantitative phosphoproteomics to mouse forebrain synaptoneurosomes isolated across 24 hours, accurately quantifying almost 8000 phosphopeptides. Half of the synaptic phosphoproteins, including numerous kinases, had large-amplitude rhythms peaking at rest-activity and acti

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Castillejos-López, Manuel, Yair Romero, Angelica Varela-Ordoñez, et al. "Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases." Cells 12, no. 23 (2023): 2724. http://dx.doi.org/10.3390/cells12232724.

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The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian

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15

Vilaplana, J., T. Cambras, and A. Diez-Noguera. "Dissociation of motor activity circadian rhythm in rats after exposure to LD cycles of 4-h period." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 1 (1997): R95—R102. http://dx.doi.org/10.1152/ajpregu.1997.272.1.r95.

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For > 30 days Wistar rats were subjected to six dark pulses per day (T4 cycles; 3 h light, 1 h dark) to study the possibility of dissociating their motor activity rhythm into distinct circadian components. Rats of both sexes were used, one-half of which were pinealectomized to examine the effect of the pineal gland on the entrainment process. Results show that when rats were maintained under T4 a 4-h rhythm in their motor activity was present. Rats showed anticipatory activity to dark phases, suggesting that the motor activity components are actually entrained to the external light/dark (LD

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16

Lee, Yool, and Jonathan P. Wisor. "Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks." Biology 11, no. 1 (2021): 21. http://dx.doi.org/10.3390/biology11010021.

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The circadian clock is a fundamental biological timing mechanism that generates nearly 24 h rhythms of physiology and behaviors, including sleep/wake cycles, hormone secretion, and metabolism. Evolutionarily, the endogenous clock is thought to confer living organisms, including humans, with survival benefits by adapting internal rhythms to the day and night cycles of the local environment. Mirroring the evolutionary fitness bestowed by the circadian clock, daily mismatches between the internal body clock and environmental cycles, such as irregular work (e.g., night shift work) and life schedul

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De Nobrega, Aliza K., and Lisa C. Lyons. "Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse." Neural Plasticity 2017 (2017): 1–28. http://dx.doi.org/10.1155/2017/4723836.

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Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics. The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse. Invertebrate models, such as

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18

Potter, Gregory D. M., Debra J. Skene, Josephine Arendt, Janet E. Cade, Peter J. Grant, and Laura J. Hardie. "Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures." Endocrine Reviews 37, no. 6 (2016): 584–608. http://dx.doi.org/10.1210/er.2016-1083.

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Abstract Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large propo

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Duez, Hélène, та Bart Staels. "Rev-erb-α: an integrator of circadian rhythms and metabolism". Journal of Applied Physiology 107, № 6 (2009): 1972–80. http://dx.doi.org/10.1152/japplphysiol.00570.2009.

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The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are generated by an internal clock system, which synchronizes these daily variations to the day/night alternance. In addition, circadian oscillations may be reset by the time of food availability in peripheral metabolic organs. Circadian rhythms are seen in many metabolic pathways (glucose and lipid metabolism, etc.) and endocrine secretions (insulin, etc.). As a consequence, misalignment of

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20

Morf, Jörg, and Ueli Schibler. "Body temperature cycles: Gatekeepers of circadian clocks." Cell Cycle 12, no. 4 (2013): 539–40. http://dx.doi.org/10.4161/cc.23670.

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21

Lim, Ga-Young, Tae-Won Jang, Chang-Sun Sim, Yeon Soon Ahn, and Kyoung Sook Jeong. "Comparison of Cortisol level by Shift Cycle in Korean Firefighters." International Journal of Environmental Research and Public Health 17, no. 13 (2020): 4760. http://dx.doi.org/10.3390/ijerph17134760.

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(1) Study Objectives: By investigating the change of cortisol levels during shift cycles among professional firefighters in Korea, this study aims to evaluate the difference between individuals’ stress response and the recovery of their circadian rhythm after working night shifts. (2) Methods: A total of 325 shift firefighters, who were working in 3, 6, 9, or 21 day cycles, participated in the study. Their urinary and serum cortisol levels were measured during the day (09–18), during the night (18–09), and every 24 h (09–09) per shift cycle, and adjustments were made for confounding factors. (

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Wu, Lisa, and Akhilesh B. Reddy. "Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms." Biochemical Society Transactions 42, no. 1 (2014): 1–10. http://dx.doi.org/10.1042/bst20130169.

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Circadian rhythms are a hallmark of living organisms, observable in all walks of life from primitive bacteria to highly complex humans. They are believed to have evolved to co-ordinate the timing of biological and behavioural processes to the changing environmental needs brought on by the progression of day and night through the 24-h cycle. Most of the modern study of circadian rhythms has centred on so-called TTFLs (transcription–translation feedback loops), wherein a core group of ‘clock’ genes, capable of negatively regulating themselves, produce oscillations with a period of approximately

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Granada, Adrián E., Trinitat Cambras, Antoni Díez-Noguera, and Hanspeter Herzel. "Circadian desynchronization." Interface Focus 1, no. 1 (2010): 153–66. http://dx.doi.org/10.1098/rsfs.2010.0002.

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The suprachiasmatic nucleus (SCN) coordinates via multiple outputs physiological and behavioural circadian rhythms. The SCN is composed of a heterogeneous network of coupled oscillators that entrain to the daily light–dark cycles. Outside the physiological entrainment range, rich locomotor patterns of desynchronized rhythms are observed. Previous studies interpreted these results as the output of different SCN neural subpopulations. We find, however, that even a single periodically driven oscillator can induce such complex desynchronized locomotor patterns. Using signal analysis, we show how t

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Park, Chulwook, Jean Hwang, Jae Woong Ahn, and Yu Jin Park. "Perceiving “Complex Autonomous Systems” in Symmetry Dynamics: Elementary Coordination Embedding in Circadian Cycles." International Journal of Environmental Research and Public Health 20, no. 1 (2022): 166. http://dx.doi.org/10.3390/ijerph20010166.

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This study explored the biological autonomy and control of function in circumstances that assessed the presumed relationship of an organism with an environmental cycle. An understanding of this behavior appeals to the organism–environment system rather than just the organism. Therefore, we sought to uncover the laws underlying end-directed capabilities by measuring biological characteristics (motor synchrony) in an environmental cycle (circadian temperature). We found that the typical elementary coordination (bimanual) stability measure varied significantly as a function of the day–night tempe

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Mello, Rebecca M., Marie Pariollaud, and Katja A. Lamia. "Circadian disruption does not alter tumorigenesis in a mouse model of lymphoma." F1000Research 12 (September 28, 2023): 49. http://dx.doi.org/10.12688/f1000research.125272.2.

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Background: Disruption of natural light cycles, as experienced by shift workers, is linked to enhanced cancer incidence. Several mouse models of cancer develop more severe disease when exposed to irregular light/dark cycles, supporting the connection between circadian disruption and increased cancer risk. Cryptochrome 2 (CRY2), a repressive component of the molecular circadian clock, facilitates turnover of the oncoprotein c-MYC, one mechanism that may link the molecular clock to tumorigenesis. In Eμ-MYC mice, which express transgenic c-MYC in B cells and develop aggressive lymphomas and leuke

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Scheer, Frank A. J. L., Michael F. Hilton, Heather L. Evoniuk, et al. "The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles." Proceedings of the National Academy of Sciences 118, no. 37 (2021): e2018486118. http://dx.doi.org/10.1073/pnas.2018486118.

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Asthma often worsens at night. To determine if the endogenous circadian system contributes to the nocturnal worsening of asthma, independent of sleep and other behavioral and environmental day/night cycles, we studied patients with asthma (without steroid use) over 3 wk in an ambulatory setting (with combined circadian, environmental, and behavioral effects) and across the circadian cycle in two complementary laboratory protocols performed in dim light, which separated circadian from environmental and behavioral effects: 1) a 38-h “constant routine,” with continuous wakefulness, constant postu

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Stack, Nora, David Barker, Mary Carskadon, and Cecilia Diniz Behn. "A Model-Based Approach to Optimizing Ultradian Forced Desynchrony Protocols for Human Circadian Research." Journal of Biological Rhythms 32, no. 5 (2017): 485–98. http://dx.doi.org/10.1177/0748730417730488.

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The human circadian system regulates internal 24-h rhythmicity and plays an important role in many aspects of human health and behavior. To investigate properties of the human circadian pacemaker such as intrinsic period and light sensitivity, experimental researchers have developed forced desynchrony (FD) protocols in which manipulations of the light-dark (LD) cycle are used to desynchronize the intrinsic circadian rhythm from the rest-activity cycle. FD protocols have typically been based on exposure to long LD cycles, but recently, ultradian FD protocols with short LD cycles have been propo

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Wyse, C. A., A. N. Coogan, C. Selman, D. G. Hazlerigg, and J. R. Speakman. "Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited." Biology Letters 6, no. 5 (2010): 696–98. http://dx.doi.org/10.1098/rsbl.2010.0152.

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Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by the rotation of the Earth. In the absence of environmental time cues, circadian rhythms default to their endogenous period called tau , or the free-running period. This sustained circadian rhythmicity in constant conditions has been reported across the animal kingdom, a ubiquity that could imply that innate rhythmicity confers an adaptive advantage. In this study, we found that the deviation of tau from 24 h was

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Khatri, Subhash, Rubina Kazi, and Ullas Kolthur-Seetharam. "Shaping mitochondria through fed–fast and circadian cycles." Biochemical Journal 480, no. 13 (2023): 909–19. http://dx.doi.org/10.1042/bcj20220378.

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Energy and metabolic homeostasis at the level of the whole body are dictated by the balance between nutrient intake/utilization, bioenergetic potential, and energy expenditure, which are tightly coupled with fed/fast cycles and circadian oscillation. Emerging literature has highlighted the importance of each of these mechanisms that are essential to maintain physiological homeostasis. Lifestyle changes predominantly associated with altered fed–fast and circadian cycles are well established to affect systemic metabolism and energetics, and hence contribute to pathophysiological states. Therefor

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Morris, Christopher J., Taylor E. Purvis, Joseph Mistretta, and Frank A. J. L. Scheer. "Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers." Journal of Clinical Endocrinology & Metabolism 101, no. 3 (2016): 1066–74. http://dx.doi.org/10.1210/jc.2015-3924.

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Abstract Context: Shift work is a risk factor for diabetes. The separate effects of the endogenous circadian system and circadian misalignment (ie, misalignment between the central circadian pacemaker and 24-hour environmental/behavioral rhythms such as the light/dark and feeding/fasting cycles) on glucose tolerance in shift workers are unknown. Objective: The objective of the study was to test the hypothesis that the endogenous circadian system and circadian misalignment separately affect glucose tolerance in shift workers, both independently from behavioral cycle effects. Design: A randomize

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Kinoshita, Chisato, Yayoi Okamoto, Koji Aoyama, and Toshio Nakaki. "MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases." Clocks & Sleep 2, no. 3 (2020): 282–307. http://dx.doi.org/10.3390/clockssleep2030022.

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Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many o

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de Montaigu, Amaury, Antonis Giakountis, Matthew Rubin, et al. "Natural diversity in daily rhythms of gene expression contributes to phenotypic variation." Proceedings of the National Academy of Sciences 112, no. 3 (2014): 905–10. http://dx.doi.org/10.1073/pnas.1422242112.

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Daily rhythms of gene expression provide a benefit to most organisms by ensuring that biological processes are activated at the optimal time of day. Although temporal patterns of expression control plant traits of agricultural importance, how natural genetic variation modifies these patterns during the day and how precisely these patterns influence phenotypes is poorly understood. The circadian clock regulates the timing of gene expression, and natural variation in circadian rhythms has been described, but circadian rhythms are measured in artificial continuous conditions that do not reflect t

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Wexler, D. B., and M. C. Moore-Ede. "Circadian sleep-wake cycle organization in squirrel monkeys." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 248, no. 3 (1985): R353—R362. http://dx.doi.org/10.1152/ajpregu.1985.248.3.r353.

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To investigate the relationship between circadian rhythms of body temperature and sleep-wake stages, four squirrel monkeys were prepared for unrestrained monitoring of temperature, locomotor activity, electroencephalogram, electroculogram, and electromyogram. Continuous records for each animal were made for several 12-h light-dark (LD) cycles and then after a few days in constant illumination (LL). All animals maintained consolidated sleep-wake cycles and had a longer circadian period (mean 24.7 h) in LL than in LD (mean 24.1 h). The increased period reflected greater time per circadian cycle

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GD, Salmun. "Shift Work and Clinical Applications of Time-Restricted Eating." Food Science & Nutrition Technology 5, no. 2 (2022): 1–6. http://dx.doi.org/10.23880/fsnt-16000214.

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Circadian rhythms refer to the oscillations of biological systems in synchrony with the 24-hour light/dark (LD) cycles of the earth. Mammalian circadian rhythms are coordinated by an array of endogenous “clocks” entrained by environmental inputs (zeitgebers), such as sunlight, locomotion, and food intake. Physiological states including energy balance, sleep-wake cycles, body temperature, and hormonal homeostasis, are all tightly regulated by endogenous circadian clocks. The primary controller of circadian rhythms is located centrally in the Suprachiasmatic Nuclei (SCN) of the hypothalamus, whi

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Hardin, P. E. "Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators." Molecular and Cellular Biology 14, no. 11 (1994): 7211–18. http://dx.doi.org/10.1128/mcb.14.11.7211-7218.1994.

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The period (per) gene is thought to be part of the Drosophila circadian pacemaker. The circadian fluctuations in per RNA and protein that constitute the per feedback loop appear to be required for pacemaker function, and have been measured in head neuronal tissues that are necessary for locomotor activity and eclosion rhythms. The per gene is also expressed in a number of neuronal and nonneuronal body tissues for which no known circadian phenomena have been described. To determine whether per might affect some circadian function in these body tissues, per RNA cycling was examined. These studie

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Walbeek, Thijs J., Elizabeth M. Harrison, Robert R. Soler, and Michael R. Gorman. "Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules." Clocks & Sleep 1, no. 3 (2019): 394–413. http://dx.doi.org/10.3390/clockssleep1030032.

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The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess

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Hardin, P. E. "Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators." Molecular and Cellular Biology 14, no. 11 (1994): 7211–18. http://dx.doi.org/10.1128/mcb.14.11.7211.

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The period (per) gene is thought to be part of the Drosophila circadian pacemaker. The circadian fluctuations in per RNA and protein that constitute the per feedback loop appear to be required for pacemaker function, and have been measured in head neuronal tissues that are necessary for locomotor activity and eclosion rhythms. The per gene is also expressed in a number of neuronal and nonneuronal body tissues for which no known circadian phenomena have been described. To determine whether per might affect some circadian function in these body tissues, per RNA cycling was examined. These studie

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Herzog, Erik D., and Rachel M. Huckfeldt. "Circadian Entrainment to Temperature, But Not Light, in the Isolated Suprachiasmatic Nucleus." Journal of Neurophysiology 90, no. 2 (2003): 763–70. http://dx.doi.org/10.1152/jn.00129.2003.

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The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian rhythms in mammalian physiology and behavior. The abilities to synchronize to daily cycles in the environment and to keep accurate time over a range of physiologic temperatures are two fundamental properties of circadian pacemakers. Recordings from a bioluminescent reporter ( Per1-luc) of Period1 gene activity in rats showed that the cultured SCN entrained to daily, 1.5°C cycles of temperature, but did not synchronize to daily light cycles. Temperature entrainment developed by 1 day after birth. Light cycles failed

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Stahl, Stephen M. "Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients." CNS Spectrums 19, no. 6 (2014): 475–78. http://dx.doi.org/10.1017/s1092852914000637.

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ISSUE:Many individuals with total blindness can develop a circadian rhythm disorder—called non-24 sleep wake syndrome—because they cannot detect light to resynchronize their sleep–wake cycles. A new melatonin 1 and melatonin 2 agonist tasimelteon improves sleep in these patients, resetting their circadian sleep–wake clocks.

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Bromundt, Vivien, Matthias Köster, Angela Georgiev-Kill, et al. "Sleep–wake cycles and cognitive functioning in schizophrenia." British Journal of Psychiatry 198, no. 4 (2011): 269–76. http://dx.doi.org/10.1192/bjp.bp.110.078022.

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BackgroundIrregular sleep–wake cycles and cognitive impairment are frequently observed in schizophrenia, however, how they interact remains unclear.AimsTo investigate the repercussions of circadian rhythm characteristics on cognitive performance and psychopathology in individuals with schizophrenia.MethodFourteen middle-aged individuals diagnosed with schizophrenia underwent continuous wrist actimetry monitoring in real-life settings for 3 weeks, and collected saliva samples to determine the onset of endogenous melatonin secretion as a circadian phase marker. Moreover, participants underwent m

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Isorna, Esther, Nuria de Pedro, Ana I. Valenciano, Ángel L. Alonso-Gómez, and María J. Delgado. "Interplay between the endocrine and circadian systems in fishes." Journal of Endocrinology 232, no. 3 (2017): R141—R159. http://dx.doi.org/10.1530/joe-16-0330.

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The circadian system is responsible for the temporal organisation of physiological functions which, in part, involves daily cycles of hormonal activity. In this review, we analyse the interplay between the circadian and endocrine systems in fishes. We first describe the current model of fish circadian system organisation and the basis of the molecular clockwork that enables different tissues to act as internal pacemakers. This system consists of a net of central and peripherally located oscillators and can be synchronised by the light–darkness and feeding–fasting cycles. We then focus on two c

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Morris, Christopher J., Taylor E. Purvis, Kun Hu, and Frank A. J. L. Scheer. "Circadian misalignment increases cardiovascular disease risk factors in humans." Proceedings of the National Academy of Sciences 113, no. 10 (2016): E1402—E1411. http://dx.doi.org/10.1073/pnas.1516953113.

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Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in humans. Here we show—by using two 8-d laboratory protocols—that short-term circadian misalignment (12-h inverted behavioral and environmental cycles for three da

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Mello, Rebecca M., Marie Pariollaud, and Katja A. Lamia. "Circadian disruption does not alter tumorigenesis in a mouse model of lymphoma." F1000Research 12 (January 12, 2023): 49. http://dx.doi.org/10.12688/f1000research.125272.1.

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Background: Disruption of natural diurnal light cycles, such as that experienced by shift workers, is linked to enhanced cancer incidence. Several mouse models of cancer have been shown to develop more severe disease when exposed to irregular light/dark cycles, further supporting the connection between circadian disruption and increased cancer risk. Cryptochrome 2 (CRY2), a repressive component of the molecular circadian clock, facilitates the turnover of the oncoprotein c-MYC, one mechanism that may link the molecular clock to tumorigenesis. In Eμ-MYC mice, which express transgenic c-MYC in B

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McGuire, J., K. Belani, D. I. Sessler, and K. A. Lee. "Enflurane Anesthesia and Circadian Temperature Cycles in Humans." Anesthesiology 77, Supplement (1992): A193. http://dx.doi.org/10.1097/00000542-199209001-00193.

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Sessler, Daniel I., Kathryn A. Lee, and Joseph McGuire. "Isoflurane Anesthesia and Circadian Temperature Cycles in Humans." Anesthesiology 75, no. 6 (1991): 985–89. http://dx.doi.org/10.1097/00000542-199112000-00010.

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PERAZZO, R. P. J., and A. SCHUSCHNY. "AN ADAPTIVE BOOLEAN AUTOMATON TO MODEL CIRCADIAN CYCLES." International Journal of Neural Systems 07, no. 01 (1996): 83–99. http://dx.doi.org/10.1142/s0129065796000087.

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We propose a Boolean cellular automaton to model an artificial adaptive living organism in order to investigate the development of cyclic vital functions during a simulated evolutionary process. The organism is endowed with a basic architecture consisting of several sensor (input), motor (output) and processing Boolean gates whose connectivity pattern is adapted with a genetic algorithm. Cyclic searching behaviors develop that are tuned to the spatial distribution of “food”. Under additional assumptions we also find that internal pacemakers can develop to adapt plastically to the alternance of

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TOMIOKA, Kenji, and Taishi YOSHII. "Entrainment of Drosophila circadian rhythms by temperature cycles." Sleep and Biological Rhythms 4, no. 3 (2006): 240–47. http://dx.doi.org/10.1111/j.1479-8425.2006.00227.x.

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FRISCH, BRIGITTE, and JÜRGEN ASCHOFF. "Circadian rhythms in honeybees: entrainment by feeding cycles." Physiological Entomology 12, no. 1 (1987): 41–49. http://dx.doi.org/10.1111/j.1365-3032.1987.tb00722.x.

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Merrow, Martha, and Till Roenneberg. "Cellular Clocks: Coupled Circadian and Cell Division Cycles." Current Biology 14, no. 1 (2004): R25—R26. http://dx.doi.org/10.1016/j.cub.2003.12.018.

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Marsili-Libelli, S. "Fuzzy pattern recognition of circadian cycles in ecosystems." Ecological Modelling 174, no. 1-2 (2004): 67–84. http://dx.doi.org/10.1016/j.ecolmodel.2003.12.043.

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