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Journal articles on the topic 'Circadian rhythm disruption'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Angqin, Talin. "Circadian rhythms and depression: A review of mechanisms, effects and treatment strategies." Theoretical and Natural Science 77, no. 1 (2025): 175–82. https://doi.org/10.54254/2753-8818/2024.la19859.

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Circadian rhythms play an important role in the temporal co-ordination of many physiological processes such as the sleep-wake cycle, hormone release or metabolism. Major depressive disorder is associated with severe disruption of these rhythms. This review discusses the basic functions of circadian rhythms and how they control various physiological systems and maintain homeostasis in the body. It also explores epidemiological data linking circadian rhythm disruptions such as insomnia, jet lag, and shift work to a high risk of depression. The review also notes that circadian rhythm disruption c

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Farr, Lynne, Catherine Todero, and Lonna Boen. "Reducing Disruption of Circadian Temperature Rhythm Following Surgery." Biological Research For Nursing 2, no. 4 (2001): 257–66. http://dx.doi.org/10.1177/109980040100200405.

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Temperature and other circadian rhythms are disrupted following surgery and other traumatic events. During recovery, coordination between temperature rhythms and other rhythmic physiologic processes is reduced. Studies of animals and humans have shown that return of synchrony is not immediate, but that it is important in the recovery process. The purpose of this study was to test a combination of cues that have been shown to adjust the timing of circadian temperature rhythm. The combined cues consisted of timed ingestion of caffeine and protein foods and adjustment of the sleep/wake cycle. The

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Tompkins, Olga S. "Circadian Rhythm Disruption." AAOHN Journal 59, no. 2 (2011): 92. http://dx.doi.org/10.3928/08910162-20110126-04.

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Olga, S. Tompkins. "Circadian Rhythm Disruption." AAOHN Journal 59, no. 2 (2011): 92. http://dx.doi.org/10.1177/216507991105900206.

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Safdar, Maryam, and Robert J. Wessells. "Octopamine Rescues Endurance and Climbing Speed in Drosophila Clkout Mutants with Circadian Rhythm Disruption." Cells 12, no. 21 (2023): 2515. http://dx.doi.org/10.3390/cells12212515.

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Circadian rhythm disturbances are associated with various negative health outcomes, including an increasing incidence of chronic diseases with high societal costs. While exercise can protect against the negative effects of rhythm disruption, it is not available to all those impacted by sleep disruptions, in part because sleep disruption itself reduces exercise capacity. Thus, there is a need for therapeutics that bring the benefits of exercise to this population. Here, we investigate the relationship between exercise and circadian disturbances using a well-established Drosophila model of circa

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Li, Jiachun. "Circadian Rhythm and Blood Pressure: research of the latest circadian rhythm in the treatment of hypertension." Theoretical and Natural Science 74, no. 1 (2024): 35–40. https://doi.org/10.54254/2753-8818/2024.la18906.

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The goal of this review was to synthesize present knowledge on the effect of circadian rhythms on blood pressure (BP), circadian misalignment mechanisms that contribute to hypertension, circadian rhythm, and hypertension relationship, the latest research of circadian rhythm diet and pharmacological intervention and assess the possibility of chronotherapy in treatment. BP by modulating biological function is determined by the circadian rhythm process mainly under endogenous control, including the central clock in the suprachiasmatic nucleus (SCN) and peripheral clock. Hypertension has been asso

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Huang, Jiayi. "The Role of Circadian Rhythm Disruption in Prostate Cancer Development: Epidemiological, Molecular, and Therapeutic Perspectives." Theoretical and Natural Science 71, no. 1 (2024): 21–25. https://doi.org/10.54254/2753-8818/2024.la18237.

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Circadian rhythm disruption has been increasingly recognized as a critical factor in the development and development of prostate cancer. Through a comprehensive examination of epidemiological evidence, molecular pathways, and experimental studies, circadian misalignment is shown to influence key biological processes that regulate hormone production, DNA repair, and immune function, all essential to maintaining cellular homeostasis. Disruptions in circadian rhythms can lead to altered gene expression, impacting pathways associated with tumour development. Epidemiological data reveal an elevated

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Cao, Wenxi. "The influence of Circadian Rhythm on Mood Disorders." Theoretical and Natural Science 110, no. 1 (2025): 90–98. https://doi.org/10.54254/2753-8818/2025.au22988.

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Mood disorders are among the leading causes of disability; their etiology is recognized to involve chronobiological dysregulation. The circadian system, governed by a central pacemaker in the suprachiasmatic nucleus (SCN), orchestrates daily rhythms in sleep, hormone secretion, and neurotransmission. Circadian rhythm disruption plays a central role in the onset and maintenance of mood disorders, including major depressive disorder (MDD), bipolar disorder (BD), seasonal affective disorder (SAD), and anxiety. Disruption of these rhythms through environmental factors such as light exposure or gen

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Freund, Nadja, and Ida Haussleiter. "Bipolar Chronobiology in Men and Mice: A Narrative Review." Brain Sciences 13, no. 5 (2023): 738. http://dx.doi.org/10.3390/brainsci13050738.

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In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the “internal clock”, and their disruptions are briefly described. In addition, influences on circadian rhythms such as sleep, genetics, and environment are discussed. This description is conducted with a translational focus covering human patients as well as animal models. Concluding the current knowledge on chronobiology and bipolar disorder, implications for specificity and the course of bipolar disorder and treatment options

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Peng, Xuemin, Rongping Fan, Lei Xie, et al. "A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease." International Journal of Molecular Sciences 23, no. 1 (2022): 504. http://dx.doi.org/10.3390/ijms23010504.

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Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer’s disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms in many diseases. Circadian rhythm disruption is considered to contribute to both T2DM and AD. Here, we review the relationship among circadian rhythm disruption, T2DM and AD, and suggest that the occurrence and progression of T2DM and AD may in part be associated with circadian disruption. Then, we summarize the promising therapeutic strategies targeting circadian dysfunction for T2DM and AD, including pharmacological

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Haruka, Natsume. "The research progress for the treatment of circadian rhythm disorder." Highlights in Science, Engineering and Technology 54 (July 4, 2023): 455–60. http://dx.doi.org/10.54097/hset.v54i.9810.

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With the development of The Times, more and more people need to work at night, which is different from the normal biological clock of life, the body’s internal time and external environmental cues, resulting in the disturbance of circadian rhythm. Circadian rhythm disruptions are common to many people, and people can suffer from problems like chronic sleep deprivation or insomnia. Not only that, but over time it can lead to a variety of diseases that affect their lives and a greatly reduced sense of happiness. Recent research progress has suggested that patients with other medical conditions c

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Saksham Sharma, Manasvi Gupta, Pubali Biswas, Mithra Srinivasan, and Arnav Varghese. "Unraveling the interplay between chronobiology, circadian rhythm, and gut microbiome dynamics in human health." InterConf, no. 43(193) (March 20, 2024): 291–303. http://dx.doi.org/10.51582/interconf.19-20.03.2024.030.

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Background: This study investigates the intricate interplay between disrupted circadian rhythms, sleep variations, and gut microbiota dynamics, recognizing their bidirectional influences on human health. The relationships are explored through the brain-gut-microbiota axis, emphasizing the importance of maintaining a harmonious balance for overall well-being. Methods: A selection criteria was determined after a thorough literature review across search engines and databases. SANRA guidelines were followed to draft the manuscript. Objectives: To elicit the interplay between sleep patterns, chrono

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Ahmad, Mahadir, Nur Syafiqa Balqis Md. Din, Ruthra Devi Tharumalay, et al. "The Effects of Circadian Rhythm Disruption on Mental Health and Physiological Responses among Shift Workers and General Population." International Journal of Environmental Research and Public Health 17, no. 19 (2020): 7156. http://dx.doi.org/10.3390/ijerph17197156.

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Background: The effect of circadian disruption on the bio-psychological clock system has been widely studied. However, the mechanism and the association of circadian rhythm disruption with mental health and physiological responses are still unclear. Therefore, this study was conducted to investigate the effects of circadian rhythm disruption on mental health and physiological responses among shift workers and the general population. Methods: A total of 42 subjects participated in this quasi-experimental study. Participants were divided into a group of shift workers (n = 20) and a general popul

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Lassi, Maximilian, Archana Tomar, Gemma Comas-Armangué, et al. "Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors." Science Advances 7, no. 22 (2021): eabg6424. http://dx.doi.org/10.1126/sciadv.abg6424.

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Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feed

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Samanta, Saptadip, and Debasis Bagchi. "An intricate relationship between circadian rhythm dysfunction and psychiatric diseases." Exploration of Neuroscience 3, no. 4 (2024): 321–51. http://dx.doi.org/10.37349/en.2024.00053.

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There is a complex relationship between circadian rhythm dysfunctions and various psychiatric disorders. Circadian (~24 h) rhythms indicate the rhythmic change of different physiological activities in relation to the environmental light-dark cycle. Shift work, light exposure at night, and chronic and acute jet lag affect circadian rhythm that have a negative impact on psychological functions, and behaviors. Additionally, professional stress, mental instability, and social disintegration influence psychiatric disorders. PubMed/MEDLINE, Springer Nature, Science Direct (Elsevier), Wiley Online, R

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Kiranmai, M. Sai, and M. Raajitha. "A COMPREHENSIVE REVIEW ON CHRONOTHERAPEUTICS." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 82–108. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.007.

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Chronotherapy refers to the use of circadian, ultradian, infradian & seasonal, or other rhythmic cycles in the application of therapy. There are a number of conditions that show a circadian pattern and advantages could be taken by timing and adjusting the administration of drugs according to the circadian rhythm of the disease. Chronotherapy can be divided into three categories: time-controlled systems, in which the drug release is primarily controlled by the delivery system; stimuli-induced PDDS, in which release is controlled by the stimuli, such as the pH or intestinal enzymes; or exter

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Sharma, Arpita, Shashank Tiwari, and Muniyandi Singaravel. "Circadian rhythm disruption: health consequences." Biological Rhythm Research 47, no. 2 (2015): 191–213. http://dx.doi.org/10.1080/09291016.2015.1103942.

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Wang, Han. "Association of circadian rhythm disruption with metabolic diseases represented by obesity." E3S Web of Conferences 553 (2024): 05021. http://dx.doi.org/10.1051/e3sconf/202455305021.

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The majority of creatures on Earth possess an intrinsic biological clock which situates in the suprachiasmatic nucleus of the hypothalamus. It produces a circadian rhythm that coincides with the Earth’s 24-hour cycle through a feedback loop that involves both transcription and translation, which means in regulating metabolism and energy homeostasis of various peripheral organs, such as liver, it plays an vital part. As a result, it has an intricate association in maintaining metabolic health. Outer environmental factors like lifestyle changes may cause Circadian rhythm disorders, and causing h

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Savvidis, Christos, Efthymia Kallistrou, Eleni Kouroglou, et al. "Circadian rhythm disruption and endocrine-related tumors." World Journal of Clinical Oncology 15, no. 7 (2024): 818–34. http://dx.doi.org/10.5306/wjco.v15.i7.818.

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This review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle, energy metabolism, immune function, and cell proliferation. The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue clocks are influenced by cues such as feeding times. Circadian disruption, linked to modern lifestyle factors like

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Delorme, Tara C., Lalit K. Srivastava, and Nicolas Cermakian. "Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?" Journal of Biological Rhythms 35, no. 4 (2020): 325–39. http://dx.doi.org/10.1177/0748730420929448.

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Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent and ubiquitous feature of many psychiatric disorders, including schizophrenia. There is growing interest in uncovering the mechanistic link between schizophrenia and circadian rhythms, which may directly affect disorder outcomes. In this review, we explore the interaction between schizophrenia and circadian rhythms from 2 complementary angles. First, we review evidence that sleep and circadian rhythm disturbances

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Slyepchenko, Anastasiya, Olivia R. Allega, Xiamin Leng, et al. "Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder." Australian & New Zealand Journal of Psychiatry 53, no. 7 (2019): 683–96. http://dx.doi.org/10.1177/0004867419829228.

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Objective: Disruptions in biological rhythms and sleep are a core aspect of mood disorders, with sleep and rhythm changes frequently occurring prior to and during mood episodes. Wrist-worn actigraphs are increasingly utilized to measure ambulatory activity rhythm and sleep patterns. Methods: A comprehensive study using subjective and objective measures of sleep and biological rhythms was conducted in 111 participants (40 healthy volunteers [HC], 38 with major depressive disorder [MDD] and 33 with bipolar disorder [BD]). Participants completed 15-day actigraphy and first-morning urine samples t

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Satyanarayanan, Senthil Kumaran, Huanxing Su, Yi-Wen Lin, and Kuan-Pin Su. "Circadian Rhythm and Melatonin in the Treatment of Depression." Current Pharmaceutical Design 24, no. 22 (2018): 2549–55. http://dx.doi.org/10.2174/1381612824666180803112304.

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Background: Circadian rhythm disruption underlies the pathophysiology of psychiatric disorders, especially depression. Both pharmacological and non-pharmacological strategies affecting endogenous circadian rhythms have been developed with specificity to alter the circadian dysfunction. The current management strategy with antidepressants is far from being satisfactory in addressing this issue. In recent years, attempts at discovering new antidepressants focused on a melatonergic system which is known to be altered in depression have led to a potential option for treatment of depression. Method

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Sun, Ying, Chi-Tang Ho, Yanan Liu, et al. "The Modulatory Effect of Cyclocarya paliurus Flavonoids on Intestinal Microbiota and Hypothalamus Clock Genes in a Circadian Rhythm Disorder Mouse Model." Nutrients 14, no. 11 (2022): 2308. http://dx.doi.org/10.3390/nu14112308.

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Circadian rhythm disruption is detrimental and results in adverse health consequences. We used a multi-omics profiling approach to investigate the effects of Cyclocarya paliurus flavonoid (CPF)-enriched diets on gut microbiota, metabolites, and hypothalamus clock genes in mice with induced circadian rhythm disruption. It was observed that CPF supplementation altered the specific composition and function of gut microbiota and metabolites induced by circadian rhythm disruption. Analysis showed that the abundance of Akkermansia increased, while the abundance of Clostridiales and Ruminiclostridium

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Li, Runze. "The Impact of Circadian Rhythm Disruption on Breast Cancer: Mechanistic Insights into Hormonal Dysregulation, Gene Expression Alterations, and Potential Therapeutic Strategies." Theoretical and Natural Science 75, no. 1 (2025): 83–89. https://doi.org/10.54254/2753-8818/2024.la19355.

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Disruption of the circadian rhythm, frequently due to shift work and nighttime light exposure, is increasingly being associated with a greater risk of breast cancer. This disruption affects melatonin secretion, a hormone known for its tumor-suppressing properties, and alters circadian gene expression, particularly in genes like PER and CRY, which are crucial for regulating the cell cycle and apoptosis. The imbalance in melatonin can lead to increased estrogen activity and promote tumor development. Additionally, circadian misalignment affects metabolic processes, contributing to an environment

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Wulff, Katharina, Derk-Jan Dijk, Benita Middleton, Russell G. Foster, and Eileen M. Joyce. "Sleep and circadian rhythm disruption in schizophrenia." British Journal of Psychiatry 200, no. 4 (2012): 308–16. http://dx.doi.org/10.1192/bjp.bp.111.096321.

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BackgroundSleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions.AimsA systematic exploration of circadian time patterns in individuals with schizophrenia with recurrent sleep disruption.MethodWe examined the relationship between sleep–wake activity, recorded actigraphically over 6 weeks, along with ambient light exposure and simultaneous circadian clock timing, by collecting weekly 48 h profiles of a urinary metabolite of melatonin in 20 out-patients w

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Eckel-Mahan, Kristin, and Paolo Sassone-Corsi. "Metabolism and the Circadian Clock Converge." Physiological Reviews 93, no. 1 (2013): 107–35. http://dx.doi.org/10.1152/physrev.00016.2012.

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Circadian rhythms occur in almost all species and control vital aspects of our physiology, from sleeping and waking to neurotransmitter secretion and cellular metabolism. Epidemiological studies from recent decades have supported a unique role for circadian rhythm in metabolism. As evidenced by individuals working night or rotating shifts, but also by rodent models of circadian arrhythmia, disruption of the circadian cycle is strongly associated with metabolic imbalance. Some genetically engineered mouse models of circadian rhythmicity are obese and show hallmark signs of the metabolic syndrom

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Cappannini, G., S. Bianchi, G. Menculini, et al. "Circadian rhythm disturbances in mood disorders: characterisation and clinical impact." European Psychiatry 66, S1 (2023): S197. http://dx.doi.org/10.1192/j.eurpsy.2023.464.

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IntroductionCircadian rhythms, defined as endogenous oscillations that regulate metabolism, physiology and behaviour, may be frequently disrupted in mood disorders, influencing their clinical presentation and course (Srinivasan V. et al. World J Biol Psychiatry. 2006;7(3):138-151).ObjectivesTo characterise circadian rhythm disruptions in a population of patients with mood disorders, analysing clinical and course differences in subjects with and without clinically significant circadian rhythm alterationsMethodsPatients selected for this cross-sectional study were assessed with CGI-BP, HAM-D, MR

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Consens, Flavia B. "Circadian Rhythm Sleep-Wake Disorders." CONTINUUM: Lifelong Learning in Neurology 29, no. 4 (2023): 1149–66. http://dx.doi.org/10.1212/con.0000000000001287.

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ABSTRACT OBJECTIVE This article provides an overview of advances in the understanding of circadian rhythms and the health implications of circadian disruption. LATEST DEVELOPMENTS Circadian medicine is a relatively new concept, with widespread overlap with many other areas of medicine. Circadian clocks rely on feedback loops that control the expression of many genes. Functional circadian oscillators exist at multiple physiologic levels and facilitate a multimodal clock mechanism. The suprachiasmatic nucleus is the central circadian pacemaker. Peripheral tissues can be entrained by other stimul

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Areshidze, D. A., and L. V. Kakturskiy. "Circadian Rhythms of the Liver and Their Sexual Dimorphism: Current State of the Problem." Innovative Medicine of Kuban, no. 2 (April 29, 2024): 108–14. http://dx.doi.org/10.35401/2541-9897-2024-9-2-108-114.

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The rhythmicity of life functioning processes at the cellular, organ, and system levels is one of the fundamental properties of living things. Among the wide range of biorhythms, circadian rhythms are the most important for mammals. In mammals, circadian rhythms coordinate a wide range of physiological processes with constantly changing environmental conditions, primarily with light conditions. Data on the characteristics of the circadian rhythms of the liver (the most important organ for maintaining homeostasis) are limited and sometimes even contradictory. We aim to analyze modern literature

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Ogunlusi, Olajumoke, Mrinmoy Sarkar, Tristan Nguyen, et al. "Abstract PO3-25-02: Circadian Rhythm Disruption Accelerates Aggressive Mammary Tumorigenesis by Altering Tumor Microenvironment." Cancer Research 84, no. 9_Supplement (2024): PO3–25–02—PO3–25–02. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-25-02.

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Abstract \Breast cancer is the most common cancer in women worldwide, leading to over 650,000 deaths worldwide. The circadian rhythm is a 24-hour biological rhythm that controls most cellular, hormonal, and behavioral processes in living organisms, which is why perturbation of these rhythms is linked to several devastating diseases such as cardiovascular diseases, diabetes, and cancer. In the mammary gland, circadian clocks regulate the rhythmic expression of numerous genes. Circadian rhythm disruption (CRD), which has been termed a "carcinogen" by the International Agency for Research in Canc

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Kubištová, Aneta, Veronika Spišská, Lucie Petrželková, et al. "Constant Light in Critical Postnatal Days Affects Circadian Rhythms in Locomotion and Gene Expression in the Suprachiasmatic Nucleus, Retina, and Pineal Gland Later in Life." Biomedicines 8, no. 12 (2020): 579. http://dx.doi.org/10.3390/biomedicines8120579.

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The circadian clock regulates bodily rhythms by time cues that result from the integration of genetically encoded endogenous rhythms with external cycles, most potently with the light/dark cycle. Chronic exposure to constant light in adulthood disrupts circadian system function and can induce behavioral and physiological arrhythmicity with potential clinical consequences. Since the developing nervous system is particularly vulnerable to experiences during the critical period, we hypothesized that early-life circadian disruption would negatively impact the development of the circadian clock and

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Rifka Wangiana Yulia Putri. "Circadian Rhythm Effect in Depression Management: A Psychosocial Approach." Archives of The Medicine and Case Reports 4, no. 3 (2023): 373–76. http://dx.doi.org/10.37275/amcr.v4i3.319.

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Depression is a kind of mental disorder. It is a risk factor for many diseases. Recently, it has been suggested to contribute to the high mortality rate, especially for young-middle ages. The incidence of depression is studied to be associated with sleep-style change that leads to internal circadian rhythm disruption. The circadian rhythm is related to the light-dark cycle of the sun. Dusk and dawn twilight are an important part of internal circadian rhythm synchronization. These moments correlate with the praying time of Muslims. A socio-spiritual approach could be a potential treatment for d

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Kim, Daham, and Young Suk Jo. "Circadian Rhythm Disruption and Metabolic Syndrome." Journal of Korean Diabetes 15, no. 4 (2014): 216. http://dx.doi.org/10.4093/jkd.2014.15.4.216.

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Savvidis, Christos, and Michael Koutsilieris. "Circadian Rhythm Disruption in Cancer Biology." Molecular Medicine 18, no. 9 (2012): 1249–60. http://dx.doi.org/10.2119/molmed.2012.00077.

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Papagiannakopoulos, Thales, Matthew R. Bauer, Shawn M. Davidson, et al. "Circadian Rhythm Disruption Promotes Lung Tumorigenesis." Cell Metabolism 24, no. 2 (2016): 324–31. http://dx.doi.org/10.1016/j.cmet.2016.07.001.

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Sati, Leyla. "Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome." Reproduction 160, no. 5 (2020): R79—R94. http://dx.doi.org/10.1530/rep-20-0298.

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The circadian system regulates the daily temporal organization in behavior and physiology, including neuroendocrine rhythms and reproduction. Modern life, however, increasingly impacts this complex biological system. Due to limitations of working with human subjects exposed to shift work schedules, most chronoregulation research has used rodent models. Recent publications in these model systems have emphasized the negative effects of circadian rhythm disruption on both female and male reproductive systems and fertility. Additionally, there is growing concern about the long-term effects of circ

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Fatima, Ghizal, Ashish Jha, and Mohsin Ali Khan. "Disruption in Circadian Rhythm Increases Cardiovascular Disease Risk Factors in Shift Working Nurses." Indian Journal of Cardiovascular Disease in Women - WINCARS 06, no. 02 (2021): 079–85. http://dx.doi.org/10.1055/s-0041-1732508.

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Abstract Background Shift work is associated with behavioral, psychosocial, and physiological consequences in the body that may cause cardiovascular disease (CVD) risk. Therefore, in this study we tried to demonstrate the disruption in circadian rhythm of blood pressure by ambulatory blood pressure monitor in shift working nurses. Methods A total of 50 nurses, 25 night shift working nurses (NSWN), and 25 day shift working nurses (DSWN) underwent ambulatory blood pressure monitoring (ABPM) for a period of 24 hours. Along with measurements of inflammatory markers (hs-CRP and IL-6) the risk facto

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Fan, Mingyuet. "The Influence of Circadian Rhythm on Depression." Theoretical and Natural Science 110, no. 1 (2025): 1–6. https://doi.org/10.54254/2753-8818/2025.au22991.

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Depression is a common mental disorder with key symptoms such as low mood, anhedonia, cognitive impairment, and sleep disturbances. The rising prevalence of depression underscores the need to investigate its relationship with circadian rhythm, which could enhance current treatment approaches, such as light therapy and melatonin supplementation. Many individuals with depression experience insomnia, delayed sleep phase, and fragmented sleep, which is related to circadian dysfunction. Circadian rhythm is typically controlled by the suprachiasmatic nucleus and other external clues, such as light o

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Bykov, Yu V. "Review article circadian disruption in pathophysiology of diabetes mellitus." Fundamental and Clinical Medicine 8, no. 3 (2023): 124–30. http://dx.doi.org/10.23946/2500-0764-2023-8-3-124-130.

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Diabetes mellitus is a leading endocrine disease with a steadily increasing incidence, and its complications impose a heavy burden on the healthcare. Although pathophysiology of diabetes mellitus has been extensively investigated through the recent decades, the role of circadian rhythms in this regard was vaguely described. Circadian rhythms comprise an autonomous system of neuroendocrine signals and transcription factors that enfold key physiological processes into a daily cycle. Circadian clocks are subdivided into central (located in the suprachiasmatic nuclei of the hypothalamus) and perip

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Du, Bingcheng. "The Influence of Circadian Rhythm on Cardiovascular Diseases." Theoretical and Natural Science 110, no. 1 (2025): 192–98. https://doi.org/10.54254/2753-8818/2025.au23365.

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Cardiovascular and cerebrovascular diseases are common acute clinical conditions characterized by sudden onset, rapid progression, high rates of disability and mortality, and poor prognosis, often posing life-threatening risks. Ischemic heart disease and stroke rank as the first and second leading causes of death worldwide, respectively. The circadian rhythm, governed by a hierarchical system of central and peripheral oscillators, regulates biological activities in a time-dependent manner. The dominant central pacemaker, located in the suprachiasmatic nucleus of the hypothalamus, synchronizes

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Kinoshita, Chisato, Yayoi Okamoto, Koji Aoyama, and Toshio Nakaki. "MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases." Clocks & Sleep 2, no. 3 (2020): 282–307. http://dx.doi.org/10.3390/clockssleep2030022.

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Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many o

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Wang, Ziqi. "Circadian rhythm disruption, Shift work and its Metabolic impact." Theoretical and Natural Science 75, no. 1 (2025): 48–54. https://doi.org/10.54254/2753-8818/2024.la19350.

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Shift work has an irreplaceable role in many companies and posts, however the negative health impacts are ineluctable, so it is worthy to clarify the possible influence that can post on the metabolism and therefore causing dangerous disorders. The relationship between the shift work and circadian rhythm including the master clock (SCN) and peripheral clock in the tissue and the external environment is researched, in the meantime the various effects are also mentioned. The main focus was on the metabolism, contending that glucose and lipid metabolism has affected by the changes of the circadian

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Werdann, Michelle, and Yong Zhang. "Circadian rhythm and neurodegenerative disorders." Brain Science Advances 6, no. 2 (2020): 71–80. http://dx.doi.org/10.26599/bsa.2020.9050006.

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The circadian clock controls daily rhythms in animal physiology, metabolism, and behavior, such as the sleep‐wake cycle. Disruption of circadian rhythms has been revealed in many diseases including neurodegenerative disorders. Interestingly, patients with many neurodegenerative diseases often show problems with circadian clocks even years before other symptoms develop. Here we review the recent studies identifying the association between circadian rhythms and several major neurodegenerative disorders. Early intervention of circadian rhythms may benefit the treatment of neurodegeneration.

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Magalhães, Ana, Cátia Barra, Ana Borges, and Lèlita Santos. "Diet Modifications towards Restoration of Insulin Sensitivity and Daily Insulin Fluctuations in Diabetes." Diabetology 3, no. 4 (2022): 606–14. http://dx.doi.org/10.3390/diabetology3040046.

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The circadian rhythm is essential in order to maintain metabolic homeostasis and insulin sensitivity. Disruption of circadian mechanisms is associated with the development of metabolic diseases, such as diabetes. Lifestyle changes such as an equilibrated diet and physical activity are known to improve glycaemic control in diabetic patients. One of the mechanisms possibly involved in such an improvement is the restoration of insulin circadian rhythms. There are several available dietary schemes based on circadian rhythms. Some of them are associated with better regulation of daily insulin fluct

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Shevelev, Oleg A., Marina V. Petrova, Mikhail Yu Yuriev, et al. "Study of Brain Circadian Rhythms in Patients with Chronic Disorders of Consciousness and Healthy Individuals Using Microwave Radiometry." Diagnostics 12, no. 8 (2022): 1777. http://dx.doi.org/10.3390/diagnostics12081777.

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The study of circadian rhythms in the human body using temperature measurements is the most informative way to assess the viability of the body’s rhythm-organizing systems. Pathological processes can affect circadian rhythm dynamics in damaged organs. Severe brain damage that caused the development of disorders of consciousness (DOC) (strokes, traumatic brain injury) disrupts the activity of central oscillators, by directly damaging or destroying the periphery links, and the level of preservation of circadian rhythms and the dynamics of their recovery can be informative diagnostic criteria for

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Du, Yao, Xinyue Chen, Susumu Kajiwara, and Kanami Orihara. "Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation." Nutrients 16, no. 14 (2024): 2263. http://dx.doi.org/10.3390/nu16142263.

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Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammation. However, the relationship between intestinal microbiota metabolites and the circadian rhythm of the intestinal barrier was still unclear. Urolithin A (UA), a kind of intestinal microbial metabolite, was selected in this study. Results showed UA influenced on the expression rhythm of the clock genes BMAL1 and PER2 in intestinal epithelial cells.

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Zhou, Shengxiang. "Impact of Circadian Rhythm Disruption on Breast Cancer: Mechanisms and Therapeutic Approaches." Theoretical and Natural Science 74, no. 1 (2025): 170–76. https://doi.org/10.54254/2753-8818/2024.la19347.

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Circadian rhythm disruption plays a critical role in breast cancer pathogenesis, influencing key biological processes such as cell cycle regulation, DNA repair, and apoptosis. This review investigates the molecular mechanisms linking circadian misalignment, often caused by factors such as shift work and irregular light exposure, with increased cancer risk. Dysregulation of circadian genes, including PER and BMAL1, compromises cellular homeostasis, contributing to tumorigenesis. Through a comprehensive secondary analysis of existing literature and experimental data, this review explores therape

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Xu, Jialu. "The Effects of Circadian Rhythm Disorders on Hormones." Theoretical and Natural Science 110, no. 1 (2025): 70–73. https://doi.org/10.54254/2753-8818/2025.au22984.

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The circadian rhythm is an autoregulatory feedback loop that occurs in the suprachiasmatic nucleus of the hypothalamus. It regulates various metabolic activities in the body, with processes controlled at specific times throughout the 24-hour cycle. This feedback loop involves the binding of genes and proteins, maintaining the body's biological clock. However, in modern times, circadian rhythms can often become misaligned due to factors like work schedules or internal issues. Hormones, which can be lipids or proteins, act on target cells to trigger various activities within the body. The types

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Ahmed, A. Ben Cheikh, U. Ouali, I. Bouslama, Y. Zgueb, and F. Nacef. "Chronotype and biological rhythms in bipolar disorders." European Psychiatry 64, S1 (2021): S622. http://dx.doi.org/10.1192/j.eurpsy.2021.1653.

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IntroductionBiological rhythms play an important role in the etiology of mood disorders. Several lines of evidence established a link between circadian rhythm disruption and mood episodes. Chronotypes are the behavioral manifestations of circadian rhythms and eveningness appears to be more frequent in bipolar disorder (BD). The influence of chronotype on mood symptoms needs yet to be clarified.Objectives-Identifying the predominant chronotype in a Tunisian sample of patients with BD -Assessing the association between chronotype and biological rhythm disruptions in the sampleMethodsFor this stu

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Potter, Gregory D. M., Debra J. Skene, Josephine Arendt, Janet E. Cade, Peter J. Grant, and Laura J. Hardie. "Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures." Endocrine Reviews 37, no. 6 (2016): 584–608. http://dx.doi.org/10.1210/er.2016-1083.

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Abstract Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large propo

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