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Journal articles on the topic 'Circadian rhythms'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

DOYLE, SUSAN E., MICHAEL S. GRACE, WILSON McIVOR, and MICHAEL MENAKER. "Circadian rhythms of dopamine in mouse retina: The role of melatonin." Visual Neuroscience 19, no. 5 (2002): 593–601. http://dx.doi.org/10.1017/s0952523802195058.

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Both dopamine and melatonin are important for the regulation of retinal rhythmicity, and substantial evidence suggests that these two substances are mutually inhibitory factors that act as chemical analogs of day and night. A circadian oscillator in the mammalian retina regulates melatonin synthesis. Here we show a circadian rhythm of retinal dopamine content in the mouse retina, and examine the role of melatonin in its control. Using high-performance liquid chromatography (HPLC), we measured levels of dopamine and its two major metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanil

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Brzezinski, Amnon, Seema Rai, Adyasha Purohit, and Seithikurippu R. Pandi-Perumal. "Melatonin, Clock Genes, and Mammalian Reproduction: What Is the Link?" International Journal of Molecular Sciences 22, no. 24 (2021): 13240. http://dx.doi.org/10.3390/ijms222413240.

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Physiological processes and behaviors in many mammals are rhythmic. Recently there has been increasing interest in the role of circadian rhythmicity in the control of reproductive function. The circadian rhythm of the pineal hormone melatonin plays a role in synchronizing the reproductive responses of animals to environmental light conditions. There is some evidence that melatonin may have a role in the biological regulation of circadian rhythms and reproduction in humans. Moreover, circadian rhythms and clock genes appear to be involved in optimal reproductive performance. These rhythms are c

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Powell, Weston T., Lucille M. Rich, Elizabeth R. Vanderwall, Maria P. White, and Jason S. Debley. "Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children." BMJ Open Respiratory Research 9, no. 1 (2022): e001319. http://dx.doi.org/10.1136/bmjresp-2022-001319.

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IntroductionCellular circadian rhythms regulate immune pathways and inflammatory responses that mediate human disease such as asthma. Circadian rhythms in the lung may also contribute to exacerbations of chronic diseases such as asthma by regulating observed rhythms in mucus production, bronchial reactivity, airway inflammation and airway resistance. Primary human airway epithelial cells (AECs) are commonly used to model human lung diseases, such as asthma, with circadian symptoms, but a method for synchronising circadian rhythms in AECs has not been developed, and the presence of circadian rh

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Gubareva, Yekaterina, Mikhail Maydin, Margarita Tyndyk, Irina Vinogradova, and Andrey Panchenko. "CIRCADIAN RHYTHM OF PROLIFERATION IN INTESTINAL EPITHELIUM AND MAMMARY TUMORS IN HER-2/NEU TRANSGENIC AND FVB/N WILD TYPE MICE; THEIR CORRECTION WITH MELATONIN." Problems in oncology 65, no. 1 (2019): 154–58. http://dx.doi.org/10.37469/0507-3758-2019-65-1-154-158.

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Circadian rhythms and tumor development are interconnected as the factors like light pollution which disrupt circadian rhythms increase the risk of cancer, and oncological diseases are associated with changes in organism’s circadian rhythms. Circadian changes in intestinal epithelium and mammary tumors proliferation and apoptosis in HER-2/neu overexpressing FVB/N mice and assessment of melatonin’s influence on these parameters were studied in this work. It was shown by us that intestinal epithelium in mice exhibits circadian rhythm of proliferation with the peak in the morning and in tumor-bea

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Yamanaka, Yujiro. "Basic concepts and unique features of human circadian rhythms: implications for human health." Nutrition Reviews 78, Supplement_3 (2020): 91–96. http://dx.doi.org/10.1093/nutrit/nuaa072.

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Abstract Most physiological functions and behaviors exhibit a robust approximately 24-hour rhythmicity (circadian rhythm) in the real world. These rhythms persist under constant conditions, but the period is slightly longer than 24 hours, suggesting that circadian rhythms are endogenously driven by an internal, self-sustained oscillator. In mammals, including humans, the central circadian pacemaker is located in the hypothalamic suprachiasmatic nucleus. The primary zeitgeber for this pacemaker is bright sunlight, but nonphotic time cues also affect circadian rhythms. The human circadian system

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Li, Jiachun. "Circadian Rhythm and Blood Pressure: research of the latest circadian rhythm in the treatment of hypertension." Theoretical and Natural Science 74, no. 1 (2024): 35–40. https://doi.org/10.54254/2753-8818/2024.la18906.

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The goal of this review was to synthesize present knowledge on the effect of circadian rhythms on blood pressure (BP), circadian misalignment mechanisms that contribute to hypertension, circadian rhythm, and hypertension relationship, the latest research of circadian rhythm diet and pharmacological intervention and assess the possibility of chronotherapy in treatment. BP by modulating biological function is determined by the circadian rhythm process mainly under endogenous control, including the central clock in the suprachiasmatic nucleus (SCN) and peripheral clock. Hypertension has been asso

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Zamoshchina, T. A., M. V. Meleshko, S. V. Logvinov, A. V. Matveуenko, L. N. Novitskaya та Ye V. Ivanova. "The suprahiazmatic nucleus of the forward hypothalamus destruction and circadian rhythms of moving activity, body temperature and renal excretion of Nа+, Cа2+, K+, Li+ in rats in summer solstice". Bulletin of Siberian Medicine 10, № 5 (2011): 50–55. http://dx.doi.org/10.20538/1682-0363-2011-5-50-55.

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In summer solstice it was established that right or left suprachiazmatic nucleus lesion breaks circadian rhythms of rat's moving activity in «open field» and lithium urine excretion. Damage of the left nuclei in a greater degree affects formation circadian rhythm of sodium renal excretion, destruction of the right nuclei - the calcium rhythm organization. The rhythms of body temperature and potassium urine excretion find weak sensitivity to reenergizing right or left suprachiazmatic nucleus. At destruction right or left suprachiazmatic nucleus are formed rhythm's desynchronization, character a

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Farr, Lynne, Catherine Todero, and Lonna Boen. "Reducing Disruption of Circadian Temperature Rhythm Following Surgery." Biological Research For Nursing 2, no. 4 (2001): 257–66. http://dx.doi.org/10.1177/109980040100200405.

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Temperature and other circadian rhythms are disrupted following surgery and other traumatic events. During recovery, coordination between temperature rhythms and other rhythmic physiologic processes is reduced. Studies of animals and humans have shown that return of synchrony is not immediate, but that it is important in the recovery process. The purpose of this study was to test a combination of cues that have been shown to adjust the timing of circadian temperature rhythm. The combined cues consisted of timed ingestion of caffeine and protein foods and adjustment of the sleep/wake cycle. The

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Areshidze, D. A., and L. V. Kakturskiy. "Circadian Rhythms of the Liver and Their Sexual Dimorphism: Current State of the Problem." Innovative Medicine of Kuban, no. 2 (April 29, 2024): 108–14. http://dx.doi.org/10.35401/2541-9897-2024-9-2-108-114.

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The rhythmicity of life functioning processes at the cellular, organ, and system levels is one of the fundamental properties of living things. Among the wide range of biorhythms, circadian rhythms are the most important for mammals. In mammals, circadian rhythms coordinate a wide range of physiological processes with constantly changing environmental conditions, primarily with light conditions. Data on the characteristics of the circadian rhythms of the liver (the most important organ for maintaining homeostasis) are limited and sometimes even contradictory. We aim to analyze modern literature

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Xiao, Yangbo, Ye Yuan, Mariana Jimenez, Neeraj Soni, and Swathi Yadlapalli. "Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms." Proceedings of the National Academy of Sciences 118, no. 28 (2021): e2019756118. http://dx.doi.org/10.1073/pnas.2019756118.

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Circadian clocks regulate ∼24-h oscillations in gene expression, behavior, and physiology. While the genetic and molecular mechanisms of circadian rhythms are well characterized, what remains poorly understood are the intracellular dynamics of circadian clock components and how they affect circadian rhythms. Here, we elucidate how spatiotemporal organization and dynamics of core clock proteins and genes affect circadian rhythms in Drosophila clock neurons. Using high-resolution imaging and DNA-fluorescence in situ hybridization techniques, we demonstrate that Drosophila clock proteins (PERIOD

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Refinetti, Roberto. "Circadian rhythmicity of body temperature and metabolism." Temperature: Multidisciplinary Biomedical Journal 7, no. 4 (2020): 321–62. https://doi.org/10.5281/zenodo.13537197.

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(Uploaded by Plazi for the Bat Literature Project) This article reviews the literature on the circadian rhythms of body temperature and whole-organism metabolism. The two rhythms are first described separately, each description preceded by a review of research methods. Both rhythms are generated endogenously but can be affected by exogenous factors. The relationship between the two rhythms is discussed next. In endothermic animals, modulation of metabolic activity can affect body temperature, but the rhythm of body temperature is not a mere side effect of the rhythm of metabolic thermogenesis

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Refinetti, Roberto. "Circadian rhythmicity of body temperature and metabolism." Temperature: Multidisciplinary Biomedical Journal 7, no. 4 (2020): 321–62. https://doi.org/10.5281/zenodo.13537197.

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(Uploaded by Plazi for the Bat Literature Project) This article reviews the literature on the circadian rhythms of body temperature and whole-organism metabolism. The two rhythms are first described separately, each description preceded by a review of research methods. Both rhythms are generated endogenously but can be affected by exogenous factors. The relationship between the two rhythms is discussed next. In endothermic animals, modulation of metabolic activity can affect body temperature, but the rhythm of body temperature is not a mere side effect of the rhythm of metabolic thermogenesis

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Depres-Brummer, P., F. Levi, G. Metzger, and Y. Touitou. "Light-induced suppression of the rat circadian system." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 5 (1995): R1111—R1116. http://dx.doi.org/10.1152/ajpregu.1995.268.5.r1111.

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In a constant environment, circadian rhythms persist with slightly altered period lengths. Results of studies with continuous light exposure are less clear, because of short exposure durations and single-variable monitoring. This study sought to characterize properties of the oscillator(s) controlling the rat's circadian system by monitoring both body temperature and locomotor activity. We observed that prolonged exposure of male Sprague-Dawley rats to continuous light (LL) systematically induced complete suppression of body temperature and locomotor activity circadian rhythms and their replac

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Mao, Wei, Xingnan Ge, Qianping Chen, and Jia-Da Li. "Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals." Biology 14, no. 1 (2025): 42. https://doi.org/10.3390/biology14010042.

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Almost all organisms, from the simplest bacteria to advanced mammals, havea near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors. Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. These studies have enh

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Luo, Wenxin, Zhangzheng Yin, Mingliang Zhang, Xingguo Huang, and Jie Yin. "Dietary Lactobacillus delbrueckii Affects Ileal Bacterial Composition and Circadian Rhythms in Pigs." Animals 14, no. 3 (2024): 412. http://dx.doi.org/10.3390/ani14030412.

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Intestinal bacteria, synchronized with diet and feeding time, exhibit circadian rhythms and anticipate host gut function; however the effect of dietary probiotics on gut bacterial diurnal rhythms remains obscure. In this study, bacteria were sequenced at 6 Zeitgeber times (ZT) from a pig model of ileal T-shaped fistula to test ileal bacterial composition and circadian rhythms after Lactobacillus delbrueckii administration. The results showed that dietary L. delbrueckii enhanced ileal bacterial α-diversity at Zeitgeber time (ZT) 16, evidenced by an increased Simpson index compared with control

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Angqin, Talin. "Circadian rhythms and depression: A review of mechanisms, effects and treatment strategies." Theoretical and Natural Science 77, no. 1 (2025): 175–82. https://doi.org/10.54254/2753-8818/2024.la19859.

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Circadian rhythms play an important role in the temporal co-ordination of many physiological processes such as the sleep-wake cycle, hormone release or metabolism. Major depressive disorder is associated with severe disruption of these rhythms. This review discusses the basic functions of circadian rhythms and how they control various physiological systems and maintain homeostasis in the body. It also explores epidemiological data linking circadian rhythm disruptions such as insomnia, jet lag, and shift work to a high risk of depression. The review also notes that circadian rhythm disruption c

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Delorme, Tara C., Lalit K. Srivastava, and Nicolas Cermakian. "Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?" Journal of Biological Rhythms 35, no. 4 (2020): 325–39. http://dx.doi.org/10.1177/0748730420929448.

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Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent and ubiquitous feature of many psychiatric disorders, including schizophrenia. There is growing interest in uncovering the mechanistic link between schizophrenia and circadian rhythms, which may directly affect disorder outcomes. In this review, we explore the interaction between schizophrenia and circadian rhythms from 2 complementary angles. First, we review evidence that sleep and circadian rhythm disturbances

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Giannetto, C., F. Fazio, A. Assenza, G. Caola, P. Pennisi, and G. Piccione. "Circadian rhythms of redox states and total locomotor activity in dairy cattle." Czech Journal of Animal Science 55, No. 5 (2010): 183–89. http://dx.doi.org/10.17221/306/2009-cjas.

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We want to study the circadian rhythm of dROMs and anti-oxidative power in dairy cattle during dry period and the possible involvement of the circadian organization of rest/activity cycles in the fluctuation of redox state. For this purpose we recorded TLA in five clinically healthy Bruna Italian dairy cattle by means of an actigraphy-based data logger, Actiwatch-Mini<sup>&reg;</sup>. Blood samples were collected every 3 hours over a 48-hour period for the assessment of free radicals (dROMs) and the antioxidant power: antioxidant barrier (Oxy-ads) and thiol-antioxidant barrier

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Man, Andy W. C., Huige Li, and Ning Xia. "Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis." International Journal of Molecular Sciences 22, no. 2 (2021): 676. http://dx.doi.org/10.3390/ijms22020676.

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Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadia

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Foster, Takesha R., Kwesi A. Dadzie, Olivia Adams, and Melanie R. Gubbels-Bupp. "The Effect of Malnutrition on T-cell Circadian Rhythms." Journal of Immunology 208, no. 1_Supplement (2022): 167.07. http://dx.doi.org/10.4049/jimmunol.208.supp.167.07.

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Abstract In mammals, T-cell migration is under circadian control, likely to anticipate daily rhythms in infection risk. Glucocorticoids are a major controller of circadian processes and malnutrition is associated with increased glucocorticoid secretion. Previous studies suggest malnutrition may impart a “super-quiescent” phenotype to T-cells, enabling a greater number of naïve T-cells to survive short-term malnutrition albeit with diminished function. Thus, we hypothesize that malnourished T-cells may conserve energy by disengaging from rhythmic migration under circadian control and/or foregoi

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Zhang, Shizhong. "Circadian Rhythms and Depression: Exploring the Connection." Theoretical and Natural Science 75, no. 1 (2025): 76–82. https://doi.org/10.54254/2753-8818/2024.la19354.

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Circadian rhythms, which regulate sleep-wake cycles, mood, and various physiological processes, are tightly linked to mental health. Disruptions in circadian rhythms are commonly observed in individuals with depression, manifesting as insomnia, early awakening, or excessive sleepiness. These disturbances can exacerbate depressive symptoms by affecting neurobiological mechanisms, including hormone regulation and neurotransmitter balance. Research indicates that insomnia is not only a consequence of depression but also a potential precursor, highlighting the bidirectional relationship between ci

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Zhang, Xiaozhao, and Ying Jie. "Importance of Circadian Rhythms in the Ocular Surface." Biomolecules 14, no. 7 (2024): 796. http://dx.doi.org/10.3390/biom14070796.

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Circadian rhythms are a ubiquitous feature throughout the organism. Accumulating evidence suggests that the dysfunction of circadian rhythms due to genetic mutations or environmental factors contributes to the genesis and progress of multiple diseases. The physiological homeostasis of the ocular surface, like any other tissue or organ, is also orchestrated by circadian rhythms. In this review, we summarize the molecular clocks and the expression of clock-controlled genes in the mammalian ocular surface. Based on the circadian expression of these genes, we conclude the diurnal oscillations of c

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Kiranmai, M. Sai, and M. Raajitha. "A COMPREHENSIVE REVIEW ON CHRONOTHERAPEUTICS." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 82–108. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.007.

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Chronotherapy refers to the use of circadian, ultradian, infradian & seasonal, or other rhythmic cycles in the application of therapy. There are a number of conditions that show a circadian pattern and advantages could be taken by timing and adjusting the administration of drugs according to the circadian rhythm of the disease. Chronotherapy can be divided into three categories: time-controlled systems, in which the drug release is primarily controlled by the delivery system; stimuli-induced PDDS, in which release is controlled by the stimuli, such as the pH or intestinal enzymes; or exter

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Zhang, Rongyu. "Therapeutic Interventions Targeting Circadian Rhythms." Theoretical and Natural Science 89, no. 1 (2025): 7–13. https://doi.org/10.54254/2753-8818/2025.20310.

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Occurring biologically in a 24-hour cycle, circadian rhythms affect important activities like metabolism, hormone production, and sleep-wake cycles. Many medical illnesses, including sleep problems, depression, and metabolic syndromes, have been linked to disruptions in circadian rhythms. This study reviews the therapeutic approaches that aim to realign disrupted circadian rhythms. Among the methods under discussion are light therapy, melatonin supplements, chronotherapy, and pharmaceutical treatments aiming at circadian paths. The review includes studies that assess the efficacy and utilizati

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Inouye, S. T., J. S. Takahashi, F. Wollnik, and F. W. Turek. "Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 255, no. 6 (1988): R1055—R1058. http://dx.doi.org/10.1152/ajpregu.1988.255.6.r1055.

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The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved in the generation of circadian rhythms in mammals, a protein synthesis inhibitor, anisomycin, was mic

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Deprés-Brummer, Petra, Philippe Bourin, Nicole Pages, Gérard Metzger, and Francis Lévi. "Persistent T lymphocyte rhythms despite suppressed circadian clock outputs in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 6 (1997): R1891—R1899. http://dx.doi.org/10.1152/ajpregu.1997.273.6.r1891.

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Circadian rhythms in circulating leukocyte and lymphocyte counts persisted with halved amplitudes in constant light (LL) of 300 lx intensity for 8 wk, whereas circadian rhythms in body temperature, locomotor activity, and plasma catecholamines were completely suppressed. Subsequent exposure to constant darkness (DD) normalized all circadian rhythms within 2 wk. Rhythms in circulating T lymphocyte subsets were studied in LL or DD using double labeling with monoclonal antibodies and flow cytometry. Circadian rhythms were suppressed for leukocytes and lymphocytes but were maintained for both T he

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Mauvieux, Benoît, Laurent Gouthière, Bruno Sesboüe, and Damien Davenne. "Etudes comparées des rythmes circadiens et reflet actimétrique du sommeil de sportifs et de sédentaires en poste régulier de nuit." Canadian Journal of Applied Physiology 28, no. 6 (2003): 831–87. http://dx.doi.org/10.1139/h03-062.

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The aim of this study was to show the resistance and persistence of the circadian rhythm of temperature (T°) and the sleep quality of athletic subjects and sedentary subjects engaged in night work, and attempt to explain the mechanisms that influence these differences. The effects of night work on biological rhythms have been studied extensively in the past few years. The contradictory situations for the night workers irrefutably affect their biological systems. Individuals with high amplitudes in their circadian rhythms have been found to be more tolerant to shift work and this results in a g

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Kubištová, Aneta, Veronika Spišská, Lucie Petrželková, et al. "Constant Light in Critical Postnatal Days Affects Circadian Rhythms in Locomotion and Gene Expression in the Suprachiasmatic Nucleus, Retina, and Pineal Gland Later in Life." Biomedicines 8, no. 12 (2020): 579. http://dx.doi.org/10.3390/biomedicines8120579.

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The circadian clock regulates bodily rhythms by time cues that result from the integration of genetically encoded endogenous rhythms with external cycles, most potently with the light/dark cycle. Chronic exposure to constant light in adulthood disrupts circadian system function and can induce behavioral and physiological arrhythmicity with potential clinical consequences. Since the developing nervous system is particularly vulnerable to experiences during the critical period, we hypothesized that early-life circadian disruption would negatively impact the development of the circadian clock and

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Bebas, Piotr, Bronislaw Cymborowski, and Jadwiga M. Giebultowicz. "Circadian rhythm of acidification in insect vas deferens regulated by rhythmic expression of vacuolar H+-ATPase." Journal of Experimental Biology 205, no. 1 (2002): 37–44. http://dx.doi.org/10.1242/jeb.205.1.37.

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SUMMARY Recent studies have demonstrated that the peripheral tissues of vertebrates and invertebrates contain circadian clocks; however, little is known about their functions and the rhythmic outputs that they generate. To understand clock-controlled rhythms at the cellular level, we investigated a circadian clock located in the reproductive system of a male moth (the cotton leaf worm Spodoptera littoralis) that is essential for the production of fertile spermatozoa. Previous work has demonstrated that spermatozoa are released from the testes in a daily rhythm and are periodically stored in th

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Meléndez-Fernández, O. Hecmarie, Jennifer A. Liu, and Randy J. Nelson. "Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism." International Journal of Molecular Sciences 24, no. 4 (2023): 3392. http://dx.doi.org/10.3390/ijms24043392.

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Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce and production, and expanding social life around the clock. However, physiology and behavior that evolved in the context of 24 h solar days are frequently perturbed by exposure to artificial light at night. This is particularly salient in the context of circadian rhythms, the result of endogenous biological clocks with a rhythm of ~24 h. Circadian rhythms govern the temporal features of physiology and behavior, and are set to precisely 24 h primarily by exposure t

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Shevelev, Oleg A., Marina V. Petrova, Mikhail Yu Yuriev, et al. "Study of Brain Circadian Rhythms in Patients with Chronic Disorders of Consciousness and Healthy Individuals Using Microwave Radiometry." Diagnostics 12, no. 8 (2022): 1777. http://dx.doi.org/10.3390/diagnostics12081777.

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The study of circadian rhythms in the human body using temperature measurements is the most informative way to assess the viability of the body’s rhythm-organizing systems. Pathological processes can affect circadian rhythm dynamics in damaged organs. Severe brain damage that caused the development of disorders of consciousness (DOC) (strokes, traumatic brain injury) disrupts the activity of central oscillators, by directly damaging or destroying the periphery links, and the level of preservation of circadian rhythms and the dynamics of their recovery can be informative diagnostic criteria for

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Nadiminti, Venkata Murali, Sriteja Ganta, Sudheendra Babu Mathangi, Sunita Kanikaram, and Bhanu Prasad Gadde. "Role of Circadian Disruptions and Epigenetic Modifications in Cancer and Neuro Developmental Disorders." Research Journal of Biotechnology 8, no. 20 (2025): 289. https://doi.org/10.25303/208rjbt2890297.

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Circadian rhythms are physiological processes which regulate the sleep-wake cycle, metabolism and hormonal functions driven by clock genes. Suprachiasmatic nucleus (SCN), located in the anterior hypothalamus, regulates the mammalian circadian clock. Disruptions in circadian rhythms are associated with various metabolic disorders, neurodevelopmental conditions and cancers. Melatonin is crucial for synchronizing circadian rhythms, it maintains physiological homeostasis and particularly stabilizing the circadian clock under conditions of inflammation and stress. Circadian rhythms misalignments su

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Jaeger, Cassie, Ali Q. Khazaal, Canxin Xu, Mingwei Sun, Stacey L. Krager, and Shelley A. Tischkau. "Aryl Hydrocarbon Receptor Deficiency Alters Circadian and Metabolic Rhythmicity." Journal of Biological Rhythms 32, no. 2 (2017): 109–20. http://dx.doi.org/10.1177/0748730417696786.

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PAS domain–containing proteins can act as environmental sensors that capture external stimuli to allow coordination of organismal physiology with the outside world. These proteins permit diverse ligand binding and heterodimeric partnership, allowing for varied combinations of PAS-dependent protein-protein interactions and promoting crosstalk among signaling pathways. Previous studies report crosstalk between circadian clock proteins and the aryl hydrocarbon receptor (AhR). Activated AhR forms a heterodimer with the circadian clock protein Bmal1 and thereby functionally inhibits CLOCK/Bmal1 act

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Yin, Yueci. "Study on the Correlation Between the Genetics of Circadian Rhythms and Neurodegenerative Diseases." BIO Web of Conferences 124 (2024): 02010. http://dx.doi.org/10.1051/bioconf/202412402010.

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In the context of global population aging, the increasing incidence of neurodegenerative diseases presents a serious challenge to healthcare systems worldwide. This article meticulously reviews the genetic links between circadian rhythms and neurodegenerative diseases, revealing their complex interactions and potential implications for disease management and prevention. The foundational mechanisms of circadian rhythms, the roles of related genes, and the genetic basis of neurodegenerative diseases are explored. The relationship between circadian rhythm gene variations and neurodegenerative dis

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Rajan, Pradeep Kumar, Utibe-Abasi S. Udoh, Robert Finley, Sandrine V. Pierre, and Juan Sanabria. "The Biological Clock of Liver Metabolism in Metabolic Dysfunction-Associated Steatohepatitis Progression to Hepatocellular Carcinoma." Biomedicines 12, no. 9 (2024): 1961. http://dx.doi.org/10.3390/biomedicines12091961.

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Circadian rhythms are endogenous behavioral or physiological cycles that are driven by a daily biological clock that persists in the absence of geophysical or environmental temporal cues. Circadian rhythm-related genes code for clock proteins that rise and fall in rhythmic patterns driving biochemical signals of biological processes from metabolism to physiology and behavior. Clock proteins have a pivotal role in liver metabolism and homeostasis, and their disturbances are implicated in various liver disease processes. Encoded genes play critical roles in the initiation and progression of meta

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von Gall, Charlotte. "The Effects of Light and the Circadian System on Rhythmic Brain Function." International Journal of Molecular Sciences 23, no. 5 (2022): 2778. http://dx.doi.org/10.3390/ijms23052778.

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Life on earth has evolved under the influence of regularly recurring changes in the environment, such as the 24 h light/dark cycle. Consequently, organisms have developed endogenous clocks, generating 24 h (circadian) rhythms that serve to anticipate these rhythmic changes. In addition to these circadian rhythms, which persist in constant conditions and can be entrained to environmental rhythms, light drives rhythmic behavior and brain function, especially in nocturnal laboratory rodents. In recent decades, research has made great advances in the elucidation of the molecular circadian clockwor

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McGoogan, Jennifer M., and Vincent M. Cassone. "Circadian regulation of chick electroretinogram: effects of pinealectomy and exogenous melatonin." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277, no. 5 (1999): R1418—R1427. http://dx.doi.org/10.1152/ajpregu.1999.277.5.r1418.

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Melatonin is an important component of the avian circadian system. This study investigates the effects of pinealectomy (Pin-X) and melatonin implantation (Mel) on electroretinogram (ERG) rhythms in chicks. Feeding rhythms were monitored to obtain a phase reference for ERG recordings. Pin-X and Mel had little or no effect on feeding rhythms. Sham-operated Pin-X and vehicle implantation had no effect on ERG rhythms in the light-dark (LD) cycle or constant darkness (DD). ERG a- and b-wave amplitudes were higher during the day than during the night. The a- and b-wave implicit times were shorter du

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Lee, Eun. "Wearable Technology in Circadian Rhythm Research: From Monitoring to Clinical Insights." Chronobiology in Medicine 7, no. 1 (2025): 3–8. https://doi.org/10.33069/cim.2025.0011.

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This review article explores the role of wearable technology in circadian rhythm research, providing an in-depth examination of its applications, benefits, limitations, and future potential. Wearable devices continuously monitor physiological parameters such as movement, heart rate, skin temperature, and light exposure, allowing researchers to analyze circadian rhythms in real-world settings. By collecting data on circadian phase shifts, amplitude, and stability, these devices offer valuable insights into the relationship between circadian rhythms and health outcomes. The article discusses the

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Menaker, M. "CIRCADIAN RHYTHMS: Circadian Photoreception." Science 299, no. 5604 (2003): 213–14. http://dx.doi.org/10.1126/science.1081112.

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Dearry, A., and R. B. Barlow. "Circadian rhythms in the green sunfish retina." Journal of General Physiology 89, no. 5 (1987): 745–70. http://dx.doi.org/10.1085/jgp.89.5.745.

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We investigated the occurrence of circadian rhythms in retinomotor movements and retinal sensitivity in the green sunfish, Lepomis cyanellus. When green sunfish were kept in constant darkness, cone photoreceptors exhibited circadian retinomotor movements; rod photoreceptors and retinal pigment epithelium (RPE) pigment granules did not. Cones elongated during subjective night and contracted during subjective day. These results corroborate those of Burnside and Ackland (1984. Investigative Ophthalmology and Visual Science. 25:539-545). Electroretinograms (ERGs) recorded in constant darkness in r

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Thurley, Kevin, Christopher Herbst, Felix Wesener, et al. "Principles for circadian orchestration of metabolic pathways." Proceedings of the National Academy of Sciences 114, no. 7 (2017): 1572–77. http://dx.doi.org/10.1073/pnas.1613103114.

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Circadian rhythms govern multiple aspects of animal metabolism. Transcriptome-, proteome- and metabolome-wide measurements have revealed widespread circadian rhythms in metabolism governed by a cellular genetic oscillator, the circadian core clock. However, it remains unclear if and under which conditions transcriptional rhythms cause rhythms in particular metabolites and metabolic fluxes. Here, we analyzed the circadian orchestration of metabolic pathways by direct measurement of enzyme activities, analysis of transcriptome data, and developing a theoretical method called circadian response a

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Arzola-Rodríguez, Jesús José. "Sueño y ritmos circadianos en supervivientes de falla respiratoria aguda." Kompass Neumología 3, no. 1 (2021): 14–15. http://dx.doi.org/10.1159/000513799.

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<b>Background:</b> Little is known about sleep and circadian rhythms in survivors of acute respiratory failure (ARF) after hospital discharge. <b>Objectives:</b> To examine sleep and rest-activity circadian rhythms in ARF survivors 3 months after hospital discharge, and to compare them with a community-dwelling population. <b>Methods:</b> Sleep diary, actigraphy data, and insomnia symptoms were collected in a pilot study of 14 ARF survivors. Rest-activity circadian rhythms were assessed with wrist actigraphy and sleep diary for 9 days, and were analyzed by c

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Luo, Yujie, Xinhang Meng, Liyuan Cui, and Songcun Wang. "Circadian Regulation of Lipid Metabolism during Pregnancy." International Journal of Molecular Sciences 25, no. 21 (2024): 11491. http://dx.doi.org/10.3390/ijms252111491.

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A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia. Growing studies have confirmed that resynchronizing circadian rhythms might alleviate metabolic disturbance. H

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Lv, Lanxing, Xiaoxi Yan, Mingyue Zhou, Huaming He, and Yan Jia. "Circadian Rhythms of Skin Surface Lipids and Physiological Parameters in Healthy Chinese Women Reveals Circadian Changes in Skin Barrier Function." Biology 13, no. 12 (2024): 1031. https://doi.org/10.3390/biology13121031.

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Background: Circadian rhythms are driven by the biological clock, an endogenous oscillator that generates approximately 24 h cycles in mammals. The circadian regulation of the lipid metabolism plays a crucial role in overall metabolic health. An analysis of the correlation between the skin’s physiological parameters and skin lipids can provide a better insight into the rhythmic changes in skin condition. Objectives: The aim was to reveal how skin surface lipids (SSLs) participate in the regulation of circadian rhythms in the skin and the importance of the circadian oscillation of facial lipid

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Foldes, A., J. B. Donnelly, C. A. Maxwell, S. B. James, and S. L. Clancy. "Circadian rhythm in wool depilation force in Merino and Merino X Border Leicester sheep." Journal of Agricultural Science 104, no. 2 (1985): 397–403. http://dx.doi.org/10.1017/s0021859600044087.

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SummaryAs part of an ongoing investigation of ovine neuroendocrine mechanisms relating to photoperiod and eventually to wool growth, the diurnal variation of depilation force (an index of the strength of attachment of wool fibres to the skin of sheep) was investigated in Merino wethers and Border Leicester Merino ewes. Circadian rhythms were demonstrated in depilation force in both ewes and wethers. Further experiments were performed to investigate circadian endocrine rhythms which may have some bearing on the observed rhythm in depilation force. Circadian rhythms 180° out of phase with the de

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Turek, Fred W. "Circadian Rhythms." Hormone Research in Paediatrics 49, no. 3-4 (1998): 109–13. http://dx.doi.org/10.1159/000023155.

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SAMPLES, JULIE F., MARY LOU VAN COTT, CHARLENE LONG, IMOGENE M. KING, and ANGELA KERSENBROCK. "Circadian Rhythms." Nursing Research 34, no. 6 (1985): 377???379. http://dx.doi.org/10.1097/00006199-198511000-00021.

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Hines, P. J. "Circadian Rhythms." Science Signaling 7, no. 319 (2014): ec87-ec87. http://dx.doi.org/10.1126/scisignal.2005313.

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Eichner, E. Randy. "Circadian Rhythms." Physician and Sportsmedicine 22, no. 10 (1994): 82–93. http://dx.doi.org/10.1080/00913847.1994.11710504.

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Lakin-Thomas, Patricia L. "Circadian rhythms." Trends in Genetics 16, no. 3 (2000): 135–42. http://dx.doi.org/10.1016/s0168-9525(99)01945-9.

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