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Journal articles on the topic 'Circovirus infection'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Lőrincz, Márta, Attila Cságola, Szilvia L. Farkas, Csaba Székely, and Tamás Tuboly. "First detection and analysis of a fish circovirus." Journal of General Virology 92, no. 8 (2011): 1817–21. http://dx.doi.org/10.1099/vir.0.031344-0.

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Circoviruses are present worldwide in birds and pigs but their occurrence in fish has not yet been reported. Recently, increased mortality was observed in barbel fry (Barbus barbus) in Hungary. This paper reports the detection of previously unknown circular viral DNA genomes in barbels by the use of a circovirus-specific wide-range nested PCR. The analysis of two complete genomes (Barbel circovirus, BaCV1 and BaCV2) indicated that they belonged into a new genetic group within the family Circoviridae, distinct from known circoviruses and circovirus-like genomes. Their genome size was 1957 bases

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2

POPOVA, V. M., O. A. BOGOMOLOVA, E. V. MARKOVA, Yu N. FEDOROV, and L. S. LYULKOVA. "SWINE CIRCOVIRUS INFECTION (REVIEW)." PIG-BREEDING, no. 3 (2020): 8–10. http://dx.doi.org/10.37925/0039-713x-2020-3-8-10.

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3

Choi, Changsun, Chanhee Chae, and Edward G. Clark. "Porcine Postweaning Multisystemic Wasting Syndrome in Korean Pig: Detection of Porcine Circovirus 2 Infection by Immunohistochemistry and Polymerase Chain Reaction." Journal of Veterinary Diagnostic Investigation 12, no. 2 (2000): 151–53. http://dx.doi.org/10.1177/104063870001200209.

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This report describes the first diagnosis of porcine circovirus (PCV) infection in weaned pigs with postweaning multisystemic wasting syndrome in Korea by immunohistochemistry and polymerase chain reaction. The most unique lesions were multifocal granulomatous inflammation affecting lymph nodes, liver, and spleen, characterized by infiltrates of epithelioid macrophages and multinucleated giant cells. Circoviral antigen was detected in formalin-fixed sections and was usually present in large, round, dendritic cells in the white pulp of spleen and remnants of follicles in lymph nodes. Lymphoid f

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4

WOODS, LESLIE W., and KENNETH S. LATIMER. "Circovirus Infection of Nonpsittacine Birds." Journal of Avian Medicine and Surgery 14, no. 3 (2000): 154–63. http://dx.doi.org/10.1647/1082-6742(2000)014[0154:cionb]2.0.co;2.

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5

TUBOKAWA, Tadashi, and Shuji HONDA. "Circovirus Infection in Underdeveloped Pigs." Journal of the Japan Veterinary Medical Association 53, no. 3 (2000): 144–47. http://dx.doi.org/10.12935/jvma1951.53.144.

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6

TAJIMA, Masanori. "Porcine Circovirus Infection in Pigs." Journal of the Japan Veterinary Medical Association 53, no. 2 (2000): 53–58. http://dx.doi.org/10.12935/jvma1951.53.53.

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7

Cao, Jingjing, Cui Lin, Huijuan Wang, et al. "Circovirus Transport Proceeds via Direct Interaction of the Cytoplasmic Dynein IC1 Subunit with the Viral Capsid Protein." Journal of Virology 89, no. 5 (2014): 2777–91. http://dx.doi.org/10.1128/jvi.03117-14.

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ABSTRACTMicrotubule transport of circovirus from the periphery of the cell to the nucleus is essential for viral replication in early infection. How the microtubule is recruited to the viral cargo remains unclear. In this study, we observed that circovirus trafficking is dependent on microtubule polymerization and that incoming circovirus particles colocalize with cytoplasmic dynein and endosomes. However, circovirus binding to dynein was independent of the presence of microtubular α-tubulin and translocation of cytoplasmic dynein into the nucleus. The circovirus capsid (Cap) subunit enhanced

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8

Ouyang, Ting, Xinwei Zhang, Xiaohua Liu, and Linzhu Ren. "Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses." Viruses 11, no. 2 (2019): 185. http://dx.doi.org/10.3390/v11020185.

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Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication of other pathogens. However, the exact mechanisms of PCVD/PCVAD are currently unknown. To date, many studies have reported that several cofactors, such as other swine viruses or bacteria, vaccination failure, and stress or crowding, in combination with PCV2, lead to PCVD/PCVAD. Am

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9

Alex, Charles E., Elizabeth Fahsbender, Eda Altan, et al. "Viruses in unexplained encephalitis cases in American black bears (Ursus americanus)." PLOS ONE 15, no. 12 (2020): e0244056. http://dx.doi.org/10.1371/journal.pone.0244056.

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Viral infections were investigated in American black bears (Ursus americanus) from Nevada and northern California with and without idiopathic encephalitis. Metagenomics analyses of tissue pools revealed novel viruses in the genera Circoviridae, Parvoviridae, Anelloviridae, Polyomaviridae, and Papillomaviridae. The circovirus and parvovirus were of particular interest due to their potential importance as pathogens. We characterized the genomes of these viruses and subsequently screened bears by PCR to determine their prevalence. The circovirus (Ursus americanus circovirus, UaCV) was detected at

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10

Stafford, V. V. "SECOND TYPE OF PIGS’ CIRCOVIRUS INFECTION." Russian Journal of Agricultural and Socio-Economic Sciences 65, no. 5 (2017): 306–9. http://dx.doi.org/10.18551/rjoas.2017-05.39.

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11

Smyth, J., and B. Carroll. "Circovirus infection in European racing pigeons." Veterinary Record 136, no. 7 (1995): 173–74. http://dx.doi.org/10.1136/vr.136.7.173.

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12

Woods, Leslie W., Kenneth S. Latimer, Bradd C. Barr, et al. "Circovirus-Like Infection in a Pigeon." Journal of Veterinary Diagnostic Investigation 5, no. 4 (1993): 609–12. http://dx.doi.org/10.1177/104063879300500417.

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13

Gjurovski, Ivica, Branko Angelovski, Toni Dovenski, Dine Mitrov, and Trpe Ristoski. "Diagnostic Characteristics of Circovirus Infection in Pigs." Macedonian Veterinary Review 38, no. 1 (2015): 73–78. http://dx.doi.org/10.14432/j.macvetrev.2014.11.033.

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Abstract The aim of this study is to compare the results from the histopathology and the immunohistochemical method in the diagnostic of Porcine circovirus type 2 (PCV2) infection in pigs. The circovirus infection is a pig disease that is caused by a small, spherical, nonenveloped virus with a single stranded DNA genome which is spread throughout the pig industry worldwide. The circovirus is the etiological agent of a several pig diseases which today are thought to be the cause of the greatest economical loses in pig production. The most important of these diseases is the PMWS (post-weaning mu

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14

Woods, Leslie W., Kenneth S. Latimer, Frank D. Niagro, et al. "A Retrospective Study of Circovirus Infection in Pigeons: Nine Cases (1986–1993)." Journal of Veterinary Diagnostic Investigation 6, no. 2 (1994): 156–64. http://dx.doi.org/10.1177/104063879400600205.

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Circovirus infections were diagnosed in 12 pigeons from the United States, 4 pigeons from Australia, and 1 pigeon from Canada (1986-1993). Circovirus was identified by electron microscopic examination of basophilic botryoid cytoplasmic inclusions that had a histologic appearance similar to that of psittacine beak and feather disease virus inclusions. Inclusions were seen in splenic, bursal, gut-associated, and bronchus-associated lymphoid tissue macrophages and in bursal epithelial cells. Inclusions were composed of paracrystalline arrays of tightly packed, nonenveloped icosahedral virions 14-

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15

Ouyang, Ting, Guyu Niu, Yifang Zhang, et al. "Porcine HMGCR Inhibits Porcine Circovirus Type 2 Infection by Directly Interacting with the Viral Proteins." Viruses 11, no. 6 (2019): 544. http://dx.doi.org/10.3390/v11060544.

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Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood. We previously found that 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is negatively associated with PCV2 infection in vitro and in vivo. HMGCR inhibits the early stages of PCV2 infection, while PCV2 infection induces the phosphorylation of HMGCR to inactivate the protein. In this study, we investigated the possibility that adenosine 5′-monophosphate (AMP)-activated protein kinase

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16

Edwards, S., and J. Sands. "Evidence of circovirus infection in British pigs." Veterinary Record 134, no. 26 (1994): 680–81. http://dx.doi.org/10.1136/vr.134.26.680.

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17

Maes, Dominiek. "Subclinical porcine circovirus infection: What lies beneath." Veterinary Journal 194, no. 1 (2012): 9. http://dx.doi.org/10.1016/j.tvjl.2012.06.029.

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18

Ouyang, Ting, Xiao-hui Liu, Hong-sheng Ouyang, and Lin-zhu Ren. "Mouse models of porcine circovirus 2 infection." Animal Models and Experimental Medicine 1, no. 1 (2018): 23–28. http://dx.doi.org/10.1002/ame2.12009.

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19

Soike, Dirk, Kim Hattermann, Kerstin Albrecht, et al. "A diagnostic study on columbid circovirus infection." Avian Pathology 30, no. 6 (2001): 605–11. http://dx.doi.org/10.1080/03079450120092099.

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20

Taner ;OĞUZOĞLU, KARAOĞLU. "Porcine circovirus type 2 infection in Turkey." Ankara Üniversitesi Veteriner Fakültesi Dergisi 58, no. 2 (2011): 93–97. http://dx.doi.org/10.1501/vetfak_0000002456.

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21

Nisavic, Jakov, Andrea Zoric, and Nenad Milic. "The application of molecular methods in the diagnostics of infection of swine caused by Porcine circovirus 2." Veterinarski glasnik 70, no. 5-6 (2016): 249–58. http://dx.doi.org/10.2298/vetgl1606249n.

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Porcine circovirus 2 (PCV2) belongs to the family Circoviridae, genus Circovirus. Infection of swine caused by this virus is manifested in several different clinical forms, leading to significant economic losses in swine production worldwide. For this reason, prompt and precise diagnostics of this swine infection is of great importance. For this purpose today there are used molecular methods of virological diagnostics such as polymerase chain reaction (PCR), and real-time method PCR, that is direct sequencing method by Sanger.

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22

Sidler, Xaver, Titus Sydler, José Maria Mateos, Stefanie Klausmann, and Enrico Brugnera. "Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation." Pathogens 9, no. 10 (2020): 839. http://dx.doi.org/10.3390/pathogens9100839.

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Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general. The virus can be phylogenetically subdivided into PCV2a to PCV2h genotypes. Although vaccination against PCV2 has been seen to prevent the manifestation of PCV disease, PCV2 still lingers as subclinical infections in all developmental stages of pigs. The “slow and low” tactic gives PCV2 a particular advantage in a host’s immune surveillance. Since the inception of the

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23

MATVEEVA, I. N., E. V. MARKOVA, O. A. BOGOMOLOVA, Yu N. FEDOROV, and L. S. LYULKOVA. "IMMUNOCYTOCHEMICAL METHOD FOR DIAGNOSTICS OF PORCINE CIRCOVIRUS INFECTION." PIG-BREEDING, no. 4 (2020): 51–53. http://dx.doi.org/10.37925/0039-713x-2020-4-51-53.

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24

Dvorak, Cheryl M. T., Sumathy Puvanendiran, and Michael P. Murtaugh. "Cellular pathogenesis of porcine circovirus type 2 infection." Virus Research 174, no. 1-2 (2013): 60–68. http://dx.doi.org/10.1016/j.virusres.2013.03.001.

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25

Krakowka, Steven, John A. Ellis, Francis McNeilly, et al. "Immunologic Features of Porcine Circovirus Type 2 Infection." Viral Immunology 15, no. 4 (2002): 567–82. http://dx.doi.org/10.1089/088282402320914511.

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26

Schmidt, Volker, Julian Schlömer, Caroline Lüken, et al. "Experimental Infection of Domestic Pigeons with Pigeon Circovirus." Avian Diseases 52, no. 3 (2008): 380–86. http://dx.doi.org/10.1637/8188-120407-reg.

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27

Schmidt, Volker, Julian Schlömer, Caroline Lüken, et al. "Experimental Infection of Domestic Pigeons with Pigeon Circovirus." Avian Diseases Digest 3, no. 3 (2008): e3-e3. http://dx.doi.org/10.1637/8402.1.

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28

Abadie, Jérôme, Frédérique Nguyen, Caroline Groizeleau, et al. "Pigeon circovirus infection: Pathological observations and suggested pathogenesis." Avian Pathology 30, no. 2 (2001): 149–58. http://dx.doi.org/10.1080/03079450124811.

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29

Shivaprasad, H. L., Daphne Hill, Daniel Todd, and Joan A. Smyth. "Circovirus infection in a Gouldian finch (Chloebia gouldiae)." Avian Pathology 33, no. 5 (2004): 525–29. http://dx.doi.org/10.1080/03079450400003585.

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30

Biryuchenkova, M. V., A. M. Timina, and A. V. Shcherbakov. "DETECTION OF PORCINE CIRCOVIRUS TYPE 3 IN RUSSIAN PIG HOLDINGS." Veterinary Science Today, no. 3 (October 3, 2019): 29–33. http://dx.doi.org/10.29326/2304-196x-2019-3-30-29-33.

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Diseases associated with porcine circoviruses (mainly with porcine circovirus type 2) have various manifestations, are common in pigs in countries having well-developed pig industry and responsible for significant economic losses. Porcine circovirus type 3 (PCV-3) causing systemic inflammation of unknown etiology in animals was detected the USA in 2015. Later, data on PCV-3 detection in Asia, Europe and South America were published. Analysis of literature data on current epidemic situation on PCV-3 infection in foreign countries as well as the disease clinical manifestations and postmortem les

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31

Streltsova, Ya B. "THE MODERN EPIZOOTOLOGY FOR PORCINE CIRCOVIRUS DISEASE." Problems of Veterinary Sanitation, Hygiene and Ecology 1, no. 1 (2018): 129–35. http://dx.doi.org/10.36871/vet.san.hyg.ecol.201801022.

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This article describes the historical-geographical and epizootological aspects of rising porcine circovirus infection, periods of study and spread of infection. The article contains the information about epizootic situation in the World and in Russian Federation. The methods of diagnosis, clinical and pathological manifestation are represented. In modern pig farming are important issues related to the comprehensive diagnosis of diseases of pigs, especially circovirus infection. The disease has various symptoms and mortality among piglets in the early period of rearing. Asymptomatic manifestati

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32

Kennedy, Seamus, Joaquim Segalés, Albert Rovira, et al. "Absence of Evidence of Porcine Circovirus Infection in Piglets with Congenital Tremors." Journal of Veterinary Diagnostic Investigation 15, no. 2 (2003): 151–56. http://dx.doi.org/10.1177/104063870301500209.

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Porcine circovirus types 1 (PCV1) and 2 (PCV2) have been associated with congenital tremors (CTs) in piglets in the United States. In this study, central nervous system and nonneural tissues of 40 CT piglets from Spain, the United Kingdom, Ireland, and Sweden were investigated for the presence of PCV1 and PCV2 using in situ hybridization and immunohistochemical labeling on paraffin sections. The polymerase chain reaction for PCV2 was also carried out on sera from the Spanish CT cases. No evidence of circovirus nucleic acid or antigen was found in any CT piglet. Although these results do not su

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33

Hattermann, Kim, Claudia Roedner, Cornelia Schmitt, Tim Finsterbusch, Tobias Steinfeldt, and Annette Mankertz. "Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2." Xenotransplantation 11, no. 3 (2004): 284–94. http://dx.doi.org/10.1111/j.1399-3089.2004.00134.x.

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34

Dudar, L., V. Polischuk, L. Budzanivska, Gyula Balka, and Attila Csagola. "COMPLETE GENOME SEQUENCE OF PORCINE CIRCOVIRUS TYPE 2 UKRAINIAN ISOLATES." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 72, no. 2 (2016): 5–8. http://dx.doi.org/10.17721/1728_2748.2016.72.5-8.

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Porcine circovirus type 2 (PCV2) is associated with distinct syndromes and diseases in swine, collectively known as porcine circovirus-associated diseases (PCVAD), which include postweaning multisystemic wasting syndrome (PMWS), PCV2-associated pneumonia as a part of the porcine respiratory disease complex (PRDC), PCV2-associated enteritis, PCV2-associated reproductive failure, and porcine dermatitis and nephropathy syndrome (PDNS) (1–3). PCV2-infection is widespread and essentially all pig herds are infected with PCV2. Porcine circovirus 2 (PCV2), a member of the genus Circovirus in the famil

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35

Kekarainen, Tuija, Maria Montoya, Enric Mateu, and Joaquim Segalés. "Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses." Journal of General Virology 89, no. 3 (2008): 760–65. http://dx.doi.org/10.1099/vir.0.83354-0.

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Porcine circovirus type 2 (PCV2) is the necessary agent for the occurrence of post-weaning multisystemic wasting syndrome (PMWS) in pigs. It has been suggested that PMWS-affected pigs are immunosuppressed and, therefore, more prone to develop co-infections. In this study, we elucidated that PCV2 downregulates in vitro the immune cell functions during recall antigen responses. We showed that PCV2, but not the non-pathogenic porcine circovirus type 1, induces interleukin (IL)-10 secretion by monocytic cells. Notably, PCV2-induced IL-10 led to effective repression of IL-12 in blood peripheral mon

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36

Novitska, O. "CLINICAL SIGNS IN DIAGNOSTIC OF CIRCOVIRUS INFECTION IN PIGS." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 18, no. 3(71) (2016): 66–69. http://dx.doi.org/10.15421/nvlvet7115.

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Clinical signs the disease associated with porcine circovirus (PCVAD) imitate many other diseases (classical swine fever, transmissible gastroenteritis, porcine parvovirus, pseudo rabies (Aujeszky’s disease), leptospirosis et al.), which complicates diagnosis of the disease in the early stages of infection among livestock. Late diagnosis, lack of treatment and high price vaccines contribute to the formation of stationary fire PCVD. Therefore, the preliminary diagnosis based on clinical signs and pathological changes in animals suffering from PCV2, is the primary in fight PCVD. According the no

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37

Hattermann, Kim, Dirk Soike, Christian Grund, and Annette Mankertz. "A method to diagnose Pigeon circovirus infection in vivo." Journal of Virological Methods 104, no. 1 (2002): 55–58. http://dx.doi.org/10.1016/s0166-0934(02)00038-1.

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38

Smyth, J. A., D. Todd, A. Scott, et al. "Identification of circovirus infection in three species of gull." Veterinary Record 159, no. 7 (2006): 212–14. http://dx.doi.org/10.1136/vr.159.7.212.

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39

Sun, J., L. Wei, Z. Lu, et al. "Retrospective study of porcine circovirus 3 infection in China." Transboundary and Emerging Diseases 65, no. 3 (2018): 607–13. http://dx.doi.org/10.1111/tbed.12853.

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40

Huang, Yen-Li, Omir Adrian Castaneda, Duangsuda Thongchan, Rupak Khatri-Chhetri, Shinn-Shyong Tsai, and Hung-Yi Wu. "Pigeon circovirus infection in disqualified racing pigeons from Taiwan." Avian Pathology 46, no. 4 (2017): 359–66. http://dx.doi.org/10.1080/03079457.2017.1284305.

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41

Patterson, A. R., S. Ramamoorthy, D. M. Madson, X. J. Meng, P. G. Halbur, and T. Opriessnig. "Shedding and infection dynamics of porcine circovirus type 2 (PCV2) after experimental infection." Veterinary Microbiology 149, no. 1-2 (2011): 91–98. http://dx.doi.org/10.1016/j.vetmic.2010.10.020.

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42

Lőrincz, Márta, Attila Cságola, Imre Biksi, Levente Szeredi, Ádám Dán, and Tamás Tuboly. "Detection of porcine circovirus in rodents — Short communication." Acta Veterinaria Hungarica 58, no. 2 (2010): 265–68. http://dx.doi.org/10.1556/avet.58.2010.2.12.

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Porcine circoviruses (PCV) are present worldwide, infecting domestic pigs and wild boars alike. Studies under laboratory conditions indicated that PCV can be taken up by mice and the virus can replicate in these animals. The possible role of rodents in maintaining and transmitting PCV2 infection in the field has not been investigated yet. The present study reports the detection of PCV2, the pathogenic form of the virus, in mice and rats. A number of rodents, such as mice, rats and voles, were collected at PCV2-infected farms and also outside pig herds and tested for the presence of the virus b

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43

Kotsyumbas, G., and M. Shkil. "Pathomorphological characteristic of immune organs for circovirus infection of piglets." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 83 (2018): 150–55. http://dx.doi.org/10.15421/nvlvet8329.

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The article elucidates the results of pathoanatomical and histological searches of peripheral immune organs for circovirus infection of piglets. In one of the farms of Transcarpathian region among the pigs of 3–4 months of age were found clinically ill animals, blood was taken, serum test was performed and circiiros was diagnosed. The pathoanatomical autopsy of 12 corpses of piglets was done. During the autopsy of corpses macroscopic changes were studied and samples of mesenteric lymph nodes and spleen were taken, which were fixed in 10% neutral formalin, dehydrated in alcohols of increasing c

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44

Mateusen, B., R. E. Sanchez, A. Van Soom, P. Meerts, D. G. D. Maes, and H. J. Nauwynck. "Susceptibility of pig embryos to porcine circovirus type 2 infection." Theriogenology 61, no. 1 (2004): 91–101. http://dx.doi.org/10.1016/s0093-691x(03)00187-0.

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45

Järveots, T., T. Saar, D. Põdersoo, et al. "Lawsonia intracellularis and Porcine Circovirus type-2 infection in Estonia." Polish Journal of Veterinary Sciences 19, no. 2 (2016): 291–301. http://dx.doi.org/10.1515/pjvs-2016-0036.

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AbstractThe present study describes the reasons of post-weaning distress in Estonian pig herds. Here we examined the natural cases ofLawsonia intracellularisand porcine circovirus 2 (PCV2) infection and co-infections.The presence ofL. intracellularisin swine herds were tested by PCR and by histopathological methods, whereas PCV2 was detected by real-time-PCR and immunohistochemical stainings. Seven of the 11 investigated herds with signs of post-weaning wasting were infected withL. intracellularisand all 11 herds with PCV2.From the analysed samples 22.2% were infected withL. intracellularisand

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46

Zhai, Shao-Lun, and Yun Xi. "Can porcine circovirus type 3 cause persistent infection in pigs?" Veterinary Record 184, no. 20 (2019): 617–18. http://dx.doi.org/10.1136/vr.l1940.

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47

McNeilly, F., G. M. Allan, J. C. Foster, B. M. Adair, and M. S. McNulty. "Effect of porcine circovirus infection on porcine alveolar macrophage function." Veterinary Immunology and Immunopathology 49, no. 4 (1996): 295–306. http://dx.doi.org/10.1016/0165-2427(95)05476-6.

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48

Järveots, T., D. Põdersoo, T. Saar, S. Boudinot, and R. Lindjärv. "Porcine Proliferative Enteropathy and Porcine Circovirus 2 Infection in Estonia." Journal of Comparative Pathology 146, no. 1 (2012): 75. http://dx.doi.org/10.1016/j.jcpa.2011.11.120.

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49

Fang, Manxin, Yi Yang, Naidong Wang, et al. "Genome-wide analysis of long non-coding RNA expression profile in porcine circovirus 2-infected intestinal porcine epithelial cell line by RNA sequencing." PeerJ 7 (March 6, 2019): e6577. http://dx.doi.org/10.7717/peerj.6577.

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Porcine circovirus-associated disease (PCVAD), which is induced by porcine circovirus type 2 (PCV2), is responsible for severe economic losses. Recently, the role of noncoding RNAs, and in particular microRNAs, in PCV2 infection has received great attention. However, the role of long noncoding RNA (lncRNA) in PCV2 infection is unclear. Here, for the first time, we describe the expression profiles of lncRNAs in an intestinal porcine epithelial cell line (IPEC-J2) after PCV2 infection, and analyze the features of differently expressed lncRNAs and their potential target genes. After strict filter

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50

Ramamoorthy, Sheela, and Xiang-Jin Meng. "Porcine circoviruses: a minuscule yet mammoth paradox." Animal Health Research Reviews 10, no. 1 (2008): 1–20. http://dx.doi.org/10.1017/s1466252308001461.

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Abstract:

AbstractPorcine circovirus type 2 (PCV2) is the primary causative agent for porcine circovirus-associated disease (PCVAD). PCVAD has been the cause of considerable economic losses to the pork industry worldwide. The disease is primarily characterized by wasting, enlarged lymph nodes, jaundice and weight loss in affected weanling pigs. Several other complex syndromes involving reproductive failure, enteritis, pneumonia and necrotizing dermatitis have also been associated with PCV2 infection. Lymphoid depletion, which is the hallmark lesion of PCVAD, predisposes the host to immunosuppression. Di

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