Academic literature on the topic 'CircRNAs, brain wiring, axon'

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Journal articles on the topic "CircRNAs, brain wiring, axon"

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Lewis, Tommy L., Julien Courchet, and Franck Polleux. "Cellular and molecular mechanisms underlying axon formation, growth, and branching." Journal of Cell Biology 202, no. 6 (2013): 837–48. http://dx.doi.org/10.1083/jcb.201305098.

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Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon specification during neuronal polarization, axon growth, and terminal axon branching during synaptogenesis.
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Mason, Carol, and Nefeli Slavi. "Retinal Ganglion Cell Axon Wiring Establishing the Binocular Circuit." Annual Review of Vision Science 6, no. 1 (2020): 215–36. http://dx.doi.org/10.1146/annurev-vision-091517-034306.

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Binocular vision depends on retinal ganglion cell (RGC) axon projection either to the same side or to the opposite side of the brain. In this article, we review the molecular mechanisms for decussation of RGC axons, with a focus on axon guidance signaling at the optic chiasm and ipsi- and contralateral axon organization in the optic tract prior to and during targeting. The spatial and temporal features of RGC neurogenesis that give rise to ipsilateral and contralateral identity are described. The albino visual system is highlighted as an apt comparative model for understanding RGC decussation,
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Agi, Egemen, Eric T. Reifenstein, Charlotte Wit, et al. "Axonal self-sorting without target guidance in Drosophila visual map formation." Science 383, no. 6687 (2024): 1084–92. http://dx.doi.org/10.1126/science.adk3043.

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The idea of guidance toward a target is central to axon pathfinding and brain wiring in general. In this work, we show how several thousand axonal growth cones self-pattern without target-dependent guidance during neural superposition wiring in Drosophila . Ablation of all target lamina neurons or loss of target adhesion prevents the stabilization but not the development of the pattern. Intravital imaging at the spatiotemporal resolution of growth cone dynamics in intact pupae and data-driven dynamics simulations reveal a mechanism by which >30,000 filopodia do not explore potential targets
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Wang, Wei, Asit Rai, Eun-Mi Hur, Zeev Smilansky, Karen T. Chang, and Kyung-Tai Min. "DSCR1 is required for both axonal growth cone extension and steering." Journal of Cell Biology 213, no. 4 (2016): 451–62. http://dx.doi.org/10.1083/jcb.201510107.

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Local information processing in the growth cone is essential for correct wiring of the nervous system. As an axon navigates through the developing nervous system, the growth cone responds to extrinsic guidance cues by coordinating axon outgrowth with growth cone steering. It has become increasingly clear that axon extension requires proper actin polymerization dynamics, whereas growth cone steering involves local protein synthesis. However, molecular components integrating these two processes have not been identified. Here, we show that Down syndrome critical region 1 protein (DSCR1) controls
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Jia, Erteng, Ying Zhou, Zhiyu Liu, et al. "Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson’s Disease in a Mouse Model." International Journal of Molecular Sciences 21, no. 8 (2020): 3006. http://dx.doi.org/10.3390/ijms21083006.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease and although many studies have been done on this disease, the underlying mechanisms are still poorly understood and further studies are warranted. Therefore, this study identified circRNA expression profiles in the cerebral cortex (CC), hippocampus (HP), striatum (ST), and cerebellum (CB) regions of the 1-methyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model using RNA sequencing (RNA-seq), and differentially expressed circRNA were validated using reverse transcription quantitative real-time PCR (qRT-PCR). Ge
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Umeda, Kentaro, Nariaki Iwasawa, Manabu Negishi, and Izumi Oinuma. "A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner." Molecular Biology of the Cell 26, no. 10 (2015): 1957–70. http://dx.doi.org/10.1091/mbc.e15-01-0039.

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Precise wiring patterns of axons are among the remarkable features of neuronal circuit formation, and establishment of the proper neuronal network requires control of outgrowth, branching, and guidance of axons. R-Ras is a Ras-family small GTPase that has essential roles in multiple phases of axonal development. We recently identified afadin, an F-actin–binding protein, as an effector of R-Ras mediating axon branching through F-actin reorganization. Afadin comprises two isoforms—l-afadin, having the F-actin–binding domain, and s-afadin, lacking the F-actin–binding domain. Compared with l-afadi
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Charron, F. "Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance." Development 132, no. 10 (2005): 2251–62. http://dx.doi.org/10.1242/dev.01830.

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Rhiner, Christa, and Michael O. Hengartner. "Sugar Antennae for Guidance Signals: Syndecans and Glypicans Integrate Directional Cues for Navigating Neurons." Scientific World JOURNAL 6 (2006): 1024–36. http://dx.doi.org/10.1100/tsw.2006.202.

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Attractive and repulsive signals guide migrating nerve cells in all directions when the nervous system starts to form. The neurons extend thin processes, axons, that connect over wide distances with other brain cells to form a complicated neuronal network. One of the most fascinating questions in neuroscience is how the correct wiring of billions of nerve cells in our brain is controlled. Several protein families are known to serve as guidance cues for navigating neurons and axons. Nevertheless, the combinatorial potential of these proteins seems to be insufficient to sculpt the entire neurona
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Moreno Bravo, J. A. "Development of bilateral circuits of the nervous system: From molecular mechanisms to the cerebellum and its implication in neurodevelopmental disorders." ANALES RANM 139, no. 139(03) (2023): 229–35. http://dx.doi.org/10.32440/ar.2022.139.03.rev02.

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The brain is the most complex organ we have, and it is the one that defines us as human beings. It is the basis of intelligence, of our thoughts and memories. In addition, it interprets the world through the senses, initiates movement and controls our behaviors. The correct functioning of this organ is based on the correct establishment of connectivity patterns between the millions of neurons which enable a precise and efficient communication between them. These neural networks emerge during embryonic and postnatal development. The formation of proper neuronal circuitry relies on diverse and v
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Hardin, Katherine R., Arjolyn B. Penas, Shuristeen Joubert, Changtian Ye, Kenneth R. Myers, and James Q. Zheng. "A critical role for the fascin family of actin bundling proteins in axon development, brain wiring and function." Molecular and Cellular Neuroscience 134 (September 2025): 104027. https://doi.org/10.1016/j.mcn.2025.104027.

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Dissertations / Theses on the topic "CircRNAs, brain wiring, axon"

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Masante, Linda. "The missing rings of neurodevelopment: circRNAs in brain wiring." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/338658.

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circRNAs are covalently closed RNA molecules recently re-discovered thanks to the advances in RNA-seq technology. They are produced by the canonical spliceosome in a non-canonical splicing process, named back-splicing. Heterogeneous in internal composition and highly stable, circRNAs regained the attention of neuronal biologists because of their enrichment in brain and neuronal compartments. Moreover, several pioneering studies revealed a fine orchestration of circRNA expression in crucial stages of neuronal development, such as synaptogenesis. The growing evidence of circRNA enrichment in syn
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Ng, David. "Wiring the brain with Neto1: A multivalent NMDA receptor interacting CUB domain protein with essential roles in axon guidance, synaptic plasticity, and hippocampal-dependant spatial learning and memory." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=449915&T=F.

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Books on the topic "CircRNAs, brain wiring, axon"

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Ng, David. Wiring the brain with Neto1: A multivalent NMDA receptor interacting CUB domain protein with essential roles in axon guidance, synaptic plasticity, and hippocampal-dependant spatial learning and memory. 2006.

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Book chapters on the topic "CircRNAs, brain wiring, axon"

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Sanes, Dan H., Thomas A. Reh, William A. Harris, and Matthias Landgraf. "Wiring Up the Brain: Axon Navigation." In Development of the Nervous System. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-803996-0.00005-8.

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