Log in

Relevant bibliographies by topics / CircRNAs / Journal articles

To see the other types of publications on this topic, follow the link: CircRNAs.

Journal articles on the topic 'CircRNAs'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'CircRNAs.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Hossain, Md Tofazzal, Yin Peng, Shengzhong Feng, and Yanjie Wei. "FcircSEC: An R Package for Full Length circRNA Sequence Extraction and Classification." International Journal of Genomics 2020 (June 1, 2020): 1–11. http://dx.doi.org/10.1155/2020/9084901.

Full text

Abstract:

Circular RNAs (circRNAs) are formed by joining the 3′ and 5′ ends of RNA molecules. Identification of circRNAs is an important part of circRNA research. The circRNA prediction methods can predict the circRNAs with start and end positions in the chromosome but cannot identify the full-length circRNA sequences. We present an R package FcircSEC (Full Length circRNA Sequence Extraction and Classification) to extract the full-length circRNA sequences based on gene annotation and the output of any circRNA prediction tools whose output has a chromosome, start and end positions, and a strand for each

APA, Harvard, Vancouver, ISO, and other styles

2

Li, Jing, Heng Yang, Huaran Shi, Jihong Zhang, and Wei Chen. "Expression Profiles of Differentially Expressed Circular RNAs and circRNA–miRNA–mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5." International Journal of Genomics 2022 (October 10, 2022): 1–15. http://dx.doi.org/10.1155/2022/9298149.

Full text

Abstract:

Coxsackievirus B5 (CVB5) is the causative agent of hand, foot, and mouth disease (HFMD) that can cause neurological complications and fatalities. Circular RNA (circRNA) has been shown to play an important role in regulating pathogenic processes. However, the functions of circRNA in response to CVB5 infection remain unclear. In our research, RNA-seq was employed to analyze the expression profiles of circRNAs in SH-SY5Y cells with or without CVB5 infection. Out of 5,665 circRNAs identified to be expressed in SH-SY5Y cells, 163 circRNAs were found to be differentially expressed significantly. Mor

APA, Harvard, Vancouver, ISO, and other styles

3

Gu, Alison, Dabbu Kumar Jaijyan, Shaomin Yang, Mulan Zeng, Shaokai Pei, and Hua Zhu. "Functions of Circular RNA in Human Diseases and Illnesses." Non-Coding RNA 9, no. 4 (2023): 38. http://dx.doi.org/10.3390/ncrna9040038.

Full text

Abstract:

Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free ends. Emerging evidence indicates that circRNAs perform essential functions in many DNA viruses, including coronaviruses, Epstein–Barr viruses, cytomegalovirus, and Kaposi sarcoma viruses. Recent studies have confirmed that circRNAs are present in viruses, including DNA and RNA viruses, and play various important functions such as evading host immune response, disease pathogenesis, protein translation, miRNA sponges, regul

APA, Harvard, Vancouver, ISO, and other styles

4

Cheng, Feiran, Ji Li, Chaoying Hu, et al. "Study on the Characterization and Degradation Pattern of Circular RNA Vaccines Using an HPLC Method." Chemosensors 12, no. 7 (2024): 120. http://dx.doi.org/10.3390/chemosensors12070120.

Full text

Abstract:

Circular RNA (circRNA) vaccines have attracted increasing attention due to their stable closed-loop structures and persistent protein expression ability. During the synthesis process, nicked circRNAs with similar molecular weights to those of circRNAs are generated. Analytical techniques based on differences in molecular weight, such as capillary electrophoresis, struggle to distinguish between circRNAs and nicked circRNAs. The characteristic degradation products of circRNAs and their biological activities remain unclear. Therefore, developing methods to identify target circRNAs and non-target

APA, Harvard, Vancouver, ISO, and other styles

5

Shi, Junhao, Junxia Pu, Lv Zhou, Jie Shan, Yeni Zhang, and Yibin Deng. "The Dysregulated circRNAs in Hepatocellular Carcinoma Were Identified Through Circular RNA Sequencing and Bioinformatics Analysis." International Journal of Biology and Life Sciences 5, no. 2 (2024): 48–52. http://dx.doi.org/10.54097/2g5xv950.

Full text

Abstract:

Background: The research evidence suggests that dysregulated circRNAs are closely associated with the progression of HCC and can serve as diagnostic markers and therapeutic targets for HCC. However, the status of differentially expressed circRNAs in HCC cancerous tissues and adjacent non-cancerous tissues remains unclear. Methods: Firstly, circRNA-Seq was employed to screen for dysregulated circRNAs in HCC tissues and adjacent non-cancerous tissues. Secondly, differential expression of circRNAs in the GSE97332 dataset was identified using bioinformatics methods. Lastly, the intersection of cir

APA, Harvard, Vancouver, ISO, and other styles

6

Sun, Yan, Yonghui Wang, Yuhua Li, Faheem Akhtar, Changfa Wang, and Qin Zhang. "Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys." Genes 14, no. 1 (2022): 66. http://dx.doi.org/10.3390/genes14010066.

Full text

Abstract:

Circular RNAs (circRNAs) are a class of noncoding RNAs with a covalently closed loop. Studies have demonstrated that circRNA can function as microRNA (miRNA) sponges or competing endogenous RNAs. Although circRNA has been explored in some species and tissues, the genetic basis of testis development and spermatogenesis in donkeys remain unknown. We performed RNA-seq to detect circRNA expression profiles of adult donkey testes. Length distribution and other characteristics were shown a total of 1971 circRNAs were differentially expressed and 12,648 and 6261 circRNAs were detected from the testis

APA, Harvard, Vancouver, ISO, and other styles

7

Li, Shasha, Shuaishuai Teng, Junquan Xu, et al. "Microarray is an efficient tool for circRNA profiling." Briefings in Bioinformatics 20, no. 4 (2018): 1420–33. http://dx.doi.org/10.1093/bib/bby006.

Full text

Abstract:

Abstract Circular RNAs (circRNAs) are emerging as a new class of endogenous and regulatory noncoding RNAs in latest years. With the widespread application of RNA sequencing (RNA-seq) technology and bioinformatics prediction, large numbers of circRNAs have been identified. However, at present, we lack a comprehensive characterization of all these circRNAs in interested samples. In this study, we integrated 87 935 circRNAs sequences that cover most of circRNAs identified till now represented in circBase to design microarray probes targeting back-splice site of each circRNA to profile expression

APA, Harvard, Vancouver, ISO, and other styles

8

Liang, Yan, Qisong Gao, Haiyang Wang, et al. "Identification and Characterization of Circular RNAs in Mammary Tissue from Holstein Cows at Early Lactation and Non-Lactation." Biomolecules 12, no. 3 (2022): 478. http://dx.doi.org/10.3390/biom12030478.

Full text

Abstract:

In this study, circular RNAs (circRNAs) from Holstein cow mammary tissues were identified and compared between early lactation and non-lactation. After analysis, 10,684 circRNAs were identified, ranging from 48 to 99,406 bp, and the average size was 882 bp. The circRNAs were mainly distributed on chromosomes 1 to 11, and 89.89% of the circRNAs belonged to sense-overlapping circRNA. The exons contained with circRNAs ranged from 1 to 47 and were concentrated from 1 to 5. Compared with the non-lactating cows, 87 circRNAs were significantly differentially expressed in the peak lactation cows. Ther

APA, Harvard, Vancouver, ISO, and other styles

9

López-Nieva, Pilar, Pablo Fernández-Navarro, María Ángeles Cobos-Fernández, et al. "Patterns of Differentially Expressed circRNAs in Human Thymocytes." Non-Coding RNA 8, no. 2 (2022): 26. http://dx.doi.org/10.3390/ncrna8020026.

Full text

Abstract:

Circular RNAs (circRNAs) are suggested to play a discriminative role between some stages of thymocyte differentiation. However, differential aspects of the stage of mature single-positive thymocytes remain to be explored. The purpose of this study is to investigate the differential expression pattern of circRNAs in three different development stages of human thymocytes, including mature single-positive cells, and perform predictions in silico regarding the ability of specific circRNAs when controlling the expression of genes involved in thymocyte differentiation. We isolate human thymocytes at

APA, Harvard, Vancouver, ISO, and other styles

10

Xuan, Rong, Jianmin Wang, Qing Li, et al. "Identification and Characterization of circRNAs in Non-Lactating Dairy Goat Mammary Glands Reveal Their Regulatory Role in Mammary Cell Involution and Remodeling." Biomolecules 13, no. 5 (2023): 860. http://dx.doi.org/10.3390/biom13050860.

Full text

Abstract:

This study conducted transcriptome sequencing of goat-mammary-gland tissue at the late lactation (LL), dry period (DP), and late gestation (LG) stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified in this study, of which 2528 circRNAs were expressed in all three stages. The number of exonic circRNAs was the largest, and the least identified circRNAs were antisense circRNAs. circRNA source gene analysis found that 9282 circRNAs were derived from 3889 genes, and 127 circRNAs’ source genes were un

APA, Harvard, Vancouver, ISO, and other styles

11

Zhang, Weixi, Zhengsai Yuan, Jing Zhang, et al. "Identification and Functional Prediction of CircRNAs in Leaves of F1 Hybrid Poplars with Different Growth Potential and Their Parents." International Journal of Molecular Sciences 24, no. 3 (2023): 2284. http://dx.doi.org/10.3390/ijms24032284.

Full text

Abstract:

Circular RNAs (CircRNAs) regulate plant growth and development; however, their role in poplar heterosis is unclear. We identified 3722 circRNAs in poplar leaves, most of which were intergenic (57.2%) and exonic (40.2%). The expression of circRNAs in F1 hybrids with high growth potential was higher than that in those with low growth potential. Non-additive expression of circRNAs and single-parent expression of circRNAs (SPE-circRNAs) might regulate poplar heterosis through microRNA sponging and protein translation, respectively. DECs among F1 hybrids with different growth potentials might regul

APA, Harvard, Vancouver, ISO, and other styles

12

Wang, Shuyuan, Peng Xia, Li Zhang, et al. "Systematical Identification of Breast Cancer-Related Circular RNA Modules for Deciphering circRNA Functions Based on the Non-Negative Matrix Factorization Algorithm." International Journal of Molecular Sciences 20, no. 4 (2019): 919. http://dx.doi.org/10.3390/ijms20040919.

Full text

Abstract:

Circular RNA (circRNA), a kind of special endogenous RNA, has been shown to be implicated in crucial biological processes of multiple cancers as a gene regulator. However, the functional roles of circRNAs in breast cancer (BC) remain to be poorly explored, and relatively incomplete knowledge of circRNAs handles the identification and prediction of BC-related circRNAs. Towards this end, we developed a systematic approach to identify circRNA modules in the BC context through integrating circRNA, mRNA, miRNA, and pathway data based on a non-negative matrix factorization (NMF) algorithm. Thirteen

APA, Harvard, Vancouver, ISO, and other styles

13

Xu, Ning, Shaomu Chen, Yufeng Liu, et al. "Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells." Cellular Physiology and Biochemistry 48, no. 5 (2018): 2046–60. http://dx.doi.org/10.1159/000492543.

Full text

Abstract:

Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological and pathological processes. In this study, we evaluated the roles of circRNAs in the chemoresistance of non-small cell lung cancer (NSCLC) to taxol. Methods: High-throughput circRNA microarrays were employed to investigate the circRNA profiles of parental A549 and taxol-resistant A549/Taxol cells. We predicted the miRNA targets of differentially expressed circRNAs via miRNA prediction software and then constructed a circRNA/miRNA network using Cytoscape. Bio

APA, Harvard, Vancouver, ISO, and other styles

14

Li, Peiyao, Zihao Xu, Tao Liu, et al. "Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis." Clinical Chemistry 68, no. 2 (2022): 332–43. http://dx.doi.org/10.1093/clinchem/hvab254.

Full text

Abstract:

Abstract Background Although major advances have been made in the histopathological diagnosis of high-grade astrocytoma (HGA), methods for effective and noninvasive diagnosis remain largely unknown. Exosomes can cross the blood–brain barrier and are readily accessible in human biofluids, making them promising biomarkers for HGA. Circular RNAs (circRNAs) have potential as tumor biomarkers owing to their stability, conservation, and tissue specificity. However, the landscape and characteristics of exosome circRNAs in HGA remain to be studied. Methods CircRNA deep sequencing and bioinformatics ap

APA, Harvard, Vancouver, ISO, and other styles

15

Wang, Xi, Yong Dai, Wanfan Zhang, S. SunDonglin, and Xinzhou Zhang. "Microarray based circRNA expression profiles in uremic plasma and PBMCs due to chronic glomerulonephritis." Archives of Biological Sciences 69, no. 3 (2017): 523–34. http://dx.doi.org/10.2298/abs160520128w.

Full text

Abstract:

Circular RNAs (circRNAs) have been identified in many diseases and shown to play important roles in pathological processes. The expression patterns of circRNA in uremia remains unknown. The aim of this study was to screen circRNA in plasma and peripheral blood mononuclear cells (PBMCs)in healthy controls and patients with uremia due to chronic glomerulonephritis, and to provide evidence for further exploration of the pathogenesis, diagnosis and treatment of uremic patients. Twenty individuals were included in this study, of which 10 were healthy and 10 were patients with uremia caused by chron

APA, Harvard, Vancouver, ISO, and other styles

16

Xu, Sheng, LuYu Zhou, Murugavel Ponnusamy, et al. "A comprehensive review of circRNA: from purification and identification to disease marker potential." PeerJ 6 (August 24, 2018): e5503. http://dx.doi.org/10.7717/peerj.5503.

Full text

Abstract:

Circular RNA (circRNA) is an endogenous noncoding RNA with a covalently closed cyclic structure. Based on their components, circRNAs are divided into exonic circRNAs, intronic circRNAs, and exon-intron circRNAs. CircRNAs have well-conserved sequences and often have high stability due to their resistance to exonucleases. Depending on their sequence, circRNAs are involved in different biological functions, including microRNA sponge activity, modulation of alternative splicing or transcription, interaction with RNA-binding proteins, and rolling translation, and are a derivative of pseudogenes. Ci

APA, Harvard, Vancouver, ISO, and other styles

17

Tagawa, Takanobu, Shaojian Gao, Vishal N. Koparde, et al. "Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA." Proceedings of the National Academy of Sciences 115, no. 50 (2018): 12805–10. http://dx.doi.org/10.1073/pnas.1816183115.

Full text

Abstract:

Noncoding RNAs have substantial effects in host–virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other RNAs or RNA-binding proteins to inhibit their functions. The role of circRNAs is largely unknown in the context of Kaposi’s sarcoma herpesvirus (KSHV). We hypothesized that circRNAs influence viral infection by inhibiting host and/or viral factors. Transcriptome analysis of KSHV-infected primary endothelial cells and a B cell line identified human circRNAs that are differentially regulated upon infection. We confirmed the expression changes

APA, Harvard, Vancouver, ISO, and other styles

18

Valladares-Ayerbes, Manuel, Carmen Garrigos, Miquel Taron, Angélica Figueroa, and Enrique Aranda. "Circular RNAs as biomarkers in liquid biopsy in colorectal cancer." Journal of Clinical Oncology 38, no. 4_suppl (2020): 230. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.230.

Full text

Abstract:

230 Background: Circular RNAs (circRNAs) are emerging as essential regulators of cancer- related biological hallmarks, as cell proliferation, apoptosis, differentiation, immune regulation and angiogenesis. CircRNAs are abundant, conserved, and have a tissue‐specific expression pattern. These characteristics make them candidate to serve as biomarkers in liquid biopsy (LB) in cancer. The aim of this study is to analyse differential expression of circRNAs in the colorectal cancer (CRC) scenario. Methods: To comprehensively understand the expression patterns of circRNAs we characterized 13,617 cir

APA, Harvard, Vancouver, ISO, and other styles

19

Yuan, Yu-Yi, Hui Wu, Qian-Yun Chen, Heng Fan, and Bo Shuai. "Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis." World Journal of Clinical Cases 12, no. 9 (2024): 1606–21. http://dx.doi.org/10.12998/wjcc.v12.i9.1606.

Full text

Abstract:

BACKGROUND Circular RNAs (circRNAs) are involved in the pathogenesis of many diseases through competing endogenous RNA (ceRNA) regulatory mechanisms. AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis (UC). METHODS We obtained gene expression profiles of circRNAs, miRNAs, and mRNAs in UC from the Gene Expression Omnibus dataset. The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions. Functional enrichment analysis was performed to

APA, Harvard, Vancouver, ISO, and other styles

20

Robic, Annie, Julie Demars, and Christa Kühn. "In-Depth Analysis Reveals Production of Circular RNAs from Non-Coding Sequences." Cells 9, no. 8 (2020): 1806. http://dx.doi.org/10.3390/cells9081806.

Full text

Abstract:

The sequencing of total RNA depleted for ribosomal sequences remains the method of choice for the study of circRNAs. Our objective was to characterize non-canonical circRNAs, namely not originating from back splicing and circRNA produced by non-coding genes. To this end, we analyzed a dataset from porcine testis known to contain about 100 intron-derived circRNAs. Labelling reads containing a circular junction and originating from back splicing provided information on the very small contribution of long non-coding genes to the production of canonical circRNAs. Analyses of the other reads reveal

APA, Harvard, Vancouver, ISO, and other styles

21

Wu, Hanwei, Yuchen Liu, Hongfang Duan, et al. "Identification of differentially expressed circular RNAs in human nasopharyngeal carcinoma." Cancer Biomarkers 29, no. 4 (2020): 483–92. http://dx.doi.org/10.3233/cbm-201731.

Full text

Abstract:

BACKGROUND: Circular RNAs (circRNAs) are endogenous RNAs that have a covalent closed cycle configuration. circRNAs have been found to be differentially expressed in many human cancers. Therefore, circRNAs may be ideal biomarkers for the diagnosis and treatment of cancer. However, we know very little about the function of circRNAs in nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the circRNA expression profiles in NPC. METHODS: We utilized high-throughput RNA sequencing (RNA-Seq) to evaluate the circRNA expression profile in NPC A total of 13,561 unique circRNA candid

APA, Harvard, Vancouver, ISO, and other styles

22

Li, Xiaohan, Bing Zhang, Fuyu Li, Kequan Yu, and Yunfei Bai. "The mechanism and detection of alternative splicing events in circular RNAs." PeerJ 8 (September 25, 2020): e10032. http://dx.doi.org/10.7717/peerj.10032.

Full text

Abstract:

Circular RNAs (circRNAs) are considered as functional biomolecules with tissue/development-specific expression patterns. Generally, a single gene may generate multiple circRNA variants by alternative splicing, which contain different combinations of exons and/or introns. Due to the low abundance of circRNAs as well as overlapped with their linear counterparts, circRNA enrichment protocol is needed prior to sequencing. Compared with numerous algorithms, which use back-splicing reads for detection and functional characterization of circRNAs, original bioinformatic analyzing tools have been devel

APA, Harvard, Vancouver, ISO, and other styles

23

Zhu, Zhongxin, Wenxi Du, Huan Yu, Hongting Jin, and Peijian Tong. "Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head." Disease Markers 2019 (November 15, 2019): 1–10. http://dx.doi.org/10.1155/2019/8759642.

Full text

Abstract:

Background. A growing number of studies have suggested that circular RNAs (circRNAs) serve as potential diagnostic biomarkers in many diseases. However, the role of circRNAs in steroid-induced osteonecrosis of the femoral head (SONFH) has not been reported. Methods. Secondary sequencing was performed to profile circRNA expression in peripheral blood samples from three SONFH patients and three healthy individuals. We confirmed our preliminary findings by qRT-PCR. Bioinformatics analysis was conducted to predict their functions. Results. The result showed 345 dysregulated circRNAs. qRT-PCR of ei

APA, Harvard, Vancouver, ISO, and other styles

24

Chen, Hong, Tao Wang, Zhiyou Gong, et al. "Low Light Conditions Alter Genome-Wide Profiles of Circular RNAs in Rice Grains during Grain Filling." Plants 11, no. 9 (2022): 1272. http://dx.doi.org/10.3390/plants11091272.

Full text

Abstract:

In animals and plants, circRNAs regulate gene expression and act as sponges that inhibit the activity of microRNAs. This study aimed to determine how specific circRNAs are expressed in rice grains at different stages of grain filling, under normal and low light conditions. We extracted total RNA from rice grains under low and sufficient light conditions. Deep sequencing was performed using circRNA libraries, and bioinformatics tools were used to identify the circRNAs. In addition, we analyzed targeted messenger RNA functions using two databases to predict the processes involved in rice grain d

APA, Harvard, Vancouver, ISO, and other styles

25

Bakhti, Seyedeh Zahra, Sana Dadashi, Anahita Dah Pahlevan, and Fatemeh Kafshresan. "Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review." International Clinical Neuroscience Journal 8, no. 4 (2021): 157–67. http://dx.doi.org/10.34172/icnj.2021.33.

Full text

Abstract:

Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis, apoptosis, and vascularization, are disrupted by an increased number of circRNAs. Recent research has showed that circRNAs, functioning as microRNA (miRNA) sponges or protein scaffolds, interacting with RNA-binding proteins (RBPs), and autophagy regulators, affect the transcription and splicing regulation. Many circRNAs have tissue-specific expre

APA, Harvard, Vancouver, ISO, and other styles

26

Sarkar, Debina, and Sarah D. Diermeier. "Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer." Non-Coding RNA 7, no. 1 (2021): 2. http://dx.doi.org/10.3390/ncrna7010002.

Full text

Abstract:

Circular RNAs (circRNAs) are a class of non-coding RNAs that form a covalently closed loop. A number of functions and mechanisms of action for circRNAs have been reported, including as miRNA sponge, exerting transcriptional and translational regulation, interacting with proteins, and coding for peptides. CircRNA dysregulation has also been implicated in many cancers, such as breast cancer. Their relatively high stability and presence in bodily fluids makes cancer-associated circRNAs promising candidates as a new biomarker. In this review, we summarize the research undertaken on circRNAs associ

APA, Harvard, Vancouver, ISO, and other styles

27

Buratin, Alessia, Maddalena Paganin, Enrico Gaffo, et al. "Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes." Blood Advances 4, no. 23 (2020): 5902–14. http://dx.doi.org/10.1182/bloodadvances.2020002337.

Full text

Abstract:

Abstract Circular RNAs (circRNAs) are stable RNA molecules that can drive cancer through interactions with microRNAs and proteins and by the expression of circRNA encoded peptides. The aim of the study was to define the circRNA landscape and potential impact in T-cell acute lymphoblastic leukemia (T-ALL). Analysis by CirComPara of RNA-sequencing data from 25 T-ALL patients, immature, HOXA overexpressing, TLX1, TLX3, TAL1, or LMO2 rearranged, and from thymocyte populations of human healthy donors disclosed 68 554 circRNAs. Study of the top 3447 highly expressed circRNAs identified 944 circRNAs

APA, Harvard, Vancouver, ISO, and other styles

28

Yao, Xiaocong, Minbo Liu, Fang Jin, and Zhongxin Zhu. "Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture." BioMed Research International 2020 (October 1, 2020): 1–13. http://dx.doi.org/10.1155/2020/4951251.

Full text

Abstract:

Aim. Circular RNAs (circRNAs) have been found to contribute to the regulation of many diseases and are abundantly expressed in various organisms. The present study is aimed at systematically characterizing the circRNA expression profiles in patients with senile osteoporotic vertebral compression fracture (OVCF) and predicting the potential functions of the regulatory networks correlated with these differentially expressed circRNAs. Methods. The circRNA expression profile in patients with senile OVCF was explored by using RNA sequencing. The prediction of the enriched signaling pathways and cir

APA, Harvard, Vancouver, ISO, and other styles

29

Conn, Vanessa M., Marta Gabryelska, Shashikanth Marri, et al. "SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion." Cells 9, no. 11 (2020): 2488. http://dx.doi.org/10.3390/cells9112488.

Full text

Abstract:

High-throughput RNA sequencing (RNA-seq) and dedicated bioinformatics pipelines have synergized to identify an expansive repertoire of unique circular RNAs (circRNAs), exceeding 100,000 variants. While the vast majority of these circRNAs comprise canonical exonic and intronic sequences, microexons (MEs)—which occur in 30% of functional mRNA transcripts—have been entirely overlooked. CircRNAs which contain these known MEs (ME-circRNAs) could be identified with commonly utilized circRNA prediction pipelines, CIRCexplorer2 and CIRI2, but were not previously recognized as ME-circRNAs. In addition,

APA, Harvard, Vancouver, ISO, and other styles

30

Huang, Jin, Yanli Wang, Jie Yu, et al. "Evolutionary Landscape of Tea Circular RNAs and Its Contribution to Chilling Tolerance of Tea Plant." International Journal of Molecular Sciences 24, no. 2 (2023): 1478. http://dx.doi.org/10.3390/ijms24021478.

Full text

Abstract:

Chilling stress threatens the yield and distribution pattern of global crops, including the tea plant (Camellia sinensis), one of the most important cash crops around the world. Circular RNA (circRNA) plays roles in regulating plant growth and biotic/abiotic stress responses. Understanding the evolutionary characteristics of circRNA and its feedbacks to chilling stress in the tea plant will help to elucidate the vital roles of circRNAs. In the current report, we systematically identified 2702 high-confidence circRNAs under chilling stress in the tea plant, and interestingly found that the gene

APA, Harvard, Vancouver, ISO, and other styles

31

Chen, Qingshi, Jiayu Lin, Zhiyu Chen, Lishuang Che, and Dexin Liu. "Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis." PLOS ONE 18, no. 4 (2023): e0284459. http://dx.doi.org/10.1371/journal.pone.0284459.

Full text

Abstract:

Objectives Increasing studies have shown that circular RNAs (circRNAs) participate in the pathogenesis and progression of many diseases. However, the function of circRNAs in obstructive sleep apnea (OSA)-induced pancreatic damage has not been fully elucidated. In this study, the altered circRNA profiles in a chronic intermittent hypoxia (CIH) mouse model were investigated, aiming to provide novel clues for delineating the underlying mechanisms of OSA-induced pancreatic injury. Methods A CIH mouse model was established. circRNA microarray was then applied to profile circRNA expression in pancre

APA, Harvard, Vancouver, ISO, and other styles

32

Li, Ai, Wanlong Huang, Xiuxiu Zhang, Lingli Xie, and Xiangyang Miao. "Identification and Characterization of CircRNAs of Two Pig Breeds as a New Biomarker in Metabolism-Related Diseases." Cellular Physiology and Biochemistry 47, no. 6 (2018): 2458–70. http://dx.doi.org/10.1159/000491619.

Full text

Abstract:

Background/Aims: CircRNAs, as miRNA sponges, participate in many important biological processes. However, it remains unclear whether circRNAs can regulate lipid metabolism. This paper aims to study the molecular mechanism of fat deposition and provide useful information for the prevention and therapy of lipid metabolism-related diseases. Methods: CircRNA sequencing was performed to investigate the expression of circRNAs in the subcutaneous adipose tissues of Large White pig and Laiwu pig. The expression of circRNAs was further validated by quantitative reverse transcription polymerase chain re

APA, Harvard, Vancouver, ISO, and other styles

33

Van Der Steen, Nele, Yanhong Lyu, Anne K. Hitzler, Andrea C. Becker, Jeanette Seiler, and Sven Diederichs. "The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells." Cancers 12, no. 5 (2020): 1091. http://dx.doi.org/10.3390/cancers12051091.

Full text

Abstract:

The class of circular RNA (circRNA) is characterized by head-to-tail bonds between exons formed by backsplicing. Here, we provide a resource of circRNA expression in a comprehensive panel of 60 lung cancer and non-transformed cell lines (FL3C dataset). RNA sequencing after depletion of ribosomal RNA quantified the expression of circRNA and linear RNA. We detected 148,811 circular RNAs quantified by 2.8 million backsplicing reads originating from 12,251 genes. The number of identified circRNAs was markedly higher using rRNA depletion compared to public polyA-enriched RNA-seq datasets. CircRNAs

APA, Harvard, Vancouver, ISO, and other styles

34

Gao, Yuan, Mingli Wu, Yingzhi Fan, et al. "Identification and characterization of circular RNAs in Qinchuan cattle testis." Royal Society Open Science 5, no. 7 (2018): 180413. http://dx.doi.org/10.1098/rsos.180413.

Full text

Abstract:

Circular RNA (circRNA) is a new class of non-coding RNA that has recently attracted researchers' interest. Studies have demonstrated that circRNA can function as microRNA sponges or competing endogenous RNAs. Although circRNA has been explored in some species and tissues, the genetic basis of testis development and spermatogenesis in cattle remains unknown. We performed ribo-depleted total RNA-Seq to detect circRNA expression profiles of neonatal (one week old) and adult (4 years old) Qinchuan cattle testes. We obtained 91 112 596 and 80 485 868 clean reads and detected 21 753 circRNAs. A tota

APA, Harvard, Vancouver, ISO, and other styles

35

Yang, Zhenchao, Zhao Yang, Yingge Xie, Qi Liu, Yanhao Mei, and Yongjun Wu. "Systematic Identification and Analysis of Light-Responsive Circular RNA and Co-expression Networks in Lettuce (Lactuca sativa)." G3: Genes|Genomes|Genetics 10, no. 7 (2020): 2397–410. http://dx.doi.org/10.1534/g3.120.401331.

Full text

Abstract:

Circular RNA (circRNA) is a covalently-closed single-stranded RNA molecule that plays an important role in transcriptional regulation of gene expression in a variety of species. Light intensity is a pivotal environmental factor affecting plant growth and development. However, little is known regarding photoresponsive plant circRNAs. Here, we aimed to investigate the expression and function of circRNAs in lettuce leaves in response to different light intensity treatments. We performed RNA sequencing (RNA-Seq) on leaves of lettuce (Lactuca sativa) to determine circRNA expression profiles and rev

APA, Harvard, Vancouver, ISO, and other styles

36

Lan, Xiabin, Jiajie Xu, Chao Chen, et al. "The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing." Cellular Physiology and Biochemistry 47, no. 3 (2018): 1122–32. http://dx.doi.org/10.1159/000490188.

Full text

Abstract:

Background/Aims: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. However, the molecular mechanisms responsible for its tumorigenesis and progression remain largely unknown. Circular RNA (circRNA) is a novel type of noncoding RNA that can serve as an ideal biomarker due to its stability. Recent evidence suggests that circRNAs play important roles in tumorigenesis. This study aims to investigate circRNA expression profiles and their potential biological functions in PTC. Methods: High-throughput RNA sequencing was used to assess circRNA expression profiles in PTC, an

APA, Harvard, Vancouver, ISO, and other styles

37

Xu, Xiaorong, Yufeng Xiao, Ximin Zhang, Ming Tang, and Jing Tang. "Identification and Characterization of Circular RNAs Involved in the Flower Development and Senescence of Rhododendron delavayi Franch." International Journal of Molecular Sciences 23, no. 19 (2022): 11214. http://dx.doi.org/10.3390/ijms231911214.

Full text

Abstract:

Floral development and senescence are a crucial determinant for economic and ornamental value. CircRNAs play an essential role in regulating plant growth and development; however, there is no systematic identification of circRNAs during the lifespan of flowers. This study aims to explore the expression profile and functional role of circRNAs in the full flowering stages of Rhododendron delavayi Franch. We carried out transcriptome sequencing of the six stages of Rhododendron delavayi Franch flowers to identify the circular RNA expression profile. In addition, using bioinformatics methods, we e

APA, Harvard, Vancouver, ISO, and other styles

38

Liu, Jiqing, Xuelin Zhao, Xuemei Duan, Weiwei Zhang, and Chenghua Li. "CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus." Frontiers in Immunology 12 (November 17, 2021). http://dx.doi.org/10.3389/fimmu.2021.770055.

Full text

Abstract:

Circular RNAs (circRNAs) act as essential regulators in many biological processes, especially in mammalian immune response. Nonetheless, the functions and mechanisms of circRNAs in the invertebrate immune system are largely unclarified. In our previous work, 261 differentially expressed circRNAs potentially related to the development of Apostichopus japonicus skin ulceration syndrome (SUS), which is a major problem restricting the sea cucumber breeding industry, were identified by genome-wide screening. In this study, via miRanda analysis, both circRNA75 and circrRNA72 were shown to share the

APA, Harvard, Vancouver, ISO, and other styles

39

Liu, Tian-yi, Hui Feng, Salsabeel Yousuf, Ling-li Xie, and Xiang-yang Miao. "Functional analysis of differentially expressed circular RNAs in sheep subcutaneous fat." BMC Genomics 24, no. 1 (2023). http://dx.doi.org/10.1186/s12864-023-09401-6.

Full text

Abstract:

Abstract Background Circular RNAs (circRNAs), as important non-coding RNAs (ncRNAs), are involved in many biological activities. However, the exact chemical mechanism behind fat accumulation is unknown. In this paper, we obtained the expression profiles of circRNAs using high-throughput sequencing and investigated their differential expression in subcutaneous fat tissue of Duolang and Small Tail Han sheep. Results From the transcriptomic analysis, 141 differentially expressed circRNAs were identified, comprising 61 up-regulated circRNAs and 80 down-regulated circRNAs. These host genes were pri

APA, Harvard, Vancouver, ISO, and other styles

40

Zhang, Haojie, Baoyu Hu, Jiali Xiong, et al. "Genomewide analysis of circular RNA in pituitaries of normal and heat-stressed sows." BMC Genomics 20, no. 1 (2019). http://dx.doi.org/10.1186/s12864-019-6377-7.

Full text

Abstract:

Abstract Background As a newly characterized type of noncoding RNA, circular RNA (circRNA) has been shown to have functions in diverse biological processes of animals. It has been reported that several noncoding RNAs may regulate animals’ response to heat stress which can be easily induced by hyperthermia in summer. However, the expression and functions of circRNAs in the pituitary of sows and whether they participate in heat stress adaption are still unclear. Results In this study, we found that high temperature over the thermoneutral zone of sows during the summer increased the serum heat sh

APA, Harvard, Vancouver, ISO, and other styles

41

Fang, Zhixiao, Chunjie Jiang, and Shengli Li. "The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy." Frontiers in Immunology 11 (February 3, 2021). http://dx.doi.org/10.3389/fimmu.2020.617583.

Full text

Abstract:

Circular RNAs (circRNAs) are covalently closed RNA molecules in eukaryotes with features of high stability, tissue-specific and cell-specific expression. According to their biogenesis, circRNAs are mainly classified into five types, i.e. exonic circRNAs (EciRNAs), exon-intron circRNAs (EIciRNAs), intronic RNAs (CiRNAs), fusion circRNAs (f-circRNAs), and read-through circRNAs (rt-circRNAs). CircRNAs have been emerging as important non-coding regulatory RNAs in a variety of human cancers. CircRNA4s were revealed to exert regulatory function through multiple mechanisms, such as sponges/decoys of

APA, Harvard, Vancouver, ISO, and other styles

42

Zhao, Min, and Hong Qu. "circVAR database: genome-wide archive of genetic variants for human circular RNAs." BMC Genomics 21, no. 1 (2020). http://dx.doi.org/10.1186/s12864-020-07172-y.

Full text

Abstract:

Abstract Background Circular RNAs (circRNAs) play important roles in regulating gene expression through binding miRNAs and RNA binding proteins. Genetic variation of circRNAs may affect complex traits/diseases by changing their binding efficiency to target miRNAs and proteins. There is a growing demand for investigations of the functions of genetic changes using large-scale experimental evidence. However, there is no online genetic resource for circRNA genes. Results We performed extensive genetic annotation of 295,526 circRNAs integrated from circBase, circNet and circRNAdb. All pre-computed

APA, Harvard, Vancouver, ISO, and other styles

43

Fang, Guida, Dalai Xu, Tao Zhang, et al. "Biological functions, mechanisms, and clinical significance of circular RNA in colorectal cancer." Frontiers in Oncology 13 (March 6, 2023). http://dx.doi.org/10.3389/fonc.2023.1138481.

Full text

Abstract:

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide due to the lack of effective diagnosis and prognosis biomarkers and therapeutic targets, resulting in poor patient survival rates. Circular RNA (circRNA) is a type of endogenous non-coding RNA (ncRNA) with a closed-loop structure that plays a crucial role in physiological processes and pathological diseases. Recent studies indicate that circRNAs are involved in the diagnosis, prognosis, drug resistance, and development of tumors, particularly in CRC. Therefore, circRNA could be a potential new target for improving CRC

APA, Harvard, Vancouver, ISO, and other styles

44

Wang, Yongtian, Xinmeng Liu, Yewei Shen, et al. "Collaborative deep learning improves disease-related circRNA prediction based on multi-source functional information." Briefings in Bioinformatics, February 27, 2023. http://dx.doi.org/10.1093/bib/bbad069.

Full text

Abstract:

Abstract Emerging studies have shown that circular RNAs (circRNAs) are involved in a variety of biological processes and play a key role in disease diagnosing, treating and inferring. Although many methods, including traditional machine learning and deep learning, have been developed to predict associations between circRNAs and diseases, the biological function of circRNAs has not been fully exploited. Some methods have explored disease-related circRNAs based on different views, but how to efficiently use the multi-view data about circRNA is still not well studied. Therefore, we propose a comp

APA, Harvard, Vancouver, ISO, and other styles

45

Zhong, Huan, Zhongbao Guo, Jun Xiao, Hong Zhang, Yongju Luo, and Junneng Liang. "Comprehensive Characterization of Circular RNAs in Ovary and Testis From Nile Tilapia." Frontiers in Veterinary Science 9 (April 6, 2022). http://dx.doi.org/10.3389/fvets.2022.847681.

Full text

Abstract:

Circular RNA (circRNA) is an endogenous biomolecule in eukaryotes. It has tissue- and cell-specific expression patterns and can act as a microRNA sponge or competitive endogenous RNA. Although circRNA has been found in several species in recent years, the expression profiles in fish gonad are still not fully understood. We detected the expression of circRNA in the ovary, testis, and sex-changed gonad of tilapia by high-throughput deep sequencing, and circRNA-specific computing tools. A total of 20,607 circRNAs were obtained, of which 141 were differentially expressed in the testis and ovary. A

APA, Harvard, Vancouver, ISO, and other styles

46

Ruan, Zhong-bao, Fei Wang, Qiu-ping Yu, Ge-cai Chen, and Li Zhu. "Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-77485-1.

Full text

Abstract:

AbstractWe aimed to investigate the circRNA–miRNA regulatory network in atrial fibrillation (AF) by using Cytoscape and HMDD v3.0. Finally, 120 differentially expressed circRNAs in peripheral blood monocytes of 4 AF patients were preliminarily screened by circRNA microarray. circRNA_4648, circRNA_4631, and circRNA_2875 were the first four circRNAs with the most binding nodes in the circRNA–miRNA network. The top three most frequent miRNAs for up-regulated circRNAs were hsa-miR-328 that interacted with 5 up-regulated circRNAs, hsa-miR-4685-5p with 4 up-regulated circRNAs, hsa-miR-3150a-3p, hsa-

APA, Harvard, Vancouver, ISO, and other styles

47

Feng, Xin-Yi, Shun-Xin Zhu, Ke-Jia Pu, Heng-Jing Huang, Yue-Qin Chen, and Wen-Tao Wang. "New insight into circRNAs: characterization, strategies, and biomedical applications." Experimental Hematology & Oncology 12, no. 1 (2023). http://dx.doi.org/10.1186/s40164-023-00451-w.

Full text

Abstract:

AbstractCircular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing. Advanced high-throughput RNA sequencing and experimental technologies have enabled the extensive identification and characterization of circRNAs, such as novel types of biogenesis, tissue-specific and cell-specific expression patterns, epigenetic regulation, translation potential, localization and metabolism. Increasing evidence has revealed that circRNAs participate in diverse cellular processes, and their dysregulati

APA, Harvard, Vancouver, ISO, and other styles

48

Li, Huihui, Mingzhe Xie, Yan Wang, Ludong Yang, Zhi Xie, and Hongwei Wang. "riboCIRC: a comprehensive database of translatable circRNAs." Genome Biology 22, no. 1 (2021). http://dx.doi.org/10.1186/s13059-021-02300-7.

Full text

Abstract:

AbstractriboCIRC is a translatome data-oriented circRNA database specifically designed for hosting, exploring, analyzing, and visualizing translatable circRNAs from multi-species. The database provides a comprehensive repository of computationally predicted ribosome-associated circRNAs; a manually curated collection of experimentally verified translated circRNAs; an evaluation of cross-species conservation of translatable circRNAs; a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function; and a genome browser to visualize the context-spe

APA, Harvard, Vancouver, ISO, and other styles

49

Lai, Suxian, Lijun Chen, Pingyun Zhan, et al. "Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis." Frontiers in Cell and Developmental Biology 9 (November 8, 2021). http://dx.doi.org/10.3389/fcell.2021.767283.

Full text

Abstract:

Circular RNAs (circRNAs) participate in the development of various kinds of diseases. However, the function and roles of circRNAs in obstructive sleep apnea (OSA)-induced cardiovascular disease remain poorly understood. Therefore, we sought to explore the circRNA expression profiles and predict their functions in OSA-induced cardiac injury with the use of bioinformatics analysis. The model of OSA was established in mouse treated by chronic intermittent hypoxia (CIH) exposure. Then, we screened the circRNA profile using circRNA microarray. By comparing circRNA expression in three matched pairs

APA, Harvard, Vancouver, ISO, and other styles

50

Sun, Handong, Zijuan Wu, Ming Liu, et al. "CircRNA May Not Be “Circular”." Frontiers in Genetics 12 (February 19, 2021). http://dx.doi.org/10.3389/fgene.2021.633750.

Full text

Abstract:

Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (ICBPS) existed in plenty of circRNAs, especially in extremely long circRNAs (el-circRNAs, &gt; 5,000 nt). The result indicated that circRNA may not be a simple circular structure. In addition, we put forward the hypothesis of “open-close eff

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!