Dissertations / Theses on the topic 'Circulation of texts'

This is a work about the publications and archival habits of a radical minority. The Quakers organised themselves around reading, writing, archiving, and publication— activities in which every member was expected to participate. The paradox of these activities is that while they focused upon individual spiritual development, they were dependent upon and tested by intensely collaborative authorship and communal reading. Reading amongst Friends was an element of their spiritual identity, and also a direct inheritance of changes in information production and circulation triggered during the Civil Wars of the 1640s. Over time, Quaker reading practices changed along with the publications they produced and circulated, especially at the onset of state-sanctioned persecution during the Restoration. Publications, which initially featured Quaker leaders as authors, extended to include the testimonies of the broader membership experiencing persecution. Alternate readings of Quaker texts fuelled the doctrinal disputes between members. So too did the makeup of membership change, widening audiences, attracting scholars on the one hand, and non-English speakers on the other. Within current scholarship on the history of reading, Quakers show how individual readings developed in a communal environment. Within the study of book history, Quakers show how the uses of print were integrated with the uses of manuscript, and they offer insight into the role oral discussion plays in “reading,” which in turn, has shaped the outcome of what has survived. Finally, within religious history, the purpose of this thesis is to detail what it meant for men and women at the end of the 17th century to document their experience of revolutionary religious fervour of the Civil War period in its aftermath — and how that fervour structured the production and circulation of texts for centuries to come.

This study explores the literature of late Choson in its material context, examining how the physical aspects of the production and circulation of texts impacted the practice of writing. By analyzing various travelogues from Beijing (yonhaengnok) and private collections (munjip) from the late seventeenth to the early nineteenth century, I examine how transcultural contacts across borders and changing textual environments influenced intellectual circles and literary trends in late Choson Korea. Interpreting the literary text as the material product of a culture, my study shifts the emphasis from the author as the creator of a text to the editors, publishers, collectors, and readers, through whose hands a text is reshaped and given new meaning. In light of the concept of social authorship, the written culture of late Choson will be revisited in relation to complex networks of social interactions. The print and manuscript culture of the day, socio-political groups that the author belonged to, the book market, and the government policies of that time provide interesting information on the practices of literary production, based on the larger cultural dynamics of East Asia. This dissertation revolves around a series of questions about circulation networks and their impact. In regard to the social and cultural condition of literary production in the eighteenth century, I examine transnational interactions with foreign intellectuals as well as collective coterie activities of reading and writing among the literati in Seoul. How did the flourishing of print culture of the Jiangnan area and the book markets in Beijing change the textual dynamics of Korea? Did the government censorship carried out by the Qing and the Choson governments effectively control the circulation of books? How did the Choson literati consume the foreign books and why did they form so many literary communities in Seoul? By investigating the large scope of these textual situations, I explore how the transcultural contacts "across borders" and the changing textual environments influenced intellectual circles and literary trends in late Choson. With respect to textual dynamics, I emphasize the various "informal networks" that have been placed at the center of book reception and consumption. For example, a number of book brokers in the Qing and Choson facilitated the distribution of books, and the sharing of manuscripts among friends in literary coteries was influential in the shaping of new literary tastes and public culture. These unconventional routes outside of established channels functioned as the actual key drivers of book culture in late Choson. My argument throughout this dissertation is that "informal circulation" is a central, rather than marginal, feature of eighteenth-century book culture and literary production. Through a specific case study of a literatus-official, Yi Tong-mu (1741-1793), my dissertation addresses these issues in three parts that consist of seven chapters: (1) Part One, "Social Authorship and Manuscript Production," examines how the writings of Yi Tong-mu were constructed and transmitted through a complex of social interactions and how the physical aspects of texts inform various transactions of human and non-human agencies in the production of texts. (2) Part Two, "The Location of Texts: Circulation of Books, Censorship, and Community Activities" traces how social networks among the domestic literati as well as among foreign intellectuals facilitated the circulation of books. First, I examine the large scope of transnational interaction between China and Korea, and the literary inquisition carried out by the Choson government in response to the changing textual environment. This is followed by a discussion of the poetry communities in Seoul, in which the Choson literati shared their reading practices and produced their common aesthetic tastes in their writings. (3) Part Three, "Making Meaning: Reading Self and Social Discourses," examines how Yi Tong-mu read books from the Ming and the Qing--such as those by Yuan Hongdao of the Ming and Wang Shizhen of the Qing--and wrote his own poetry and literary criticism and embodied his interpretive activities in his own works.
East Asian Languages and Civilizations

La collection de sermons ad status du maître franciscain Guibert de Tournai († 1284), inscrite dans le nouvel art de prêcher qui se développe au XIIIe siècle, est surtout connue pour la particularité de son organisation, qui répartit les sermons selon les états de vie d'auditoires plutôt que selon les occasions du temps liturgique. Cette thèse réalise un bilan et une actualisation des connaissances sur l'auteur et la collection, ainsi qu'une analyse approfondie de cette œuvre, assortie d'une transcription intégrale. Elle ouvre également la voie d'une réinterprétation du remploi littéraire chez Guibert de Tournai, et propose une lecture nouvelle du découpage ad status à la lumière de la mnémotechnique et des arts de la mémoire. Le premier chapitre fait un bilan des connaissances sur Guibert de Tournai. Enfant de la bourgeoisie flamande, il reste fidèle à sa terre d'origine et aux hommes qu'il a connus ici, bien longtemps après que ses études et son engagement dans l'ordre franciscain l'ont amené à Paris. Intellectuel fécond dans des genres variés, son œuvre laisse entrevoir une personnalité éprise de mystique et de contemplation. Personnage proéminent dans le paysage intellectuel parisien des années 1260, en relation avec de grands personnages politiques et intellectuels de son temps, il s'intéresse aussi aux questions de formation et de transmission du savoir, et bien évidemment à la prédication que nous le voyons pratiquer, grâce à des reportations parisiennes, jusqu'au soir de sa vie. Le deuxième chapitre est consacré à la présentation et l'analyse détaillées de la collection ad status. La tradition en est foisonnante, compliquée par quelques accidents conjoncturels dans la transmission du texte. Elle laisse tout de même entrevoir un texte qui semble relativement stable. Dans son contenu, systématiquement analysé, la collection est un bel exemple de « sermons modernes » dans sa manière d'arranger la matière prêchable, en se servant de très nombreuses distinctiones pour structurer les textes. Le troisième chapitre explore le rapport de Guibert à l'intertextualité ou « remploi » littéraire. Le maître franciscain puise volontiers sa matière dans d'autres œuvres : son remploi des Sermones vulgares de Jacques de Vitry dans ses sermons ad status est connu de longue date, mais il a aussi trouvé chez Guillaume d'Auvergne une partie de la matière première des sermons sur les sacrements. Les emprunts à Jacques de Vitry, mesurés grâce à l'indicateur des exempla, se révèlent moins systématiques et plus complexes qu'on aurait pu le penser, montrant à quel point le remploi littéraire faisait partie intégrante du processus de création, pour Guibert comme pour d'autres auteurs médiévaux. Le rôle des œuvres de Guibert comme réservoirs de matière, faisant à leur tour l'objet de remploi dans des œuvres de genres et d'auteurs variés, est également mis en évidence dans une série de textes. Le dernier chapitre enfin propose une nouvelle lecture du choix d'organisation ad status de la collection, une interprétation alternative du projet de Guibert. Plutôt qu'un miroir de la société réelle ou idéale du prédicateur, la composition de sermons selon des états de vie de l'auditoire peut être comprise, à la lumière des arts de la mémoire, comme un ingénieux outil mnémotechnique pour l'organisation de la matière prêchable. En faisant des status des « lieux de mémoire », Guibert a réalisé une classification thématique de la matière prêchable selon les topoi attachés aux états de vie
The collection of ad status sermons by the Franciscan Guibert de Tournai (d. 1284), rooted in the new art of preaching that was developing in the thirteenth century, is best known for its particular organization, arranging the sermons according to the social position (or estate) of their audience rather than by liturgical occasions. This thesis assesses and updates our knowledge of the author and the collection, and provides an in-depth analysis of this body of work, accompanied by a complete transcription. Furthermore, the thesis paves the way for a reinterpretation of the ways in which Guibert used and adapted earlier texts, and it proposes a new understanding of the ad status division, in light of mnemonics and the art of memory.The first chapter assesses our knowledge of Guibert de Tournai. A child of the Flemish bourgeoisie, he remained faithful to his land of origin and to the men he knew there, long after his studies and his engagement in the Franciscan order had led him to Paris. Intellectually fertile in a variety of genres, his works hint at a personality passionate about mysticism and contemplation. A pre-eminent figure in the Parisian intellectual landscape of the 1260s, connected to the key political and intellectual figures of his time, he was interested in questions regarding the acquisition and transmission of knowledge, and evidently in the preaching we know – thanks to Parisian reportationes – that he practiced until his twilight years.The second chapter offers a detailed presentation and analysis of the ad status collection. There are many extant manuscripts, and their analysis is complicated by several inconsistencies in the transmission of the work, but overall and over time the text seems relatively stable. The content of the collection, systematically analysed, provides an excellent example of the “modern sermon” in the way it arranges the material for preaching, drawing on numerous distinctiones to structure the texts.The third chapter explores the link between Guibert and intertextuality or textual reuse. The Franciscan master took much of his material from other works; his reuse of the Sermones vulgares of Jacques de Vitry in his ad status sermons has been known for a long time, but he also found much of his preaching material for sermons on the sacraments in the work of Guillaume d’Auvergne. Guibert's appropriation of the work of Jacques de Vitry, measured through the use of his predecessor's exempla, is revealed to be less systematic and more complex than scholars would otherwise have predicted, demonstrating just how, and to what extent, textual reuse was integral to the creation process for Guibert as well as for other medieval authors. The role of the works of Guibert as reservoirs of material, in turn themselves reused in works of various genres and authors, is demonstrated through the analysis of a number of later texts.The final chapter proposes a new consideration of Guibert's choice of constructing his collection as an ad status text. The composition of sermons according to the social position of the audience can be understood, in light of the art of memory, as an ingenious mnemonic tool for the organisation of preaching material rather than as a mirror of a real or ideal society. In turning the status into “lieux de mémoire”, Guibert created a thematic classification of preaching material according to topoi attached to the estates

Cette thèse se propose de réévaluer le statut des sources ibériques au sein d’un corpus de pièces anglaises jouées entre la fin du règne d’Élisabeth Ie et le début de l’ère jacobéenne, période marquée par de profonds changements socio-culturels. Elle se concentre non pas sur la tension bien connue et souvent étudiée entre hispanophilie et hispanophobie qui caractérise alors la représentation des relations anglo-ibériques, mais envisage ce rapport selon une perspective textuelle, culturelle et esthétique incluant les relais qui, à l’échelle européenne, permettaient à ces textes de circuler, tout en les modifiant. Ce travail porte donc sur les réseaux d’influence des textes ibériques de la culture de cour des XVe et XVIe siècles, et leur impact sur le théâtre anglais de la première modernité. Il aborde notamment le roman sentimental Tractado de amores de Arnalte y Lucenda de Diego de San Pedro, la poésie de cour de Juan Boscán et Garcilaso de la Vega avec le long poème Leandro et le sonnet XXIX « Pasando el mar Leandro el animoso », la romance pastorale Los siete libros de La Diana de Jorge de Montemayor et le récit picaresque publié anonymement, La vida de Lazarillo de Tormes, y de sus fortunas y adversidades. Ces œuvres sont mises en dialogue avec des textes didactiques et philosophiques tels que El libro aureo de Marco Aurelio d’Antonio de Guevara, Le Courtisan de Baldassare Castiglione traduit par Boscán et El Examen de Ingenios de Juan Huarte de San Juan, qui s’intéressent tous à la figure du courtisan et à la notion de « service ». Quant au corpus de textes dramatiques anglais privilégiés dans cette étude, il est principalement constitué de pièces de Shakespeare, en particulier de The Two Gentlemen of Verona, Love’s Labour’s Lost, The Merry Wives of Windsor, Twelfth Night et The Winter’s Tale. Ces œuvres sont mises en relation avec d’autres écrits contemporains : Hero and Leander de Christopher Marlowe, Blurt Master Constable de Thomas Dekker, ainsi que des textes de John Lyly et de Ben Jonson. En complétant et réorientant les études portant sur les intrigues et les personnages de la littérature dramatique anglaise, champ d’investigation traditionnel des Source Studies, cette thèse aborde ces éléments selon une approche qui prend en compte les perspectives sociétales et théâtrales inhérentes à la littérature issue de la société de cour ibérique : cette littérature innovante reflète, façonne et interroge tout particulièrement la théâtralité d’un milieu où les individus ne cessent de se mettre en scène. Tour à tour auteurs, dédicataires et personnages-clés de ces fictions dont ils sont très friands, les membres de la société de cour ibérique fournissent ainsi aux écrivains anglais de la première modernité un terrain de jeu propice à l’innovation et à l’expérimentation dramaturgiques
This dissertation proposes to reassess the status of Iberian sources within a corpus of English plays staged between the last years of the reign of Elizabeth I and the beginning of the Jacobean era, a period marked by deep socio-cultural changes. It does not focus on the well-known and often studied tension between Hispanophilia and Hispanophobia which characterises the representation of Anglo-Iberian relations at the time, but considers this relationship from a textual, cultural and aesthetic perspective including the go-betweens that, at a European scale, enabled these texts to circulate while they were altering them. This work thus deals with the networks of influence of Iberian texts belonging to 15th-and-16th-century court culture and the impact they had on early modern English drama. In particular, it tackles the sentimental romance Tractado de amores de Arnalte y Lucenda by Diego de San Pedro, court poetry by Juan Boscán and Garcilaso de la Vega with the long poem Leandro and sonnet XXIX « Pasando el mar Leandro el animoso », the pastoral romance Los siete libros de La Diana by Jorge de Montemayor and the anonymously published picaresque tale La vida de Lazarillo de Tormes, y de sus fortunas y adversidades. These works are set in conversation with didactic and philosophical texts such as El libro aureo de Marco Aurelio by Antonio de Guevara, The Courtier by Baldassare Castiglione translated by Boscán and El Examen de Ingenios by Juan Huarte de San Juan: they all deal with the figure of the courtier and the notion of « service ». As to the corpus of English dramatic texts chosen for this study, it is mainly composed of plays by Shakespeare, notably The Two Gentlemen of Verona, Love’s Labour’s Lost, The Merry Wives of Windsor, Twelfth Night et The Winter’s Tale. These works are related to other contemporary writings: Hero and Leander by Christopher Marlowe, Blurt Master Constable by Thomas Dekker, along with texts by John Lyly and Ben Jonson. By supplementing and redirecting the studies addressing plots and characters in the English dramatic literature, the traditional field of investigation of Source Studies, this dissertation discusses these elements from a perspective which takes into account the societal and theatrical dimensions inherent to the literature born out of the Iberian court society : this innovative literature reflects, shapes and questions especially the theatricality of an environment where individuals never cease to stage themselves. Alternately authors, dedicatees and key-characters and figures of these fictions they enjoy thoroughly, the members of the Iberian court society thus provide early modern English writers with a playground conducive to dramaturgical innovation and experimentation

Following recent critical work on writers' representations of sociability in Romantic literature, this thesis examines in detail the textual strategies (such as allusion, acts of address, and the use of 'coterie' symbols or references) which writers used to seek to establish a friendly or sympathetic relationship with a particular reader or readers, or to create and define a sense of community identity between readers. The thesis focuses on specific relationships between pairs and groups of writers (who form one another's first readers), and examines 'sociable' genres like letters, manuscript albums, occasional poetry, and periodical essays in a diverse series of author case-studies (Anna Barbauld, Samuel Taylor Coleridge, Charles Lamb, John Keats and Leigh Hunt). Such genres, the thesis argues, show how manuscript and print culture could frequently overlap and intersect, meaning that writers confronted the demands of two co-existing audiences - one private and familiar, the other public and unknown - in the same work. Rather than arguing that writers used manuscript culture practices and produced 'coterie' works purely to avoid confronting their anxieties about publishing in the commercial sphere of print culture, the thesis suggests that in producing such 'coterie' works writers engaged with and reflected contemporary philosophical and political concerns about the relationship between the individual and wider communities. In these works, writers engaged with the legacy of eighteenth-century philosophical ideas about the role (and limitations) of the sympathetic imagination in maintaining social communities, and with interpretative theories about the best kind of reader. Furthermore, the thesis argues that reading literary texts in the specific, material context in which they are 'published' to particular readers, either in print, manuscript, or letters, is vital to understanding writer/reader relationships in the Romantic period. This approach reveals how within each publication space, individual texts could be placed (either by their writers, by editors, or by other readers) in meaningful relationships with other texts, absorbing or appropriating them into new interpretative contexts.

L’influence littéraire exercée par l'Espagne du Siècle d’or sur la France du premier XVIIe siècle est liée à un ample mouvement éditorial. Cette thèse, qui associe histoire du livre et histoire littéraire, étudie les traductions françaises de textes espagnols qui ont circulé en France entre 1600 et 1660 – traductions qui concernent des textes de toute nature (religieux, littéraires, scientifiques, techniques...). Pour évaluer l’ampleur de ce mouvement éditorial, une enquête bibliométrique est d’abord réalisée. Elle permet de reconstituer l’histoire de cette diffusion par l’imprimé. On identifie les principaux foyers de production et on examine la production des officines de librairie engagées dans ce marché. L’analyse se porte ensuite sur l’activité de traduction elle-même, dans la diversité de ses pratiques. Les profils des principaux traducteurs d’espagnol en français sont distingués : le traducteur professionnel, l’amateur éclairé, l’imprimeur, le religieux, le médecin etc. Une attention particulière est accordée aux hommes de lettres qui tentent de concilier un travail de plume mal considéré avec leurs ambitions littéraires. Les pratiques des traducteurs sont enfin cernées par l’analyse des textes et de leur « mise en livre », en comparant différentes traductions (concurrentes ou successives) d’un même texte. Les motivations diverses de ces versions et la spécificité de chaque projet d’écriture et de publication sont ainsi cernées. Portant sur un large pan de la production écrite en français souvent délaissé par l'histoire littéraire, ce travail sur la pénétration de la culture espagnole en France et sur le monde des traducteurs interroge aussi la relation entre écriture et publication, et sur le rôle de « l’éditorial » dans la construction de l’autorité littéraire
The literary influence exercised by Golden Age Spain on France in the first half of the 17th century is related to a very considerable mass of editorial activity. This thesis, which combines the history of the book and literary history, studies French translations of Spanish texts which circulated in France between 1600 and 1660 - translations concerning texts of all kinds (religious, literary, scientific, technical, etc.).In order to evaluate this editorial activity, a bibliometric enquiry must first be carried out. This enquiry allows us to reconstitute the history of of the circulation of this material in print. The principal centres of production are identified and the production of the workshops of the booksellers’ operating in this market are examined. The analysis then shifts to the activity of translation itself, in all its diversity. The profiles of the different principal translators from Spanish to French are laid out: the professional translator, the enlightened amateur, the printer, the cleric, the physician, etc. Particular attention is paid to men of letters who attempt to conciliate what is perceived as lowly hackwork with their literary ambitions. Finally, the translators’ practices themselves are the object of study, through comparison, using textual analysis as well as examining questions of format and layout, of different (concurrent or successive) translations of the same text. Account is thus made of the diverse motivations of these versions and the specificity of each writing project and publication. Taking as its base a large swathe of writing produced in French often neglected by literary history, this study of the penetration of Spanish culture in France and of the world of translators looks anew at the relation between writing and publication, as well as at the editorial role in the construction of literary legitimacy

Nous avons pour objectif d’établir un modèle de la communication textuelle distinct du modèle de la communication orale. Pour ce faire, il convient d’abord d’illustrer la valeur du texte en tant qu’énoncé en linguistique, à travers une comparaison avec le terme de « discours ». Etant donné que les interlocuteurs ne peuvent se situer dans une simultanéité spatio-temporelle, il est nécessaire d’examiner les facteurs relatifs aux communications textuelles, par exemple, les relations existant entre le texte et les sujets (auteur et lecteurs), la question du temps, etc. Pour établir ce modèle de la communication textuelle, d’une part, nous avons fait appel à la triple mimèsis de Paul Ricœur. D’autre part, nous soulignons la pluralité de l’interprétation. Les différentes interprétations d’un texte ne se produisent pas isolément mais entretiennent des relations interactives. De plus, à travers ces relations, les interprétations forment synchroniquement un plan topographique. Celui-ci n’est pas figé mais se transforme diachroniquement. Nous pouvons définir ces interactions textuelles comme la circulation textuelle. Grâce à cette circulation, un texte peut maintenir sa vitalité, à savoir sa présence
We have objective to establish the model of the textual communication distinct from the model of the oral communication. With this intention, it is initially advisable to illustrate the value of the text as a statement in linguistics, through the comparison with the term "speech". Because the interlocutors cannot be located in space-time simultaneity, it is necessary to examine the factors relating to the textual communication, for example, the relations existing between the text and the subjects (author and readers), the question of time, etc. To establish the model of the textual communication, on the one hand, we count on triple mimèsis of Paul Ricœur. In addition, we underline the plurality of interpretation. Various interpretations of a text do not exist separately but they maintain the interactive relations. Furthermore, through these relations, the interpretations shape synchronically a topographic plan. This one is not fixed but transformed diachronically. We can define these textual interactions as textual circulation. By this circulation, a text can maintain its vitality, namely its presence

L’objectif de cette thèse est de faire découvrir le personnage d’Ahmad al-Rabbât al-Halabî, un libraire syrien qui a vécu entre la seconde moitié du XVIIIe siècle et la première moitié du XIXe siècle, de répertorier et présenter ses manuscrits et d’enquêter sur les utilisateurs « lecteurs » de cette archive culturelle : ce qui peut permettre d’apporter des réponses concrètes à certaines questions sur la littérature arabe, la création et la circulation des textes. Les recherches ont conduit à identifier environ 240 volumes, dispersés un peu partout dans le monde, de la bibliothèque initiale d’al-Rabbât. Les marges de ces manuscrits contiennent un grand nombre de certificats de lecture rédigés par plusieurs générations de lecteurs. Le travail sur les sources manuscrites a aussi donné la possibilité de créer une base de données sur les copistes, les propriétaires et les lecteurs des manuscrits, de déterminer le rôle qu’ont joué les voyageurs occidentaux et les agents consulaires dans la vie de ces documents
The aim of this thesis is to bring to light the unknown figure of Ahmad al-Rabbât al-Halabî, a Syrian bookseller, who lived between the second half of the eighteenth century and the first half of the nineteenth century, to catalog and present his manuscripts and to investigate the users « readers » of this cultural archive: it can provide concrete answers to questions raised in the Arabic literature, the creation and circulation of texts. The research led to identify about 240 volumes, scattered around the world, from the initial library of al-Rabbât. The margins of these manuscripts contain a large number of reading certificates written by many generations of readers.The work on the manuscript sources also presented an opportunity to create a database of the copyists, the owners and the readers of manuscripts, and to determine the role played by Western travelers and consular agents in the production and the history of the manuscripts

La thèse doctorale que j’ai rédigée est entièrement consacrée à l’étude de la Cena Cypriani, un récit facétieux et étrange, qui proposait, sous la forme d’un repas auquel sont conviés les principaux personnages bibliques (d’Adam à Jésus Christ), une singulière parodie de la Bible. La première partie de ma thèse doctorale est entièrement consacrée au texte original ; j’y propose une étude des manuscrits qui transmettent la Cena Cypriani, ainsi que les études critiques de ces témoins réalisées dans le but de proposer une nouvelle édition du texte qui est présentée aux pages 364-402. Ensuite, je me suis intéressé à l’étude littéraire, linguistique et sociologique du texte : j’ai, en effet, montré que la Cena est un exercice littéraire d’une extraordinaire complexité. Lors de mes recherches je me suis demandé quelle était la fonction des modèles littéraires de la Cena, comme par exemple le Iudicium coci et Pistoris et le Testamentum porcelli, et je suis arrivé à l’hypothèse que la Cena était, au Ve siècle, un texte écrit pour le divertissement érudit des élites, et qu’il était probablement lu lors d’un banquet de cour. Dans la seconde partie du texte, j’ai cherché à comprendre la raison de la circulation de la Cena au Moyen Âge. Ses réélaboration du Haut Moyen Age - la Cena Hrabani et la Cena Iohannis, ont été des instruments précieux pour mes recherches puisqu’elles m’ont permis de remarquer la continuité textuelle et culturelle qui lie l’œuvre de Raban Maur à celle d’lnmonidés ; elles m’ont également été utiles pour comprendre la fonction didactique et religieuse de la Cena et pour justifier la raison de sa circulation médiévale
My doctoral thesis is entirely dedicated to the study of the Cena Cypriani, a bizarre and comic text that proposes a strange biblical parody, depicted as a biblical banquet. The first part of my doctoral thesis is completely dedicated to the original text, wherein I study the tradition of the manuscripts of the Cena and where I propose some critical studies of its codices in order to provide a new critical edition of the text (see pages 364-402). Following this, l propose some literary, linguistic and sociologie studies of the text by demonstrating that the Cena Cypriani was a very complex literary exercise. During my research, I had the possibility of posing the question about the Cena’s literary sources, as for example, the Iudicium Ceci et Pistoris and the Testamentum Porcelli. Through this, l was able to elaborate the hypothesis that the Cena took place during the Vth century, written to entertain the elites, most likely during banquets. In the second part of my thesis, I tried to understand the reason of the Cena's circulation during the Middle Ages. The Early Medieval re-writing of the Cena Cypriani - the Cena Hrabani and the Cena Nuptialis - represents very important instruments for my research because they allow me to understand the continuity between the two texts ; they were very useful to understand the didactic and religious function of the Cena and to justify its medieval transmission and importance

Eighteen healthy dogs were divided into three equal groups. All dogs were evaluated at the beginning of the experiment with complete physical examination, complete blood count, serum alanine aminotransferase, serum alkaline phosphatase, serum bilirubin, serum albumin, sulfobromophthalein. excretion test, ammonia tolerance test, glucagon response test, portal and intraparenchymal pressures, operative mesenteric portography, and histologic assessment of hepatic tissue. The left hepatic vein was ligated in the chronic and acute dogs. The dogs had a ligature placed loosely around the left hepatic vein. Acute and control dogs were evaluated 24 hours postoperatively with the hematologic and biochemical tests listed above. Acute dogs were evaluated with portal and intraparenchymal pressure, operative mesenteric portography and histologic evaluation of hepatic tissue at 48 hours postoperatively. Chronic and control dogs were evaluated at 4 weeks postoperatively with all of the tests listed above. The results of all tests performed supported a transient hepatic congestion which resolved bv the fourth postoperative week. No longstanding effect on hepatic function was found. The conclusion of this experiment was that, in normal dogs, left hepatic vein ligation does not cause severe or permanent liver damage. These findings support a clinical trial of this procedure in patients with patent ductus venosus.
Master of Science

Nous considérons les écoulements monophasiques de fluide faiblement compressible en milieux poreux fracturé, avec application à l'interprétation des essais de puits. Nous avons suivi l'approche de mise à l'échelle par Prise de Moyenne Volumique de Quintard et Whitaker en laquelle le problème est remplacé par un modèle macroscopique continu de type double porosité. Les descriptions locales et macroscopiques sont reliées par la résolution de problèmes de fermeture permettant de déterminer explicitement les propriétés de transports macroscopiques à partir d'une cellule représentative du milieu fracturé étudié. A l'aide de méthodes numériques adaptées, nous avons mené une étude des coefficients paramétrant ce modèle macroscopique, pour des géométries de fractures réalistes. Nous avons ainsi mis en évidence le rôle important que pouvait jouer la perméabilité de la matrice au voisinage du seuil de percolation. Nous nous sommes focalisé sur l'étude du terme d'échange matrice-fracture, qui est un paramètre controversé dans la littérature. Par utilisation de la méthode de Fourier, nous avons pu identifier la plupart des méthodes de calcul de ce coefficient dans un même cadre permettant des comparaisons aisées. Dans une deuxième partie, nous avons abordé la question de l'applicabilité des approches macroscopiques développées aux simulations des essais de puits. Nous avons d'abord développé une méthodologie de résolution de ce problème à l'échelle locale. Nous avons notamment montré les limites des techniques numériques standard à simuler les essais de puits, lorsque les rapports d'aspect des mailles fracture/matrice étaient très important. En utilisant des maillages très raffinés, on montre toutefois un bon accord entre les simulations fines et le modèle macroscopique, améliorés en prenant en compte une description transitoire des échanges.

Thesis (MSc (Biomedical Sciences))--Cape Peninsula University of Technology, 2018.
Background: Early detection of individuals who are at risk of developing Glucose Intolerance would decrease the morbidity and mortality associated with this disease. MicroRNA is one of the most widely studied biomolecules involved in epigenetic mechanisms, hence it offers unique opportunities in this regard. Circulating microRNAs are associated with disease pathogenesis during the asymptomatic stage of disease. This has therefore attracted a lot of attention as a potential biomarker for identifying individuals who have an increased risk of developing Glucose Intolerance. The identification of high risk biomarkers for Glucose Intolerance will go a long way to eliminate the possible complications that arise due to late diagnosis and treatment of Glucose Intolerance. This could ultimately lead to better ways to prevent, manage and control the Glucose Intolerance epidemic that is rampant worldwide. The aim of the study is to investigate expression of circulating microRNA’s in blood of mixed ancestry subjects with glucose intolerance. Methods: A quantitative cross-sectional study design involving 36 individuals [who were age, gender and BMI (Body Mass Index) matched] from a total population of 1989 participants of mixed ancestry descent, residing in Bellville South, South Africa was used. Participants were classified as controls (normoglycemic), pre-diabetic (preDM) and diabetic (DM) (screen detected diabetic) according to WHO criteria of 1998. MicroRNAs were extracted from serum using the Qiagen miRNeasy Serum/Plasma Kit (ThermoFisher). The purified micro RNAs were reverse-transcribed to cDNA (complementary deoxyribonucleic acid) using the Qiagen RT2 First Strand Kit. Then, using Qiagen miScript SYBR Green PCR kit and miScript miRNA PCR arrays (ThermoFisher), the real time polymerase chain reaction was done to determine the expression profile the circulating micro RNAs present in the serum of the participants. Results: The 36 participants were evenly divided into 3 groups of 12 participants each as mentioned earlier. There were significant differences between groups in the waist (cm) (p=0.0415) and waist/hip ratio (p=0.0011) with highest values in the DM group and lowest in the normal group. Clinical parameters varied significantly according to glycemic status. As expected, the FBG (mmol/L) (p<0.0001), 2 HRs Post Glucose (mmol/L) (p<0.0001), HbA1c (%) (p=0.0009), Fasting Insulin (mIU/L) (p=0.0039), were all highest in the DM and lowest in the control group. In contrast, the 2 HRs Post Insulin (mIU/L) (p = 0.0027) was highest in the preDM group and lowest in the normal group, while the Glucose/Insulin ratio (p=0.0477) was highest in the normal group and lowest in the preDM group. Triglycerides (mmol/L) (p=0.0043) and Total Chol (mmol/L) (p=0.0429) were significantly increased through the three groups, with highest values in the DM group and lowest in the normal group. Furthermore, 12 of the 84 miRNAs studied were expressed through all the 3 groups and they exhibited both inverse and positive correlations between the clinical parameters, especially the glucose parameters (Fasting blood glucose, 2 hours post glucose, Fasting blood insulin, 2 hours post insulin and Glycated Hemoglobin).

L’objectif de cette thèse est de déterminer comment le modèle de continuum sol plante atmosphère, développé par l’INRA (Tuzet et 2003), très sensible au stress hydrique, peut être incorporé à un modèle de circulation générale (GCM) et s’il peut lui apporter une amélioration sensible. Un schéma de résolution numérique a été créé, adapté à la logique de résolution des GCM tout en conservant les interactions responsables de l’équilibre du continuum. Cette résolution améliore ses performances (temps de calcul, stabilité). Les résultats de ce modèle ont été comparés avec ceux de SECHIBA (le GCM du LMD) et plus sommairement d’autres modèles sur un site semi-aride en Arizona, en marge d’une campagne de PILPS (Bastidas 2003). Son comportement est globalement meilleur mais insuffisamment pour justifier son insertion dans un GCM. L’évaporation du sol limite les performances des modèles, en raison d’un bilan hydrique trop simple pour l’INRA, et d’erreurs de résolution numériques dans SECHIBA.

Experimental methods for the investigation of trailing vortex strengths, total lift, and lift distributions for three-dimensional wings in close proximity flight were developed. With these experiments we model compound aircraft flight either docked tip-to-tip, or flying in formation. There is a distinct lack of experimental formation flight data using three-dimensional wing models for tests. The absence of fixed walls on either end of the wing permits the development of the asymmetric shedding of vortices, and the determination of the asymmetric circulation distribution induced by the proximity of the leading wing. The pair consisted of a swept NACA-0012 non-cambered wing simulating one half of a leading aircraft and a rectangular cambered NACA 63-420 wing simulating the trailing aircraft. Important aspects of the work included theoretical development, experimental setup, data acquisition and processing, and results validation. Experimentally determining the lift for formation flight, in addition to the local flow behavior for a pair of wings, can provide valuable insight for the proposition of flying actual aircraft in formation to increase mission efficiency. To eliminate the need for bulky mounting stings and direct load measurement devices that can potentially interfere with the local flowfield, a minimally invasive velocity probe method is developed. A series of experiments were performed to assist with the development of the method. Velocity and vorticity distributions obtained along a near-field plane were processed to calculate wingtip vortex strengths. Additionally, vortex position instabilities and the shedding of vorticity inboard of the wingtips were observed. To determine the circulation distributions for the trailing wing, the initial method is modified. By processing velocity information acquired in a near-field plane, both the lift and induced drag were calculated for the trailing airfoil. Comparisons are made to directly measured loads and to results reported earlier. Directly measured lift and drag coefficients were found to agree with existing literature.
Master of Science

The effects of moderate workload exercise at different pedal rates on circulatory and respiratory parameters were studied. Five subjects performed seven discontinuous constant-load cycle ergometer tests of 30 minutes duration at pedal rates of 40, 50, 60, 70, 80, 90 and 100 rpm. Oxygen uptake and carbon dioxide production were determined by standard open circuit spirometry, while heart rate was recorded by electrocardiograph. The CO₂ rebreathing procedure was administered during the exercise bout in order to determine cardiac output. Blood pressure was determined for each test, and total peripheral resistance was calculated. The findings indicate that progressive increases in pedal frequency during discontinuous constant-load cycle ergometry produce progressive increases in cardiovascular, respiratory and metabolic responses and a decrease in gross exercise mechanical efficiency. The results indicate that oxygen uptake, cardiac output, heart rate, ventilation and arterial-venous oxygen difference increases curvilinearly as pedal rate increases, possibly as a result of increases in recruitment of muscle fibers and/or muscle groups. These findings suggest that circulatory and respiratory responses are due to "central command" which sets the basic efferent response pattern. However, this effector pattern is modulated by afferent input originating from the legs during progressive increases in pedal rate.

Le canal sodique Nav1.5, codé par le gène Scn5a, est nécessaire au potentiel d’action des cardiomyocytes. Mais son expression a aussi été décrite dans divers contextes et a été associée à de nouvelles fonctions. Une expression a été montrée dans le muscle lisse des voies respiratoires, suggérant une implication de Nav1.5 dans la fonction respiratoire. Ce travail a consisté à décrire les expressions et à montrer les rôles potentiels de Nav1.5 dans la respiration chez la souris. Des analyses histologiques ont confirmé l’expression de Nav1.5 dans le muscle lisse des voies respiratoires in situ, mais un site d’expression majeur a également été montré à la membrane plasmique de « cardiomyocytes » présents dans les veines pulmonaires. Des tests de contractilité des voies respiratoires ont été réalisés sur des souris knock-out Scn5a+/-. Ils ont montré ex vivo par des tests de contractilité de trachées isolées une baisse de la contraction pour les souris femelles Scn5a+/- , et WT pré-incubées à l’ajmaline ou à la kétamine, des inhibiteurs sodiques. Cet effet a été confirmé in vivo par pléthysmographie corporelle totale montrant une hyporéactivité respiratoire chez les souris Scn5a+/- femelles. Aucun remodelage structural ou inflammatoire n’y étant associé, cela suggère un rôle électrique de Nav1.5 dans la respiration. Les souris Scn5a+/- mâles n’ont pas montré de diminution d’expression et de fonction pour Nav1.5, suggérant une possible influence hormonale dans sa régulation. Pour conclure, Nav1.5 contribue à la contractilité des voies respiratoires chez la souris. Il reste à déterminer ses mécanismes d’action et ses éventuelles implications en pathologie, notamment dans l’asthme
Nav1.5 sodium channel, encoded by the Scn5a gene, is necessary for action potential in cardiomyocytes. However, its expression has been described in various contexts and has been associated with new functions. An expression has been recorded in airway smooth muscle, suggesting an involvement of Nav1.5 in respiratory function. The aim of the work has been to describe the expressions and to highlight the potential roles of Nav1.5 in mice breathing. Histological assay has confirmed Nav1.5 expression in airway smooth muscle in situ, but a major expression site has been showed at the plasma membrane of “cardiomyocytes” located in pulmonary veins. Airway contractility assessments were made on knock-out Scn5a+/- mice. Ex vivo isolated trachea contractility test showed a decrease of contraction for Scn5a+/- mice and for WT mice pre-incubated with sodium blockers ajmaline or ketamine.This effect was confirmed by in vivo whole body plethysmography, showing respiratory hyporesponsiveness on female Scn5a+/- mice. No structural of inflammatory remodelings were associated, suggesting an electrical role for Nav1.5 in respiration. Male Scn5a+/- mice do not showed a significant decrease of Nav1.5 expression, suggesting a possible hormonal influence in its regulation. To conclude, Nav1.5 contribute to mice airway contractility. It remains to determine its mechanism of action and its potential involvement in pathological context such as asthma

O presente trabalho teve por finalidade estudar as alterações do sistema circulatório provocadas pela cirurgia cardíaca sob circulação extracorpórea, 12 pacientes adultos, anestesiados e curarizados, selecionados aleatoriamente, sendo 6 deles valvopatas e 6 coronariopatas. As alterações respiratórias foram verificadas por medidas da mecânica respiratória e da ventilação-oxigenação pulmonar. Do ponto de vista mecânico, o sistema respiratório foi analisado como um todo e individualizando os seus componentes - pulmões e parede torácica, tanto do ponto de vista elástico como também fluxo-resistivo. A análise das propriedades resistivas do sistema respiratório foi feita através de um método que se utiliza da insuflação pulmonar com fluxo constante, seguida de uma oclusão súbita das vias aéreas. Esta análise permite que tanto para o sistema respiratório como também para os pulmões e parede torácica, obtenha-se o valor resistivo máximo (Rmax) bem como o valor mínimo da resistência (Rmin) ao lado das resistências geradas pelas desigualdades do sistema (Ru). Este estudo foi feito graças a estimativa das diferentes respostas de frequência de cada um destes componentes. As medidas de ventilação-oxigenação foram aferidas pelo cálculo do \"shunt\" pulmonar (Qs/Q) e gradiente alvéolo-arterial de oxigenio P(A-a)O2. Tanto as medidas mecânicas como as de ventilação-oxigenação foram feitas na vigência de uma fração inspirada de O2 de 100% e realizadas de 15 a 30 minutos após a entubação traqueal, sendo repetidas logo após o fechamento do tórax. [...]
The aim of this work was to study the respiratory alterations caused by cardiac surgery under cardiopulmonary bypass in 12 randomly selected anesthetized paralyzed adult patients; 6 with acquired valvar disease and 6 with ischmic cardiopathy. Respiratory alterations were assessed by respiratory mechanics and lung ventilation-oxygenation measurements. Respiratory mechanics analyzed the respiratory system as a whole and partitioned into its components: lung and chest wall, measuring both the elastic and resistive properties were measured using a constant inflation flow followed bu a sudden occlusion. This analysis provides the maximum resistance value (Rmax), the minimum resistance value (Rmin), and the resistance caused by the uneven distribution of mechanical properties within the system (Ru), for respiratory system, lung and chest wall. This analysis is based on the frequency dependence differences of each component of respiratory system. The ventilation-oxygenation evaluation was done by the calculation of pulmonary shunt and the alveolar arterial oxygen gradient (P (A-a)O2). Both mechanical and ventilation-oxygenation measurement were done with a oxygen inspired fraction of 1 and performed 15 to 30 minutes after tracheal intubation and repeated just after thorax closure. [...]

Orientadores: Desanka Dragosavac, Luis Alberto Magna
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Introdução: A operação cardíaca com utilização da circulação extracorpórea (CEC) está associada ao desenvolvimento da resposta inflamatória sistêmica e, como conseqüência, à disfunção pulmonar. O uso de ultrafiltração no intra-operatório tem sido proposto para remoção dos mediadores inflamatórios liberados durante a CEC, na tentativa de minimizar a resposta inflamatória. Objetivo: Avaliar o efeito da ultrafiltração nos níveis séricos de interleucinas, fator de necrose tumoral-alfa e na função pulmonar de pacientes submetidos à revascularização do miocárdio. Método: Foi realizado um estudo clínico, prospectivo, randomizado, com 40 pacientes, divididos em dois grupos, em um hospital terciário. Um grupo foi submetido à ultrafiltração (UF) durante a CEC e outro grupo (controle), não. Foram mensurados interleucinas (IL-ip, IL-6, IL-8), fator de necrose tumoral alfa (TNF-a), índices de troca gasosa pulmonar [PaO2/FiO2, D(A-a)O2 e VD/VT] e mecânica ventilatória (Cst e Raw) nos períodos pré-operatório, intra-operatório e dois dias de pós-operatório. As interleucinas e TNF-a foram analisadas também no perfusato, no grupo teste. Resultados: Houve aumento de IL-ip (30 minutos após a CEC e 12 horas após a operação) e IL-6 (24 e 36 horas após a operação) no grupo UF comparado ao grupo controle. Houve aumento de IL-6 em todos os tempos comparados ao tempo inicial, em ambos os grupos. Foi observada diminuição da IL-8 cinco minutos antes da CEC e aumento seis, i2, 24, e 36 horas após operação, além de aumento de TNF-a nos tempos 30 minutos após CEC, 24, 36 e 48 horas após operação. Na análise do líquido ultrafiltrado foi identificada a presença de TNF-a e das demais IL-ip, IL-6, IL-8, somente em traços. Na função pulmonar, houve piora da PaO2/FiO2, D(A-a)O2, VD/VT, cinco minutos antes da CEC, além da diminuição da D(A-a)O2 30 minutos após CEC, seis,i2, 24 e 36 horas após operação. Houve aumento da complacência estática pulmonar (Cst) e queda da resistência de vias aéreas (Raw) cinco minutos antes da CEC, além da queda da Raw seis horas após a operação nos dois grupos. Conclusão: A utilização de ultrafiltração aumentou o nível sérico das IL-i e IL-6, não interferindo na troca gasosa e na mecânica pulmonar de pacientes submetidos à revascularização do miocárdio
Abstract: Introduction: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with the development of systemic inflammatory response and, in consequence, pulmonary dysfunction. The use of ultrafiltration intraoperatively has been proposed to remove inflammatory mediators released during CPB in an attempt to minimize the inflammatory response. Objective: Evaluating the effect of ultrafiltration on the serum levels of interleukin, tumor necrosis factor alpha and pulmonary function in patients undergoing myocardial revascularization. Methods: It was carried out a prospective randomized clinical trial on 40 patients divided into two groups, in a tertiary hospital. One group was submitted to ultrafiltration (UF) during CPB whereas the other group (control), was not. It were mensured interleukins (IL-ip, IL-6, IL-8), tumor necrosis factor alpha (TNF-a), pulmonary gas exchange indexes [PaO2/FiO2, D(A-a)O2 and VD/VT] as well as respiratory mechanics (Cst e Raw) in the preoperative and intraoperative periods and postoperatively. The interleukins and TNF-a were also analyzed in the perfusate in the test group. Results: There was an increase in IL-ip (30 minutes after CPB and 12 hours after surgery) and in IL-6 (24 and 36 hours after surgery) in the UF group by comparison with the control one. There was also an increase in IL-6 at all schedulled times compared to the initial period in both groups. It was noticed a decrease in IL-8 five minutes before CPB and an increase six, i2, 24 and 36 hours after surgery in addition to an increase in TNF- a at the times 30 minutes after CPB, 24, 36 and 48 hours after surgery. On analyzing the ultrafiltrated fluid it was identified the presence of TNF-a and the other IL-ip, IL-6, IL-8 only in traces. Regarding pulmonary function, there was a worsening of PaO2/FiO2, D(A-a)O2, and VD/VT five minutes prior to CPB in addition to a decrease in D(A-a)O2 30 minutes after CPB, six, 12, 24 and 36 hours after surgery. There was an increase in the pulmonary static compliance, and a fall of the airway resistance five minutes before CPB. Also, there was a fall of the airway resistance six hours after surgery in both groups. Conclusion: The use of ultrafiltration has increased the serum levels of IL-1 and IL-6 without interfering with the pulmonary gas exchange and respiratory mechanics in patients undergoing myocardial revascularization
Doutorado
Pesquisa Experimental
Doutor em Cirurgia

Le sepsis est la 3eme cause de mortalité dans les pays occidentaux, avec un taux de mortalité entre 20 et 50% selon la sévérité. La « prédiction » du devenir clinique du patient est essentielle pour établir le traitement le plus adéquat. Quelques protéines marqueurs de l'inflammation ou d'une infection (CRP, procalcitonine) sont citées pour le suivi des patients en clinique mais manquent de spécificité pour le sepsis. D'autre part, les études « omiques » ont permis de générer des listes de biomarqueurs potentiels du pronostic vital du sepsis. En revanche, aucun n'a encore été validé et/ou confirmé en fonction de la gravité du sepsis et du devenir du patient. Il faut pour cela accéder non seulement à des cohortes de patients parfaitement caractérisées et également disposer de méthodes quantitatives robustes et validées. La spectrométrie de masse apporte une capacité de spécificité et de multiplexage à haut niveau qui permettait de confirmer l'intérêt d'une ou plusieurs de ces protéines dans le cas du pronostic du sepsis. Les dosages immunologiques apportent quant à eux en plus de la sensibilité et de la spécificité, une mise en œuvre en routine clinique simple et rapide. Dans un premier temps, une liste de biomarqueurs identifiés avec des cohortes de patients a été établie d’après la littérature. Puis, des méthodes de quantification de ces biomarqueurs ont été développées. Nous nous sommes intéressés d’une part à quantifier les calgranulines dans le plasma en développant des ELISA et des méthodes de spectrométrie de masse par des approches bottom-up et top-down. D’autre part, deux méthodes de quantification multiplexes ont été développées par spectrométrie de masse avec et sans étape d’immunopurification en fonction des concentrations des protéines présentes dans le plasma afin de vérifier la pertinence de la liste de biomarqueurs potentiels. Toutes ces méthodes ont été appliquées à une cohorte de 49 patients atteints de choc septique
Sepsis is the 3rd leading cause of death in Western countries, with a mortality rate between 20 and 50% depending on the severity. The 'prediction' of the patient's clinical outcome is essential to establish the most appropriate treatment. Some inflammation or infection markers protein (CRP, procalcitonin) are cited for clinical follow-up of patients but lack specificity for sepsis. On the other hand, "omics" studies have generated lists of potential biomarkers of sepsis prognosis. However, none have yet been validated and/or confirmed based on the severity of the sepsis and the patient's fate. This requires access not only to fully characterized patient cohorts but also to robust and validated quantitative methods. Mass spectrometry provides a high level of specificity and high multiplex capacity and that would allow to confirm the interest of one or more of these proteins for sepsis prognosis. Immunological assays provide, in addition to sensitivity and specificity, a simple and rapid routine clinical implementation. First, a list of biomarkers identified with patient cohorts was established from the literature. Then, methods to quantify these candidate biomarkers were developed. On the one hand, we have been interested in quantifying calgranulins in plasma by developing ELISAs and mass spectrometry methods using bottom-up and top-down approaches. On the other hand, two multiplex quantification methods by mass spectrometry with and without immunopurification step according to protein concentrations have been developed to verify the relevance of the list of potential biomarkers. All these methods were applied to a cohort of 49 patients with septic shock

UVOD: Hipertenzivna oboljenja u trudnoći predstavljaju heterogenu grupu bolesti koja se javljaju kod 3-8% trudnica opšte populacije. Najteže forme ovih oboljenja preeklampsija, eklampsija i HELLP sindrom su vodeći uzročnici morbiditeta i mortaliteta majke i ploda u odnosu na sve druge komplikacije u trudnoći. Etiopatogeneza ovih oboljenja je još uvek nedovoljno razjašnjena ali se smatra da placenta ima ključnu ulogu u nastanku ovih komplikacija, odnosno da placentalna insuficijencija, koja nastaje kao posledica nedovoljne adaptacije decidualnih i intramiometrijalnih delova spiralnih arterija već u prvih nekoliko nedelja trudnoće, dovodi do redukcije utero-placentalne cirkulacije i lokalne placentalne hipoksije, što se nepovoljno održava i na majku i na plod. U cilju razjašnjenja patofizioloških mehanizama nastanka hipertenzivnih oboljenja u trudnoći i pronalaska dovoljno senzitivnih makera koji bi pomogli u ranom predviđanju nastanka najtežih formi ovih oboljenja, do sada su ispitivani brojni proteini koji učestvuju u procesima stvaranja i razvoja placentalne vaskularne mreže kao što su vaskularni endotelni faktor rasta (VEGF-A), placentalni faktor rasta (PlGF) i solubilni receptor fms-like tirozin kinaza receptor (sFlt-1). CILJ: Uporediti serumske koncentracije (sFlt-1, PlGF, VEGF-A, PAPP-a, freeßhCG, glukoze, ukupnog holesterola, HDL holesterola, LDL holesterola, triglicerida, apo-AI, apoB, AST, ALT, GGT, kreatinina, ureje, mokraćne kiseline, hsCRP, Na, K, Cl, P, Mg i Ca između grupe trudnica sa preeklampsijom, hroničnom i gestacijskom hipertenzijom i kontrolne grupe trudnica u prvom trimestru trudnoće između 11 i 14. nedelje gestacije. Ispitati da li se vrednosti odabranih laboratorijskih parametara (sFlt-1, VEGF-A i PLGF) kod ispitivanih trudnica statistički značajno razlikuju u odnosu na gestacijsku nedelju u trenutku porođaja, težinu i dužinu i APGAR skor bodovanja novorođenčeta. Ispitati da li se vrednosti angiogenih proteina:sFlt-1, VEGF-A, PlGF značajno razlikuju kod ispitivanih trudnica u odnosu na broj prethodnih trudnoća i starosti trudnica. MATERIJAL I METODE: Istraživanje je sprovedeno kao prospektivno analitička studija u Kliničkom centru Vojvodine, u periodu od juna 2012. do februara 2015. godine. U istraživanje je uključeno ukupno 143 trudnice starosti od 18 – 43 godine. Sve trudnice uključene u istraživanje podeljene su na dve ispitivane i jednu kontrolnu grupu. Prvu ispitivanu grupu činilo je 43 trudnice koje su po definisanim kriterijuma razvile preeklampsiju u aktuelnoj trudnoći. Drugu ispitivanu grupu činilo je 46 trudnica kojima je dijagnostikovana ili potvrđena hronična ili gestacijska hipertenzija u aktuelnoj trudnoći. Kontrolnu grupu činilo je 54 zdravih trudnica sa verifikovanim fiziološkim ishodom trudnoće u terminu, bez maternalnih i fetalnih komplikacija. Prilikom regrutovanja trudnica (između 11+0 i 13+6 nedelja gestacije) za učešće u istraživanju, uzeti su anamnestički podaci o faktorima rizika za pojavu hipertenzivnih oboljenja u trudnoći, i u okviru kliničkog i akušerskog pregleda urađena su antropometrijska merenja, merenje krvnog pritiska, i specijalizovani ultrazvučni pregled ploda radi utvrđivanja gestacijske starosti ploda i određivanja rizika za pojavu hromozomskih anomalija ploda. Trudnicama je nakon uzimanja anamnestičkih podataka i kliničkog i akušerskog pregleda i potpisanog pisanog pristanka pacijenta o dobrovoljnom učestvovanju u istraživanju izvađena krv radi određivanja odabranih laboratorijskih parametara. Serumske koncentracije sFlt1, VEGF-A i PIGF određivane su kvantitativnom ELISA tehnikom (R&D Systems Europe Ltd. Abingdon, UK), dok su: glukoza, ukupni holesterol, HDL holesterol, LDL holesterol, trigliceridi, apo-AI I apoB, AST, ALT, GGT, kreatinin, ureja, mokraćna kiselina, hsCRP, Na, K, Cl, Mg, P, Ca određivani na automatizovanim analizatorskim sistemima. Sve trudnice su kategorisane u 2 ispitivane i kontrolnu grupu na osnovu pojave ili isključenja hipertenzivnih oboljenja u aktuelnoj trudnoći. Statistička obrada podataka urađena je u statističkom programu STATISTICA 12 (StatSoft Inc.,Tulsa, OK, USA). Podaci su predstavljeni tabelarno i grafički, nivo statističe značajnosti p, je tumačen statistički značajnim ukoliko su vrednosti p<0,05. REZULTATI: Vrednosti serumskih koncentracija sFlt-1 se statistički značajno razlikuju u sve tri grupe ispitanica i značajno su više u grupama sa hipertenzivnim oboljenjima u odnosu na zdravu grupu ispitanica, p<0,001. Serumske koncentracije VEGF-A su značajno niže u grupi trudnica sa preeklampsijom u odnosu na zdrave trudnice kontrolne grupe (p<0,001), dok se nivoi serumskih koncentracija PlGF statistički značajno razlikuju između sve tri grupe trudnica tako da su najniže vrednosti uočene u grupi sa preeklampsijom (p<0,001) u odnosu na preostale dve grupe ispitanica. Nije uočeno postojanje statistički značajne razlike u nivoima PAPP-A, biohemijskih parametara (glukoze, AST, ALT, GGT kreatinina, ureje, mokraćne kiseline), lipidskih parametara (uk. holesterol, LDL, apo A-I, apo B), parametara inflamatornog (kompletna krvna slika, fibrinogen), hemostaznog (D-dimer, vWF-antigen) i elektrolitskog statusa (Na, K, Cl, P, Mg), p>0,05. Nivoi free ßhCG i HDL holesterola su značajno niže, dok su vrednosti hsCRP i triglicerida značajno više u grupi trudnica sa preeklampsijom u odnosu na grupu bez hipertenzivnih poremećaja u trudnoći. Serumske koncentracije sFlt-1 preko 865 pg/ml imaju senzitivnost od 93% i specifičnost od 81,5% u predviđanju nastanka preeklampsije, dok serumske koncentracije PlGF ispod 60 pg/ml senzitivnost od 88,4% i specifičnost od 79,6% u predviđanju pojave preeklampsije. Serumske koncentracije sFlt-1, VEGF-A i PlGF ne pokazuju statistički značajnu razliku u odnosu na godine života trudnice i broja prethodnih trudnoća p>0,05. Serumske koncentracije sFlt-1 i PlGF se značajno razlikuju u odnosu na telesnu težinu novorođenčeta, tako da su niže vrednosti oba proteina detektovane u grupi novorođenčadi sa porođajnom težinom ispod 1500 gr. u odnosu na telesnu masu između 2800-3300 gr, p<0,001. Takođe su nađene niže vrednosti sFlt-1 i PlGF u grupi trudnica koje su se porodile pre 33. nedelje gestacije u odnosu na nedelju gestacije u trenutku porođaja preko 37 nedelje gestacije, p<0,001. Serumske koncentracije sFlt-1 i PlGF se značajno razlikuju u odnosu na indeks telesne mase majke tako da su više vrednosti sFlt-1 i niže vednosti PlGF nađene u grupi trudnica sa indeksom telesne mase ispod 25 u odnosu na grupu trudnica sa indeksom telesne mase preko 30 kg/m2, p<0,001. Serumske koncentracije sFlt-1 u prvom trimestru trudnoće su značajno povezane sa parametrima inflamacije (hsCRP), vrednostima dijastolnog krvnog pritiska i nivoima free ßhCG. Takođe se uočava značajna povezanost koncentracije PlGF sa indeksom telesne mase, vrednostima sistolnog krvnog pritiska i koncentracijom hsCRP u prvom trimestru trudnoće. ZAKLJUČAK: Nivoi antiangiogenog proteina sFlt-1 su više u grupi trudnica sa preeklampsijom u odnosu na grupu sa hroničnom i gestacijskom hipertenzijom i grupu trudnica bez hipertenzivnih poremećaja trudnoći. Nivoi proangiogenog proteina VEGF-A su značajno niže u grupi trudnica sa preeklampsijom i hroničnom i gestacijskom hipertenzijom u odnosu na grupu trudnica bez hipertenzivnih poremećaja u trudnoći. Serumske koncentracije proangiogenog proteina PlGF su niže u grupi trudnica sa preeklampsijom u odnosu na grupu sa hroničnom i gestacijskom hipertenzijom i grupu trudnica bez hipertenzivnih poremećaja trudnoći. Serumske koncentracije placentalnog proteina free ßhCG i HDL holesterola su značajno niže, dok su vrednosti hsCRP i triglicerida značajno više u grupi trudnica sa preeklampsijom u odnosu na grupu bez hipertenzivnih poremećaja u trudnoći. Između trudnica sa hipertenzivnim poremećajima u trudnoći i zdravih trudnica nije uočeno postojanje značajne razlike u vrednostima placentalnog proteina PAPP-A, biohemijskih parametara (glukoze, AST, ALT, GGT kreatinina, ureje, mokraćne kiseline), lipidskih parametara (uk. holesterol, LDL, apo A-I, apo B), parametara inflamatornog (kompletna krvna slika, fibrinogen), hemostaznog (D-dimer, vWF-antigen) i elektrolitskog statusa (Na, K, Cl, P, Mg). Serumske koncentracije sFlt-1 i PlGF se značajno razlikuju u odnosu na gestacijsku starost na porođaju i telesnu masu novorođenčeta i niže su kod trudnica koje su se prevremeno porodile kao i kod novorođenčati sa manjom porođajnom težinom. Serumske koncentracije sFlt-1 se značajno razlikuju u odnosu telesnu dužinu i APGAR skor novorođenčeta, tako da su više vrednosti sFlt-1 udružene sa većom telesnom dužinom novorođenčeta i boljim APGAR skorom. Serumske koncentracije sFlt-1, VEGF-A i PlGF se ne razlikuju značajno u odnosu na godine života trudnice i broja prethodnih trudnoća. Nivoi proteina angiogeneze sFlt-1 i PlGF predstavljaju dobre prediktore u predviđanju nastanka preeklampsije u prvom trimestru trudnoće.
INTRODUCTION: Hypertensive disorders in pregnancy are a heterogeneous group of diseases that occur in 3-8% of all pregnancies. The most difficult forms of these diseases: preeclampsia, eclampsia and HELLP syndrome are the leading causes of maternal and fetal morbidity and mortality in relation to all other pregnancy complications. Etiopathogenesis of these diseases is still insufficiently understood but it is thought that the placenta plays a key role in the development of these complications, and that placental insufficiency, which occurs as a result of insufficient adaptation of decidual intramiometrial and parts of the spiral arteries in the first few weeks of pregnancy, leading to a reduction of utero- placental circulation and local placental hypoxia, which adversely affects the mother and the fetus. In order to elucidate the pathophysiological mechanisms of hypertensive disorders in pregnancy and to find sufficiently sensitive makers for early prediction of the most severe forms of these diseases, so far have been investigated a number of proteins involved in the processes of creation and development of placental vascular network such as vascular endothelial growth factor (VEGF-A), placental growth factor (PlGF) and soluble fms-like receptor tyrosine kinase receptor (sFlt-1). OBJECTIVE: The aim of the study was to compare serum concentration of sFlt-1, PlGF, VEGF-A, PAPP-A, freeßhCG, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apo-AI, apo B, AST, ALT, GGT, creatinine, urea, uric acid, hsCRP, Na, K, Cl, P, Mg and Ca between the group of pregnant women with preeclampsia, chronic and gestational hypertension and the control group of pregnant women in the first trimester of pregnancy between 11 and 14 weeks gestation. Also the aim was to examine whether the value of selected laboratory parameters (sFlt-1, VEGF-A and PlGF) differ in relation to gestational week at the time of birth, weight, length and APGAR scoring system of newborns. The aim was to examine whether the value of angiogenic proteins: sFlt-1, VEGF-A and PlGF differ significantly in relation to the number of previous pregnancies and age of the pregnant woman. MATERIALS AND METHODS: The study was conducted as a prospective analytical study in the Clinical Center of Vojvodina, in the period from June 2012 to February 2015. The study included a total of 143 pregnant women aged 18 - 43 years. All pregnant women included in the study were divided into two study and one control group. The first study group consisted of 43 pregnant women who developed preeclampsia during the current pregnancy. The second study group consisted of 46 pregnant women who are newly diagnosed or confirmed chronic or gestational hypertension during the current pregnancy. The control group consisted of 54 healthy pregnant women with verified physiological outcome of pregnancy at term without maternal and fetal complications. Patients were included in the study between 11 + 0 and 13 + 6 weeks of gestation. All patients had data about risk factors for developing hypertensive disorders in pregnancy. After clinical and obstetric examination all patients underwent anthropometric measurements, measurement of blood pressure, and specialized ultrasound examination to determine precise gestational age of the fetus and to determine the risk for fetal chromosomal abnormalities. All patients signed a written consent of the patient's voluntary participation in the study. Serum levels of sFlt1, VEGF-A and PlGF were determined by quantitative ELISA (R & D Systems Europe Ltd., Abingdon, UK), while glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apo-AI, apo B, AST, ALT, GGT, creatinine, urea, uric acid, hsCRP, Na, K, Cl, P, Mg, Ca were determined on automated analyzer systems. All pregnant women were categorized into 2 study and a control group on the basis of presence of hypertensive disorders in the current pregnancy. Statistical analysis was performed in 12 statistical program STATISTICA (StatSoft Inc., Tulsa, OK, USA). The data are presented in tables and graphs, the level of significance p is interpreted statistically significant if the p value was less than <0.05. RESULTS: Serum concentrations of sFlt-1 are statistically significantly different in all study groups and significantly higher in the groups with hypertensive disorders compared to healthy subjects p <0.001. Serum levels of VEGF-A are significantly lower in the preeclampsia group compared to healthy control group (p <0.001), while the levels of serum concentration of PlGF statistically significantly different between all groups so that the lowest values are observed in the preeclampsia group (p <0.001) compared to the other two study groups. There is no statistically significant differences in the levels of PAPP-A, biochemical parameters (glucose, AST, ALT, GGT creatinine, urea, uric acid), lipid parameters (total cholesterol, LDL, apo AI, apo B), inflammatory parameters (complete blood count, fibrinogen), hemostatic (D-dimer, vWF-antigen) and electrolyte status (Na, K, Cl, P, Mg, Ca), p> 0.05. Levels of free ßhCG and HDL cholesterol levels are significantly lower, while the value of hsCRP and triglycerides significantly higher in the group of women with preeclampsia compared to the healthy control group. Serum concentrations of sFlt-1 over 865 pg/ml have a sensitivity of 93% and specificity of 81.5% in predicting preeclampsia, while serum PlGF concentration below 60 pg/ml, a sensitivity of 88.4% and a specificity of 79.6% in predicting preeclampsia. Serum concentrations of sFlt-1, VEGF-A and PlGF do not show a statistically significant difference compared to the age of pregnant women and the number of previous pregnancies p> 0.05. Serum concentrations of sFlt-1 and PlGF are significantly different in relation to the weight of the newborn, so that the lower values of both proteins are in the group of infants with birth weight below 1500 gr. in relation to the body weight between 2800-3300 gr., p <0.001. There is also lower concentrations of sFlt-1 and PlGF in a group with deliveries before 33 weeks of gestation compared to the deliveries after 37 week of gestation, p <0.001. Serum concentrations of sFlt-1 and PlGF are significantly different in relation to the mother's body mass index so that the lower values of sFlt-1 and PlGF are in the group of women with a body mass index below 25 in relation to a group with a body mass index over 30 kg/m2, p <0.001. Serum concentrations of sFlt-1 in the first trimester of pregnancy were significantly associated with the parameters of inflammation (hsCRP), diastolic blood pressure and levels of free ßhCG. It is also observed a significant correlation between PlGF with a body mass index, systolic blood pressure and hsCRP concentration in the first trimester of pregnancy. CONCLUSION: The levels of anti-angiogenic protein sFlt-1 are higher in the group of pregnant women with preeclampsia than in the group with chronic and gestational hypertension and the control healthy group. Levels of proangiogenic VEGF-A protein are significantly lower in the preeclampsia group and group with gestational and chronic hypertension compared to the control group. Serum levels of proangiogenic PlGF protein are significantly lower in the preeclampsia group than in the group with chronic and gestational hypertension and the control group. Serum concentrations of placental protein free ßhCG and HDL cholesterol are significantly lower, while the value of hsCRP and triglycerides significantly higher in the preeclampsia group compared to the control group. Among pregnant women with hypertensive disorders in pregnancy and healthy pregnant women there are no significant differences in the values of placental PAPP-A protein, biochemical parameters (glucose, AST, ALT, GGT creatinine, urea, uric acid), lipid parameters (total cholesterol, LDL, apo AI, apo B), inflammatory parameters (complete blood count, fibrinogen), hemostatic (D-dimer, vWF-antigen) and electrolyte status (Na, K, Cl, P, Mg, Ca). Serum concentrations of sFlt-1 and PlGF are significantly different in relation to gestational age at delivery and newborn body weight and are lower in group with preterm delivery and newborns with lower birth weight. Serum concentrations of sFlt-1 are significantly different compared to body length and Apgar score, so that the higher values of sFlt-1 are associated with better outcome of newborns (greater body length and better APGAR score). Serum concentrations of sFlt-1, VEGF-A and PlGF are not different significantly with respect to age of pregnancy and the number of previous pregnancies. The levels of sFlt-1 and PlGF represents helpful markers in prediction of preeclampsia in the first trimester of pregnancy.

La présence de métastases est un facteur de mauvais pronostic dans les cancers solides et une meilleure compréhension de la dissémination tumorale est nécessaire afin d'améliorer la prise en charge de ces formes avancées. Les cellules tumorales circulantes (CTC) représentent un intérêt majeur dans la pathologie tumorale, d'une part sur le plan clinique en tant que marqueur prédictif et pronostique et d'autre part sur le plan de la compréhension des mécanismes impliqués dans la formation des métastases. Les CTC sont rares et hétérogènes et restent mal caractérisées, et ce, particulièrement dans le cancer colorectal. Une partie de ces cellules aurait un phénotype de cellules initiatrices de tumeur (CIT) leur permettant de former des métastases, de résister aux traitements et par conséquent d'être responsables des rechutes. Une meilleure connaissance des CTC possédant un phénotype de CIT représente donc un enjeu majeur. L'objectif de ce travail a été d'identifier et de caractériser les CTC avec un potentiel de cellules initiatrices de tumeur dans le cancer colorectal en se basant sur les propriétés fonctionnelles des CIT. Nous avons ainsi, pour la première fois, pu établir deux modèles permettant de répondre à cet objectif. D'une part des lignées de CTC avec un fort potentiel de CIT obtenues à partir d'échantillons sanguins de patients atteints de cancer colorectal, et d'autre part, nous avons mis en place un modèle murin de dissémination tumorale par xénogreffe orthotopique permettant d'isoler les CTC
Liver or lung metastases represent a poor prognosis in colorectal cancer patients and better understanding tumor spreading became essential to improve patient care. Circulating tumor cells (CTC) is considered as a promising tool, both as prognostic marker and as tool to study mechanisms involved in metastasis development. CTCs are rare and heterogeneous and remain poorly characterized especially in colorectal cancer. It is accepted that at least some of the CTC have a tumor initiating cell (TIC) phenotype that could be responsible for metastasis, chemoresistance and consequently lead to relapse. A deep characterization of CTC became thus an urgent unmet need. The aim of this work was to identify and characterize CTC with TIC properties in colorectal cancer, on the basis of their functional properties. To reach this aim, we established for the first time and characterized CTC lines from blood sample of colorectal cancer patient, and we also developed an orthotopic xenograft mouse model in which tumoral cells are circulating in the blood

Estudo longitudinal, prospectivo, comparativo de avaliação dopplervelocimétrica das artérias uterinas direita e esquerda em 37 gestantes normais em três períodos da gestação, acompanhadas na Clínica Obstétrica do HCFMUSP. Análise da relação S/D, índice de pulsatilidade e índice de resistência, relação com o número de incisuras e com posição da placenta. Foi observada redução nos valores dos índices durante a gestação. A relação S/D AUTE com placenta a direita apresentou média superior. A incidência de incisura foi maior no período entre a 16ª e a 24ª semana de gestação. A análise da relação entre os índices dopplervelocimétricos e a presença de incisura não teve resultados significativos
Prospective, longitudinal, comparative study of Doppler evaluation of the right and left uterine arteries of 37 healthy women with singleton pregnancies, performed in three periods of pregnancy, at the Pre-Natal Care Unit HCFMUSP. S/D ratio, pulsatility index and resistance index, number of notches and placental position were analysed. A decrease in the indices was observed with advancing gestation. When placenta was on the right side, the left uterine artery S/D ratio showed increased mean values. The incidence of uterine notch was higher between the 16th and 24th week of gestation in both arteries. No correlation was found between the presence of uterine notch and the placental position

L'objet de la thèse est la dimension spatiale des rapports sociaux qui se manifestent dans les espaces frontaliers. Au tournant des années 1990, de nouvelles relations internationales émergent de la scène écroulée du bloc de l'Est et de l'accélération sans précédent du processus de mondialisation. C'est l'essor du capital sans nationalité dans un monde où les frontières n'auraient plus de sens. Le monde débordant de nations se double d'un monde sous emprise des marchés. Ce contexte oriente, influence les politiques internationales, la nature et la forme des relations entre pays et populations, mais aussi, les politiques nationales en matière de sécurité, de " gestion " de l'immigration et du rapport aux étrangers. De manière multiscalaire et par le recours à diverses méthodes empiriques (observations, entretiens...), les pratiques des acteurs sont étudiées sur plusieurs terrains-laboratoires : États-Unis / Mexique, Espagne / Maroc, Israël / Liban / Palestine. Quel est le rôle des frontières dans la production et la reproduction des rapports sociaux ? Qu'est-ce que les relations frontalières, les pratiques sociales de l'espace frontalier, révèlent des rapports sociaux ? Que peut-on comprendre des rapports de forces et des contradictions antagoniques ou non entre acteurs aux situations asymétriques dans le cadre des rapports sociaux ? Par une approche de géographie sociale et de géopolitique, à partir de la dimension spatiale (espace frontalier) des faits sociopolitiques et économiques la thèse propose une analyse des rapports sociaux pour contribuer à expliquer les relations internationales, les conflits, rapports de dominations et le rôle des asymétries frontalières.

Numerical experiments are used to study the wind- and buoyancy-modulated along-shore circulation over the Texas-Louisiana continental shelf inshore of 50-m water depth. Most attention is given to circulation in the non-summer flow regime. A major focus of this study is on a unique along-shore flow phenomenon – convergent along- shore flows, which is controlled jointly by wind forcing and buoyancy fluxes from the Mississippi-Atchafalaya river plume. The second problem addresses the forcing effect of buoyancy on the general along-shore circulation pattern over the shelf in non-summer. The convergent along-shore flows are characterized by down-coast flow from the northern shelf encountering up-coast flow from the southern shelf. This phenomenon is explored for both weather band and seasonal timescales. For the weather band, investigations are focused on non-summer convergent events. The formation of convergent flows is primarily caused by along-coast variation in the along-shore component of wind forcing, which in turn is due to the curvature of the Texas-Louisiana coastline. In general, along-shore currents are well correlated with along-shore winds. However, the points of convergence of currents and winds are not co-located; but rather, points of convergence of currents typically occur down-coast of points of convergence of wind. This offset is mainly caused by buoyancy forcing that forces down-coast currents and drives the point of convergence of currents further down-coast. No specific temporal shift pattern is found for the weather-band convergence, whereas monthly

La nouvelle « Bartleby The Scrivener. A Story of Wall-Street » pose des questions de lecture et d’interprétation littéraire. Grâce à des approches ayant le discours pour objet ou moyen de connaissance (rhétorique, étymologie, psychanalyse, pragmatique) de même qu’aux écrits de Herman Melville, il s’agit de cerner ce que représente Bartleby, qualifié d’« unaccountable » (inexplicable). Ce mot organise l’étude. Entier ou décomposé en morphèmes, dans une première partie, il met en évidence des univers de sens où Bartleby se montre marginal et court-circuite les systèmes : l’univers du langage (« unaccountable » : inénarrable), celui de la loi (« count » : chef d’accusation) et celui des chiffres (« account, count » : compte, compter). Une seconde partie rattache les pistes de lecture implicites ainsi dégagées aux thématiques de l’« inexplicable », explicites dans le texte, permettant une interprétation touchant l’univers des lettres, leur pérennité et leur circulation par le biais de la lecture et de l’interprétation.
The short story “Bartleby The Scrivener. A Story of Wall Street” raises questions about reading and literary interpretation. Using approaches where language is the object or means of knowledge (rhetoric, etymology, psychoanalysis, pragmatics) along with writings from Herman Melville, we aim to consider what is represented by Bartleby, who is often described as unaccountable. This very word structures the study. The first part of the thesis examines this word, taken as a whole or broken down into morphemes, as conveying universes of meaning in which Bartleby appears as marginal, short-circuiting diverse systems: the universe of language (unaccountable), the universe of the law (count) and the universe of the numbers (account, count). The second part links the implicit threads of meaning thus revealed to the theme of the strange and unexplainable (unaccountable), explicit in the text, allowing for interpretations bearing on the world of literary texts, their conveyance and circulation through reading and interpretation.

Previous studies have suggested that advection from the Mexican Plateau (MP) may influence rainfall over Texas in spring and summer; generally air ascends over the cordillera and descends over the southern plains. The two mechanisms may link the northern Mexico drought to Texas drought. Observations and the Community Earth System Model are used in this study to describe the 2011 Texas-northern-Mexico drought and examine the role of the MP on the hydro-climate over the southern US, providing implications for the linkage between the MP and rainfall over Texas. A control run and three experimental runs were performed with prescribed sea surface temperatures and sea ice fractions. The results show that when the MP becomes dry, rainfall declines locally and downstream. During the spring, the dry air brought to Texas by prevailing westerly winds suppresses local convection; but dry air advection from the highlands has little influence on rainfall over Texas during the summer when Texas is no longer in the downstream areas. During the summer, a warmer MP draws moist air over the peripheral low elevation areas to the highlands; it bends the low-level jet towards the highlands and an anti-cyclonic flow anomaly forms over the southern US, which causes air to diverge and tends to reduce rainfall over the southern US.
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A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, in part fulfilment of the requirements for the degree Master of Medicine in Internal Medicine. 1993.
Normal thyroid physiology and pathophysiOlogy with reference to non-thyroidal illness is reviwed, including infections, specific disease states and drugs and their effects on thyroid function tests. A review of the literature reveals that following almost any infection the serum T4 and T3 decrease as a result of diminished secretion of TSH and thyroxine, accelerated T4 disappearance, inhibition of hormone binding to transport proteins and decreased peripheral T4 to T3 conversion. [Abbreviated Abstract. Open document to view full version]
AC2017

Large-scale circulation patterns have a significant modulating influence on local hydro-meteorological variables, and consequently on water availability. An understanding of the influence of these patterns on the hydrological cycle, and the ability to timely predict their impacts, is crucial for water resources planning and management. This dissertation focusses on the influence of two major large-scale circulation patterns, the El Niño Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO), on the Rio Grande basin and the state of Texas, US. Both study areas are subject to a varying climate, and are extremely vulnerable to droughts, which can have devastating socio-economic impacts. The strength and spatial correlation structure of the climate indices on gauged precipitation was first established. Precipitation is not linearly related to water availability; therefore a land surface model (LSM), with land use land cover constant, was used to create naturalized flow, as it incorporates all necessary hydro-meteorological factors. As not all ENSO events are created equal, the influence of individual El Niño and La Niña events, classified using four different metrics, on water availability was examined. A general increase (decrease) in runoff during El Niños (La Niñas) was noted, but some individual events actually caused a decrease (increase) in water availability. Long duration El Niños have more influence on water availability than short duration high intensity events. Positive PDO enhances the effect of El Niño, and dampens the negative effect of La Niña, but when it is in its neutral or transition phase, La Niña tends to dominate climatic conditions and reduce water availability. LSM derived runoffs were converted into 3-month Standardized Runoff Indices (SRI 3) from which water deficit durations and severities were extracted. Conditional probability models of duration and severity were developed and compared with that based on observed precipitations. It was found that model derived information can be used in regions having limited ground observation data, or can be used in tandem with observation driven conditional probabilities for more efficient water resources planning and management. Finally a multidimensional model was developed, using copulas, to predict precipitation based on the phase of ENSO and PDO. A bivariate model, with ENSO and precipitation, was compared to a trivariate model, which incorporates PDO, and it was found that information on the state of PDO is important for efficient precipitation predictions.

Commuter rail is increasingly popular as a means to introduce rail transportation to metropolitan transportation systems. The long-term benefits of commuter rail include the addition of capacity to the transportation system, providing a quality commute alternative, and shifting land use toward transit-oriented development patterns. The success of a commuter rail system depends upon cultivating a ridership base upon which to expand and improve the system. Cultivating this ridership is dependent upon offering a quality transportation option to commuters. Characteristics of commuter rail systems in the United States present challenges to offering quality service that must be overcome. Commuter rail has been implemented only on existing rail right-of-way (ROW) and infrastructure (depending upon condition) in the United States. Existing rail ROW does not often coincide with current commercial and residential demand centers and necessitates the use of a circulator system to expand the service boundary of commuter rail to reach these demand centers. The commuter rail circulator network design problem (CRCNDP) addresses a particular aspect of the commuter rail trip, seeking to improve the performance of the entire system through accurately modeling the portion of the trip from rail station to the final destination. This final leg includes both the trip on the circulator vehicle and the walking trip from the circulator stop to the final destination. This dissertation seeks to provide an innovative mathematical programming formulation and solution methodology for the CRCNDP and apply this method to a case study.

Indiana University-Purdue University Indianapolis (IUPUI)
Recent advancements in the management of systemic glucose regulation in obesity/T2DM include drug therapies designed to utilize components of the incretin system specifically related to glucagon-like peptide 1 (GLP-1). More recently, GLP-1 has been investigated for potential cardioprotective effects. Several investigations have revealed that acute/sub-acute intravenous administration of GLP-1 significantly reduces myocardial infarct size following ischemia/reperfusion injury and improves cardiac contractile function in the settings of coronary artery disease, myocardial ischemia/reperfusion injury, and heart failure. Despite an abundance of data indicating that intravenous infusion of GLP-1 is cardioprotective, information has been lacking on the cardiac effects of iv GLP-1 in the MetS or T2DM population. Some important questions this study aimed to address are 1) what are the direct, dose-dependent cardiac effects of GLP-1 in-vivo 2) are the cardiac effects influenced by cardiac demand (MVO2) and/or ischemia, 3) does GLP-1 effect myocardial blood flow, glucose uptake or total oxidative metabolism in human subjects, and 4) are the cardiac effects of GLP-1 treatment impaired in the settings of obesity/MetS and T2DM. Initial studies conducted in canines demonstrated that GLP-1 had no direct effect on coronary blood flow in-vivo or vasomotor tone in-vitro, but preferentially increased myocardial glucose uptake in ischemic myocardium independent of effects on cardiac contractile function or coronary blood flow. Parallel translational studies conducted in the humans and Ossabaw swine demonstrate that iv GLP-1 significantly increases myocardial glucose uptake at rest and in response to increases in cardiac demand (MVO2) in lean subjects, but not in the settings of obesity/MetS and T2DM. Further investigation in isolated cardiac tissue from lean and obese/MetS swine indicate that this impairment in GLP-1 responsiveness is related to attenuated activation of p38-MAPK, independent of alterations in GLP-1 receptor expression or PKA-dependent signaling. Our results indicate that the affects of GLP-1 to reduce cardiac damage and increase left ventricular performance may be impaired by obesity/MetS and T2DM.

BACKGROUND: Magnetic resonance imaging and echo color Doppler (ECD) scan techniques do not accurately assess the cerebral venous return. This generated considerable scientific controversy linked with the diagnosis of a vascular syndrome known as chronic cerebrospinal venous insufficiency (CCSVI) characterized by restricted venous outflow from the brain. The purpose of this study was to assess the cerebral venous return in relation to the change in position by means of a novel cervical plethysmography method. METHODS: This was a single-center, cross-sectional, blinded case-control study conducted at the Vascular Diseases Center, University of Ferrara, Italy. The study involved 40 healthy controls (HCs; 18 women and 22 men) with a mean age of 41.5 +/- 14.4 years, and 44 patients with multiple sclerosis (MS; 25 women and 19 men) with a mean age of 41.0 +/- 12.1 years. All participants were previously scanned using ECD sonography, and further subset in HC (CCSVI negative at ECD) and CCSVI groups. Subjects blindly underwent cervical plethysmography, tipping them from the upright (90 degrees ) to supine position (0 degrees ) in a chair. Once the blood volume stabilized, they were returned to the upright position, allowing blood to drain from the neck. We measured venous volume (VV), filling time (FT), filling gradient (FG) required to achieve 90% of VV, residual volume (RV), emptying time (ET), and emptying gradient (EG) required to achieve 90% of emptying volume (EV) where EV = VV - RV, also analyzing the considered parameters by receiver operating characteristic (ROC) curves and principal component mathematical analysis. RESULTS: The rate at which venous blood discharged in the vertical position (EG) was significantly faster in the controls (2.73 mL/second +/- 1.63) compared with the patients with CCSVI (1.73 mL/second +/- 0.94; P = .001). In addition, respectively, in controls and in patients with CCSVI, the following parameters were highly significantly different: FT 5.81 +/- 1.99 seconds vs 4.45 +/- 2.16 seconds (P = .003); FG 0.92 +/- 0.45 mL/second vs 1.50 +/- 0.85 mL/second (P < .001); RV 0.54 +/- 1.31 mL vs 1.37 +/- 1.34 mL (P = .005); ET 1.84 +/- 0.54 seconds vs 2.66 +/- 0.95 seconds (P < .001). Mathematical analysis demonstrated a higher variability of the dynamic process of cerebral venous return in CCSVI. Finally, ROC analysis demonstrated a good sensitivity of the proposed test with a percent concordant 83.8, discordant 16.0, tied 0.2 (C = 0.839). CONCLUSIONS: Cerebral venous return characteristics of the patients with CCSVI were markedly different from those of the controls. In addition, our results suggest that cervical plethysmography has great potential as an inexpensive screening device and as a postoperative monitoring tool.