Dissertations / Theses on the topic 'Circulation of texts'
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Palmieri, Brooke Sylvia. "Compelling reading : the circulation of Quaker texts, 1650-1700." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10055389/.
Full textLove, Rosalind Claire. "The texts, transmission and circulation of some eleventh-century Anglo-Latin saints' lives." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272404.
Full textHarlig, Alexandra M. "Social Texts, Social Audiences, Social Worlds: The Circulation of Popular Dance on YouTube." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557161706452516.
Full textYoo, Jungmin. "Materiality and Writing: Circulation of Texts, Reading and Reception, and Production of Literature in Late 18th-century Korea." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065154.
Full textEast Asian Languages and Civilizations
Burghart, Marjorie. "Remploi textuel, invention et art de la mémoire : les Sermones ad status du franciscain Guibert de Tournai († 1284)." Thesis, Lyon 2, 2013. http://www.theses.fr/2013LYO20093.
Full textThe collection of ad status sermons by the Franciscan Guibert de Tournai (d. 1284), rooted in the new art of preaching that was developing in the thirteenth century, is best known for its particular organization, arranging the sermons according to the social position (or estate) of their audience rather than by liturgical occasions. This thesis assesses and updates our knowledge of the author and the collection, and provides an in-depth analysis of this body of work, accompanied by a complete transcription. Furthermore, the thesis paves the way for a reinterpretation of the ways in which Guibert used and adapted earlier texts, and it proposes a new understanding of the ad status division, in light of mnemonics and the art of memory.The first chapter assesses our knowledge of Guibert de Tournai. A child of the Flemish bourgeoisie, he remained faithful to his land of origin and to the men he knew there, long after his studies and his engagement in the Franciscan order had led him to Paris. Intellectually fertile in a variety of genres, his works hint at a personality passionate about mysticism and contemplation. A pre-eminent figure in the Parisian intellectual landscape of the 1260s, connected to the key political and intellectual figures of his time, he was interested in questions regarding the acquisition and transmission of knowledge, and evidently in the preaching we know – thanks to Parisian reportationes – that he practiced until his twilight years.The second chapter offers a detailed presentation and analysis of the ad status collection. There are many extant manuscripts, and their analysis is complicated by several inconsistencies in the transmission of the work, but overall and over time the text seems relatively stable. The content of the collection, systematically analysed, provides an excellent example of the “modern sermon” in the way it arranges the material for preaching, drawing on numerous distinctiones to structure the texts.The third chapter explores the link between Guibert and intertextuality or textual reuse. The Franciscan master took much of his material from other works; his reuse of the Sermones vulgares of Jacques de Vitry in his ad status sermons has been known for a long time, but he also found much of his preaching material for sermons on the sacraments in the work of Guillaume d’Auvergne. Guibert's appropriation of the work of Jacques de Vitry, measured through the use of his predecessor's exempla, is revealed to be less systematic and more complex than scholars would otherwise have predicted, demonstrating just how, and to what extent, textual reuse was integral to the creation process for Guibert as well as for other medieval authors. The role of the works of Guibert as reservoirs of material, in turn themselves reused in works of various genres and authors, is demonstrated through the analysis of a number of later texts.The final chapter proposes a new consideration of Guibert's choice of constructing his collection as an ad status text. The composition of sermons according to the social position of the audience can be understood, in light of the art of memory, as an ingenious mnemonic tool for the organisation of preaching material rather than as a mirror of a real or ideal society. In turning the status into “lieux de mémoire”, Guibert created a thematic classification of preaching material according to topoi attached to the estates
Demoux, Anna. "Des sources ibériques du théâtre élisabéthain et jacobéen : réseaux d'influence, circulation des textes, dramaturgie et théâtralité." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAL008.
Full textThis dissertation proposes to reassess the status of Iberian sources within a corpus of English plays staged between the last years of the reign of Elizabeth I and the beginning of the Jacobean era, a period marked by deep socio-cultural changes. It does not focus on the well-known and often studied tension between Hispanophilia and Hispanophobia which characterises the representation of Anglo-Iberian relations at the time, but considers this relationship from a textual, cultural and aesthetic perspective including the go-betweens that, at a European scale, enabled these texts to circulate while they were altering them. This work thus deals with the networks of influence of Iberian texts belonging to 15th-and-16th-century court culture and the impact they had on early modern English drama. In particular, it tackles the sentimental romance Tractado de amores de Arnalte y Lucenda by Diego de San Pedro, court poetry by Juan Boscán and Garcilaso de la Vega with the long poem Leandro and sonnet XXIX « Pasando el mar Leandro el animoso », the pastoral romance Los siete libros de La Diana by Jorge de Montemayor and the anonymously published picaresque tale La vida de Lazarillo de Tormes, y de sus fortunas y adversidades. These works are set in conversation with didactic and philosophical texts such as El libro aureo de Marco Aurelio by Antonio de Guevara, The Courtier by Baldassare Castiglione translated by Boscán and El Examen de Ingenios by Juan Huarte de San Juan: they all deal with the figure of the courtier and the notion of « service ». As to the corpus of English dramatic texts chosen for this study, it is mainly composed of plays by Shakespeare, notably The Two Gentlemen of Verona, Love’s Labour’s Lost, The Merry Wives of Windsor, Twelfth Night et The Winter’s Tale. These works are related to other contemporary writings: Hero and Leander by Christopher Marlowe, Blurt Master Constable by Thomas Dekker, along with texts by John Lyly and Ben Jonson. By supplementing and redirecting the studies addressing plots and characters in the English dramatic literature, the traditional field of investigation of Source Studies, this dissertation discusses these elements from a perspective which takes into account the societal and theatrical dimensions inherent to the literature born out of the Iberian court society : this innovative literature reflects, shapes and questions especially the theatricality of an environment where individuals never cease to stage themselves. Alternately authors, dedicatees and key-characters and figures of these fictions they enjoy thoroughly, the members of the Iberian court society thus provide early modern English writers with a playground conducive to dramaturgical innovation and experimentation
Stone, Heather Brenda. "Companionable forms : writers, readers, sociability, and the circulation of literature in manuscript and print in the Romantic period." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:63f652fc-c4c2-4c3a-bc5c-893d4b922db1.
Full textSchoenecker, Aurore. "Les traductions françaises de l'espagnol et le marché du livre (1600-1660) : enquête sur une pratique d'écriture." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE090.
Full textThe literary influence exercised by Golden Age Spain on France in the first half of the 17th century is related to a very considerable mass of editorial activity. This thesis, which combines the history of the book and literary history, studies French translations of Spanish texts which circulated in France between 1600 and 1660 - translations concerning texts of all kinds (religious, literary, scientific, technical, etc.).In order to evaluate this editorial activity, a bibliometric enquiry must first be carried out. This enquiry allows us to reconstitute the history of of the circulation of this material in print. The principal centres of production are identified and the production of the workshops of the booksellers’ operating in this market are examined. The analysis then shifts to the activity of translation itself, in all its diversity. The profiles of the different principal translators from Spanish to French are laid out: the professional translator, the enlightened amateur, the printer, the cleric, the physician, etc. Particular attention is paid to men of letters who attempt to conciliate what is perceived as lowly hackwork with their literary ambitions. Finally, the translators’ practices themselves are the object of study, through comparison, using textual analysis as well as examining questions of format and layout, of different (concurrent or successive) translations of the same text. Account is thus made of the diverse motivations of these versions and the specificity of each writing project and publication. Taking as its base a large swathe of writing produced in French often neglected by literary history, this study of the penetration of Spanish culture in France and of the world of translators looks anew at the relation between writing and publication, as well as at the editorial role in the construction of literary legitimacy
Kim, Hui-Teak. "La circulation du texte : valeur énonciative et communication." Paris 10, 2007. http://www.theses.fr/2007PA100062.
Full textWe have objective to establish the model of the textual communication distinct from the model of the oral communication. With this intention, it is initially advisable to illustrate the value of the text as a statement in linguistics, through the comparison with the term "speech". Because the interlocutors cannot be located in space-time simultaneity, it is necessary to examine the factors relating to the textual communication, for example, the relations existing between the text and the subjects (author and readers), the question of time, etc. To establish the model of the textual communication, on the one hand, we count on triple mimèsis of Paul Ricœur. In addition, we underline the plurality of interpretation. Various interpretations of a text do not exist separately but they maintain the interactive relations. Furthermore, through these relations, the interpretations shape synchronically a topographic plan. This one is not fixed but transformed diachronically. We can define these textual interactions as textual circulation. By this circulation, a text can maintain its vitality, namely its presence
Vettoretti, Guido. "Paleoclimate tests of a model of the atmospheric general circulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63759.pdf.
Full textAkel, Ibrahim. "Ahmad al-Rabbât al-Halabî : sa bibliothèque et son rôle dans la réception, diffusion et enrichissement des Mille et une nuits." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCF016/document.
Full textThe aim of this thesis is to bring to light the unknown figure of Ahmad al-Rabbât al-Halabî, a Syrian bookseller, who lived between the second half of the eighteenth century and the first half of the nineteenth century, to catalog and present his manuscripts and to investigate the users « readers » of this cultural archive: it can provide concrete answers to questions raised in the Arabic literature, the creation and circulation of texts. The research led to identify about 240 volumes, scattered around the world, from the initial library of al-Rabbât. The margins of these manuscripts contain a large number of reading certificates written by many generations of readers.The work on the manuscript sources also presented an opportunity to create a database of the copyists, the owners and the readers of manuscripts, and to determine the role played by Western travelers and consular agents in the production and the history of the manuscripts
Livini, Andrea. "Étude de la circulation de la Cena Cypriani durant le Moyen-Âge (avec édition de textes)." Paris, EHESS, 2011. http://www.theses.fr/2011EHES0006.
Full textMy doctoral thesis is entirely dedicated to the study of the Cena Cypriani, a bizarre and comic text that proposes a strange biblical parody, depicted as a biblical banquet. The first part of my doctoral thesis is completely dedicated to the original text, wherein I study the tradition of the manuscripts of the Cena and where I propose some critical studies of its codices in order to provide a new critical edition of the text (see pages 364-402). Following this, l propose some literary, linguistic and sociologie studies of the text by demonstrating that the Cena Cypriani was a very complex literary exercise. During my research, I had the possibility of posing the question about the Cena’s literary sources, as for example, the Iudicium Ceci et Pistoris and the Testamentum Porcelli. Through this, l was able to elaborate the hypothesis that the Cena took place during the Vth century, written to entertain the elites, most likely during banquets. In the second part of my thesis, I tried to understand the reason of the Cena's circulation during the Middle Ages. The Early Medieval re-writing of the Cena Cypriani - the Cena Hrabani and the Cena Nuptialis - represents very important instruments for my research because they allow me to understand the continuity between the two texts ; they were very useful to understand the didactic and religious function of the Cena and to justify its medieval transmission and importance
Sheen, Jeanne Erica. "The institution of early modern theatre : gender and the circulation of meaning in the Shakespearean text." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243334.
Full textPayne, John Thomas. "The effects of left hepatic vein ligation on hepatic circulation, function and microanatomy." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/53241.
Full textMaster of Science
Landereau, Pascal. "Modèles macroscopiques pour les écoulements monophasiques en milieu poreux fracturé : application aux tests de puits." Paris, ENSAM, 2000. http://www.theses.fr/2000ENAM0025.
Full textMILLIOTTE, MARIE-EVE. "Evaluation de l'etat neurologique apres circulation extra-corporelle : interet des tests psychometriques, de la scintigraphie au ceretec et de la cartographie eeg ; a propos de 22 observations." Besançon, 1994. http://www.theses.fr/1994BESA3042.
Full textMbu, Desiree Lem. "Expression of circulating Microrna’s (Mirnas) in blood of mixed ancestry subjects with glucose intolerance." Thesis, Cape Peninsula University of Technology, 2018. http://hdl.handle.net/20.500.11838/2816.
Full textBackground: Early detection of individuals who are at risk of developing Glucose Intolerance would decrease the morbidity and mortality associated with this disease. MicroRNA is one of the most widely studied biomolecules involved in epigenetic mechanisms, hence it offers unique opportunities in this regard. Circulating microRNAs are associated with disease pathogenesis during the asymptomatic stage of disease. This has therefore attracted a lot of attention as a potential biomarker for identifying individuals who have an increased risk of developing Glucose Intolerance. The identification of high risk biomarkers for Glucose Intolerance will go a long way to eliminate the possible complications that arise due to late diagnosis and treatment of Glucose Intolerance. This could ultimately lead to better ways to prevent, manage and control the Glucose Intolerance epidemic that is rampant worldwide. The aim of the study is to investigate expression of circulating microRNA’s in blood of mixed ancestry subjects with glucose intolerance. Methods: A quantitative cross-sectional study design involving 36 individuals [who were age, gender and BMI (Body Mass Index) matched] from a total population of 1989 participants of mixed ancestry descent, residing in Bellville South, South Africa was used. Participants were classified as controls (normoglycemic), pre-diabetic (preDM) and diabetic (DM) (screen detected diabetic) according to WHO criteria of 1998. MicroRNAs were extracted from serum using the Qiagen miRNeasy Serum/Plasma Kit (ThermoFisher). The purified micro RNAs were reverse-transcribed to cDNA (complementary deoxyribonucleic acid) using the Qiagen RT2 First Strand Kit. Then, using Qiagen miScript SYBR Green PCR kit and miScript miRNA PCR arrays (ThermoFisher), the real time polymerase chain reaction was done to determine the expression profile the circulating micro RNAs present in the serum of the participants. Results: The 36 participants were evenly divided into 3 groups of 12 participants each as mentioned earlier. There were significant differences between groups in the waist (cm) (p=0.0415) and waist/hip ratio (p=0.0011) with highest values in the DM group and lowest in the normal group. Clinical parameters varied significantly according to glycemic status. As expected, the FBG (mmol/L) (p<0.0001), 2 HRs Post Glucose (mmol/L) (p<0.0001), HbA1c (%) (p=0.0009), Fasting Insulin (mIU/L) (p=0.0039), were all highest in the DM and lowest in the control group. In contrast, the 2 HRs Post Insulin (mIU/L) (p = 0.0027) was highest in the preDM group and lowest in the normal group, while the Glucose/Insulin ratio (p=0.0477) was highest in the normal group and lowest in the preDM group. Triglycerides (mmol/L) (p=0.0043) and Total Chol (mmol/L) (p=0.0429) were significantly increased through the three groups, with highest values in the DM group and lowest in the normal group. Furthermore, 12 of the 84 miRNAs studied were expressed through all the 3 groups and they exhibited both inverse and positive correlations between the clinical parameters, especially the glucose parameters (Fasting blood glucose, 2 hours post glucose, Fasting blood insulin, 2 hours post insulin and Glycated Hemoglobin).
Touitou, Robert Cohen Robert. "Intérêt des tests de diagnostic rapide de la grippe chez l'enfant dans la prise en charge des syndromes grippaux ou de la fièvre isolée en période de circulation des virus de la grippe." Créteil : Université de Paris-Val-de-Marne, 2006. http://doxa.scd.univ-paris12.fr:80/theses/th0236140.pdf.
Full textTrollé, Xavier. "Développement d'un modèle de gestion des échanges de masse et d'énergie généralisable aux différents couverts dans les GCM : analyses et tests de nouveaux concepts." Paris 6, 2008. http://www.theses.fr/2008PA066676.
Full textGibbs, Jason. "Experimental Determination of Lift and Lift Distributions for Wings In Formation Flight." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/31301.
Full textMaster of Science
Hernandez, Raymundo. "Circulatory and Respiratory Responses to Cycle Ergometry at Different Pedal Rates." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc503894/.
Full textMontmerle, Stéphanie. "Lung function in micro- and in hypergravity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-332-9/.
Full textFonteneau, Andréa. "Le canal sodique voltage-dépendant Nav1.5 : expressions pulmonaires et rôles potentiels dans la fonction respiratoire chez la souris." Thesis, Nantes, 2018. http://www.theses.fr/2018NANT1018/document.
Full textNav1.5 sodium channel, encoded by the Scn5a gene, is necessary for action potential in cardiomyocytes. However, its expression has been described in various contexts and has been associated with new functions. An expression has been recorded in airway smooth muscle, suggesting an involvement of Nav1.5 in respiratory function. The aim of the work has been to describe the expressions and to highlight the potential roles of Nav1.5 in mice breathing. Histological assay has confirmed Nav1.5 expression in airway smooth muscle in situ, but a major expression site has been showed at the plasma membrane of “cardiomyocytes” located in pulmonary veins. Airway contractility assessments were made on knock-out Scn5a+/- mice. Ex vivo isolated trachea contractility test showed a decrease of contraction for Scn5a+/- mice and for WT mice pre-incubated with sodium blockers ajmaline or ketamine.This effect was confirmed by in vivo whole body plethysmography, showing respiratory hyporesponsiveness on female Scn5a+/- mice. No structural of inflammatory remodelings were associated, suggesting an electrical role for Nav1.5 in respiration. Male Scn5a+/- mice do not showed a significant decrease of Nav1.5 expression, suggesting a possible hormonal influence in its regulation. To conclude, Nav1.5 contribute to mice airway contractility. It remains to determine its mechanism of action and its potential involvement in pathological context such as asthma
Junior, Jose Otavio Costa Auler. "Avaliação da função respiratória antes e depois da cirurgia cardíaca com circulação extracopórea em pacientes anestésiados, entubados e curarizados: estudo da mecânica respiratória com um novo método baseado em fluxo inspiratório. Estudo da ventilação e da oxigenação pulmonar." Universidade de São Paulo, 1986. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-27012011-173444/.
Full textThe aim of this work was to study the respiratory alterations caused by cardiac surgery under cardiopulmonary bypass in 12 randomly selected anesthetized paralyzed adult patients; 6 with acquired valvar disease and 6 with ischmic cardiopathy. Respiratory alterations were assessed by respiratory mechanics and lung ventilation-oxygenation measurements. Respiratory mechanics analyzed the respiratory system as a whole and partitioned into its components: lung and chest wall, measuring both the elastic and resistive properties were measured using a constant inflation flow followed bu a sudden occlusion. This analysis provides the maximum resistance value (Rmax), the minimum resistance value (Rmin), and the resistance caused by the uneven distribution of mechanical properties within the system (Ru), for respiratory system, lung and chest wall. This analysis is based on the frequency dependence differences of each component of respiratory system. The ventilation-oxygenation evaluation was done by the calculation of pulmonary shunt and the alveolar arterial oxygen gradient (P (A-a)O2). Both mechanical and ventilation-oxygenation measurement were done with a oxygen inspired fraction of 1 and performed 15 to 30 minutes after tracheal intubation and repeated just after thorax closure. [...]
Kosour, Carolina. "Influencia da ultrafiltração intra-operatoria na retirada de interleucinas, fator de necrose tumoral-alfa e na função pulmonar em pacientes submetidos a revascularização do miocardio com circulação extracorporea." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308813.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-15T12:28:06Z (GMT). No. of bitstreams: 1 Kosour_Carolina_D.pdf: 5835134 bytes, checksum: f6d1efdf0f5f0705f3ba5432ea02cab5 (MD5) Previous issue date: 2010
Resumo: Introdução: A operação cardíaca com utilização da circulação extracorpórea (CEC) está associada ao desenvolvimento da resposta inflamatória sistêmica e, como conseqüência, à disfunção pulmonar. O uso de ultrafiltração no intra-operatório tem sido proposto para remoção dos mediadores inflamatórios liberados durante a CEC, na tentativa de minimizar a resposta inflamatória. Objetivo: Avaliar o efeito da ultrafiltração nos níveis séricos de interleucinas, fator de necrose tumoral-alfa e na função pulmonar de pacientes submetidos à revascularização do miocárdio. Método: Foi realizado um estudo clínico, prospectivo, randomizado, com 40 pacientes, divididos em dois grupos, em um hospital terciário. Um grupo foi submetido à ultrafiltração (UF) durante a CEC e outro grupo (controle), não. Foram mensurados interleucinas (IL-ip, IL-6, IL-8), fator de necrose tumoral alfa (TNF-a), índices de troca gasosa pulmonar [PaO2/FiO2, D(A-a)O2 e VD/VT] e mecânica ventilatória (Cst e Raw) nos períodos pré-operatório, intra-operatório e dois dias de pós-operatório. As interleucinas e TNF-a foram analisadas também no perfusato, no grupo teste. Resultados: Houve aumento de IL-ip (30 minutos após a CEC e 12 horas após a operação) e IL-6 (24 e 36 horas após a operação) no grupo UF comparado ao grupo controle. Houve aumento de IL-6 em todos os tempos comparados ao tempo inicial, em ambos os grupos. Foi observada diminuição da IL-8 cinco minutos antes da CEC e aumento seis, i2, 24, e 36 horas após operação, além de aumento de TNF-a nos tempos 30 minutos após CEC, 24, 36 e 48 horas após operação. Na análise do líquido ultrafiltrado foi identificada a presença de TNF-a e das demais IL-ip, IL-6, IL-8, somente em traços. Na função pulmonar, houve piora da PaO2/FiO2, D(A-a)O2, VD/VT, cinco minutos antes da CEC, além da diminuição da D(A-a)O2 30 minutos após CEC, seis,i2, 24 e 36 horas após operação. Houve aumento da complacência estática pulmonar (Cst) e queda da resistência de vias aéreas (Raw) cinco minutos antes da CEC, além da queda da Raw seis horas após a operação nos dois grupos. Conclusão: A utilização de ultrafiltração aumentou o nível sérico das IL-i e IL-6, não interferindo na troca gasosa e na mecânica pulmonar de pacientes submetidos à revascularização do miocárdio
Abstract: Introduction: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with the development of systemic inflammatory response and, in consequence, pulmonary dysfunction. The use of ultrafiltration intraoperatively has been proposed to remove inflammatory mediators released during CPB in an attempt to minimize the inflammatory response. Objective: Evaluating the effect of ultrafiltration on the serum levels of interleukin, tumor necrosis factor alpha and pulmonary function in patients undergoing myocardial revascularization. Methods: It was carried out a prospective randomized clinical trial on 40 patients divided into two groups, in a tertiary hospital. One group was submitted to ultrafiltration (UF) during CPB whereas the other group (control), was not. It were mensured interleukins (IL-ip, IL-6, IL-8), tumor necrosis factor alpha (TNF-a), pulmonary gas exchange indexes [PaO2/FiO2, D(A-a)O2 and VD/VT] as well as respiratory mechanics (Cst e Raw) in the preoperative and intraoperative periods and postoperatively. The interleukins and TNF-a were also analyzed in the perfusate in the test group. Results: There was an increase in IL-ip (30 minutes after CPB and 12 hours after surgery) and in IL-6 (24 and 36 hours after surgery) in the UF group by comparison with the control one. There was also an increase in IL-6 at all schedulled times compared to the initial period in both groups. It was noticed a decrease in IL-8 five minutes before CPB and an increase six, i2, 24 and 36 hours after surgery in addition to an increase in TNF- a at the times 30 minutes after CPB, 24, 36 and 48 hours after surgery. On analyzing the ultrafiltrated fluid it was identified the presence of TNF-a and the other IL-ip, IL-6, IL-8 only in traces. Regarding pulmonary function, there was a worsening of PaO2/FiO2, D(A-a)O2, and VD/VT five minutes prior to CPB in addition to a decrease in D(A-a)O2 30 minutes after CPB, six, 12, 24 and 36 hours after surgery. There was an increase in the pulmonary static compliance, and a fall of the airway resistance five minutes before CPB. Also, there was a fall of the airway resistance six hours after surgery in both groups. Conclusion: The use of ultrafiltration has increased the serum levels of IL-1 and IL-6 without interfering with the pulmonary gas exchange and respiratory mechanics in patients undergoing myocardial revascularization
Doutorado
Pesquisa Experimental
Doutor em Cirurgia
Dubois, Christelle. "Confirmation de biomarqueurs pour le pronostic du sepsis et développement de tests rapides High plasma level of S100A8/S100A9 and S100A12 at admission indicates a higher risk of death in septic shock patients Top-down and bottom-up proteomics of circulating S100A8/S100A9 complexes in plasma of septic shock patients." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS521.
Full textSepsis is the 3rd leading cause of death in Western countries, with a mortality rate between 20 and 50% depending on the severity. The 'prediction' of the patient's clinical outcome is essential to establish the most appropriate treatment. Some inflammation or infection markers protein (CRP, procalcitonin) are cited for clinical follow-up of patients but lack specificity for sepsis. On the other hand, "omics" studies have generated lists of potential biomarkers of sepsis prognosis. However, none have yet been validated and/or confirmed based on the severity of the sepsis and the patient's fate. This requires access not only to fully characterized patient cohorts but also to robust and validated quantitative methods. Mass spectrometry provides a high level of specificity and high multiplex capacity and that would allow to confirm the interest of one or more of these proteins for sepsis prognosis. Immunological assays provide, in addition to sensitivity and specificity, a simple and rapid routine clinical implementation. First, a list of biomarkers identified with patient cohorts was established from the literature. Then, methods to quantify these candidate biomarkers were developed. On the one hand, we have been interested in quantifying calgranulins in plasma by developing ELISAs and mass spectrometry methods using bottom-up and top-down approaches. On the other hand, two multiplex quantification methods by mass spectrometry with and without immunopurification step according to protein concentrations have been developed to verify the relevance of the list of potential biomarkers. All these methods were applied to a cohort of 49 patients with septic shock
Ana, Jakovljević. "Prognostički značaj laboratorijskih pokazatelja uteroplacentalne cirkulacije kod trudnica sa hipertenzijom i preeklampsijom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101331&source=NDLTD&language=en.
Full textINTRODUCTION: Hypertensive disorders in pregnancy are a heterogeneous group of diseases that occur in 3-8% of all pregnancies. The most difficult forms of these diseases: preeclampsia, eclampsia and HELLP syndrome are the leading causes of maternal and fetal morbidity and mortality in relation to all other pregnancy complications. Etiopathogenesis of these diseases is still insufficiently understood but it is thought that the placenta plays a key role in the development of these complications, and that placental insufficiency, which occurs as a result of insufficient adaptation of decidual intramiometrial and parts of the spiral arteries in the first few weeks of pregnancy, leading to a reduction of utero- placental circulation and local placental hypoxia, which adversely affects the mother and the fetus. In order to elucidate the pathophysiological mechanisms of hypertensive disorders in pregnancy and to find sufficiently sensitive makers for early prediction of the most severe forms of these diseases, so far have been investigated a number of proteins involved in the processes of creation and development of placental vascular network such as vascular endothelial growth factor (VEGF-A), placental growth factor (PlGF) and soluble fms-like receptor tyrosine kinase receptor (sFlt-1). OBJECTIVE: The aim of the study was to compare serum concentration of sFlt-1, PlGF, VEGF-A, PAPP-A, freeßhCG, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apo-AI, apo B, AST, ALT, GGT, creatinine, urea, uric acid, hsCRP, Na, K, Cl, P, Mg and Ca between the group of pregnant women with preeclampsia, chronic and gestational hypertension and the control group of pregnant women in the first trimester of pregnancy between 11 and 14 weeks gestation. Also the aim was to examine whether the value of selected laboratory parameters (sFlt-1, VEGF-A and PlGF) differ in relation to gestational week at the time of birth, weight, length and APGAR scoring system of newborns. The aim was to examine whether the value of angiogenic proteins: sFlt-1, VEGF-A and PlGF differ significantly in relation to the number of previous pregnancies and age of the pregnant woman. MATERIALS AND METHODS: The study was conducted as a prospective analytical study in the Clinical Center of Vojvodina, in the period from June 2012 to February 2015. The study included a total of 143 pregnant women aged 18 - 43 years. All pregnant women included in the study were divided into two study and one control group. The first study group consisted of 43 pregnant women who developed preeclampsia during the current pregnancy. The second study group consisted of 46 pregnant women who are newly diagnosed or confirmed chronic or gestational hypertension during the current pregnancy. The control group consisted of 54 healthy pregnant women with verified physiological outcome of pregnancy at term without maternal and fetal complications. Patients were included in the study between 11 + 0 and 13 + 6 weeks of gestation. All patients had data about risk factors for developing hypertensive disorders in pregnancy. After clinical and obstetric examination all patients underwent anthropometric measurements, measurement of blood pressure, and specialized ultrasound examination to determine precise gestational age of the fetus and to determine the risk for fetal chromosomal abnormalities. All patients signed a written consent of the patient's voluntary participation in the study. Serum levels of sFlt1, VEGF-A and PlGF were determined by quantitative ELISA (R & D Systems Europe Ltd., Abingdon, UK), while glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apo-AI, apo B, AST, ALT, GGT, creatinine, urea, uric acid, hsCRP, Na, K, Cl, P, Mg, Ca were determined on automated analyzer systems. All pregnant women were categorized into 2 study and a control group on the basis of presence of hypertensive disorders in the current pregnancy. Statistical analysis was performed in 12 statistical program STATISTICA (StatSoft Inc., Tulsa, OK, USA). The data are presented in tables and graphs, the level of significance p is interpreted statistically significant if the p value was less than <0.05. RESULTS: Serum concentrations of sFlt-1 are statistically significantly different in all study groups and significantly higher in the groups with hypertensive disorders compared to healthy subjects p <0.001. Serum levels of VEGF-A are significantly lower in the preeclampsia group compared to healthy control group (p <0.001), while the levels of serum concentration of PlGF statistically significantly different between all groups so that the lowest values are observed in the preeclampsia group (p <0.001) compared to the other two study groups. There is no statistically significant differences in the levels of PAPP-A, biochemical parameters (glucose, AST, ALT, GGT creatinine, urea, uric acid), lipid parameters (total cholesterol, LDL, apo AI, apo B), inflammatory parameters (complete blood count, fibrinogen), hemostatic (D-dimer, vWF-antigen) and electrolyte status (Na, K, Cl, P, Mg, Ca), p> 0.05. Levels of free ßhCG and HDL cholesterol levels are significantly lower, while the value of hsCRP and triglycerides significantly higher in the group of women with preeclampsia compared to the healthy control group. Serum concentrations of sFlt-1 over 865 pg/ml have a sensitivity of 93% and specificity of 81.5% in predicting preeclampsia, while serum PlGF concentration below 60 pg/ml, a sensitivity of 88.4% and a specificity of 79.6% in predicting preeclampsia. Serum concentrations of sFlt-1, VEGF-A and PlGF do not show a statistically significant difference compared to the age of pregnant women and the number of previous pregnancies p> 0.05. Serum concentrations of sFlt-1 and PlGF are significantly different in relation to the weight of the newborn, so that the lower values of both proteins are in the group of infants with birth weight below 1500 gr. in relation to the body weight between 2800-3300 gr., p <0.001. There is also lower concentrations of sFlt-1 and PlGF in a group with deliveries before 33 weeks of gestation compared to the deliveries after 37 week of gestation, p <0.001. Serum concentrations of sFlt-1 and PlGF are significantly different in relation to the mother's body mass index so that the lower values of sFlt-1 and PlGF are in the group of women with a body mass index below 25 in relation to a group with a body mass index over 30 kg/m2, p <0.001. Serum concentrations of sFlt-1 in the first trimester of pregnancy were significantly associated with the parameters of inflammation (hsCRP), diastolic blood pressure and levels of free ßhCG. It is also observed a significant correlation between PlGF with a body mass index, systolic blood pressure and hsCRP concentration in the first trimester of pregnancy. CONCLUSION: The levels of anti-angiogenic protein sFlt-1 are higher in the group of pregnant women with preeclampsia than in the group with chronic and gestational hypertension and the control healthy group. Levels of proangiogenic VEGF-A protein are significantly lower in the preeclampsia group and group with gestational and chronic hypertension compared to the control group. Serum levels of proangiogenic PlGF protein are significantly lower in the preeclampsia group than in the group with chronic and gestational hypertension and the control group. Serum concentrations of placental protein free ßhCG and HDL cholesterol are significantly lower, while the value of hsCRP and triglycerides significantly higher in the preeclampsia group compared to the control group. Among pregnant women with hypertensive disorders in pregnancy and healthy pregnant women there are no significant differences in the values of placental PAPP-A protein, biochemical parameters (glucose, AST, ALT, GGT creatinine, urea, uric acid), lipid parameters (total cholesterol, LDL, apo AI, apo B), inflammatory parameters (complete blood count, fibrinogen), hemostatic (D-dimer, vWF-antigen) and electrolyte status (Na, K, Cl, P, Mg, Ca). Serum concentrations of sFlt-1 and PlGF are significantly different in relation to gestational age at delivery and newborn body weight and are lower in group with preterm delivery and newborns with lower birth weight. Serum concentrations of sFlt-1 are significantly different compared to body length and Apgar score, so that the higher values of sFlt-1 are associated with better outcome of newborns (greater body length and better APGAR score). Serum concentrations of sFlt-1, VEGF-A and PlGF are not different significantly with respect to age of pregnancy and the number of previous pregnancies. The levels of sFlt-1 and PlGF represents helpful markers in prediction of preeclampsia in the first trimester of pregnancy.
Grillet, Fanny. "Identification et caractérisation des cellules tumorales circulantes dans le cancer colorectal." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONT3510.
Full textLiver or lung metastases represent a poor prognosis in colorectal cancer patients and better understanding tumor spreading became essential to improve patient care. Circulating tumor cells (CTC) is considered as a promising tool, both as prognostic marker and as tool to study mechanisms involved in metastasis development. CTCs are rare and heterogeneous and remain poorly characterized especially in colorectal cancer. It is accepted that at least some of the CTC have a tumor initiating cell (TIC) phenotype that could be responsible for metastasis, chemoresistance and consequently lead to relapse. A deep characterization of CTC became thus an urgent unmet need. The aim of this work was to identify and characterize CTC with TIC properties in colorectal cancer, on the basis of their functional properties. To reach this aim, we established for the first time and characterized CTC lines from blood sample of colorectal cancer patient, and we also developed an orthotopic xenograft mouse model in which tumoral cells are circulating in the blood
Sakamoto, Kathia. ""Estudo dopplervelocimétrico das artérias uterinas em três períodos de gestações normais"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-03102005-152401/.
Full textProspective, longitudinal, comparative study of Doppler evaluation of the right and left uterine arteries of 37 healthy women with singleton pregnancies, performed in three periods of pregnancy, at the Pre-Natal Care Unit HCFMUSP. S/D ratio, pulsatility index and resistance index, number of notches and placental position were analysed. A decrease in the indices was observed with advancing gestation. When placenta was on the right side, the left uterine artery S/D ratio showed increased mean values. The incidence of uterine notch was higher between the 16th and 24th week of gestation in both arteries. No correlation was found between the presence of uterine notch and the placental position
Guillot, Fabien. "Les asymétries frontalières : essai de géographie sociale et politique sur les pratiques sociales et les rapports sociaux : Les cas États-Unis Mexique, Espagne Maroc, Israël Liban Palestine." Phd thesis, Université de Caen, 2009. http://tel.archives-ouvertes.fr/tel-00460936.
Full textZhang, Zhaoru. "Wind- and Buoyancy-modulated Along-shore Circulation over the Texas-Louisiana Shelf." Thesis, 2013. http://hdl.handle.net/1969.1/151180.
Full textLiva, Alexandra. "Le Réel dans le texte : lecture et interprétation de la figure de Bartleby le scribe." Thèse, 2011. http://hdl.handle.net/1866/7084.
Full textThe short story “Bartleby The Scrivener. A Story of Wall Street” raises questions about reading and literary interpretation. Using approaches where language is the object or means of knowledge (rhetoric, etymology, psychoanalysis, pragmatics) along with writings from Herman Melville, we aim to consider what is represented by Bartleby, who is often described as unaccountable. This very word structures the study. The first part of the thesis examines this word, taken as a whole or broken down into morphemes, as conveying universes of meaning in which Bartleby appears as marginal, short-circuiting diverse systems: the universe of language (unaccountable), the universe of the law (count) and the universe of the numbers (account, count). The second part links the implicit threads of meaning thus revealed to the theme of the strange and unexplainable (unaccountable), explicit in the text, allowing for interpretations bearing on the world of literary texts, their conveyance and circulation through reading and interpretation.
Ren, Tong. "The role of the Mexican Plateau in shaping rainfall over Texas." 2013. http://hdl.handle.net/2152/23172.
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Churchyard, Gavin John. "The relationship between changes in critically ill septic and non septic patients and circulating thyroxine levels." Thesis, 1993. http://hdl.handle.net/10539/22566.
Full textNormal thyroid physiology and pathophysiOlogy with reference to non-thyroidal illness is reviwed, including infections, specific disease states and drugs and their effects on thyroid function tests. A review of the literature reveals that following almost any infection the serum T4 and T3 decrease as a result of diminished secretion of TSH and thyroxine, accelerated T4 disappearance, inhibition of hormone binding to transport proteins and decreased peripheral T4 to T3 conversion. [Abbreviated Abstract. Open document to view full version]
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Khedun, Chundun 1977. "Understanding and Predicting Changes in Precipitation and Water Availability Under the Influence of Large-Scale Circulation Patterns: Rio Grande and Texas." Thesis, 2012. http://hdl.handle.net/1969.1/148245.
Full textLownes, Nicholas Earl. "The commuter rail circulator network design problem: formulation, solution methods, and applications." Thesis, 2007. http://hdl.handle.net/2152/3352.
Full textMoberly, Steven Paul. "Impaired cardiovascular responses to glucagon-like peptide 1 in metabolic syndrome and type 2 diabetes mellitus." Thesis, 2013. http://hdl.handle.net/1805/3216.
Full textRecent advancements in the management of systemic glucose regulation in obesity/T2DM include drug therapies designed to utilize components of the incretin system specifically related to glucagon-like peptide 1 (GLP-1). More recently, GLP-1 has been investigated for potential cardioprotective effects. Several investigations have revealed that acute/sub-acute intravenous administration of GLP-1 significantly reduces myocardial infarct size following ischemia/reperfusion injury and improves cardiac contractile function in the settings of coronary artery disease, myocardial ischemia/reperfusion injury, and heart failure. Despite an abundance of data indicating that intravenous infusion of GLP-1 is cardioprotective, information has been lacking on the cardiac effects of iv GLP-1 in the MetS or T2DM population. Some important questions this study aimed to address are 1) what are the direct, dose-dependent cardiac effects of GLP-1 in-vivo 2) are the cardiac effects influenced by cardiac demand (MVO2) and/or ischemia, 3) does GLP-1 effect myocardial blood flow, glucose uptake or total oxidative metabolism in human subjects, and 4) are the cardiac effects of GLP-1 treatment impaired in the settings of obesity/MetS and T2DM. Initial studies conducted in canines demonstrated that GLP-1 had no direct effect on coronary blood flow in-vivo or vasomotor tone in-vitro, but preferentially increased myocardial glucose uptake in ischemic myocardium independent of effects on cardiac contractile function or coronary blood flow. Parallel translational studies conducted in the humans and Ossabaw swine demonstrate that iv GLP-1 significantly increases myocardial glucose uptake at rest and in response to increases in cardiac demand (MVO2) in lean subjects, but not in the settings of obesity/MetS and T2DM. Further investigation in isolated cardiac tissue from lean and obese/MetS swine indicate that this impairment in GLP-1 responsiveness is related to attenuated activation of p38-MAPK, independent of alterations in GLP-1 receptor expression or PKA-dependent signaling. Our results indicate that the affects of GLP-1 to reduce cardiac damage and increase left ventricular performance may be impaired by obesity/MetS and T2DM.
Zamboni, P., E. Menegatti, P. Conforti, Simon J. Shepherd, M. Tessari, and Clive B. Beggs. "Assessment of cerebral venous return by a novel plethysmography method." 2012. http://hdl.handle.net/10454/6249.
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