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Frey Rébeillé-Borgella, Marie. "La diffusion de la révision hiéronymienne des traductions bibliques dans les livres liturgiques latins (Ve–XIIe siècle) : l’exemple des Douze Prophètes." Clotho 3, no. 2 (December 24, 2021): 167–89. http://dx.doi.org/10.4312/clotho.3.2.167-189.
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La diffusion des révisions hiéronymiennes des Bibles latines s’est faite notamment à travers les textes liturgiques latins. La présente communication s’intéresse à l’utilisation de l’oeuvre du moine de Bethléem dans les prières des livres liturgiques (missels, sacramentaires et bénédictions pontificales). Elle est centrée sur les citations des livres dits “des petits prophètes”. Si l’oeuvre de Jérôme s’impose progressivement dans la vie liturgique occidentale à partir de la deuxième moitié du VIIe et du VIIIe siècle, plusieurs missels et sacramentaires comportent aussi bien des citations de la révision de Jérôme que de versions des Vieilles latines. C’est notamment le cas de sacramentaires irlandais de la fin du VIIe siècle et du missel gallican dit Missale Gothicum, datant des années 700. À cette époque, l’oeuvre de Jérôme n’est donc pas encore utilisée par la liturgie comme un ensemble unifié. La citation et l’allusion aux anciennes traductions latines persiste même dans la péninsule ibérique et la liturgie mozarabe jusqu’au XIIe siècle. Une étude détaillée des allusions au livre II de Jonas montre que des morceaux de versets issus des Vieilles latines se sont maintenus pendant tout le Moyen-Âge dans des livres ayant recours à la Vulgate, peut-être parce qu’ils étaient passés dans la culture biblique collective. Cet article souligne donc la nécessité d’une analyse détaillée, livre liturgique par livre liturgique, pour étudier les citations de la Bible dans la liturgie latine, car une même pièce liturgique peut emprunter à plusieurs traductions différentes.
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Wolff, Étienne. "Locutions et citations latines chez Alphonse Allais." Bulletin de l'Association Guillaume Budé : Lettres d'humanité 50, no. 4 (1991): 401–13. http://dx.doi.org/10.3406/bude.1991.1766.
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Lyraud, Pierre, and Pierre Lyraud. "La manière de citer : les citations latines montaniennes dans les Pensées." Dix-septième siècle 287, no. 2 (2020): 255. http://dx.doi.org/10.3917/dss.202.0255.
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Jeanjean, Benoît. "Les allusions et citations latines dans Les Aventures d’Astérix le Gaulois." Anabases, no. 9 (March 1, 2009): 296–302. http://dx.doi.org/10.4000/anabases.537.
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Colombo Timelli, Maria. "Culture savante et culture 'populaire' chez Jean Wauquelin: citations latines et locutions proverbiales dans La Manequine en prose." Le Moyen Français 59 (January 2006): 7–22. http://dx.doi.org/10.1484/j.lmfr.2.303136.
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Padilla, Monica J., and Gregory Karczmar. "Abstract 1941: Barriers and effective interventions to engage Latinas' participation in breast cancer clinical trials." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1941. http://dx.doi.org/10.1158/1538-7445.am2023-1941.
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Abstract Breast cancer is the most diagnosed cancer among Latina women and is the leading cause of cancer-related death among Latinas (16.6%). While The Latino population is one of the fastest-growing populations in the US, they are severely underrepresented in clinical trials. Latinos make up 17% of the population but only 1% of clinical trial participants. Of clinical trials published covering 2001-2010, Latinos’ enrollment constituted only 2.2% of accrued participants. The percentage of Latino participants narrows down when we separate by gender. The goal of this study is to examine the prevalence of breast cancer-related barriers among Latinas and to determine the extent to which these barriers might influence Latinas enrolling in breast cancer clinical trials. If language and religion are the reason Latinas enroll less in breast cancer clinical trials, then increasing the availability of translated materials and a priest of a Catholic Church advertising the breast cancer studies will increase the enrollment rate of Latinas. Semi-constructed interviews were conducted with two Latino organizations to understand current barriers Latina’s face within the medical field. Based on these findings, I conducted an intervention at Our Lady of Tepeyac Church consisting of an information booth, making an announcement regarding Research Study 9127, and having bilingual Latinas available to give out more information while helping them enroll in Research Study 9127. At the end of the church intervention, 33 Latinas were enrolled in Research Study 9127, seeing a 550% increase in Latinas participating in Research Study 9127. Latinx women remain severely underrepresented in breast cancer clinical trials, thus limiting the generalizability of cancer clinical research, but interventions across churches would lead to improvements in general cancer knowledge, breast cancer screening practices, and intentions to enroll in clinical trials. This study can inform efforts to increase clinical trial participation in Latinas by highlighting important motivators to participation specific to Latinas and informing future interventions aimed at encouraging participation in clinical trials in a culturally sensitive and effective way. Citation Format: Monica J. Padilla, Gregory Karczmar. Barriers and effective interventions to engage Latinas' participation in breast cancer clinical trials [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1941.
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Fernandez, Alejandro, Mayra Serrano, Marisela Garcia, Katty Nerio, and Kimlin Ashing. "Abstract A22: Challenges using mobile technology for research participation in preventive health research: A preliminary investigation with Spanish-speaking Latinas." Cancer Epidemiology, Biomarkers & Prevention 29, no. 9_Supplement (September 1, 2020): A22. http://dx.doi.org/10.1158/1538-7755.modpop19-a22.
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Abstract Technology offers significant contributions to improve health care. However, less than half of foreign-born Latinos utilize data applications. The acceptability and application of these new communication and data harnessing tools can present both opportunities and challenges for some. We report our observations of the challenges Latinas face using mobile technology. Latina mothers were recruited from a pilot diabetes risk reduction program. A total of 32 mothers participated in the program; 63% were Spanish speakers, 59% were foreign-born, 66% had ≤high school education, and 91% reported income <$40,000. Participants used a mobile device to perform two tasks: 1) complete an online survey on a tablet and 2) download and install a fitness tracker mobile application. Mothers rated their confidence in their ability to use mobile technology using a 4-point Likert scale. Participants with little/no confidence requested paper versions of the survey. Most mothers required staff assistance to complete the survey and set up their fitness tracker. Spanish-speaking mothers were more likely to report little/no confidence connecting to Wi-Fi (χ2=13.175, p<0.01), downloading an app (χ2=11.277, p=0.01), and creating an electronic account (χ2=7.882, p<0.05). Although participants were smartphone users, the majority needed dedicated, individual assistance to complete the tasks (e.g., survey and app). Growing evidence suggests that Latinos have the capacity to use mobile technology to increase healthy behaviors. Our findings suggest that lower-income Spanish speakers require more assistance with technology for research data collection. Studies and programs using mobile technology should account for the added staffing and resources required to conduct studies with this population. Citation Format: Alejandro Fernandez, Mayra Serrano, Marisela Garcia, Katty Nerio, Kimlin Ashing. Challenges using mobile technology for research participation in preventive health research: A preliminary investigation with Spanish-speaking Latinas [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr A22.
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Armenta, Amada. "Racializing Crimmigration." Sociology of Race and Ethnicity 3, no. 1 (July 8, 2016): 82–95. http://dx.doi.org/10.1177/2332649216648714.
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Deporting “criminal aliens” has become the highest priority in American immigration enforcement. Today, most deportations are achieved through the “crimmigration” system, a term that describes the convergence of the criminal justice and immigration enforcement systems. Emerging research argues that U.S. immigration enforcement is a “racial project” that subordinates and racializes Latino residents in the United States. This article examines the role of local law enforcement agencies in the racialization process by focusing on the techniques and logics that drive law enforcement practices across two agencies, I argue that local law enforcement agents racialize Latinos by punishing illegality through their daily, and sometimes mundane, practices. Investigatory traffic stops put Latinos at disproportionate risk of arrest and citation, and processing at the local jail subjects unauthorized immigrants to deportation. Although a variety of local actors sustain the deportation system, most do not see themselves as active participants in immigrant removal and they explain their behavior through a colorblind ideology. This colorblind ideology obscures and naturalizes how organizational practices and laws converge to systematically criminalize and punish Latinos in the United States.
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Ridley-Merriweather, Katherine E., and Katherine Vogel. "Abstract B033: Understanding Latinas’ decisions to participate in a unique breast cancer clinical trial: A qualitative constructivist grounded theory study." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B033. http://dx.doi.org/10.1158/1538-7755.disp24-b033.
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Abstract Background & Objective: Breast cancer is the most common cause of cancer death in Latinas in the United States; however, researchers often fail to use recruitment messaging targeted toward increasing Latina participation. Although the cancer disparities observed among this population are significant, these group members account for only 1.3% of cancer-related clinical trial participants in the United States. The barriers preventing Latinas’ participation in research are well-established, but there are few studies focused on comprehending the motivations of Latinas who previously volunteered for clinical trial participation. The aims of this study were to improve the understanding of Latinas’ decisions to participate in a unique breast cancer clinical trial and to propose future methods for increasing these group members’ motivations regarding medical research participation. Methods: Guided by constructivist grounded theory, twenty women (N= 20) who self-identified as Latina or Hispanic, and who had previously donated healthy breast tissue to a biobank that was part of a clinical trial, were interviewed regarding their medical research participation decisions. Participants were recruited through direct email and interviews were conducted over Zoom and Microsoft Teams. Results: Findings revealed three primary themes: (1) the availability of both bilingual recruitment materials and research team personnel were viewed as important motivators to participate, (2) the knowledge of their underrepresentation in medical research and the understanding that their participation may help Latinas in the future were revealed as important motivators to participate, and (3) individuals who received negative feedback from family and/or friends about their intended research participation remained resolute in their decision to donate tissue. Conclusions: Understanding the motivations of Latinas who have previously participated in cancer-related clinical trials can help researchers create targeted and/or tailored recruitment messaging. Messaging must emphasize the consequences of underrepresentation of Latinas in clinical trials, be bilingual, and communicate that participation in cancer clinical trials can positively impact the health of other Latinas in the future. Citation Format: Katherine E. Ridley-Merriweather, Katherine Vogel. Understanding Latinas’ decisions to participate in a unique breast cancer clinical trial: A qualitative constructivist grounded theory study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B033.
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Westra, Haijo. "Références classiques implicites et explicites dans les écrits des Jésuites surla Nouvelle-France 1." Tangence, no. 92 (November 24, 2010): 27–37. http://dx.doi.org/10.7202/044940ar.
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Cet article s’intéresse à la pratique de la citation implicite des sourcesclassiques dans les écrits latins des Jésuites sur le Canada, que l’on compare aveccelle de la citation explicite, en usage chez les mêmes auteurs dans les Relations qui, elles, sont écrites en languevernaculaire. L’analyse d’un poème latin figurant en tête du Journal des Jésuites permettra d’illustrer lepropos, en montrant en quoi l’inspiration virgilienne dont il procède met enparallèle la situation désastreuse de la mission jésuite en Nouvelle-France vers1650 avec celle des Troyens exilés dans l’Énéide de Virgile. Ce poème, dont la signification n’a pas étéreconnue jusqu’à ce jour, témoigne d’une sensibilité se démarquant tout-à-fait decelle qui s’exprime dans les Relations.
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Vanhulst, Julien, and Edwin Zaccai. "Le paysage intellectuel du développement durable en Amérique latine. Une analyse de réseau à partir des citations d’auteurs latino-américains." Natures Sciences Sociétés 27, no. 3 (July 2019): 278–96. http://dx.doi.org/10.1051/nss/2019045.
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Les discours scientifiques sont influencés par des visions du monde et des valeurs partagées par des communautés scientifiques. En matière de développement durable, comme pour d’autres sujets, la production, diffusion et réception de savoirs structurent l’univers discursif d’espaces académiques. Cet article propose une cartographie du champ des interactions académiques d’un échantillon de 93 intellectuels influents en matière de développement durable en Amérique latine à partir d’un examen de plus de dix mille citations sur une période de quarante ans (1972-2012). Cette analyse quantitative est complétée par une analyse qualitative portant sur le contenu de la pensée des auteurs les plus importants. Il en ressort une structuration progressive du champ discursif sur le sous-continent. Sur le fond, nous observons que beaucoup de discours académiques, construits en synergie avec certains mouvements sociaux qui luttent pour la justice et la soutenabilité socioenvironnementale, s’avèrent critiques.
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Arana-Chicas, Evelyn, Francisco Cartujano-Barrera, Xueya Cai, Shan Gao, Lisa S. Cox, and Ana P. Cupertino. "Abstract B001: Biopsychosocial correlates of smoking menthol cigarettes and cessation among Latino smokers." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B001. http://dx.doi.org/10.1158/1538-7755.disp22-b001.
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Abstract Introduction: Smoking menthol cigarettes is more prevalent among Latinos compared to non-Latino Whites. Latinos who smoke menthol are less likely to quit than Latinos who do not smoke menthol. However, there is scant information on the biopsychosocial factors correlated with smoking menthol among Latinos. Objective: To assess the biopsychosocial correlates of smoking menthol cigarettes and whether smoking menthol is associated with cessation among Latino smokers. Methods: This secondary analysis utilized baseline data from the Decídetexto study, an mhealth smoking cessation randomized clinical trial for Latinos. Participants resided in the United States and originated from the U.S. and 20 Latin American countries. Biopsychosocial variables included body mass index, # of comorbidities, age, alcohol use, depression, anxiety, self-efficacy, education, health insurance, household income, marital status, country of origin, and acculturation – years in the U.S., primary language, and generation, and smoking cessation. Chi-square tests and one-way ANOVAs were employed. Logistic regression models were performed to test the association between menthol use and smoking cessation, when treatment arm and other demographic variables were controlled. Results: Participants’ (n=457) mean age was 48.7 (SD=11.1), most were female (54.7%), primarily Spanish speakers (70.5%), daily smokers (91.7%), married (53.6%), and had an annual income between 0 – 29K (42.7%). Almost half of participants currently smoke menthol cigarettes (48.8%) and mean daily cigarettes was 11.6 (SD=8.03). Use of menthol was associated positively with younger age (46.3 vs 51.0 years; p<.001), having health insurance (53.6% vs 38.7%; p=0.004), unemployment (57.1% vs 44.6%, p=0.013), living longer years in the U.S. (31.0 vs 27.5 years; p=0.026), being 2nd generation in the U.S. compared to 1st generation (73.1% vs 41.7%; p<.001), and speaking primarily English (63.0% vs 42.9%, p<.001). Moreover, Puerto Ricans had significantly higher usage of menthol cigarettes compared to Latinos from other Latin American countries (75.7% vs 38.8%; p<.001). There were no significant correlations between psychological and biological variables and smoking menthol cigarettes. When looking at self-reported and biochemically verified cessation rates, Latinos who smoke menthol had lower quit rates (26.5% and 10.7% abstinent, respectively) compared to Latinos who do not smoke menthol (28.2% and 12.8% abstinent, respectively) (OR=1.05; 95% CI=0.65, 1.69; p=0.84 and OR=0.89; 95% CI=0.47, 1.68; p=0.71, respectively), although not statistically significant. Conclusion: Latinos who are more acculturated and from lower socioeconomic status were more likely to smoke menthol. The higher rates of continued smoking among menthol users is clinically meaningful and suggests menthol use may mark the need for additional support for successful quitting. These results are particularly relevant for Puerto Rican smokers who are more likely to smoke and use menthol cigarettes compared to other Latino subgroups. Citation Format: Evelyn Arana-Chicas, Francisco Cartujano-Barrera, Xueya Cai, Shan Gao, Lisa S. Cox, Ana P. Cupertino. Biopsychosocial correlates of smoking menthol cigarettes and cessation among Latino smokers [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B001.
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Niu, Zhaomeng, Aarthi Shanmugavel, Yonaira Rivera, Carolina Lozada, Emily Peters, and Carolyn Heckman. "Abstract A009: Engaging Latino communities to develop a skin cancer intervention: A qualitative exploration." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (December 1, 2023): A009. http://dx.doi.org/10.1158/1538-7755.disp23-a009.
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Abstract Introduction: In the past two decades, melanoma (the deadliest form of skin cancer) incidence among Latinos has risen by 20%. Despite the lower incidence rate of skin cancers among Latinos compared to Caucasians, the mortality rate of Latinos is higher. However, skin cancer is understudied among Latinos and they were less likely to engage in skin cancer preventive behaviors. This qualitative study explored Latinos’ beliefs and behaviors related to skin cancer and their interest in a skin cancer intervention from both community members and key stakeholders. Methods: Latinos were recruited in New Jersey through community organizations and social media posts (n=34; 11 Spanish-preferring and 23 English-preferring) for focus group discussions. Five focus groups (2 in Spanish and 3 in English) were conducted, where participants discussed their perceptions and behaviors about skin cancer, sun protection, skin self-examination, culture and lifestyles, and their recommendations for a mobile skin cancer intervention. Additionally, healthcare providers (n=4) and Latino community leaders (n=5) were recruited for individual interviews to complement the results of focus groups. A thematic analysis was conducted on all transcripts. Results: Focus group participants aged from 18 to 73 (M=33.44), 50% were female (n=17), 29.4% (n=10) had a household income below $25000, and 32.3% (n=11) had less than a college degree. Awareness of and knowledge about skin cancer, sun protection, and skin examination were low overall. All participants indicated that skin cancer communication is rare among Latinos. There was consensus among the findings of the focus groups and key stakeholder interviews. Perceived barriers included: 1) limited access (e.g., health insurance); 2) low awareness or knowledge (e.g., don’t know efficient sun protection methods or what to look for in skin self-examination); 3) misperception (e.g., dark skin won’t get skin cancer). Salient facilitators included: 1) care for family (e.g., sunscreen for children and parents); 2) consequences (e.g., worry and fear of aging or death, sunburns); 3) coverage or access (e.g., good insurance). Social media usage was prevalent in many households, with WhatsApp and Facebook being popular platforms for communication with family and friends, as well as for discussing health-related topics. The consensus regarding intervention messages was that visuals and clear/simple messages featuring Latinos would be effective in educating about skin cancer and promoting behavior change. As complementary findings, key stakeholders indicated that educating the women in the family on sun safety behaviors, involving local Latino organizations, and delivering messages from physicians directly would be effective. Conclusions: Findings highlight the importance of skin cancer education within the Latino community, particularly due to low awareness and misperception of skin cancer, sun protection, and skin examination. Social media present a promising way to reach Latinos through culturally-centered and mobile-based interventions. Citation Format: Zhaomeng Niu, Aarthi Shanmugavel, Yonaira Rivera, Carolina Lozada, Emily Peters, Carolyn Heckman. Engaging Latino communities to develop a skin cancer intervention: A qualitative exploration [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A009.
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Lewis, Jessica, Amy Smoyer, Erin Singleton, Marcella Nunez-Smith, Imran Saeed, and Patricia LoRusso. "Abstract B123: Multilevel influences on Black and Hispanic/Latine patient participation in early phase cancer clinical trials." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B123. http://dx.doi.org/10.1158/1538-7755.disp24-b123.
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Abstract Black and Hispanic/Latine patients are disproportionately burdened by cancer yet underrepresented in cancer clinical trials. Diverse participation in cancer clinical trials is essential to identify potential group differences in risks and benefits and to ensure equitable access to cutting-edge therapeutics. Prior research has focused on barriers to representation in later phase trials with less focus on early phase cancer clinical trials (EPCCTs). EPCCTs may include unique barriers to representation based on safety focus and intensive monitoring. We investigate multi-level influences on EPCCT participation for Black and Hispanic/Latine patients through in-depth qualitative interviews with (n=30) Black or Hispanic/Latine metastatic cancer patients and (n=30) oncology providers/staff from two community practices. Using the Ecological Model as a guiding framework, we explored facilitators and barriers to diverse EPCCT participation at the patient level, provider level, health system/policy level, and community level. We utilized Rapid Qualitative Inquiry to gain pragmatic, accurate understanding. At the patient level, we identified informational (e.g., understanding of cancer), emotional (e.g., trust), and instrumental (e.g., transportation) influences on Black and Hispanic/Latine participation. The most pervasive barrier to EPCCT inclusion was lack of invitation for Black and Hispanic/Latine patients. At the provider/staff level, key barriers to representation included low EPCCT knowledge among providers, preconceptions about barriers for Black and Hispanic/Latine patients, and perceived loss of control/relationship with patients/caregivers. At the health system/policy level, critical barriers included insufficient time to discuss EPCCTs, concerns about impact of trials on systems (e.g., wait-time for scans), and provider discomfort with referral process (sending patients to Phase I team without specific trial knowledge). At the community level, salient influences on patient decision-making were identified (e.g., peers, youtube). We conducted a systemwide survey of (n=81) oncology providers and their attitudes, beliefs, and behaviors regarding EPCCTs; we determined how attitudes and beliefs related to EPCCT referral behaviors. We have planned interventions to mitigate each barrier and leverage each facilitator to increase representation. It is critical to identify and address relevant local barriers to ensure equitable access to novel therapeutics and generalizability of scientific discoveries. Citation Format: Jessica Lewis, Amy Smoyer, Erin Singleton, Marcella Nunez-Smith, Imran Saeed, Patricia LoRusso. Multilevel influences on Black and Hispanic/Latine patient participation in early phase cancer clinical trials [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B123.
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Samayoa, Cathy, Erick Olivares, Catherine Gavile, and Adriana Visbal. "Abstract B062: Prevalence of pathogenic BRCA1/2 variants among Latinas in the All of Us Cohort." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (December 1, 2023): B062. http://dx.doi.org/10.1158/1538-7755.disp23-b062.
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Abstract Latinas in the United States are disproportionately affected by breast cancer, but little is known about genetic risk factors for breast cancer in this population. Genetic variants in BReast CAncer genes 1 and 2 (BRCA1/2) are known to be associated with heritable cancer risk, yet the prevalence of BRCA1/2 pathogenic variants in the Latina population is not well characterized. This study aims to examine the prevalence of pathogenic BRCA1/2 variants among Latinas in the NIH All of Us research program, which includes a large number of individuals representative of the diversity of the United States population. Using data from the All of Us research program, we will analyze the prevalence of these variants among Latinas, in addition to all other racial and ethnic groups. To date, the All of Us cohort contains 245,400 genomes, and of those 41,940 (17%) are from self-identified Hispanic/Latino/or Spanish participants. We will compare the prevalence of pathogenic, or likely pathogenic, variants across self-reported race/ethnicity and continental genetic ancestry categories. Our study will leverage the diversity of All of Us and enable us to compare our data with those from more Eurocentric databases. With these data, we can potentially 1) identify novel variants that could predispose to increased cancer risk; and 2) clarify the previous designations of variants characterized to have undetermined/unknown significance due to the limitations of using a single Eurocentric reference genome. Identifying the actual prevalence of pathogenic BRCA1/2 variants among Latinas is important for improving breast cancer prevention, detection, and treatment in this population. The findings of this study have the potential to inform genetic counseling and testing recommendations for Latina patients at high risk of developing breast cancer, as well as others. This will also enable healthcare providers to better understand the unique genetic factors contributing to breast cancer risk among this population. Ultimately, this knowledge can improve the care of Latina patients and contribute to the broader effort to advance health equity and reduce disparities in breast cancer outcomes among Latinas. Citation Format: Cathy Samayoa, Erick Olivares, Catherine Gavile, Adriana Visbal. Prevalence of pathogenic BRCA1/2 variants among Latinas in the All of Us Cohort [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B062.
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Montoya, Dennis J., Ana Estrada-Florez, Paul Lott, Katherine Chiu, John Suarez-Olaya, Fabian Castro, Magdalena Echeverry de Polanco, Javier Torres, Mabel Bohorquez, and Luis Carvajal-Carmona. "Abstract C095: Molecular characterization of gastric adenocarcinoma from Latinos shows homologous recombination deficiency." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): C095. http://dx.doi.org/10.1158/1538-7755.disp24-c095.
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Abstract Latinos have a higher risk of developing gastric cancer (GC) than non-Latino Whites (NLW). Multiple studies have shown increased treatment resistance in diffuse-type cancers, which are more prevalent in Latino patients and dominated by the genomically stable (GS) genomic subtype. However, there is little genomic data from Latino gastric tumors due to the few studies targeting this minority population. Here, we attempt to rectify the disparity of genomic data by performing whole exome and/or low-coverage whole genome sequencing on tumors from 195 Latino gastric adenocarcinoma patients, from Colombia and Mexico. We also analyze 42 Latino patients from the US from a previous study. In total, we analyze tumors from 237 patients, the largest cohort of Latino gastric cancer tumors comprehensively sequenced thus far. Molecular subtyping of our cohort shows a higher proportion of tumors with a genomically stable (GS) subtype, 59%, and less with chromosomal instability (CIN), 24%, than reported in non-Latino patients from the Cancer Genome Atlas (20% and 50% respectively). Our earlier study of germline variants from Latinos, indicated a potential enrichment of variant related to homologous recombination deficiency (HRD), an important DNA repair mechanism. Focusing on this pathway, we performed HRD scoring and show that CIN tumors had the highest HRD score compared to all other subtypes. An alternative method analyzing somatic mutational patterns identified an indel mutational signature (ID6), also related to HRD, was enriched in GS tumors. Overall, these data provide a broader picture of the genomic landscape of Hispanic tumors, highlighting HRD targeting drugs as a potential treatment for both GS diffuse-types cancers particularly seen in Latinos and CIN tumors found more generally in gastric cancer. Citation Format: Dennis J Montoya, Ana Estrada-Florez, Paul Lott, Katherine Chiu, John Suarez-Olaya, Fabian Castro, Magdalena Echeverry de Polanco, Javier Torres, Mabel Bohorquez, Luis Carvajal-Carmona. Molecular characterization of gastric adenocarcinoma from Latinos shows homologous recombination deficiency [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C095.
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Ramírez León, Dayanna A., Lauren E. Barber, Sheryl Gabram-Mendola, Cindy Snyder, Susan Vadaparampil, Lindsay Fuzzell, Lauren E. McCullough, Lynn Durham, and Yue Guan. "Abstract A147: A ten-year overview of cancer genetic family history screening in Georgia’s Latina population." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): A147. http://dx.doi.org/10.1158/1538-7755.disp24-a147.
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Abstract Introduction: Population-based cancer genetic family history screening to identify families at high risk for BRCA-associated cancers has been endorsed by national public health policies. This report aimed to describe the utilization of family history screening services from 2013 to 2022 according to rurality and socioeconomic deprivation among the Latina community in the state of Georgia. Methods: Self-identified Latina women who attended a medical appointment at participating Georgia Public Health Clinics were invited to utilize the cancer genetic family history screening services. Screening results and participant zip code were reviewed. Area deprivation index (ADI) was measured at the census block group level and assessed as a dichotomous variable (more deprived and less deprived). Rurality was measured through Rural-Urban Commuting Area (RUCA) codes and was assessed dichotomously (urban and rural). The ADI and RUCA codes were linked to participant data by zip code to characterize genetic service access among the Latina community. Results: We found 9,330 (3.31%) adult Latinas in Georgia completed cancer genetic family history screening from 2013-2022. In this sample, 9,066 (97.17%) women screened negative, and 264 (2.83%) women screened positive (i.e., family history suggestive of higher risk for carrying BRCA1/2 mutations compared to the general population). The family history screening program reached Latinas in 16 of 18 public health districts in Georgia. However, family history screening completion varied significantly across the 16 districts (mean=327 women, range: 2 - 1,337). FH screening completion was higher among Latinas in urban areas (n=7,871) than Latinas in rural areas (n=1,459). Latinas who lived in more socially deprived areas appeared to have a higher number of screening completion (n=5,207) than those living in less socially deprived areas (n=4,123) due to interaction with urbanicity. Conclusions: Georgia’s family history screening program was able to reach Latina women across the state of Georgia, particularly those living in urban, socially deprived areas. To ensure equitable cancer genetic screening dissemination, future efforts should prioritize tailored outreach in rural regions and a comprehensive evaluation to identify key determinants of screening trends among Georgia’s Latina population. Citation Format: Dayanna A. Ramírez León, Lauren E. Barber, Sheryl Gabram-Mendola, Cindy Snyder, Susan Vadaparampil, Lindsay Fuzzell, Lauren E. McCullough, Lynn Durham, Yue Guan. A ten-year overview of cancer genetic family history screening in Georgia’s Latina population [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A147.
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Lafleur, Claude, and Joanne Carrier. "Logique et (triple) logos dans la Divisio scientiarum d’Arnoul de Provence." Articles spéciaux 73, no. 3 (April 11, 2018): 415–36. http://dx.doi.org/10.7202/1044569ar.
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Le but de cet article est d’abord d’enrichir l’exposé sur l’apport des magistri artium dans Le Discours intérieur de Claude Panaccio par l’examen approfondi d’une citation de l’al-Fārābī latin clôturant la présentation de la logique dans la Divisio scientiarum (vers 1250) du maître ès arts de Paris Arnoul de Provence (Arnulfus Provincialis). Ensuite, cet examen accompli à l’aide des diverses versions ou adaptations latines de l’Énumération des sciences (Iḥṣāʾ al-ʿulūm) farabienne (par Gérard de Crémone et Gundissalinus), il ressort que, malgré une certaine dualité dans sa tradition manuscrite, le passage concerné de la Division des sciences d’Arnoul de Provence ne se borne pas à distinguer logos intérieur et logos extérieur, mais considère aussi, comme sa source, un troisième logos, et cela d’une manière susceptible d’affiner la caractérisation de la triade du logos chez al-Fārābī telle qu’en rend compte Le Discours intérieur dans son judicieux rapprochement avec une doctrine parallèle chez Jean Damascène (Ekdosis akribès tès orthodoxou pisteôs ou De fide orthodoxa) interprétée autrement par Thomas d’Aquin à la suite d’Albert le Grand.
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Kapoor, Pooja Middha, Angel C. Mak, Linda Kachuri, Donglei Hu, Scott Huntsman, Lawrence H. Kushi, Christopher Haiman, et al. "Abstract 3631: Transcriptome-wide association study identifies novel genes associated with breast cancer susceptibility in Latinas." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3631. http://dx.doi.org/10.1158/1538-7445.am2022-3631.
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Abstract Background: Genetic susceptibility to breast cancer has been studied extensively in European ancestry populations, but few studies have addressed genetic susceptibility in non-European women. Latinas are a genetically diverse group with contributions from European, African, and Indigenous American ancestries. Genome-wide association studies (GWAS) have identified unique variants in this population, particularly at the 6q25 locus. We conducted a transcriptome-wide association study (TWAS) to identify novel genes associated with risk of breast cancer in Latinas. Methods: We used individual level GWAS data from 2,396 Latina cases and 6,505 Latina controls from the studies in Northern California (San Francisco Bay Area Breast Cancer Study, Northern California Breast Cancer Family Registry and Kaiser Permanente Genetic Epidemiology Research on Aging Cohort), Southern California (Multi-ethnic Cohort) and Mexico (CAMA study). We analyzed the association between genetically predicted whole blood (WB) gene expression and breast cancer risk using newly developed TWAS models based on 784 Mexican American individuals. We also conducted parallel analyses using breast mammary tissue (BT) TWAS models from GTEx v8. All analyses were adjusted for age, ancestry, and study. Associations with false discovery rate (FDR) probability <0.05 were considered statistically significant. Results: At FDR<0.05, we identified 20 genes from BT and 39 genes from WB. Seven of the genes were significantly associated in both the WB models and GTEx BT models. Increased expression of MIB2 (pFDR = 4.74x10-17 (WB) and 1.22x10-4 (BT)), NBPF26 (pFDR = 1.30x10-7 (WB) and 7.43x10-8 (BT)), SLC35E2B (pFDR = 1.12x10-4 (WB) and 5.47x10-5 (BT)), and FAM30A (pFDR = 1.18x10-10 (WB) and 9.27x10-3 (BT)) was associated with increased risk of breast cancer risk, whereas increased expression of SLC35E2A (pFDR = 8.17x10-6 (WB) and 1.55x10-3 (BT)) and HCP5B (pFDR = 1.84x10-3 (WB) and 2.19x10-3 (BT)) was associated with decreased breast cancer risk. Increased expression of PDGFA was associated with increased risk (pFDR = 1.30x10-7) in GTEx BT reference models but decreased risk (pFDR = 2.34x10-10) in the ancestry-specific WB model. Conclusion: Our study is the first TWAS investigating the relationship between genetically predicted gene expression and breast cancer risk in Latinas. By leveraging gene expression prediction models that capture eQTLs that are more common in populations with Indigenous American ancestry, we have identified some novel genes associated with breast cancer risk in Latinas. Of these, MIB2 is a strong candidate for a mechanistic role in breast carcinogenesis in Latinas. MIB2 is involved in Notch signaling which plays an important role in breast carcinogenesis via its mismatched receptor-ligand interaction. Our study highlights the role of ancestry-based prediction models in TWAS analyses. Citation Format: Pooja Middha Kapoor, Angel C. Mak, Linda Kachuri, Donglei Hu, Scott Huntsman, Lawrence H. Kushi, Christopher Haiman, Esther M. John, Gabriela Torres-Mejia, Esteban G. Burchard, Susan L. Neuhausen, Laura Fejerman, Elad Ziv. Transcriptome-wide association study identifies novel genes associated with breast cancer susceptibility in Latinas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3631.
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Furno, Martine. "À l’aube de la bibliographie : les références externes dans les dictionnaires latins, 1480–1545." Renaissance and Reformation 34, no. 3 (July 26, 2012): 47–63. http://dx.doi.org/10.33137/rr.v34i3.17020.
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The appearance of printed text resulted in changes to the way text is accessed, which leads to the question of whether these changes modified scholarly practice; and if so, how? The following article examines this question in a particular context—that of dictionaries and encyclopedias, referencing classical citations as guarantors and examples. The article defines the evolution of three important witnesses in this domain from the end of the fifteenth century to the first part of the sixteenth: the Cornu Copiæ by Niccolo Perotti, the Commentarii linguae latinæ by Etienne Dolet, of which two tomes appeared in 1536 and 1538, and the Thesaurus Latinae Linguae by Robert Estienne, in its three versions from 1531, 1536, and 1543. These three books represent the same type of object: language dictionaries, aimed towards a specific public of advanced learners, or the learned. In fact, the material weight of book fabrication, the difficulty from then on of collecting masses of texts, the new study conditions, the sheer quantity of texts available, and the famous temptation of universality, made the practice of regulation and of precise referencing an urgent necessity. The position of learned printers of Estienne’s generation was crucial: they helped create and then make commonplace certain material norms that are now so much part of our intellectual habit that we sometimes forget their material origin.
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Parada, Humberto, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F. Olshan, Kelly R. Evenson, Thomas E. Rohan, Robert C. Kaplan, et al. "Abstract A078: Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): A078. http://dx.doi.org/10.1158/1538-7755.disp24-a078.
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Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR015) of the Conference Program/Proceedings. Citation Format: Humberto Parada, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F. Olshan, Kelly R. Evenson, Thomas E. Rohan, Robert C. Kaplan, Caroline A. Thompson, Linda C. Gallo, Frank J. Penedo, Jianwen Cai, Sylvia Wassertheil-Smoller, Bharat Thyagarajan, Stefani N. Thomas, Olga L. Garcia-Bedoya, Gregory A. Talavera. Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A078.
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Wu, Lang, Xiequn Xu, Dalia Ghoneim, Kayla Kim, Alexandra Binder, Yesha Patel, Daniel O. Stram, Loïc Le Marchand, and Sungshim L. Park. "Abstract 5705: Identifying DNA methylation quantitative trait loci across multi-ethnic populations." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5705. http://dx.doi.org/10.1158/1538-7445.am2022-5705.
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Abstract Objective: To date, genome-wide association studies (GWAS), which are primarily conducted in Europeans, have identified a large number of validated DNA methylation quantitative trait loci (meQTLs) acting in both cis and trans. However, it is recognized that there are racial differences in genetic architectures such as allele frequencies and linkage equilibrium patterns, which may differentially influence DNA methylation levels. This points to a critical need to conduct a methylome wide association study (MWAS) to identify meQTLs across multiethnic populations including understudied African Americans (AAs), Latinos, Japanese Americans (JAs), and Native Hawaiians (NHs). Methods: We are performing a GWAS to identify meQTLs in blood leukocytes in a multiethnic population using data from the Multiethnic Cohort Study (MEC). In MEC, “genome-wide” germline genetic variants and DNA methylation levels of blood leukocytes have been measured using the Illumina 1M and MethEPIC array, respectively, for 372 AAs, 408 Latinos, 531 JAs, 319 NHs, and 406 European Americans who were current smokers at time of blood draw. Genotyped data has been imputed with 1000 Genomes phase 3 dataset. For DNA methylation data, standardized quality control (QC) and normalization have been performed. We adjusted for the following potential confounders at time of blood draw: age, sex, body mass index, estimated cell type composition variables, genetic principal components, smoking pack-years, and urinary total nicotine equivalents (a biomarker for internal smoking dose). A stringent Bonferroni-corrected threshold (P<5×10-8/(850,355×6) = 9.80×10-15) was used to define statistical significance. An independent dataset of MEC participants including 114 AAs, 142 Latinos, 286 JAs, 108 NHs, and 270 European Americans will be used to replicate the identified meQTLs. Results: Our preliminary analyses for identifying cis-meQTL SNPs (residing within 1 Mb upstream or downstream of a CpG site of interest) found 169,823 CpG sites (20.0%) are associated with at least one nearby genetic variant in AAs. Similarly, 284,371 CpG sites (33.4%) in JAs, 168,580 CpG sites (19.8%) in Latinos, 123,032 CpG sites (14.5%) in NHs, and 234,822 CpG sites (27.6%) in European Americans are significantly associated with at least one nearby genetic variant. In the pan-ethnic analyses including all five ethnic/racial groups, 193,743 CpG sites (23.0%) are associated with at least one nearby genetic variant. Conclusion: Our preliminary findings identified ethnic-specific and pan-ethnic cis-meQTL SNPs across a multiethnic population that includes understudied AAs, Latinos, JAs, NHs, along with European Americans. If replicated in independent datasets, these findings will significantly improve our understanding of genetic regulation of DNA methylation levels in these populations. Citation Format: Lang Wu, Xiequn Xu, Dalia Ghoneim, Kayla Kim, Alexandra Binder, Yesha Patel, Daniel O. Stram, Loïc Le Marchand, Sungshim L. Park. Identifying DNA methylation quantitative trait loci across multi-ethnic populations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5705.
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Rivera-Peña, BIanca, Oluwasina Folawiyo, Nitesh Turaga, Rosa J. Rodríguez-Benítez, Marco E. Felici, Jaime A. Aponte-Ortiz, Francesca Pirini, et al. "Abstract 5765: Promoter DNA methylation patterns in oral, laryngeal, and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement, and survival in Latinos." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5765. http://dx.doi.org/10.1158/1538-7445.am2023-5765.
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Abstract Hispanics/Latinos, Black Americans, and poor Non-Latino Whites in the United States are at higher risk of developing head and neck squamous cell carcinoma (HNSCC). The incidence of HNSCC in Puerto Rico is 2.5 higher than for Hispanics/Latinos living in the United States. These health disparities are a serious public health concern due to HNSCC high mortality and morbidity rates, higher treatment costs, and significant quality of life burden. We hypothesized that the discovery of actionable targets for HNSCC early detection, diagnosis, prognostication. Differentially Methylated Regions (DMRs) can be used as HNSCC diagnostic, prognostic, and therapeutic targets in precision medicine workflows. DNA from 23 HNSCC samples and 10 healthy oral tissue samples from patients in Puerto Rico were hybridized to a genome-wide tiling array to identify DMRs in a discovery cohort. Downstream analyses identified differences in promoter DNA methylation patterns in oral, laryngeal, and oropharyngeal anatomical regions associated with tumor differentiation, nodal involvement, and survival. Genome-wide DMR analysis showed 2,565 DMRs common to the three subsites. We identified 738 DMRs unique to laryngeal cancer (n=7), 889 DMRs unique to oral cavity cancer (n=10), and 363 DMRs unique to pharyngeal cancer (n=6). Based on the genome-wide analysis, and a gene ontology analysis, we selected 10 candidate genes to test for prognostic value and association with clinicopathological features. TIMP3 was associated with tumor differentiation in oral cavity cancer (p =0.039), DAPK1 was associated with nodal involvement in pharyngeal cancer (p = 0.017), and PAX1 was associated with tumor differentiation in laryngeal cancer (p = 0.040). We selected 5 candidate genes, DAPK1, CDH1, PAX1, CALCA, and TIMP3, for a prevalence study in a larger validation cohort: 42 oral cavity; 25 pharyngeal; and 52 laryngeal cancer samples. PAX1 hypermethylation differed across HNSCC anatomic sub-sites (p= 0.029), and predominantly detected in laryngeal cancer. Kaplan-Meier survival analysis (p=0.043) and Cox regression analysis of overall survival (p=0.001) showed that DAPK1 methylation is associated with better prognosis in HNSCC. Our findings show that HNSCC sub-sites (oral cavity, pharynx, and larynx) display substantial differences in aberrant DNA methylation patterns among Hispanic/Latinos HNSCC patients in the US. These data suggest further research may lead to the development of diagnostic medical devices, prognostic biomarkers and novel therapeutic targets that may lead to a reduction in HNSCC disparities among Hispanic/Latinos in the US. Citation Format: BIanca Rivera-Peña, Oluwasina Folawiyo, Nitesh Turaga, Rosa J. Rodríguez-Benítez, Marco E. Felici, Jaime A. Aponte-Ortiz, Francesca Pirini, Sebastián Rodríguez-Torres, Roger Vázquez, Ricardo López, David Sidransky, Rafael E. Guerrero-Preston, Adriana Báez. Promoter DNA methylation patterns in oral, laryngeal, and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement, and survival in Latinos. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5765.
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Torres, Paola, Carolina Bujanda, Celeste Charchalac-Zapeta, Juanita Arroyo, Pamela Ganschow, Vivian Pan, Nathan Stackhouse, Sage J. Kim, Araceli Lucio, and Yamilé Molina. "Abstract A025: Empowering Latinas to obtain genetic services: Comparing precision cancer prevention strategies." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (December 1, 2023): A025. http://dx.doi.org/10.1158/1538-7755.disp23-a025.
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Abstract Purpose: Precision cancer prevention strategies are critical for addressing the complex interplay of adverse social determinants of health (SDOH) and elevated biological risks for breast cancer (BC) among Latinas and other marginalized communities. FQHC-community-academic partnerships may have particularly high potential for operationalizing these strategies and reducing population-level disparities through enhancing genetic counseling and testing (GCT) and subsequent cascade testing/personalized care. Objective: To present emerging results from a RCT comparing the effectiveness of two precision cancer prevention strategies on increasing GCT among Latinas and networks with elevated biological and adverse SDOH risks. Methods: Latinas Lideres en Salud (LaLiSa) is an ongoing RCT is situated in a 14-site federally qualified health center (FQHC) in Chicago. This unique FQHC has a comprehensive GCT program, as part of its integration with an academic medical center. Eligibility criteria for patients include: 1) identification as Latina, Hispanic, Chicana, etc.; 2) age of 18+ years old; 3) personal or family history of BC or related cancers (e.g., ovarian); 4) no previous GCT uptake; and, 5) no prior volunteerism. Patients are randomly assigned to participate in one of two 3-week phone-based interventions from a community agency. Both interventions offer personalized BC education, SDOH screening and navigation, and free/low-cost GCT services. “Educate” offers education on risk reduction (diet, exercise). “Empower” offers skills training on sharing precision cancer prevention information with family and other network members, who can also be eligible for SDOH navigation and GCT services. Data collection includes two surveys (baseline, post-intervention) for relevant covariates and use of study/navigation records for GCT uptake. Results: Of 299 patients approached, 89 participants have enrolled in the RCT (42 educate, 45 empower), with 89% retention. Approximately 55% are 50+ years old, 85% prefer Spanish, 65% have less than a high school education, and 64% have Medicaid/Medicare. For BC and SDOH risks, 17% are cancer survivors, 81% have financial stress and 42% have other competing SDOH risks (intimate partner violence, housing instability, transit instability). No significant arm differences exist. About 76% have initiated GCT referrals and 43% of participants have received GCT services, including 70% who have been identified as having elevated hereditary risk. Empower participants have been more likely to obtain GCT services than Educate participants, (51% vs. 33%, aOR = 5.44, 95%CI[1.45, 20.40], p=.01) after adjusting for age and self-reported social desirability. Discussion: Emerging data suggest the feasibility of precision cancer prevention strategies through FQHC-community-academic partnerships. Empower approaches may be more effective for enhancing at-risk Latinas’ GCT uptake than Educate approaches, when combined with SDOH navigation and free/low-cost GCT services. Limitations concern generalizability due a small, non-probability based sample. Citation Format: Paola Torres, Carolina Bujanda, Celeste Charchalac-Zapeta, Juanita Arroyo, Pamela Ganschow, Vivian Pan, Nathan Stackhouse, Sage J. Kim, Araceli Lucio, Yamilé Molina. Empowering Latinas to obtain genetic services: Comparing precision cancer prevention strategies [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A025.
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Tyson, Dinorah (Dina) Martinez, Melody Chavez, Gabriela Sanabria, Sejal Barden, Marangelie Velez, Erik Ruiz, and Brian Doss. "Abstract IA040: Promoting engagement of evidence-based interventions for Latinos: Cultural adaptation of an online intervention for Latina breast cancer survivors and their partners." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (December 1, 2023): IA040. http://dx.doi.org/10.1158/1538-7755.disp23-ia040.
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Abstract Although public health emphasizes the use of evidence-based interventions (EBIs), often they are not developed with diverse populations in mind, limiting engagement and cultural relevance. This presentation discusses the cultural adaptation of EBIs for Latinos using the adaptation of the online OurRelationship couple's intervention for Latina breast cancer survivors and their partners as a case example. The study used systematic, iterative, and community-engaged approaches, including formative research and patient-centered verification techniques, with ongoing feedback from the community advisory board. Adaptations went beyond translation, aiming for conceptual equivalence. The adapted program – Juntos Despues Del Cancer (JDC) - incorporated cancer-related stressors, coping techniques, social, cultural, and gender norms influencing couples' communication within the context of cancer survivorship. JDC maintained the integrity of OurRelationship while acknowledging the lived experience of Latino couples affected by breast cancer. Lessons learned include navigating fidelity versus fit tensions, focusing on conceptual translations, and recognizing Latino heterogeneity. The online nature of JDC allows for accessibility and nationwide availability. This cultural adaptation approach has broad applications, advancing public health practice and making EBIs more accessible to a diverse audience. Citation Format: Dinorah (Dina) Martinez Tyson, Melody Chavez, Gabriela Sanabria, Sejal Barden, Marangelie Velez, Erik Ruiz, Brian Doss. Promoting engagement of evidence-based interventions for Latinos: Cultural adaptation of an online intervention for Latina breast cancer survivors and their partners [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr IA040.
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Bogumil, David, Victoria Cortessis, Lynne Wilkens, Veronica Wendy Setiawan, Christopher Haiman, Loic Le Marchand, and Gertraud Maskarinec. "Abstract 734: History of diabetes is differentially associated with urothelial cancer risk in understudied racial/ethnic groups in the Multiethnic Cohort Study (MEC)." Cancer Research 82, no. 12_Supplement (June 15, 2022): 734. http://dx.doi.org/10.1158/1538-7445.am2022-734.
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Abstract Background: Type 2 diabetes (T2D) is an established risk factor for urothelial cancer (UC), however there is very little data characterizing this association in populations of non-European ancestry. Understanding the relationship between T2DM and UC across multiple populations is important since both risk and severity of each condition differ according to race and ethnicity. Methods: We estimated the association between T2D and UC among 185,587 MEC participants who were between 45 and 75 years old at enrollment (1993-1996) and from five major racial/ethnic groups (African Americans, Japanese Americans, Native Hawaiians, Latinos, and non-Hispanic whites). T2D status was assessed by self-report at cohort entry. UC cases were identified through linkages to statewide SEER cancer registries. We estimated the association between T2D and UC using Cox regression, adjusting for known confounders (smoking duration, smoking intensity, alcohol consumption, body mass index), stratifying on sex, age, and ethnicity. Using the full model, we assessed heterogeneity of associations by race/ethnicity. Results: Over a mean of 19 years of follow-up, 2,398 incident UC cases were identified. The prevalence of T2D was highest among African Americans (15.7%), followed by Latinos (15.6%), Native Hawaiians (14.8%), Japanese Americans (10.5%), and non-Hispanic whites (5.9%). The age-standardized UC incidence rates were highest among whites (60/100,000) followed by Japanese Americans (42/100,000), Native Hawaiians (40/100,000), African Americans (37/100,000), and Latinos (29/100,000). Incidence of UC was 1.11 (95% CI: 0.97, 1.26)-fold greater in those who reported a history of T2D, and this association differed between racial-ethnic groups (pheterogeneity=0.04). Estimates of the association between T2D and UC achieved statistical significance among African Americans (HR=1.49; 95% CI: 1.12, 1.98) and Native Hawaiians (HR=1.68; 95% CI: 1.08, 2.60), but not among non-Hispanic whites (HR=1.06; 95% CI: 0.78, 1.43), Latinos (HR=0.96; 95% CI: 0.71, 1.29), or Japanese Americans (HR=0.95; 95% CI: 0.75, 1.21). Conclusions: In this multiethnic analysis, estimates of the association between T2DM and UC were strongest among African American and Native Hawaiian participants. The apparently stronger associations in these groups may be due to greater severity and/or poorer control of T2DM. African Americans and Native Hawaiians may benefit from targeted interventions to better manage T2D in these populations to reduce risk of UC. Citation Format: David Bogumil, Victoria Cortessis, Lynne Wilkens, Veronica Wendy Setiawan, Christopher Haiman, Loic Le Marchand, Gertraud Maskarinec. History of diabetes is differentially associated with urothelial cancer risk in understudied racial/ethnic groups in the Multiethnic Cohort Study (MEC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 734.
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Chevallier, Max-Alain. "Sur un Silence du Nouveau Testament: l'Esprit de Dieu a l'Oeuvre dans le Cosmos et l'Humanite." New Testament Studies 33, no. 3 (July 1987): 344–69. http://dx.doi.org/10.1017/s0028688500014326.
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‘L'Esprit du Seigneur a rempli l'Univers et lui qui maintient tout dans l'unité, il connaît toute parole.’ Tel est l'introït de la fête de la Pentecôte dans la liturgie de l'Eglise catholique latine; c'est une citation du livre de la Sagesse (1. 7). La thèse d'une omniprésence de l'Esprit saint s'est trouvée, au cours des siècles, développée dans différentes directions. Sensible à la question de la vérité, le Moyen-Age aimait commenter une maxime datant du 4e siècle: ‘Toute vérité, quel que soit celui qui la dise, vient du Saint-Esprit.’ Préoccupé de la sécularisation contemporaine, le Concile Vatican II disait: ‘L'homme, sans cesse sollicité par l'Esprit de Dieu, ne sera jamais tout à fait indifférent au problème religieux.’ Et, soucieux comme toute notre génération de la justice dans la société, il affirmait: ‘L'Esprit de Dieu qui, par une providence admirable, conduit le cours des temps et rénove la face de la terre, est présent à [l'] évolution [des mentalités dans le sens du progrès social].’
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Ramirez, Amelie G., Rebecca T. Jones, Matthew P. Banegas, Maria C. Camargo, Gerardo Colon-Otero, Cliff Despres, Laura Fejerman, et al. "Abstract B032: Advancing the science of cancer in Latinos conference." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B032. http://dx.doi.org/10.1158/1538-7755.disp24-b032.
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Abstract Cancer is the leading cause of mortality within the Latino population. Projections suggest a 142% increase in cancer incidence among Latinos over the next two decades. This trend is concerning given that Latinos, the largest minority group in the United States, are expected to constitute at least 28% of the nation's populace by 2060. To address the need for enhanced comprehension of these trends and to identify equitable interventions targeting Latino health disparities, the Institute of Health Promotion Research and the Mays Cancer Center jointly established the biennial Advancing the Science of Cancer in Latinos (ASCL) Conference. The fourth ASCL Conference convened in San Antonio, TX from February 21-23, 2024. The conference objectives were twofold: 1) Examine the intersection of health equity and biological underpinnings in cancer control, prevention, and treatment; and 2) Foster collaborative initiatives among attendees aimed at addressing cancer-related health disparities within the Latino community. The 2024 conference attracted 286 participants compared to 251 attendees in 2022, encompassing guest speakers, researchers, physicians, healthcare professionals, patient advocates, researchers, and students. It comprised 23 sessions (3 keynotes, 6 plenaries, 6 breakouts, 3 general sessions, 1 special session, 1 lunch panel session) featuring insights from 51 speakers, alongside a poster session highlighting 80 research abstracts and a rapid-fire session tailored for early-career investigators. Sessions encompassed multiple topics relevant to Latino cancer research, spanning health disparities, clinical trials, survivorship, patient advocacy, climate change impacts on cancer, precision medicine, health policy and social determinants of health. A post-conference survey from a cohort of 48 respondents underscored high levels of satisfaction, with 90% expressing pronounced contentment regarding the conference experience, compared to 85% in 2022. Moreover, nearly all respondents (98%) rated the relevance of conference content to Latino cancer science as excellent, with 93% regarding the conference as an exceptional platform for information exchange, compared to 79% in 2022. Impressions regarding session quality were overwhelmingly positive, with 90% of respondents indicating a high level of satisfaction, and all survey respondents acknowledging the objectivity, balance, and absence of commercial bias in the session content. Our results showed that the resounding positivity in attendee feedback reflects the conference's success in fostering meaningful engagement among researchers committed to alleviating Latino cancer health disparities. The ASCL conference facilitated an understanding of cultural nuances and barriers specific to the Latino community, stimulating collaborative efforts aimed at enhancing Latino health outcomes. Overall, this retrospective analysis affirms the conference's success in achieving its stipulated objectives and underscores the need of having consistently coordinated research endeavors to reduce Latino health disparities. Citation Format: Amelie G. Ramirez, Rebecca T. Jones, Matthew P. Banegas, Maria C Camargo, Gerardo Colon-Otero, Cliff Despres, Laura Fejerman, Filipa Lynce, Martin Mendoza, Patricia I. Moreno, Alejandro Recio-Boiles, Barbara Segarra-Vazquez, Sandi Stanford, Mariana Stern, Katherine Y. Tossas, Edward J. Trapido, Nicolette M Orozco. Advancing the science of cancer in Latinos conference [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B032.
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Ramos, Alejandra, Carolina Aristizabal, and Lourdes Baezconde-Garbanati. "Abstract 1918: Reducing human papillomavirus associated cancers and disparities among Hispanics/Latinos through the adapted NCI NON CHE (National Outreach Network Community Health Education) program." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1918. http://dx.doi.org/10.1158/1538-7445.am2023-1918.
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Abstract While HPV vaccination has dramatically reduced HPV-related cancer incidences in certain demographic groups, it continues to disproportionately affect Hispanics/Latinos. The NON CHE program at (USC), (NCCC), aims to understand the gaps in Human Papillomavirus (HPV) knowledge and vaccination uptake, cervical cancer screenings, and addresses the barriers to participating in clinical trials (CT) by conducting culturally-sensitive educational workshops to the community. Methods: Materials such as a PowerPoint presentation and Human Papillomavirus Vaccination (HPV) infographics were adapted by the NCI to ensure the message can influence the target audience. Educational workshops were conducted via Zoom. Recruitment of participants were facilitated by partnering with community organizations across Los Angeles County (LAC) which is NCCC’s catchment area. The effectiveness of the workshops was assessed by delivery of pre and post surveys that captured demographics and a series of true and false questions that measured HPV knowledge. 3- and 6-month follow-up surveys are distributed among participants of those of age 18 - 26 and to parents of children 9 - 18 years of age to assess vaccination intake. Results: A total of 1,515 people have been reached during educational workshops, health fairs, and outreach events from October 2021 to September 2022. Our results demonstrate that the 236 participants, (55.6%) Spanish-speaking and (26.9%) English-speaking had not heard of HPV indicating the sparse availability and accessibility of information contributing to parents’ unfamiliarity of the HPV vaccine (79.5%) between the two groups. However, there was a positive distribution of likely to get vaccine (72.88%) and likely to vaccinate their children (47.88%.) Their lack of awareness stemmed from lack of provider motivation (44.2%) and limited health education (39.5%.) Conclusion: Conducting culturally tailored educational workshops to disseminate information on Human Papillomavirus (HPV) has helped Hispanics/Latinos understand what HPV is and reduce the stigma. Effective dissemination of HPV education requires it to be inclusive, concise, and engaging to motivate community members to seek preventive care. Citation Format: Alejandra Ramos, Carolina Aristizabal, Lourdes Baezconde-Garbanati. Reducing human papillomavirus associated cancers and disparities among Hispanics/Latinos through the adapted NCI NON CHE (National Outreach Network Community Health Education) program [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1918.
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Ridley-Merriweather, Katherine E., Stephanie M. Younker, Madeline D. Evans, and Cynthia Y. Wu. "Abstract 5930: Identifying effective communication for recruitment of minority women to a breast cancer prevention study: A novel focus group approach." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5930. http://dx.doi.org/10.1158/1538-7445.am2022-5930.
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Abstract Ensuring that minoritized women are involved in breast cancer research is important to address well-documented current disparities in cancer incidence, stages of diagnosis, and mortality rates. This study used a novel interactive focus group method to identify innovative communication strategies for recruiting women from two minority groups—Latinas and Asian Americans—into the Komen Tissue Bank, a specific breast cancer biobank clinical trial. Through activities that employed visual interactive tools to facilitate group discussion and self-reflection, the authors examined perspectives and motivations for Asian American women (N=17) and Latinas (N=14) toward donating their healthy breast tissue. Findings included three themes that, while common to both groups, were unique in how they were expressed: lack of knowledge concerning breast cancer risks and participation in clinical research, cultural influences in breast cancer risk thinking, and how altruism relates to perceived personal connection to breast cancer. More significantly, this study illuminated the importance of using innovative methods to encourage deeper, more enlightened participation among underrepresented populations that may not arise in a traditional focus group format. The findings from this study will inform future health communication efforts to recruit women from these groups into clinical research projects like the Komen Tissue Bank. These findings also illustrate the importance of applying rigorous qualitative work to supplement quantitative research to increase the inclusion of minoritized populations in clinical trials. Citation Format: Katherine E. Ridley-Merriweather, Stephanie M. Younker, Madeline D. Evans, Cynthia Y. Wu. Identifying effective communication for recruitment of minority women to a breast cancer prevention study: A novel focus group approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5930.
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Postel, Mackenzie D., Jamie K. Teer, Steven A. Eschrich, Julie Dutil, Erin M. Siegel, William D. Cress, John D. Carpten, and David W. Craig. "Abstract 3117: Molecular and clinical correlates of genetic ancestry in a diverse, admixed cancer dataset." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3117. http://dx.doi.org/10.1158/1538-7445.am2023-3117.
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Abstract The objective of this study is to determine whether genetic ancestry analysis can provide additional insight into the genetic determinants of cancer disparities distinct from socially constructed variables like self-reported race and ethnicity. The Oncology Research Information Exchange Network (ORIEN) “Avatar” project is a diverse dataset of extensive, longitudinal clinical and molecular data from 18 cancer centers across the U.S.; the ORIEN Intermember Ancestry Project cohort described in this study is a subset of the larger dataset. Using paired tumor/germline whole exome sequencing data from ORIEN, the Genome Aggregation Database (gnomAD) dataset of ancestry reference individuals, and the software tools ADMIXTURE and RFMix, we have estimated genetic ancestry for cancer cases from both ORIEN and The Cancer Genome Atlas (TCGA). The ORIEN dataset has 2.6X greater representation of self-reported Hispanic/Latinos than does TCGA, with Hispanic/Latinos making up 9% of the ORIEN dataset vs. 4% in TCGA. As expected, individuals of Hispanic/Latino ethnicity are heterogeneous in their admixture proportions of Indigenous American, African, and European ancestries. We performed statistical analyses in R to identify molecular and clinical correlations with ancestry. This study highlights the clinical utility of genetic ancestry analysis as an approach to understand the genetic contributions to cancer disparities in diverse, admixed populations. Citation Format: Mackenzie D. Postel, Jamie K. Teer, Steven A. Eschrich, Julie Dutil, Erin M. Siegel, William D. Cress, John D. Carpten, David W. Craig. Molecular and clinical correlates of genetic ancestry in a diverse, admixed cancer dataset [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3117.
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Estrada-Florez, Ana Patricia, Paul Lott, Ted Toal, Nicole Halmai, Elizabeth Quino, Alma Poceros-Coba, Alix Guevara, et al. "Abstract 2274: Identification of predisposition and progression gastric cancer biomarkers in Latinos." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2274. http://dx.doi.org/10.1158/1538-7445.am2022-2274.
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Abstract Gastric cancer (GC) disproportionally affects people of Latino ancestry and represent a leading cause of incidence and mortality disparities in this minority populations. When compared to Non-Latino Whites, Latinos are ~2-fold more likely to be diagnosed with and to die of GC. The goal of our research program is to contribute to GC research in patients of Latino ancestry and advance cancer health disparity research. One of the research projects aims at identifying germline variants associated with GC risk. To do so, we are identifying novel gastric cancer genes and detecting mutations in previously reported GC genes, using whole-exome sequencing, in 500 patients who have been diagnosed with early-onset GC and/or who had GC and family history of cancer. Whole exome sequence data collection was recently completed and is being analyzed with the primary goals of estimating the prevalence and penetrance in known cancer genes as well as the identification of new GC genes. Using in-house exome data and publicly available genetic data, we will identify variants with predicted impact in the phenotype to design a panel that will be used for their detection in gastric preneoplasia biopsies. These variants will be tested using duplex sequencing, a highly sensitive method that can detect very rare mutations with ultra-depth sequencing. We will then select the variants with likely functional consequences for tumor initiation and/or progression to generate isogenic gastric organoids to investigate their effect in proliferation, differentiation, and gene expression. We aim to generate a body of work that can be used for risk assessment, prevention, early diagnostic, and that will lead to better outcomes for GC in this important U.S. minority. Dr. Ana Estrada-Florez is the recipient of the AACR Cancer Health Disparities Fellowship. Citation Format: Ana Patricia Estrada-Florez, Paul Lott, Ted Toal, Nicole Halmai, Elizabeth Quino, Alma Poceros-Coba, Alix Guevara, Fabian Castro, Jhon Suarez, John Mcpherson, Rasika Venkatesh, Hongyong Zhang, Apri Vang, Guadalupe Polanco, Joana Guerra, Graciela Molina, Carol Parra, Adriana Della Valle, Esteban Castelao, Manuel Teixeira, Mabel Bohorquez, Javier Torres, Alejandro Carvajal Corvalan, Luis G. Carvajal-Carmona. Identification of predisposition and progression gastric cancer biomarkers in Latinos [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2274.
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MADER, BRYN J. "Selection of a lectotype for Brachycrus laticeps mooki Schultz and Falkenbach (Mammalia, Artiodactyla, Merycoidodontidae)." Zootaxa 4323, no. 3 (September 22, 2017): 415. http://dx.doi.org/10.11646/zootaxa.4323.3.6.
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In 1968 Schultz and Falkenbach described a new oreodont subspecies, Brachycrus laticeps mooki, from a locality 11 km (7 miles) southeast of Fort Logan, Meagher County, Montana. As a holotype for this new taxon, Schultz and Falkenbach (1968:369) designated both American Museum of Natural History (AMNH) specimen number 21321 (a skull) and AMNH 21322 (a left ramus). Although the citation of two separate catalog numbers as a holotype is highly unusual, Schultz and Falkenbach believed that the specimens cataloged under both numbers represent only a single individual. The use of the term ‘holotype’ was appropriate, therefore, although it would have been more common practice to place elements believed to represent a single individual under a single catalog number. Schultz and Falkenbach did not give a justification for their opinion that AMNH 21321 and AMNH 21322 represent the same individual, although they stated this belief in two publications (1941 and 1968).
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Sleiman, Marcelo, Dheeraj Oruganty, Adina Fleischmann, Mingqian Liu, Sahana Arumani, and Kenneth Tercyak. "Abstract B066: Empowering Black and Latine breast/ovarian cancer survivors with lower quality of life through community-based patient navigation programs." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B065. http://dx.doi.org/10.1158/1538-7755.disp24-b065.
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Abstract Community-based organizations (CBOs) offer essential health information and support through programming directed toward women at-risk for and surviving with breast/ovarian cancer. This includes services delivered to women of color–who are more likely to have unmet medical and psychosocial needs, and high social determinants of health burdens. Yet, little is known about the effectiveness of CBO’s programs and services on these women’s levels of empowerment (e.g., their perceived control, self-efficacy, knowledge/skills, and coping with cancer risk, treatment, and survivorship) that could impact the outcomes of their cancer care. To study this, we conducted a secondary data analysis among N=124 breast/ovarian cancer survivors identifying as Black and/or Latine participating in CBO-led cancer control activities, and assessed their care satisfaction, quality of life, patient navigation, and empowerment. Patient empowerment was high: most women of color (M age=50, 54% Black, 48% Latine) felt more informed (75%) and confident (75%) in managing their care following program engagement. Care quality was also very high (87%), and perceived as: recommendable to others (94%), helpful (91%), informative (92%), timely (90%), reliable (91%), supportive (91%), and effective (91%). Regarding care satisfaction, these underrepresented women felt supported by abundant resources (93%) and programs (95%), understood (93%), and helped (91%) by the CBOs programs. Regarding quality of life, 69% were in fair/poor health and 24% endorsed frequent mental distress–with an average of 9.1 physically unhealthy days, 9.4 mentally unhealthy days, and 7.8 activity-limited days in the past month. Disparities in empowerment were observed as a function of survivors’ navigation experiences and physical/mental well-being, as empowerment was highest among those who benefited more from patient navigation (r=.58, p<.001), and had poorer quality of life (r=-.44, p<.001). In a multivariable model controlling for satisfaction with CBO-led cancer control, both patient navigation (B=.81, SE=.13, p<.001) and quality of life (B=-.18, SE=.07, p<.005) were associated with survivors’ experience of empowerment: those who rated their patient navigation experience more highly, and those who were more impaired, felt most empowered. Community cancer control empowers Black and Latine breast/ovarian cancer survivors: addressing disparities, through programs such as patient navigation, could enhance their effectiveness, and particularly for those with lower quality of life. Behavioral and Social Science: Socioeconomic Influences Citation Format: Marcelo Sleiman Jr, Dheeraj Oruganty, Adina Fleischmann, Mingqian Liu, Sahana Arumani, Kenneth Tercyak. Empowering Black and Latine breast/ovarian cancer survivors with lower quality of life through community-based patient navigation programs [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B066.
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Sleiman, Marcelo, Dheeraj Oruganty, Adina Fleischmann, Mingqian Liu, Sahana Arumani, and Kenneth Tercyak. "Abstract B066: Empowering Black and Latine breast/ovarian cancer survivors with lower quality of life through community-based patient navigation programs." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B066. http://dx.doi.org/10.1158/1538-7755.disp24-b066.
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Abstract Community-based organizations (CBOs) offer essential health information and support through programming directed toward women at-risk for and surviving with breast/ovarian cancer. This includes services delivered to women of color–who are more likely to have unmet medical and psychosocial needs, and high social determinants of health burdens. Yet, little is known about the effectiveness of CBO’s programs and services on these women’s levels of empowerment (e.g., their perceived control, self-efficacy, knowledge/skills, and coping with cancer risk, treatment, and survivorship) that could impact the outcomes of their cancer care. To study this, we conducted a secondary data analysis among N=124 breast/ovarian cancer survivors identifying as Black and/or Latine participating in CBO-led cancer control activities, and assessed their care satisfaction, quality of life, patient navigation, and empowerment. Patient empowerment was high: most women of color (M age=50, 54% Black, 48% Latine) felt more informed (75%) and confident (75%) in managing their care following program engagement. Care quality was also very high (87%), and perceived as: recommendable to others (94%), helpful (91%), informative (92%), timely (90%), reliable (91%), supportive (91%), and effective (91%). Regarding care satisfaction, these underrepresented women felt supported by abundant resources (93%) and programs (95%), understood (93%), and helped (91%) by the CBOs programs. Regarding quality of life, 69% were in fair/poor health and 24% endorsed frequent mental distress–with an average of 9.1 physically unhealthy days, 9.4 mentally unhealthy days, and 7.8 activity-limited days in the past month. Disparities in empowerment were observed as a function of survivors’ navigation experiences and physical/mental well-being, as empowerment was highest among those who benefited more from patient navigation (r=.58, p<.001), and had poorer quality of life (r=-.44, p<.001). In a multivariable model controlling for satisfaction with CBO-led cancer control, both patient navigation (B=.81, SE=.13, p<.001) and quality of life (B=-.18, SE=.07, p<.005) were associated with survivors’ experience of empowerment: those who rated their patient navigation experience more highly, and those who were more impaired, felt most empowered. Community cancer control empowers Black and Latine breast/ovarian cancer survivors: addressing disparities, through programs such as patient navigation, could enhance their effectiveness, and particularly for those with lower quality of life. Behavioral and Social Science: Socioeconomic Influences Citation Format: Marcelo Sleiman Jr, Dheeraj Oruganty, Adina Fleischmann, Mingqian Liu, Sahana Arumani, Kenneth Tercyak. Empowering Black and Latine breast/ovarian cancer survivors with lower quality of life through community-based patient navigation programs [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B066.
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Cartujano-Barrera, Francisco, Edgar Alaniz-Cantu, Maria Valeria Bautista Rojas, Ruthmarie Hernández-Torres, Scott McIntosh, Deborah J. Ossip, and Ana Paula Cupertino. "Abstract 1971: Understanding the perspectives of Latino smokers on physical activity: A qualitative study." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1971. http://dx.doi.org/10.1158/1538-7445.am2023-1971.
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Abstract Introduction: Smoking and sedentarism frequently co-occur among Latinos. Evidence suggests that moderate to vigorous physical activity (MVPA) may enhance smoking cessation rates. However, this synergistic phenomenon has not been studied among Latinos, the largest minority group in the U.S. Objective: To understand the perspectives of Latino smokers on physical activity. Methods: Participants were recruited using community-based recruitment strategies. Semi-structured interviews were conducted in English and Spanish with Latino smokers. The Health Belief Model was used as a framework for qualitative theoretical analysis. Results: At baseline, participants’ mean age was 54.9 years old (SD 12.1), 50% of the participants were female, and 85% self-identified as heterosexual or straight. Eight participants (40%) indicated their language of preference as “Only Spanish” and 50% were born in Cuba and the Dominican Republic (25% for each country). Most participants (70%) were light smokers (1-10 cigarettes per day), 35% smoked their first cigarettes within five minutes after waking up, and 50% used menthol cigarettes. We identified perceived benefits (e.g., mood management, weight loss, strategy to quit smoking), susceptibility (e.g., risk of cardiovascular diseases and physical impairment, susceptibility to weight gain), and barriers (e.g., lack of social support, health constraints, and low financial resources) of being physically active. Moreover, we identified cues to action to do physical activity (e.g., being a role model: “⋯I’m going to do it [physical activity] so she [the daughter] can do it too⋯”; spending time with family and friends: “Well, since I have some little nephews and some little nieces... I go with them to the playground⋯”; being outdoors: “⋯go to the parks a lot or go nature walking⋯ being out in the woods⋯ taking all of nature⋯ I would go down to [local towns in New York] on my bicycle⋯”). Conclusion: Multiple perceived factors of being physically active were identified among Latino smokers. These factors provide concrete operational strategies to address smoking cessation and physical activity among Latinos. Further research is needed on how best to integrate these perspectives into smoking cessation interventions. Citation Format: Francisco Cartujano-Barrera, Edgar Alaniz-Cantu, Maria Valeria Bautista Rojas, Ruthmarie Hernández-Torres, Scott McIntosh, Deborah J. Ossip, Ana Paula Cupertino. Understanding the perspectives of Latino smokers on physical activity: A qualitative study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1971.
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Pittion, Jean-Paul. "L’Adieu du monde, ou Le Mespris de ses vaines grandeurs et plaisirs périssables du Chartreux Dom Polycarpe de la Rivière (1619) : une rhétorique de l’offuscation ?" Acta Universitatis Lodziensis. Folia Litteraria Romanica, no. 15 (December 30, 2020): 91–106. http://dx.doi.org/10.18778/1505-9065.15.07.
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L’Adieu du Monde ou Le Mespris de ses vaines grandeurs et plaisirs périssables de Dom Polycarpe de la Rivière est paru à Lyon en 1619. Son auteur qui fut chantre de la chapelle de Marguerite de Valois à Usson, et passa neuf ans à la Grande Chartreuse, met en écriture un vaste savoir joignant textes patristiques, érudition humaniste et poésies grecque, latine et française. Dom Polycarpe pratique la rhétorique de la citation, l’assortit de disquisitiones savantes et la met au service d’une dénonciation des attraits du Monde. Il convoque les autorités qu’il cite en juges et témoins. Le discours d’un mépris implacable envers les princes de l’Église, les courtisans et les femmes, n’arrive toutefois pas à masquer la parole d’un homme toujours hanté par la sensualité. Entre amour charnel et amour spirituel, l’ἔρως qui inspire le texte est plus proche de l’ésotérisme de Philon ou de Grégoire de Nysse que de l’ἁγάπη du maître de la spiritualité cartusienne, Saint Bernard. Le texte de L’Adieu du Monde est le témoin d’une forme de spiritualité partagée par certains cercles humanistes et un exemple d’écriture baroque, au crépuscule de la Renaissance française.
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Rieth, Katherine K. S., Evelyn Arana, Francisco Cartujano-Barrera, Scott McIntosh, and Ana Paula Cupertino. "Abstract B005: Decídetexto: Assessment of weight change after smoking cessation treatment in Latino smokers." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B005. http://dx.doi.org/10.1158/1538-7755.disp22-b005.
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Abstract Objective: The objective of this study is to describe weight change among Latinos participating in a randomized, culturally appropriate mobile smoking cessation intervention. Background: More than 60% of cancer-related deaths in the U.S. are attributed to tobacco use, poor nutrition, and physical inactivity. Weight gain is one of the possible barriers to smoking cessation success. The obesity rate among Latinos (44.8%) is the second-highest rate among all racial and ethnic groups. Furthermore, Latino adults have the highest rate of inactivity and 75% of Latinos do not meet the recommended levels of fruit/vegetable consumption. Therefore, the relationship between smoking cessation and weight gain among Latinos is an important aspect to consider in smoking cessation treatment for these underrepresented communities. Methods: The present study describes the weight change of participants in a culturally-tailored mobile smoking cessation program (Decídetexto) over six months. Participants were randomized to one of two conditions: 1) Decídetexto, or 2) standard care (printed materials, referral to quitline). Baseline and 6-month follow-up assessments were performed. The cessation outcome was cotinine-verified 7-day point prevalence abstinence. Weight and BMI were compared from baseline to 6-month to verify the impact of smoking cessation on weight. These changes were also compared from baseline to 6-month among intervention participants vs standard treatment participants to assess any impact of the intervention on weight. Results: Subjects (n=348) had complete weight information to be included in this analysis. Most participants were in the overweight and obese BMI categories at baseline (n=259, 74.4%). At 6 months, there was no significant change in BMI status among all participants. Weight change among those who quit at 6 months compared to those who did not quit smoking was also not statistically significant (p=.70). Quitters had an overall higher amount of absolute weight gain by one pound compared to non-quitters at 6 months (5.04±5.02 lbs vs 4.31±4.09 lbs, respectively) which was not statistically significant (p=0.33). In both the intervention and control groups, more subjects did gain weight overall (n=60,36.2% vs n=69,37.9%, respectively). More subjects lost weight in the control group compared to the intervention group (n=55,30.22% vs n=48,28.9%, respectively). Approximately one-third of both the intervention and control groups did not change their weight (n=58,34.9%, vs n=58,37.9%). There was no statistically significant difference between groups in any weight change direction (p=0.95). Conclusion: Participants in a culturally-tailored mobile smoking cessation program for Latino smokers did not experience significant changes in weight compared to standard treatment. Importantly, those who quit smoking also did not experience significant changes in weight. This is an outcome that could inform future counseling of participants in smoking cessation programs, as fear of weight gain is a significant barrier to quit success. Citation Format: Katherine K.S. Rieth, Evelyn Arana, Francisco Cartujano-Barrera, Scott McIntosh, Ana Paula Cupertino. Decídetexto: Assessment of weight change after smoking cessation treatment in Latino smokers [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B005.
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Parada, Humberto, Margaret Pichardo, Linda C. Gallo, Frank J. Penedo, David J. Lee, Gregory A. Talavera, and Hector M. Gonzalez. "Abstract B116: Cognitive performance and cognitive decline following cancer among middle-aged and older adults in the study of Latinos-investigation of neurocognitive aging and HCHS/SOL." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B116. http://dx.doi.org/10.1158/1538-7755.disp22-b116.
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Abstract BACKGROUND: Cognitive impairment is a frequently reported side-effect of cancer therapies affecting attention, concentration, memory, and executive function. However, the long-term impacts of cancer and its treatments on cognitive function and cognitive decline in Hispanics/Latinos is unknown. Herein, we examined the associations between a self-reported history of cancer and cognitive test performance cross-sectionally and longitudinally among middle-aged and older Hispanic/Latino adults. METHODS: Participants included 9,639 Hispanic/Latino adults [mean age=56.4 (SE=0.14); 54.7% female] of diverse backgrounds [30.8% Mexican, 27.2% Cuban, and 18.1% Puerto Rican; 10.0% Central American; 9.0% Dominican; and 7% South American] from the population-based, prospective, multi-site Hispanic Community Health Study/Study of Latinos. At enrollment in 2008-2011 (Visit 1), participants self-reported their history of cancer (yes/no) and cancer site(s). Cognitive function was assessed at Visit 1 and again at a 7-year follow-up assessment (Visit 2) using the Brief-Spanish English Verbal Learning Test (BSEVLT-Sum, episodic learning; and BSEVLT-Recall, memory), the Word Fluency Test (WF, verbal fluency), and the Digit Symbol Substitution Test (DSS, processing speed and executive functioning) via the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA). Changes in cognitive test performance were calculated using survey linear regression models predicting cognitive performance at Visit 2 as a function of Visit 1 cognitive performance with adjustment for time between assessments. Test scores/changes in tests scores were standardized and averaged as composites of global cognition/cognitive change. We used survey linear regression models to estimate the adjusted associations between history of cancer and baseline and longitudinal cognitive test performance. We examined these associations overall and by sex and for the most prevalent sex-specific cancers [i.e., cervical (n=121), breast (n=115), uterine (n=67), and prostate (n=48) cancers]. RESULTS: Cross-sectionally, a history of cancer (n=546) versus no history of cancer (n=9,093) was associated with higher WF scores (β=0.13, SE=0.06; P=0.03) and global cognition (β=0.08, SE=0.04; P=0.06) among all participants overall. Among men, but not among women, a history of cancer was associated with longitudinal increases in SEVLT-Sum (β=0.29, SE=0.14; P=0.04; PInteraction=0.04), and SEVLT-Recall (β=0.36, SE=0.15; P=0.02; PInteraction=0.01) scores. Among women, a history of cervical cancer was associated with longitudinal decreases in SEVLT-Recall scores (β=-0.30, SE=0.13; P=0.03) and among men, a history of prostate cancer was associated with higher baseline WF scores (β=0.29, SE=0.12; P=0.02). CONCLUSION: Cancer or its treatments may influence long-term cognition among Hispanics/Latino cancer survivors. The potential impacts of cancer or cancer treatment on cognition may vary by sex or cancer type. Citation Format: Humberto Parada Jr., Margaret Pichardo, Linda C. Gallo, Frank J. Penedo, David J. Lee, Gregory A. Talavera, Hector M. Gonzalez. Cognitive performance and cognitive decline following cancer among middle-aged and older adults in the study of Latinos-investigation of neurocognitive aging and HCHS/SOL [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B116.
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Langie, Jalen, Libby Morimoto, Xiaomei Ma, Catherine Metayer, Joseph L. Wiemels, Adam J. de Smith, and Charleston W. K. Chiang. "Abstract A079: The impact of Indigenous American ancestry on the risk of acute lymphoblastic leukemia and the implications for future study designs." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): A079. http://dx.doi.org/10.1158/1538-7755.disp24-a079.
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Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with Hispanic/Latino (H/L) children having up to 1.4 times the rate of ALL compared to their non-Hispanic White counterparts. This disparity has not been fully explained by environmental factors, suggesting the role of understudied genetic variants, particularly ones found in Indigenous American (IA) ancestry inherited by Latinos. In this study, we characterized the impact of IA ancestry on the frequency and effect size of known ALL risk alleles. We found that elevated risk of ALL in Latinos may be conferred by increased frequency of risk alleles due to IA ancestry. For instance, in an analysis of Latinos from the California Cancer Linkage Project (CCRLP; 1,930 cases, 2,103 controls) and the California Childhood Leukemia Study (CCLS; N = 605 cases, 515 controls), we found that, across independent known ALL loci (N=21), more loci than expected by chance showed a significant association between IA ancestry and increasing risk (p = 0.015). Compared to randomly-sampled, frequency-matched alleles from the genome, the risk alleles at all known ALL loci also showed a significant association with IA ancestry (46.9 % for known risk alleles vs. 43.5 % for matched alleles; ). The IA haplotype had 1.39 times the odds (95% CI: 1.35 – 1.43; ) of harboring the risk allele compared to the non-IA haplotype. Conversely, in a combined Latino sample of 2,535 cases and 9,035 controls, we found no evidence of GxAncestry interaction on ALL risk across all known loci (min P = 0.0026, prior to adjusting for multiple testing), suggesting that ALL risk alleles do not have increased effects on the IA ancestry background. This lack of synergism between local ancestry and genotype in ALL has methodological implications for gene discovery in admixed populations. To explore this, we implemented Tractor, a method that models genotype effects by ancestry, and thus is best powered in the presence of effect size heterogeneity by ancestry. Across known loci, we found that Tractor had 36.1% decreased power compared to standard GWAS. Taken together, our results suggest that the disproportionate burden of ALL in Latino populations may arise from the enrichment of risk alleles within the IA ancestry component, possibly driven by immunity- related selective pressures. Finally, future genetic studies of ALL in Latino patients may benefit from methods that incorporate contributions from ancestry to increase the statistical power in identifying associations, rather than leverage effect size heterogeneity across ancestries. Citation Format: Jalen Langie, Libby Morimoto, Xiaomei Ma, Catherine Metayer, Joseph L. Wiemels, Adam J. de Smith, Charleston W.K. Chiang. The impact of Indigenous American ancestry on the risk of acute lymphoblastic leukemia and the implications for future study designs [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A079.
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Shahab, Guleer, and Michael Preston. "Abstract 820: Decolonizing data: Diversifying cancer registries to include SWANA." Cancer Research 84, no. 6_Supplement (March 22, 2024): 820. http://dx.doi.org/10.1158/1538-7445.am2024-820.
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Abstract Southwest Asian/North African communities (SWANA) make up over 3-4% of immigrants in the U.S. and yet their health status is largely unknown because these ethnic groups are misclassified within the U.S. racial schema as White, deeming them ‘invisible minorities’. Administrative forms specify that White includes Middle-Eastern but SWANA persons may also self-identify as Black, Asian, and Other. With the rise of Islamophobia and increased US intervention in the Middle Eastern region, SWANA Americans face unique challenges that require a deeper understanding of their health status.One methodology to obtain cancer statistics on SWANA is using naming algorithms. Similar to SWANA, the Latine population was invisible in administrative data prior to the 1970’s. Grassroots efforts and advocacy from the Latine community led to the development of validated Latine surname algorithms which have been implemented by the National Cancer Institute. Similarly, SWANA activists have advocated for the creation of a federal identification category for over 50 years arguing that SWANA communities are not perceived as White due, in large part, to a long-standing history of political racism in the United States.The purpose of this study was to develop a SWANA Surname Algorithm (SSA) to inclusively identify SWANA in cancer health data. We used surnames by country of descent to leverage interpretable decision trees to effectively distinguish SWANA from non-SWANA individuals by iteratively selecting the best surname roots at which to split the data to maximize the separation of SWANA individuals from others based on their surname. We integrated these patterns into our SSA so that when presented with a new surname, the algorithm simply follows the decision patterns down to the leaf nodes, otherwise known as the predicted class (SWANA vs non-SWANA).We developed a preliminary SWANA Surname List (SSL) using publicly available naming databases by country of origin (N=71,300). We cross-referenced the SSL against the VCU Massey Cancer Center data repository and found 4.9% of all cancer patients from 2016 to 2020 matched as SWANA. Notably, the prevalence of SWANA patients has been increasing over the last few decades, 3.8% in 1991-1995, to 4.2% in 2001-2005, and then most recently 4.9% in 2016-2020. We will use our SSA to validate these findings. These preliminary findings underscore the valuable insights that naming algorithms can provide in elucidating the true demographic composition of cancer patients. Lack of racial/ethnic disaggregation perpetuates existing inequities in access to essential health resources among SWANA communities. The inclusion of SWANA in cancer disparities research would allow researchers to better examine the cancer health status of this underrepresented but growing community while also aligning with the true racialization of SWANA in the United States. Citation Format: Guleer Shahab, Michael Preston. Decolonizing data: Diversifying cancer registries to include SWANA [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 820.
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Pichardo, Catherine M., Jesse J. Plascak, Lisa A. Sanchez-Johnsen, Amber Pirzada, Amanda L. Roy, Margaret S. Pichardo, Earle C. Chambers, et al. "Abstract 32: Patterns of segregation among diverse Hispanic/Latino adults- implications for cancer prevention." Cancer Research 82, no. 12_Supplement (June 15, 2022): 32. http://dx.doi.org/10.1158/1538-7445.am2022-32.
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Abstract Background: Residential segregation has been associated with cancer incidence and mortality. Hispanic/Latinos (HL) experience moderate to high residential segregation. Purpose: This study investigates levels of racial and ethnic residential segregation and racialized economic concentrations at the extremes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods: We used baseline data from 16,415 HL adults enrolled in the Hispanic Community Health Study/Study of Latinos between 2008-2011 from the Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA. Segregation measures were calculated from census tract-level (2006-2010 American Community Survey and 2010 decennial census). We measured residential segregation using the % HL Gini coefficient, to capture variability of HL residents within the census tract, and the isolation index, to capture the probability that HL residents come into contact with other members of the same minority group. We measured racialized economic (race/ethnicity + income) concentration using the Index of Concentration at the Extremes (ICE), to capture spatial social polarization at the extremes. We compared means of HCHS/SOL population characteristics using linear regression and adjusted Wald tests for continuous, binary, and categorical variables, respectively, calculated from weighted complex samples analyses. Results: On average, overall segregation was moderate to high (M±SE): Gini (0.39 ± 0.00); Isolation (0.76 ± 0.01); ICE (race: -0.64 ± 0.01; income: -0.29 ± 0.01; race + income: -0.26 ± 0.01). HL adults who were older (> 65 y: 0.80 ± 0.01; 45-65 y: 0.77 ± 0.008; 18-44 y: 0.75 ± 0.75, p = .000) and foreign/territory-born residing in US <10 years (0.81 ± 0.009; p = 0.000; foreign/territory-born residing in US >=10 years: 0.76 ± 0.01; vs. US born: 0.70 ± 0.01) and preferred Spanish (0.79 ± 0.01; p = .000 vs. English: 0.69 ± 0.007) experienced higher racial/ethnic segregation as measured by the Isolation index. HL of Cuban (0.42 ± 0.006, p = 0.049) vs. all other heritage experienced the as measured by the % HL Gini index. We found higher levels of racialized economic segregation among foreign/territory-born residing in US <10 years (-0.32 ± 0.01) vs. foreign/territory-born residing in US >= 10 years (-0.26 ± .01) and US born (-0.21 ± 0.01; p = 0.000); individuals that preferred Spanish (-0.28 ± 0.01) vs. English (-0.21 ± .01; p = 0.000); and self-reported Cuban heritage (-0.42 ± 0.01; p = .000) vs all other heritage. Conclusion: Using multiple, measures of segregation, we found that HL adults who were older, foreign born, and preferred Spanish experienced moderate and high levels of segregation. It is important for future work to examine the impact of racial/ethnic and economic segregation on social determinants of cancer disparities within segregated environments among diverse HL. Citation Format: Catherine M. Pichardo, Jesse J. Plascak, Lisa A. Sanchez-Johnsen, Amber Pirzada, Amanda L. Roy, Margaret S. Pichardo, Earle C. Chambers, Sheila F. Castañeda, Ramon A. Durazo-Arvizu, Krista M. Perreira, Tanya P. Garcia, Matthew Allison, Jordan Carlson, Martha L. Daviglus, Gregory A. Talavera, Linda C. Gallo. Patterns of segregation among diverse Hispanic/Latino adults- implications for cancer prevention [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 32.
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Acuna, Nicholas, Kali Zhou, Paulo Pinheiro, Tiffany Lim, Lynne Wilkens, Loic Le Marchand, and Veronica Wendy Setiawan. "Abstract C110: The role of generation on hepatocellular carcinoma risk among US Mexicans in Los Angeles." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): C110. http://dx.doi.org/10.1158/1538-7755.disp22-c110.
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Abstract Background. Incidence of hepatocellular carcinoma (HCC) is nearly twice as likely to occur among Hispanics/Latinos compared to their Non-Hispanic White counterparts. Studies show that birthplace may play a role specifically where US-born Hispanic/Latinos are at a greater risk of developing HCC compared to foreign-born Hispanic/Latinos, which may be due to acculturation. Given this information, we looked at how generations in the US impact HCC risk among US Mexicans. Methods. The Multiethnic Cohort (MEC), a prospective study with over 215,000 participants in Los Angeles, CA and Hawaii. The MEC regularly performs linkages with the Surveillance, Epidemiology, End Results (SEER) Program. International Classification of Diseases for Oncology, Third Edition (ICD-O-3) codes C.22 and histology codes 8170-8175 to identify HCC cases up until December 31st, 2017. We subset our sample to self-identified Mexicans with information on parental birthplace (n=32,239). Generation status was categorized by 1st generation as born in the Mexico with both parents born in Mexico; 2nd generation as US-born with at least one parent born in Mexico; and 3rd generation as US-born with both parents also born in the US. To assess HCC risk, we performed multivariable Cox models adjusting for age, sex, body mass index (BMI), smoking status, alcohol intake, history of diabetes, and daily coffee consumption. Results. After an average follow-up time of 23.4 years there were a total of 220 HCC incident cases. With successive generation, US-Mexicans were more likely to be current smokers, have a greater intake of alcohol, consume more coffee, and have an elevated BMI. In addition, there was an increase in age-adjusted HCC incidence rates (per 100,000) with each increasing generation (1st generation: 20.9, 2nd generation: 27.5, 3rd generation: 34.7). In the multivariable model, 2nd and 3rd generation US Mexicans had a 35% (95% CI: 1.00-1.84) and 61% (95% CI: 1.10-2.36) increased risk of HCC compared to 1st generation US Mexicans, respectively (Ptrend=0.009). While we did not observe significant heterogeneity by diabetes status (Pheterogeneity=0.41); those who did not have diabetes and were 3rd generation had an 82% (95% CI: 1.17-2.84) increased risk of HCC compared to a 1st generation US Mexicans who also did not have diabetes. There was also no heterogeneity by BMI status (Pheterogeneity=0.92) and alcohol intake (Pheterogeneity=0.46) for the association between generation status and HCC risk. Among HCC cases, similar distributions of tumor grade or stage at diagnosis were observed across generations. Conclusions. 2nd and 3rd generation US Mexicans have a significantly higher risk of HCC compared to 1st generation US Mexicans. Targeted interventions focusing on healthier lifestyle behaviors are much needed for US-born Mexicans reduce HCC risk. Citation Format: Nicholas Acuna, Kali Zhou, Paulo Pinheiro, Tiffany Lim, Lynne Wilkens, Loic Le Marchand, Veronica Wendy Setiawan. The role of generation on hepatocellular carcinoma risk among US Mexicans in Los Angeles [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C110.
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Segarra-Vazquez, Barbara, Sandi Stanford, and Susanne Schmidt. "Abstract B169: Diversifying cancer patient advocate voices to eliminate health disparities." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B169. http://dx.doi.org/10.1158/1538-7755.disp24-b169.
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Abstract Cancer patient advocates have become key members in clinical research teams and participating in decision committees at FDA, NCI, ASCO, among others. There is a low number of Latino patient advocates actively participating in the above roles lacking opportunities to share lived experiences and challenges of their communities. Being able to sit at the table where advocates can share key issues and possible solutions can help eliminate health disparities. Based on the need to increase Latinos participation as research advocates, a training program was developed. The Latino cancer patient advocate training program was design to increase knowledge and develop a community of diverse individuals who can seek opportunities to participate in research teams and decision-making committees. The training program included 15 individuals and 4 mentors who were cancer patients, survivors and caregivers and were Latinos or from Latino descent. The training included four virtual sessions, one in-person session, and attending the conference advancing the science of cancer in Latinos. Those chosen to participate received a full scholarship. The dissemination process through emails and social media included a flyer with the requirements, inclusion criteria, and a link to the application form. A total of 34 people applied, 20 were interviewed, and 15 were selected. The participants were from eleven different states and represented different types of cancer. A based questionnaire before the training, one after the training was completed by the participants. A questionnaire comparing their knowledge before and after two virtual sessions and the in-person training was completed by 93.3% participants. Self-rated knowledge scores ranged from 1 (not knowledgeable at all) to 5 (extremely knowledgeable). The average knowledge score across all questions was 2.9 (somewhat knowledgeable) before the training and 4.0 (moderately knowledgeable) after participating in the training. Participants indicated having the most knowledge about “Resources for your cancer type” (average score: 3.6 before and 4.2 after) and “Patient Advocates” (average score: 3.4 before and 4.1 after) and the least knowledge about “Opportunities and Scholarships available for Advocates” (average score: 2.1 before and 3.8 after), which had the largest increase in knowledge. In terms of satisfaction with the overall training program, all participants were very satisfied (85.7%) or satisfied (14.3%). Further, 71.4% of participants strongly agreed and 28.6% of participants agreed that they were interested in becoming a scientific/research advocate because of their participation in the training. Other outcomes after the training include participants being invited to be DoD reviewers, panelists in conferences, participation in important committees. Furthermore, participants communicate weekly with each other sharing opportunities and information. This training provided knowledge and the opportunity to feel represented as Latino patient advocate diversifying the voices of advocates. Citation Format: Barbara Segarra-Vazquez, Sandi Stanford, Susanne Schmidt. Diversifying cancer patient advocate voices to eliminate health disparities [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B169.
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Jones, Veronica, Noe Chavez, Vanessa M. Robles, Laura Kruper, Lily Lai, Amy Polverini, Lusine Tumyan, et al. "Abstract B076: A qualitative exploration of women’s understanding of clinical research and decisions to participate: Improving diversity in clinical research." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B076. http://dx.doi.org/10.1158/1538-7755.disp22-b076.
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Abstract BACKGROUND: Twenty-nine years since the National Institutes of Health (NIH) Revitalization Act was passed to encourage minority participation in clinical trials (CTs), and yet there remains a deficit of minorities recruited into CT. This induces the idea that Women-of-Color (WoC) (Blacks, Latinas, Native Americans, Asians) are less likely to participate than their Northern/European White (NE/W) counterparts. Using a mixed methods study that included quantitative surveys and qualitative interviews, we dive into understanding how a diverse group of women understand and perceive CT, along with concerns and attitudes towards clinical research. METHOD: The interview script was designed to capture patients’ understanding and concerns of clinical research, reasons for agreeing or declining participation, and facilitators or barriers to participation. The CRAs were trained in establishing rapport with the patient, clearly communicating the questions, and probing for more elaboration of responses. Interviewees and interviewers were matched based on gender and race. A total of four CRAs conducted the interviews – two Asian CRAs interviewed the Asian participants, one Latina CRA interviewed Latinas and White, non-Hispanics, and one African American CRA who interviewed the African American participants. Structured individual interviews were conducted by trained CRAs. The audio-recordings of all interviews were transcribed word for word and reviewed for accuracy. Two independent coders then read and coded each transcript and extracted a set of quotes (phrases or sentences) that reflected the themes. RESULTS: A total of 44 women were accrued between August 2019 and February 2020. The racial/ethnic makeup include the following: 20 Latinas ([White/Hispanic] - one Salvadorian, one half Mexican/half Armenian, and 18 Mexican), 8 Asian (one half Chinese/half Japanese, one Indian, three Chinese, two Vietnamese, one Thai), 8 African American/non-Hispanic, and 8 White/non-Hispanic (two Iranian and 6 European). Age range of women were 27 to 71 years of age. Seventeen women declined participation. CONCLUSION: The in-person interviews highlighted feelings of cultural mistrust among the WoC participants and not in the NE/W participating in the study. The results highlight the influence of cultural mistrust as a barrier and the importance of diversity of the clinical research team in overcoming this barrier, particularly among WoC clinical trial participants. Of course, there is undeniable heterogeneity within the WoC population; each community is influenced by its own historical and present contexts that influence its relationship with the medical system. Approaches to overcome this barrier must address the specific needs of each community. Diversity of the clinical research team and the ability of the team to address culturally relevant beliefs can increase trial diversity. The generalizability, quality, and effectiveness of healthcare treatment requires diverse representation in all clinical trials. Citation Format: Veronica Jones, Noe Chavez, Vanessa M. Robles, Laura Kruper, Lily Lai, Amy Polverini, Lusine Tumyan, Lesley Taylor, James Waisman, Angelica Sanchez, Christine Thai, Tanya Chavez, Nikita Wright. A qualitative exploration of women’s understanding of clinical research and decisions to participate: Improving diversity in clinical research [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B076.
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Hydren, Jay R., Nathan W. Sweeney, David F. Barton, Jorge Arturo Hurtado Martinez, and Jennifer M. Ahlstrom. "Abstract A004: What are the top myeloma patient concerns at and since diagnosis of Mexicans, Hispanics and Latinos?" Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): A004. http://dx.doi.org/10.1158/1538-7755.disp22-a004.
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Abstract BACKGROUND: Learning about a new multiple myeloma (MM) or smoldering MM (SMM) diagnosis is an important but difficult first step of a cancer journey. However, the education process can be overwhelming, especially within ethnic minorities and the medically underserved. Moreover, recent studies suggest that too much information may lead to confusion, frustration, and could negatively impact the decision-making process. Therefore, the primary purpose of this survey was to capture the common questions and concerns of MM and SMM patients when they were newly diagnosed and since diagnosis within the Mexican, Hispanic and Latino ethnicities and compare their responses to non-Hispanic or Latino ethnicities. METHODS: We utilized HealthTree® Cure Hub and invited patients with MM or SMM to participate in an online survey consisting of selecting from a list of 20 topics of what their questions were at diagnosis and since diagnosis. RESULTS: Of the 36 myeloma patients identified as Mexican, Hispanic or Latino 86% had MM and 14% had SMM, 95% were diagnosed before 2019, 91% saw a specialist, 66±8 years, 53% female, 56% retired, 31% reported currently working, and 97% had health insurance. The non-Hispanic or Latino group consisted of 248 patients, 78% with MM and 26% with SMM, 81% were diagnosed before 2021, 78% saw a specialist, 65±8 years, 58% female, 52% retired, 29% reported currently working and 98% had health insurance. The top 5 questions at diagnosis were identical between groups: What are the myeloma treatment options?, What is my life expectancy?, What is myeloma?, What can I expect during treatment?, and Can myeloma be treated? However, since diagnosis the top 5 concerns changed and a key divergence between groups occurred. Importantly, the top new concern for both groups was, Is a clinical trial right for me?, and both groups added the question: What side effects would I experience? The two groups did differ, the non-Hispanic group added one additional question: What can I do to prevent further spread of the disease? While, in contrast, the Mexican, Hispanic and Latino group added two questions, within a similar domain, which was not previously observed: Should I consider a second opinion?, and Does my doctor have sufficient experience? DISCUSSION & CONCLUSION: These results identified major concerns of MM and SMM patients at and since diagnosis and this study documents critical ethnicity divergence that occurs as patients become more experienced with managing their myeloma. Interestingly, both ethnicities shared the same top 5 concerns at diagnosis and had some similarities of new concerns since diagnosis. However, the Mexicans, Hispanics, and Latinos reported new concerns that involved questioning their doctors’ competence and the desire of a second medical opinion for medical decisions. In conclusion, although ethnic groups largely have similar questions and concerns at and since diagnosis, Mexican, Hispanics and Latinos express interest in assuring they are being treated by experienced doctors and highly value second medical opinions. Citation Format: Jay R. Hydren, Nathan W. Sweeney, David F. Barton, Jorge Arturo Hurtado Martinez, Jennifer M. Ahlstrom. What are the top myeloma patient concerns at and since diagnosis of Mexicans, Hispanics and Latinos? [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A004.
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Parada, Humberto, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F. Olshan, Kelly R. Evenson, Thomas E. Rohan, Robert C. Kaplan, et al. "Abstract PR015: Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): PR015. http://dx.doi.org/10.1158/1538-7755.disp24-pr015.
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Abstract Background: Cancer is the leading cause of death among Hispanic/Latino adults in the United States (US). However, few studies have examined how cancer incidence varies by Hispanic/Latino heritage. Herein, we describe the incidence rates of cancer overall, for screen- detectable cancers, and for subsets of cancers that share common etiologic factors, including tobacco-related and obesity-related cancers among participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods: We included 16,415 adults ages 18-74 from the HCHS/SOL, an ongoing population-based prospective cohort study of Hispanic/Latino adults from diverse backgrounds from four field centers (Bronx, NY; Miami, FL; San Diego, CA; and Chicago, IL). The HCHS/SOL cohort participant records were linked to the state cancer registries in New York, Florida, California, and Illinois to ascertain cancer incidence from the baseline examination (2008-2011) through the end of 2021. We used Poisson regression to estimate weighted age-adjusted cancer incidence rates (IRs), and Cox regression to estimate weighted age- and sex-adjusted hazard ratios (HRs) of overall cancer and cancer groups, for all participants combined and by heritage groups. Results: Over a mean follow-up of 10.7 years (5th percentile=7.4, 95th percentile=13.1 years), 715 incident invasive cancers were diagnosed in the HCHS/SOL cohort, including the leading cancers: 118 female breast, 102 prostate, and 79 bronchus and lung cancers. The age-adjusted IR of all cancers combined was 33.7 [95% confidence interval (CI)=29.7-38.1] per 10,000 (10K) person-years (py). IRs of all cancers combined were lowest among persons of Mexican descent [IR=19.0 (95%CI=15.0-24.1) per 10K py] followed by those of Central American [IR=19.7 (95%CI=14.2-27.4) per 10K py], South American [IR=23.0 (95%CI=15.5-34.1) per 10K py], Dominican [IR=26.9 (95%CI=19.8-36.5) per 10K py], Cuban [IR=27.9 (95%CI=21.3-36.4) per 10K py], and Puerto Rican [IR=36.6 (95%CI=28.4-47.0) per 10K py] descent. Compared to those of Mexican descent, those of Puerto Rican descent had a 92% [HR=1.92 (95%CI=1.36-2.72)] higher hazard of cancer, while those of Cuban descent had a 47% [HR=1.47 (95%CI=1.07-2.03)] higher hazard and those of Dominican descent had a 40% [HR=1.40 (95%CI=0.97-2.03)] higher hazard. Compared to other Hispanic/Latino heritage groups, the incidence of obesity-related cancers was the highest among Puerto Ricans, while the incidence of tobacco-related cancers was highest among those of Puerto Rican and Cuban descent. Conclusions: Cancer incidence rates varied by Hispanic/Latino heritage and were masked when Hispanics/Latinos were aggregated into a single group. Understanding disparities in cancer risk by Hispanic/Latino heritage may help tailor cancer prevention and control strategies. Citation Format: Humberto Parada, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F. Olshan, Kelly R. Evenson, Thomas E. Rohan, Robert C. Kaplan, Caroline A. Thompson, Linda C. Gallo, Frank J. Penedo, Jianwen Cai, Sylvia Wassertheil-Smoller, Bharat Thyagarajan, Stefani N. Thomas, Olga L. Garcia-Bedoya, Gregory A. Talavera. Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr PR015.
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Chalela, Patricia, Vivian Cortez, Sandra Sivak, Armida Flores, Martha De La Mora, Zully Garcia, Byeongyeob Choi, et al. "Abstract B021: Quitxt research study: A mobile messaging intervention to promote smoking cessation among young adult smokers in South Texas." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): B021. http://dx.doi.org/10.1158/1538-7755.disp24-b021.
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Abstract Background: Despite major advances in tobacco control and treatment, tobacco use remains the single largest preventable cause of morbidity and mortality in the US. Smoking prevalence is highest among Texas young adults (ages 18-29), especially those with lower education and income and those living in rural areas, like Latinos. About 19.2% of Latinos ages 18-29 in the study areas are current smokers, putting them at higher risk of cancer and other tobacco-related morbidity and mortality. Young adults are heavy users of smartphones, text messaging, social media chats, and other mobile social media, providing a remarkable opportunity for innovation in the delivery of health promotion interventions to reduce health disparities in this large and rapidly growing racial/ethnic population. This research study aims to assess the effectiveness of Quitxt, our culturally appropriate mobile smoking cessation program. Quitxt – launched by our interdisciplinary research team using proven social cognitive, motivational interviewing, and brief intervention methods for promoting behavior change – blends bilingual text and social media messaging for smoking cessation tailored to the language and culture of young adult smokers in our vulnerable region of South Texas. The team also adapted the program to the Primary Care and Mays Cancer Center patient population, and it is currently being implemented. Quitxt has not been tested in a research study, as its creation as an evidence-based cancer prevention service for young adult smokers was supported by the Cancer Prevention and Research Institute of Texas. Methods: The proposed 5-year study involves a 2-group parallel randomized controlled trial with 4 assessments (baseline, 1, 3, and 6 months) and will recruit 1,200 young adult Latino smokers: 1)The intervention group will receive Quitxt (text messaging or chat); and 2) the usual care group will receive abbreviated text messaging with health promotion-related content, including smoking cessation and referral to the Texas DSHS cessation program YesQuit. Smoking cessation will be validated via biological tests for those who report smoking cessation at the study follow-ups. We hypothesize that the group receiving the Quitxt intervention will achieve significantly higher smoking cessation rates than the group receiving usual care. Results: The proposed intervention will mark the first significant study to assess the effectiveness of an innovative, bilingual, culturally, and linguistically appropriate mobile cessation intervention tailored to young adult Latinos living in South Texas by enhancing their skills development, competence, and self-efficacy to initiate and maintain cessation. Conclusion: This study will advance public health by testing the effectiveness of a scalable, evidence-based, easily disseminated, and adaptable intervention with potentially broad national reach to help young adults stop smoking and reduce smoking-related cancer and chronic disease morbidity and mortality and their associated healthcare costs. Citation Format: Patricia Chalela, Vivian Cortez, Sandra Sivak, Armida Flores, Martha De La Mora, Zully Garcia, Byeongyeob Choi, Edgar Muñoz, Cliff Despres, Alfred L. McAlister, Qurathul Ahmed, Audrey Cordova, Maria I. Sung-Cuadrado, Luis F. Velez, Sahak Kaghyan, Rahul Mundlamuri, David Akopian, Amelie G. Ramirez. Quitxt research study: A mobile messaging intervention to promote smoking cessation among young adult smokers in South Texas [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B021.
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Rolon, Angelica M., April P. Vang, J. Elizabeth Quino, Ana Estrada, Eric Stewart, Rosemary D. Cress, Luis Carvajal-Carmona, and Alexa Morales Arana. "Abstract 2243: A multi-ethnic population-based pilot study of multiple myeloma disparities." Cancer Research 84, no. 6_Supplement (March 22, 2024): 2243. http://dx.doi.org/10.1158/1538-7445.am2024-2243.
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Abstract To understand multiple myeloma (MM) disparities we established the Precision MEDicine, EqUity and Disparities Research in MultipLe MyeLomA (MEDULLA) study, a population-based study in California. Our study contacted, via the Cancer Registry of Greater California (CRGC), 100 adult MM patients from four racial/ethnic groups: Non-Hispanic Black (NHB), Non-Hispanic White (NHW), Latinos, and Asians. Data collection included variables reported to the CRGC, a self-administered survey, and biospecimen saliva collection. The survey focused on demographics, risk factors, cancer treatment, family history, quality of life, and social determinants of health. Of the 400 MM patients, we had 95 patients who responded to the survey, giving a response rate of 24%. 44% of those who responded were NHW, 21% NHB, 19% Latinos, and 16% Asians. Those that provided a response tend to be living in a census tract location with lower proportions of poverty (p=0.0004), higher proportion of adults ages 25 years or over with a college degree (p=0.0011), higher median household income (p=0.0048), lower proportion of adults ages 25 years or over without a high school diploma (p<0.0001), and a lower proportion of individuals ages 16 or over who are unemployed (p<0.006). All respondents also have a lower comorbidity count and expressed being in good health. For minorities, we identified a trend where a higher response rate is seen if they live in an area where median household income is higher (p=0.0108). For every 1% increase in poverty rates, NHW living in such neighborhoods were 3% less likely to respond to the survey (p=0.04). For every 10% increase in the proportion of individuals having a college degree, response rate increased by 1.17 for minorities in that neighborhood (p=0.07). Minorities living in neighborhoods with high proportions of adults without a high school diploma and high unemployment rates are less likely to respond (p=0.02 and p=0.047, respectively). In conclusion, we found significantly lower participation rates among minority groups, with socio-economic factors affecting response rates. Our findings, therefore, suggest that future studies must develop improved community-focused and culturally tailored strategies to engage and meaningfully understand MM etiology and survivorship in such populations. Citation Format: Angelica M. Rolon, April P. Vang, J. Elizabeth Quino, Ana Estrada, Eric Stewart, Rosemary D. Cress, Luis Carvajal-Carmona, Alexa Morales Arana. A multi-ethnic population-based pilot study of multiple myeloma disparities [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2243.
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Kane, Anju F., and Lourdes Baezconde-Garbanati. "Abstract A162: The influence of parental barriers to healthcare on adolescent HPV vaccination uptake and completion among Latinos in Los Angeles." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (September 21, 2024): A162. http://dx.doi.org/10.1158/1538-7755.disp24-a162.
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Abstract Objective: This study aims to investigate the association between parental barriers to healthcare access and HPV vaccination uptake among Latino adolescents in Los Angeles. Background: Human papillomavirus (HPV) induced cervical cancer (CC) remains a significant public health concern. Routine HPV vaccination has been recommended in the United States for girls since 2006 and boys since 2011 yet disparities in vaccine initiation and completion persist, particularly among Latino adolescents in Los Angeles. Methods: This cross-sectional study analyzed child data provided by mothers recruited from the Es Tiempo campaign (2016-2018). A total of 353 Latino adolescents aged 9 to 26 years were included in the sample. We used crosstabs to assess vaccine initiation and completion differences by child sex and birth order, while logistic regression models were used to evaluate the association between parental barriers to healthcare, such as lack of health insurance and access to a primary care provider (PCP), and HPV vaccination initiation. Results: Among the sample, 44% initiated the HPV vaccine, and 23% completed the series, with significantly higher rates among girls and firstborn children. Regarding barriers, lack of health insurance was associated with decreased odds of HPV vaccination uptake while access to a PCP showed a slight increase in vaccination uptake odds. Conclusion: HPV vaccination uptake among Latino adolescents in Los Angeles remains suboptimal, with disparities observed by gender and birth order. To improve public health outcomes, targeted interventions are needed to increase HPV vaccination uptake among Latino adolescent boys, and further research is needed to understand vaccine adherence patterns within families and among siblings. Moreover, while parental barriers to healthcare may influence vaccination uptake, future studies should also explore how factors like parental education level and socioeconomic status influence HPV vaccination status in combination with access barriers. Citation Format: Anju F. Kane, Lourdes Baezconde-Garbanati. The influence of parental barriers to healthcare on adolescent HPV vaccination uptake and completion among Latinos in Los Angeles [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A162.