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Dissertations / Theses on the topic 'Citrate metabolism'

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1

Levasseur, Rémi. "Aluminum citrate transport and metabolism in Pseudomonas fluorescens." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0018/MQ46489.pdf.

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2

Júnior, Celso Heitor de Freitas. "Avaliação metabólica de homens idosos portadores de litíase urinária." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-12012012-154818/.

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OBJETIVOS: O aumento da expectativa de vida tem gerado um envelhecimento populacional global, fazendo com que a proporção de indivíduos com mais de 60 anos de idade cresça mais rapidamente do que as demais faixas etárias. A incidência de litíase urinária em indivíduos idosos tem aumentado nos últimos anos, principalmente em nações industrializadas. Aspectos particulares do envelhecimento orgânico aumentam a morbidade associada à litíase urinária em idosos, tornando a prevenção e o tratamento clínico ainda mais relevantes nessa faixa etária. Nosso objetivo é analisar a avaliação metabólica de h
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3

Jeffery, David. "Studies on citrate and malate metabolism in Lycopersicon esculentum." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353243.

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The specific activities of citrate synthase and malate dehydrogenase extracted from mature green fruit of Lycopersicon esculentum, fell 60% during the first two weeks of a twelve week experiment in which the fruit were stored in an atmosphere designed to inhibit ethylene synthesis. Throughout the remainder of the experiment, the specific activities were relatively constant. In the initial two week period, the specific activity of NADP-linked malic enzyme rose by 400%, malic acid concentration fell by 50%, while the concentration of citric acid rose by 20%. Those features of ripening such as th
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4

Al-Tarrah, Mustafa. "The effect of citrate synthase on skeletal muscle metabolism." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=235778.

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Citrate synthase (CS) is a key mitochondrial enzyme in the tricarboxylic acid cycle (TCA). TCA provides NADH and FADH for the ETC to generate ATP through oxidative phosphorylation in muscle cells. The aim of this PhD project is to investigate the role of CS in skeletal muscle metabolism. The aim of the first study was to investigate the effects of a high fat diet (HFD, 45 % kcal fat) for 12 weeks on CS activity in the heart and gastrocnemius muscle of C57BL/6J (B6) mice and congenic (B6.A) characterised by 39% reduced CS activity. Spectrophotometric analysis of CS activity in the heart and gas
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Dufort, Fay Josephine. "Contribution of Glucose Metabolism to the B Lymphocyte Responses." Thesis, Boston College, 2012. http://hdl.handle.net/2345/3161.

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Thesis advisor: Thomas C. Chiles<br>B-lymphocytes respond to environmental cues for their survival, growth, and differentiation through receptor-mediated signaling pathways. Naïve Blymphocytes must acquire and metabolize external glucose in order to support the bioenergetics associated with maintaining cell volume, ion gradients, and basal macromolecular synthesis. The up-regulation of glycolytic enzyme expression and activity via engaged B-cell receptor mediated-events was glucose-dependent. This suggests an essential role for glucose energy metabolism in the promotion of B cell growth, survi
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6

Roberts, Andrew. "Crassulacean acid metabolism and photosynthetic plasticity in the genus Clusia : an ecophysiological study." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360879.

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7

Saeed, Saima. "The role of mitochondrial citrate synthase in the metabolism of developing potato tubers." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621806.

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8

Sienkiewicz-Porzucek, Agata. "Evaluation of the role of mitochondrial citrate synthase, mitochondrial and cytosolic isoforms of isocitrate dehydrogenase in tomato leaf metabolism." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16074.

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Der Citratzyklus (TCA) ist einer der bedeutendsten Stoffwechselwege für alle lebenden Organismen. Trotz der zentralen Rolle dieses Prozesses im Pflanzenmetabolismus ist er nur relativ wenig untersucht worden. In dieser Arbeit berichte ich über die Produktion und die funktionale Analyse von Tomatenpflanzen (Solanum lycopersicum), die unabhängig eine leicht eingeschränkte Aktivität der mitochondrialen Citrat-Synthase (CS) und zweier Isocitrat-dehydrogenasen (mitochondriale NAD-IDH und cytosolische NADP-ICDH) zeigen. Die transgene Pflanzen wiesen mehrheitlich keine erkennbare Veränderung eines W
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9

Daniels, Martin André [Verfasser]. "The mammalian citrate transporter mINDY (I’m not dead yet) and its protective role in hepatic metabolism / Martin André Daniels." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228860742/34.

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10

Alhindi, Yosra. "Effects of low citrate synthase activity on physiological responses of mice to high fat diet and palmitate induced lipotoxicity." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231391.

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The main aim of this thesis was to examine the hypothesis that the A/J strain variant of H55N substitution affects citrate synthase (CS) enzyme activity and metabolic health in mice fed a high fat diet (HFD). C57BL/6J (B6) mice and congenic B6.A-(rs3676616-D10Utsw1)/KjnB6 (B6.A) mice, a strain which carries the A/J allele of Cs on the B6 strain background, were fed a HFD (45% kcal from fat) for 12 weeks. CS activity, but not that of ß-hydroxyacyl-coenzyme dehydrogenase was lower in the gastrocnemius muscle of B6.A mice compared to B6 mice (P< 0.001). During HFD feeding the glucose tolerance of
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11

Da, veiga moreira Jorgelindo. "Modélisation de la bascule métabolique chez les cellules eucaryotes : application à la production de citrate chez la levure Yarrowia lipolytica." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX015/document.

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L’objectif de ce projet de thèse est d’étudier et caractériser les mécanismes impliqués dans la bascule respiro-fermentaire chez des cellules eucaryotes dotées d’un métabolisme mitochondrial. Les cellules eucaryotes ont des besoins différents en oxygène pour la production d’énergie et leur survie dans un environnement donnée. Elles sont qualifiées de type aérobie stricte lorsque la présence d’oxygène leur est nécessaire ou aéro-anaérobie facultatif dans le cas où l’oxygène n’est pas indispensable à la production d’énergie. La levure Yarrowia lipolytica a été choisie comme modèle d’étude de par
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12

Ladeira, Courelas da Silva Ana Rita [Verfasser], and Martina [Akademischer Betreuer] Muckenthaler. "Citrate Defines a Regulatory Link Between Energy Metabolism and the Liver Hormone Hepcidin / Ana Rita Ladeira Courelas da Silva ; Betreuer: Martina Muckenthaler." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1180985338/34.

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13

Eicher, Camille. "Adaptive evolution and acid tolerance of the wine bacterium Oenococcus oeni." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. https://nuxeo.u-bourgogne.fr/nuxeo/site/esupversions/8f1a0519-c564-4cfe-ae5a-1e0bc656416c.

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Oenococcus oeni est la principale bactérie lactique responsable de la fermentation malolactique en vin. Cette deuxième étape de fermentation permet la diminution de l’acidité totale, d’apporter rondeur, souplesse et stabilité microbiologique aux vins concernés. Les conditions physico-chimiques du vin affectent le développement des microorganismes par la combinaison de plusieurs facteurs de stress qui peuvent sérieusement compromettre le bon déroulement de la fermentation malolactique. Une attention particulière a été portée sur le stress acide, l’objectif étant de mettre en évidence des mécani
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14

Hanse, Marine. "Rôle du récepteur aux lipoprotéines, LSR, dans la régulation du transport et de la distribution des lipides alimentaires." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL086N/document.

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Le récepteur hépatique aux lipoprotéines LSR est impliqué dans la clairance des lipoprotéines riches en triglycérides telles que les résidus de chylomicrons pendant la phase postprandiale. La réduction de l’expression du LSR chez la souris (LSR+/-) est associée à une dyslipidémie et une lipémie postprandiale élevée. Afin de mieux comprendre la régulation de la distribution des lipides alimentaires, nous avons cherché quels étaient les facteurs pouvant affecter le niveau protéique de LSR. La leptine, hormone sécrétée par le tissu adipeux et connue pour son action d’hormone de satiété au niveau
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15

Hall-Ponselè, Andrew M. "Genetic engineering of the primary/secondary metabolic interface in tobacco BY-2 cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:be5a3ee3-33c7-455c-b043-409987395f98.

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The supply of precursors from primary metabolism is often overlooked when engineering secondary metabolism for increased product yields. This is because precursor supply may be assumed to be non-limiting, and it is considered difficult to engineer primary metabolism, because control of carbon flow (flux) is generally distributed among most enzymes of the pathway. The aim of this thesis was to increase the production of sterols, part of the isoprenoid class of secondary metabolites, in tobacco (Nicotiana tabacum) Bright Yellow 2 (BY-2) cell cultures. This was achieved by genetically engineering
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16

Morgan, Megan Jayne. "Identification of molecular-genetic determinants of quality traits of tomato fruit." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:662d8b1e-70cf-44fb-9ed3-46dcacc39bad.

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Tomato is an important food crop and a model for fleshy fruit development. The process of fruit ripening involves changes in chemical composition and in particular the accumulation of sugars, organic, amino acids and carotenes. The research described in this thesis aimed to identify key regulatory aspects associated with the accumulation of the major acids in tomato fruit by analysis of introgression lines resulting from a cross between a cultivated variety, Solanum lycopersicum, and a wild progenitor species, Solanum pennellii. Line 2-5 showed increases in citrate, malate, aspartate and gluta
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17

Jeremias, Juliana Toloi [UNESP]. "Balanço de macroelementos da dieta e supersaturação relativa da urina para oxalato de cálcio, equilíbrio ácido-básico e metabolismo ósseo de gatos adultos." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/101269.

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Made available in DSpace on 2014-06-11T19:31:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-29Bitstream added on 2014-06-13T19:20:18Z : No. of bitstreams: 1 jeremias_jt_dr_jabo.pdf: 528083 bytes, checksum: c1b4c329fed1bd4561479bb87139f6b5 (MD5)<br>A composição mineral da dieta influencia as características da urina de gatos, estando envolvida no desenvolvimento e prevenção de urolitíases. Diante disso, em um primeiro experimento, foram investigados os efeitos da manipulação mineral da dieta baseada em seu excesso de bases sobre excreção urinária de macroelementos e supersaturaç
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18

Jeremias, Juliana Toloi. "Balanço de macroelementos da dieta e supersaturação relativa da urina para oxalato de cálcio, equilíbrio ácido-básico e metabolismo ósseo de gatos adultos /." Jaboticabal, 2013. http://hdl.handle.net/11449/101269.

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Orientador: Áulus Cavalieri Carciofi<br>Banca: Áureo Evangelista Santana<br>Banca: Márcia Mery Kogika<br>Banca: Ricardo Souza Vasconcellos<br>Banca: Márcio Antônio Brunetto<br>Resumo: A composição mineral da dieta influencia as características da urina de gatos, estando envolvida no desenvolvimento e prevenção de urolitíases. Diante disso, em um primeiro experimento, foram investigados os efeitos da manipulação mineral da dieta baseada em seu excesso de bases sobre excreção urinária de macroelementos e supersaturação relativa da urina para oxalato de cálcio (SSR OxCa). Em uma dieta basal (EB=3
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19

Muir, Jacqueline M. "Citrate synthase from the hyperthermophilic archaeon, Pyrococcus furiosus." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260247.

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20

GOUPRY, STEPHANE. "Etude par spectrometrie de masse de rapport isotopique du 1 3c du co-metabolisme citrate-glucose chez une bacterie lactique." Nantes, 2001. http://www.theses.fr/2001NANT2009.

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Le laboratoire d'analyses isotopique et electrochimique de metabolismes (l. A. I. E. M. ) a developpe une expertise dans l'etude de la filiation isotopique liant le produit d'une transformation biologique a son substrat d'origine. Soucieux d'eprouver et de developper nos methodes analytiques, nous desirons etudier les filiations isotopiques entre deux substrats et plusieurs produits. Nous avons choisi l'etude du co-metabolisme citrate-glucose chez une bacterie lactique : lactococcus lactis subsp. Lactis biovar. Diacetylactis comme modele d'etude. Ce choix nous a conduit a developper le dosage
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21

Siqueira, Joseilma Luciana Neves. "Alterações estruturais e metabólicas induzidas por citrato em células tumorais (MCF-7) e não tumorais (Fibroblastos) in vitro." reponame:Repositório Institucional da UnB, 2016. http://repositorio.unb.br/handle/10482/22156.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Biologia Animal, 2016.<br>Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-12-07T15:22:29Z No. of bitstreams: 1 2016_JoseilmaLucianaNevesSiqueira.pdf: 1993383 bytes, checksum: d248e5f32657dc21ac1e7c6391b2837f (MD5)<br>Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2017-01-10T21:37:53Z (GMT) No. of bitstreams: 1 2016_JoseilmaLucianaNevesSiqueira.pdf: 1993383 bytes, checksum: d248e5f32657dc21ac1e7c6391b2837f (MD5)<br>Made available
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Hudson, Erica M. "Determining the usefulness of aerobic and anaerobic enzyme assays as proxies for rockfish ecological data." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002750.

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23

Baracat, Emílio Carlos Elias 1959. "Esvaziamento gastrico de uma solução de citrato de sodio em ratos com acidose metabolica induzida por cloreto de amonio." [s.n.], 1991. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308879.

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Orientador: Edgard Ferro Collares<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-07-14T00:40:15Z (GMT). No. of bitstreams: 1 Baracat_EmilioCarlosElias_M.pdf: 3273030 bytes, checksum: 6f36ccaa3ec57fac09a7152c14d401c1 (MD5) Previous issue date: 1991<br>Resumo: O objetivo do presente trabalho foi estudar um modelo de desidratação por privação de água e o esvaziamento gástrico de líquidos em ratos desidratados. Foram utilizados ratos Wistar (n=380) para o estudo de um modelo de privação de água (n=80) e para o estu
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24

Soares, Andressa Heimbecher. "Hipogonadismo associado à obesidade: efeitos do tratamento com citrato de clomifeno." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-13062018-074535/.

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INTRODUÇÃO: A obesidade é uma das causas de hipogonadismo (HG) secundário no homem. A terapia de reposição padrão de testosterona (TRT) é associada à melhora dos parâmetros metabólicos, mas pode levar à infertilidade. Apenas recentemente indicou-se que não há novas evidências nível 1 para apoiar uma conexão definitiva entre TRT e eventos cardiovasculares (CV). OBJETIVO: Avaliar os efeitos do Citrato de Clomifeno (CC) em homens jovens com hipogonadismo associado à obesidade diagnosticado por testosterona total (TT) <= 300 ng/dL em duas ocasiões, sintomas positivos no questionário ADAM, hormônio
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DeMoranville, Kristen J. "CHARACTERIZATION AND MOLECULAR REGULATION OF METABOLIC AND MUSCLE FLEXIBILITY IN A NEOTROPICAL MIGRANT, DUMETELLA CAROLINENSIS (GRAY CATBIRD)." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1435874292.

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26

Silva, Júlio César Rodrigues Lopes. "Produção de biomassa, análise sensorial de chás, caracterização química do óleo essencial por cromatografia gasosa uni e bidimensional abrangente de clones selecionados de Lippia alba (Mill.) N. E. Br quimiotipo citral /." Botucatu, 2019. http://hdl.handle.net/11449/181545.

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Orientador: Marcia Ortiz Mayo Marques<br>Banca: Beatriz Helena Lameiro de Noronha Sales Maia<br>Banca: Filipe Pereira Giardini Bonfim<br>Resumo: Lippia alba (Mill.) N.E.Br, pertencente à família Verbenaceae é uma planta medicinal amplamente distribuída na América do Sul. A composição química do óleo essencial da espécie, a qual derivam suas propriedades terapêuticas mostra-se variável, com divisão em quimiotipos. Entre eles, o quimiotipo citral destaca-se pelas ações calmante e ansiolítica, sendo suas folhas empregadas na medicina popular na forma de chá. Dessa forma, visando o potencial uso e
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27

Ecelbarger, Carolyn Mary. "Effects of aging, dietary citrate, kidney function and tissue turnover on aluminum metabolism in rats." 1992. http://catalog.hathitrust.org/api/volumes/oclc/28738985.html.

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28

Ross, Kerry Lynn. "Iron regulation of mitochondrial aconitase synthesis : a role for iron regulatory proteins (IRP) in cellular citrate metabolism /." 2002. http://www.library.wisc.edu/databases/connect/dissertations.html.

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29

Davies, Rhiannon. "Allometric Scaling in Centrarchid Fish: Origins of Intra- and Inter-specific Variation in Oxidative and Glycolytic Enzyme Levels in Muscle." Thesis, 2007. http://hdl.handle.net/1974/897.

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The influence of body size on metabolic rate, muscle enzyme activities, and the underlying patterns of mRNA for these enzymes were explored in an effort to explain the genetic basis of allometric variation in metabolic enzymes. Two pairs of sister species of centrarchid fishes were studied: black bass (largemouth bass, Micropterus salmoides and smallmouth bass, Micropterus dolomieui), and sunfish (pumpkinseed, Lepomis gibbosus and bluegill, Lepomis macrochirus). The goal was to assess the regulatory basis of both intraspecific and interspecific variation in relation to body size, as well as ga
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Sienkiewicz-Porzucek, Agata [Verfasser]. "Evaluation of the role of mitochondrial citrate synthase, mitochondrial and cytosolic isoforms of isocitrate dehydrogenase in tomato leaf metabolism / von Agata Sienkiewicz-Porzucek." 2009. http://d-nb.info/1002453992/34.

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Cikánková, Tereza. "Vliv psychotropních látek na mitochondriální funkce." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-437212.

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Psychopharmaca are a large group of drugs widely used not only in psychiatry. Their systemic administration affects both the main diagnosis and the organism as a whole. The subject of our experiments is the effect of psychopharmaca on the changes in mitochondrial functions, which is beneficial for understanding of molecular mechanisms of therapeutic and adverse effects of drugs. The aim of this thesis was to study the in vitro effects of selected drugs on the cell energy metabolism. Selected antipsychotics (chlorpromazine, levomepromazine, haloperidol, risperidone, ziprasidone, zotepine, aripi
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Guay, Claudiane. "Étude de l'implication des navettes du pyruvate découlant du métabolisme mitochondrial du glucose dans la régulation de la sécrétion d'insuline par les cellules bêta pancréatiques." Thèse, 2010. http://hdl.handle.net/1866/3614.

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Le diabète est une maladie métabolique qui se caractérise par une résistance à l’insuline des tissus périphériques et par une incapacité des cellules β pancréatiques à sécréter les niveaux d’insuline appropriés afin de compenser pour cette résistance. Pour mieux comprendre les mécanismes déficients dans les cellules β des patients diabétiques, il est nécessaire de comprendre et de définir les mécanismes impliqués dans le contrôle de la sécrétion d’insuline en réponse au glucose. Dans les cellules β pancréatiques, le métabolisme du glucose conduit à la production de facteurs de couplage métabol
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Yu, Hsiang-Fu, and 游象富. "Effect of lemongrass oil and citral on metabolism and toxicity of acetaminophen in rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/2k68jj.

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