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Dissertations / Theses on the topic 'Civilization specificity of activity'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Dorr, Brent Matthew. "Directed Evolution of Sortase Activity and Specificity." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11360.

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Nature employs complex networks of protein-tailoring enzymes to effect the post-translational modification of proteins in vivo. By comparison, modern chemical methods rely upon either nonspecific labeling techniques or upon the genetic incorporation of bioorthogonal handles. To develop truly robust bioconjugates it is necessary to develop methods which possess the exquisite activity and specificity observed in biological catalysts. One attractive strategy to achieve this is the engineering of protein-tailoring enzymes possessing user-defined specificity and high catalytic efficiency.<br>Che

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2

Tao, Huizhong W. "Spatial specificity of activity-induced synaptic potentiation /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9984811.

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3

Addington, Trevor. "Engineering carbohydrate-active enzymes: specificity and activity remodeled." Doctoral thesis, Universitat Ramon Llull, 2009. http://hdl.handle.net/10803/9285.

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To understand and modify the secondary cell walls of plants the project group Enzyme Discovery in Hybrid Aspen for Fiber Engineering (EDEN) was founded composed of nine laboratories with funding from the European Commission. The main target of EDEN´s research is to genetically engineer fiber structure in order to produce transgenic trees with modified properties for the pulp and paper industries. <br/>In this target framework, the Populus tremula x tremuloides xyloglucan endotransglycosylase (PttXET16A) was selected for in-depth study of its transglycosylase activity catalyzing cleavage and

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4

Mattatall, Fiona M. "Disintegrin purification and characterization by biological activity and specificity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq24683.pdf.

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5

Chosed, Renee Joanna. "Biochemical characterization of the activity and specificity of ULP1 family members." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=151.

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6

Lu, Lei. "Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-397-3/.

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7

Christie, Israel C. "Multivariate Discrimination of Emotion-Specific Autonomic Nervous System Activity." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/32903.

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The present study investigated autonomic nervous system (ANS) patterning during experimentally manipulated emotion. Film clips previously shown to induce amusement, anger, contentment, disgust, fear, and sadness, in addition to a neutral control, were presented to 34 college-aged subjects while electrodermal activity, blood pressure and electrocardiogram (ECG) were recorded as was self-reported affect. Mean and mean successive difference of inter-beat interval were derived from the ECG. Pattern classification analysis revealed emotion-specific patterning for all emotion conditions except disgu

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8

Müller, Paul Markus [Verfasser]. "Temporal and Spatial Regulation of Rho GTPase Activity and Specificity / Paul Markus Müller." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1196803080/34.

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9

Selner, Nicholas. "PROFILING THE INTRINSIC SEQUENCE SPECIFICITY OF PROTEIN TYROSINE PHOSPHATASES." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1384269733.

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10

deGroot, Rens. "The role of the Metalloprotease and Disintegin-like domains in ADAMTS13 activity and specificity." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508488.

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11

Cox, Matthew George. "Theoretical and psychometric specificity of self-regulation for physical activity: Validating measures of self-regulation." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/38832.

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Physical activity (PA) has been shown to be an important component in preventing a number of negative health outcomes and in improving cardio respiratory fitness. However, there is little consensus as to what mediates the relationship between PA interventions and PA behaviors. Numerous studies have identified self-regulation as a proximal mediator of PA interventions, but there appears to be little consensus as to what constitutes self-regulation and how it should be measured. The current study explores the theoretical underpinnings of self-regulation from several different theories and ident

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12

Jang, Geeng-Fu. "Characterization, partial purification, and substrate specificity studies of the mammalian prenyl protein-specific endoprotease activity /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8667.

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13

Karkehabadi, Saeid. "Structure-function studies of ribulose-1,5-bisphosphate carboxylase/oxygenase : activation, thermostability, and CO2/O2 specificity /." Uppsala : Dept. of Molecular Biology, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200528.pdf.

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14

Bashtrykov, Pavel [Verfasser], and Albert [Akademischer Betreuer] Jeltsch. "Regulation of the catalytic activity and specificity of DNA nucleotide methyltransferase 1 / Pavel Bashtrykov. Betreuer: Albert Jeltsch." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2014. http://d-nb.info/1049688880/34.

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15

Bräuer, Katharina Elisabeth Marianne [Verfasser], and Dirk [Akademischer Betreuer] Eick. "Activity and substrate specificity of bacterial and human ribosomal oxygenases / Katharina Elisabeth Marianne Bräuer ; Betreuer: Dirk Eick." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1179075765/34.

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16

Henderson, Jeremy. "Investigation of Saccharomyces cerevisiae Trm10 tRNA methyltransferase (m1G9) activity substrate specificity and essential amino acid residues for catalysis /." Connect to resource, 2009. http://hdl.handle.net/1811/37269.

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17

Vallur, Aarthy C. "Kinetic analysis of the contribution of base flipping to the substrate specificity and catalytic activity of human alkyladenine dna glycosylase." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008300.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 135 pages. Includes Vita. Includes bibliographical references.

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18

Rüben, Katharina Marta Verfasser], Walter [Akademischer Betreuer] Becker, and Ralph [Akademischer Betreuer] [Panstruga. "Novel harmine analogues and the effect on dual specificity kinase activity of DYRK1A / Katharina Marta Rüben ; Walter Becker, Ralph Panstruga." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1156629810/34.

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19

Hockings, Jennifer, Stephanie Degner, Sherif Morgan, Michael Kemp, and Donato Romagnolo. "Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene." BioMed Central, 2008. http://hdl.handle.net/10150/610112.

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INTRODUCTION:Increased estrogen level has been regarded to be a risk factor for breast cancer. However, estrogen has also been shown to induce the expression of the tumor suppressor gene, BRCA1. Upregulation of BRCA1 is thought to be a feedback mechanism for controlling DNA repair in proliferating cells. Estrogens enhance transcription of target genes by stimulating the association of the estrogen receptor (ER) and related coactivators to estrogen response elements or to transcription complexes formed at activator protein (AP)-1 or specificity protein (Sp)-binding sites. Interestingly, the BRC

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20

Rüben, Katharina Marta [Verfasser], Walter Akademischer Betreuer] Becker, and Ralph [Akademischer Betreuer] [Panstruga. "Novel harmine analogues and the effect on dual specificity kinase activity of DYRK1A / Katharina Marta Rüben ; Walter Becker, Ralph Panstruga." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1156629810/34.

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21

mamta, jaiswal [Verfasser]. "Structural and Biochemical investigation of the activity, specificity and regulation of regulators (GEFs & GAPs) of the Rho family / jaiswal mamta." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1031075119/34.

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22

Olsson, Sven Johan Gustav. "Studies of physical activity in the Swedish population." Doctoral thesis, Gymnastik- och idrottshögskolan, GIH, Björn Ekbloms och Mats Börjessons forskningsgrupp, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4309.

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Background: Cheap and effective tools for measuring patients’ physical activity (PA) level are needed. The first aim in this thesis was therefore to assess the validity of two PA -questions, and their three associated answer modes, that are used within the Swedish health care system. Sitting, light intensity PA (LIPA), and moderate and vigorous intensity PA (MVPA), are associated with health and longevity, but detailed population data assessed with objective methods is needed. The second aim was thus to assess the above with motion sensor technology, in a middle-aged Swedish sample. Low self-p

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23

Melzer, Susanne, Christian Sonnendecker, Christina Föllner, and Wolfgang Zimmermann. "Stepwise error-prone PCR and DNA shuffling changed the pH activity range and product specificity of the cyclodextrin glucanotransferase from an alkaliphilic Bacillus sp." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172353.

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Cyclodextrin glucanotransferase (EC 2.4.1.19) from the alkaliphilic Bacillus sp. G-825-6 converts starch mainly to c-cyclodextrin (CD8). A combination of error-prone PCR and DNA shuffling was used to obtain variants of this enzyme with higher product specificity for CD8 and a broad pH activity range. The variant S54 with seven amino acid substitutions showed a 1.2-fold increase in CD8-synthesizing activity and the product ratio of CD7:CD8 was shifted to 1:7 compared to 1:3 of the wild-type enzyme. Nine amino acid substitutions of the cyclodextrin glucanotransferase were performed to generate t

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24

Puvvada, Madhu. "Investigation into the relationship between DNA-binding affinity, sequence-specificity and biological activity in the pyrrolo[2,1-c][1,4] benzodiazepine group of antitumour antibiotics." Thesis, University of Portsmouth, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306952.

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25

Campuzano, Iain David Grant. "Substrate specificity of the polyketide synthase 6-methylsalicylic acid synthase multienzyme complex isolated from Penicillium patulum and investigation of its malonyl-CoA decarboxylase activity." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285883.

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26

Shafqat, Naeem. "Substrate specificities and functional properties of human short-chain dehydrogenases/reductases /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-829-7.

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27

Hildebrandt, Petra. "A highly stereoselective recombinant alcohol dehydrogenase aus from Pseudomonas fluorescens DSM50106 biochemical characterization, substrate specificity, enantioselectivity, and a new flow through polarimetry based dehydrogenase activity assay /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=984389296.

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28

Robinson, Margaret Reybold. "I: Enhanced specificity for aromatics using 2E mass spectrometry II: Evaluation of the proteolytic activity of cathepsin G and elastase upon bacterial cell wall III: Hydrolysis studies of an isocoumar." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/30968.

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29

Suh-Lailam, Brenda Bienka. "Development of Novel Methods and their Utilization in the Analysis of the Effect of the N-terminus of Human Protein Arginine Methyltransferase 1 Variant 1 on Enzymatic Activity, Protein-protein Interactions, and Substrate Specificity." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/863.

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Protein arginine methyltransferases (PRMTs) are enzymes that catalyze the methylation of protein arginine residues, resulting in the formation of monomethylarginine, and/or asymmetric or symmetric dimethylarginines. Although understanding of the PRMTs has grown rapidly over the last few years, several challenges still remain in the PRMT field. Here, we describe the development of two techniques that will be very useful in investigating PRMT regulation, small molecule inhibition, oligomerization, protein-protein interaction, and substrate specificity, which will ultimately lead to the advance

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30

Warshamana, Gnana Sakuntala. "Interactions of T7 RNA polymerase with its promoters : Part I: T7 promoter contacts essential for promoter activity in vivo ; Part II: Isolation and characterization of a mutant T7 RNA polymerase with altered promoter specificity." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/26303.

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31

Schönfeld, Regine Margarete. "Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of Two Human Endogenous Retrovirus Long Terminal Repeats = Untersuchungen zur Promotor-Aktivität und -Spezifität von zwei Long Terminal Repeats humaner endogener Retroviren in transgenen Mäusen." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-9017.

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32

Layer, Liliana Elisabeth [Verfasser], Rolf [Gutachter] Marschalek, and Gerald G. [Gutachter] Schumann. "Regulation of human LINE-1 activity and integration specificity by L1-EN mutations, DSB repair proteins and the application of the Tet/Dox-inducible eypression system / Liliana Elisabeth Layer ; Gutachter: Rolf Marschalek, Gerald G. Schumann." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1124539727/34.

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33

Palmqvist, Emma. "Mutagenesis of the sugar donor site of the Arabidopsis thaliana glycosyltransferase UGT72B1." Thesis, Linköpings universitet, Biokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66483.

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The Arabidopsis thaliana glycosyltransferase UGT72B1 is one of many enzymes which catalyze the reaction oflinking a glucose moiety from UDP-glucose to an acceptor molecule, in this case a chloroaniline or a chlorophenol. This is part of a detoxification system of the plant cell, similar to that in humans where a glucuronosyltransferases are enabling drug metabolism. It would be of interest to investigate the activity of the human enzyme towards different pharmaceuticals and determine the effect the linkage of glucose has to properties of the compounds. However, the human enzymes are membrane p

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34

Michielan, Lisa. "Advance Methodologies in Linear and Nonlinear Quantitative Structure-Activity Relationships (QSARs): from Drug Design to In Silico Toxicology Applications." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422242.

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Novel computational strategies are continuously being demanded by the pharmaceutical industry to assist, improve and speed up the drug discovery process. In this scenario chemoinformatics provide reliable mathematical tools to derive quantitative structure-activity relationships (QSARs), able to describe the correlation between molecular descriptors and various experimental profiles of the compounds. In the last years, nonlinear machine learning approaches have demonstrated a noteworthy predictive capability in several QSAR applications, confirming their superiority over the traditional linear

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35

Ruffet, Marie-Line. "Étude biochimique et moléculaire des sérine acétyltransférases de la cellule végétale." Grenoble 1, 1995. http://www.theses.fr/1995GRE10083.

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Le but de ce travail a consiste a caracteriser sur les plans biochimique et moleculaire la serine acetyltransferase (sat). Cette enzyme est impliquee dans la synthese de la cysteine chez les plantes superieures. L'etude de la localisation intracellulaire de l'activite sat dans les tissus photosynthetiques a permis d'etablir que la cellule vegetale renferme au moins trois isoformes de sat distinctes localisees dans le chloroplaste, la mitochondrie et le cytosol. Cette compartimentation suggere que la synthese de la cysteine pourrait se derouler dans ces trois compartiments. L'isoforme chloropla

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36

Plantier, Jean-Luc. "La thrombine dans la physiopathologie vasculaire : une étude structure-fonction." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10179.

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La thrombine est une glycoproteine de la famille des proteases a serine. Comparee a celles des autres membres de sa famille, sa structure tertiaire possede une serie de boucles d'insertion particulierement exposees, organisees autour du site actif. Parce que la specificite restreinte de la thrombine pour ses substrats semble faire appel a des interactions a la surface de la molecule, il nous est apparu interessant de determiner quels etaient les roles de ces boucles dans certaines des activites de l'enzyme. Des mutations ponctuelles ont ete realisees dans deux de ces boucles (la boucle b et la

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37

Ducourneau, Christine. "Isolement et etude d'effets physiologiques d'une toxine produite par xanthomonas campestris pv. Vasculorum, agent de la gommose de la canne a sucre." Toulouse 3, 1986. http://www.theses.fr/1986TOU30233.

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Xanthomonas campestris pv. Vasculorum produit in vivo une phytotoxine tres hydrophile. L'ensemble de ce travail a consiste a: isoler et purifier cette toxine, apporter des informations sur sa structure et nature chimique, mettre en evidence sa specificite d'interaction vis-a-vis d'une molecule affine presente chez les plantes hotes; les effets physiologiques qu'elle induit dans les cellules de l'hote. Ces derniers resultats contribuent a mieux approcher son mecanisme biochimique d'action qui se manifeste sur les hotes potentiels, a des niveaux d'organisation differents (tissu foliaire et proto

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38

Shaw, Mark. "Content Specificity of the Contralateral Delay Activity." Thesis, 2013. http://hdl.handle.net/1807/42919.

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The neural signature and cognitive architecture of how a visual stimulus reaches conscious awareness have not been conclusively determined. Recently, we have reported an ERP activity corresponding with a period of perceptual persistence which has been typically reported in working memory research, known as the contralateral delay activity (CDA). Specifically, we reported how the CDA can be used to track how on object fades in out of consciousness. Here, we report on the behaviour of the CDA when the type of item in this paradigm is manipulated between face, animal and object stimuli. We record

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39

Chung, Hsiao-Yu, and 鍾筱妤. "Optimization of activity and specificity for siRNA design." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99798552563601111263.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>100<br>Small interfering RNAs (siRNAs), which participate in post-transcriptional gene silencing, has already become a useful tool in genetic studies. Although programs are available for designing siRNA, it is still not sure to produce an ideal siRNA with high efficacy and specificity. Studies have shown that using Dicer-substrate RNAs (DsiRNAs), e.g. 25/27-mer siRNA, elevate inhibition ability. And adding 2’-O-methyl group to the second nucleotide in the seed region of guide strand eliminates miR-like off-target effect. Here, we designed L-/ R-form DsiRNAs and s

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40

Lyons, MR, and AE West. "Mechanisms of specificity in neuronal activity-regulated gene transcription." Thesis, 2011. http://hdl.handle.net/10161/5425.

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The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary advantage. Neurons convert environmental stimuli into long-lasting changes in their physiology in part through the synaptic activity-regulated transcription of new gene products. Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways th

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41

Richter, Grace Yukiko. "Molecular characterization of specificity and activity of the transposable element IS801." Thesis, 1995. http://hdl.handle.net/1957/34682.

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1S801 is a transposable element isolated from Pseudomonas syringae pathovar (pv.) phaseolicola, the causal agent of halo blight of bean. Fragments of the element are present in multiple copies on an indigenous plasmid, pMMC7105, of strain LR781, and have been implicated as sites of homologous recombination leading to imprecise excision of the chromosomally integrated form of the plasmid. The element, which has been completely sequenced, is 1512 base pairs in length and is unusual among transposable elements in that it does not have direct or inverted repeats in its termini. The terminal region

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42

NATALI, ERIBERTO NOEL. "Synergic complement-mediated bactericidal activity of monoclonal antibodies with distinct specificity." Doctoral thesis, 2018. http://hdl.handle.net/2158/1148701.

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43

Davison, Jordan Clea. "Can you handle this?: Motor activity, preference, and the body specificity hypothesis." 2013. http://hdl.handle.net/2152/21499.

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According to the Body-Specificity Hypothesis, experiences of habitual motor fluency cause people to associate positive valence with their dominant hand side and confer positive valence to items located on their dominant hand side (Casasanto, 2009). Can ongoing motor experience impact this association in the absence of visually lateralized stimuli? In Experiment 1, participants flipped cards using one hand and rated the image on each card with respect to how well it was described by positive or negative personal characteristics. Contrary to our predictions, participant’s ratings were not biased

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Lin, Hsin-Ju, and 林昕儒. "Structural Basis for the Activity and Substrate Specificity of Dopamine N-acetyltransferase." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/16256636264880671001.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>101<br>Abstract Drosophila melanogaster dopamine N-acetyltransferase (Dat, EC 2.3.1.87) is an arylalkylamine N-acetyltransferase (AANAT) which catalyzes the synthesis of the hormonal precursor (melatonin). The structures of Dat both in the apo form and in complexed with acetyl coenzyme A and the catalytic mechanism have been solved in our laboratory. In this study, we report the crystal structure of Dat ternary complex with coenzyme A and serotonin at 1.20 Å resolution. According to our structure, we proposed that three aromatic residues (F43, Y64, and F114) in

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Li, Ya-Han, and 李亞翰. "Improving the catalytic activity and altering the substrate specificity of Bacillus subtilis Lipase." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/69676507013933407660.

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碩士<br>國立臺灣師範大學<br>生命科學系<br>103<br>B. subtilis lipase (BSL) has been used in the fields of food, laundry, leather, and waste oil processing, etc. Mature form of BSL (mBSL), as the smallest lipase, is composed of 181 amino acid residues. It is an alkalophilic lipase with an optimal pH of 10. However, it is not thermostable with an optimal temperature of 35℃, and only shows higher activity on glycerol ester substrates with short to medium chain-length fatty acids. Lipase from Archaeoglobus fulgidus (AFL) has been proved to be a hyperthermophilic and alkalophilic enzyme with a optimal pH and tempe

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Huang, Yung-Hsuan, and 黃詠宣. "Development of activity-based probes with high specificity for protein tyrosine phosphatase subfamilies." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/01859176240574305041.

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碩士<br>臺灣大學<br>化學研究所<br>98<br>Protein tyrosine phosphatases (PTPs) play an important role in regulatory signal transduction. It’s a prospective contribution to realize the activities and distribution of PTP subfamilies for the studies of biomedicine. Herein we synthesize phosphotyrosine mimic device which applies for combinatorial solid phase synthesis with Fmoc strategy. Via change two positions of the designed sequence with seven different amino acids to build up the activity-based probe library of the linear and cyclic peptides. Finally we compare to the different labeling efficiency of two

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Wu, Bo-Shin, and 吳博新. "Nucleotide substrates specificity of the enzymatic activity from phosphodiesterase (PDE) in Naja atra (Taiwan cobra)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/4265y5.

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48

Agar, Nathalie Yvonne Rachel. "Identification of molecular determinants of substrate specificity and activity for biphenyl dioxygenase from Comamonas testosteroni B-356." Thesis, 2002. http://spectrum.library.concordia.ca/1841/1/NQ73337.pdf.

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The oxygenase component of biphenyl dioxygenase (BPDO) from Comamonas testosteroni B-356 dihydroxylates biphenyl and some polychlorinated biphenyls (PCBs), thereby initiating their degradation. Identification of molecular determinants for BPDO substrate selectivity and activity should allow engineering it to accept a range of chlorinated biphenyls for bioremediation. Highly active BPDO has been purified, and crystallized under anaerobic conditions. The first crystal structures of BPDO, and its substrate-bound and product-bound binary complexes, have been solved. Steady-state kinetics assays m

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Lin, Chien-Chu, and 林建竹. "The effects of integrin and heparin binding on the enzymatic activity and specificity of Taiwan cobra SVMPs." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/59884965907036020776.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>97<br>P-III type snake venom metalloproteases(SVMPs) are major enzymes with metalloprotease/disintegrin/cysteine-rich(MDC) domains in viper venom and have been implicated to disrupt the haemostatic system for the envenomed victims of viper snakebite. Recently, our laboratory identified two novel SVMPs, atragin and k-like, with similar primary sequence (~60%) and 3D structure. Atragin binds to αvβ3 integrin, inhibits NIH3T3 cell migration and possesses heparin binding ability. However, the binding model of atragin/αvβ3 integrin and the role of heparin binding on

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Chiu, Yu-An, and 邱鈺安. "Research of substrate specificity and a quick colorimetric activity assay method of UDP-glycosyltransferase from Bacillus cereus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/22122637940286054559.

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Abstract:

碩士<br>國立交通大學<br>應用化學系分子科學碩博士班<br>99<br>Glycosyltransferases have many important biological functions in all species and in the use of disease treatment. Thus we need a real time and high-throughput method to analyze glycosyltransferase activity. In this research, we focus on the UDP-glycosyltransferase from Bacillus cereus (BcGT-1) catalytic reaction. BcGT-1 was successfully over-expressed in E. coli BL21 (DE3) and purified by DEAE column. In this research, we use a quick colorimetric activity assay for glycosyltransferase BcGT-1. The assay principle is based on the glycosylation activity of B

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