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Journal articles on the topic 'Claisen Schmidt condensation reaction'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Adabella, Eunike, Cindy A. W. Oei, Vania A. Rantetasak, Tutuk Budiati, and Ami Soewandi. "Microwave-Assisted Synthesis of Bis-(Hydroxybenzylidene)-Cycloalkanones via Acid Catalyzed Claisen-Schmidt Condensation." Chemistry & Chemical Technology 18, no. 3 (2024): 350–55. http://dx.doi.org/10.23939/chcht18.03.350.

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In the present study, bis-(hydroxybenzylidene)cycloalkanone derivatives were synthesized by Claisen-Schmidt condensation using cycloalkanones and arylaldehydes in the presence of HCl as an acid catalyst. The synthetic reaction was carried out under microwave irradiation. The structure of the synthesized compounds was determined by UV, IR, 1H NMR spectroscopic methods. The obtained reaction yields were not optimal due to the self-polymerization of p-hydroxybenzaldehyde in an acid solution.

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2

Chandrasekaran, Indhu, and S. Sarveswari. "Synthesis and photophysical properties of novel bis-quinolin-3-yl-chalcones." RSC Advances 14, no. 41 (2024): 30385–95. http://dx.doi.org/10.1039/d4ra04335a.

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3

Winter, Caroline, Jéssika Nunes Caetano, Anderson Barros Caixeta Araújo, et al. "Activated carbons for chalcone production: Claisen-Schmidt condensation reaction." Chemical Engineering Journal 303 (November 2016): 604–10. http://dx.doi.org/10.1016/j.cej.2016.06.058.

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4

Toledo-Flores, Susana, Roberto Portillo, Gloria Del Angel, and Ricardo Gómez. "Claisen-Schmidt condensation reaction on BaO-ZrO2 mixed oxides." Reaction Kinetics and Catalysis Letters 92, no. 2 (2007): 361–68. http://dx.doi.org/10.1007/s11144-007-5188-z.

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5

Yi, Fengping, Yanqing Peng, Gonghua Song, and Jizong Li. "Solid Phase Synthesis of Aminochalcones." Journal of Chemical Research 2005, no. 5 (2005): 311–12. http://dx.doi.org/10.3184/0308234054323931.

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6

Alrubaie, Leaqaa A., Raheem J. Muhasin та Mazin N. Mousa. "Synthesis, characterization and evaluation of antiinflammatory properties of novel α, β-unsaturated ketones". Tropical Journal of Pharmaceutical Research 19, № 1 (2020): 147–54. http://dx.doi.org/10.4314/tjpr.v19i1.22.

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Purpose: To prepare and characterize alicyclic aromatic chalcone derivatives, and study their antibiotic and anti-inflammatory properties.Methods: Claisen-Schmidt (aldol condensation) base-catalyzed condensation was used for preparation of chalcone derivatives (compounds I - IV), and the products were characterized using ultraviolet-visible spectroscopy (UV), FT-IR spectroscopy, proton nuclear magnetic resonance (1H-NMR), carbone 13CNMR and mass spectroscopy (MS). The antibacterial effect of the compounds was determined against Baci. cereus, Staph. Aureus, E. coli, and Pseudomonas Aeruginosa.

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7

Yang, Shuliang, Peipei Huang, Li Peng, et al. "Hierarchical flowerlike magnesium oxide hollow spheres with extremely high surface area for adsorption and catalysis." Journal of Materials Chemistry A 4, no. 2 (2016): 400–406. http://dx.doi.org/10.1039/c5ta08542j.

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3D hierarchical flowerlike MgO hollow spheres with extremely high surface area showed excellent adsorption properties for heavy metal ions and catalytic properties for the Claisen–Schmidt condensation reaction.

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8

Endud, Salasiah Binti, and Nadirah Zawani Binti Mohd Nesfu. "Bimetallic Basic Catalyst Comprising Niobium and Cesium Supported on MCM-48 for the Claisen-Schmidt Condensation." Advanced Materials Research 545 (July 2012): 379–84. http://dx.doi.org/10.4028/www.scientific.net/amr.545.379.

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The Claisen–Schmidt condensations stand out to be important reaction in carbon–carbon bond formation as well as in the preparation of fine chemicals and intermediates with the presence of base catalyst such as NaOH. However, only few studies concern the synthesis and catalytic activity of mesoporous silica containing bimetallic compound as catalyst for aldol condensation of bulky aldehydes. The advantages of mesoporous systems with respect to zeolites are the improved reactant accessibility to the active sites and enhanced catalyst stability. Mesoporous silica with exceedingly high surface are

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9

Zăvoianu, Rodica, Mădălina Tudorache, Vasile I. Parvulescu, Bogdan Cojocaru, and Octavian D. Pavel. "New MgFeAl-LDH Catalysts for Claisen–Schmidt Condensation." Molecules 27, no. 23 (2022): 8391. http://dx.doi.org/10.3390/molecules27238391.

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A rapid, cheap and feasible new approach was used to synthesize the Mg0.375Fe0.375Al0.25-LDH in the presence of tetramethylammonium hydroxide (TMAH), as a nontraditional hydrolysis agent, applying both mechano-chemical (MC) and co-precipitation methods (CP). For comparison, these catalysts were also synthesized using traditional inorganic alkalis. The mechano-chemical method brings several advantages since the number of steps and the energy involved are smaller than in the co-precipitation method, while the use of organic alkalis eliminates the possibility of contaminating the final solid with

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10

Singh, Gurjaspreet, Jandeep Singh, Satinderpal Singh Mangat, and Aanchal Arora. "Synthetic approach towards ‘click’ modified chalcone based organotriethoxysilanes; UV-Vis study." RSC Adv. 4, no. 105 (2014): 60853–65. http://dx.doi.org/10.1039/c4ra08724k.

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The efficient linkage of a conjugate chalcone to n-propyltriethoxysilanes via a 1,2,3-triazole is reported. The synthesis involves a Claisen–Schmidt condensation followed by a copper(i) catalyzed azide–alkyne cycloaddition (CuAAC) reaction.

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11

Kalalbandi, Veerendra Kumar A., J. Seetharamappa, and Umesha Katrahalli. "Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus." RSC Advances 5, no. 48 (2015): 38748–59. http://dx.doi.org/10.1039/c5ra02908b.

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As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.

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12

A. Yousif, Abdullah, and Ghazwan F. Fadhil. "Novel Photosynthesis of 5,8a-dichloro-2-(4- Methoxyphenyl)-8ah-chromene from Its Chalcone Isomer And Ft-ir, 1 H And 13 C Nmr Spectroscopic Investigation." Journal Of Duhok University 23, no. 2 (2020): 118–34. http://dx.doi.org/10.26682/sjuod.2020.23.2.14.

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In the presence of alcoholic alkali, the base-catalyzed aldol condensation of equimolar quantities of substituted acetophenones and aldehydes to give good yields of condensation product. This reaction is known as the Claisen-Schmidt condensation. The Trans-3-(2,6-dichlorophenyl)-1-(4-methoxyphenyl)prop- 2-en-1-one (trans 2,6-methoxy chalcone) was synthesised by Clasien Schmidt reaction, then it exposed to the Xenon lamp to prepare the 5,8a-dichloro-2-(4-methoxyphenyl)-8aH-chromene (2,6-methoxy chromene). A number of techniques were used to characterise the mentioned two products such as, thin

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13

Mardjan, Muhammad Idham Darussalam, Retno Ambarwati, Sabirin Matsjeh, Tutik Dwi Wahyuningsih, and Winarto Haryadi. "SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE." Indonesian Journal of Chemistry 12, no. 1 (2012): 70–76. http://dx.doi.org/10.22146/ijc.21374.

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Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave

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14

Sun, Ruolun, Chenhui Han, and Jingsan Xu. "A green synthesis approach toward large-scale production of benzalacetone via Claisen–Schmidt condensation." RSC Advances 12, no. 45 (2022): 29240–45. http://dx.doi.org/10.1039/d2ra05320a.

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A stirring-induced emulsion system enables 99% selectivity to the mono-condensation product of a Claisen–Schmidt reaction. The system showed good cyclic performance and can be easily scaled up to kilogram-level for the production of benzalacetone.

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15

Salem, Mohammed A., Moustafa A. Gouda, and Ghada G. El-Bana. "Chemistry of 2-(Piperazin-1-yl) Quinoline-3-Carbaldehydes." Mini-Reviews in Organic Chemistry 19, no. 4 (2022): 480–95. http://dx.doi.org/10.2174/1570193x18666211001124510.

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Abstract: This review described the preparation of 2- chloroquinoline-3-carbaldehyde derivatives 18 through Vilsmeier-Haack formylation of N-arylacetamides and the use of them as a key intermediate for the preparation of 2-(piperazin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2- (piperazin-1-yl) quinolines derivatives was explained through the following chemical reactions: acylation, sulfonylation, Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction and Kabachnik-Field’s reaction.

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16

Hayashi, Shun, Seiji Yamazoe, Kiichirou Koyasu, and Tatsuya Tsukuda. "Application of group V polyoxometalate as an efficient base catalyst: a case study of decaniobate clusters." RSC Advances 6, no. 20 (2016): 16239–42. http://dx.doi.org/10.1039/c6ra00338a.

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We demonstrated for the first time that [Nb<sub>10</sub>O<sub>28</sub>]<sup>6−</sup> exhibited base catalytic activity for aldol-type condensation reactions including Knoevenagel and Claisen–Schmidt condensation reactions.

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17

Mirjalilia, Bi Bi Fatemeh, Abddhamid Bamoniri, Masoumeh Alipour, and Mohammad Ali Karimi Zarchia. "Zr(HSO4)4/SiO2 as an Efficient Alternative Catalyst for the Claisen-Schmidt Condensation." Zeitschrift für Naturforschung B 63, no. 12 (2008): 1421–24. http://dx.doi.org/10.1515/znb-2008-1213.

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Zr(HSO4)4/SiO2 promotes the regio-, stereo- and chemoselective Claisen-Schmidt condensation of aromatic aldehydes with ketones under solvent-free conditions with improved yields. The work-up of the reaction mixture is simple, and the catalyst is easily removed from the products by simple filtration.

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18

Qi, Xiaoxia, Xirui Yan, Wencai Peng, et al. "Graphene-induced hierarchical mesoporous MgO for the Claisen–Schmidt condensation reaction." New Journal of Chemistry 43, no. 12 (2019): 4698–705. http://dx.doi.org/10.1039/c8nj05643a.

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19

Kozmík, Václav, Pavel Lhoták, Želmíra Odlerová, and Jaroslav Paleček. "Azachalcone Derivatives and Their Bis Substituted Analogs as Novel Antimycobacterial Agents." Collection of Czechoslovak Chemical Communications 63, no. 5 (1998): 698–712. http://dx.doi.org/10.1135/cccc19980698.

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Fifteen novel substituted azachalcone derivatives and their bis substituted analogs were prepared from 3,5-diacetyl-2,6-dimethylpyridine by the Claisen-Schmidt condensation. The influence of the reaction conditions on the yield of mono- and bischalcones was studied to optimize the reaction. Spectral characteristics along with preliminary results of antimycobacterial activity of selected compounds are given.

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20

Ishkov, Yurij V., Zinaida I. Zhilina, and Ludmila P. Barday. "The interaction of formylporphyrins with weak CH-acids." Journal of Porphyrins and Phthalocyanines 07, no. 11 (2003): 761–65. http://dx.doi.org/10.1142/s1088424603000938.

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A series of 2(α,β-unsaturated-γ-keto)-5,10,15,20-tetraphenylporphyrins was obtained by condensation of 2-formyl-5,10,15,20-tetraphenylporphyrin with acetone, 1,4-diacetylbenzene, 2-acetylthiophene, acetylacetone and acetophenone according to the Claisen-Schmidt reaction. The condensation product with 1,4-diacetylbenzene could react similarly with another formyl derivative – quinoxalin-6-carboxaldehyde and 2-formyl-5,10,15,20-tetraphenylporphyrin. It is shown that this reaction passes through formation of iminium salt formylporphyrin in presence of free base piperidine and perchloric acid.

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21

Alharthi, Abdulrahman I. "Efficient Catalytic Performance of Calcined Tungstophosphoric Acid for the Claisen-Schmidt Condensation under Solvent-Free Reaction." Asian Journal of Chemistry 31, no. 11 (2019): 2579–84. http://dx.doi.org/10.14233/ajchem.2019.22219.

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Effect of calcination of tungstophosphoric acid catalyst was evaluated in terms of the synthesis of chalcone derivatives via Claisen-Schmidt condensation using the reaction of acetophenone and several substituted aldehydes. The catalyst was characterized before and after calcination by FT-IR to assess the effectiveness of the synthesis of the desired products. The calcined tungstophosphoric acid catalyst (HPW-CL) showed a better performance and high yield of Claisen-Schmidt products in a short period of time. It was also found out that the calcined tungstophosphoric acid provides a chemo selec

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22

V. Kanchana, L. Mayavan, A. Kistan, and S. Mohan. "SPECTRAL ELUCIDATION, ANTIMICROBIAL AND ANTIOXIDANT STUDY OF NEWLY SYNTHESIZED PYRAZOLINE DERIVATIVES." RASAYAN Journal of Chemistry 17, no. 01 (2024): 281–87. http://dx.doi.org/10.31788/rjc.2024.1718720.

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The preparation of Chalcones and Pyrazoline derivatives from different aromatic ketones and substituted aldehydes is detailed. Chalcones were produced by reacting aldehydes with substituted aromatic ketones, such as acetophenones, in the Claisen-Schmidt condensation reaction. Cyclohexenone derivatives are produced when ethyl aceto aromatic ketones undergo base-catalyzed cyclo-condensation to Chalcones under microwave radiation. The synthesized compounds are characterized using spectrum techniques from 1H NMR, 13C NMR, and IR. These are examined for their antioxidant qualities as well as their

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23

Rathod, Seema P., and Awinash S. Chavan. "Design and Synthesis of Flavonoid Derivatives as Anti-inflammatory Drug." Der Pharma Chemica 15, no. 6 (2023): 5. https://doi.org/10.5281/zenodo.13353509.

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A series of 2-(3’-aminesubstituted)-7-hydroxyl-4H-1-benzopyran-4-one amine derivatives has been synthesized on the basis of molecular docking results. The novel derivatives prepared by condensation of 2,4-Dihydroxyacetophenonee (1.40 ml) and 3-chlorobenzaldehyde (0.01 mole) through Claisen-Schmidt condensation reaction. Novel flavone derivatives were access for anti-inflammatory activity by using carrageenan induced rat paw edema method. Among the synthesized compounds (t, v, w, k) shows good anti-inflammatory activity comparable to reference drug (Celecoxib).

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24

Rathod, Seema P., and Awinash S. Chavan. "Design and Synthesis of Flavonoid Derivatives as Anti-inflammatory Drug." DER PHARMA CHEMICA 15, no. 6 (2023): 5. https://doi.org/10.4172/0975-413X.15.6.146-150.

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A series of 2-(3’-aminesubstituted)-7-hydroxyl-4H-1-benzopyran-4-one amine derivatives has been synthesized on the basis of molecular docking results. The novel derivatives prepared by condensation of 2,4-Dihydroxyacetophenonee (1.40 ml) and 3-chlorobenzaldehyde (0.01 mole) through Claisen-Schmidt condensation reaction. Novel flavone derivatives were access for anti-inflammatory activity by using carrageenan induced rat paw edema method. Among the synthesized compounds (t, v, w, k) shows good anti-inflammatory activity comparable to reference drug (Celecoxib).

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25

Trilleras, Jorge, Jairo Quiroga, and Angelina Hormaza. "Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method." Molbank 2022, no. 1 (2022): M1341. http://dx.doi.org/10.3390/m1341.

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The synthesis and structural diversification of N-heterocycles systems have attracted much attention because of their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen–Schmidt condensation reactions, generated the respective enones. The enones were used as electron-deficient olefins in a “formal” [2+3] cycloaddition reaction using p-tosylmethyl isocyanide—TosMIC 7. This protocol allows access to 3-(substituted aroyl)-4-heteroaryl pyrrole derivatives by the Van Leusen method.

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26

Ana, POPUȘOI. "STUDY OF THE SYNTHESIS METHODS OF 1,3-ARYL(HETERYL)PROPENONE." STUDIA UNIVERSITATIS MOLDAVIAE Științe Reale și ale Naturii, no. 6(156) (2022): 159–71. https://doi.org/10.5281/zenodo.7445813.

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In this work, we refer to the study of recent specialized literature, where some syntheses methods of chalcone derivatives are described. These substances show a very pronounced anticancer activity, having a protective action in the cellular system. They present interest due to their biological properties, such as anti-inflammatory, antioxidant, cytotoxic and antihistamine properties, etc. These important biological properties are the basis of the current research intended to obtain them synthetically. The bibliographic data refers to the synthesis of 1,3-aryl (heteryl) propenones, w

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27

Somanatha, T. M., G. Krishnaswamy, R. Bhavana, et al. "Synthesis, In Vitro and In Silico Biological Studies of 1, 2, 3-Triazole-Furan Chalcone Hybrids." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 33, no. 03 (2023): 369. http://dx.doi.org/10.59467/ijhc.2023.33.369.

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In the present investigation, we focused our interest to develop 1, 2, 3-triazolefuran chalcone hybrids along with their biological profile. The synthesis of target molecules involves sequence of reactions, namely diazotization, nucleophilic substitution, cycloaddition and finally, solvent-free Claisen–Schmidt condensation reaction. The biological profile of the synthesized compounds was carried out using prediction of activity spectra for substances and results revealed that the synthesized compounds may act as mild antimicrobial agents.

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28

Aparana Surendra Dighade. "A review: Synthesis of azachalcone and its biological activity." World Journal of Advanced Research and Reviews 25, no. 3 (2025): 1626–31. https://doi.org/10.30574/wjarr.2025.25.3.0885.

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The heterogeneous chemical potential of azachalcone has six-membered motifs containing nitrogen in the ring, leading to active research in their synthetic methodologies. This paper summarizes various methods via aldol reaction, Claisen-Schmidt condensation, molecular hybridization, environmentally trendy microwave-assisted method etc. to acquire azachalcones and their derivatives along with biological activities.

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29

Hussein, Mohammed S., Abdul Wahab J. Al-Hamdany, and Rana A. Saeed. "Synthesis and Spectral Characterization of Some New Substituted Bis-spirocyclohexanones Derived from Acetone." Science Journal of University of Zakho 6, no. 4 (2018): 155–59. http://dx.doi.org/10.25271/sjuoz.2018.6.4.548.

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Diarylidene acetones (DAA) (1-5) had been prepared by the condensation of acetone with substituted benzaldehydes via Claisen-Schmidt reaction, DAA’s brought to condense with anthrone to afford the title compounds (6-10) through Michael addition. The structures of the products were suggested in the light of spectral data (UV, IR, 1H&13C-NMR).

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30

M, Durairaj. "Chemical Synthesis of Chalcones by Claisen-Schmidt Condensation Reaction and its Characterization." International Journal for Research in Applied Science and Engineering Technology 6, no. 5 (2018): 2311–15. http://dx.doi.org/10.22214/ijraset.2018.5379.

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31

Dominguez, Carmen, Joaquín Plumet, Antoine Gaset, and Luc Rigal. "Étude des conditions de la réaction de condensation de Claisen–Schmidt de la furylméthylcétone sur le 2,5-furanedicarboxaldehyde." Canadian Journal of Chemistry 70, no. 8 (1992): 2306–9. http://dx.doi.org/10.1139/v92-290.

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The Claisen–Schmidt reaction of 2,5-furandicarboxaldehyde (FDC) with 2-acetylfuran allows for the synthesis of three products as a function of the reaction conditions. The main effects of five factors and their interaction effects on seven responses have been quantified by means of a fractional factorial design.

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32

Suwito, Hery, Ria Sari, Kautsar Ul Haq, and Alfinda Kristanti. "5-[3-(4-Bromophenyl)-1-(2,5-dimethoxyphenyl)-3-oxopropyl]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-tri-one." Molbank 2018, no. 3 (2018): M1013. http://dx.doi.org/10.3390/m1013.

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The title compound was prepared by a two-step reaction. The first step was the formation of a chalcone derivative using Claisen–Schmidt condensation, which was followed by the Michael addition of the formed chalcone with 1,3-dimethylbarbituric acid. The structure of the prepared compound was established by spectral data: FTIR, HRESIMS, 1H- and 13C-NMR.

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33

Prashant, Narayan Muskawar, Babaji Aher Sainath, and Rambhau Bhagat Pundlik. "Mild and efficient synthesis of chalcone via Claisen-Schmidt condensation reaction using dicationic benzimidazolium based ionic liquid." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 883–85. https://doi.org/10.5281/zenodo.5636650.

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Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail </em>: drprbhagat111@gmail.com Dicationic benzimidazolium based ionic liquid (IL) plays a dual role as catalyst and solvent which offers a potential candidature for conventional homogenous catalysts and solvent for Claisen-Schmidt condensation being carried out between substituted benzaldehyde and acetophenone to produce chalcones. This IL has shown good catalytic activity towards the chalcones synthesis and chalcones can simply be separated from mixtures by simple decantation of disso

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34

Wang, Qian, Xia-li Liao, Cheng Xiang, and Jian Yang. "A Practical Synthesis of the Flavone, Scutellarein." Journal of Chemical Research 41, no. 3 (2017): 157–59. http://dx.doi.org/10.3184/174751917x14873588907765.

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A practical and economical five-step synthesis of the flavone scutellarein has been achieved in 60% overall yield using the available and cheap 2,6-dimethoxy-1,4-benzoquinone as starting material. The reaction sequence involved reduction to the corresponding quinol, Friedel-Crafts acetylation, Claisen-Schmidt condensation with p-methoxybenzaldehyde, cyclisation and demethylation. The procedure is operationally simple and amenable to scale-up synthesis.

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35

Abdolahi, Sahar, and Mohammad Soleiman-Beigi. "Exploring the catalytic activity of –NHSO₃H functionalized natural asphalt: a sustainable and efficient catalyst for condensation reactions in water." RSC Advances 15, no. 12 (2025): 9280–94. https://doi.org/10.1039/d5ra00870k.

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Natural asphalt sulfamic acid (NA-NHSO3H) was synthesized through the functionalization of natural asphalt (NA). The catalytic performance of NA-NHSO3H was evaluated in Knoevenagel and Claisen–Schmidt condensation reactions under mild conditions.

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36

Journal, Baghdad Science. "Synthesis and characterization of new Oxazine , Thiazine and Pyrazol derived from chalcones." Baghdad Science Journal 11, no. 2 (2014): 477–85. http://dx.doi.org/10.21123/bsj.11.2.477-485.

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In this study, chalcones were synthesis by condensing 2-acetylpyridine with aromatic aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. After that, new heterocyclic derivatives such as Oxazine, Thiazine and Pyrazol were synthesis by reaction between chalcones with urea, thiourea and hydrazine hydrate respectively scheme 1. All these compounds wrer characterization by FTIR, 1H-NMR spectroscopy and elemental analysis.

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37

Sallal, Zainab Amer. "Synthesis and characterization of new Oxazine , Thiazine and Pyrazol derived from chalcones." Baghdad Science Journal 11, no. 2 (2014): 477–85. http://dx.doi.org/10.21123/bsj.2014.11.2.477-485.

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In this study, chalcones were synthesis by condensing 2-acetylpyridine with aromatic aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. After that, new heterocyclic derivatives such as Oxazine, Thiazine and Pyrazol were synthesis by reaction between chalcones with urea, thiourea and hydrazine hydrate respectively scheme 1. All these compounds wrer characterization by FTIR, 1H-NMR spectroscopy and elemental analysis.

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38

Marwa A. Atiyah, Olfat A. Nief, and Abdulkader M. Noori. "New Pyrazolines with Imine Moiety: Synthesis, Characterization." Tikrit Journal of Pure Science 26, no. 5 (2021): 40–47. http://dx.doi.org/10.25130/tjps.v26i5.175.

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Chalcone was prepared by claisen- schmidt condensation between reaction equivalent moles from 4-amino acetophenone with thiophen -2-carboxaldehyde in presence sodium hydroxide as base, the mechanism was involved the abstraction α Proton by base from the α-carbon of the ketone to form carbanion, which attacks carbonyl of aldehyde contains no α-hydrogens to produce α-β-unsaturated ketone, Chalcone derivative used to synthesize pyrazoline derivatives by condensation with 2,4-dinitro phenyl hydrazine. The newly synthesized compounds were determined using spectroscopic methods such as FTIR, Mass sp

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K. Upadhyay, R., Megha S. Upadhyay, and S. Jain. "Synthesis and Antimicrobial Activity of 1-[2-(10-p-Chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones." E-Journal of Chemistry 6, s1 (2009): S254—S258. http://dx.doi.org/10.1155/2009/901646.

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Aiming at the development of antimicrobial agents, we have synthesized nine chlorobenzyl substituted phenothiazinyl chalcones by condensing 2-acetyl phenothiazine with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen - Schmidt condensation and subsequent reaction of products withp-chlorobenzyl bromide. Structures of these compounds were elucidated by their IR, 'H NMR spectroscopic data and microonalyses. The antimicrobial activity of the new products was evaluated by Filter Paper Disc Method.

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Gao, Lihong, Jiang Chen, Jun Zheng, and Haiyan Zhang. "Synthesis of curcumin catalyzed by KF/Al2O3." Pigment & Resin Technology 45, no. 4 (2016): 225–33. http://dx.doi.org/10.1108/prt-01-2015-0002.

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Purpose The purpose of the study reported in this paper is to synthesis curcumin, which was reported to possess broad pharmacological effects and excellent dyeing properties, via Claisen-Schmidt condensation reaction catalysed by an efficient and green solid base catalyst, KF/Al2O3. Design/methodology/approach A series of catalysts with different KF loadings and varying calcination temperatures had been prepared, characterised by Brunauer–Emmett–Taller surface area, temperature-programmed desorption with CO2 using infrared spectroscopy, X-ray powder diffraction and X-ray photoelectron spectros

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Hirani, Jayanti B., Mayank K. Pandya, and Suresh B. Koradiya. "Synthesis of Diverse Fused Tetracyclic Thiazepine-Chalcone Derivatives by Claisen-Schmidt Condensation Reaction and their Antimicrobial Activity." Asian Journal of Chemistry 32, no. 11 (2020): 2860–64. http://dx.doi.org/10.14233/ajchem.2020.22867.

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To develop antimicrobial agent, a series of thiazepine-chalcones was synthesized by Claisen-Schmidt condensation between the couplings of aryl ketone in three steps protocol and different aromatic aldehydes under strong base catalyst at room temperature. The characterization of final products were carried out by IR, 1H & 13C NMR and elemental analysis. The synthesized compounds were also evaluated for their antibacterial and antifungal activities using specific Gram positive and Gram-negative bacterial strains using cup plate method.

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Zainab Amer Sallal. "Preparation and Characterization of New Heterocyclic Derivatives, Six and Five Ring from Acetanilide." University of Thi-Qar Journal of Science 7, no. 2 (2020): 87–89. http://dx.doi.org/10.32792/utq/utjsci/v7i2.721.

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The aim of the study synthesis of new heterocyclic derivatives (six and five ring) from acetanilide. Firstly the chalcones have been synthesized from the reaction acetanilide with aromatic aldehyde [ 2-nitrobenzaldyhade, 4- dimethylaminobenzaldehyde, 2-naphthaldehyde ] in dilute solution of ethanolic sodium hydroxide at room temperature. This reaction occurs depending on Claisen Schmidt condensation, then a new oxazine and thiazine derivatives (six ring) have been synthesized by the reaction chalcones with urea and thiourea. Finally the synthesized chalcones were reacted with hydrazine hydrate

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Akbari, P. M., and V. R. Shah. "Synthesis, Characterization and Biological Evaluation of Ethyl-4'-(cyclopropane carboxamido-N-yl)-5-ary-3-oxo-3,4,5,6-tetrahydro-biphenyl-4-carboxylate." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 240–43. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p196.

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A series of new substituted cyclohexenone derivatives have been synthesized by the reaction of various substituted chalcones with ethylacetoacetate. Some new N-(4-(3-aryl-acryloyl)phenyl)cyclopropane carboxamide were prepared by Claisen-Schmidt condensation method in presence of sodium hydroxide in ethanol solvent under stirring. The synthesized compounds were characterized by their spectral (IR, NMR, Mass) data and screened for their antimicrobial activities against Gram-positive and Gram-negative bacteria by using standard antimicrobial drugs.

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Hazarkhani, Hassan, Pradeep Kumar, Kadam Sachin Kondiram, and Ikhlas M. Shafi Gadwal. "Highly Selective Claisen–Schmidt Condensation Catalyzed by Silica Chloride Under Solvent-Free Reaction Conditions." Synthetic Communications 40, no. 19 (2010): 2887–96. http://dx.doi.org/10.1080/00397910903340637.

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Dong, Fang, Cheng Jian, Fei Zhenghao, Gong Kai, and Liu Zuliang. "Synthesis of chalcones via Claisen–Schmidt condensation reaction catalyzed by acyclic acidic ionic liquids." Catalysis Communications 9, no. 9 (2008): 1924–27. http://dx.doi.org/10.1016/j.catcom.2008.03.023.

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Stoylkova, Tanya, Tsveta Stanimirova, Christo D. Chanev, Petya Petrova, and Kristina Metodieva. "Mixed Oxides as Catalysts for the Condensation of Cyclohexanol and Benzaldehyde to Obtain a Claisen–Schmidt Condensation Product." Catalysts 14, no. 7 (2024): 445. http://dx.doi.org/10.3390/catal14070445.

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Acid–base M2+MgAlO and M2+AlO mixed oxides (where M2+ = Mg, Cu, Co, Zn, and Ni) were obtained by thermal decomposition of the corresponding layered double hydroxide (LDH) precursors and used as catalysts for cyclohexanol and benzaldehyde condensation under solvent-free conditions. The catalysts were characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), and temperature-programmed desorption of CO2 (TPD-CO2). Gas chromatography–mass spectroscopy (GC/MS) was used for the identification and quantification of the product mixtures. In the reaction of

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Komala, Ismiarni, Supandi Supandi, Nurmeilis Nurmeilis, et al. "Microwave-Assisted Claisen-Schmidt Condensation Reaction of Ethyl p-methoxycinnamate to Synthesize p-Methoxystyryl Ketone Derivatives and Evaluate Anti-inflammatory Activity of Synthetic Products." Journal of Mathematical and Fundamental Sciences 53, no. 1 (2021): 86–96. http://dx.doi.org/10.5614/j.fund.math.sci.2021.53.1.6.

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The rhizome of Kaempferia galanga has been known to contain ethyl p-methoxycinnamate (EPMC) (1) as a main component, which has anti-inflammatory properties. Previously we have reported the structural modification of EPMC (1) to form another ester, nitrostyrene, and cinnammamide derivatives and then studied their structure-activity relationships as anti-inflammatory agent. In continuing our research, in this paper, we report the microwave-assisted Claisen-Schmidt condensation of EPMC (1) to synthesize a series of p-methoxystyryl ketones followed by a study of their anti-inflammatory activity. T

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Komala, Ismiarni, Supandi Supandi, Nurmeilis Nurmeilis, et al. "Microwave-Assisted Claisen-Schmidt Condensation Reaction of Ethyl p-methoxycinnamate to Synthesize p-Methoxystyryl Ketone Derivatives and Evaluate Anti-inflammatory Activity of Synthetic Products." Journal of Mathematical and Fundamental Sciences 53, no. 1 (2021): 86–96. http://dx.doi.org/10.5614/j.math.fund.sci.2021.53.1.6.

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The rhizome of Kaempferia galanga has been known to contain ethyl p-methoxycinnamate (EPMC) (1) as a main component, which has anti-inflammatory properties. Previously we have reported the structural modification of EPMC (1) to form another ester, nitrostyrene, and cinnammamide derivatives and then studied their structure-activity relationships as anti-inflammatory agent. In continuing our research, in this paper, we report the microwave-assisted Claisen-Schmidt condensation of EPMC (1) to synthesize a series of p-methoxystyryl ketones followed by a study of their anti-inflammatory activity. T

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Sapnakumari, M., K. Divya, K. B. Aswin, and J. Dalin. "Antimicrobial and Antioxidant Study of Some Newly Synthesized Chalcones and Cyclohexenone Derivatives." Asian Journal of Chemistry 35, no. 1 (2022): 114–18. http://dx.doi.org/10.14233/ajchem.2023.24057.

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Chalcones and cyclohexenone derivatives obtained from various substituted aldehydes and substituted acetophenones are described. Chalcones were obtained by the Claisen-Schmidt condensation reaction of aldehydes with substituted acetophenones. Base catalyzed cyclocondensation of ethyl acetoacetate to chalcones under microwave irradiation leads to the formation of cyclohexenone derivatives. The prepared compounds are characterized by IR, 1H NMR and 13C NMR spectral methods. These are screened for their antimicrobial activity against Staphylococcus aureus, Escherichia coli, Aspergillus niger, Asp

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Rusnac, Roman, Maria Botnaru, Nicanor Barba, Peter Petrenko, Yurii Chumakov, and Aurelian Gulea. "Compounds Removed from the Condensation Reaction between 2-acetylpyridine and 2-formylpyridine. Synthesis, Crystal Structure and Biological Evaluation." Chemistry Journal of Moldova 15, no. 2 (2020): 88–98. http://dx.doi.org/10.19261/cjm.2020.695.

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The research is devoted to the study of unexpected products that formed as a result of the condensation reaction between 2-acetylpyridine and 2-formylpyridine under the Claisen-Schmidt reaction conditions. As a result, a sequence of reactions leading to the following compounds has been proposed: 1,3-bis (pyridin-2-yl) prop-2-en-1-one (3); 1,3,5-tri (pyridin-2-yl) pentane-1,5-dione (4); (2,4-dihydroxy-2,4,6-tri(pyridin-2-yl)cyclohexyl)(pyridin-2-yl)methanone (5) and (4-hydroxy-2,4,6-tri(pyridin-2-yl)cyclohexane-1,3-diyl)bis(pyridin-2-ylmethanone) (6) as well as 2-formylpyridine (1) and 2-acetyl

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