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1

Armstrong, W. "Polarographic oxygen electrodes and their use in plant aeration studies." Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences 102 (1994): 511–27. http://dx.doi.org/10.1017/s0269727000014548.

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SynopsisThe electrolytic reduction of oxygen which occurs at a wetted ‘unattackable’ cathodic electrode of platinum or gold when polarised in conjunction with a Ag/AgCl anode, forms the basis of most polarographic oxygen measurements in plant biological work.Various types of polarographic electrode and their uses are reviewed. These include cylindrical sleeving electrodes for quantifying localised oxygen fluxes from intact roots, ‘bare’, membrane-coated, and Clark-type microelectrodes suitable for measuring concentrations and profiles both inside roots and in the rhizosphere, and macro-Clark e
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2

Suzuki, Hiroaki, Akio Sugama, and Naomi Kojima. "Micromachined Clark oxygen electrode." Sensors and Actuators B: Chemical 10, no. 2 (1993): 91–98. http://dx.doi.org/10.1016/0925-4005(93)80031-6.

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3

Barton, S. A., C. E. Hahn, and A. M. Black. "A compensation method for membrane-covered (Clark) electrodes." Journal of Applied Physiology 65, no. 3 (1988): 1430–35. http://dx.doi.org/10.1152/jappl.1988.65.3.1430.

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Membrane-covered electrodes (Clark electrodes) are widely used for monitoring blood gases, particularly PO2. A method of compensating for the inherently limited speed of response of Clark electrodes is presented. The theoretical response in the time domain is related to that in the frequency domain, and the latter is deduced from measurement of the former. Although the response functions are both infinite series, both responses are nevertheless completely defined by a single time parameter Te characteristic of the electrode under given measurement conditions. Practical verification was perform
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4

Suzuki, Hiroaki, Akio Sugama, and Naomi Kojima. "Miniature Clark-type oxygen electrode with a three-electrode configuration." Sensors and Actuators B: Chemical 2, no. 4 (1990): 297–303. http://dx.doi.org/10.1016/0925-4005(90)80157-u.

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5

CLARK, LELAND C., and ELEANOR W. CLARK. "A Personalized History of the Clark Oxygen Electrode." International Anesthesiology Clinics 25, no. 3 (1987): 1–29. http://dx.doi.org/10.1097/00004311-198702530-00004.

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6

Windle, Christopher D., Julien Massin, Murielle Chavarot-Kerlidou, and Vincent Artero. "A protocol for quantifying hydrogen evolution by dye-sensitized molecular photocathodes and its implementation for evaluating a new covalent architecture based on an optimized dye-catalyst dyad." Dalton Transactions 47, no. 31 (2018): 10509–16. http://dx.doi.org/10.1039/c8dt01210e.

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7

Ullah, Md Mahbub, Connie P. C. Ow, Lucinda M. Hilliard Krause, and Roger G. Evans. "Renal oxygenation during the early stages of adenine-induced chronic kidney disease." American Journal of Physiology-Renal Physiology 317, no. 5 (2019): F1189—F1200. http://dx.doi.org/10.1152/ajprenal.00253.2019.

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To assess whether renal hypoxia is an early event in adenine-induced chronic kidney disease, adenine (100 mg) or its vehicle was administered to male Sprague-Dawley rats by daily oral gavage for 7 days. Kidney oxygenation was assessed by 1) blood oximetry and Clark electrode in thiobutabarbital-anesthetized rats, 2) radiotelemetry in unanesthetized rats, and 3) expression of hypoxia-inducible factor (HIF)-1α and HIF-2α protein. After 7 days of treatment, under anesthesia, renal O2 delivery was 51% less, whereas renal O2 consumption was 65% less, in adenine-treated rats than in vehicle-treated
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8

Stoytcheva, Margarita, Roumen Zlatev, Mary Beleno, and Gisela Montero. "Detection of Phenolic Compounds by Tyrosinase Modified Clark Type Electrode." Current Analytical Chemistry 11, no. 1 (2014): 50–55. http://dx.doi.org/10.2174/1573411010666141119220515.

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9

Suzuki, Hiroaki. "Disposable clark oxygen electrode using recycled materials and its application." Sensors and Actuators B: Chemical 21, no. 1 (1994): 17–22. http://dx.doi.org/10.1016/0925-4005(93)01207-k.

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10

Suzuki, Hiroaki, Taishi Hirakawa, Ikutomo Watanabe, and Yuji Kikuchi. "Determination of blood pO2 using a micromachined Clark-type oxygen electrode." Analytica Chimica Acta 431, no. 2 (2001): 249–59. http://dx.doi.org/10.1016/s0003-2670(00)01325-8.

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11

Liu, Xiaoping, Qihui Liu, Era Gupta, Nicholas Zorko, Emma Brownlee, and Jay L. Zweier. "Quantitative measurements of NO reaction kinetics with a Clark-type electrode." Nitric Oxide 13, no. 1 (2005): 68–77. http://dx.doi.org/10.1016/j.niox.2005.04.011.

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12

Heyman, Samuel N., Fanny Karmeli, Daniel Rachmilewitz, Abdalla Haj-Yehia, and Mayer Brezis. "Intrarenal nitric oxide monitoring with a Clark-type electrode: Potential pitfalls." Kidney International 51, no. 5 (1997): 1619–23. http://dx.doi.org/10.1038/ki.1997.223.

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13

Pfeiffer, Silvia, Astrid Schrammel, Kurt Schmidt, and Bernd Mayer. "Electrochemical Determination ofS-Nitrosothiols with a Clark-Type Nitric Oxide Electrode." Analytical Biochemistry 258, no. 1 (1998): 68–73. http://dx.doi.org/10.1006/abio.1998.2562.

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14

Wolfbeis, Otto S. "Luminescent sensing and imaging of oxygen: Fierce competition to the Clark electrode." BioEssays 37, no. 8 (2015): 921–28. http://dx.doi.org/10.1002/bies.201500002.

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15

Al Meselmani, Mokhanad Ali, Andrey Viktorovich Yevseyev, and Petr Dmitriyevich Shabanov. "Energy metabolism in rat testis after 137Cs incorporation." Reviews on Clinical Pharmacology and Drug Therapy 11, no. 2 (2013): 41–44. http://dx.doi.org/10.17816/rcf11241-44.

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Testis tissue energy metabolism was investigated in experiments on albino rats by the polarographic method with using of Clark electrode upon 137Cs incorporation. Speed changes are revealed in all metabolic conditions such as oxidation under endogenous and exogenous substrates, uncoupling of oxidative phosphorylation, and decrease share of the fatty acids role in testicular tissue energy production.
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16

Cui, Yue, John Barford, and Reinhard Renneberg. "An Oxygen-rich Enzyme Matrix for Biosensor Construction Based on Clark Oxygen Electrode." ECS Transactions 1, no. 21 (2019): 37–44. http://dx.doi.org/10.1149/1.2218990.

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17

Kuchnicki, Ted C., and Norman E. R. Campbell. "Amperometric responses to acetylene, ethylene, and methane by a Clark-type oxygen electrode." Analytical Biochemistry 149, no. 1 (1985): 111–16. http://dx.doi.org/10.1016/0003-2697(85)90482-8.

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18

Schmidt, K., P. Klatt, and B. Mayer. "Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide." Biochemical Journal 301, no. 3 (1994): 645–47. http://dx.doi.org/10.1042/bj3010645.

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A frequently applied photometrical assay of NO is based on the reaction of NO with oxyhaemoglobin. This study shows that peroxynitrite induces spectral changes of oxyhaemoglobin identical with those elicited by NO. Like a variety of other agents, peroxynitrite did not interfere with NO measurements using a Clark-type electrode, demonstrating that electrochemical detection has an advantage over the oxyhaemoglobin method for specific determination of NO.
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19

Koeners, Maarten P., Connie P. C. Ow, David M. Russell, et al. "Telemetry-based oxygen sensor for continuous monitoring of kidney oxygenation in conscious rats." American Journal of Physiology-Renal Physiology 304, no. 12 (2013): F1471—F1480. http://dx.doi.org/10.1152/ajprenal.00662.2012.

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The precise roles of hypoxia in the initiation and progression of kidney disease remain unresolved. A major technical limitation has been the absence of methods allowing long-term measurement of kidney tissue oxygen tension (Po2) in unrestrained animals. We developed a telemetric method for the measurement of kidney tissue Po2 in unrestrained rats, using carbon paste electrodes (CPEs). After acute implantation in anesthetized rats, tissue Po2 measured by CPE-telemetry in the inner cortex and medulla was in close agreement with that provided by the “gold standard” Clark electrode. The CPE-telem
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20

Vrbová, Eva, and Miroslav Marek. "Preparation of enzyme electrode for D-glucose determination by immobilization of glucose oxidase on collagen membrane." Collection of Czechoslovak Chemical Communications 55, no. 10 (1990): 2568–74. http://dx.doi.org/10.1135/cccc19902568.

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An enzyme electrode for the determination of D-glucose was prepared by immobilization of glucose oxidase (EC 1.1.3.4.) on an activated collagen membrane using glutaraldehyde and the Ugi reaction resp. and by subsequent fixation of the membrane to an oxygen sensor of the Clark type. Two different procedures for the modification of the support, the composition of the reaction mixture and the immobilization time were examined. The electrode prepared was tested as regards the effect of pH and temperature on the magnitude of the response. The range of the linear dependence of the sensor response on
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21

Suzuki, Hiroaki, Akio Sugama, and Naomi Kojima. "Effect of anode materials on the characteristics of the miniature Clark-type oxygen electrode." Analytica Chimica Acta 233 (1990): 275–80. http://dx.doi.org/10.1016/s0003-2670(00)83488-1.

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22

Roginsky, Vitaly, and Tatyana Barsukova. "Chain-Breaking Antioxidant Capability of Some Beverages as Determined by the Clark Electrode Technique." Journal of Medicinal Food 4, no. 4 (2001): 219–29. http://dx.doi.org/10.1089/10966200152744490.

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23

Wise, Robert R., and Aubrey W. Naylor. "Calibration and use of a Clark-type oxygen electrode from 5 to 45°C." Analytical Biochemistry 146, no. 1 (1985): 260–64. http://dx.doi.org/10.1016/0003-2697(85)90424-5.

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24

Pfeiffer, S., A. Schrammel, K. Schmidt, and B. Mayer. "SENSITIVE ELECTROCHEMICAL MEASUREMENT OF LOW MOLECULAR MASS S-NITROSOTHIOLS WITH A CLARK-TYPE NO-ELECTRODE." Japanese Journal of Pharmacology 75 (1997): 111. http://dx.doi.org/10.1016/s0021-5198(19)41840-4.

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25

Sun, Yurui, Menghua Li, Qiang Cheng, et al. "Tracking oxygen and temperature dynamics in maize silage-novel application of a Clark oxygen electrode." Biosystems Engineering 139 (November 2015): 60–65. http://dx.doi.org/10.1016/j.biosystemseng.2015.08.004.

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26

Miniaev, M. V., M. B. Belyakova, N. V. Kostiuk, D. V. Leshchenko, and T. A. Fedotova. "Non-obvious Problems in Clark Electrode Application at Elevated Temperature and Ways of Their Elimination." Journal of Analytical Methods in Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/249752.

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Well-known cause of frequent failures of closed oxygen sensors is the appearance of gas bubbles in the electrolyte. The problem is traditionally associated with insufficient sealing of the sensor that is not always true. Study of a typical temperature regime of measurement system based on Clark sensor showed that spontaneous release of the gas phase is a natural effect caused by periodic warming of the sensor to a temperature of the test liquid. The warming of the sensor together with the incubation medium causes oversaturation of electrolyte by dissolved gases and the allocation of gas bubble
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27

Clark, G. M., and Robert V. Shannon. "The University of Melbourne—Nucleus Multi‐Electrode Cochlear Implant by G. M. Clark et al." Journal of the Acoustical Society of America 84, no. 6 (1988): 2298. http://dx.doi.org/10.1121/1.396992.

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28

Rodriguez-López, JoséNeptuno, JoséRamón Ros-Martínez, Ramón Varón, and Francisco García-Cánovas. "Calibration of a Clark-type oxygen electrode by tyrosinase-catalyzed oxidation of 4-tert-butylcatechol." Analytical Biochemistry 202, no. 2 (1992): 356–60. http://dx.doi.org/10.1016/0003-2697(92)90118-q.

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29

Sezgintürk, Mustafa Kemal, та Erhan Dinçkaya. "β-Galactosidase monitoring by a biosensor based on Clark electrode: Its optimization, characterization and application". Biosensors and Bioelectronics 23, № 12 (2008): 1799–804. http://dx.doi.org/10.1016/j.bios.2008.02.017.

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30

Edwards, Bradley, David Murphy, Carol Janzen, and Nordeen Larson. "Calibration, Response, and Hysteresis in Deep-Sea Dissolved Oxygen Measurements." Journal of Atmospheric and Oceanic Technology 27, no. 5 (2010): 920–31. http://dx.doi.org/10.1175/2009jtecho693.1.

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Abstract Accurately measuring the dissolved oxygen concentration in the ocean has been the subject of considerable research. Traditionally, the calibration and correction of profiling oxygen measurements has centered on static, steady-state errors, leaving dynamic or time-dependent errors in the sensor response largely untreated. This study evaluates a reengineered Sea-Bird Electronics dissolved-oxygen Clark electrode (SBE 43) and demonstrates the characterization of sensor time response over oceanographic temperatures and pressures as well as treating a time-dependent, pressure-induced effect
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31

Berkels, Reinhard, Svenja Purol-Schnabel, and Renate Roesen. "A new method to measure nitrate/nitrite with a NO-sensitive electrode." Journal of Applied Physiology 90, no. 1 (2001): 317–20. http://dx.doi.org/10.1152/jappl.2001.90.1.317.

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There are different methods to measure the unstable molecule nitric oxide (NO). We will describe a new sensitive method to measure NO by reconversion of nitrate/nitrite to NO, which will be determined with an amperometric Clark-type electrode. Nitrate and nitrite are the degradation products of NO. First, nitrate is enzymatically converted to nitrite with the use of the nitrate reductase. Second, nitrite is reduced to equimolar NO concentrations by an acidic iodide solution. The detection limit of the electrode in an aqueous solution was 2 nmol/l NO (meaning the threshold was depending on the
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32

Waffo, Armel F. T., Biljana Mitrova, Kim Tiedemann, Chantal Iobbi-Nivol, Silke Leimkühler, and Ulla Wollenberger. "Electrochemical Trimethylamine N-Oxide Biosensor with Enzyme-Based Oxygen-Scavenging Membrane for Long-Term Operation under Ambient Air." Biosensors 11, no. 4 (2021): 98. http://dx.doi.org/10.3390/bios11040098.

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An amperometric trimethylamine N-oxide (TMAO) biosensor is reported, where TMAO reductase (TorA) and glucose oxidase (GOD) and catalase (Cat) were immobilized on the electrode surface, enabling measurements of mediated enzymatic TMAO reduction at low potential under ambient air conditions. The oxygen anti-interference membrane composed of GOD, Cat and polyvinyl alcohol (PVA) hydrogel, together with glucose concentration, was optimized until the O2 reduction current of a Clark-type electrode was completely suppressed for at least 3 h. For the preparation of the TMAO biosensor, Escherichia coli
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33

Paital, B., and Luna Samanta. "A comparative study of hepatic mitochondrial oxygen consumption in four vertebrates by using Clark-type electrode." Acta Biologica Hungarica 64, no. 2 (2013): 152–60. http://dx.doi.org/10.1556/abiol.64.2013.2.2.

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34

Lei, Yu, Priti Mulchandani, Wilfred Chen, and Ashok Mulchandani. "Direct Determination ofp-Nitrophenyl Substituent Organophosphorus Nerve Agents Using a RecombinantPseudomonas putidaJS444-Modified Clark Oxygen Electrode." Journal of Agricultural and Food Chemistry 53, no. 3 (2005): 524–27. http://dx.doi.org/10.1021/jf048943t.

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35

Hsueh, Anju, Tatsuya Sato, Sunho Park, Manabu Kinoshita, and Hiroaki Suzuki. "Monitoring of the Respiratory Activity of Cells Using a Microdevice with Microfabricated Clark-Type Oxygen Electrode." ECS Meeting Abstracts MA2020-01, no. 27 (2020): 2030. http://dx.doi.org/10.1149/ma2020-01272030mtgabs.

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36

Liu, Wei, Meng Li, Ziren Luo, and Gang Jin. "Using Electrochemistry - Total Internal Reflection Ellipsometry Technique to Observe the Dissolved Oxygen Reduction on Clark Electrode." Electrochimica Acta 142 (October 2014): 371–77. http://dx.doi.org/10.1016/j.electacta.2014.07.114.

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37

Roginsky, Vitaly. "Oxidizability of cardiac cardiolipin in Triton X-100 micelles as determined by using a Clark electrode." Chemistry and Physics of Lipids 163, no. 2 (2010): 127–30. http://dx.doi.org/10.1016/j.chemphyslip.2009.10.005.

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38

Suzuki, Hiroaki, Akio Sugama, Naomi Kojima, Fumio Takei, and Kasumi Ikegami. "A miniature Clark-type oxygen electrode using a polyelectrolyte and its application as a glucose sensor." Biosensors and Bioelectronics 6, no. 5 (1991): 395–400. http://dx.doi.org/10.1016/0956-5663(91)87003-t.

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39

Leclerc, Jean-Claude. "Premières données sur l'activité photosynthétique de quelques algues subaériennes vivant en milieux très peu éclairés." Canadian Journal of Botany 63, no. 11 (1985): 1893–99. http://dx.doi.org/10.1139/b85-267.

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The photosynthetic activity of three sciaphilous algae (including two cavernicolous ones) was measured with a Clark electrode in the air, by light minus dark differences in the rates of [Formula: see text] under laboratory and near natural physical conditions. Photosynthesis versus light intensity curves showed a sharp slope at low light and a suddenly lower slope at medium intensities; this is interpretable as the Kok effect. This phenomenon is stronger with cavernicolous algae than with less sciaphilous plants. High yield activity of the three studied algae was observed only in the naturally
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40

Cui, Yue, John P. Barford, and Reinhard Renneberg. "Development of an interference-free biosensor for glucose-6-phosphate using a bienzyme-based Clark-type electrode." Sensors and Actuators B: Chemical 123, no. 2 (2007): 696–700. http://dx.doi.org/10.1016/j.snb.2006.10.004.

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41

Lee, Kyong-Hoon, Yoon-Chang Kim, Hiroaki Suzuki, Kazunori Ikebukuro, Kazuto Hashimoto, and Isao Karube. "Disposable Chemical Oxygen Demand Sensor Using a Microfabricated Clark-Type Oxygen Electrode with a TiO2 Suspension Solution." Electroanalysis 12, no. 16 (2000): 1334–38. http://dx.doi.org/10.1002/1521-4109(200011)12:16<1334::aid-elan1334>3.0.co;2-5.

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42

Suzuki, Hiroaki, Naomi Kojima, Akio Sugama, and Fumio Takei. "Development of a miniature clark-type oxygen electrode using semiconductor techniques and its improvement for practical applications." Sensors and Actuators B: Chemical 2, no. 3 (1990): 185–91. http://dx.doi.org/10.1016/0925-4005(90)85003-h.

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43

Hsueh, An-Ju, Sunho Park, Tatsuya Satoh, et al. "Microdevice with an Integrated Clark-Type Oxygen Electrode for the Measurement of the Respiratory Activity of Cells." Analytical Chemistry 93, no. 13 (2021): 5577–85. http://dx.doi.org/10.1021/acs.analchem.1c00227.

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44

Macholán, Lumír, and Jiří Slanina. "Use of inhibited enzyme electrode for estimation of PEA diamine oxidase inhibitors." Collection of Czechoslovak Chemical Communications 56, no. 7 (1991): 1545–51. http://dx.doi.org/10.1135/cccc19911545.

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A biosensor consisting of a Clark type oxygen electrode and immobilized pea diamine oxidase makes it possible amperometrically to quantify, on the basis of an inhibition effect, substrate analogues of the enzyme (aliphatic amino ketones and monoamines, aromatic diamines), some alkaloids (cinchonine, lobeline, norsedamine) and drugs (1-phenylcyclopropylamine, naphazoline). The output current signal of the inhibited bioelectrode is influenced by the thickness of the membrane and its enzyme content as well as by the sort of the substrate and oxygen concentration in the reaction medium. With most
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45

Krauß, P. L., F. Buttgereit, T. Gaber, M. Pfeiffenberger, Y. Chen, and T. Buttgereit. "AB0029 THE METABOLIC HIERARCHY OF IMMUNE PROCESSES IN HUMAN MONOCYTES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1048.2–1048. http://dx.doi.org/10.1136/annrheumdis-2021-eular.794.

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Background:At sites of inflammation, monocytes carry out specific immunological functions while facing challenging bioenergetic restrictions.Objectives:Here, we investigated the potential of human monocytes to adapt under conditions of reduced energy supply by gradually inhibiting oxidative phosphorylation (OXPHOS) under glucose free conditions.Methods:We modelled this reduced energy supply with myxothiazol, an inhibitor of mitochondrial respiration, at 0, 2 and 4 pmol/106 cells to decrease mitochondrial ATP production for 0%, 25% and 66% under glucose free conditions. For the three energy lev
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46

Boehme, Stefan, Bastian Duenges, Klaus U. Klein, et al. "Multi Frequency Phase Fluorimetry (MFPF) for Oxygen Partial Pressure Measurement: Ex Vivo Validation by Polarographic Clark-Type Electrode." PLoS ONE 8, no. 4 (2013): e60591. http://dx.doi.org/10.1371/journal.pone.0060591.

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47

Millar, J. C. "Real-Time Direct Measurement of Nitric Oxide in Bovine Perfused Eye Trabecular Meshwork Using a Clark-Type Electrode." Journal of Ocular Pharmacology and Therapeutics 19, no. 4 (2003): 299–313. http://dx.doi.org/10.1089/108076803322279363.

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48

Severinghaus, John W. "The Invention and Development of Blood Gas Analysis Apparatus." Anesthesiology 97, no. 1 (2002): 253–56. http://dx.doi.org/10.1097/00000542-200207000-00031.

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In 1953, the doctor draft interrupted Dr. Severinghaus' anesthesia and physiology training and sent him to the National Institutes of Health as director of anesthesia research at the newly opened Clinical Center. He developed precise laboratory partial pressure of carbon dioxide (PCO(2)) and pH analysis to investigate lung blood gas exchange during hypothermia. Constants for carbon dioxide solubility and pK' were more accurately determined. In August 1954, he heard Richard Stow describe invention of a carbon dioxide electrode and immediately built one, improved its stability, and tested its re
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49

Schläppy, Marie-Lise, Friederike Hoffmann, Hans Røy, et al. "Oxygen dynamics and flow patterns of Dysidea avara (Porifera: Demospongiae)." Journal of the Marine Biological Association of the United Kingdom 87, no. 6 (2007): 1677–82. http://dx.doi.org/10.1017/s0025315407058146.

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The present publication presents oxygen properties and pumping behaviour of Dysidea avara. Oxygen profiles were measured near and inside the atrial space of the osculum with a Clark-type micro-electrode. Pumping sponges had profiles with oxygen concentrations marginally lower than that of the aquarium water. In contrast, diffusive profiles, with a clear boundary layer above the sponge surface, and oxygen penetrating only 0.5 mm into the sponge tissue, were typically that of a sponge which was not pumping. Diffusive oxygen flux at the sponge surface was 4.2 μmol O2 cm2 d1 and the calculated vol
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50

Vrbová, Eva, Jitka Pecková, and Miroslav Marek. "Preparation and Utilization of a Biosensor Based on Galactose Oxidase." Collection of Czechoslovak Chemical Communications 57, no. 11 (1992): 2287–94. http://dx.doi.org/10.1135/cccc19922287.

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An enzyme electrode for D-galactose determination was prepared by fixation of a carrier with immobilized galactose oxidase (E.C. 1.1.3.9) or coimmobilized galactose oxidase and catalase (E.C. 1.11.1.6) to a Clark-type oxygen sensor. The enzymes were immobilized either on a partially hydrolyzed nylon mesh or on a native collagen membrane using the Ugi reaction with cyclohexyl isocyanide and glutaraldehyde. The biosensors were characterized by the specific activity of the immobilized galactose oxidase, the apparent Michaelis constant KM(app.), and the stability expressed by time and a number of
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