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Dhanar, Prayoga, and P. Koesrindartoto Ph.D. Deddy. "Design and Evaluation of Robo-Advisors Using Index Fund and Alternative Assets of Cryptocurrency and Gold: Case of Indonesian Capital Market." International Journal of Current Science Research and Review 05, no. 02 (2022): 390–95. https://doi.org/10.5281/zenodo.6046551.
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Abstract : Robo-advisor is one of the most prominent innovation in the wealth management industry, and its success in Indonesia has been evident in the case of Bibit. Therefore, wealth management companies need to employ Robo-Advisor to overcome their competition. This research aims to give recommendation on asset allocation method and asset class selection for Robo-Advisors in Indonesia using Sharpe Ratio Analysis. Then, the author will analyze the robo-advisor’s performance during equity market downturn. Finally, The Robo-Advisor’s actual performance will be tested in 2018, 2019, and 2020. The Sharpe ratio analysis result showed that Robo-Advisors seeking higher risk-adjusted return should choose mean-variance optimization over risk parity for asset allocation method, and the inclusion of gold and bitcoin in a portfolio of stock mutual fund and bond mutual fund increases the risk-adjusted return of the portfolio. The proposed robo-advisor’s portfolio protected investors from equity market downturn in 2011-2010 in 83,3% of the case. Finally, the proposed robo-advisor’s portfolio generated better return for the conservative, moderate and aggressive investor during 2018, 2019, and 2020 when compared to LQ45.
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Jaffé, William F., and Mary E. Huba. "Engineering Students' Use of and Satisfaction With Faculty and Professional Academic Advising Systems." NACADA Journal 10, no. 2 (1990): 37–43. http://dx.doi.org/10.12930/0271-9517-10.2.37.
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The academic advising program in a college of engineering was studied to describe the role of the advisor in terms of Predominant patterns of use for assistance with preregistration, class add/drop, curriculum planning, career guidance, college and department rules and procedures, and personal counseling. Faculty and professional advisors were compared, and student gender, grade point average (GPA), and age were studied. Students used their advisors predominantly for assislance with preregistration, curriculum planning, and adding or dropping classes. Students assigned to faculty advisors reported greater use of and satisfaction with their advisors than students assigned professional advisors. No discernable pattern of use of and satisfaction with the assigned advisor was found with regard to gender. The expectation was not generally supported that females would use and be more satisfied with their advisors than would males. Students with higher GPAs reported greater use of and satisfaction with their advisors for curriculum and registration assistance than students with lower GPAs. Furthermore, for several advising needs, students with higher GPAs who had assigned faculty advisors used or were more satisfied with their assigned advisors than similar students assigned professional advisors. Younger students used their advisors more frequently than older students for career guidance and personal counseling. This was especially true for younger students assigned to faculty advisors.
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Leach, Rebecca B., and Tiffany R. Wang. "Academic Advisee Motives for Pursuing Out-of-Class Communication with the Faculty Academic Advisor." Communication Education 64, no. 3 (2015): 325–43. http://dx.doi.org/10.1080/03634523.2015.1038726.
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Lasrida Lumban Batu, Lisbet N. Sihombing, and Eva Pasaribu. "Pengaruh Model Pembelajaran Problem Based Learning terhadap Hasil Belajar Siswa pada Tema 1 Subtema 1 di Kelas III SD Negeri Percontohan 091317 Pematang Raya." Multiverse: Open Multidisciplinary Journal 1, no. 1 (2022): 30–32. http://dx.doi.org/10.57251/multiverse.v1i1.622.
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The Effect of Problem Based Learning Learning Model on Student Learning Outcomes in Class III SD Negeri Pilot 091317 Pematang Raya. manuscript. UHKBPNP University Primary School Teacher Education and Education Studies Program. Advisor I Lisbet Novianti Sihombing, S.Pd., M.Pd and Advisor II Eva Pasaribu, S.Pd., M.Pd. This research will be conducted to find out whether the results of the Problem Based Learning Learning Model are consistent with student learning outcomes. This type of refining is a quasi-experimental which involves two lobes treated with pekkaduan berda. The population in this study were third grade students of SD Negeri Pilot 091317 Pematang Raya and two classes were selected by cluster random sampling as the research sample, namely classes IIIA and IIIB. Class IIIA is the experimental class that uses the Problem Based Learning Expenditure Model, while class IIIB is the control class that uses conventional belebajang. The research instrument used for learning ability. The data that has been built using the instrument was analyzed using technical descriptive statistics and inferential.
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Vikulov, S. F., and E. V. Gorgola. "International financial institutions are a leaf on modern neoliberalism. The review of the book by Tat'yana A. Yugai, The Hell Machine Coercing to Freedom." National Interests: Priorities and Security 16, no. 4 (2020): 792–98. http://dx.doi.org/10.24891/ni.16.4.792.
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KOSBA, ESSAM M., VANIA G. DIMITROVA, and ROGER D. BOYLE. "USING FUZZY TECHNIQUES TO MODEL STUDENTS IN WEB-BASED LEARNING ENVIRONMENTS." International Journal on Artificial Intelligence Tools 13, no. 02 (2004): 279–97. http://dx.doi.org/10.1142/s0218213004001557.
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The paper illustrates how fuzzy techniques can be applied to address problems experienced in widespread computing systems for distance learning. Many educational organizations use Web Course Management Systems (WCMS) to run distance courses. In such environments, facilitators often face difficulties in monitoring and understanding problems experienced by distance learners. An approach is proposed here where artificial advisors are built to offer distance-learning facilitators informed advice of what the problems/needs of individuals and groups may be, as well as to suggest appropriate actions when possible. We have developed the TADV (Teacher ADVisor) framework, which builds student, group, and class models based on the tracking information generated by WCMS, and uses these models to generate advice to the course instructors. This paper introduces TADV and describes the fuzzy approach used for extracting individual, group and class models. TADV is currently exemplified in a Discrete Mathematics course run at the Arab Academy for Science and Technology and Maritime Transport, Alexandria, Egypt.
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SARAKAEVA, ASIA A. "Strategies and Strategists in Chinese Historical TV Series." Art and Science of Television 18, no. 3 (2022): 147–76. http://dx.doi.org/10.30628/1994-9529-2022-18.3-147-176.
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In his article, I examine the image of a political strategist, popular in Chinese historical cinema, the origin of which can be traced to historical chronicles and fiction. Analysis of their cinematographic representation allows to single out the characteristic features of this image, distinguishing it from the functionally close, yet not identical image of a noble minister. Further, I suggest that the literary and cinematic image of Zhuge Liang, the famous politician and strategist of the Three Kingdoms, serves as an archetype of a political and military advisor in general, and substantiate this hypothesis. Based on the analysis of sovereign-advisor relations, I make an assumption that the very image of an advisor, with their characteristic appearance, personality, and their relationship with their overlord, takes its origins in the self-presentation of shi— a social class of the Warring States period. The leading values in this class were intelligence, loyalty to the lord, and freedom. I suggest and support a hypothesis that there is a genetic connection between the image of an advisor and the teaching of Legalism. Counterbalancing and complement to this image in a costume series is the role of a noble minister, which has its ideological basis in the Confucian philosophy. Apart from that, I name some of the strategies of seizing and retaining power, as well as domestic and foreign policy strategies, frequently seen in TV shows. The analysis of political and administrative methods in many Chinese historical series indicates that foreign policy, as presented in these shows, allows for more manipulations, but also more variability. The internal political opposition, by contrast, is almost completely delegitimized, its goals are a priori recognized as immoral and self-serving, and, consequently, the only way left for the sovereign and their advisor is to directly suppress their internal opponents. The results of this study lead to a number of conclusions about the political culture of China as manifested in this type of TV products, and about the strategemic thinking underlying this culture.
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Agnes Chintya Dewi, Lisbet N. Sihombing, and Hetdy Sitio. "Pengaruh Motivasi Belajar terhadap Prestasi Belajar IPS Siswa Kelas VI di UPTD SD Negeri 122348 Pematangsiantar." Tematik: Jurnal Penelitian Pendidikan Dasar 1, no. 2 (2022): 79–83. http://dx.doi.org/10.57251/tem.v1i2.610.
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The Influence of Motivation on Social Studies Learning Achievement of Class VI Students at UPTD SD Negeri 122348 Pematangsiantar. Thesis. UHKBPNP University Primary School Teacher Education and Education Studies Program. Advisor I Lisbet Novianti Sihombing,S.Pd.,M.Pd and Advisor II Hetdy Sitio M.Pd. This study aims to determine whether there are. The Influence of Motivation on Social Studies Learning Achievement of Grade VI Students at UPTD SD Negeri 122348 Pematangsiantar. This study aims to determine the description of the social studies learning motivation of grade VI students and how much influence the social studies learning motivation of students at UPTD SD Negeri 122348. This study is a quantitative method, with the entire research population. class VI students totaling 33 people. The results showed that the description of the social studies learning motivation of students at UPTD SD Negeri 122348 Pematangsiantar was in the high category, namely 87% of the social studies learning achievement of students and the influence of social studies learning motivation.
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Dr., I. Narsis. "Modeling the Gender Gap in Career Satisfaction Among Insurance Advisor's of Life Insurance Corporation India." International Journal of Management and Humanities (IJMH) 9, no. 11 (2023): 12–20. https://doi.org/10.35940/ijmh.K1637.0791123.
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<strong>Abstract: </strong>The global economy saw a sharp decrease as a result of the COVID-19 coronavirus's proliferation. Numerous businesses, particularly those that deliver in-person services, had to temporarily close due to the exceptional measures taken to contain the outbreak, such as lockdowns. The feeling and impression of one's own professional achievement in proportion to one's personal self-set criteria is known as career satisfaction. A career in the Indian Insurance sector can not only be quite challenging but also rewarding. The Covid-19 heavily affected the regular income of both salaried and non-salaried class people. In this circumstance, the insurance agents faced certain difficulties such as, collecting premium from policy holders, getting new policy and settling the policy claim on time. Overall, the aforementioned challenges undoubtedly had an impact on the insurance advisor's ability to accomplish his or her career goals, including those for income, progress, and the acquisition of new skills. In context with the above topic, this short-term research paper attempts to reveal the career satisfaction between Male and Female Insurance agents of LIC during this pandemic period. There's no significant difference among male and female insurance advisors with regard to of their professional accomplishments, professional goals, and advancement in their careers, according to the findings. Nevertheless, female insurance advisers are happier than male insurance advisors with the strides they have made in achieving their financial and skill-development objectives.
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De Maio, Carmela, and Anibeth Desierto. "First year Business students’ perceptions of academic support through embedding. A Practice Report." Student Success 7, no. 1 (2016): 57–63. http://dx.doi.org/10.5204/ssj.v7i1.324.
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This paper explores the perceptions of first year Business students to embedding sessions and additional support workshops offered through a collaboration between learning advisors and lecturers in a first year foundational unit. Through a social constructivist lens and utilising action research methods, questionnaires (n=42) were administered to two cohorts of students at the conclusion of the unit in 2011 and 2012 to explore firstly, whether or not they perceived the embedding sessions to be of benefit and, secondly, whether having the learning advisor in the class made them more likely to utilise additional support outside class time. In addition, the researchers sought to explore whether there were any improvements in students’ final results which might be attributable to the academic support offered to them through the embedding sessions. The findings from the quantitative and qualitative data suggest that the students perceived the embedding workshops as having positive effects on their academic literacy skills. Furthermore, there was a slight increase in the number of students that sought additional support outside of class time. However, it appears that the embedding workshops did not lead to an improvement in students’ final marks for the unit and this is an area which requires further investigation.
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Sciutto, Mark J. "The Methods and Statistics Portfolio: A Resource for the Introductory Course and Beyond." Teaching of Psychology 29, no. 3 (2002): 213–15. http://dx.doi.org/10.1207/s15328023top2903_07.
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In this article, I describe how I used a portfolio assignment to facilitate learning and provide a useful resource for future research experiences. Forty-eight students from 2 introductory methods and statistics courses compiled a portfolio that reflected their individual approach to understanding the major topics of the class. The portfolio assignment required students to integrate material from the text, class lectures, and laboratory assignments into a resource that was both personally relevant and accessible. Student feedback, performance data, and thesis advisor ratings supported the utility of this assignment.
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Shostrand, Lisa, Erin Kramer, and Brett Hartman. "95 Clinical Advisor-Led Dressing Class to Enhance New Graduate Nurse Pediatric Burn Knowledge and Perceived Relevance." Journal of Burn Care & Research 46, Supplement_1 (2025): S77. https://doi.org/10.1093/jbcr/iraf019.095.
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Abstract Introduction New graduate nurses receive limited pediatric burn background information and/or direct practice with ointments, dressings, and other burn products prior to unit shifts as part of standard orientation. To enhance opportunities for clinical growth, a burn dressing class was developed and taught by a core group of pediatric burn nurse advisors to new graduate nurses. This experiential learning session entailed a pre- and post-questionnaire in addition to a class evaluation to assess knowledge and relevance. Methods A six-hour class created and led by two burn clinical advisors was taught to five new burn nurses. A six-question multiple choice test was administered to the participating nurses immediately pre- and post- instruction. A dressing skills validation was also completed after an instructor-led hand and head wrapping demonstration. Teach back was the method utilized to ensure learning had occurred. At the conclusion of the class, an evaluation assessing relevance and understanding was distributed. Results Results demonstrated the nurses increased their knowledge from the pre- to post-assessment by 40%. The nurses completed the head and hand wrapping skills validations with 100% accuracy. Four of the five participants completed the post-class evaluation. All felt the class was relevant to current practice, while 50% stated they could now be successful and had a solid understanding of the concepts taught. All participants shared they were either completely riveted or their attention rarely wandered during the presentation. Conclusions For this new pediatric burn nurse group, results illustrated learning occurred and practice relevance was appreciated immediately after the class concluded. This score improvement demonstrated a knowledge and application gap in burn care in the new graduate burn nurse orientation which was addressed by this course. Assessment from a competency lens or organizational perspective would be the next step for higher level evaluation. Applicability of Research to Practice Pediatric burn nursing is a specialty field with which many new graduate nurses have no background knowledge or experience. By creating a pediatric-specific burn course, new nurses can have the chance to learn, apply and demonstrate burn wrapping skills prior to completing orientation. This instruction may be impactful on future research of orientation best practices as well as learning needs of new pediatric burn nurses. Funding for the Study N/A
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Klooster, Jacqueline. "Solon of Athens as a Precedent for Plutarch’s Authorial Persona." Mnemosyne 71, no. 2 (2018): 247–64. http://dx.doi.org/10.1163/1568525x-12342247.
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AbstractSolon is the subject of both a Plutarchan biography (Solon) and a philosophical dialogue (Convivium septem sapientium). In this article I argue that Plutarch creates a precedent for his authorial persona of wise but modest adviser of the ruling class under the Roman empire in the figure of the Athenian sage Solon, presumably inspired by the fact that Herodotus used Solon as a text-internal alter ego. To this end I analyze in particular how Plutarch represents Solon’s way of dealing with rulers and tyrants (Pisistratus, Philocyprus, Croesus, Periander). I ask whether in this Solon can be considered successful or not, and why. I submit that Plutarch’s representation of Solon aims to provide authority to some of the remarkable aspects of his authorial persona, in particular its emphatic modesty and pragmatism with regard to absolute rule. Plutarch does this in particular by showing that it was a time-honoured and respectable practice for wise Greeks to act as advisor to rulers, even tyrants.
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Teria Sofiandira, Vegi, Desy Anindia, and Sripit Widiasttuti. "DEVELOPMENT OF ALPHABET BLOCK MEDIA FOR BEGINNING READING LEARNING IN CLASS I ELEMENTARY SCHOOL." JOSAR (Journal of Students Academic Research) 8, no. 2 (2023): 436–50. http://dx.doi.org/10.35457/josar.v8i2.3146.
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Study Program Teaching Faculty of Education Science Balitar Islamic University Advisor (I) Desy Anindia, M.Pd.I. Advisor (II) Sripit Widiastuti, S.Pd,. M.Pd.This research has a background in the low ability to recognize students' letters with low interest in reading as well, so additional learning media is needed besides books and worksheets that are commonly used in schools. The purpose of this study was to show the feasibility of the media and to find out the readability of teachers and students towards alphabet block media in the ability to recognize letters, so as to be able to develop early reading skills in grade 1 elementary school children.Data collection techniques by conducting questionnaire observations and interviews using the Research and development (R & D) method approach with 7 research steps. Data collection was carried out on 60 grade 1 elementary school students in 3 schools, namely SDN Sidorejo 01, SDN Doko 01 and SDN Doko 02 along with their class teachers.The results of the feasibility analysis of the media through 3 validators obtained a percentage with an average value of 94.29%, material and language experts obtained a percentage with an average value of 95.00%. From the results of the media feasibility analysis by 3 media expert validators, 3 material and language expert validators on product development which were then tested by conducting field practice to analyze the readability of teachers and students towards the media as teaching materials for beginning reading learning materials. In the teacher readability test, the results obtained were 93.94% & student readability was 90.44% with a very decent category. The results of the validation and readability stated that the alphabet block learning media was included in the very feasible criteria with an achievement level of 81% - 100%.
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GARCIA, VERONICA, WILHEMINA AGBEMAKPLIDO, HANAN ABDELA, OSCAR LOPEZ JR., and RASHIDA REGISTE. "High School Students' Perspectives on the 2001 No Child Left Behind Act's Definition of a Highly Qualified Teacher." Harvard Educational Review 76, no. 4 (2006): 698–724. http://dx.doi.org/10.17763/haer.76.4.nu70771132536q86.
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In this article, four urban high school students and their student leadership and social justice class advisor address the question, "What are high school students' perspectives on the 2001 No Child Left Behind Act's (NCLB) definition of a highly qualified teacher?" As the advisor to the course, Garcia challenged her students to examine their high school experiences with teachers. The students offer personal stories that describe what they consider the critical qualities of teachers — qualities not based solely on the credentials and education status defined by NCLB. The authors suggest that highly qualified teachers should cultivate safe, respectful, culturally sensitive, and responsive learning communities, establish relationships with students' families and communities, express their high expectations for their students through instructional planning and implementation, and know how students learn. This article urges educators and policymakers to consider the students' voices and school experiences when making decisions about their educational needs, including the critical issue of teacher quality.
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Boyarskaya, Yu V. "INTERACTION BETWEEN THE EDUCATIONAL ADVISOR TO THE PRINCIPAL AND CLASS TEACHERS: KEY ASPECTS AND PRACTICAL RECOMMENDATIONS." Современные наукоемкие технологии (Modern High Technologies), no. 4 2025 (2025): 103–7. https://doi.org/10.17513/snt.40372.
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Nurjannah, Nurjannah, Nasrah Nasrah, and Nurul Magfirah. "Pengaruh Metode Eksperimen Terhadap Hasil Belajar Ilmu Pengetahuan Alam Siswa Kelas V SD Inpres Maroanging Gowa." Journal on Education 6, no. 1 (2023): 1285–90. http://dx.doi.org/10.31004/joe.v6i1.3081.
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The Effect of Experimental Methods on Science Learning Outcomes of Grade V Students at SD Inpres Maroanging Gowa. Thesis. Elementary School Teacher Education Study Program, Faculty of Teacher Training and Education, University of Muhammadiyah Makassar. Advisor I Nasrah and advisor II Nurul Magfirah. The purpose of this study was to determine the effect of the Experimental Method on Science Learning Outcomes of Class V SD Inpres Maroanging Gowa. This research is a type of pre-experimental research with a research design using one group pretest-posttest design through a quantitative approach. This design made two measurements, the first (pretest) and the second measurement (posttest). The sample in this study was class V SD Inpres Maroanging Gowa, as many as 28 students. The results showed that the average student pretest result was 51.07 in the low category, then the experimental method was applied to the learning process so that the posttest results of students achieved an average score of 76.25 in the medium category. The N-Gain analysis shows that the average normalized gain is 0.54 in the medium category. Based on the hypothesis test using the paired samples test, the value of Sig. (2-tailed) of 0.000 <0.05. This means that H0 is rejected and H1 is accepted, which means that there is an effect of the use of the experimental method on science learning outcomes in fifth grade students at SD Inpres Maroanging Gowa on heat transfer material.
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Ekenberg, Christina, Man-Hung Eric Tang, Daniel D. Murray, et al. "1284. Study of Single Nucleotide Polymorphisms Associated with HIV-1 Set-Point Viral Load in Antiretroviral Therapy-Naïve HIV-Positive Participants of the START Study." Open Forum Infectious Diseases 5, suppl_1 (2018): S392. http://dx.doi.org/10.1093/ofid/ofy210.1117.
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Abstract Background HIV-1 set-point viral load (SPVL) is predictive of disease progression and shows variability across HIV-1-positive (HIV+) persons. Various factors may influence SPVL including viral features, environmental exposure and host genetics. To identify single nucleotide polymorphisms (SNPs) associated with SPVL, we performed a genome-wide association study (GWAS) on a subset of participants from the Strategic Timing of AntiRetroviral Treatment (START) study covering a demographically diverse population. Methods. Consenting participants were antiretroviral therapy (ART)-naïve and SPVL was taken as log10(HIV RNA) at study entry. Genotypic data were generated on a custom content Affymetrix Axiom SNP array covering 770,558 probes. The Ensembl Gene database, assembly GRCh37.p13, was used for annotation. Principal component analysis (PCA) was used to identify population structures, and analysis of variance (ANOVA) was performed to detect associations between SNPs and SPVL. SNPs with zero variance or minor allele frequency (MAF) ≤0.05 were removed. Results. Among the 2,544 participants, PCA showed distinct population structures with strong separation between black (n = 578) and nonblack (n = 1,966) participants, Figure 1. ANOVA was performed independently on both subsets. Two SNPs located in the Major Histocompatibility Complex (MHC) class I region of chromosome six reached genome-wide significance (P &lt; 5 × 10–8) in the non-black population: rs4418214 (P = 1.74 × 10-10), and rs57989216 (P = 3.96 × 10–8), Figure 2. Two additional SNPs, rs9264942 (P = 5.99 × 10–8) and rs7356880 (P = 9.69 × 10–8), in the same region approached significance. The minor alleles of all four SNPs were associated with lower SPVL, Figure 3. While no SNPs reached genome-wide significance in the black group, we observed similar trends toward lower SPVL for both rs4418214 and rs57989216. Conclusion. In this study we confirm the association of a previously reported SNP (rs4418214) and identify a novel candidate SNP (rs57989216) associated with lower SPVL in a population of nonblack, ART-naïve HIV+ persons. Current findings suggest that the effects of these SNPs are consistent across race groups, but further studies are required to confirm this. Our results support previous findings that variation in the MHC class I region is a major host determinant of HIV-1 control. Disclosures D. D. Murray, Centre of Excellence for Health, Immunity and Infectious diseases (CHIP), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark: Employee, Salary. J. M. Molina, Gilead: Scientific Advisor, Consulting fee. Merck: Scientific Advisor, Consulting fee. ViiV: Scientific Advisor, Consulting fee. Teva: Scientific Advisor, Consulting fee.
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Adri, Adriana, and Acep Haryudin. "THE USE OF CIRC TO IMPROVE STUDENT’S READING ABILITY." PROJECT (Professional Journal of English Education) 2, no. 3 (2019): 345. http://dx.doi.org/10.22460/project.v2i3.p345-351.
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The purpose of research was to find whether the learning model of the CIRC based on student learning was effective in improving reading ability in English learner. This activity aims to get experience in learning process and education activities that is used as a provision to become a candidate for educator. Researcher need to be able to have values, attitudes, knowledge and the skills needed as an english teacher. Research activities starts from observation to implementation in learning process in class and activity carried out after doing consultation with the teacher supervisor first and also guidance with the Lecturer Field Advisor. In teaching process the writer found in class that students need to improve their reading ability. That's why the writer use the titte in this journal is The Use Of Circ To Improve Student's Reading Ability. CIRC is Cooperative Integrated Reading and Composition. Implementation of this research was carried out in the class XI Manajemen Pemasaran SMK YPKKP Bandung.
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Eskreis-Winkler, Lauren, Katherine L. Milkman, Dena M. Gromet, and Angela L. Duckworth. "A large-scale field experiment shows giving advice improves academic outcomes for the advisor." Proceedings of the National Academy of Sciences 116, no. 30 (2019): 14808–10. http://dx.doi.org/10.1073/pnas.1908779116.
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Common sense suggests that people struggling to achieve their goals benefit from receiving motivational advice. What if the reverse is true? In a preregistered field experiment, we tested whether giving motivational advice raises academic achievement for the advisor. We randomly assigned n = 1,982 high school students to a treatment condition, in which they gave motivational advice (e.g., how to stop procrastinating) to younger students, or to a control condition. Advice givers earned higher report card grades in both math and a self-selected target class over an academic quarter. This psychologically wise advice-giving nudge, which has relevance for policy and practice, suggests a valuable approach to improving achievement: one that puts people in a position to give.
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Csipke, Emese, Lauren Yates, Esme Moniz Cook, et al. "Promoting independence in dementia: protocol for a feasibility trial of the PRIDE intervention for living well with dementia." International Journal of Clinical Trials 5, no. 4 (2018): 177. http://dx.doi.org/10.18203/2349-3259.ijct20184399.
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<p class="abstract"><strong>Background:</strong> Dementia can lead to social exclusion, loss of identity and independence, due to deterioration in cognition and activities of daily living. The aim of the study is to investigate the feasibility of the Promoting Independence in Dementia (PRIDE) intervention, designed to facilitate independence in people with mild dementia.</p><p class="abstract"><strong>Methods:</strong> This is a mixed-methods feasibility trial of the PRIDE, in preparation for a future randomised controlled trial. Up to 50 people with dementia will be recruited. Demetia advisors will deliver the three session intervention. Quantitative outcomes will be taken at baseline and up to three months post baseline. Fidelity checklists will assess fidelity to the intervention. Qualitative implementation data will be gathered in a series of post-intervention semi-structured interviews with staff and participants. This will include data to examine participant experiences of and engagement with the intervention, and other aspects of delivery such as recruitment of DAWs, fidelity and experiences of receiving and delivering the intervention. This study aims to establish and field test the PRIDE intervention; determine the recruitment rate of sites, providers and participants; assess fidelity in delivery of the intervention and engagement with people with dementia; assess the feasibility and acceptability of outcome measure data and assess the acceptability of the intervention by stakeholders.</p><p class="abstract"><strong>Conclusions: </strong>There has been increased need for non-pharmacological interventions for mild dementia. The results of this feasibility study will allow us to plan for a definitive RCT of a three session dementia advisor led intervention for mild dementia.</p>
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Al Saleh, Aminah Nurfajri, Andi Husniati, and Abdul Gaffar. "ANALISIS KESULITAN MENYELESAIKAN SOAL MATEMATIKA MATERI POLA BILANGAN DI TINJAU DARI PERBEDAAN GENDER SISWA KELAS VIII SMP NEGERI 34 MAKASSAR." SIGMA: JURNAL PENDIDIKAN MATEMATIKA 13, no. 1 (2021): 19–25. http://dx.doi.org/10.26618/sigma.v13i1.4832.
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Aminah Nurfajri Al Saleh. 2020. Difficulty Analysis of Solving Mathematical Problems with Number Patterns in terms of Gender Differences in Class VIII Students of SMP Negeri 34 Makassar. Essay. Mathematics Education Study Program, Teacher Training and Education Faculty, Muhammadiyah University of Makassar. Advisor I Andi Husniati and Advisor II Abdul Gaffar. This study aims to describe the location of the difficulties experienced by students in solving math problems on number pattern material for class VIII SMP Negeri 34 Makassar in the 2020/2021 school year in terms of gender differences. This research is a research that uses a qualitative descriptive approach which is designed to determine the location of the students' difficulties in solving math problems with the number pattern material in terms of gender differences. The data analyzed were data on the location of student difficulties in terms of gender differences. Data collection methods used were giving essay tests and interviews. The questions used in the test measure the location of the student's difficulty, amounting to 2 questions which contain indicators of the difficulty of concepts, principles, and verbal. These questions were done by 2 students in 45 minutes and the interview aimed to find out where the students' difficulties in answering the questions were. The results of the study provide information that there are differences in the difficulties of male and female students in solving math problems with the number pattern material. This is in line with the results of this study as it has been described that the difficulties of grade VIII students of SMP Negeri 34 Makassar include principle difficulties for male students while female students include principle and verbal difficulties.
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Oganesyan, Sergey S. "Birth Anniversary of Oganesyan Sergey S., Doctor of Education, Professor, Class 1 State Advisor of the Russian Federation." legal education and science, no. 2 (March 30, 2017): 3–4. http://dx.doi.org/10.18572/2072-4438-2017-2-3-4.
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Pangaribuan, Henny Herliny, Nurul Hasanah Nasution, Rosari Hasianna Sagala, Try Yeni Veronica Zega, and Yunita Purba. "Teacher Class Management Ability in the Teaching and Learning Process in Grade V SD Negeri 153069 Pinangsori 2." Formosa Journal of Science and Technology 2, no. 6 (2023): 1527–36. http://dx.doi.org/10.55927/fjst.v2i6.4482.
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This study aims to evaluate the teacher's role in classroom management and observing student behavior at SD Negeri 153069 Pinangsori 2. The case study approach is used by collecting data through observation and interviews. The results of the study show that teachers have succeeded in implementing classroom management well, understanding student characteristics, providing guidance, and organizing learning activities. The teacher also acts as a motivator and advisor for students. Student behavior shows good quality, with enthusiasm in learning and acceptance of the teacher. Assessment is carried out through pretest and posttest to measure student understanding. This research suggests that teachers continue to improve skills in classroom management and provide appropriate feedback to students. In conclusion, teachers have an important role in creating an effective and efficient learning environment and developing positive student behavior.
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Mutmainah, Ismul, Ahmadi Ahmadi, Cecep Zakarias El Bilad, and Aulia Mustika Ilmiani. "Improved Ability to Compose Arabic Sentences Using the Hot Potatoes Application." Journal Of Foreign Language Learning and Teaching 2, no. 1 (2022): 1–13. http://dx.doi.org/10.23971/jfllt.v2i1.5416.
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Ismul Mutmainah, 2021, The Effectiveness of Using Hot Potatoes Applications in Improving the Ability to Arrange Arabic Sentences in Mts. Istiqamah Muara Teweh. Department of Language Education, Faculty of Tarbiyah and Teacher Training, at IAIN Palangka Raya, Advisor (1) Dr. Ahmadi, M.Pd. Supervisor (2) Cecep Zakarias El Bilad, M.Pd.This study aims to determine the effectiveness of the use of the Hot Potatoes application in improving students' ability to compose Arabic sentences. This study uses a quantitative research method of experimental type or a true experimental design using a pretest-posttest control group design. The sample in the study was class VII students at Madrasah Tsanawiyah Istiqamah Muara Teweh. From this study, the following results were found: 1. Students in the control class and Students from the experimental class show an increase in their ability to compose sentences seen from the average value of the pretest and posttest results. So, it can be concluded that the Hot Potatoes application can improve students' ability to compose sentences. 2. The comparison of the posttest mean scores of the experimental class and the control class using the independent sample test, obtained a significance value of 0.020 which is smaller than 0.05, so there is a significant difference in learning outcomes between experimental class students who learn to use the Hot Potatoes application with control class students who do not use the Hot Potatoes application. The Hot Potatoes application was more effective for students in this study.
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Yoon, Sung-Jun, and Jun-Hyung Baek. "Effect of After-School Sports Club Instruction Type on Elementary School Students' Class Satisfaction." Korean Society for Holistic Convergence Education 26, no. 4 (2022): 321–38. http://dx.doi.org/10.35184/kshce.2022.26.4.321.
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This study was conducted to investigate the effect on class satisfaction of elementary school students according to the instructional type of after-school sports club activities. The subjects of this study were 306 male students and 218 female students who are currently participating in after-school sports club activities for students in grades 3-6 of an elementary school located in S city, for a total of 524 students. As the data processing method, SPSS/ PC (win 21.0) program was used. Independent t-test and one-way analysis of variance were used to compare the teacher's instructional style and class satisfaction. Multivariate analysis was used to compare and analyze the class satisfaction of students according to the instructional type. Multiple regression analysis was used to examine the relationship between instructional type and students' class satisfaction. As for the guidance type of the advisor, the dictatorial behavior type was the highest, and there was a significant difference in the student's gender and the supervisor's gender in the class satisfaction. In addition, statistically significant differences were found in positive reward type, professor and instruction type, and social support behavior type in the influence on the teacher's class satisfaction. Therefore, it is thought that tutors will be able to increase class satisfaction by operating classes with closeness to students and actively using positive feedback, and by conducting classes that respect the opinions of individual students.
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Mack, Andrew R., Christopher Bethel, Steven Marshall, et al. "133. ARGONAUT-III: Susceptibility of Carbapenem-resistant Klebsiellae to Cefepime-Taniborbactam." Open Forum Infectious Diseases 8, Supplement_1 (2021): S81—S82. http://dx.doi.org/10.1093/ofid/ofab466.133.
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Abstract Background Klebsiellae are Gram-negative pathogens responsible for serious nosocomial and community-acquired infections. Carbapenem resistance, both intrinsic and acquired, complicates therapy. Taniborbactam (formerly VNRX-5133; Fig 1) is a bicyclic boronate β-lactamase inhibitor (BLI) that inhibits all four Ambler classes of β-lactamase enzymes, both serine- and metallo-, with the notable exception of class B IMP β-lactamases. Taniborbactam is currently undergoing phase 3 clinical trials in combination with cefepime (FEP; Fig 1) as part of the β-lactam-BLI (BL-BLI) combination FEP-taniborbactam (FTB). Figure 1. Structures of taniborbactam and cefepime. The β-lactamase inhibitor is in red and the β-lactam antibiotic is in black. Methods We determined the activity of FTB against 200 carbapenem-resistant Klebsiellae (CRK) strains collected as part of the Antibiotic Resistance Leadership Group (ARLG) Consortium on Resistance against Carbapenems in Klebsiella (CRACKLE) study. Among these strains, 193 expressed class A KPCs, one expressed a class B NDM, and six expressed class D OXA-48 or variants. Broth microdilution minimum inhibitory concentrations (MIC)s were determined using the ThermoFisher Sensititre system with custom assay panels. American Type Culture Collection strains were used for quality control. The susceptible-dose-dependent breakpoint for FEP was provisionally used for FTB, where taniborbactam was fixed at 4 µg/mL. Results Among the 200 Klebsiella strains tested, susceptibility for β-lactams alone ranged from 1% for ceftazidime (CAZ), 2.5% for meropenem, and 13.5% for FEP (Table 1). The addition of BLIs increased % susceptibility compared to BL alone to: 98% for CAZ-avibactam (CZA); 95.5% for MEM-vaborbactam (MVB); and 99.0% for FTB. MIC50 and MIC90 were in the susceptible and provisionally susceptible range for CZA and MVB, and in the provisionally susceptible range for FTB. Analyzing the CZA and MVB non-susceptible strains, 7 of 9 MVB non-susceptible strains and 2 of 4 CZA-resistant strains were provisionally susceptible to FTB. Table 1. MIC50 and MIC90 values (μg/mL) and percent susceptibility for Klebsiella pneumoniae strains (n=200). AMK, amikacin; CST, colistin; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; FTB, cefepime-taniborbactam; MEM, meropenem; MVB, meropenem-vaborbactam; TGC, tigecycline. * The breakpoint for CST is intermediate, as no susceptible breakpoint is available. ** The susceptible-dose-dependent breakpoint for FEP alone was provisionally applied to FTB, where taniborbactam was fixed at 4 μg/mL. Breakpoints from CLSI M100, 31st ed, 2021. Conclusion The addition of taniborbactam restored susceptibility to FEP in 99.0% of CRACKLE isolates studied, comparable to CZA and MVB. Taniborbactam also restored FEP activity against some MVB- and CZA-resistant strains. FTB may provide a promising therapy for CRK infections. Disclosures Robin Patel, MD, 1928 Diagnostics (Consultant)BioFire Diagnostics (Grant/Research Support)ContraFect Corporation (Grant/Research Support)Curetis (Consultant)Hylomorph AG (Grant/Research Support)IDSA (Other Financial or Material Support, Editor’s Stipend)Infectious Diseases Board Review Course (Other Financial or Material Support, Honoraria)Mammoth Biosciences (Consultant)NBME (Other Financial or Material Support, Honoraria)Netflix (Consultant)Next Gen Diagnostics (Consultant)PathoQuest (Consultant)PhAST (Consultant)Qvella (Consultant)Samsung (Other Financial or Material Support, Patent Royalties)Selux Diagnostics (Consultant)Shionogi & Co., Ltd. (Grant/Research Support)Specific Technologies (Consultant)TenNor Therapeutics Limited (Grant/Research Support)Torus Biosystems (Consultant)Up-to-Date (Other Financial or Material Support, Honoraria) Robin Patel, MD, BioFire (Individual(s) Involved: Self): Grant/Research Support; Contrafect (Individual(s) Involved: Self): Grant/Research Support; IDSA (Individual(s) Involved: Self): Editor’s stipend; NBME, Up-to-Date and the Infectious Diseases Board Review Course (Individual(s) Involved: Self): Honoraria; Netflix (Individual(s) Involved: Self): Consultant; TenNor Therapeutics Limited (Individual(s) Involved: Self): Grant/Research Support; to Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, Torus Biosystems, Mammoth Biosciences and Qvella (Individual(s) Involved: Self): Consultant David van Duin, MD, PhD, Entasis (Advisor or Review Panel member)genentech (Advisor or Review Panel member)Karius (Advisor or Review Panel member)Merck (Grant/Research Support, Advisor or Review Panel member)Pfizer (Consultant, Advisor or Review Panel member)Qpex (Advisor or Review Panel member)Shionogi (Grant/Research Support, Scientific Research Study Investigator, Advisor or Review Panel member)Utility (Advisor or Review Panel member) Vance G. Fowler, Jr., MD, MHS, Achaogen (Consultant)Advanced Liquid Logics (Grant/Research Support)Affinergy (Consultant, Grant/Research Support)Affinium (Consultant)Akagera (Consultant)Allergan (Grant/Research Support)Amphliphi Biosciences (Consultant)Aridis (Consultant)Armata (Consultant)Basilea (Consultant, Grant/Research Support)Bayer (Consultant)C3J (Consultant)Cerexa (Consultant, Other Financial or Material Support, Educational fees)Contrafect (Consultant, Grant/Research Support)Debiopharm (Consultant, Other Financial or Material Support, Educational fees)Destiny (Consultant)Durata (Consultant, Other Financial or Material Support, educational fees)Genentech (Consultant, Grant/Research Support)Green Cross (Other Financial or Material Support, Educational fees)Integrated Biotherapeutics (Consultant)Janssen (Consultant, Grant/Research Support)Karius (Grant/Research Support)Locus (Grant/Research Support)Medical Biosurfaces (Grant/Research Support)Medicines Co. (Consultant)MedImmune (Consultant, Grant/Research Support)Merck (Grant/Research Support)NIH (Grant/Research Support)Novadigm (Consultant)Novartis (Consultant, Grant/Research Support)Pfizer (Grant/Research Support)Regeneron (Consultant, Grant/Research Support)sepsis diagnostics (Other Financial or Material Support, Pending patent for host gene expression signature diagnostic for sepsis.)Tetraphase (Consultant)Theravance (Consultant, Grant/Research Support, Other Financial or Material Support, Educational fees)Trius (Consultant)UpToDate (Other Financial or Material Support, Royalties)Valanbio (Consultant, Other Financial or Material Support, Stock options)xBiotech (Consultant) Daniel D. Rhoads, MD, Becton, Dickinson and Company (Grant/Research Support) Michael Jacobs, MBBS, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) Focco van den Akker, PhD, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) David A. Six, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Greg Moeck, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Krisztina M. Papp-Wallace, Ph.D., Merck & Co., Inc. (Grant/Research Support)Spero Therapeutics, Inc. (Grant/Research Support)Venatorx Pharmaceuticals, Inc. (Grant/Research Support)Wockhardt Ltd. (Other Financial or Material Support, Research Collaborator) Robert A. Bonomo, MD, entasis (Research Grant or Support)Merck (Grant/Research Support)NIH (Grant/Research Support)VA Merit Award (Grant/Research Support)VenatoRx (Grant/Research Support)
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Costa, Luciano J., Parameswaran Hari, Shaji K. Kumar, et al. "Overall Survival of Triple Class Refractory, Penta-Exposed Multiple Myeloma (MM) Patients Treated with Selinexor Plus Dexamethasone or Conventional Care: A Combined Analysis of the STORM and Mammoth Studies." Blood 134, Supplement_1 (2019): 3125. http://dx.doi.org/10.1182/blood-2019-124991.
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Introduction: Proteasome inhibitors (PI), immunomodulatory agents (IMiDs) and the CD38 monoclonal antibody daratumumab (dara) have transformed the management of MM, yet eventual refractoriness to these agents seems inevitable. Relapsed and refractory MM (RRMM) which becomes triple class refractory (TCR, i.e. refractory to a PI, an IMiD and Dara) uncommonly responds to further lines of therapy and survival is dismal. Selinexor is a selective inhibitor of nuclear export compound targeting exportin 1 (XPO1) which is overexpressed in MM cells and essential for their survival. In the STORM study, selinexor in combination with low-dose dexamethasone (Sd) demonstrated promising efficacy in TCR, penta-exposed (TCR-PE, i.e. exposed to lenalidomide, pomalidomide, bortezomib, carfilzomib and dara) MM. Establishing the natural history for outcomes in the TCR-PE population can help provide context to understand the outcomes observed with Sd in STORM. In the retrospective MAMMOTH study, we reported the outcomes of patients with RRMM after they became refractory to dara, including a subset of patients who were TCR. We further analyzed the MAMMOTH dataset to generate a cohort of patients similar to patients in STORM in order to compare conventional care vs. Sd. Methods: We included all patients in STORM who received Sd as the first line therapy after they achieved TCR-PE status (n=64). We extracted from the MAMMOTH dataset all patients who were not exposed to Sd in a subsequent line of therapy, became TCR-PE and who received subsequent MM-directed therapy (n=128). Overall response rate (ORR) was evaluated according to IMWG criteria. Overall survival (OS) was calculated from the time of initiation of next line of therapy after TCR-PE status until death or last follow-up. We compared OS in STORM vs. MAMMOTH utilizing cox-regression analysis with adjustment for covariables potentially influencing the outcome. Results: Baseline patient characteristics and prior therapies are per table. The two cohorts were similar in terms of age, number of prior lines of therapy and presence of high-risk cytogenetic abnormalities. STORM patients had longer time between MM diagnosis and post TCR-PE therapy with a higher proportion of refractoriness to carfilzomib. Patients in STORM had ORR to Sd of 32.8% vs 25.0% for patients receiving conventional care in MAMMOTH (P=0.078). In direct comparison, patients in STORM had better OS than patients in MAMMOTH (median 10.4 vs. 6.9 months) (P=0.043, figure). In multivariate analysis, STORM patients had lower risk of death in comparison with MAMMOTH patients (aHR=0.55, 95%C.I. 0.35-0.86, P=0.009). Refractoriness to carfilzomib (aHR=2.20, 95%C.I. 1.16-4.15, P=0.015) and high-risk cytogenetics (aHR-1.66, 95% C.I. 1.13-2.42, P=0.009) were also associated with inferior OS. Conclusion: Despite inherent limitations in comparison of trial enrollees vs. real world patients, this analysis suggests improved OS with Sd vs conventional care in patients with TCR-PE RRMM. Prognosis for these patients remains poor and underscores the need for therapeutic advancements. Disclosures Costa: Janssen: Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Research Funding; Sanofi: Consultancy, Honoraria, Speakers Bureau; GSK: Consultancy, Honoraria, Research Funding; Abbvie: Consultancy; Karyopharm: Consultancy; Fujimoto Pharmaceutical Corporation Japan: Other: Advisor; Amgen: Consultancy, Honoraria, Research Funding, Speakers Bureau. Hari:Kite: Consultancy, Honoraria; Amgen: Research Funding; Spectrum: Consultancy, Research Funding; Sanofi: Honoraria, Research Funding; Janssen: Consultancy, Honoraria; BMS: Consultancy, Research Funding; Celgene: Consultancy, Honoraria, Research Funding; Takeda: Consultancy, Honoraria, Research Funding; Cell Vault: Equity Ownership; AbbVie: Consultancy, Honoraria. Kumar:Janssen: Consultancy, Research Funding; Takeda: Research Funding; Celgene: Consultancy, Research Funding. Tang:Karyopharm: Employment. Shah:Karyopharm Therapeutics Inc: Employment, Equity Ownership. Jagannath:BMS: Consultancy; Merck: Consultancy; Medicom: Speakers Bureau; Celgene: Consultancy; Novartis: Consultancy; Multiple Myeloma Research Foundation: Speakers Bureau. Chari:Oncoceutics: Research Funding; Novartis Pharmaceuticals: Research Funding; GlaxoSmithKline: Research Funding; Array Biopharma: Research Funding; Karyopharm: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Millennium/Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Consultancy; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Sanofi: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pharmacyclics: Research Funding. Shacham:Karyopharm Therapeutics Inc: Employment, Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties. Ma:Karyopharm: Employment, Equity Ownership. Siegel:Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Janssen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Bristol-Myers Squibb Company: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau. Biran:Amgen: Consultancy, Honoraria, Research Funding; Merck: Research Funding; Janssen: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Bristol Meyers Squibb: Research Funding. Lonial:BMS: Consultancy; Genentech: Consultancy; GSK: Consultancy; Janssen: Consultancy, Research Funding; Takeda: Consultancy, Research Funding; Amgen: Consultancy; Celgene Corporation: Consultancy, Research Funding; Karyopharm: Consultancy. Richardson:Amgen: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Oncopeptides: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Research Funding. Kauffman:Karyopharm Therapeutics Inc: Employment, Equity Ownership, Membership on an entity's Board of Directors or advisory committees. Malek:Adaptive: Consultancy; Amgen: Speakers Bureau; Janssen: Speakers Bureau; Celgene: Consultancy; Takeda: Consultancy; Sanofi: Consultancy; Medpacto: Research Funding. Fiala:Incyte: Research Funding. Usmani:Amgen, Celgene, Janssen, Sanofi, Takeda: Speakers Bureau; Amgen, Bristol-Myers Squibb, Celgene, Janssen, Merck, SkylineDX, Takeda: Other: Consultant/Advisor; Amgen Array Biopharma, Bristol-Myers Squibb, Celgene, Janssen, Merck, Pharmacyclics, Sanofi, Takeda: Other: Research Grant. Kang:Takeda Oncology: Consultancy; InCyte Corportation: Research Funding. Cornell:Takeda: Consultancy; KaryoPharm: Consultancy.
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Bishop, P. L., T. Yu, M. J. Kupferle, D. Moll, C. Alonso, and M. Koechling. "Teaching future professors how to teach." Water Science and Technology 43, no. 5 (2001): 327–32. http://dx.doi.org/10.2166/wst.2001.0318.
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This paper describes a course designed to provide hands-on teaching experience to future professors and to incorporate techniques for more effective teaching. A team of Ph.D. candidates, under the direction of a senior faculty member, prepared a new course from beginning to end and then offered it to a class of graduate students. The course was developed using the unit map concept so that the presentations by the five student-instructors complemented and built upon one another. Immediately after each class, feedback was given to the student-instructors by the faculty advisor and the other student-instructors. Review of video tapes of the lecture reinforced this feedback. At the completion of the course, both students and student-instructors were surveyed as to the effectiveness of the course and the student-instructors. This teaching experience and the feedback obtained from the surveys will be invaluable to the student-instructors in their future development.
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Roselle, Peter. "The Evolution of Integrating ESG Analysis into Wealth Management Decisions." Journal of Applied Corporate Finance 28, no. 2 (2016): 75–79. http://dx.doi.org/10.1111/jacf.12178.
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Retail investors rely heavily on the advice of their financial advisors. But relatively few of those advisors have begun to incorporate investment strategies based on environmental, social and governance (ESG) factors for their client's portfolios. The author attributes this lack of interest to the disappointing returns of the “first generation” of ESG retail investment products, which approached the topic through a “socially responsible investing” (SRI) lens with mandates to exclude companies and industries viewed as having negative impact on society. These early “negative screening” directives had the effect of reducing the size of the manager's investable universe, which effectively ensured that SRI portfolio would underperform the overall market.The author, who is himself a practicing financial advisor, proposes that an innovative evolutionary process is underway in which investment managers are shifting away from a penchant for “negative screening” to a more inclusive approach he refers to as “best‐in‐class ESG Factor Integration.” And he identifies three main catalysts for this evolution: (1) greater disclosure of ESG data by public companies; (2) the growing accuracy and accessibility of ESG research, from commercial as well as academic sources; and (3) the inclusion of ESG factors with the traditional value drivers emphasized by the fundamental and quantitative methods used by portfolio managers.Although such integration is yet in its early stages, the author is optimistic that this growing trend will become an important part of an overall sustainable investing movement. No longer confined to large institutional investors, ESG factor integration is now available through a growing number of products and investment platforms.
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Nurmila Auliya, Sitti Aida Azis, and Syahruddin Syahruddin. "Hubungan Keterampilan Membaca dengan Hasil Belajar Bahasa Indonesia Siswa Kelas IV UPTD SPF SD Negeri 64 Medde Kabupaten Soppeng." Jurnal Motivasi Pendidikan dan Bahasa 1, no. 2 (2023): 12–21. https://doi.org/10.59581/jmpb-widyakarya.v1i2.254.
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Nurmila Auliya. 2023. The Relationship between Reading Skills and Indonesian Language Learning Outcomes for Class IV UPTD SPF SD Negeri 64 Medde, Soppeng Regency. Thesis. Elementary School Teacher Education Study Program, Faculty of Teacher Training and Education, University of Muhammadiyah Makassar. Supervisor I Sitti Aida Aziz and Advisor II Syahruddin.This study aims to determine the relationship between reading skills and learning outcomes for Indonesian language students in class IV UPTD SPF SD Negeri 64 Medde, Soppeng Regency. This type of research is a quantitative correlation research. The population of this study were all students of class IV UPTD SPF at SD Negeri 64 Medde, Soppeng Regency. The sample of this research is 19 people. Data analysis techniques were carried out using descriptive analysis techniques and correlation analysis between the independent variables and the dependent variable by utilizing SPSS version 23.The results of this study indicate that the correlation coefficient between reading skills and Indonesian learning outcomes is rxy = 0.947, this correlation is included in the very strong category and sig. shows the number 0.000 which shows that there is a significant difference between reading skills and Indonesian learning outcomes because p < 0.05 (0.000 < 0.05). Thus it can be concluded that there is a significant relationship between reading skills and the results of learning Indonesian for class IV UPTD SPF SD Negeri 64 Medde, Soppeng Regency.
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Cespedes, Michelle, Jill Blumenthal, Karam Mounzer, et al. "848. Approaches to Optimize Recruitment of Historically Underrepresented Black and Hispanic/LatinX MSM, Transgender, and Gender Non-binary Individuals into the Lenacapavir for PrEP (PURPOSE 2) Trial." Open Forum Infectious Diseases 8, Supplement_1 (2021): S514. http://dx.doi.org/10.1093/ofid/ofab466.1043.
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Abstract Background Black and Hispanic/Latinx gay and other men who have sex with men (MSM), transgender women (TGW), transgender men (TGM), and gender nonbinary individuals (GNB) have been historically underrepresented in HIV prevention trials despite being disproportionately affected by the disease. Therefore, studies of pre-exposure prophylaxis (PrEP), a highly effective intervention for reducing HIV incidence, should include these individuals, and doing so would promote generalizability of the findings. Methods PURPOSE 2 (GS-US-528-9023) will evaluate a twice-yearly long-acting subcutaneous, first in class capsid inhibitor, lenacapavir, for PrEP in MSM, TGW, TGM, and GNB in the US, Brazil, Peru, and South Africa. The study team adopted a multifactorial approach to address historic underrepresentation. This included a literature review to assess successful evidence-based approaches for increasing enrollment of Black and Hispanic/ LatinX MSM, TG, and GNB individuals. We engaged with community and patient advocates as well as key stakeholders to solicit feedback prior to protocol development. Results We established a trial-specific Global Community Advisory Group and implemented their recommendations for site selection, investigator and staff diversity, and strong linkage with community-based organizations. We recruited new community-based research sites and principal investigators (PIs) to mirror historically underrepresented populations and emphasized mentorship of junior sub-Is by seasoned PIs to support enrollment and retention. We developed required trainings for all study and site staff on good participatory practices for PrEP, anti-racism and transgender cultural humility. We established recruitment goals of 50% Black and 20% Hispanic/LatinX MSM in the US, and 20% TGW study-wide. Our strategy to ensure achievement of these overall goals involves nuanced site-specific recruitment goals considering site capacity, local demographics, and HIV incidence data. We will review metrics weekly during enrollment and make any necessary adjustments. Conclusion Using novel approaches, we have carefully chosen with whom, where, and how we will collaborate to increase the diversity, equity, and inclusion in the PURPOSE 2 trial. Disclosures Michelle Cespedes, MD, MS, Gilead Sciences Inc. (Scientific Research Study Investigator, Advisor or Review Panel member, Research Grant or Support)GlaxoSmithKline (Scientific Research Study Investigator, Research Grant or Support) Jill Blumenthal, MD, Gilead Sciences (Grant/Research Support, Scientific Research Study Investigator) Karam Mounzer, MD, Epividian (Advisor or Review Panel member)Gilead Sciences Inc. (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Janssen (Consultant, Research Grant or Support, Speaker’s Bureau)Merck (Research Grant or Support, Speaker’s Bureau)ViiV Healthcare (Consultant, Speaker’s Bureau) Moti Ramgopal, MD FACP FIDSA, Abbvie (Scientific Research Study Investigator, Speaker’s Bureau)Gilead (Consultant, Scientific Research Study Investigator, Speaker’s Bureau)Janssen (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Merck (Consultant, Scientific Research Study Investigator)ViiV (Consultant, Scientific Research Study Investigator, Speaker’s Bureau) Ayana Elliott, DNP, APRN, FNP-C, NEA-BC, Gilead Sciences Inc. (Employee, Shareholder) A.C. Demidont, MD, Gilead Sciences Inc. (Employee, Shareholder) C. Chauncey Watson, MD, Gilead Sciences Inc. (Employee, Shareholder) Christoph C. Carter, MD, Gilead Sciences Inc. (Employee, Shareholder) Alex Kintu, MD, ScD, Gilead Sciences Inc. (Employee, Shareholder) Moupali Das, MD, Gilead Sciences Inc. (Employee, Shareholder) Jared Baeten, MD, PHD, Gilead Sciences Inc. (Employee, Shareholder) Onyema Ogbuagu, MD, Gilead Sciences Inc. (Scientific Research Study Investigator, Advisor or Review Panel member, Research Grant or Support, Other Financial or Material Support)ViiV Healthcare (Advisor or Review Panel member)
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Muchlish, Imam Jauhar, Faras Indriani, Novmiasti Sela Mardefi, and Tri Hernadi. "Role of teacher in handling the bullying behavior in students of elementary school." International Journal on Education Insight 4, no. 1 (2023): 15–24. http://dx.doi.org/10.12928/ijei.v4i1.10294.
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This research aims to describe the role of teachers in dealing with bullying behavior in students in grades I to VI at SD Negeri Balirejo, one of public elementary schools in Yogyakarta, Indonesia. This research uses a qualitative approach. Subjects in this research include teachers and students at school. The data collected in this research are processed through data reduction, data presentation, and conclusion. Based on the research results, the role of class teachers in dealing with bullying, namely (1) as a mediator and facilitator, by cultivating positive relationships, encouraging good social behavior, and seeking learning resources; (2) as a guide by providing explanations and actions when bullying occurs; (3) as an advisor by providing advice; and (4) giving sanctions, put up posters of positive habits.
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Niya, Wa Ode Nur, Yani Taufik, Salahuddin Salahuddin, and Nurhayu Malik. "MODAL SOSIAL DALAM KEGIATAN PENYULUHAN PERTANIAN DI KOTA KENDARI." Jurnal Ilmiah Penyuluhan dan Pengembangan Masyarakat 3, no. 2 (2023): 59. http://dx.doi.org/10.56189/jippm.v3i2.35302.
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The purpose of this investigation is to (1) determine the identity of agricultural advisor in Kendari City; and (2) knowing the social capital of extension workers in carrying out extension activities in the Kendari City. The samples in the study were all agricultural extension workers in Kendari City. The data analysis used in this study Is a descriptive quantitative analysis that is processed using the class interval formula. The results of this study showed that the social capital of Kendari City is generally in the good category. This can also be seen from the aspects of trust, reciprocity and social interaction are in the good category. This means that agricultural extension workers in Kendari City have implemented the elements of social capital well.
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Fajriyah, Fajriyah, Mufiqur Rahman, Mo'tasim Mo'tasim, et al. "Kiai dan Pendidikan Toleransi di Pesantren." Jurnal Intelektual: Jurnal Pendidikan dan Studi Keislaman 11, no. 2 (2021): 158–72. http://dx.doi.org/10.33367/ji.v11i2.1670.
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The kiai as a designer, implementer and controller of the course of education in the pesantren. Kiai determines the direction of a boarding school education. The attitude and character of the kiai determine the color of the pesantren education. This study is to describe particularly a role of Kiai in pesantren management patterns by promoting tolerance education as one of the Kiai's leadership styles in the pesantren. This research method uses qualitative methods with case studies. The data network was carried out by observation, interviews, documentation, and Focus Group Discussion (FGD). While data analysis using data reduction, display and conclusion. As well this study found a new model of tolerance education which a model of kiai cantered or a Model of kiai. First kiai became advisor and planner to set a education of tolerance based on multicultural view. Second, learning of tolerance delivered in the class integrated with the all the subjects, teachers should stated about tolerance during the class. And then the practice of tolerance accommodated by kiai including the community and santri activities as well kiai welcomed the tradition of community.
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Kaye, Shaina, Joshua Pathman, and Joseph A. Skelton. "Development and Implementation of a Student-Led Lifestyle Medicine Curriculum." American Journal of Lifestyle Medicine 13, no. 3 (2018): 253–61. http://dx.doi.org/10.1177/1559827618821322.
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Significant contributors to rising health care costs are diseases influenced by lifestyle, such as cardiovascular disease, diabetes, and cancer. Unfortunately, American medical education devotes disproportionately little time training future doctors in prevention. Approach. With the support of medical education leadership, medical students collaborated with a faculty advisor at Wake Forest School of Medicine to test the feasibility of a broad-based, student-led lifestyle medicine curriculum. After 3 introductory sessions delivered to an entire medical school class, a smaller pilot series with 16 first-year medical students was held after-hours, featuring experiential learning in nutrition and cooking, physical activity, and sleep. The 8 modules were designed to improve student health, wellness, and knowledge of health behaviors. Feedback. The program was implemented into the first-year medical school class. An unforeseen benefit of the pilot was increased student volunteering in community-based wellness activities and research. Two components of success were the hands-on, experiential modules and being student-led. Details on curriculum development, schedule, and content are provided.
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Mack, Andrew R., Christopher Bethel, Steven Marshall, et al. "1055. ARGONAUT-IV: Susceptibility of Carbapenem-resistant Klebsiellae to Ceftibuten/VNRX-5236." Open Forum Infectious Diseases 8, Supplement_1 (2021): S619—S620. http://dx.doi.org/10.1093/ofid/ofab466.1249.
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Abstract Background Carbapenem resistance in Klebsiellae spp. arises through mutational and acquired mechanisms and is considered an “urgent threat” by the CDC. VNRX-5236 is a bicyclic boronate β-lactamase inhibitor (BLI) that combines oral bioavailability (via etzadroxil prodrug VNRX-7145; Figure 1) and activity against all three Ambler classes of serine β-lactamases. VNRX-7145 is currently in development with the oral cephalosporin, ceftibuten (CTB) (Figure 1). Figure 1. Structures of VNRX-7145, VNRX-5236, and ceftibuten. The β-lactamase inhibitors are in red and the β-lactam antibiotic is in black. Methods The activity of CTB/VNRX-5236 against 200 carbapenem-resistant Klebsiellae from the Consortium on Resistance against Carbapenems in Klebsiella (CRACKLE) was assessed in this study. Among these, 193 expressed class A KPC enzymes, one expressed a class B NDM enzyme, and six expressed a class D OXA-48 or variant enzyme. Minimum inhibitory concentrations (MIC) were determined by broth microdilution (CLSI M07 Ed. 11) using the ThermoFisher Sensititre system with custom assay panels. MICs were interpreted using CLSI M100 Ed. 30, except the EUCAST breakpoint for CTB (S≤1 µg/mL) was used for CTB and was applied for comparative purposes to CTB/VNRX-5236 MICs where VNRX-5236 was fixed at 4 µg/mL. American Type Culture Collection strains were used for quality control. Results 92.5% of stains studied in this CRACKLE collection were provisionally susceptible to CTB/VNRX-5236. In comparison, strains were 95.5% and 98% susceptible to meropenem-vaborbactam (MVB) and ceftazidime-avibactam (CZA), respectively. MIC50s were in the susceptible range for CZA, MVB, and CTB/VNRX-5236; and resistant for CTB, ceftazidime (CAZ) and meropenem (MEM). MIC90s were in the susceptible range for CZA, MVB, and CTB/VNRX-5236 and resistant range for CAZ, MEM, and CTB (Table 1). One of four CZA-resistant and three of nine MVB non-susceptible strains were provisionally susceptible to CTB/VNRX-5236. MIC50 and MIC90 values (µg/mL) and percent susceptibility for Klebsiella pneumoniae strains (n=200). AMK, amikacin; CST, colistin; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; MEM, meropenem; MVB, meropenem-vaborbactam; CTB, ceftibuten; TGC, tigecycline. * The breakpoint for CST is intermediate, as no susceptible breakpoint is available. ** The CTB breakpoint is valid only for urinary tract isolates. *** The breakpoint for CTB was provisionally used for CTB/VNRX-5236, where VNRX-5236 was fixed at 4 µg/mL. Conclusion The addition of VNRX-5236 enhanced the activity of CTB against the 200 Klebsiella isolates tested, reaching a total of 92.5% susceptibility. The prodrug (VNRX-7145) allows for oral administration, making it a potential option for step-down therapy. Importantly, VNRX-5236 has a broader spectrum of activity than existing oral BLIs, opening new treatment options for resistant infections as a key addition to the existing antibiotic arsenal. Disclosures Robin Patel, MD, 1928 Diagnostics (Consultant)BioFire Diagnostics (Grant/Research Support)ContraFect Corporation (Grant/Research Support)Curetis (Consultant)Hylomorph AG (Grant/Research Support)IDSA (Other Financial or Material Support, Editor’s Stipend)Infectious Diseases Board Review Course (Other Financial or Material Support, Honoraria)Mammoth Biosciences (Consultant)NBME (Other Financial or Material Support, Honoraria)Netflix (Consultant)Next Gen Diagnostics (Consultant)PathoQuest (Consultant)PhAST (Consultant)Qvella (Consultant)Samsung (Other Financial or Material Support, Patent Royalties)Selux Diagnostics (Consultant)Shionogi & Co., Ltd. (Grant/Research Support)Specific Technologies (Consultant)TenNor Therapeutics Limited (Grant/Research Support)Torus Biosystems (Consultant)Up-to-Date (Other Financial or Material Support, Honoraria) Robin Patel, MD, BioFire (Individual(s) Involved: Self): Grant/Research Support; Contrafect (Individual(s) Involved: Self): Grant/Research Support; IDSA (Individual(s) Involved: Self): Editor’s stipend; NBME, Up-to-Date and the Infectious Diseases Board Review Course (Individual(s) Involved: Self): Honoraria; Netflix (Individual(s) Involved: Self): Consultant; TenNor Therapeutics Limited (Individual(s) Involved: Self): Grant/Research Support; to Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, Torus Biosystems, Mammoth Biosciences and Qvella (Individual(s) Involved: Self): Consultant David van Duin, MD, PhD, Entasis (Advisor or Review Panel member)genentech (Advisor or Review Panel member)Karius (Advisor or Review Panel member)Merck (Grant/Research Support, Advisor or Review Panel member)Pfizer (Consultant, Advisor or Review Panel member)Qpex (Advisor or Review Panel member)Shionogi (Grant/Research Support, Scientific Research Study Investigator, Advisor or Review Panel member)Utility (Advisor or Review Panel member) Vance G. Fowler, Jr., MD, MHS, Achaogen (Consultant)Advanced Liquid Logics (Grant/Research Support)Affinergy (Consultant, Grant/Research Support)Affinium (Consultant)Akagera (Consultant)Allergan (Grant/Research Support)Amphliphi Biosciences (Consultant)Aridis (Consultant)Armata (Consultant)Basilea (Consultant, Grant/Research Support)Bayer (Consultant)C3J (Consultant)Cerexa (Consultant, Other Financial or Material Support, Educational fees)Contrafect (Consultant, Grant/Research Support)Debiopharm (Consultant, Other Financial or Material Support, Educational fees)Destiny (Consultant)Durata (Consultant, Other Financial or Material Support, educational fees)Genentech (Consultant, Grant/Research Support)Green Cross (Other Financial or Material Support, Educational fees)Integrated Biotherapeutics (Consultant)Janssen (Consultant, Grant/Research Support)Karius (Grant/Research Support)Locus (Grant/Research Support)Medical Biosurfaces (Grant/Research Support)Medicines Co. (Consultant)MedImmune (Consultant, Grant/Research Support)Merck (Grant/Research Support)NIH (Grant/Research Support)Novadigm (Consultant)Novartis (Consultant, Grant/Research Support)Pfizer (Grant/Research Support)Regeneron (Consultant, Grant/Research Support)sepsis diagnostics (Other Financial or Material Support, Pending patent for host gene expression signature diagnostic for sepsis.)Tetraphase (Consultant)Theravance (Consultant, Grant/Research Support, Other Financial or Material Support, Educational fees)Trius (Consultant)UpToDate (Other Financial or Material Support, Royalties)Valanbio (Consultant, Other Financial or Material Support, Stock options)xBiotech (Consultant) Daniel D. Rhoads, MD, Becton, Dickinson and Company (Grant/Research Support) Michael Jacobs, MBBS, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) Focco van den Akker, PhD, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) David A. Six, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Greg Moeck, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Krisztina M. Papp-Wallace, Ph.D., Merck & Co., Inc. (Grant/Research Support)Spero Therapeutics, Inc. (Grant/Research Support)Venatorx Pharmaceuticals, Inc. (Grant/Research Support)Wockhardt Ltd. (Other Financial or Material Support, Research Collaborator) Robert A. Bonomo, MD, entasis (Research Grant or Support)Merck (Grant/Research Support)NIH (Grant/Research Support)VA Merit Award (Grant/Research Support)VenatoRx (Grant/Research Support)
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Mack, Andrew R., Christopher Bethel, Steven Marshall, et al. "1063. ARGONAUT-V: Susceptibility of Multidrug-Resistant (MDR) Pseudomonas aeruginosa to Cefepime-Taniborbactam." Open Forum Infectious Diseases 8, Supplement_1 (2021): S623—S624. http://dx.doi.org/10.1093/ofid/ofab466.1257.
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Abstract Background P. aeruginosa is a Gram-negative pathogen responsible for many serious infections. MDR, both intrinsic and acquired, presents major clinical challenges. Taniborbactam (formerly VNRX-5133; Fig 1) is a β-lactamase inhibitor (BLI) characterized as a bicyclic boronate, uniquely possessing activity toward all four Ambler classes of β-lactamases, both serine and metallo, with the exception of class B IMP β-lactamases. The β-lactam-BLI (BL-BLI) combination cefepime-taniborbactam (FTB; Fig 1) is currently in phase 3 clinical trials. Structures of taniborbactam and cefepime. The β-lactamase inhibitor is in red and the β-lactam antibiotic is in black. Methods The activity of FTB was tested against 197 well-characterized clinical P. aeruginosa isolates that were part of PRIMERS (Platforms for Rapid Identification of MDR-Gram-negative bacteria and Evaluation of Resistance Studies). Nearly 58% of these strains were reported as carbapenem-non-susceptible. Porin changes, efflux pumps, and/or the presence of acquired class A or class B carbapenemases were previously reported. Broth microdilution minimum inhibitory concentrations (MICs) were determined by CLSI M07 Ed. 11 methods with custom Sensititre frozen panels and interpreted using CLSI M100 Ed. 30 breakpoints. American Type Culture Collection strains were used for quality control. FEP breakpoints were provisionally used for FTB, where taniborbactam was fixed at 4 µg/mL. Results Percent susceptibility to BL agents alone was 45.2% for imipenem (IPM), 55.8% for meropenem (MEM), 60.9% for ceftazidime (CAZ), and 67.0% for FEP. The addition of BLI to BL increased % susceptibility for MEM-vaborbactam (MVB), 56.9%; ceftolozane-tazobactam (C/T), 77.7%, CAZ-avibactam (CZA), 79.7%, and FTB, 82.7%. MIC50s were in the susceptible range for all drugs except IPM, which was intermediate, and all MIC90s were in the resistant range (Table 1). Taniborbactam reduced FEP MIC by 2-fold in 32% of isolates and ≥ 4-fold in 13% of isolates. Against carbapenem-non-susceptible strains, % susceptibilities were: FTB, 68.5%, CZA, 63.0%, C/T, 59.3%; and MVB, 21.3% (Table 2). MIC50 and MIC90 values (µg/mL) and percent susceptibility (%S) for all P. aeruginosa strains (n=197). AMK, amikacin; ATM, aztreonam; C/T, ceftolozane-tazobactam; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; FTB, cefepime-taniborbactam; IPM, imipenem; MEM, meropenem; MVB, meropenem-vaborbactam; TZP, piperacillin-tazobactam; TOB, tobramycin. *The breakpoints for FEP and MEM alone were provisionally applied to FTB and MVB, respectively. Tazobactam, avibactam, and taniborbactam were fixed at 4 µg/mL, while vaborbactam was fixed at 8 µg/mL. Breakpoints from CLSI M100, 31st ed, 2021. MIC50 and MIC90 values (µg/mL) and percent susceptibility (%S) for the subset of carbapenem-non-susceptible P. aeruginosa strains (n=108). AMK, amikacin; ATM, aztreonam; C/T, ceftolozane-tazobactam; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; FTB, cefepime-taniborbactam; IPM, imipenem; MEM, meropenem; MVB, meropenem-vaborbactam; TZP, piperacillin-tazobactam; TOB, tobramycin. *The breakpoints for FEP and MEM alone were provisionally applied to FTB and MVB, respectively. Tazobactam, avibactam, and taniborbactam were fixed at 4 µg/mL, while vaborbactam was fixed at 8 µg/mL. Breakpoints from CLSI M100, 31st ed, 2021. Conclusion Compared to MVB, CZA, and C/T, FTB demonstrated the greatest activity against the 197 P. aeruginosa strains tested, including many carbapenem-non-susceptible strains. Pending completion of clinical development, FTB may be a promising therapeutic option for MDR P. aeruginosa infections. Disclosures Robin Patel, MD, 1928 Diagnostics (Consultant)BioFire Diagnostics (Grant/Research Support)ContraFect Corporation (Grant/Research Support)Curetis (Consultant)Hylomorph AG (Grant/Research Support)IDSA (Other Financial or Material Support, Editor’s Stipend)Infectious Diseases Board Review Course (Other Financial or Material Support, Honoraria)Mammoth Biosciences (Consultant)NBME (Other Financial or Material Support, Honoraria)Netflix (Consultant)Next Gen Diagnostics (Consultant)PathoQuest (Consultant)PhAST (Consultant)Qvella (Consultant)Samsung (Other Financial or Material Support, Patent Royalties)Selux Diagnostics (Consultant)Shionogi & Co., Ltd. (Grant/Research Support)Specific Technologies (Consultant)TenNor Therapeutics Limited (Grant/Research Support)Torus Biosystems (Consultant)Up-to-Date (Other Financial or Material Support, Honoraria) Robin Patel, MD, BioFire (Individual(s) Involved: Self): Grant/Research Support; Contrafect (Individual(s) Involved: Self): Grant/Research Support; IDSA (Individual(s) Involved: Self): Editor’s stipend; NBME, Up-to-Date and the Infectious Diseases Board Review Course (Individual(s) Involved: Self): Honoraria; Netflix (Individual(s) Involved: Self): Consultant; TenNor Therapeutics Limited (Individual(s) Involved: Self): Grant/Research Support; to Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, Torus Biosystems, Mammoth Biosciences and Qvella (Individual(s) Involved: Self): Consultant David van Duin, MD, PhD, Entasis (Advisor or Review Panel member)genentech (Advisor or Review Panel member)Karius (Advisor or Review Panel member)Merck (Grant/Research Support, Advisor or Review Panel member)Pfizer (Consultant, Advisor or Review Panel member)Qpex (Advisor or Review Panel member)Shionogi (Grant/Research Support, Scientific Research Study Investigator, Advisor or Review Panel member)Utility (Advisor or Review Panel member) Vance G. Fowler, Jr., MD, MHS, Achaogen (Consultant)Advanced Liquid Logics (Grant/Research Support)Affinergy (Consultant, Grant/Research Support)Affinium (Consultant)Akagera (Consultant)Allergan (Grant/Research Support)Amphliphi Biosciences (Consultant)Aridis (Consultant)Armata (Consultant)Basilea (Consultant, Grant/Research Support)Bayer (Consultant)C3J (Consultant)Cerexa (Consultant, Other Financial or Material Support, Educational fees)Contrafect (Consultant, Grant/Research Support)Debiopharm (Consultant, Other Financial or Material Support, Educational fees)Destiny (Consultant)Durata (Consultant, Other Financial or Material Support, educational fees)Genentech (Consultant, Grant/Research Support)Green Cross (Other Financial or Material Support, Educational fees)Integrated Biotherapeutics (Consultant)Janssen (Consultant, Grant/Research Support)Karius (Grant/Research Support)Locus (Grant/Research Support)Medical Biosurfaces (Grant/Research Support)Medicines Co. (Consultant)MedImmune (Consultant, Grant/Research Support)Merck (Grant/Research Support)NIH (Grant/Research Support)Novadigm (Consultant)Novartis (Consultant, Grant/Research Support)Pfizer (Grant/Research Support)Regeneron (Consultant, Grant/Research Support)sepsis diagnostics (Other Financial or Material Support, Pending patent for host gene expression signature diagnostic for sepsis.)Tetraphase (Consultant)Theravance (Consultant, Grant/Research Support, Other Financial or Material Support, Educational fees)Trius (Consultant)UpToDate (Other Financial or Material Support, Royalties)Valanbio (Consultant, Other Financial or Material Support, Stock options)xBiotech (Consultant) Daniel D. Rhoads, MD, Becton, Dickinson and Company (Grant/Research Support) Michael Jacobs, MBBS, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) Focco van den Akker, PhD, Venatorx Pharmaceuticals, Inc. (Grant/Research Support) David A. Six, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Greg Moeck, PhD, Venatorx Pharmaceuticals, Inc. (Employee) Krisztina M. Papp-Wallace, Ph.D., Merck & Co., Inc. (Grant/Research Support)Spero Therapeutics, Inc. (Grant/Research Support)Venatorx Pharmaceuticals, Inc. (Grant/Research Support)Wockhardt Ltd. (Other Financial or Material Support, Research Collaborator) Robert A. Bonomo, MD, entasis (Research Grant or Support)Merck (Grant/Research Support)NIH (Grant/Research Support)VA Merit Award (Grant/Research Support)VenatoRx (Grant/Research Support)
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Shofi, Ahmad Thoyyib. "DEVELOPING ENGLISH CONVERSATION MATERIAL FOR ISLAMIC HIGH SCHOOL." Jurnal ELink 5, no. 1 (2018): 1. http://dx.doi.org/10.30736/e-link.v5i1.41.
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Students were very difficult to communicate with other people in English effectively. English was learned as a foreign language (EFL) in this country and Indonesian EFL students rarely speak English in their daily lives. English conversation class was taught by no particular book for both teacher and students. This failure was solved by developing an appropriate teaching material for English conversation class at the tenth grade of Islamic Senior High School, which covered conversational guide selection and the used of instructional media. It also aimed at activating the English conversation class. This study used the Research and Development (R&D) design. The data were collected through observation, interview, and questioners and analyzed using a guideline analysis, while the data of the students’ questioners were analyzed using tally system to find the percentage. The subjects of this study were the students of MA Al Karimi Gresik. There were 90 students of the tenth grade students. The material development started with writing material selected from the syllabus and follows CLT principles. The final product was the conversation material for Islamic Senior High Students. It also contained rubric assessment to record the students speaking progress both psychomotor aspect and affective aspect. The product contained Indonesian translation and no answers. Hopefully, the students could be active in responding the questions at the conversation classroom activity. The researcher wanted the English teacher understand the concept of CLT so that he could become the guide, trainer, advisor, and actor who can control the class.
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POPOVA, M. V. "THE RELATIONSHIP OF SUBJECTIVE CONTROL IN THE AREA OF ACHIEVEMENT AND FAILURE WITH PERSONALITY INDICATORS AS A SYSTEMIC CHARACTERISTIC OF THE REGULATORY SPHERE OF PERSONALITIES OF HIGH-CLASS ATHLETES." Научное мнение, no. 6 (August 19, 2024): 106–17. http://dx.doi.org/10.25807/22224378_2024_6_106.
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The article is devoted to the study of subjective qualities of high-class athletes as subjects of personality success in sports. The theoretical analysis of the role of subjective personality qualities in the regulative sphere of an athlete is carried out. The author performs a correlation analysis of the relationship between the Internality in the Field of Achievements scale of the Level of Subjective Control method by J. Rotter and the personality indicators of the 16-Factor Personality Questionnaire by R. B. Kettel, Ways of Coping Questionnaire by R. Lazarus and S. Folkman, Morphological Test of Life Values by V. F. Sopov and L. V. Karpushin, Moral Normativity by A. G. Maklakov and S. V. Chermyaninin, Moral and Ethical Responsibility of Personality by I. G. Tymoshchuk, Life Activity Standard by M. Y. Dvoretskaya, Friend-Advisor 2 by E. K. Veselova.
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Askim, Jostein, Rune Karlsen, and Kristoffer Kolltveit. "Public Office as a Stepping-Stone? Investigating the Careers of Ministerial Advisors." Political Studies Review, April 20, 2020, 147892992090699. http://dx.doi.org/10.1177/1478929920906991.
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Ministerial advisors have become an essential aspect of executive branches worldwide, thus making the ministerial advisor office a potential route for young politicians aspiring to an expanding political class. The article studies which professions ministerial advisors migrate to following their ministerial careers, how ministerial advisors’ post-ministerial careers compare to their pre-ministerial careers, and if the variance in careers can be explained by the resources that ministerial advisors obtain while in government. Empirically, the article draws on a cohort of 139 ministerial advisors in Norwegian governments between 2001 and 2009; it covers positions in the political sphere and the public, private and voluntary occupational sectors over a period from each ministerial advisor’s youth to the end of 2017. The bibliographic data are combined with surveys and elite interviews. The results show that more than expanding the political class as a recruitment ground for future Members of the Parliament and ministers, ministerial advisor appointments serve as stepping-stones to careers outside of politics. Most ministerial advisors experience shifts between occupational sectors and upwards to higher positions. However, ministerial advisors’ attractiveness in the labour market is surprisingly unaffected by what they actually did in office; rather, it rests on resources such as insider knowledge and networks.
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Prayoga, Dhanar. "Design and Evaluation of Robo-Advisors Using Index Fund and Alternative Assets of Cryptocurrency and Gold: Case of Indonesian Capital Market." International Journal of Current Science Research and Review 05, no. 02 (2022). http://dx.doi.org/10.47191/ijcsrr/v5-i2-12.
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Robo-advisor is one of the most prominent innovation in the wealth management industry, and its success in Indonesia has been evident in the case of Bibit. Therefore, wealth management companies need to employ Robo-Advisor to overcome their competition. This research aims to give recommendation on asset allocation method and asset class selection for Robo-Advisors in Indonesia using Sharpe Ratio Analysis. Then, the author will analyze the robo-advisor’s performance during equity market downturn. Finally, The Robo-Advisor’s actual performance will be tested in 2018, 2019, and 2020. The Sharpe ratio analysis result showed that Robo-Advisors seeking higher risk-adjusted return should choose mean-variance optimization over risk parity for asset allocation method, and the inclusion of gold and bitcoin in a portfolio of stock mutual fund and bond mutual fund increases the risk-adjusted return of the portfolio. The proposed robo-advisor’s portfolio protected investors from equity market downturn in 2011-2010 in 83,3% of the case. Finally, the proposed robo-advisor’s portfolio generated better return for the conservative, moderate and aggressive investor during 2018, 2019, and 2020 when compared to LQ45.
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Aleman, Soo, Heiner Wedemeyer, Maurizia Brunetto, et al. "P-2191. Efficacy and safety of buleviritide monotherapy for chronic hepatitis D in patients with and without cirrhosis: results from the week 144 interim analysis of a phase 3 randomized study." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.2345.
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Abstract Background Bulevirtide (BLV) is a first-in-class entry inhibitor for chronic hepatitis D (CHD) approved in Europe. Interim results from MYR301 (NCT03852719), a phase 3 randomized study, showed monotherapy with BLV 2 mg/d or 10 mg/d given subcutaneously was effective and safe over 144 weeks (W). With a greater risk of developing cirrhosis with HDV than HBV alone, we explore the impact of cirrhosis status on efficacy and safety of BLV monotherapy through 144W.Table 1.Efficacy results at Week 144 based on cirrhosis status Methods 150 patients with CHD were randomized and stratified based on the presence/absence of compensated cirrhosis (investigator-determined) as follows: Arm A: no anti-HDV treatment for 48W followed by BLV 10mg/d for 96W (n=51), Arm B: immediate treatment with BLV at 2 mg/d (n=49) or Arm C: immediate treatment with BLV at 10 mg/d (n=50) each for 144W. Combined response (CR) was defined as undetectable HDV RNA or decrease by ≥ 2 log10 IU/mL from baseline (virologic response (VR)) and ALT normalization. Other endpoints included VR, ALT normalization and undetectable HDV RNA. HDV RNA was quantified using RoboGene 2.0 (lower limit of quantification, 50 IU/mL; limit of detection, 6 IU/mL).Table 2:Safety results for BLV at Week 144 based on cirrhosis status Results A total of 71/150 (47%) participants had compensated cirrhosis; 73% and 27% were Child-Pugh score 5 and 6 respectively. Baseline (BL) characteristics were similar between those with and without cirrhosis with a few expected differences; higher liver stiffness measurement (LSM) and lower platelet count in those with cirrhosis. Differences in efficacy response rates by cirrhosis status were not consistently observed (Table 1). In a univariate logistic regression in W144 completers in Arm B and C, with BL HDV RNA &gt; 250 IU/mL, cirrhosis status was not a predictor of efficacy. Declines in both HDV RNA and ALT over time were consistent across subgroups regardless of cirrhosis status. There was no progression to liver-related outcomes over 144W except for 1 case of mild ascites in a patient with cirrhosis in Arm A. BLV was safe and well tolerated in both patients with and without cirrhosis (Table 2). Conclusion BLV monotherapy through Week 144 maintains efficacy and safety in patients regardless of cirrhosis status at baseline. Disclosures Soo Aleman, MD, PhD, AbbVie: Grant/Research Support|AbbVie: Honoraria|Biogen: Honoraria|Gilead Sciences, Inc.: Grant/Research Support|Gilead Sciences, Inc.: Honoraria|MSD: Honoraria Heiner Wedemeyer, MD, PhD, Abbott: Advisor/Consultant|Abbott: Honoraria|AbbVie: Advisor/Consultant|AbbVie: Honoraria|Arbutus: Advisor/Consultant|Boeringer Ingelheim: Advisor/Consultant|Boeringer Ingelheim: Honoraria|Bristol Myers Squibb: Advisor/Consultant|Bristol Myers Squibb: Honoraria|Dicerna: Advisor/Consultant|Gilead Sciences, Inc.: Advisor/Consultant|Gilead Sciences, Inc.: Honoraria|Johnson & Johnson/Janssen-Cilag: Advisor/Consultant|Johnson & Johnson/Janssen-Cilag: Honoraria|Merck/Schering-Plough: Advisor/Consultant|Merck/Schering-Plough: Honoraria|MYR GmbH: Advisor/Consultant|MYR GmbH: Honoraria|Novartis: Advisor/Consultant|Novartis: Honoraria|Roche: Advisor/Consultant|Roche: Honoraria|Siemens: Advisor/Consultant|Siemens: Honoraria|Transgene: Advisor/Consultant|Transgene: Honoraria|Viiv Healthcare: Advisor/Consultant|Viiv Healthcare: Honoraria|Vir Biotechnology: Advisor/Consultant Maurizia Brunetto, MD, AbbVie: Advisor/Consultant|AbbVie: speaker bureau|EISAI-MSD: Advisor/Consultant|EISAI-MSD: speaker bureau|Gilead Sciences, Inc.: Advisor/Consultant|Gilead Sciences, Inc.: speaker bureau|Janssen: Advisor/Consultant|Janssen: speaker bureau|Roche: Advisor/Consultant|Roche: speaker bureau Antje Blank, MD, Myr GMBH: Grant/Research Support Vladimir Chulanov, MD, PhD, AbbVie: Advisor/Consultant|AbbVie: Expert Testimony|AstraZeneca: Advisor/Consultant|AstraZeneca: Expert Testimony|Bristol Myers Squibb: Advisor/Consultant|Bristol Myers Squibb: Expert Testimony|Gilead Sciences, Inc.: Advisor/Consultant|Gilead Sciences, Inc.: Expert Testimony|GSK: Advisor/Consultant|GSK: Expert Testimony|Hepatera: Advisor/Consultant|Hepatera: Expert Testimony|Merck Sharp & Dohme: Advisor/Consultant|Merck Sharp & Dohme: Expert Testimony|Roche: Advisor/Consultant|Roche: Expert Testimony|R-Pharm: Advisor/Consultant|R-Pharm: Expert Testimony Grace Chee, PharmD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Private Company) Dmitry Manuilov, MD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Private Company) Mingyang Li, PhD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Private Company) Audrey Lau, MD, PhD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Private Company) Anu Osinusi, MD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Public Company) Steve Tseng, MD, Gilead Sciences, Inc.: Employee|Gilead Sciences, Inc.: Stocks/Bonds (Private Company) Julian Schulze Zur Wiesch, MD, PhD, Gilead Sciences, Inc.: Consultation and lecture fees Markus Cornberg, MD, PhD, AbbVie: Honoraria|Falk: Honoraria|Gilead Sciences, Inc.: Honoraria|GSK: Honoraria|Janssen-Cilag: Honoraria|Merck Sharp & Dohme: Honoraria|Novartis: Honoraria|Roche: Honoraria|Spring Bank Pharmaceuticals: Honoraria|Swedish Orphan Biovitrum: Honoraria Stefan Zeuzem, MD, PhD, AbbVie: Advisor/Consultant|AbbVie: speaker bureau|Allergan: Advisor/Consultant|Allergan: speaker bureau|BioMarin: Advisor/Consultant|BioMarin: speaker bureau|Gilead Sciences, Inc.: Advisor/Consultant|Gilead Sciences, Inc.: speaker bureau|Intercept: Advisor/Consultant|Intercept: speaker bureau|Janssen: Advisor/Consultant|Janssen: speaker bureau|Merck Sharp & Dohme: Advisor/Consultant|Merck Sharp & Dohme: speaker bureau|Novo Nordisk: Advisor/Consultant|Novo Nordisk: speaker bureau|Swedish Orphan Biovitrum: Advisor/Consultant|Swedish Orphan Biovitrum: speaker bureau|Theratechnologies: Advisor/Consultant|Theratechnologies: speaker bureau Pietro Lampertico, MD, AbbVie: speaking and teaching fees/ advisory committees and review panels|Aligos: speaking and teaching fees/ advisory committees and review panels|Alnylam: speaking and teaching fees/ advisory committees and review panels|Antios: speaking and teaching fees/ advisory committees and review panels|Arrowhead: speaking and teaching fees/ advisory committees and review panels|Bristol Myers Squibb: speaking and teaching fees/ advisory committees and review panels|Eiger Pharmaceuticals: speaking and teaching fees/ advisory committees and review panels|Gilead Sciences, Inc.: speaking and teaching fees/ advisory committees and review panels|GSK: speaking and teaching fees/ advisory committees and review panels|Janssen: speaking and teaching fees/ advisory committees and review panels|Merck Sharp & Dohme: speaking and teaching fees/ advisory committees and review panels|MYR GmbH: speaking and teaching fees/ advisory committees and review panels|Roche: speaking and teaching fees/ advisory committees and review panels|Spring Bank Pharmaceuticals: speaking and teaching fees/ advisory committees and review panels
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Bartek, Brian, Manoj Maddali, Rombout B. E. van Amstel, et al. "P-2237. Mortality and Causative Pathogens of Sepsis Differ by Molecular Phenotype in a Secondary Analysis of MARS." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.2390.
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Abstract Background Heterogeneity of host response has been a barrier to identifying novel therapies in sepsis. Two molecular phenotypes of critical illness, called the Hyperinflammatory and Hypoinflammatory, have been identified in multiple cohorts of sepsis and ARDS ( &gt;12,000 patients), with divergent biology, clinical course, and responses to therapy1. We evaluated whether these phenotypes were identifiable in MARS-- a large observational cohort of critically ill patients-- and whether the pathogens present in each phenotype differed. Methods MARS recruited critically ill patients from two Dutch ICUs. Only patients meeting sepsis or ARDS diagnostic criteria were included for this analysis. We applied latent class analysis (LCA) to vital signs, clinical laboratory values, and protein biomarkers from Day 1 of ICU admission in 1,485 patients. LCA models with 1-5 classes were fitted. We assigned class membership using the best fitting model and compared characteristics between classes. The present classes’ overlap with prior phenotypes was evaluated by comparison to an extensively validated parsimonious model,2 trained previously to classify molecular phenotypes. Results A two-class model best fit the cohort (VLMR p&lt; .001), and the parsimonious model and multivariate profiles suggested high overlap (AUC=.929) with previously described ‘Hypoinflammatory’ (Class 1; n=895) and ‘Hyperinflammatory’ (Class 2; n=590) phenotypes (Figure 1). Bacteremia was more prevalent in the Hyperinflammatory phenotype (27.2% vs 7.8%; p&lt; .001), with Enterobacteriaceae as the most prevalent species. For primary infection sites, lower respiratory tract was more common in the Hypoinflammatory (56% vs 36%) and abdomen more common in the Hyperinflammatory phenotype (26% vs 9%). Mortality was significantly higher in the Hyperinflammatory phenotype at both 30 days (OR=2.54, CI95%= 2.003—3.235 ) and 90 days (OR=2.41, CI95% = 1.925—3.016; both p&lt; .001). Conclusion In MARS, we identified the previously described Hypo- and Hyperinflammatory phenotypes with divergent host response, pathogen profiles, and outcomes. These findings suggest that host phenotype signatures in part may be driven by sites of infection and pathogen species. Disclosures Lieuwe D.J. Bos, MD-PhD, Astra Zeneca: Advisor/Consultant|CSL Behring: Advisor/Consultant|Impentri: Advisor/Consultant|Novartis: Advisor/Consultant|Scailyte: Advisor/Consultant|Sobi: Advisor/Consultant Pratik Sinha, MBChB/PhD, AstraZeneca: Advisor/Consultant|Prenosis Inc: Board Member Carolyn S. Calfee, MD, Cellenkos: Advisor/Consultant|Gen1e Life Sciences: Advisor/Consultant|Janssen: Advisor/Consultant|NGMBio: Advisor/Consultant|Santhera: Advisor/Consultant|Vasomune: Advisor/Consultant
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Horai, Kayoko, and Elaine Wright. "Raising Awareness: Learning Advising as an In-Class Activity." Studies in Self-Access Learning Journal, June 1, 2016, 197–208. http://dx.doi.org/10.37237/070208.
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Learning advising can play an important role in scaffolding the development of learner autonomy. While a classroom teacher might give advice to students about what and how to study, a learning advisor aims to help students to identify specific needs and create action plans to meet their goals. The teachers and the learning advisors can work hand-in-hand to encourage students to take responsibility for their own learning. For this project, a communicative English course at a Japanese university was modified to include in-class advising sessions. Despite having no English majors, there is a well-curated but underutilized Self Access Learning Center (SALC) that includes three learning advisors. Students are required to learn English but often have limited awareness of the language learning process. The project was designed to increase learner awareness toward their individual learning goals, inform the teacher of students’ goals, and increase student engagement with the SALC. This paper discusses the details of the course in the specific setting, as well as reactions from students, teachers, and learning advisors. The article also gives options for teachers who hope to encourage learner autonomy but may not have access to learning advisors in their institution.
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Denisenko, Anna, Catherine Hafer, and Dimitri Landa. "Competence and advice." American Journal of Political Science, September 7, 2024. http://dx.doi.org/10.1111/ajps.12905.
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AbstractWe develop a theory of policy advice that focuses on the relationship between the competence of the advisor (e.g., an expert bureaucracy) and the quality of advice that the leader may expect. We describe important tensions between these features present in a wide class of substantively important circumstances. These tensions point to the presence of a trade‐off between receiving advice more often and receiving more informative advice. The optimal realization of this trade‐off for the leader sometimes induces her to prefer advisors of limited competence—a preference that, we show, is robust under different informational assumptions. We consider how institutional tools available to leaders affect preferences for advisor competence and the quality of advice they may expect to receive in equilibrium.
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Normington, Charmaine, Emma Clark, Karen Bentley, et al. "P-1830. The First-in-Class Anti-Staphylococcal Antibiotic Afabicin Desphosphono is Not Associated With Clostridioides difficile Infection in an in vitro Human Gut Model." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.1993.
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Abstract Background Antibiotic use is commonly associated with disruption of the healthy human gut microbiota (termed dysbiosis). Dysbiosis can diminish colonisation resistance and increase susceptibility to Clostridioides difficile infection (CDI). Use of the pathogen-specific anti-staphylococcal afabicin was not associated with dysbiosis in animals and healthy volunteers (Nowakowska et al, 2023). Here, we assessed whether this microbiota-sparing property of afabicin would limit CDI in a clinically reflective in vitro human gut model. Methods A well-established gut model was used as described previously (Baines et al, 2005). Four independent models were seeded with human fecal slurry (d0) and inoculated at d14 and d21 with C. difficile spores (107 CFU/mL). Two-week treatments were assessed beginning on d21 including (i) a CDI-positive control antibiotic levofloxacin (149.55 mg/L once daily), (ii) afabicin desphosphono high dose (35.7 mg/L twice daily [BID]), (iii) afabicin desphosphono mid dose (17.9 mg/L BID) and (iv) a vehicle control (1% DMSO BID). Endpoints for the model included facultative and obligate anaerobe counts, total viable and spore C. difficile counts and C. difficile toxin titre and were monitored daily until d63. Results Each of the afabicin desphosphono treated models displayed colonisation resistance and no evidence of C. difficile germination or toxin production for the duration of the study. Further, no relevant changes in major facultative and obligate anaerobe groups were observed, indicating limited dysbiosis, similar to the vehicle control. In contrast, following a pre-treatment period where colonisation resistance was demonstrated (i.e. no germination following C. difficile inoculation), levofloxacin treatment resulted in dysbiosis characterized most notably by reductions (∼5log10 CFU/mL) in facultative anaerobes including lactose fermenting Enterobacteriaceae. Dysbiosis caused by levofloxacin led to CDI including C. difficile germination and toxin production. Conclusion Findings from this study provide further support for the microbiota-sparing property of afabicin and suggest that limited off-target microbiota effects associated with afabicin treatment may reduce incidence of CDI when used clinically. Disclosures Charmaine Normington, PhD, Debiopharm International S.A.: Grant/Research Support Ricardo Chaves, n/a, Debiopharm International S.A.: Salary David Cameron, PhD, Debiopharm International S.A.: Salary Mark H. Wilcox, MD, Astra Zeneca: Advisor/Consultant|Debiopharm International S.A.: Advisor/Consultant|Debiopharm International S.A.: Grant/Research Support|Ferring: Advisor/Consultant|GSK: Advisor/Consultant|GSK: Honoraria|Nestle: Advisor/Consultant|Paion: Advisor/Consultant|Pfizer: Advisor/Consultant|Pfizer: Grant/Research Support|Pfizer: Honoraria|Phico therapeutics: Advisor/Consultant|QPex Biopharma: Advisor/Consultant|Seres: Advisor/Consultant|Seres: Grant/Research Support|Seres: Lecture Fees|Summit: Advisor/Consultant|Summit: Grant/Research Support|The European Tissue Symposium: Advisor/Consultant|The European Tissue Symposium: Grant/Research Support|Tillotts: Advisor/Consultant|Tillotts: Grant/Research Support|Tillotts: Lecture Fees|Vedanta: Advisor/Consultant Caroline Chilton, PhD, Debiopharm International S.A.: Grant/Research Support
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Herrera-Cruz, Joel, and Alejandra Galicia-Escalante. "Sistema web para gestión de estadías profesionales para TSU e Ingeniería." Revista de Simulación Computacional, December 31, 2019, 16–24. http://dx.doi.org/10.35429/jcs.2019.10.3.16.24.
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Professional stays allow students to enter the workplace quickly and acquire knowledge to improve their professional experience. A software tool was developed that allows to manage the process of professional stays of the students of the TSU career and engineering of Information and Communication Universidad Tecnologica del Valle de Toluca, which allows to help improve the care of the academic advisors towards the students to be able to take control of: . 1st and 2nd stay evaluations by academic advisor and external advisor -To be able to upload the stay memories to the online platform - Keep statistical reports on official formats of agreements between school-company-student - Statisticians of the skills that students perform in professional stays to be able to know what is the field where there is more demand and what technologies are currently being used in the industry. - Keep track of the activities that students perform in companies. All of the above with the purpose of seeing the needs of organizations and adapting the knowledge taught in class so that students remain competitive and can enter the world of work.
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Rausch, Ethan, David van Duin, Luther A. Bartelt, and Lindsay M. Daniels. "1430. Eravacycline associated hypofibrinogenemia during treatment of M.abscessus." Open Forum Infectious Diseases 9, Supplement_2 (2022). http://dx.doi.org/10.1093/ofid/ofac492.1259.
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Abstract Background Eravacycline, a novel synthetic fluorocycline, is structurally similar to tigecycline. Cases of tigecycline associated hyperfibrinogenemia have been reported in the literature, however the mechanism is not currently well described. At this time it is unknown if this is a class effect. Methods Two cases of patients on eravacycline for treatment of Mycobacterium abscessus (M.abscessus) who received regular fibrinogen monitoring are described. Results Patient 1 received a kidney transplant (2010) and was admitted for acute hypoxic respiratory failure secondary to COVID-19. Their course was complicated by multiple infections including disseminated M.abscessus with positive cultures from the lung and blood. Eravacycline 1 mg/kg BID (80 mg) was started on D1 and continued through D24. Fibrinogen levels on D1 was 448 mg/dl and on D23 were 120 mg/dl. Eravacycline was stopped and fibrinogen returned to normal range (228 mg/dl) in 5 days. Eravacycline was re-trialed at 80 mg BID and fibrinogen level on D1 was 310 mg/dl and 147 mg/dl on D8. No repeat fibrinogen levels were obtained. Patient 2 was a lung transplant recipient (2019) admitted for treatment of M.abscessus skin and soft tissue infection. The patient was started on eravacycline 1 mg/kg BID (90 mg) due to concerns of hypofibrinogenemia from tigecycline. On D1 of eravacycline fibrinogen was 167 mg/dl , on D19 of therapy fibrinogen was 64 mg/dl and eravacycline was stopped. Fibrinogen level returned to normal 3 days after eravacycline discontinuation (212 mg/dl). Conclusion Similar to tigecycline, we observed eravacycline related hypofibrinogenemia. Time to onset was variable in the two cases presented. Hypofibrinogenemia was readily reversible, within 3-5 days, with drug withdrawal and reproducible in one patient with re-challenge of eravacycline. Further analysis into eravacycline related hypofibrinogenemia and its impact on coagulation outcomes are warranted based on these reports. Disclosures David van Duin, MD, PhD, Achaogen: Advisor/Consultant|Allergan: Advisor/Consultant|Astellas: Advisor/Consultant|MedImmune: Advisor/Consultant|Melinta: Advisor/Consultant|Merck: Advisor/Consultant|Merck: Grant/Research Support|NeuMedicine: Advisor/Consultant|Pfizer: Advisor/Consultant|Qpex: Advisor/Consultant|Roche: Advisor/Consultant|Sanofi-Pasteur: Advisor/Consultant|Shionogi: Advisor/Consultant|Shionogi: Grant/Research Support|T2 Biosystems: Advisor/Consultant|Tetraphase: Advisor/Consultant.
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Kumar, Princy N., Deborah A. Goldstein, Richard L. Hengel, et al. "1581. Weight and Metabolic Changes with Long-Acting Lenacapavir in a Combination Regimen in Treatment-Naïve People with HIV-1 at Week 80." Open Forum Infectious Diseases 10, Supplement_2 (2023). http://dx.doi.org/10.1093/ofid/ofad500.1416.
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Abstract Background Lenacapavir (LEN) is a highly potent, long-acting, first-in-class inhibitor of HIV-1 capsid protein approved for the treatment of HIV-1 infection in adults with multidrug resistance in combination with other antiretrovirals. CALIBRATE is an ongoing phase 2 study in people with HIV-1 (PWH) who are newly initiating treatment. At Week 80 (W80), subcutaneous (SC) and oral LEN, in combination with other antiretrovirals, maintained high rates of virologic suppression. In PWH initiating treatment, weight increases associated with a return to health effect have been observed. This analysis examined weight and metabolic changes to the W80 timepoint. Methods Participants were randomized (2:2:2:1) to 1 of 4 treatment groups (TG). TG1 and TG2 both received SC LEN (927 mg) every 6 months + oral once daily (QD) emtricitabine/tenofovir alafenamide (F/TAF) for 28 weeks, after which virologically suppressed participants continued a 2-drug maintenance regimen: SC LEN (927 mg) with oral QD TAF (TG1) or oral QD bictegravir (BIC) (TG2). TG3 received oral QD LEN + F/TAF, and TG4 received oral QD BIC/F/TAF throughout. The metabolic profile of LEN was assessed from baseline to W28 and after initiating the 2-drug maintenance regimen to W80. Due to the small sample size, no statistical testing was performed. Results 182 participants (7% female, 52% Black) were randomized and dosed (n=52, 53, 52, 25 in TG1 to TG4, respectively). Baseline median age was 29 years; 15% had baseline viral load &gt;100,000 c/mL. Baseline median weight and body mass index (BMI) were 78.2 kg and 25.8 kg/m2, respectively. Weight, BMI, and fasting lipid profiles for each treatment group through W80 are presented (Table). Conclusion In this phase 2 study of treatment-naïve PWH, treatment regimens that included SC or oral LEN in combination with other antiretroviral agents led to expected weight gain and increase in BMI, consistent with the return to health phenomenon, and were not associated with clinically relevant increases in lipids. Disclosures Princy N Kumar, MD, Gilead Sciences, Inc: Grant/Research Support|Gilead Sciences, Inc: Stocks/Bonds|Johnson & Johnson: Advisor/Consultant|Johnson & Johnson: Stocks/Bonds|Merck: Advisor/Consultant|Merck: Grant/Research Support|Merck: Stocks/Bonds|Pfizer: Stocks/Bonds|Theratechnologies: Advisor/Consultant|Theratechnologies: Grant/Research Support|Viiv: Advisor/Consultant|Viiv: Grant/Research Support|Viiv: Stocks/Bonds Aditya H Gaur, MD, Gilead Sciences, Inc (Grant support/CTA with St. Jude): Grant/Research Support|Janssen (Grant support/CTA with St. Jude): Grant/Research Support|Viiv (Grant support/CTA with St. Jude and Serve on Pediatric Advisory Board): Board Member|Viiv (Grant support/CTA with St. Jude and Serve on Pediatric Advisory Board): Grant/Research Support Anson K Wurapa, MD, Gilead Sciences, Inc: Clinical Trial Investigator Ann M. Khalsa, MD, Gilead Sciences, Inc: Advisor/Consultant|Gilead Sciences, Inc: Grant/Research Support|Gilead Sciences, Inc: Honoraria|Glaxo Smith Kline: Advisor/Consultant|Viiv: Advisor/Consultant Cheryl L Newman, MD, Gilead Sciences, Inc: Grant/Research Support|GSK Viiv: Grant/Research Support|GSK Viiv: Honoraria|Janssen: Grant/Research Support|Merck: Grant/Research Support Gary Saunders, BSc, Gilead Sciences, Inc: Employee|Gilead Sciences, Inc: Stocks/Bonds Shan-Yu Liu, PhD, Gilead Sciences, Inc: Employee|Gilead Sciences, Inc: Stocks/Bonds Hadas Dvory-Sobol, PhD, Gilead Sciences, Inc: Employee|Gilead Sciences, Inc: Stocks/Bonds Martin Rhee, MD, Gilead Sciences, Inc: Employee|Gilead Sciences, Inc: Stocks/Bonds Samir K. Gupta, MD, Gilead Sciences: Advisor/Consultant|ViiV Healthcare: Advisor/Consultant|ViiV Healthcare: Grant/Research Support