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Journal articles on the topic 'Class IV therapeutic LASER'

Author: Grafiati

Published: 21 April 2022

Last updated: 30 July 2025

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1

Roberts, Delia B., Roger J. Kruse, and Stephen F. Stoll. "The Effectiveness of Therapeutic Class IV (10 W) Laser Treatment for Epicondylitis." Lasers in Surgery and Medicine 45, no. 5 (2013): 311–17. http://dx.doi.org/10.1002/lsm.22140.

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Roberts, Delia, Roger Kruse, Matthew Petznick, Jacklyn Kiefer, Peter Alaskym, and Stephen Stoll. "A Randomized Controlled Trial for the Efficacy of Therapeutic Class IV Laser Treatment for Tendinosis." Medicine & Science in Sports & Exercise 42 (May 2010): 397. http://dx.doi.org/10.1249/01.mss.0000384737.43363.3c.

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Luna, Stelio Pacca Loureiro, Allen Schoen, Pedro Henrique Esteves Trindade, and Paula Barreto da Rocha. "Penetration Profiles of a Class IV Therapeutic Laser and a Photobiomodulation Therapy Device in Equine Skin." Journal of Equine Veterinary Science 85 (February 2020): 102846. http://dx.doi.org/10.1016/j.jevs.2019.102846.

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4

Shrestha, Diggaj, and Sunita Sharma. "Comparison of the clinical effectiveness of Class IV Laser therapy and therapeutic ultrasound in patients with chronic neck pain: a randomized controlled trial." Revista Pesquisa em Fisioterapia 14 (June 3, 2024): e5538. http://dx.doi.org/10.17267/2238-2704rpf.2024.e5538.

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INTRODUCTION: Chronic neck pain (CNP) is a common musculoskeletal problem that affects a large proportion of the population and lasts longer than three months. It has a high cost in terms of life, disability, and healthcare. Several modalities have effectively provided immediate and long-term relief for CNP; however, the comparative clinical effectiveness of these modalities is limited. OBJECTIVES: The study aimed to determine the clinical effectiveness of Class IV Laser therapy and Therapeutic Ultrasound (TUS) in patients with CNP. METHODS AND MATERIALS: Forty-four patients with CNP of both g

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Indolia, Jugendra Singh, and Prof Dr Sajjad Alam. "Class IV Laser Therapy And NMES In Stroke Rehabilitation: A Comparative Study Of Upper Limb Motor Control Improvements In Chronic Stroke Patients." International Journal of Environmental Sciences 11, no. 5s (2025): 1257–64. https://doi.org/10.64252/rdrb2g58.

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Background: Stroke is a leading cause of chronic disability, with upper limb motor impairments being among the most persistent and functionally limiting consequences. These deficits often remain even after standard rehabilitation, particularly in patients more than six months post- stroke. Novel interventions like Class IV Laser Therapy and Neuromuscular Electrical Stimulation (NMES) are gaining traction due to their potential to promote neuroplasticity and improve motor outcomes. While Laser Therapy is thought to accelerate tissue repair and reduce inflammation, NMES activates paretic muscles

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Abdelatief, Emad Eldin Mohamed, and Karim Ahmed Fathy. "Effect of class IV laser therapy and Pilates exercises on bone density and pain in primary osteoporosis: a randomised controlled trial." International Journal of Therapy and Rehabilitation 28, no. 9 (2021): 1–14. http://dx.doi.org/10.12968/ijtr.2021.0053.

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Background/aims Osteoporosis is a systemic disorder characterised by a decrease in bone quality and density. This causes the bones to become weak and unable to withstand mild stresses, and the associated pain is made worse with activities. The aim of this study was to investigate the effect of class IV laser therapy and Pilates exercises on bone mineral density and pain in patients with primary osteoporosis. Methods A total of 60 patients with osteoporosis (40 women and 20 men) participated in this study. Their age ranged between 40 and 60 years. They were allocated randomly to three groups: G

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Gavrilenko, Tetiana І., Oleksandr M. Lomakovskyi, Olena A. Pidgaina, Olga V. Rasputniak, Nataliia O. Ryzhkova, and Natalia V. Grechkovskaya. "Immunological Reactivity and Intensity of Oxidative Stress in Stable Coronary Artery Disease." Ukrainian Journal of Cardiovascular Surgery 31, no. 3 (2023): 22–30. http://dx.doi.org/10.30702/ujcvs/23.31(03)/gl008-2230.

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The aim. To analyze the relationship between immune response factors and the intensity of oxidation of lipoproteins and proteins in patients with stable coronary artery disease (CAD) to clarify the pathogenesis of coronary atherosclerosis. Materials and methods. A total of 179 patients with stable CAD of II-IV functional class, mean age 56 (49-62) years (main group) and 30 healthy individuals, mean age 49 (45-53) years (control group) were examined. The material for immunological research was peripheral venous blood. To determine the indicators of immunity, flow laser cytometry and enzym

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Ottaviani, Giulia, Margherita Gobbo, Rossana Bussani, Serena Zacchigna, Roberto Di Lenarda, and Biasotto Matteo. "OI0311 Class IV laser biostimulation and tumor angiogenesis." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117, no. 5 (2014): e389-e390. http://dx.doi.org/10.1016/j.oooo.2014.01.217.

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9

Carroll, James D. "Significant Errors and Misdirection in Class IV Laser Therapy Study." American Journal of Pathology 184, no. 4 (2014): 1251. http://dx.doi.org/10.1016/j.ajpath.2013.11.033.

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Omeed, M. Memar MD PhD, Caughlin MD Benjamin, and Djalilian MD Hamid. "Low Level Laser Treatment for Patterned Hair Loss: A Systematic Review." Archives of Dermatology and Skin Care 1, no. 2 (2018): 20–24. https://doi.org/10.5281/zenodo.2250507.

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  <strong>LOW LEVEL LASER TREATMENT FOR PATTERNED HAIR</strong><strong> LOSS: A    SYSTEMATIC REVIEW</strong>   Omeed Memar<sup>1*</sup>, Benjamin Caughlin<sup>2</sup>, Hamid Djalilian<sup>3</sup> 1 Academic Dermatology & Skin Cancer Institute, Chicago, Illinois 2 Department of Surgery / Division of Otolaryngology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois. Division of Facial Plastic and Reconstructive Surgery, Jesse Brown VAMC, Chicago, Illinois. Division of Facial Plastic and Reconstructive Surgery, University of Illinois Health Hospital Sys

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Parr, Jeffrey J., Kelly A. Larkin, and Paul A. Borsa. "Effects of Class IV Laser Therapy on Exercise-Induced Muscle Injury." Athletic Training & Sports Health Care 2, no. 6 (2010): 267–76. http://dx.doi.org/10.3928/19425864-20100630-04.

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12

Ottaviani, Giulia, Margherita Gobbo, Mauro Sturnega, et al. "Effect of Class IV Laser Therapy on Chemotherapy-Induced Oral Mucositis." American Journal of Pathology 183, no. 6 (2013): 1747–57. http://dx.doi.org/10.1016/j.ajpath.2013.09.003.

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13

Kumar, Sanjiv. "Effect of Class IV LASER on Bell's Palsy: A case series." Indian Journal of Physical Therapy and Research 1, no. 1 (2019): 55. http://dx.doi.org/10.4103/ijptr.ijptr_15_19.

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van Willigen, Marcel, Annelotte M. Vonk, Hui Ying Yeoh, et al. "Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants." Life Science Alliance 2, no. 1 (2019): e201800172. http://dx.doi.org/10.26508/lsa.201800172.

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Cystic fibrosis is caused by mutations in the CFTR gene, which are subdivided into six classes. Mutants of classes III and IV reach the cell surface but have limited function. Most class-III and class-IV mutants respond well to the recently approved potentiator VX-770, which opens the channel. We here revisited function and folding of some class-IV mutants and discovered that R347P is the only one that leads to major defects in folding. By this criterion and by its functional response to corrector drug VX-809, R347P qualifies also as a class-II mutation. Other class-IV mutants folded like wild

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15

Khadayat, Sarita, and Ankit Kumar. "Efficacy of Class IV LASER Therapy and Sensory Re-education in Patients with Diabetic Neuropathy: A Case Report." Journal of Diabetology 16, no. 1 (2025): 83–86. https://doi.org/10.4103/jod.jod_153_24.

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Abstract Diabetic neuropathy (DN) is a common complication of chronic diabetes mellitus, which is prevalent worldwide. We intend to measure the result of class IV LASER therapy (LT) and sensory re-education (SR) in improving sensory levels in patients with DN. The neurological physiotherapist assessed the nerve conduction velocity (NCV) of the tibial and peroneal nerves on the 50-year-old female patient, who had been diagnosed with DN by her primary care neurologist. Monofilament testing was conducted on 10 locations on the dorsal and plantar aspects of both feet. Following that, class IV LT w

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Jangra, Mandeep Kumar, Mehroz Ahmed Mirza, and Manu Goyal. "Class IV Laser Therapy as an Adjunct to Primary Percutaneous Coronary Intervention in Individuals with Acute Coronary Syndrome: A Feasibility Pilot Study." Biomedical and Biotechnology Research Journal 8, no. 1 (2024): 87–91. http://dx.doi.org/10.4103/bbrj.bbrj_286_23.

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Background: Acute coronary syndrome (ACS) is the most severe clinical condition of coronary artery disease, and early reperfusion of the ischemic myocardium is the most important and standardized treatment for it. Unfortunately, reperfusion also leads to myocardial reperfusion injury (RI). Photobiomodulation/laser therapy has been found to be effective in limiting myocardial RI in a number of animal studies. This study aims to assess the feasibility and cardio-protective effects of Class IV laser therapy among patients with ACS who underwent primary percutaneous coronary intervention (pPCI). M

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Zielińska, Paulina, Maria Soroko, Anna Zwyrzykowska, and Zdzisław Kiełbowicz. "The use of laser biostimulation in human and animal physiotherapy – a review." Acta Veterinaria Brno 86, no. 1 (2017): 91–96. http://dx.doi.org/10.2754/avb201786010091.

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Laser biostimulation involves applying a laser beam to the tissue to facilitate healing and regenerative processes. Laser therapy is one of the most important physical methods used in human physiotherapy. In veterinary medicine, laser therapy is a new and so far poorly examined method. The results of studies conducted so far are very promising, yet the positive effect of laser light, especially that of class IV, has yet to be confirmed. This article presents an overview of the available literature on the effect of laser treatment on the human and animal organism.

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Chermetz, Maddalena, Margherita Gobbo, Giulia Ottaviani, Serena Zacchigna, Roberto Di Lenerda, and Matteo Biasotto. "OI0308 Class IV laser therapy in pediatrics affected by chemotherapy-induced oral mucositis." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117, no. 5 (2014): e335-e336. http://dx.doi.org/10.1016/j.oooo.2014.01.034.

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19

Roberts, Delia, Roger Kruse, Matthew Petznick, Jacklyn Kiefer, and Peter Alasky. "The Efficacy of Class IV Laser Treatment for Epicondylitis; A Randomised Controlled Trial." Medicine & Science in Sports & Exercise 43, Suppl 1 (2011): 498–99. http://dx.doi.org/10.1249/01.mss.0000401375.23524.ce.

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20

Kumar, Sachin, Ramneek Kaur, Rashi Rajput, and Manisha Singh. "Bio Pharmaceutics Classification System (BCS) Class IV Drug Nanoparticles: Quantum Leap to Improve Their Therapeutic Index." Advanced Pharmaceutical Bulletin 8, no. 4 (2018): 617–25. http://dx.doi.org/10.15171/apb.2018.070.

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Purpose: Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead. Therefore, in present study Chitosan is opted for encapsulating the BCS class IV drug (Hydrochlorothiazide) to attain better stability, enhanced permeabi

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de la Barra Ortiz, Hernán Andrés, Sebastián Acevedo Cangas, Antonio Cumio Herrera, Felipe Oñate García, and Sebastián Velásquez Velásquez. "Efficacy of class IV laser in the management of musculoskeletal pain: a systematic review." Physiotherapy Quarterly 29, no. 2 (2021): 1–11. http://dx.doi.org/10.5114/pq.2021.105882.

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22

Pappa, M., M. Kosmetatou, A. Pieta, et al. "POS1152 ATTAINMENT OF EULAR/ERA-EDTA TREATMENT TARGETS IN THE FIRST YEAR IN LUPUS NEPHRITIS: A MULTICENTER OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 907.1–907. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2599.

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BackgroundThe approval of two new drugs, belimumab and voclosporin, in lupus nephritis (LN) over the last years has raised questions regarding their place in the therapeutic algorithm of LN. Their use in initial regimens or in refractory/relapsed disease depends on disease outcomes with current standard of care (SoC) therapies.ObjectivesTo calculate EULAR/ERA-EDTA renal response rates with SoC therapies at 3, 6 and 12 months, as well as rates of successful tapering to the recommended glucocorticoid use at 6 months in real-life clinical settings.MethodsCombined retrospective and prospective (20

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Chijiwa, H., H. Mihashi, K. Sakamoto, H. Umeno, and T. Nakashima. "Supraglottic carcinoma treatment results analysed by therapeutic approach." Journal of Laryngology & Otology 123, S31 (2009): 104–7. http://dx.doi.org/10.1017/s0022215109005192.

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AbstractThis study reviewed 161 patients with supraglottic squamous cell carcinoma who underwent radical therapy at Kurume University Hospital between 1989 and 2003. The five-year survival rate was 89 per cent in patients with stage III disease and 75 per cent in stage IV patients, thus demonstrating favourable results even for patients with advanced cancer. The five-year local control rate and the laryngeal preservation rate were poor in patients with T3 tumours (being 75 per cent for both), but the overall five-year local control rate for all patients was 86 per cent. Laser surgery plus chem

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Yenen, Zeynep, and Jale Görücü. "An in Vitro Study on The Effects of Er, Cr: Ysgg Laser on The Enamel and Dentin Morphology and Microleakage." Cumhuriyet Dental Journal 28, no. 1 (2025): 36–44. https://doi.org/10.7126/cumudj.1465957.

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Objectives: The evaluation of the enamel and dentin cavity surface morphologies by Scanning Electron Microscopy (SEM) in Class II occlusogingival slot cavities which were prepared and etched by Er, Cr: YSGG (Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet) laser and assessing their effects on the microleakage at composite resin restorations, and also comparing them with those of traditional methods. Material and Methods: Fifty-five non-carious, sound extracted human molar teeth were divided into five groups: bur preparation + acid etching (Group I), bur preparation + laser etching (Group

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Musilli, Marino, Morena Tina Iuorio, Emanuele Vaia, Enzo Vaia, Luca Ramaglia, and Vincenzo D’Antò. "Biomechanically and Periodontally-Based Orthodontic Treatment of a Patient with Upper Canine Affected by External Cervical Resorption (ECR): A Case Report." Dentistry Journal 11, no. 12 (2023): 278. http://dx.doi.org/10.3390/dj11120278.

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(1) Background: Orthodontic treatment may be a potential predisposing factor for ECR. The affected tooth goes to ankylosis, which could lead to a malocclusion. Although teeth severely affected by ECR (class IV Heithersay) are usually extracted, this case report aims to present the use of an ECR class IV upper canine, both as ankylosed to solve the malocclusion and the occlusal plane canting, as well as not ankylosed to correct its ridge defect with orthodontic extrusion. (2) Methods: A 14-year-old male, complaining of an ugly smile and a failed orthodontic attempt to recover an impacted canine

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Stroie, Anna Mirela, Mircea Niculae Penescu, Nicoleta Petre, and Geanina Beldea. "Particularities of the Evolution and Therapeutic Response in Men with Systemic Lupus Erythematosus and Lupus Nephritis." Internal Medicine 16, no. 6 (2019): 7–17. http://dx.doi.org/10.2478/inmed-2019-0089.

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AbstractAim. The prevalence ratio of systemic lupus erythematosus in men compared to women is 1:10, with more aggressive forms in men and in children. The incidence of lupus nephritis is of 50-60% in patients with lupus.In this paper, we aim to report on a series of cases that include male patients who had lupus nephritis via renal biopsy and were admitted between January 2011 - December 2017, with or without other SLE manifestations. The aim is to review the particularities and the therapeutic response: age at onset, disease duration, lupus nephritis class, extra-renal organ involvement of lu

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Kini, Annapoorna, Prerana Kothari, R. Sujith, Nithin Shetty, Blesy K. Varughese, and Sheetal C. Kasargod. "Comparative Evaluation of Clinical and Microbiological Assessment of Caries Excavation Using Conventional, Smart Bur, Chemomechanical Method and ErCr:YSGG Laser." Journal of Pharmacy and Bioallied Sciences 16, Suppl 3 (2024): S2830—S2832. http://dx.doi.org/10.4103/jpbs.jpbs_315_24.

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ABSTRACT Objectives: Caries removal efficacy in terms of microbiological burden using Tungsten Carbide Bur No. 330, Polymer bur, BRIX 3000, and ErCr:YSGG Laser. Methods: Class I open dentinal caries was selected and divided into four groups (n = 15) depending on caries excavation methods. Group I: Tungsten carbide (TC) No 330-bur; Group II: Polymer bur (Smart bur); Group III: Brix 3000 gel; Group IV: Erbium, chromium-doped yttrium, scandium, gallium, and garnet (Er:Cr:YSGG) laser. Two samples of carious material, before and after caries excavation, were taken and cultured on blood agar plates.

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Panton, Lynn, Emily Simonavice, Kristen Williams, et al. "Effects of Class IV Laser Therapy on Fibromyalgia Impact and Function in Women with Fibromyalgia." Journal of Alternative and Complementary Medicine 19, no. 5 (2013): 445–52. http://dx.doi.org/10.1089/acm.2011.0398.

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Williams, Kristen, Reed Mathis, J. Derek Kingsley, et al. "Effects of Class IV Laser Therapy on Disease Impact and Function in Women with Fibromyalgia." Medicine & Science in Sports & Exercise 42 (May 2010): 155. http://dx.doi.org/10.1249/01.mss.0000386418.18238.0e.

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Novotny, Mark J., and H. Richard Adams. "New perspectives in cardiology: Recent advances in antiarrhythmic drug therapy." Journal of the American Veterinary Medical Association 189, no. 5 (1986): 533–39. https://doi.org/10.2460/javma.1986.189.05.533.

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SUMMARY During the past decade, advances in basic and applied cardiology have led to the introduction of several new antiarrhythmic drugs that have distinct clinical advantages over their older counterparts. These therapeutic advantages comprise either a more favorable pharmacokinetic disposition in the patient or new and perhaps novel mechanisms of antiarrhythmic actions. The class IV agent verapamil, for example, selectively blocks the slow inward Ca++ current in excitable tissues and this action is proving to be quite effective in controlling supraventricular tachyarrhythmias. Tocainide is

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Dee, Brian M., and Michael L. Thomas. "Safety and Efficacy of a High-Intensity, Weight-Based, Intravenous Heparin Protocol Revision in Patients who are Obese." Hospital Pharmacy 43, no. 11 (2008): 895–902. http://dx.doi.org/10.1310/hpj4311-895.

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Purpose Data collected previously within this institution concluded that the initial heparin infusion rate in the high-intensity, weight-based, intravenous (IV) heparin protocol should be adjusted from 18 to 15 units/kg/h (based on actual body weight) in patients who are more than 50% above ideal body weight (IBW). The purpose of this study was evaluation of the safety and efficacy of the revised protocol. Methods A retrospective chart review was conducted from the initiation of the revised protocol on October 28, 2006, through March 15, 2007. All patients receiving high-intensity, weight-base

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Sadick, N. S., and L. Sorhaindo. "An evaluation of post-sclerotherapy laser compression and its efficacy in the treatment of leg telangiectasias." Phlebology: The Journal of Venous Disease 21, no. 4 (2006): 191–94. http://dx.doi.org/10.1258/026835506779115771.

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Objective: The use of graduated compression stockings is presently indicated in both surgical and non-surgical treatment of varicose veins. The role that it plays in therapeutic efficacy or the complication profile is yet to be determined. The present study examined the role of compression in the treatment of class I–II venulectasia, utilizing the Pulsed Dye Laser. Methods: Thirteen patients with leg vein size 0.5–1.0 mm in diameter were treated with the Long-Pulse Tuneable Dye Laser (Vbeam®). A surface area of 5 cm2 of vessels on bilaterally symmetric thighs was treated. Class II compression

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Nopratilova, Eksanti Indriani Sabila, Dedi Nugroho, Rizky Farmasita Budiastuti, Alhara Yuwanda, and Anugerah Budipratama Adina. "Evaluasi Kualitas Informasi Obat Pada Brosur Obat." Jurnal Sains Farmasi Dan Kesehatan 2, no. 1 (2024): 74–86. https://doi.org/10.62379/jfkes.v2i1.1527.

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The research aims to describe the information in drug brochures. Classification of drug brochures: categorization of drugs based on labeling, name, product origin and therapeutic class. The study also assesses the completeness of information in drug brochures, following Indonesian Ministry of Health regulations (Number: 386/MENKES/SK/IV/1994), Indonesian National Agency of Drug and Food Control (BPOM) regulations (Number 2 of 2021) and WHO Ethical Criteria for Medicinal Drug Promotion in 1988. This descriptive study uses simple random sampling with a sample size of 30 drug brochures. Research

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Yao, Yuan, Xiu Wang, Wenhan Hu, et al. "Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Hypothalamic Hamartoma: Surgical Approach and Treatment Outcomes." Journal of Clinical Medicine 11, no. 21 (2022): 6579. http://dx.doi.org/10.3390/jcm11216579.

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Hypothalamic hamartoma (HH) is a rare lesion consisting of normal neurons and neuroglia arranged in an abnormal pattern which usually causes gelastic seizures (GS). Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has been developed as a minimally invasive approach to treat HH and gradually become a first-line treatment. In total, this study enrolled 47 consecutive HH patients that underwent one round of ablation. Patients were followed for at least one year. Patients’ medical records and surgical information were carefully reviewed, and univariate analyses were performed

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Larkin, Kelly A., Jeffrey S. Martin, Elizabeth H. Zeanah, Jerry M. True, Randy W. Braith, and Paul A. Borsa. "Limb Blood Flow After Class 4 Laser Therapy." Journal of Athletic Training 47, no. 2 (2012): 178–83. http://dx.doi.org/10.4085/1062-6050-47.2.178.

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Context: Laser therapy is purported to improve blood flow in soft tissues. Modulating circulation would promote healing by controlling postinjury ischemia, hypoxia, edema, and secondary tissue damage. However, no studies have quantified these responses to laser therapy. Objective: To determine a therapeutic dose range for laser therapy for increasing blood flow to the forearm. Design: Crossover study. Setting: Controlled laboratory setting. Patients or Other Participants: Ten healthy, college-aged men (age = 20.80 ± 2.16 years, height = 177.93 ± 3.38 cm, weight = 73.64 ± 9.10 kg) with no curre

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Gotovsky, D. G., V. V. Petrov, K. S. Shchyhelskaya, and E. V. Romanova. "TOXICOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY OF THE VETERINARY DRUG “MASTILACT LC” AT MASTITES IN COWS." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 57, no. 1 (2021): 17–20. http://dx.doi.org/10.52368/2078-0109-2021-57-1-17-20.

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Toxicological properties were studied and production tests were conducted of a veterinary drug “Mastilact LC”. The findings show that by the indicators of acute intragastric toxicity, the drug is referred to the IV class of danger. The therapeutic efficacy of the drug was 87.5%, the course of treatment averaged from 3.25±0.16 to 4.88±0.30 days, depending on the form of mastitis. The drug possesses no negative impact on animal body.

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Brown, Timothy, Alireza Mansouri, Samer Zammar, and Michael Glantz. "CLRM-11. BENCH TO BEDSIDE NEURO-ONCOLOGY: ADVOCATING FOR A CLINICALLY RELEVANT STRATEGY AS UNDERSCORED BY THE PANDEMIC." Neuro-Oncology Advances 3, Supplement_4 (2021): iv3. http://dx.doi.org/10.1093/noajnl/vdab112.010.

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Abstract INTRODUCTION The basic science research endeavor has been abundantly and astonishingly successful in the last three decades in elucidating the mechanisms of neuro-oncologic disease and in suggesting therapeutic strategies. Clinical successes have lagged behind, and translation of promising laboratory findings into clinical practice is rare. We hypothesize that one important reason for this discordance is the use of different paradigms for designing laboratory and clinical trials, and that utilizing clinically relevant procedures could improve laboratory study impact. METHODS We identi

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Chon, Andrew H., Huyen Q. Pham, and Ramen H. Chmait. "Twin-Twin Transfusion Syndrome Complicated by Proximate Placental Cord Insertion Sites: Endoscopic Clip-Assisted Laser Occlusion." Fetal Diagnosis and Therapy 47, no. 10 (2020): 779–84. http://dx.doi.org/10.1159/000509235.

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<b><i>Introduction:</i></b> Severe twin-twin transfusion syndrome (TTTS) with a large vascular communication between proximate placental cord insertion sites is a therapeutic dilemma because laser ablation may cause thermal injury to the cord roots and subsequent fetal demise. <b><i>Case Presentation:</i></b> Stage IV TTTS with placental cord insertion sites 1.3 cm apart and with an intervening large arterio-arterial (AA) anastomosis presented for treatment. The application of endoclips onto the large AA anastomosis between the cord roots allowed

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Park, Kwijun, Hiroshi Itoh, Kenichi Yamahara, et al. "Therapeutic Potential of Atrial Natriuretic Peptide Administration on Peripheral Arterial Diseases." Endocrinology 149, no. 2 (2007): 483–91. http://dx.doi.org/10.1210/en.2007-1094.

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Peripheral arterial diseases are caused by arterial sclerosis and impaired collateral vessel formation, which are exacerbated by diabetes, often leading to leg amputation. We have reported that an activation of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway accelerated vascular regeneration and blood flow recovery in murine legs, for which ischemia had been induced by a femoral arterial ligation as a model for peripheral arterial diseases. In this study, ip injection of carperitide, a human recombinant atrial natriuretic peptide, accelerated blood flow recovery with increa

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Renwick, S. Michelle, Alasdair I. Renwick, David C. Brodbelt, John Ferguson, and Humberto Abreu. "Influence of class IV laser therapy on the outcomes of tibial plateau leveling osteotomy in dogs." Veterinary Surgery 47, no. 4 (2018): 507–15. http://dx.doi.org/10.1111/vsu.12794.

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Medina-Porqueres, Ivan, and Raquel Cantero-Tellez. "Class IV laser therapy for trapeziometacarpal joint osteoarthritis: Study protocol for a randomized placebo-controlled trial." Physiotherapy Research International 23, no. 2 (2018): e1706. http://dx.doi.org/10.1002/pri.1706.

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Tackett, Kimberly L., and Gregory V. Stajich. "Combination Pharmacotherapy in the Treatment of Pulmonary Arterial Hypertension." Journal of Pharmacy Practice 26, no. 1 (2013): 18–28. http://dx.doi.org/10.1177/0897190012466046.

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Pulmonary arterial hypertension (PAH) is a disorder of the small pulmonary arteries characterized by progressive fibrotic and proliferative changes that result in an increased pulmonary vascular resistance. It is a progressive and debilitating disease that leads to right ventricular dysfunction, impairment in activity tolerance and eventually right-sided heart failure, and premature death. The treatment goals for PAH include improvement in symptoms, improvement in functional class and exercise class, decreased morbidity, and preventing mortality. Combination therapy in the treatment of PAH is

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Bhagwat, Ajay, Rohit Doke Doke, Santosh Ghule, and Bipin Gandhi. "Development of nanoparticles for the Novel anticancer therapeutic agents for Acute Myeloid Leukemia." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 4 (2023): 6894–906. http://dx.doi.org/10.37285/ijpsn.2023.16.4.7.

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Acute myeloid leukaemia is becoming more predominant in blood cancer in geriatrics people groups. In 2017, four new therapeutic candidates have been approved by the FDA: Enasidenib, CPX 351, Midostaurin, and Gemtuzumab ozogamicin; with the approval of Venetoclax and Daurismo, additional advances were achieved in 2018. Ivosidenib and gilteritinib were also accepted as single-agent therapy in persistent and recurrent AML 2018. Most of the anticancer drugs belong to Biopharmaceutical classification system-II (BSC), and BCS class-IV has poor bioavailability because of solubility issues. We will ov

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Bockstahler, B. A., D. A. Hulse, S. Carmichael, and W. G. Marshall. "A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog." Veterinary and Comparative Orthopaedics and Traumatology 22, no. 05 (2009): 339–45. http://dx.doi.org/10.3415/vcot-08-08-0069.

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SummaryObesity is an increasingly important health problem for both man and dog. Osteoarthritis (OA) is a significant cause of pain and disability in both species. A link between obesity and OA has been established in man, though the exact mechanism of the relationship remains to be fully elucidated – current research supports both biomechanical and biochemical theories. There is good evidence (class I*) to support weight loss as an effective treatment for human knee OA. In the dog, the relationship is just beginning to be investigated. The results of one study in dogs (class IV evidence*) sug

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Mehrbod, Parvaneh, Dorota Hudy, Divine Shyntum, Jarosław Markowski, Marek J. Łos, and Saeid Ghavami. "Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus." Biomolecules 11, no. 1 (2020): 10. http://dx.doi.org/10.3390/biom11010010.

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The medical burden caused by respiratory manifestations of influenza virus (IV) outbreak as an infectious respiratory disease is so great that governments in both developed and developing countries have allocated significant national budget toward the development of strategies for prevention, control, and treatment of this infection, which is seemingly common and treatable, but can be deadly. Frequent mutations in its genome structure often result in resistance to standard medications. Thus, new generations of treatments are critical to combat this ever-evolving infection. Plant materials and

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Zhong, Zicheng, Yanling Lan, Jinxing Chen, et al. "Optimizing Paclitaxel Oral Absorption and Bioavailability: TPGS Co-Coating via Supercritical Anti-Solvent Fluidized Bed Technology." Pharmaceuticals 17, no. 4 (2024): 412. http://dx.doi.org/10.3390/ph17040412.

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Supercritical anti-solvent fluidized bed (SAS-FB) coating technology has the advantages of reducing particle size, preventing high surface energy particle aggregation, improving the dissolution performance and bioavailability of insoluble drugs. The poor solubility of Biopharmaceutics Classification System (BCS) class IV drugs poses challenges in achieving optimal bioavailability. Numerous anti-cancer drugs including paclitaxel (PTX) belong to the BCS class IV, hindering their therapeutic efficacy. To address this concern, our study explored SAS-FB technology to coat PTX with D-α-tocopherol po

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van der Wegen-Franken, C. P. M., P. Mulder, B. Tank, and H. A. M. Neumann. "Variation in the dynamic stiffness index of different types of medical elastic compression stockings." Phlebology: The Journal of Venous Disease 23, no. 2 (2008): 77–84. http://dx.doi.org/10.1258/phleb.2007.006018.

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Objectives To calculate the dynamic stiffness index (DSI) of 18 different brands of medical elastic compression stockings (MECS). Methods In all, 18 different brands of MECS that were divided into five categories (class II round-knitted, class II flat-knitted, class III round-knitted, class III flat-knitted and class IV flat-knitted MECS) were tested. The static pressure and dynamic pressure pulsations at the B1 level were measured with a newly developed dynamic pressure-determining device. The DSI was calculated. Results The DSI of all 18 brands of MECS showed higher values compared with the

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Martins, Luis, Álvaro Ribeiro, Maria Do Céu Almeida, and João Alves e Sousa. "Bringing optical metrology to testing and inspection activities in civil engineering." ACTA IMEKO 10, no. 3 (2021): 108. http://dx.doi.org/10.21014/acta_imeko.v10i3.1059.

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<p class="Abstract">Optical metrology has an increasing impact on observation and experimental activities in Civil Engineering, contributing to the Research and development of innovative, non-invasive techniques applied in testing and inspection of infrastructures and construction materials to ensure safety and quality of life. Advances in specific applications are presented in the paper, highlighting the application cases carried out by LNEC (the Portuguese National Laboratory for Civil Engineering). </p><p class="Abstract">The examples include: (i) structural monitoring of

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Gioga, Cherana, Raluca Monica Comăneanu, and Doina Lucia Ghergic. "Combined therapeutic possibilities in stage I osteonecrosis of the jaw." Romanian Journal of Stomatology 61, no. 2 (2015): 195–98. http://dx.doi.org/10.37897/rjs.2015.2.16.

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Osteonecrosis of the jaw (ONJ) is a serious complication of bisphosphonate therapy administered to treat conditions such as osteoporosis, Paget’s disease or bone metastases. In this article we present the case of a patient with complex pathology, suffering breast cancer surgery, who performed IV treatment with Zometa for 1 year postoperative. The patient developed ONJ in the mandibular frontal region and has experienced numerous episodes of acute infectious. In the first months of the onset disease were applied non-invasive topical treatments without success, followed by multiple surgeries to

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Reza Pahlevi, Muhamad, Iyan Sopyan, and Dolih Gozali. "Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 9, no. 2 (2023): 147–64. http://dx.doi.org/10.22487/j24428744.2023.v9.i2.15969.

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Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal

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