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Relevant bibliographies by topics / Clastogenia

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Journal articles

Academic literature on the topic 'Clastogenia'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Journal articles on the topic "Clastogenia"

1

Heindorff, K., R. Rieger, A. Michaelis, and S. Takehisa. "Clastogenic adaptation triggered by S-phase-independent clastogens in Vicia faba." Mutation Research Letters 190, no. 2 (1987): 131–35. http://dx.doi.org/10.1016/0165-7992(87)90044-3.

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2

Bryce, Steven M., Stephen D. Dertinger та Jeffrey C. Bemis. "Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity". Mutagenesis 36, № 3 (2021): 255–64. http://dx.doi.org/10.1093/mutage/geab014.

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Abstract The desire for in vitro genotoxicity assays to provide higher information content, especially regarding chemicals’ predominant genotoxic mode of action, has led to the development of a novel multiplexed assay available under the trade name MultiFlow®. We report here on an experimental design variation that provides further insight into clastogens’ genotoxic activity. First, the standard MultiFlow DNA Damage Assay—p53, γ H2AX, phospho-histone H3 was used with human TK6 lymphoblastoid cells that were exposed for 24 continuous hours to each of 50 reference clastogens. This initial analys

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3

Dokal, I., J. Bungey, P. Williamson, D. Oscier, J. Hows, and L. Luzzatto. "Dyskeratosis congenita fibroblasts are abnormal and have unbalanced chromosomal rearrangements." Blood 80, no. 12 (1992): 3090–96. http://dx.doi.org/10.1182/blood.v80.12.3090.bloodjournal80123090.

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Dyskeratosis congenita (DC) is a rare inherited disorder characterized by bone marrow failure, dystrophic changes in the skin and mucous membranes, and a predisposition to malignancy. The DC locus has been mapped to Xq28. The primary defect responsible for this disease remains unknown. We have studied four patients with this disease, three from one family and one from another. In all four patients, primary skin fibroblast cultures were abnormal both in morphology (polygonal cell shape, ballooning, and dendritic-like projections) and in growth rate (doubling time about twice normal). Fibroblast

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4

Grisolia, Cesar Koppe, and Célia Maria Torres Cordeiro. "Variability in micronucleus induction with different mutagens applied to several species of fish." Genetics and Molecular Biology 23, no. 1 (2000): 235–39. http://dx.doi.org/10.1590/s1415-47572000000100041.

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Fish are often used for screening genotoxicity of water. For such programs, a knowledge of the sensitivity to clastogens, spontaneous micronucleus frequency and cell cycle kinetics of the target tissue is necessary. To investigate the pattern of inter-specific sensitivity to micronucleus induction three species of fish, Tilapia rendalli, Oreochromis niloticus and Cyprinus carpio, were exposed to the clastogens bleomycin (BLM), cyclophosphamide (CP), 5-fluorouracil (5-FU), and mitomycin C (MMC). The binucleate/mononucleate ratio in peripheral erythrocytes exposed to cytochalasin B was also used

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5

Hamada, K., T. Kumazaki, K. Mizuno, and K. Yokoro. "A small nuclear RNA, U5, can transform cells in vitro." Molecular and Cellular Biology 9, no. 10 (1989): 4345–56. http://dx.doi.org/10.1128/mcb.9.10.4345.

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Low-molecular-weight RNA exhibiting transforming potential was identified in chemically induced lymphoma cells by the transformation of mink lung cells after transfection. The RNA was sequenced by the direct chemical method and was shown to be a small nuclear RNA, U5. The transforming potential of the RNA was further studied in quantitative transformation assays using 3Y1, a rat fibroblastic cell line. Transformed foci appeared with a latency of 3 to 4 weeks after transfection. U5-transformed 3Y1 cells frequently carried an amplified c-myc oncogene. In addition, U5 induced chromosome aberratio

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6

Hamada, K., T. Kumazaki, K. Mizuno, and K. Yokoro. "A small nuclear RNA, U5, can transform cells in vitro." Molecular and Cellular Biology 9, no. 10 (1989): 4345–56. http://dx.doi.org/10.1128/mcb.9.10.4345-4356.1989.

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Low-molecular-weight RNA exhibiting transforming potential was identified in chemically induced lymphoma cells by the transformation of mink lung cells after transfection. The RNA was sequenced by the direct chemical method and was shown to be a small nuclear RNA, U5. The transforming potential of the RNA was further studied in quantitative transformation assays using 3Y1, a rat fibroblastic cell line. Transformed foci appeared with a latency of 3 to 4 weeks after transfection. U5-transformed 3Y1 cells frequently carried an amplified c-myc oncogene. In addition, U5 induced chromosome aberratio

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7

Dokal, I., J. Bungey, P. Williamson, D. Oscier, J. Hows, and L. Luzzatto. "Dyskeratosis congenita fibroblasts are abnormal and have unbalanced chromosomal rearrangements." Blood 80, no. 12 (1992): 3090–96. http://dx.doi.org/10.1182/blood.v80.12.3090.3090.

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Abstract Dyskeratosis congenita (DC) is a rare inherited disorder characterized by bone marrow failure, dystrophic changes in the skin and mucous membranes, and a predisposition to malignancy. The DC locus has been mapped to Xq28. The primary defect responsible for this disease remains unknown. We have studied four patients with this disease, three from one family and one from another. In all four patients, primary skin fibroblast cultures were abnormal both in morphology (polygonal cell shape, ballooning, and dendritic-like projections) and in growth rate (doubling time about twice normal). F

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8

Mohanvel, Sucharitha Kannappan, Satish Kumar Rajasekharan, Trishna Kandhari, Balaji Prasanna Kumar Gopal Doss, and Yuvarani Thambidurai. "COW URINE DISTILLATE AS A BIOENHANCER FOR ANTIMICROBIAL & ANTIPROLIFERATIVE ACTIVITY AND REDISTILLED COW URINE DISTILLATE AS AN ANTICLASTOGEN AGENT." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 273. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.18879.

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Objective: The objective of this study was to prove that cow urine distillate (CUD) is a bioenhancer for antimicrobial activity and antiproliferative activity, redistilled CUD (RCUD) as an anticlastogen agent.Methods: The antimicrobial activity of rifampicin with CUD at different concentrations was determined against pathogenic Escherichia coli by well puncture method. The Penicillin and ciprofloxacin in combination with CUD at different/increasing concentrations against pathogenic E. coli culture were also determined by disc diffusion method. Sulforaphane (ACA) as an anticancer agent was extr

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9

van Beerendonk, G. J. M., S. D. Nelson, and J. H. N. Meerman. "Metabolism and Genotoxicity of the Halogenated Alkyl Compound Tris(2,3-Dibromopropyl)phosphate." Human & Experimental Toxicology 13, no. 12 (1994): 861–65. http://dx.doi.org/10.1177/096032719401301208.

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1 The genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) was studied in vivo. Results showed that Tris-BP was highly clasfogenic, but it could only initiate a low number of preneoplastic foci in the rat liver in vivo. In Drosophila, Tris-BP could be classified as a cross-linking agent, because it was more clastogenic than mutagenic. The use of completely deuterated Tris-BP as a metabolic probe revealed that cytochrome P450 and most likely the formation of 2-bromoacrolein (2BA) from Tris-BP is important for the observed genotoxic effects. 2 In contrast to the high mu

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10

Huang, ZH, N. Li, KF Rao, et al. "Development of a data-processing method based on Bayesian k-means clustering to discriminate aneugens and clastogens in a high-content micronucleus assay." Human & Experimental Toxicology 37, no. 3 (2017): 285–94. http://dx.doi.org/10.1177/0960327117695635.

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Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN size, intensity, or morphology, which yields low accuracies (70–84%) because each of these parameters may contribute to the results. Therefore, the development of an algorithm that can synthesize high-dimensionality data to attain comparative results is important. To improve the automation and accuracy of detection using the current parameter-based mode of act

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