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1
Zarrillo, James. "Beverly Cleary, Ramona Quimby, and the Teaching of Reading." Children's Literature Association Quarterly 13, no. 3 (1988): 131–35. http://dx.doi.org/10.1353/chq.0.0067.
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Pecina, Jozef. "Literature as a Political Tool: Whig Efforts to Prevent the Election of Martin Van Buren." CLEaR 4, no. 2 (September 1, 2017): 1–6. http://dx.doi.org/10.1515/clear-2017-0006.
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Abstract Starting with Andrew Jackson, presidential candidates in the United States used campaign biographies as useful political tools, and since 1824 no presidential election year has passed without a campaign biography. Martin Van Buren, President Jackson’s successor in the White House, became a target of a vicious campaign intended to prevent his election. His Whig opponents used a number of literary genres to slander him, including a mock campaign biography and a novel. The article focuses on the portrayal of Martin Van Buren in The Life of Martin Van Buren, allegedly written by Davy Crockett in 1835, and a novel named The Partisan Leader; A Tale of the Future, written by Nathaniel Beverley Tucker in 1836. Though being of different genres, these curious and obscure works have certain things in common - they were written under pseudonyms, their main goal was to prevent the election of Martin Van Buren and both of them failed in their goal.
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Tharchin, Tsultrim, Elango Balu, and Sherjang Singh. "Yield Enhancement due to Addition of Bevel Cleans at Middle of Line(MOL) Zone." Solid State Phenomena 282 (August 2018): 329–33. http://dx.doi.org/10.4028/www.scientific.net/ssp.282.329.
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As the technology nodes become smaller and smaller the circuit dies get closer and closer to the edge of the wafer. Defects and issues on the bevel are seen to cause issues such as flaking and blocked plating on the dies at the edge of the wafer. This drastically increases the need for a clean wafer edge as the issues directly translate to yield loss at the end of the line. The wafer edge and backside are shown to have a significant impact on yield as well as process variation [1]. Introducing a dilute HF and SC1 bevel clean at the MOL layer resolves flaking and defect issues found on the bevel. Dispensing it on the backside of the wafer and ensuring that the chemistry is rolled over to the bevel results in the backside of the wafer becoming cleaner and helps resolve overlay issues. All the above stated effects are seen to result in an overall edge gain in edge yield.
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Kaup, Soujanya, Siddharudha Shivalli, Chinnappa Ajjinicanda Ganapathi, Cynthia Arunachalam, John Buchan, Suresh Kumar Pandey, and Krishna Prasad Kudlu. "Does the phaco TIp position during clear corneal Phacoemulsification Surgery adversely affect corneal endothelium? TIPS study protocol for a randomised, triple-masked, parallel-group trial of bevel-up versus bevel-down phacoemulsification." Wellcome Open Research 5 (July 16, 2020): 167. http://dx.doi.org/10.12688/wellcomeopenres.16098.1.
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Introduction: Globally, at least 30 million cataract surgeries are required annually to prevent cataract-related blindness. Corneal endothelial decompensation is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The increasing ageing population and reduced visual impairment threshold for cataract surgery have resulted in rising cataract surgical rates and hence, an increase in corneal endothelial decompensation is expected. The role of phaco tip position on corneal endothelial damage is ambiguous. Previous studies have reported contradictory results and were also underpowered to detect a significant difference due to small sample sizes. With no consensus regarding the most cornea-friendly phaco tip position (bevel-up versus bevel-down) during phacoemulsification, we propose a randomised clinical trial with a robust design using direct chop phaco-technique. Objective: To compare the effect of phaco tip position (bevel-up vs. bevel-down) on corneal endothelial cell count during phacoemulsification. Methods: A randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio is proposed. By adopting stratified randomisation (according to cataract grade), we will randomly allocate 480 patients aged >18 years with immature cataract into bevel-up and bevel-down groups at two centres. History of significant ocular trauma, previous intraocular surgery, shallow anterior chamber, low endothelial cell count, pseudoexfoliation syndrome, intraocular inflammation, and corneal endothelial dystrophy are the key exclusion criteria. The primary outcome is postoperative endothelial cell count at one month. Secondary outcomes are central corneal thickness on postoperative days 1, 15, and 30, and intraoperative complications. Trial registration: Clinical Trial Registry of India CTRI/2019/02/017464 (05/02/2019).
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Kaup, Soujanya, Siddharudha Shivalli, Chinnappa Ajjinicanda Ganapathi, Cynthia Arunachalam, John Buchan, Suresh Kumar Pandey, and Krishna Prasad Kudlu. "Does the phaco TIp position during clear corneal Phacoemulsification Surgery adversely affect corneal endothelium? TIPS study protocol for a randomised, triple-masked, parallel-group trial of bevel-up versus bevel-down phacoemulsification." Wellcome Open Research 5 (January 25, 2023): 167. http://dx.doi.org/10.12688/wellcomeopenres.16098.2.
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Introduction: Globally, at least 30 million cataract surgeries are required annually to prevent cataract-related blindness. Corneal endothelial decompensation is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The increasing ageing population and reduced visual impairment threshold for cataract surgery have resulted in rising cataract surgical rates and hence, an increase in corneal endothelial decompensation is expected. The role of phaco tip position on corneal endothelial damage is ambiguous. Previous studies have reported contradictory results and were also underpowered to detect a significant difference due to small sample sizes. With no consensus regarding the most cornea-friendly phaco tip position (bevel-up versus bevel-down) during phacoemulsification, we propose a randomised clinical trial with a robust design using direct chop phaco-technique. Objective: To compare the effect of phaco tip position (bevel-up vs. bevel-down) on corneal endothelial cell count during phacoemulsification. Methods: A randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio is proposed. By adopting stratified randomisation (according to cataract grade), we will randomly allocate 480 patients aged >18 years with immature cataract into bevel-up and bevel-down groups at two centres. History of significant ocular trauma, previous intraocular surgery, shallow anterior chamber, low endothelial cell count, pseudoexfoliation syndrome, intraocular inflammation, and corneal endothelial dystrophy are the key exclusion criteria. The primary outcome is postoperative endothelial cell count at one month. Secondary outcomes are central corneal thickness on postoperative days 1, 15, and 30, and intraoperative complications. Trial registration: Clinical Trial Registry of India CTRI/2019/02/017464 (05/02/2019).
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Park, Jin-Ho, and Lionel March. "The Shampay House of 1919: Authorship and Ownership." Journal of the Society of Architectural Historians 61, no. 4 (December 1, 2002): 470–79. http://dx.doi.org/10.2307/991869.
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The Shampay House of 1919 has been commonly understood to be the very last of Frank Lloyd Wright's cruciform Prairie houses. It was planned to be erected in Beverly Hills, Illinois, but the client withdrew amid legal acrimony at the design stage. In this period, when Wright was frequently in Tokyo working on the Imperial Hotel and other commissions in Japan, Rudolph M. Schindler was left in charge of Wright's offices in the United States. While the Shampay House clearly comes out of Frank Lloyd Wright's studio, so that ownership of the design is not in question, this paper traces the controversy-between the two architects themselves as well as subsequent commentators-concerning the authorship of the project. The evidence presented unambiguously determines who conceived the design, the degree of Wright's involvement in its development, and the original contributions that Schindler brought to it. Previously unknown and unpublished blueprints and extracts from correspondence between Wright and Schindler are used extensively in the discussion.
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Lin, Yi-Chun, Yi-Ting Cheng, Tian Zhou, Radhika Ravi, Seyyed Hasheminasab, John Flatt, Cary Troy, and Ayman Habib. "Evaluation of UAV LiDAR for Mapping Coastal Environments." Remote Sensing 11, no. 24 (December 4, 2019): 2893. http://dx.doi.org/10.3390/rs11242893.
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Unmanned Aerial Vehicle (UAV)-based remote sensing techniques have demonstrated great potential for monitoring rapid shoreline changes. With image-based approaches utilizing Structure from Motion (SfM), high-resolution Digital Surface Models (DSM), and orthophotos can be generated efficiently using UAV imagery. However, image-based mapping yields relatively poor results in low textured areas as compared to those from LiDAR. This study demonstrates the applicability of UAV LiDAR for mapping coastal environments. A custom-built UAV-based mobile mapping system is used to simultaneously collect LiDAR and imagery data. The quality of LiDAR, as well as image-based point clouds, are investigated and compared over different geomorphic environments in terms of their point density, relative and absolute accuracy, and area coverage. The results suggest that both UAV LiDAR and image-based techniques provide high-resolution and high-quality topographic data, and the point clouds generated by both techniques are compatible within a 5 to 10 cm range. UAV LiDAR has a clear advantage in terms of large and uniform ground coverage over different geomorphic environments, higher point density, and ability to penetrate through vegetation to capture points below the canopy. Furthermore, UAV LiDAR-based data acquisitions are assessed for their applicability in monitoring shoreline changes over two actively eroding sandy beaches along southern Lake Michigan, Dune Acres, and Beverly Shores, through repeated field surveys. The results indicate a considerable volume loss and ridge point retreat over an extended period of one year (May 2018 to May 2019) as well as a short storm-induced period of one month (November 2018 to December 2018). The foredune ridge recession ranges from 0 m to 9 m. The average volume loss at Dune Acres is 18.2 cubic meters per meter and 12.2 cubic meters per meter within the one-year period and storm-induced period, respectively, highlighting the importance of episodic events in coastline changes. The average volume loss at Beverly Shores is 2.8 cubic meters per meter and 2.6 cubic meters per meter within the survey period and storm-induced period, respectively.
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Titiyal, Jeewan S., Manpreet Kaur, Farin Shaikh, and Aafreen Bari. "‘Acute-angled bevel’ sign to assess donor lenticule orientation in ultra-thin descemet stripping automated endothelial keratoplasty." BMJ Case Reports 12, no. 2 (February 2019): e227927. http://dx.doi.org/10.1136/bcr-2018-227927.
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A 6.5-year-old boy with congenital hereditary endothelial dystrophy underwent clear corneal ultra-thin descemet stripping automated endothelial keratoplasty (DSAEK). After graft insertion, it was difficult to assess graft orientation due to hazy cornea. Intraoperative optical coherence tomography (iOCT) showed a well-attached graft and the bevelled edge of donor lenticule made an acute angle with the overlying stroma. Postoperative anterior segment OCT confirmed the presence of acute-angled bevel sign. A wetlab experiment was performed with experimental corneoscleral tissues to confirm the findings. Donor lenticule was injected in the artificial chamber with stromal-side up as well as stromal side-down. ‘Acute-angled bevel sign’ was observed on iOCT in the experimental cases with stromal-side up. In inverse graft, the acute-angled bevel was not observed, instead the configuration was obtuse angled. Identifying the ‘acute-angled bevel sign’ on iOCT confirms correct graft orientation after unfolding and is extremely useful for hazy corneas and ultrathin DSAEK lenticules.
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Lin, Chao, and Chunjiang He. "Tooth contact analysis of elliptical bevel gear with different misalignment." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 233, no. 7 (August 6, 2018): 2516–25. http://dx.doi.org/10.1177/0954406218791637.
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Considering the wide use of bevel gear, a new bevel gear type with variable transmission ratio has been proposed. Based on the manufacturing and generating theory of gear, the mathematical equations for the tooth surface of this gear type has been established with two different methods: lead crowning, which meets the commonly used industrial methods with higher efficiency, lower cost and the method with rack cutter shows much clear relationship of gear meshing process. The contact points and characteristics of transmission errors with different misalignment conditions have been presented. Also the feature of contact area on the tooth surface in a whole cycle was developed in this paper. Compared the contact results of elliptical bevel gear with curve face gear, the former has less misalignments sensitivity and better loaded capability.
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Hudon, Michèle, and Laure Amélie Guitard. "KO and classification instruction objectives: Are we keeping up with the transformation of our field?" NASKO 4, no. 1 (October 31, 2013): 112. http://dx.doi.org/10.7152/nasko.v4i1.14651.
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Each objective listed in courses entirely or partially dedicated to knowledgeorganization (KO) and bibliographic classification in 30 distinct LIS programs was categorized as to: 1. its nature; 2. its subject; 3. its focus; 4. its taxonomic level. The results tend to reinforce observations made over the past 30 years in relation to KO and classification courses. Teaching and learning objectives tend to bevery general, with a clearly dominant theoretical focus. Few objectives focus specifically on the complex process of analyzing subjects, and on new types of skills now required to work with classification structures available in digital form. And even if KO educators recognize the necessity for students to develop high-level analytic and evaluative skills, there are very few references to those skills in current course objectives.
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Takahara, Hikari, and Ken Tsugane. "Trace Metallic Contamination Analysis on Wafer Edge and Bevel by TXRF and VPD-TXRF." Solid State Phenomena 145-146 (January 2009): 105–8. http://dx.doi.org/10.4028/www.scientific.net/ssp.145-146.105.
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In the semiconductor industry, the edge exclusion of processed wafers is decreasing to accommodate more integrated circuits. With this trend, there is a higher risk of detrimental contamination at the wafer edge and bevel making the monitoring for metallic contamination in these areas critical. Cross contamination from the edge and bevel can occur at many processing steps. For example, metals can spread from the wafer edge, bevel and backside to the wafer’s surface in a wet cleans process. In immersion lithography, the water drop that is scanned across the wafer could transport contamination from the edge and deposit it across the wafer surface. Contamination on wafer edge and bevel can have many origins; handling systems in every process tool, reaction products in etching, and residuals of new materials in high-k for CVD and PVD, for example. To know what metallic contamination is present, and to investigate the causes are essential for wafer edge control.
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Kawasaki, Kazumasa, and Isamu Tsuji. "Cutting Performance in Machining of Large-Sized Spiral Bevel Gears Using Multi-Axis Control and Multi-Tasking Machine Tool." Applied Mechanics and Materials 595 (July 2014): 91–97. http://dx.doi.org/10.4028/www.scientific.net/amm.595.91.
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Large-sized spiral bevel gears are usually manufactured based on a cyclo-palloid system and have equi-depth teeth as well as a face hobbing system by a continuous cutting procedure using a special generator. It has been possible to machine the complicated shape because of the development of a multi-axis control and multi-tasking machine tool.The manufacturing method of the gears has been proposed using this development process. In this method, the spiral bevel gears are modeled based on a CAD system and are machined based on a CAM system. In this paper, the cutting performance in machining of the large-sized spiral bevel gears using the multi-axis control and multi-tasking machine toolis investigated. As a result, the relationship between the tool life of end mill and gear accuracy were made clear. The surface roughness and tool mark of the machined gears were compared with those using the special generator.
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Corin, Ellen. "Later Life. The Social Psychology of AgingV.W. Marshall (ed.) Beverley Hills, CA: Sage Publications." Canadian Journal on Aging / La Revue canadienne du vieillissement 6, no. 1 (1987): 78–84. http://dx.doi.org/10.1017/s0714980800015415.
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SUMMARYThis study represents a significant contribution to the theoretical development of the social psychology of aging. The authors favor an interpretative approach to aging while emphasizing the features of the structural context. The theoretical challenge outlined in the book revolves around maintaining an equilibrium between the two points of view and examining the mechanisms that link the macro and the micro levels of society.The introduction provides a clear overview of the theoretical questions which reflect the essence of this book. A group of articles examines the socio-historic and theoretic roots of the interpretative approach in the general development of human sciences theories as well as in the work of G.H. Mead and the pragmatic American trend. Another series of articles concentrates on the changes which have taken place in the modern western societies; the authors examine the impact created by this revolution on the relationship between the generations, on the life span and on the relationship between the aged and death. Other contributions are made at a more micro-social level. These focus on the support systems available to the elderly as well as the networks of friends. The last article underlines the importance of adopting a comparative approach for all theoretical development.
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AL-Qrimli, Haidar F., Karam S. Khalid, Ahmed M. Abdelrhman, Roaad K. Mohammed A, and Husam M. Hadi. "A Review on a Straight Bevel Gear Made from Composite." Journal of Materials Science Research 5, no. 3 (June 30, 2016): 73. http://dx.doi.org/10.5539/jmsr.v5n3p73.
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The purpose of this work is to present a clear fundamental thought for designing and investigating straight bevel gear made of composite material. Composite materials have the advantage of being light, producing low noises, and extra loading capacities. Due to these properties, it is highly preferable over conventional materials. A comparison between different types of material used in a gear structure will be shown. The outcome shows that a new form of cheap material may be useful for designing a new type of lighter and stiffer gear, designed for robotic arm applications or any power transmission application.
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Campbell, Petreena S., Erik D. Harris, Nancy Moore, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, Alice Chen, James H. Doroshow, and Annamaria Rapisarda. "Abstract 154: Establishment and characterization of a novel clear cell sarcoma organoid model derived from a human biopsy." Cancer Research 83, no. 7_Supplement (April 4, 2023): 154. http://dx.doi.org/10.1158/1538-7445.am2023-154.
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Abstract Clear Cell Sarcoma (CCS) is an extremely aggressive, rare soft tissue cancer accounting for approximately 1% of all sarcomas. Often diagnosed in young adults with a median age of 25 years, CCS has a strong propensity for local recurrence and metastasis with an overall high mortality rate. Current treatment recommendations include radical surgical extirpation, followed by radiation or chemotherapy. Nonetheless, there is a need for extensive postoperative follow-up as the efficiency of adjuvant therapy in managing this disease remains poor. Consequently, it is imperative to identify clinically relevant models to advance our understanding of CCS tumor biology and facilitate the development of novel therapies. Compared to conventional preclinical tumor models, patient-derived organoids (PDOrgs) better recapitulate the patient tumor biology, genetic heterogeneity, and therapeutic responses. Here, we describe the development and validation of a human biopsy-derived CCS organoid model 1010561-T. 1010561-T was established from a male patient's metastatic paraspinal mass. This PDOrg demonstrates a moderate growth rate (doubling time of ~20 days) and pleomorphic traits, consisting mainly of solid, grape-like clusters, as well as elongated cells of mixed morphology. Furthermore, this model was successfully maintained over 7 months in culture and remained stable more than one year after cryopreservation. 1010561-T exhibits the cytogenetic hallmark of CCS which is the presence of a recurrent t(12;22)(q13;q12) chromosomal translocation, resulting in a fusion between the Ewing sarcoma gene and activating transcription factor 1 (EWS/ATF1 fusion). Reverse-transcription polymerase chain reaction (RT-PCR) confirmed that 1010561-T harbors a dual EWS/ATF1 fusion, namely EWS exon 8 to ATF1 codon 65 fusion (type 1) and EWS exon 7 to ATF1 codon 110 fusion (type 3). Quantitative RT-PCR and immunocytochemistry revealed strong expression of melanocytic differentiation markers typical of CCS including melanocyte inducing transcription factor (MITF), melan-A (MLANA), premelanosome protein (PMEL), and S100 calcium binding protein A11 (S100A11). Additionally, the gene expression profile of 1010561-T is in concordance with a well-established CCS cell line, SU-CCS-1. To our knowledge, 1010561-T is the first human CCS organoid model. It is, therefore, a valuable resource for advancing our understanding of the biology of this very rare disease, in addition to being a useful tool for validating new preclinical therapies that are undoubtedly needed to achieve better clinical outcomes for patients. To this end, 1010561-T will be transferred to the National Cancer Institute’s Patient-Derived Models Repository (https://pdmr.cancer.gov) where it will be made available to the scientific community. This project was funded in part with federal funds from the NCI, NIH, under contract no. HHSN261201800001I. Citation Format: Petreena S. Campbell, Erik D. Harris, Nancy Moore, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, Alice Chen, James H. Doroshow, Annamaria Rapisarda. Establishment and characterization of a novel clear cell sarcoma organoid model derived from a human biopsy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 154.
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Jalalian, Ezzatollah, Hamed Jannati, and Maryam Mirzaei. "Evaluating the Effect of a Sloping Shoulder and a Shoulder Bevel on the Marginal Integrity of Porcelain-Fused-to-Metal (PFM) Veneer Crowns." Journal of Contemporary Dental Practice 9, no. 2 (2008): 17–24. http://dx.doi.org/10.5005/jcdp-9-2-17.
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Abstract Aim A porcelain-fused-to-metal (PFM) veneer crown restoration is considered successful when biological, mechanical, and esthetical concerns are satisfied. Restorations with poor marginal integrity may contribute to the cause of severe caries and periodontal defects. The most important factor in achieving successful marginal integrity is preparation design. Although a sloping shoulder preparation offers biologic and esthetic advantages over a shoulder bevel, a comparison of the marginal integrity of these two designs is less clear and is the main focus of this study. Methods and Materials This study was based on the analysis of 40 PFM veneer specimens fabricated on 20 stone dies. Each die had a beveled shoulder on one side of the preparation and a sloping shoulder design on the other. All specimens were selected and managed in an identical manner throughout the entire experimental process. All specimens were fabricated on stone dies made from a standard stainless steel die with the two shoulder designs in the preparation. Marginal integrity of the PFM veneers was evaluated using a scanning electron microscope to measure the gap between the restoration and tooth margin. The data were analyzed using the Student t-test at a significance level of p>0.05. Results An average amount of gap (± SD) for the test groups were as follows: shoulder bevel, 40.78±18.4 microns; sloping shoulder, 52.8±27.4 microns (p>0.05). All the data were within acceptable clinical range and no significant difference between two preparation designs were observed. Conclusions Within the limitations of this study the marginal integrity of both preparation designs were found to be similar. Since the sloping shoulder design offers biological and esthetical advantages over the shoulder bevel, its use is indicated for anterior restorations. Citation Jalalian E, Jannati H, Mirzaei M. Evaluating the Effect of a Sloping Shoulder and a Shoulder Bevel on the Marginal Integrity of Porcelain-Fused-to-Metal (PFM) Veneer Crowns. J Contemp Dent Pract 2008 February;(9)2:017-024.
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Wang, Pei-Yu, and Zhang-Hua Fong. "Fourth-Order Kinematic Synthesis for Face-Milling Spiral Bevel Gears With Modified Radial Motion (MRM) Correction." Journal of Mechanical Design 128, no. 2 (March 3, 2005): 457–67. http://dx.doi.org/10.1115/1.2168466.
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The use of a fourth-order motion curve is proposed by Stadtfeld and Gaiser to reduce the running noise of a bevel gear set recently. However, the methodology of synthesizing the tooth surfaces was not clearly shown in the literature. In this work, we proposed a methodology to synthesize the mating tooth surfaces of a face-milling spiral bevel gear set transmitting rotations with a predetermined fourth-order motion curve and contact path. A modified radial motion (MRM) correction in the machine plane of a computer numerical control (CNC) hypoid generator is introduced to modify the pinion tooth surface. With MRM correction, an arbitrary predetermined contact path on the pinion tooth surface with predetermined fourth-order motion curve can be achieved. Parameters of MRM correction are calculated according to the predetermined contact path and motion curve. As shown by the numerical examples, the contact path and the motion curve were obtained as expected by applying the MRM correction. The results of this work can be applied to the pinion, which is generated side-by-side (for example, fixed setting method, formate method, and Helixform method) and can be used as a basis for further study on the motion curve optimizations.
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Wang, Jia You, J. H. Yu, C. H. He, and F. Yang. "Effect of Arc Current Ultrasonic-Frequency Pulsation on Plasma Cut Quality." Materials Science Forum 628-629 (August 2009): 721–26. http://dx.doi.org/10.4028/www.scientific.net/msf.628-629.721.
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The present work proposes a novel plasma cutting system using the ultrasonic frequency pulsed arc, and then experimentally investigates the effect of pulse process parameters on cut quality in the frequencies of 20-60 kHz. It is shown that kerf widths, bevel angle, straightness and dross attached level decrease obviously with the appropriate increases in the frequency and amplitude of pulse current. Furthermore, cutting heat affected zone narrows and cut hardness drops clearly in the pulsed cutting. This current pulsation can thus improve plasma cut quality remarkably, and finally leads to a narrower, flatter and more perpendicular cut of better remachinability. Experimental results simultaneously demonstrate that the effectiveness of the ultrasonic-frequency pulsed cutting process developed at the low current of arc.
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von Arnim, Mareike, Stefan Eichler, Oliver Brätz, Jörg Hildebrand, Ulrike Kuhlmann, Jean Pierre Bergmann, and Wilko Flügge. "Study on load‐carrying capacity of MAG butt‐welded mixed connections with different steel strengths." ce/papers 6, no. 3-4 (September 2023): 1458–63. http://dx.doi.org/10.1002/cepa.2262.
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AbstractMixed connections of normal‐strength steel and high‐strength steel can enable an optimum resource‐saving use of materials by adapting the material strength to the forces acting on them. But the design and calculation of butt‐welded mixed connections is not clearly regulated in the currently valid standards EN 1993‐1‐8 and EN 1993‐1‐12. In the research project Effective design concepts for mixed connections in steel structures an extensive experimental program with 180 mixed connections has been conducted to investigate the load‐carrying capacity and behaviour of these connections. The weld joint specimens were made with normal‐strength steel S355J2+N and different high‐strength steels S690QL, S700MC or S960QL. Varying parameters were also the filler metals, plate thicknesses, weld bevels and the heat input during welding. The influence of these parameters on the load‐carrying capacity and the deformation behaviour of mixed connections was investigated. Moreover, high‐resolution microhardness mappings (UCI) on the welded specimens were carried out to examine the formation of the soft zone in the heat‐affected zone of the high‐strength steels.
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Cooney, Thomas F., H. Trey Skinner, and S. M. Angel. "Comparative Study of Some Fiber-Optic Remote Raman Probe Designs. Part I: Model for Liquids and Transparent Solids." Applied Spectroscopy 50, no. 7 (July 1996): 836–48. http://dx.doi.org/10.1366/0003702963905592.
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We have developed models describing the sensitivity and sampling volume of various remote fiber-optic Raman probes—single-fiber, lensed, dual-fiber beveled-tip, dual-fiber flat-tipped, and multi-fiber flat-tipped. The models assume clear samples and incorporate radii, separation, bevel angle, and numerical aperture of the fibers; overlap geometry of illumination and excitation light cones; and refractive index of immersion medium. For the Raman spectra of solid samples in air, single-fiber and lensed probes are predicted to yield the highest Raman signal. Beveled probes should provide greater Raman signal strength than do flat-tipped probes because beveled probes can collect light from a restricted volume closer to the probe end. Although multiple collection fibers improve Raman signal strength, progressively distant concentric fiber rings contribute less and sample material further from the probe.
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Schupp, James R., H. Edwin Winzeler, and Melanie A. Schupp. "Stub Length and Stub Angle Did Not Influence Renewal Shoot Number or Branch Angle of Tall Spindle ‘Gala’/Malling 9 Apple Trees." HortTechnology 29, no. 1 (February 2019): 46–49. http://dx.doi.org/10.21273/horttech04218-18.
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Renewal of limbs by pruning to leave a short, angled, upward-facing stub is common practice for spindle-type apple (Malus ×domestica) training systems. A short, beveled stub cut is thought to stimulate renewal growth from latent buds present underneath the base of the excised branch, and to stimulate smaller, more fruitful renewal limbs with wide crotch angles. We conducted trials over the course of 2 years that involved dormant pruning of ‘Buckeye Gala’ with renewal cuts to compare two stub lengths, 0.5 and 2 cm, and three stub orientations, upward facing, downward facing, and vertical facing, to determine the effects on renewal shoot number, position, angle, and length. We found no clear advantages with either stub length that we evaluated, and there was no improvement in renewal shoot quality with a bevel cut at any orientation. Stub length and stub angle did not influence limb renewal and may be unimportant for training orchard-pruning crews and for machine-learning and robotic pruning.
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Coates, Simon J. "The Bishop as Pastor and Solitary: Bede and the Spiritual Authority of the Monk-Bishop." Journal of Ecclesiastical History 47, no. 4 (October 1996): 601–19. http://dx.doi.org/10.1017/s0022046900014639.
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‘One is always aware of Bede's Church as an institution of men and women, meetings and buildings, and especially as a bishops' Church.’ With this comment, J. M. Wallace-Hadrill directed attention to a fundamental aspect of Bede's world which requires further examination. From early childhood until his death, Bede was and remained a monk. He had entered themonasteriumof Wearmouth and Jarrow at the age of seven and was to remain in it all his life. Although he was ordained to the priesthood by John of Beverley he never advanced to episcopal office. Despite the fact that he was nurtured in a world of reflective scholarship at Wearmouth and Jarrow it is now less common for historians to view Bede as ‘a lonely intellectual locked in an elite minority community’ and a scholar who lived out his life away from the events of the outside world. He perceived that world and the clergy who occupied it, however, through monastic eyes. Since Bede is, and indeed should be, seen as a representative and guardian of a monastic culture heavily influenced by Benedictine spirituality his views concerning the episcopate have not been analysed to the same extent as his views concerning monasticism. This is somewhat surprising since Bede himself perceived a clear link between the episcopal and monastic lives and was deeply concerned with the early Anglo-Saxon Church as an episcopally governed institution. The purpose of this article is to examine Bede's exploration of the manner in which individual bishops came personally to define their prestige, power and authority. This involves an investigation of their continued attachment to ascetic traditions once they had been elevated to the episcopate and an examination of the models applying ascetic sanctity to an episcopal context which Bede inherited from his predecessors in the late antique and early Christian world.
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Verelst, P., M. Verstraeten, N. Tulkens, and T. Maertens. "Preoperative assessment of expectations, anxiety and preferences for anesthesia in patients undergoing ambulatory knee arthroscopic surgery." Acta Anaesthesiologica Belgica 71, no. 4 (December 2020): 177–81. http://dx.doi.org/10.56126/71.4.3.
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Objective : In this observational study, we aimed at measuring preoperative anxiety and preferences for anesthesia in patients undergoing knee arthroscopic surgery. Background : Little is known about preoperative anxieties, expectations and preferences of patients undergoing surgery, for which both spinal or general anesthesia can be provided. Literature shows that spinal anesthesia is associated with lower postoperative co- morbidity and mortality rates as compared to general anesthesia (1-2). Anxiety itself is an important factor influencing patients’ outcome (3). Methods : Every patients >18 years old undergoing an ambulatory arthroscopy of the knee in the surgical day care center of the AZ Nikolaas (in Sint-Niklaas and Beveren), was asked preoperatively to fill in a questionnaire. The questionnaire focused both on the patients’ knowledge about and preference of anesthesia, as well as their preoperative anxieties and worries. Patients were asked to score preoperative anxiety on a 5-point anxiety scale for any of 9 aspects/complications of the anesthetic (placement of the IV cannula, spinal puncture, death, awareness, pain, postoperative nausea and vomiting, cognitive impairment, infection, blood loss). During the study period, from January 11/01/ 2019 to 11/06/2019, a total of 806 patients were asked to fill out the questionnaire. 201 of these patients completed the questionnaire and were consequently enrolled in the study. This work has been approved by the Ethics Committee of the AZ Nikolaas on 11/11/2018 and by the Ethics Committee of the University Hospital in Antwerp (UZA) on 19/11/ 2018. Results : Seventy-five % of patients had a clear preference for their anesthesia technique. Of these, 2/3 opted for general anesthesia. Patients mainly based their preference on a subjective feeling ; a minority had discussed the choice with their surgeon or general practitioner. Rarely, patients indicated the wish to talk to the anesthesiologist about their choice. Fear for a spinal puncture occurred in 40% of patients (median anxiety score 3/5, range 1-5) and was therefore the most prominent anxiety in this patient population. Conclusions : Patients’ greater preference for general over spinal anesthesia was clearly based rather on a subjective than an objective basis. Forty 40% of patients had a substantial fear for spinal puncture. By informing patients about the risks and complications of the different anesthesia techniques, anxiety feelings can probably be alleviated, and a well-judged decision about their anesthesia technique can be made. There is room for improvement in communication and discussion between patients and anesthesiologists about the patients’ choice of anesthesia technique.
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Putri, Gusti Ayu. "Photovoice Implementation in Teaching English Guiding at English Study Program College of Foreign Language (STIBA) Saraswati Denpasar." English Focus: Journal of English Language Education 1, no. 2 (July 2, 2018): 86–95. http://dx.doi.org/10.24905/efj.v1i2.35.
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Guiding is a branch of oral communication. In oral communication, guiding can be included as productive skill. English guiding is one of the academic lessons in the fourth semester. Being a tour guide is a very important job in tourism part. In many cases, the tour guide is a traveller's first impression of a foreign country. In other cases a tour guide may be responsible for teaching tourists about the culture and sites in a city or town. Improving students’ communicative skill is the goal of teaching English guiding, because the student can express themselves and know how to use language well. In the real situation in teaching guide process, lecturer cannot escape from reality. It occurs because there are some problems faced by the lecture and the student. The lecturer cannot make student pay attention; make the students’ lack of creativity in making interactive guiding topics, and engagement in whole teaching learning process.
This research applied photovoice as a technique to increase the student’s ability in speaking English guiding. Photovoice is suitable technique in teaching speaking skill in English guiding because it gives student chance to communicate with different context and different social by photo as a learning media. This reviews were taken from Beverly Palibroda (2009) Photovoice implementation and Speaking Assessment from Brown Lavinson (2004). This research was conducted by three cycles such as: pre-test, cycle I and cycle II. In composing this research the writer used qualitative descriptive method by classroom action research (CAR).
The result of this research showed that the mean score in pre-test before implementing Photovoice clearly showed that the ability of the subject under study was relatively “ fairly satisfactory ” in the level of mastery of speaking rubric. There were increasing in cycle I after implementing Photovoice technique. The result of the data analysis of the reflection score in cycle I showed increasing the mean score of 7.11 It was higher than the result of pre-test. In the cycle II, which the treatment was more intensive in order of weakness of the students had been known. The result of the data anaysis of reflection or post-test in cycle II that the mean score was 8.18. The different between mean score in cycle I and II was 1.07. It showed that the student’s speaking guiding ability improved after the researcher applied the photovoice thecnique to the students.
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de Graaf, S. P., L. Gillan, G. Evans, W. M. C. Maxwell, and J. K. O¿Brien. "330THE EFFECT OF SHEATH FLUID ON THE QUALITY OF SEX-SORTED RAM SPERMATOZOA." Reproduction, Fertility and Development 16, no. 2 (2004): 284. http://dx.doi.org/10.1071/rdv16n1ab330.
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The fertility of sexed frozen-thawed ram spermatozoa at low AI doses remains below commercially acceptable levels (Maxwell WMC et al. 2003 Theriogenology 59, 511 abst). The aim of the present study was to determine if the use of an artificial seminal plasma sheath fluid could attenuate the stress of dilution during flow cytometry and thus improve the functional capacity of sexed ram spermatozoa. Semen was collected from 3 Merino rams, processed for sex-sorting (Hollinshead FK et al. 2002 Reprod. Fertil. Dev. 14, 503–508), and then allocated to 2 treatment groups according to the sheath fluid used within the flow cytometer: (i) a tris-citrate-fructose diluent (TRIS), or (ii) an artificial seminal plasma diluent (ASP) (ODonnell JM 1969 J. Reprod. Fert. 19, 207–209). Spermatozoa were sorted using a modified high speed cell sorter (SX MoFlo®, DakoCytomation, Fort Collins, USA) without separation of X and Y bearing gametes, and then frozen and thawed using established protocols (Hollinshead FK et al. 2002). Motility characteristics (HTM-IVOS; Hamilton-Thorne, Beverly, USA) and acrosome integrity (FITC-PNA) were assessed throughout. Statistical analyses were conducted by ANOVA. Results indicate that in all but one instance (VSL pre-freeze), TRIS spermatozoa exhibited higher (P<0.05) total motility (TM), average path velocity (VAP), straight line velocity (VSL), curvilinear velocity (VCL) and amplitude of lateral head displacement (ALH) compared to ASP spermatozoa (Table 1). Conversely, ASP treatments displayed enhanced straightness (STR) and linearity (LIN) pre-freezing and immediately post-thaw. In addition, the percentage of hyperactivated (HA) spermatozoa prior to freezing (± SEM) was lower (P<0.05) for ASP (3±1.1) than for TRIS (20±3.4), although post-thaw the differences were NS. Acrosome integrity remained similar (P>0.05) among treatments before and after thawing (range: 92.3–95.9% intact). In conclusion, the ASP sheath fluid resulted in decreased TM, velocity and ALH of sex-sorted frozen-thawed ram spermatozoa, a clear indication of the superiority of TRIS sheath fluid. The partial improvement in STR, LIN and HA that the ASP affords sex-sorted ram spermatozoa does not offset the aforementioned negatives, suggesting ASP is unsatisfactory for use as a sheath fluid during sperm sorting. Research supported by XY, Inc. Table 1 The effect of sheath fluid on motility characteristics (±SEM)
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Cooney, Thomas F., H. Trey Skinner, and S. M. Angel. "Comparative Study of Some Fiber-Optic Remote Raman Probe Designs. Part II: Tests of Single-Fiber, Lensed, and Flat- and Bevel-Tip Multi-Fiber Probes." Applied Spectroscopy 50, no. 7 (July 1996): 849–60. http://dx.doi.org/10.1366/0003702963905574.
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We compare relative performances of flat-tipped, beveled (two-fiber and six-around-one), and single-lensed focused fiber-optic Raman probes and, where feasible, evaluate the utility of optical filters for reducing fiber background. The sensitivity profile of each probe is determined by measuring the relative intensity of light backscattered off a flat surface as a function of distance from the probe tip. The experimental results are compared with a simple light-cone-overlap model incorporating fiber numerical aperture, fiber and immersion medium refractive indices, separation between excitation and collection fibers, number of fibers, and fiber bevel angle and/or lens focal length. The model and sensitivity profiles are used to interpret the sampling regions for Raman spectra obtained by using each of the probes with a clear, transparent sample (single-crystal sparry calcite), a white, partially transparent sample (acetaminophen tablet), and a set of organic liquids of varying refractive index. The sensitivity of the tested commercial lensed probe drops off symmetrically about the focal point. For both solid samples, the intensity of fiber background follows a profile determined primarily by laser backscattering off the surface, whereas the sample Raman signal follows a profile dependent upon sampling depth.
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Lee, Chang-keun, and Hoon-joo Kim. "Development of a STEP-based Production Information System for Block Assembly Process." Journal of Ship Production 23, no. 01 (February 1, 2007): 1–6. http://dx.doi.org/10.5957/jsp.2007.23.1.1.
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More effective production planning and scheduling in shipbuilding is needed to prepare the master data related to the products, the progress of work, and the production method. Therefore, it is most important to generate automatically the master data from a computer-aided design (CAD) model. However, production engineers manually read and analyze the assembly drawings with the detailed process of production, create, and input the master data. It is a time consuming job and also the data are neither clear nor accurate. In this study, we have developed a production information system using Standard for the Exchange of Product Model Data (STEP), which generates detailed production-oriented master data systematically and automatically from the CAD hull models considering work process. This production information includes many properties, such as assembly trees, working location, the working posture of setting and welding, material, detailed welding property, direction of stiffeners, plates and assemblies, specifications of parts and assemblies, curvature, turn-over, bevel of seams, slit and open, and throat thickness of welds. Secondly, three-dimensional geometric data (Virtual Reality Modeling Language, VRML) from subassemblies to grand assembly can be generated automatically according to the production process and method. We've tried to improve the quality of the production planning and scheduling with highly accurate detailed master data.
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Wang, Shuai, Ji He Zhou, and Chong Jia. "Kinematics Analysis on the Throwing Skills of Elite Chinese Male Hammer Athletes." Advanced Materials Research 950 (June 2014): 91–92. http://dx.doi.org/10.4028/www.scientific.net/amr.950.91.
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Hammer throw is one of the traditional track and field events but it only has a short history in China. Chinese hammer athlete Shizhu Wang won the championship of China Long Throw Open in 2013, but the performance in the game has a big gap with the world record. In order to improve the techniques of Chinese men hammer athletes, have a clearly understanding of the rational factors and internal relations of hammer throw technique, enrich the theory of the action and provide reference to the hammer throw training, we made a 3D camera resolution on the top three men hammer throwers (Shizhu Wang, Dakai Qi and Xiwan Jiang) at the game site of China Long Throw Open in 2013, with the three-dimensional analysis we gained the kinematic parameters. We made a comparison on the parameters between Chinese and foreign elite men hammer throwers. The result shows that: Compared with the datas of outstanding foreign athletes, the pre-swing time is much larger and hammer velocity increment is much smaller in the pre-swing stage; the total rotation time is much longer, and the single to double supporting time is distributed unreasonly, what’s more, the change between the knee joint and bevel angle are too small; the shot speed ,with the fastest Shizhu Wang of 24.87 m/s, is much slower than that of foreign famous athlete Sedych (30.7 m /s), and longer hammer throw running time, which are the main reasons that affect athletes’ performance.
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Zabrodskyi, Pavlo, Bohdan Sheludchenko, and Savelіі Kukharets. "Investigation of the influence of the method of fixing the cut-off tool inserts on its stress state." Scientific Horizons 24, no. 1 (April 14, 2021): 7–13. http://dx.doi.org/10.48077/scihor.24(1).2021.7-13.
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Cut-off tools equipped with carbide inserts are commonly used in turning operations. Due to the very heavy conditions in which such blades work, they fail, as a rule, not as a result of their operation, but due to the breakage of carbide inserts. This study investigates the causes of such failures and methods to prevent such phenomena. A thorough analysis of the current state and research methods of stress state in cutting tools, including turning cutters, was carried out. Methods of stress reduction in carbide inserts were also analysed. This paper focuses on the study of the stress state in cut-off tools with brazed carbide inserts. The stress state in the carbide inserts and the influence of different fixation methods of carbide insert to the holder were considered. The main approach to stress studies was the photoelasticity method, which allows quickly and clearly obtaining and evaluating the results. Models of carbide inserts were made of optically sensitive material. It as a part of a complex model of a cut-off tool with a carbide insert with three different methods of fixation were loaded with a force by means of a specially designed stand simulating the cutting force. The study was carried out on a PPU-7 polarisation-projection unit. Isochromatic and isocline patterns were obtained. The estimation of the principal stresses was performed by the difference of shearing stresses for three cross sections of the insert: at the surface, in the middle and at the base. It was found that the best result is given by the method in which the insert on the side far from the cutting edge has a bevel made at an angle of 10°
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Menapace, Rupert. "Mini- and Micro-incision Cataract Surgery – A Critical Review of Current Technologies." European Ophthalmic Review 03, no. 02 (2009): 52. http://dx.doi.org/10.17925/eor.2009.03.02.52.
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Modern cataract surgery is striving for smaller and smaller incisions with the aim of making clear corneal incisions that are as safe and topographically stable as possible. Recent innovations in both phacoemulsification (phaco) and intraocular lens (IOL) technology have made micro-incision cataract surgery, defined as <2mm incision, safe and effective. Bi-axial sleeveless micro-phaco has recently been joined by sleeve-armed micro-co-axial micro-phaco, made possible by the development of slim-shaft strong-bevel phaco needles armed with micro-sleeves that run flush with an enlarged needle head. Such tip technology allows for a highly efficient and safe high-flow, high-vacuum phaco through incisions as small as 1.4mm by providing high influx and suppressing surge while avoiding mechanical and thermal tissue damage. Two tips have so far been made available for mini- (2.2–2.4mm) and micro-incision cataract surgery (MICS) (1.4–1.6mm, depending on the incision architecture used). With the micro-tip supplemented by additional flow through an infusion spatula (‘infusion-assisted’ or ‘hybrid’ phaco), excessive flow and vacuum rates may be used, resulting in a two-fold efficiency as mirrored by the reduced phaco power required. IOL technology is lagging behind phaco technology. The challenge is to avoid trade-offs with regard to implant stability and aftercataract formation, as well as optical performance. Current MICS-IOLs are mostly hydrophilic acrylic one-piece constructions with insufficiently sharp posterior optic edges and broad haptic–optic junctions, both of which features compromise the optic-edge barrier effect. Recently, a hydrophobic three-piece IOL has been made available, which features a slim haptic junction and an exquisitely sharp optic edge and also allows for optional optic entrapment into a posterior capsulorhexis for lasting eradication of after-cataracts.
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AREMU, Nuha Salihu, Oluseyi Adetunji SHADARE, and Jimoh Rafiu AMOSA. "Talent Attraction And Organizational Competitiveness in Manufacturing Companies in Lagos, Nigeria." Journal of Human Resource Management - HR Advances and Developments 2023, no. 2 (December 11, 2023): 76–90. http://dx.doi.org/10.46287/emyj1495.
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Purpose- The main focus of the study is to examine how talent attraction dimensions such as employee value proposition, employer branding, Job flexibility and recruitment and selection affect organizational competitive-ness in manufacturing firms in Lagos State, Nigeria. Methodology- The study adopted a survey-based research design. The per-manent staff of the selected ten (10) food, beverages, and tobacco manufactur-ing firms in Lagos State made up the population of the study. The respond-ents consist of 368 employees which represent the sample size of the study. Data was obtained through the use of questionnaire. Relative Important In-dex (RII) and Multivariate linear regression was used for data analysis with aid of SPSS version 26. Findings- The result revealed a strong effect of talent attraction variables such as employee value proposition with (β=0.611, t= 7.451, p<0.05); Job flexibility with (β=0.505, t=9.182, p< 0.05); employer branding with (β=0.434, t= 9.607, p <.0.05) and recruitment and selection with (β=0.401, t=6.481, p <.0.05) on or-ganizational competitiveness. Limitations of the study-The scope of this study was limited to food, bever-ages and tobacco manufacturing subsector operating only within the territory of Lagos state, Nigeria. Furthermore, the study looked at talent attraction variables which is only a component of talent management strategies. Practical Implication-The manufacturing companies, especially the ones in food, beverages and tobacco manufacturing sub-sector should consider talent attraction strategies as a viable tool for identifying and attracting skilful and competent staff to fill vacant position. This is critical to the attainment of present and future organizational objectives as well as gaining competitive advantage. Originality/Value- This study makes a clear understanding of talent attrac-tion and its immense contribution to organizational competitiveness and performance. It also provided a basis for future researcher to explore more on the dynamics of talent attraction in the field of human resource management.
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Lloyd, Maxwell R., Lianne Ryan, Arielle J. Medford, Jennifer C. Keenan, Laura M. Spring, Neelima Vidula, Beverly Moy, et al. "Abstract P1-13-07: Investigating NF1 Mutations in Circulating Tumor DNA of Patients with Hormone-receptor Positive (HR+) Breast Tumors Resistant to CDK4/6 Inhibition (CDK4/6i): A Retrospective Clinical Analysis." Cancer Research 83, no. 5_Supplement (March 1, 2023): P1–13–07—P1–13–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p1-13-07.
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Abstract Background: CDK4/6 inhibitors (CDK4/6i) are standard of care for the management of HR+/HER2- metastatic breast cancer (MBC). Genomic alterations that drive resistance to CDK4/6i are diverse, and while the molecular landscape is heterogeneous, several mechanisms of CDK4/6i resistance converge on the RAS/MAPK and PI3K/AKT/mTOR signaling pathways. NF1 downregulates RAS and dampens cellular proliferation. Laboratory-based models demonstrate that loss of NF1 is associated with resistance to endocrine therapy (ET), and emergence of NF1 mutations (NF1m) are correlated with progressive disease (PD) in circulating tumor DNA (ctDNA). While NF1m may diminish CDK4/6i susceptibility, a clear relationship has not been elucidated. The primary objective of this study was to characterize patient (pt) response to CDK4/6i in NF1m HR+/HER2- MBC. Methods: We identified 47 pts with NF1m via a database with one or more ctDNA samples sequenced at variable time-points as part of routine care for MBC. NF1m were categorized as pathogenic (p)NF1m or variants of uncertain significance (VUS) based on their associated Guardant report. We identified 27 pts with HR+/HER2- MBC and NF1m that received at least 1 line of CDK4/6i in the metastatic setting. Intrinsic resistance was defined as PD < 6 months on a CDK4/6i regimen, and acquired resistance was defined as PD >6 months. Pts with intrinsic resistance or acquired resistance and NF1m detected post-PD were categorized as having a resistance phenotype potentially driven by NF1m. Pts with NF1m detected prior to therapy and >6 months clinical response on a CDK4/6i were categorized as having NF1m tumors sensitive to CDK4/6i. Results: The NF1m cohort (n = 27) had 9 pts with pNF1m, while 18 pts expressed VUS. The median age at MBC diagnosis was 54 years, and 67% had visceral metastasis at ctDNA collection. Pts received a median of 1 prior line (range: 0 - 6) of ET or chemotherapy in the metastatic setting before CDK4/6i. Amongst pts with pathogenic variants (n = 9), we found 3 pts with pNF1m were intrinsically resistant to CDK4/6i. Acquired resistance was seen in 1 pt with pNF1m detected post-PD, and 2 pts had evidence of both acquired and subsequent intrinsic resistance to a later line of CDK4/6i. Overall, 67% (6/9) of pNF1m pts demonstrated a CDK4/6i resistance phenotype; mutant allele fraction (AF) ranged from 0.2% - 29.9%, and the mean maximum allele fraction (MAF) was 6.0%. Pre- and post-treatment samples were available on 3 pts with pNF1m, and 1 of these pts had an AF rise from 2.7% to 12.3% when comparing ctDNA pre- and post-CDK4/6i. ctDNA from 4 of 6 resistant tumors harbored other putative drivers including alterations in FGFR, KRAS, PTEN, and RB. We identified 2 counter-examples of pNF1m tumors sensitive to CDK4/6i. These pts expressed relatively low NF1m AF, ranging 0.1% - 0.5% with a mean MAF 0.3%. Another pNF1m pt had intrinsic resistance to initial CDK4/6i but was sensitive to later-line CDK4/6i. In the subgroup of pts with VUS-NF1m (n = 18), a more mixed picture of resistance and sensitivity was seen. 8 pts had intrinsic or acquired resistance, 8 pts had NF1m tumors sensitive to CDK4/6i, and 1 pt had evidence of both; 61% (n = 11) of pts expressed alterations in other resistance mediating genes. 1 pt stopped therapy due to toxicity rather than PD. Conclusions: Our work demonstrates that tumor expression of pNF1m may be associated with CDK4/6i resistance in pts with HR+/HER2- MBC, and allele fraction could be predictive of drug susceptibility. Tumors harboring VUS had varied sensitivity, suggesting that some of these mutations may not be pathogenic, and counter-examples of pNF1m MBC benefiting from CDK4/6i plus ET highlight the complexities in predicting drug response based on single gene alteration. Future effort is warranted to explore the potential impact of NF1 on CDK4/6i resistance, as well as the potential role for therapies targeting the MAPK pathway in this patient population. Citation Format: Maxwell R. Lloyd, Lianne Ryan, Arielle J. Medford, Jennifer C. Keenan, Laura M. Spring, Neelima Vidula, Beverly Moy, Dejan Juric, Leif Ellisen, Aditya Bardia, Seth A. Wander. Investigating NF1 Mutations in Circulating Tumor DNA of Patients with Hormone-receptor Positive (HR+) Breast Tumors Resistant to CDK4/6 Inhibition (CDK4/6i): A Retrospective Clinical Analysis [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-13-07.
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Owens, Barry M. "The Effect of Different Drying Methods for Single Step Adhesive Systems on Microleakage of Tooth Colored Restorations." Journal of Contemporary Dental Practice 4, no. 1 (2003): 1–9. http://dx.doi.org/10.5005/jcdp-4-1-1.
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Abstract The purpose of this in vitro study was to evaluate microleakage of tooth colored restoratives and accompanying single step adhesive systems using two drying methods (syringe air versus “sponge” applicator blotting). Eighty teeth were randomly assigned to four material groups. Class V cavity preparations, located half in enamel and half in cementum at the cementoenamel junction (CEJ), with a 1.0 mm enamel bevel were completed. The adhesive/composite groups included: (1) Single-Bond/Z-100 Composite, (2) Prime & Bond 2.1/Dyract AP Compomer, (3) OptiBond Solo Plus/Prodigy Composite, and (4) Scotchbond MultiPurpose/Z- 100 Composite. Each material group (n=20), consisted of preparation Subgroups dried with syringe air (A), (n=10) and sponge applicators (B), (n=10). The preparations were conditioned, rinsed, and gently dried followed by placement of the primer/adhesive and restorative materials. All teeth were thermocycled, stained with methylene blue dye, invested in clear acrylic resin, and sectioned longitudinally through the center of the restoration. Readings were taken at the occlusal and gingival surface positions of each restoration section. A ratio (%) of wall length to amount of leakage along each wall was established. One-way Analysis of Variance (ANOVA) testing revealed: (1) no significant (p<0.05) differences existed between materials at the occlusal surface position in Subgroups A and B (syringe vs. applicator drying), (2) significantly (P<0.05) greater leakage of OptiBond Solo Plus compared to Single-Bond, Prime & Bond 2.1, and Scotchbond MultiPurpose at the gingival surface position in Subgroups A and B, (3) significantly (p<0.05) greater leakage of OptiBond Solo Plus compared to Single-Bond and Scotchbond MultiPurpose, combining the occlusal/gingival surface position scores, (4) no significant difference existed between Single- Bond Subgroups A/B, OptiBond Solo Plus Subgroups A/B, Scotchbond MultiPurpose Subgroups A/B, (5) significantly (p<0.05) greater leakage of Prime & Bond 2.1 Subgroup B compared to Subgroup A, (6) no significant (p<0.05) difference existed between material groups, except OptiBond Solo Plus (occlusal vs. gingival surface position), (7) no significant (p<0.05) difference between Single-Bond, OptiBond Solo Plus, and Scotchbond MultiPurpose comparing both Subgroups, same materials, and surface positions, and (8) no significant (p<0.05) difference existed between Prime & Bond 2.1, comparing both Subgroups, occlusal surface position. In the present study, significantly greater leakage was revealed with OptiBond Solo Plus compared to the other material groups, especially at the gingival surface positions. Significantly greater leakage was also recorded with OptiBond Solo Plus and Prime & Bond 2.1 sponge applicator drying as compared to the same materials, syringe air drying. Citation Owens BM. The Effect of Different Drying Methods for Single Step Adhesive Systems on Microleakage of Tooth Colored Restorations. J Contemp Dent Pract 2003 February;(4)1:001-009.
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Candido, Kenneth D. "Digital Subtraction Angiography Does Not Reliably Prevent Paraplegia Associated with Lumbar Transforaminal Epidural Steroid Injection." Pain Physician 6;15, no. 6;12 (December 14, 2012): 515–23. http://dx.doi.org/10.36076/ppj.2012/15/515.
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Digital subtraction angiography (DSA) has been touted as a radiologic adjunct to interventional neuraxial procedures where it is imperative to identify vascular compromise during the injection. Transforaminal epidural steroid injections (TFESI) are commonly performed interventions for treating acute and chronic radicular spine pain. We present a case of instantaneous and irreversible paraplegia following lumbar TFESI wherein a local anesthetic test dose, as well as DSA, were used as adjuncts to fluoroscopy. An 80-year-old man with severe lumbar spinal stenosis and chronic L5 radiculopathic pain was evaluated at a university pain management center seeking symptomatic pain relief. Two prior lumbar interlaminar epidural steroid injections (LESI) provided only transient pain relief, and a decision was made to perform right-sided L5-S1 TFESI. A 5-inch, 22-gauge Quincke-type spinal needle with a curved tip was used. Foraminal placement of the needle tip was confirmed with anteroposterior, oblique, and lateral views on fluoroscopy. Aspiration did not reveal any blood or cerebrospinal fluid. Digital subtraction angiography was performed twice to confirm the absence of intravascular contrast medium spread. Subsequently, a 0.5mL of 1% lidocaine test dose was performed without any changes in neurological status. Two minutes later, a mixture of one mL of 1% lidocaine with 80 mg triamcinolone acetonide was injected. Immediately following the completion of the injection, the patient reported extreme bilateral lower extremity pain. He became diaphoretic, followed by marked weakness in his bilateral lower extremities and numbness up to his lower abdomen. The patient was transferred to the emergency department for evaluation. Magnetic resonance imaging (MRI) of the lumbar and thoracic spine was completed 5 hours postinjection. It showed a small high T2 signal focus in the thoracic spinal cord at the T7-T8 level. The patient was admitted to the critical care unit for neurological observation and treatment with intravenous methylprednisolone. Follow-up MRI revealed a hyper-intense T2 and short-tau inversion recovery signal in the central portion of the spinal cord beginning at the level of the T6 superior endplate and extending caudally to the T9-T10 level with accompanying development of mild spinal cord expansion. The patient was diagnosed with paraplegia from acute spinal cord infarction. At discharge to an acute inpatient rehabilitation program, the patient had persistent bilateral lower extremity paralysis, and incontinence of bowel and bladder functions. In the present patient, DSA performed twice and an anesthetic test dose did not prevent a catastrophic spinal cord infarction and resulting paraplegia. DSA use is clearly not foolproof and may not be sufficient to identify potentially life-or-limb threatening consequences of lumbar TFESI. We believe that this report should open further discussion regarding adding the possibility of these catastrophic events in the informed consent process for lumbar TFESIs, as it has for cervical TFESI. Utilizing blunt needles or larger bevel needles in place of sharp, cutting needles may minimize the chances of this event occurring. Considering eliminating use of particulate steroids for TFESI should be evaluated, although the use of nonparticulate agents remains controversial due to the perception that their respective duration of action is less than that of particulate steroids. Key words: Digital subtraction angiography, transforaminal epidural steroid injections, paraplegia, chronic low back pain.
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Yangirov, Ilgiz F., Albert R. Khalikov, Evgeny M. Fedosov, Andrey V. Lobanov, Tagir R. Teregulov, Denis V. Maksudov, and Andrey V. Styskin. "ELECTROMECHANICAL VIBRATION TRANSDUCER WITH A CLOSED SPIRAL SECONDARY ELEMENT AND IMPROVED CHARACTERISTICS." Electrical and data processing facilities and systems 19, no. 3 (2023): 118–32. http://dx.doi.org/10.17122/1999-5458-2023-19-3-118-132.
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Relevance The development of new designs of electromechanical vibration transducers (EMVT) is an urgent task and is caused by the need to create devices that meet to one degree or another many, often contradictory requirements for accuracy and measurement limits, frequency range, sensitivity, overall dimensions, weight, cost, performance characteristics, etc. An important prerequisite for solving the set tasks is the study and development of new promising structural elements of electromechanical converters, materials, components, special production processes. The rapid development of science and technology causes a great variety and complexity of automatic control systems. Invariant, self-adjusting and other complex information-measuring and control systems are created, to which increased requirements are imposed. The modern development of automated monitoring and control systems for various technological and physical processes is characterized by the widespread use of primary means of collecting and processing information. At the same time, electromechanical vibration transducers EMVPsensors of vibration parameters are a link in any information-visual or control system and practically determine its metrological characteristics. Losses in the accuracy and reliability of the final result associated with unsuccessful use of the sensor cannot be restored by the most advanced information conversion system. The range of industrially produced vibration sensors is limited, and their effective operation and evaluation of experimental results is very difficult. The lack of clear recommendations for choosing one type of sensor or another, sound methods of engineering calculations and experimental studies, and analysis of limiting operational and technological capabilities has led to the fact that many types and designs of sensors turned out to be unviable. A large number of publications related to the design of new designs of vibration sensors for various purposes and the improvement of already known ones allows us to judge the continued interest of developers in this class of devices, especially with the development of technical robots and flexible modules. The lack of fundamental theory and engineering methods for calculating the static characteristics of electric motors in the mode of both a sensor and a motor with a spiral electrically conductive element limits the possibility of their rational design for information-measuring and control systems. Therefore, the tasks of researching and creating highly efficient EMVPs with a spiral secondary element that most fully satisfy the special requirements of control systems are relevant. Aim of research To investigate a vibration transducer (EMVT) with a closed spiral secondary element in the mode of generating low-frequency vibrations and improving mechanical data due to the execution of longitudinal slits with a bevel in a spiral electrically conductive spring. Research methods Literary review and patent study, methods of mathematical modeling and experimental studies of vibration oscillations. Results For the first time, a method and methodology have been developed for the design of electromechanical vibration converters with a spiral secondary element with theoretical and experimental confirmation of the main obtained positions. A full-scale sample with theoretical provisions was developed, a patent of the Russian Federation was obtained, the possibility of using a structural solution in household devices (tablets, laptops, electronic watches, nanorabototechnics, vascular medicine and cardiology, information transmission as GPS u GSM elements, etc.) was shown.
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Reyes-Quintos, Maria Rina T. "Pediatric Rigid Bronchoscopy for Foreign Body Removal." Philippine Journal of Otolaryngology-Head and Neck Surgery 24, no. 1 (June 15, 2009): 39–41. http://dx.doi.org/10.32412/pjohns.v24i1.719.
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Rigid bronchoscopy is a procedure that is performed in order to directly visualize the upper and lower airway, and is carried out for either a diagnostic or therapeutic purpose. Suspected foreign body (FB) aspiration is the most common indication for performing this procedure in the pediatric age group at the Philippine Children’s Medical Center where a recent census (May 2008 to April 2009) showed that of 21 cases where rigid bronchoscopy was performed, 10 were for suspected FB aspiration. A review of 101 cases in the same institution showed that the average age of patients with FB aspiration was 2 years and the most common item aspirated was a peanut followed by the atis (sweetsop) seed and chicken bone chips. The most common inorganic foreign body was an earring and “whistle” (which broke off from a toy).1 It is more common in males probably because of their usually more active nature and is frequently found in the right mainstem bronchus, where the FB more easily lodges - being straighter, shorter and wider in diameter. FBs are life-threatening events in children that require early diagnosis and prompt successful management.2
A good history, physical examination and analysis of diagnostic tests are vital in every situation. In most cases, the child’s aspiration of the foreign object is a witnessed event 3 and this history of aspiration is the most sensitive diagnostic tool. The main symptoms include choking, prolonged cough, and dyspnea. Abnormal physical examination findings are found in 67% to 80% of cases and include unilaterally decreased breath sounds, wheezing and stridor.2, 4 Radiographic procedures may show abnormal findings in only about 68-86% of cases.4 5 The most useful radiographs requested are the chest posteroanterior (anteroposterior in infants and small children) and lateral views which may help localize the impaction site when the object aspirated is radiopaque.3 However, most inhaled FBs are radiolucent, and their presence can be suspected by obtaining inspiration and expiration views to demonstrate unilateral hyperinflation. Other suggestive features include atelectasis, pneumothorax and pneumonia. These indirect radiologic features of FB inhalation are present in 76% of cases.2, Where inspiration and expiration views cannot be obtained, as in very young children, left and right decubitus views may be helpful. 6 Fluoroscopic studies may also be obtained along with the plain radiographs, however, specificity and sensitivity are not very high.4 Virtual bronchoscopy may also be used in patients with suspected FB aspiration. Virtual bronchoscopy which uses multislice computerized tomography (MDCT) with realistic 3-dimensional reconstruction may be helpful in detecting and localizing the FB prior to any surgical procedure and thus decreasing the number of patients needing diagnostic bronchoscopies.7 Flexible fiberoptic bronchoscopy under local anesthesia and premedication may also be performed in cases of suspected FB aspiration wherein clinical and radiologic findings are not consistent with FB aspiration. When no FB is visualized, the patient is saved a rigid bronchoscopic procedure under general anesthesia.8 Flexible fiberoptic bronchoscopy is also used therapeutically to remove FBs in the bronchus, however, successful removal is more common with rigid bronchoscopy.
All the necessary instruments needed for the procedure must be prepared. As much as possible 2 of each instrument are prepared: 2 bronchoscopes (one estimated from the age and size of the child and one smaller than that – just in case!), 2 suction devices (if one gets clogged up, the other one is ready) and 2 forceps. The peanut forceps is ideal, not only for peanuts but usually for other nuts as well; the alligator forceps is useful for relatively flat foreign bodies; while the “jaw type” forceps appears to be useful for everything else.9 The instruments are then tried, to check if they are in working order before commencement of anesthesia. This involves checking the transparency of the glass window plug, ensuring that the light source and the proximal prismatic light deflector are both illuminating, and trying out all the forceps and suction tips. It is best to try the instruments on an object similar to what the child aspirated.3 The surgical assistant, nurse and instruments are usually on the right (if the surgeon is right-handed) and anesthesiologist on the left. The suction and bronchoscope are then made ready. Knowledge of the anatomy of the tracheobronchial tree is imperative to be able to navigate through this area while looking for the FB.
The use of optical forceps with mounted rod-lens telescopes has made the removal of airway FBs simpler, quicker and safer. These new devices have led to decreased complication rates and fewer missed or incomplete FB removals. While access to FBs located in the distal small segmental bronchi especially in very young children may be limited with the use of optical forceps,10 this can be overcome by removal of the connecting bridge to allow the optical forceps to be passed distal to the tip of the bronchoscope.
An anesthesiologist familiar with the procedure must be called in. It is very important to have discussed the case and the procedure with the anesthesiologist prior to the operation to minimize confusion and promote harmony. Most anesthesiologists have become at ease with giving intravenous general anesthesia which circumvents the use of potentially noxious gases. Assisted spontaneous ventilation can avoid the need for muscle relaxation and paralysis so that the wake-up time is shortened. Intravenous general anesthesia with propofol and assisted spontaneous ventilation is currently the frequently used anesthetic technique for rigid bronchoscopy although volatile agents and gases are still used.11,12
The patient is placed supine on the operating table. A shoulder roll is not required. After induction of anesthesia, the patient is hyperventilated to 100% oxygen saturation to take full advantage of operating time.3 A topical anesthetic (lidocaine or tetracaine) is sprayed into the laryngeal area and distally into the trachea to lessen stimulus and pain, thus lowering the level of the anesthetic agent used and minimizing the possible occurrence of laryngospasm after the procedure.12 The state of dentition is inspected and a tooth guard placed over the upper teeth. Although it is possible to do bronchoscopy directly without using a laryngoscope, it is more expedient to use the laryngoscope (with the left hand) to visualize the larynx.
The assistant (most likely the ORL resident but occasionally, a nurse) hands over the bronchoscope (to the right hand) without the glass window plug initially (because it may fog up or fall off) and the bronchoscope is inserted by looking through the bronchoscope as it passes through the larynx. Rotating the bronchoscope by 900 (with the axis of the lip in the anteroposterior axis of the glottis chink) is often useful for easier bronchoscopic insertion.2 Never force the bronchoscope into the larynx – if there is difficulty, reposition the laryngoscope to better visualize the larynx. Where exposure of the larynx is adequate, inability to pass the bronchoscope may be due to the bronchoscope lip hitting a vocal fold instead of entering the glottic chink. Another possibility is that the bronchoscope is too large to fit through a narrowed subglottis. The laryngoscope is removed once the bronchoscope has been inserted and the anesthesiologist connects the anesthetic tube to the standard 15-mm adapter of the bronchoscope and the glass window plug is inserted (this is again removed when the forceps is introduced or suctioning needed). A 0o telescope of the appropriate size may be inserted at this time or even during the initial insertion of the bronchoscope.
The left hand is placed over the tooth guard and the thumb and index finger are used to support the bronchoscope being held in the right hand, much like a billiard cue. The left thumb lifts the bronchoscope off the tooth guard to enable the bronchoscope to be advanced without resistance. The bronchoscope is advanced slowly, always ensuring that the lumen is clearly in view, and suctioning whenever needed. Once the carina is seen, the main bronchus, where the FB is likely to be located, is then entered. Turn the head to the left to enable passage into the right main bronchus, and then to the right to enter the left main bronchus. Some degree of neck flexion can also be helpful in aligning the main bronchus. The bronchoscope is advanced until it is as near as possible to the FB to allow accurate suction of secretions so that the surgeon can determine how best to orient the forceps during application. The bronchoscope is then slightly withdrawn to allow the forceps to be freely inserted beyond the bronchoscope. The forceps are opened as widely as possible as this stretches the airway walls and allows the foreign body to fall into the jaws of the forceps which is then firmly grasped. Care must be taken not to push the FB further down the airway. If the FB fits through the bronchoscope, then it is pulled right through without removing the bronchoscope. However, if the FB does not fit through the bronchoscope, then the bronchoscope has to be withdrawn with the FB trailing behind held by the forceps. It is important to keep your eyes (and hands) on the bronchoscope and forceps at all times.
The FB may become caught in the larynx or dropped into the trachea, causing complete airway obstruction. This possibility should always be anticipated and equipment be able to deal with this needs to be readily at hand. To prevent the FB being lost at the laryngeal inlet, the bevel of the bronchoscope is moved around over the FB by rotating the bronchoscope 900 and the bronchoscope is slightly tilted down at this area. A firm grip on the forceps with the FB must be maintained and hopefully, it is still there when the forceps is removed from the oral cavity. If the FB has been removed from the tracheo-broncial tree, but is not found in the forceps, the naso-oro-hypo pharynx should be checked in addition to a repeat bronchoscopy.
All throughout the procedure, it is imperative to listen to the sound of the oxygen saturation monitor for signs of desaturation and to inquire from the anesthesiologist regarding the condition of the patient. If desaturation occurs, the bronchoscope is moved back out of the bronchus and into the trachea to allow the anestheshiologist to ventilate the patient through the bronchoscope adaptor. If this is due to a large FB that slipped while in the trachea, then, the FB must be removed right away or pushed back into the bronchus to regain the airway.
Once the FB is removed , a second bronchoscopic examination is done to check for any pooling of secretions or blood that may need to be suctioned or for any remnant of the FB- which may have accidentally separated from the bigger piece- that has to be retrieved. Small pieces can often be removed by suctioning.
Rarely, a tracheostomy may have to be performed for a FB that, during extraction, will not fit through the laryngeal inlet. Tracheotomy is performed while the bronchoscope is in place and with the forceps grasping the FB. The FB is extracted through the tracheostoma. Afterwards, tracheostoma is closed with sutures and regular wound care is initiated.
If the procedure took less that an hour with minimal trauma, then the child is assisted with ventilation until he/she recovers full spontaneous respiration. A dose ofteroids may also be given (I.V. Dexamethasone, 1.0 to 1.5 mg/kg; maximum, 20 mg). The patient is brought to the post-anesthesia room and observed.
Delayed diagnosis and intervention (24 hours or more) were found to be related to higher complication rates such as recurrent or chronic pulmonary infections and prolonged hospital stay. 13 Thus the need for early diagnosis and treatment of cases with suspected FB aspiration.
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"Beverly Cleary." Choice Reviews Online 28, no. 10 (June 1, 1991): 28–5573. http://dx.doi.org/10.5860/choice.28-5573.
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Strauch, Bruce. "Bet You Missed It--What do Beverly Cleary and small presses have in common?" Against the Grain 28, no. 2 (April 1, 2016). http://dx.doi.org/10.7771/2380-176x.7328.
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Kaup, Soujanya, Dimple Kondal, Siddharudha Shivalli, and John Buchan. "Statistical analysis plan for the phaco TIp position during clear corneal Phacoemulsification Surgery (TIPS) randomized controlled trial." Trials 25, no. 1 (February 22, 2024). http://dx.doi.org/10.1186/s13063-024-07979-0.
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Abstract Background Cornea is the most important refractive media in the eye, and damage to the corneal endothelium is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The role of phaco tip position during phacoemulsification on corneal endothelial damage is ambiguous, and there is no consensus regarding the most cornea-friendly phaco tip position (bevel-up or bevel-down). The objective of the trial is to compare the effect of phaco tip position (bevel-up vs. bevel-down) during phacoemulsification using direct chop technique on corneal endothelial cell count. Methods and design TIPS is a randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio. A total of 480 eligible participants, aged > 18 years with immature cataract, will be randomly allocated into bevel-up and bevel-down groups at two centres. Randomisation will be stratified according to the cataract grade. The primary outcome is postoperative endothelial cell count at 1 month. Secondary outcomes are central corneal thickness on postoperative days 1, 15, and 30 and difference in intraoperative complications. Conclusion In this paper, we describe the detailed statistical analysis plan (SAP) for the TIPS trial, which was prepared prior to database lock. The SAP includes details of planned analyses and unpopulated tables, which will be reported in the publications. We plan to lock the database in July 2023 and publish the results later in the same year. SAP Version 0.1 (dated: 28 April 2023) Protocol version:2.0 Trial registration Clinical Trial Registry of India CTRI/2019/02/017464. Registered on 5 February 2019; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=29764&EncHid=&userName=2019/02/017464
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Ye, Benjamin B., Ganquan Song, and Jeff J. Ye. "In situ plasma pin-up clean process for backside bevel polymer removal, defect reduction, and queue time relaxation." Journal of Vacuum Science & Technology B 42, no. 2 (February 5, 2024). http://dx.doi.org/10.1116/6.0003300.
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Polymeric residues and films of various thicknesses on the wafer backside and the edge frontside bevel and backside are known to cause substantial yield losses. An additional ex situ bevel etch step can clear away these buildups from the edge bevel area but not from the wafer backside. In this paper, we demonstrate a novel and innovative in situ pin-up plasma clean step that can effectively remove polymers from both the wafer backside and the edge bevel areas, eliminating the need for the bevel etch step. A physical analysis of blanket test wafers and patterned product wafers that have underwent the pin-up clean step in inductively coupled plasma and capacitively coupled plasma etch systems reveals that the pin-up clean step can reduce defect counts on product wafers and improve manufacturing cycle time and throughput by relaxing the queue time constraint.
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Rase, Marissa, Mark Hanlon, Le Ho, Doug Duriez, and Cathy Zhao. "Vial coring and fragmentation incidence after angled penetration of rubber stoppers with single-use hypodermic needles." Pharmaceutical Technology in Hospital Pharmacy 6, no. 1 (January 1, 2021). http://dx.doi.org/10.1515/pthp-2021-0004.
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Abstract Objectives Particles due to fragmentation present a clear risk to the patient. Reported fragmentation rates vary, and an insertion angle at 45°, as opposed to 90°, has been proposed as a mitigation strategy. So, this study evaluated the fragmentation rates induced by single-use hypodermic needles using different angled penetration techniques. Methods Needles underwent fragmentation testing using two penetration techniques. In method 1, the needle was inserted through the stopper at 45° and rotated to 90° upon exiting the stopper underside, and in method 2 the needle was rotated only after the bevel was fully enveloped by the stopper. Methods were tested with 18, 20, and 22-gauge needles with bevel faced up, down, and sideways. Fragmentation data sets were subjected to ANOVA and a fit to a General Linear Model was attempted to ascertain the significance of needle size, bevel position, and penetration method; p-values less than 0.05 indicated statistical significance. Results Incidence varied from 0 to 49% and depended on the test method. Needles larger than 22-gauge induced fragmentation the most when the bevel was down. The bevel up position induced fragmentation the least. Generation of large fragments designated “cores” depended on all factors examined, and generation of small fragments designated “fragments” depended on all factors except for the penetration method. Conclusions Clinical context and intended application need to be communicated to manufacturers and considered for functional testing when devising end-user recommendations which must reflect a combination of factors.
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Yang, Min Jae, Jaihwan Kim, Se Woo Park, Jae Hee Cho, Eui Joo Kim, Yun Nah Lee, Dong Wook Lee, Chan Hyuk Park, and Sang Soo Lee. "Comparison between three types of needles for endoscopic ultrasound-guided tissue acquisition of pancreatic solid masses: a multicenter observational study." Scientific Reports 13, no. 1 (March 4, 2023). http://dx.doi.org/10.1038/s41598-023-30920-5.
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AbstractIt is debatable which needle has clear superiority of diagnostic performance in endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) of solid pancreatic masses. This study aimed to compare the performance of three needles and determine the variables that affect diagnostic accuracy. From March 2014 to May 2020, 746 patients with solid pancreatic masses who underwent EUS-FNB using three types of needles (Franseen needle, Menghini-tip needle, and Reverse-bevel needle) were retrospectively reviewed. Multivariate analysis using a logistic regression model was used to identify factors related to diagnostic accuracy. There were significant differences between the groups regarding the procurement rate of the histologic and optimal quality cores (Franseen vs. Menghini-tip vs. Reverse-bevel: 98.0% [192/196] vs. 85.8% [97/113] vs. 91.9% [331/360], P < 0.001 and 95.4% [187/196] vs. 65.5% [74/113] vs. 88.3% [318/360], P < 0.001, respectively). The sensitivity and accuracy using histologic samples were 95.03% and 95.92% for Franseen, 82.67% and 88.50% for Menghini-tip, and 82.61% and 85.56% for Reverse-bevel needles, respectively. In direct comparison between the needles using histologic samples, the Franseen needle showed significantly superior accuracy than the Menghini-tip (P = 0.018) and Reverse-bevel needles (P < 0.001). Multivariate analysis indicated that tumor size ≥ 2 cm (odds ratio [OR] 5.36, 95% confidence interval [CI] 3.40–8.47, P < 0.001) and fanning technique (OR 1.70, 95% CI 1.00–2.86, P = 0.047) were significantly associated with an accurate diagnosis. EUS-FNB using the Franseen needle enables the acquisition of a larger and more adequate histologic core tissue and achieves an accurate histological diagnosis when using the fanning technique.
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Lin, Chi-Lun, Yu-Chen Jheng, Si Yen Ng, and Chun Jung Yen. "Design Optimization of Nonrotational and Rotational Needle Insertion for Minimal Cutting Forces." Journal of Medical Devices 14, no. 2 (February 18, 2020). http://dx.doi.org/10.1115/1.4045725.
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Abstract The needle insertion is widely used in many medical procedures, particularly in the needle biopsy. The cutting force occurred during the insertion process has a significant effect on the cutting outcome. This paper focuses on minimizing the cutting force for two conventional needle insertion methods, the nonrotational and rotational needle insertion. For the nonrotational needle insertion, the secondary bevel angle and angle of rotation, which are two used for grinding the back-bevel and lancet needles, are considered. For the rotational needles, the effects of the insertion speed and the slice-push ratio on the cutting force are investigated. Levels of these design variables are defined using practical needle design configurations found in the literature. A clear trend of the cutting force decreases as the increase of the inclination angle was observed. The optimal cutting force of nonrotational needles was found as 0.242 N with inclination angle of 69.25 deg for the lancet needle and 0.254 N with inclination angle of 66.24 deg for the back-bevel needle. The optimization of rotational needles yielded a configuration of slice-push ratio as 4.66 and insertion speed as 2.01, which resulted in a minimal cutting force of 0.22 N. Besides, the main effects of and the interaction between the design variables on the cutting force are obtained and discussed. These results provide essential information for selecting geometric and cutting speed parameters for the design of nonrotational and rotational needles.
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Mastrone, Marco Nicola, and Franco Concli. "CFD simulations of gearboxes: implementation of a mesh clustering algorithm for efficient simulations of complex system’s architectures." International Journal of Mechanical and Materials Engineering 16, no. 1 (August 5, 2021). http://dx.doi.org/10.1186/s40712-021-00134-6.
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AbstractIn the last decade, computer-aided engineering (CAE) tools have become a determinant factor in the analysis of engineering problems. In fact, they bring a clear reduction of time in the design phase of a new product thanks to parametrical studies based on virtual prototypes. The application of such tools to gearboxes allowed engineers to study the efficiency and lubrication inside transmissions. However, the difficulties of handling the computational domain are still a concern for complex system configurations. For this reason, the authors maintain that it is fundamental to introduce time efficient algorithms that enable the effective study of any kind of gear, e.g., helical and bevel configurations. In this work, a new mesh handling strategy specifically suited for this kind of studies is presented. The methodology is based on the Global Remeshing Approach with Mesh Clustering (GRAMC) process that drastically reduces the simulation time by minimizing the effort for updating the grids. This procedure was tested on spur, helical, and bevel gears, thus demonstrating the flexibility of the approach. The comparison with experimentally measured power losses highlighted the good accuracy of the strategy. The algorithm was implemented in the opensource software OpenFOAM®.
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xin, kang, Junsheng Cheng, Ping Wang, Jian Wang, Zuanyu Zhu, and Yu Yang. "A novel ensemble convex hull-based classification model for bevel gearbox fault diagnosis." Measurement Science and Technology, December 5, 2022. http://dx.doi.org/10.1088/1361-6501/aca8c1.
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Abstract Kernel-based geometric learning model has been successfully applied in bevel gearbox fault diagnosis. However, due to its shallow architecture and the faultiness of sensitivity to noise and outliers, its generalization ability and robustness need to be further improved. Ensemble learning can improve the classification accuracy of sub-classifiers, but it is effective only when the sub-classifiers meet the requirements of difference and accuracy at the same time. However, as strong classifiers, Geometric learning models are difficult to produce sub-classifiers with differences. To solve these problems, this study proposes a novel ensemble model, ensemble convex hull-based (EnCH) classification model. CH has the advantages of clear geometric meaning and is easy to deform. Considering the clustering characteristics of the sample points in the feature space, this paper, from both distance and density, performs differential shrinkage deformation on the original CH. For one thing, this can produce differential CHs to build differential sub-classifiers to ensemble. Besides, it can suppress the interference of noise and outliers to improve robustness. The results of our experiments on the fault dataset of bevel gear box indicate that EnCH classification model can improve the generalization of geometric learning model and has excellent tolerance to noise and outliers.
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Grabovic, Eugeniu, Alessio Artoni, and Marco Gabiccini. "Holistic Optimal Design of Face-Milled Hypoid Gearsets." Journal of Mechanical Design, March 30, 2023, 1–25. http://dx.doi.org/10.1115/1.4062236.
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Abstract The aim of this paper is to present a holistic framework to design optimized spiral bevel and hypoid gearsets with accurate finite element simulations in the loop. Starting from the basic transmission data, we first size gear and pinion blanks, and then we synthesize the basic machine-tool settings required to generate the two toothed members. This first step represents the macro-geometry design phase and its outcome is a conjugate spiral bevel or hypoid gearset. The second design phase is represented by the definition of the optimal pinion micro-geometry. This is formulated as a multi-objective optimization problem (MOOP) where the obtained optimal ease-off is guaranteed to be manufacturable. To this end, an original strategy is presented where the search for the pinion optimal tooth surface happens in the space of the coefficients of a polynomial representation of its micro-topography. However, thanks to a fast identification algorithm that can handle all the higher-order motions, the ideal ease-off is projected onto set of machine-tool setting, thus ensuring manufacturability from the outset. It is worth remarking that the objective functions on the MOOP are evaluated by calling as a back-end solver one of the most accurate LTCA software available on the market. A dedicated parallel implementation of such MOOP allows to maintain computation times within very reasonable limits. A fully worked out numerical test case clearly demonstrates that the whole procedure far surpasses the current state of the art.
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Michael, Tsatsos, Giachos Ioannis, Martini Ferdinardo, and Athanasiadis Ioannis. "Endothelium sparing – Air-assisted wedge resection for the treatment of pellucid marginal degeneration." Indian Journal of Ophthalmology, December 26, 2023. http://dx.doi.org/10.4103/ijo.ijo_3033_22.
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Abstract To describe the surgical technique of performing a wedge resection of a 1 mm area of inferior corneal stroma using stromal air injection assisted separation sparring the endothelium in a patient with bilateral Pellucid Marginal Degeneration. 68-year-old male Caucasian advanced, non progressive. A 30G needle on a 1 ml air-filled syringe injects air into the stromal lamellae with the bevel up, leading to stromal emphysema. An MVR blade is used to incise the marked area until clear corneal tissue is seen. The incised areas are separated with a lamellar dissector, and the crescentic area is excised. The lips of the wound are approximated with 10-0 Prolene sutures. This surgical approach leads to adequate management of the Pellucid Marginal Degeneration without injury to the endothelium, ensuring reduced antigenic input and maintenance of the architectural integrity of the eye.
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Eastwick, Carol N., and Graham Johnson. "Gear Windage: A Review." Journal of Mechanical Design 130, no. 3 (February 14, 2008). http://dx.doi.org/10.1115/1.2829983.
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The efficiency of power and propulsive systems is increasingly being targeted as a means of reducing environmental impact. This has caused a renewed interest in industry in the losses associated with meshing gears. Gearbox efficiency varies from 98% to 99% for the best designed high power applications, but that can still equate to losses in megawatts. There are different mechanisms for losses that have been identified within gearboxes; these are meshing losses, bearing losses, windage losses, and churning losses. Depending on the application, the relative importance of these mechanisms varies. This paper reviews information on windage power loss. The motivation for this is that for some applications, this power loss can be a significant component, particularly lightly loaded high-speed applications. For instance, within some aeroengines, gears are mounted internally within bearing chambers. The component of windage power loss becomes significant in this case, and the flows associated with windage power loss have a significant impact on the amount of heat transferred to the oil within the chamber, which is a critical design consideration. This paper provides a review of experimental investigations and available models of gear windage power loss for spur, helical, and bevel gears. The aim of the review is to provide a comprehensive compilation of published information on windage power loss to assist gearbox designers in identifying relevant experimental and modeling information. While it is clear from the review of published work that the rotational speed, gear geometrical parameters, degree of confinement, and density of the fluid surrounding the gear are important, the degree of effect and general solutions for reducing power loss are less clear.
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ARDENGH, José Celso, Vitor Ottoboni BRUNALDI, Mariângela Ottoboni BRUNALDI, Alberto Facuri GASPAR, Jorge Resende LOPES-JÚNIOR, Ajith Kumar SANKARANKUTTY, Rafael KEMP, and José Sebastião dos SANTOS. "IS THE NEW PROCORE 20G DOUBLE FORWARD-BEVEL NEEDLE CAPABLE TO OBTAIN BETTER HISTOLOGICAL SAMPLES BY ENDOSCOPIC ULTRASOUND FOR DIAGNOSING SOLID PANCREATIC LESIONS?" ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 33, no. 4 (2020). http://dx.doi.org/10.1590/0102-672020200004e1554.
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ABSTRACT Background: It is important to obtain representative histological samples of solid biliopancreatic lesions without a clear indication for resection. The role of new needles in such task is yet to be determined. Aim: To compare performance assessment between 20G double fine needle biopsy (FNB) and conventional 22G fine needle aspiration (FNA) needles for endoscopic ultrasound (EUS)-guided biopsy. Methods: This prospective study examined 20 patients who underwent the random puncture of solid pancreatic lesions with both needles and the analysis of tissue samples by a single pathologist. Results: The ProCore 20G FNB needle provided more adequate tissue samples (16 vs. 9, p=0.039) with better cellularity quantitative scores (11 vs. 5, p=0.002) and larger diameter of the histological sample (1.51±1.3 mm vs. 0.94±0.55 mm, p=0.032) than the 22G needle. The technical success, puncture difficulty, and sample bleeding were similar between groups. The sensitivity, specificity, and diagnostic accuracy were 88.9%, 100%, and 90% and 77.8%, 100%, and 78.9% for the 20G and 22G needles, respectively. Conclusions: The samples obtained with the ProCore 20G FNB showed better histological parameters; although there was no difference in the diagnostic performance between the two needles, these findings may improve pathologist performance.
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Nordkvelle, Yngve. "Editorial Vol-1-Issue-1-2005." Seminar.net 1, no. 1 (December 6, 2005). http://dx.doi.org/10.7577/seminar.2533.
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Launching a new journal is a rare event - doing it electronically is even more rare. Given the subtext for the journal: “media, technology and lifelong learning”, the format might not be so surprising. Enthusiasts for electronic publishing underline that it acts as an alternative to the traditional publishing in a number of significant ways. It is far more affordable for independent actors to establish, it is a lot more reasonable to run, and in addition supports genuine academic virtues more effectively than traditional journals: results from research can be published faster, they are accessible for everyone with a PC hooked onto the Internet, it can serve formerly unrecognised academic communities and special interests with a platform, etc.Genevieve Brown and Beverly J. Irby give a brilliant account of the “whys” and “hows” they confronted while planning and launching their journal “Advancing Women in Leadership Journal”. Read their wonderful article in The Journal of Electronic Publishing.The most important, however, is the founding idea, what the editors suggest as their contribution to the current discourses in the field. Seminar.net is a title we find telling: it is about education, it is about teaching and learning, about democracy in the digital age and about didactics. Now, didactics has a significant position in educational theory in general. Behind the development of didactics, there is a long history of trying to formalise the “art of teaching”. Educational technology goes back to the ancient Greek, according to the historian of educational technology, Paul Saettler. Trying to make teaching meaningful to the student, efficient in its use of time and resources, coping with both the process of conveying meaning, cultural standards and upbringing as well as initiating the young into the world of adults is a complex activity. Inventing methods, tricks of the trade and rules of thumb, has, during history, been crucial in making training of teachers possible. In this sense didactics, has been the technology whereby teachers could act efficiently. One dimension of this technology is theoretical e.g. what researchers investigate and theorize. Another dimension is practical and material. The school building, classrooms, blackboards, textbooks – are all exponents, or representations of what we during history have conceived of as promoting teaching and learning. They are material expressions of the educational technology.The digital tools for information and communication technology have intensified the significance of a more thorough understanding of the media in education. Pedagogical innovations are clearly linked to innovations in methods for communication, its rhetoric and ability to mediate. The relation between the objective world and the subjective mind is a mediated relation. Comenius’ suggested that children would understand this relation when it was represented and mediated in ways that gave meaning to them. Language, images and the senses made it possible to induce from observation and logically connect them to former knowledge. It was the task of the teacher to make this mediation possible, and Comenius invented the modern textbook to aid teachers in their efforts. In many respects, modern educational technology, particularly the personal computer and the Internet provides education with the same mediating capacities.The articles of this first issue are invited contributions. Lars Qvortrup, adjunct professor of the Centre for media education at Lillehammer University College, director of KnowledgeLab.Dk as well as professor of Media at the University of Southern Denmark, gives a thorough introduction to the educational theory of Niklas Luhmann (1927-1998), the German sociologist. He played a major role in making Systems Theory applicable to social theory, and introduced a number of new insights to how the modern world functions. Qvortrup is one of Luhmann’s finest interpreters, who extends and develops his work into media and communications theory. In this article he shows how Luhmann’s theoretical notions fruitfully can stimulate developments in educational theory. David Hamilton, Ethel Dahlgren, Agneta Hult and Tor Söderström, University of Umeå, present a collaborative paper, which critically looks into the Swedish tradition of ”Folkbildning”. Folkbildning is deemed to be student-centred, participatory and constructivist, - a materialized version of the ideal of Bildung, in which conversation (Swedish: samtalet) is the fundamental tool. The authors question how various software handle this phenomenon, and seeks to develop a critique of their ability to support the genuine samtalet. As things are, students are confused by a multitude of “threads” and cross-postings that follow the trails intended by the tutors (or the engineers), and it is difficult to emulate the pedagogic practice with its “inherited values of liberal adult education (or folkbildning)” by the on-line education software of today. They finally compare this critique with the conclusions of the policy paper prepared by the On-line Distance Learning (ODL) Liaison Committee (created by the member networks of the European Distance Education Network (EDEN)).Our third contribution is from one of the leading researchers in adult education in the UK, senior lecturer Neil Selwyn, University of Cardiff. His paper delineates reflexivity as a phenomenon in the learning society, and asks whether the use of ICT in contemporary flexible education contribute to the reflexivity of the learner. The empirical research project is presented and a number of interesting conclusions made. The reflexivity of learners using ICT, is not necessarily an effect of using ICT. Some were living “reflexive” lives in many other aspects as well. The relation between reflexivity and flexible learning is in practice a very complex one. The image of the self-directed learner being a reflexive and autonomous entity, is an idealised image, and not representative of the average flexible learner.By these three contributions for our first issue, we hope to have stimulated readers to contribute with their own writing from their theoretical and empirical contexts!