To see the other types of publications on this topic, follow the link: Cleft palate.
Journal articles on the topic 'Cleft palate'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Cleft palate.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Lasma Azaria, Yohana. "MANAGEMENT IN CLEFT LIP AND PALATE SURGERY : A SYSTEMATIC REVIEW." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 9, no. 4 (April 17, 2023): 28–33. http://dx.doi.org/10.53555/nnmhs.v9i4.1646.
Full textAbstract:
Cleft lip and palate, sometimes referred to as labioplatoschizis, is one of the most common types of congenital disorders found in Indonesian babies. A person is said to have cleft lip and cleft palate if they have a cleft in their upper lip as well as a cleft in the roof of their mouth, which results in a direct connection between their nostril and mouth. This condition is also known as cleft lip and palate syndrome. This disorder could be hereditary or it could be acquired. Both the cleft lip and the cleft palate can happen on their own (just the cleft lip or just the cleft palate), or they can happen simultaneously. (cleft lip and cleft palate). The embryological process of facial structure creation is integrally related to the pathophysiology of orofacial clefts, which can occur on the lip (labioschisis), palate (palatoschisis), or both. Orofacial clefts can be divided into three categories: labioschisis, palatoschisis, and both. (also known as labiopalatoschisis). Clefts of the lip or palate are a possibility. Cleft lips are caused by the failure of the maxillary bone to fuse with the bones of the palate and the nasal passageway. No matter what kind of tissue is involved, the technique for surgical removal is the same. The surgeon will work to restore the patient's normal anatomy and physiology and will also make an effort to rehabilitate their mental health. There is an increased likelihood of death or morbidity in those who have cleft lips, palates, or labiopalatoschisis. Syndromes associated with cleft palate are associated with an increased risk of death and morbidity. Morbidity is increased when there are complications.
2
Russell, Kathleen A., Victoria M. Allen, Mary E. MacDonald, Kirsten Smith, and Linda Dodds. "A Population-Based Evaluation of Antenatal Diagnosis of Orofacial Clefts." Cleft Palate-Craniofacial Journal 45, no. 2 (March 2008): 148–53. http://dx.doi.org/10.1597/06-202.1.
Full textAbstract:
Objectives: To evaluate the changes in prevalence and antenatal detection of cleft lip with or without cleft palate and isolated cleft palate and to describe the association between anomalies and rates of antenatal diagnosis in Nova Scotia from 1992 to 2002. Design: This population-based cohort study employed the Nova Scotia Atlee Perinatal Database, the Fetal Anomaly Database, and IWK Cleft Palate Database in Halifax, Nova Scotia, Canada. Outcome Measures: Cleft type, mode of diagnosis, and associated abnormalities of orofacial clefts for liveborn infants, stillbirths, and second trimester terminations of pregnancy between 1992 and 2002 were determined. Results: There were 225 fetuses identified as having orofacial clefts. The overall prevalence of clefts was 2.1 in 1000 live births, and this prevalence did not change with time. The overall antenatal detection of cleft lip with or without cleft palate was 23%; however, there was improvement in detection of cleft lip with or without cleft palate from the years 1992 to 1996 (14%) to the years 1997 to 2002 (30%, p = .02). No isolated cleft palates were detected antenatally. Associated structural anomalies were seen in 34.2% of cases with orofacial clefts, and chromosomal abnormalities were associated with 9.8%. Conclusions: The prevalence of orofacial clefts in Nova Scotia has not changed from 1992 to 2002. The proportion of antenatally diagnosed cleft lip with or without cleft palate in Nova Scotia is consistent with rates reported in the literature and has increased from 1992 to 2002.
3
Heliövaara, Arja, and Jorma Rautio. "Craniofacial and Pharyngeal Cephalometric Morphology in Seven-Year-Old Boys with Unoperated Submucous Cleft Palate and without a Cleft." Cleft Palate-Craniofacial Journal 46, no. 3 (May 2009): 314–18. http://dx.doi.org/10.1597/07-211.1.
Full textAbstract:
Objective: To evaluate cephalometrically the craniofacial and pharyngeal morphology in 7-year-old boys with unoperated submucous cleft palate and to compare the findings with the morphology of 7-year-old boys without clefts. Setting and Patients: Thirty-two boys with unoperated submucous cleft palate and 49 boys without a cleft were compared retrospectively from lateral cephalograms taken at the mean age of 7 years (range, 5.5 to 8.6 years). Design: A retrospective case-control study. Outcome Measure: Linear and angular measurements were obtained from lateral cephalograms. A Student's t test was used in the statistical analysis. Results: The maxilla of the boys with submucous cleft palate was shorter and slightly more retrusive in relation to the cranial base than that of boys without clefts. Also, the mandible of the boys with submucous cleft palate was smaller, with a steeper mandibular plane. The relationship between the jaws was similar in both groups; although, those without clefts showed higher values for soft tissue maxillary prominence. In the pharyngeal area, the boys with submucous cleft palate had larger nasopharyngeal depths, smaller hypopharyngeal depths, and shorter soft palates than the boys without a cleft. Conclusions: This small study suggests that the boys with unoperated submucous cleft palate have minor distinctive morphological features in the maxillary, mandibular, and pharyngeal areas.
4
Agbenorku, P., M. Yore, K. A. Danso, and C. Turpin. "Incidence of Orofacial Clefts in Kumasi, Ghana." ISRN Plastic Surgery 2013 (May 15, 2013): 1–6. http://dx.doi.org/10.5402/2013/280903.
Full textAbstract:
Background. Cleft lip and cleft palate are among the most common orofacial congenital anomalies. This study is to establish Orofacial Clefts Database for Kumasi, Ghana, with a view to extend it to other cities in future to obtain a national orofacial anomaly database. Methods. A descriptive prospective survey was carried out at eleven selected health facilities in Kumasi. Results. The total number of live births recorded was 27,449. Orofacial anomalies recorded were 36, giving an incidence of 1.31/1000 live births or 1 in 763 live births. The mean maternal age of cleft lip/palate babies was 29.85 years (range 18–40 years). The male : female ratio for the orofacial anomalies babies was 1.3 : 1; the male : female ratio was 0.5 : 1 in the cleft lip group, 1.3 : 1 in the cleft lip and palate group, and 4 : 1 in the cleft palate group. The majority of clefts were unilateral (69.4%, n=25), with females (n=14) outnumbering males (n=11). A family history of cleft was recorded with five babies (13.9%). Associated congenital anomalies were recorded in seven (19.4%) cleft lips and/or palates. Conclusion. The incidence of 1 in 763 live births found in this study indicates that cleft lip/palate is a common congenital anomaly in Kumasi.
5
Stahl, Franka, Rosemarie Grabowski, and Katrin Wigger. "Epidemiology of Hoffmeister's “Genetically Determined Predisposition to Disturbed Development of the Dentition” in Patients with Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 43, no. 4 (July 2006): 457–65. http://dx.doi.org/10.1597/04-156.1.
Full textAbstract:
Objective Type and prevalence rates of the symptoms of Hoffmeister's “genetically determined predisposition to disturbed development of the dentition” were studied in patients with clefts. Patients Data of 263 patients with nonsyndromic clefts of lip (alveolus and palate) or isolated cleft palates were examined in a retrospective study. Setting The clefts were classified as cleft lip or cleft lip and alveolus, cleft palate, unilateral cleft lip and palate, and bilateral cleft lip and palate. All patients were scrutinized for 28 individual symptoms. Prevalences of the individual symptoms were statistically evaluated regarding cleft type and gender by using the chi-square test and were also compared with findings in patients without clefts. Results In 97.7% of the patients with clefts, at least one symptom was found. Microdontia of individual teeth, hypodontia, and hyperodontia were the symptoms most frequently recorded. Comparison of the different cleft types revealed differences regarding the prevalences of supernumerary lateral incisors (p = .051), infraposition of deciduous molars (p < .001), and atypical tooth bud position (p = .030). Comparison of the prevalences of 10 symptoms recorded in the patients with clefts with the prevalences recorded in patients without clefts showed nine symptoms were found much more frequently in the population with clefts. Conclusion These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.
6
Ortiz-Posadas, M. R., L. Vega-Alvarado, and J. Maya-Behar. "A New Approach to Classify Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 38, no. 6 (November 2001): 545–50. http://dx.doi.org/10.1597/1545-1569_2001_038_0545_anatcc_2.0.co_2.
Full textAbstract:
Objective: To propose a new method, which allows for a complete description of primary and secondary cleft palates, incorporating elements that are related to the palate, lip, and nose that will also reflect the complexity of this problem. Method: To describe the type of cleft, two embryonic structures were considered: (1) the primary palate, formed by the prolabium, premaxilla, and columella and (2) the secondary palate, which begins at the incisive foramen and is formed by a horizontal portion of the maxilla, the horizontal portion of the palatine bones, and the soft palate. Anatomical characteristics to be considered were defined, and a new method is proposed to more fully describe any cleft. Results: A description of five cases was made using the method proposed in this work and compared with other published methods for the classification and description of clefts. Conclusions: A mathematical expression was developed to characterize clefts of the primary palate, including the magnitude of palatal segment separation and the added complexity of bilateral clefts, yielding a numerical score that reflects overall complexity of the cleft. Clefts of the secondary palate are also considered in a separate score. Using this method, it is possible to incorporate elements that are not considered in other approaches and to describe all possible clefts that may exist.
7
Forrester, Mathias B., and Ruth D. Merz. "Structural Birth Defects Associated with Oral Clefts in Hawaii, 1986 to 2001." Cleft Palate-Craniofacial Journal 43, no. 3 (May 2006): 356–62. http://dx.doi.org/10.1597/04-190.1.
Full textAbstract:
Objective To identify structural birth defects that occur in association with oral clefts. Methods Data were obtained from a birth defects registry and included all infants and fetuses with cleft palate without cleft lip or cleft lip with or without cleft palate delivered from 1986 to 2001. For 47 specific structural birth defects, rates among oral cleft cases were compared with the rates among all infants and fetuses with major birth defects, excluding those with oral clefts. Results Among cleft palate only cases, the rates were significantly higher than expected for encephalocele, microcephaly, and syndactyly. Among cases of cleft lip with or without cleft palate, the rates were significantly higher than expected for anophthalmia/microphthalmia, single ventricle, reduction deformity of upper limbs, and reduction deformity of lower limbs. When cases of cleft palate only and cleft lip with or without cleft palate were compared as to the rates for particular birth defects, the rates of the defects were either higher or lower than expected in both oral cleft categories for 38 (81%) of the defects. Conclusions Certain birth defects were more frequently associated with oral clefts than might be expected. For the majority of defects, their patterns of association were similar between cleft palate without cleft lip and cleft lip with or without cleft palate.
8
Corcoran, Mirjami, Saujanya Karki, Leena Ylikontiola, Riitta Lithovius, George K. Sándor, and Virpi Harila. "Maxillary Arch Dimensions in 6-Year-Old Cleft Children in Northern Finland: A Cross-Sectional Study." International Journal of Environmental Research and Public Health 18, no. 14 (July 12, 2021): 7432. http://dx.doi.org/10.3390/ijerph18147432.
Full textAbstract:
The aim was to cross-sectionally examine the maxillary arch dimensions in 6-year-old children with cleft lip and/or palate and to compare them with the initial cleft sizes among patients with cleft palate. The study included 89 patients with clefts treated at the Oulu University Hospital. The subjects were divided into three groups: cleft palate, cleft lip, and cleft lip and palate. Study casts were scanned, and the maxillary arch dimensions were examined using a 3D program (3Shape Orthoanalyzer, Copenhagen, Denmark). The statistical methods Student’s t-test and one-way ANOVA were used to compare the means (SD) between the groups. Spearman’s correlation coefficient was used to determine the correlation between cleft severity and maxillary dimensions. A significant difference was found between different initial cleft sizes in terms of distance between the second deciduous molar and the first incisor on the right side. The intermolar width showed a negative correlation with the initial cleft size. The dimensions were shorter for clefts affecting the palate and largest for clefts affecting only the lip. Larger clefts resulted in a shorter maxilla on the right side. Many dimensions became shorter when the initial cleft was larger. Clefts of the palate resulted in smaller maxillas.
9
Kulesa-Mrowiecka, Małgorzata, Anna Lipowicz, Bożena Anna Marszałek-Kruk, Damian Kania, Wojciech Wolański, Andrzej Myśliwiec, and Krzysztof Dowgierd. "Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review." Children 11, no. 4 (March 28, 2024): 399. http://dx.doi.org/10.3390/children11040399.
Full textAbstract:
Introduction: Cleft lip with or without cleft palate (CL/P) stands as the most common congenital facial anomaly, stemming from multifactorial causes. Objective: Our study aimed to ascertain the prevalence and characteristics of cleft palates, identify associated risk factors to inform prevention and prenatal detection for early intervention, and assess postoperative rehabilitation protocols for cleft palates. Design: This study employs a retrospective descriptive and clinical approach. Patients: The study includes 103 children with cleft palates treated at the Department of Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury. Methods: We conducted a thorough evaluation of records, considering variables such as sex, cleft type, maternal occupation, parental education, and family history of clefts. Data analysis was carried out using R software version GPL-3 and ordinal logistic regression analyses. Results: Notably, children born to mothers who experienced significant stress during pregnancy exhibited a 9.4-fold increase in the odds of having bilateral cleft palates. Conversely, no substantial evidence was found to support the influence of the child’s sex, birth order, body mass, maternal exposure to workplace toxins, infections, or drug toxicity on the dependent variable. Conclusions: Our findings suggest that children with parents who have a history of clefts and those with less educated mothers are more likely to develop bilateral cleft palates. Additionally, children born to mothers experiencing stress during pregnancy face an increased risk of bilateral cleft palates. It is important to note that there is a paucity of literature on rehabilitation following various cleft palate surgical techniques in children.
10
Zubair Ahmed Abbasi, Syeda Arzoo Azeem, Shazia Sarwat Iqbal, Syed Mahmood Shah, and Zafar Abbas. "An Assessment of Pattern of Distribution of Cleft Lip and Palate Patients Reported to A Tertiary Care Hospital in Karachi, A Retrospective Study." ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE 26, no. 4 (December 31, 2021): 212–16. http://dx.doi.org/10.58397/ashkmdc.v26i4.440.
Full textAbstract:
Abstract
Objective:
To evaluate the patterns of cleft lip and palate by its type, side, gender, laterality and extent of involvement of hard and/or soft palate in patients reported to a tertiary care hospital in Karachi.
Methods:
This retrospective study was conducted from January 2016 to January 2017 at Saifee hospital Karachi. It includes patient’s data from December 2014 till December 2015. Total 198 patients with diagnosed cleft lip and /palate anomaly were included in the study. Data was collected by patient record forms and relevant findings were recorded on a predesigned proforma. Data was tabulated and analyzed using SPSS 17.00.
Results:
Out of 198 patients 117 patients were males (59%). Total 54(27.27%)) cases of isolated cleft lip were observed, isolated cleft palate cases were 34(17.17%) while mixed cleft lip and palate cases were 110 (55.55%). Out of 54 cases of isolated cleft lip 43(79.62%) cases were unilateral, in which 26(48.14%) were left sided and 17(31.48%) were right sided while 11 (20.37%) cases were bilateral. Among mixed cleft lip and palate patients 82(74.54%) were unilateral having 48(43.63%) left sided and 34(31%) were right sided while 28(25.45%) were identified as bilateral. Total unilateral cases were 125(63.13%). Total left sided cases were 74 (37.37%) and right sided were 51(25.75%). Total bilateral cases were 39(19.69%). Cases of isolated cleft palate were divided into mix hard and soft palate cleft which were 21(61.76%) while soft palate clefts were 13(38.23%).
Conclusion: I the clefts of mixed lip and palate was most common type, unilateral cleft lip and clefts of left side of both lip and palate comprised of major segment of cleft patients and incomplete clefts of both lip and palate are more common in terms of extent in a tertiary care hospital of Karachi.
Key words: Cleft Lip Palate, Tertiary Care, .
11
Inoue, Hiroki, Shuji Kayano, Yoko Aoki, Shigeo Kure, Atsushi Yamada, Akira Hata, Yoichi Matsubara, and Yoichi Suzuki. "Association of the GABRB3 Gene with Nonsyndromic Oral Clefts." Cleft Palate-Craniofacial Journal 45, no. 3 (May 2008): 261–66. http://dx.doi.org/10.1597/06-142.
Full textAbstract:
Objective: Nonsyndromic oral clefts are common craniofacial anomalies classified into two subgroups: cleft lip with or without cleft palate and isolated cleft palate. Nonsyndromic oral clefts are multifactorial diseases, with both genetic and environmental factors involved in their pathogenesis. The inhibitory neurotransmitter, γ-aminobutyric acid plays a role in normal embryonic, and particularly facial, development and γ-aminobutyric acid receptor type A β-3 subunit (GABRB3) knockout mice have been shown to have cleft palate. The GABRB3 gene is therefore a strong candidate gene for nonsyndromic oral clefts. We investigated here whether genetic variations of the GABRB3 gene affect the risk for nonsyndromic oral clefts. Method: In this case-control study, a total of 178 Japanese patients with cleft lip with or without cleft palate and 374 unrelated controls were recruited and were genotyped for six single nucleotide polymorphisms and a dinucleotide repeat marker of the GABRB3 gene. Results: None of the single nucleotide polymorphisms showed complete linkage disequilibrium with other single nucleotide polymorphisms. In a case-control association study with the six-locus haplotype of the gene, TGTGCT haplotype frequency in patients with cleft lip with or without cleft palate was significantly higher than in the controls (corrected p value = .029). None of the alleles of the dinucleotide repeat marker showed significant association with cleft lip with or without cleft palate. Conclusions: Our data suggest that the GABRB3 gene is involved in the pathogenesis of cleft lip with or without cleft palate in the Japanese population.
12
Kalisya, Luc Malemo, Jacques Fadhili Bake, Bake Elisee, Kavira Nyavandu, Robert Perry, David H. Rothstein, and Sarah B. Cairo. "Surgical Repair of Orofacial Clefts in North Kivu Province of Eastern Democratic Republic of Congo (DRC)." Cleft Palate-Craniofacial Journal 57, no. 11 (August 13, 2020): 1314–19. http://dx.doi.org/10.1177/1055665620947604.
Full textAbstract:
Background: There is a high prevalence of orofacial clefts in low- and middle-income countries with significant unmet need, despite having 50% of the population younger than 18 years in countries such as the Democratic Republic of Congo (DRC). The purpose of this article is to report on the experience of general surgeons with orofacial clefts at a single institution. Methods: This is a retrospective study of patients treated for cleft lip/palate in the province of North Kivu, DRC between 2008 and 2017. Results: A total of 1112 procedures (122/year) were performed. All procedures were performed by general surgeons following training by an international nongovernmental aid organization. A total of 59.2% of patients were male and the median age was 3.4 years (interquartile range: 0.7-13 years). Average distance from surgical center to patient location was 242.6 km (range: 2-1375 km) with outreach performed for distances >200 kms. A majority (82.1%) of patients received general anesthesia (GA) with significant differences in use of GA, age, weight, and length of stay by major orofacial cleft category. Of the 1112 patients, 86.1% were reported to have cleft lip alone, 10.5% had cleft lip and palate, and 3.4% cleft palate alone. Despite this, only 5.3% of patients underwent surgical repair of cleft palate. Conclusions: Multiple factors including malnutrition, risk of bleeding, procedural complexity, and cosmetic results may contribute to the distribution of procedures performed where most cleft palates are not treated. Based on previously published estimates, unmet needs and social burden of cleft lip and palate are high in the DRC.
13
Nouri, Dr Muyesser Abdulkarem, Dr Shehab Ahmed Hamad, and Dr Nazdar Ezzaddin Rasheed. "Incidence of Cleft Lip and Palate in Erbil City." Mustansiria Dental Journal 7, no. 1 (March 19, 2018): 106–12. http://dx.doi.org/10.32828/mdj.v7i1.383.
Full textAbstract:
Aims: This study was conducted to assess the epidemiology and some of the possiblerisk factors causing cleft lip and palate in Erbil city.Materials and Methods: the data were obtained from the records of Raparinpaediatric and maternity hospital in the center of Erbil city. The file records oflive births during a period from January 2000 to January 2008 were reviewed forthe occurrence of cleft lip and palate. The cleft cases were evaluated for site andtype of cleft and sex of the infant. and some risk factors.Results: 121 cleft lip and/or palate cases out of 60418 live births were registered. Theoverall incidence was 2:1000 live births. The percentage of cleft lip and palate,cleft palate only, cleft lip only was 55%, 30%, and 15% respectively. The ratioswith respect of left or right or bilateral cleft was approximately 4.5:2:1.The infantsex and site of family residence showed no significant influence on the incidenceof clefting. Maternal age of more than 30 years, maternal smoking, and positivefamily history of clefts, consanguineous marriage and low infant birth weightsignificantly increased the incidence of cleft lip and palate. About 7.4% of cleftcases were associated with other congenital anomalies, most frequentlycongenital heart disease.Conclusion: The incidence of cleft lip and/or cleft palate is 2:1000 births. Theincidence of cleft lip and palate is two times greater than cleft palate alone, andthree times than cleft lip alone. Cleft lip was two times greater on the left sidethan on the right side. The incidence of clefts was greater in males than females.
14
Wongsirichat, Nattharin, Basel Mahardawi, Montien Manosudprasit, Aggasit Manosudprasit, and Natthamet Wongsirichat. "The Prevalence of Cleft Lip and Palate and Their Effect on Growth and Development: A Narrative Review." Siriraj Medical Journal 74, no. 11 (November 1, 2022): 819–27. http://dx.doi.org/10.33192/smj.2022.96.
Full textAbstract:
Cleft lip and/or cleft palate (CL±P) in addition to the cleft palate (CP) are a category of anomalies known as orofacial clefts (OC). These anomalies are accompanied by several aesthetic and functional problems. Information on the prevalence of OC showed different values between studies worldwide. In addition, the presence of cleft lip and/or cleft palate is determined by several changes during the embryonic stage. Besides, cleft repair may lead to a significant impact on the overall aesthetic and function and could negatively affect maxillary growth on certain occasions. Therefore, having the background and knowledge on this phenomenon is essential in designing the overall treatment and obtaining outcomes that are as close to normal as possible. This article reviews the maxillary development, occurrence of cleft lip and/or palate and their prevalence, facial growth in the presence of clefts, effect of cleft repair, an overview of alveolar cleft treatment, as well as the essential information related the prevention of cleft lip and palate.
15
Khatun, Sanzida. "Study of Cleft Lip and Palate in Kathmandu Model Hospital, Nepal." Orthodontic Journal of Nepal 9, no. 1 (September 20, 2019): 6–10. http://dx.doi.org/10.3126/ojn.v9i1.25682.
Full textAbstract:
Introduction: Cleft lip and/or palate is a congenitally persistent space affecting orofacial region. It is generally divided into cleft lip (CL), cleft palate (CP) and cleft lip with cleft palate (CLP). The objective of the study was to evaluate distribution of patterns of orofacial clefts according to sex and laterality; predisposing factors and other congenital anomalies associated with cleft lip and/or palate.
Materials & Method: A cross-sectional descriptive type of study was carried out using in 268 patients having cleft lip and/or palate. Types of clefts, predominance of sex and laterality, familial history, associated anomalies and drug and disease history of mother were recorded.
Result: The results revealed 23.51% CL, 54.85% CLP and 21.64% CP. There were 58.21% males and 41.79% females. Positive family history of cleft was present in 28.0% and associated anomalies were observed in 3.7% of the cleft subjects. Mothers of 6.0% of the total patients were exposed to teratogenic agents during first trimester of pregnancy.
Conclusion: It was concluded that among the three types of cleft (CL, CP and CLP), CLP is the most common type. The males are affected more with cleft lip and/or palate than the females. Clefts also have risks of associated congenital anomalies. Exposure to teratogenic agents in first trimester of pregnancy is also associated with orofacial cleft.
16
Basavannaiah, Sphoorthi. "Devil’s bite in an adult woman: Unheeded & overlooked." IP Journal of Otorhinolaryngology and Allied Science 5, no. 1 (April 15, 2022): 21–23. http://dx.doi.org/10.18231/j.ijoas.2022.006.
Full textAbstract:
Cleft lip and cleft palate are birth defects that occur when a baby’s lip or mouth does not form properly during pregnancy. Together, these birth defects are commonly called “Oro-facial clefts”. Cleft palate alone can often have problems with feed, speech & hearing and problems with teeth development. The causes of these clefts among most infants are unknown. Cleft lip and cleft palate in a child are thought to be caused by a combination of genes and other factors during their gestational development.
17
Kilpeläinen, Pauli V. J., Maija T. Laine-Alava, and Seppo Lammi. "Palatal Morphology and Type of Clefting." Cleft Palate-Craniofacial Journal 33, no. 6 (November 1996): 477–82. http://dx.doi.org/10.1597/1545-1569_1996_033_0477_pmatoc_2.3.co_2.
Full textAbstract:
In this study, the variation in palatal dimensions, particularly for height, width, and depth, were evaluated in subjects with different types of cleft palate using the moiré technique. The sample consisted of 95 subjects with cleft palate and 68 noncleft individuals. Effects of cleft type, gender, developmental stage of the dentition, missing teeth, and 11 skeletal and pharyngeal cephalometric variables on palatal dimensions were assessed using multiple-regression analyses. The typing of clefts had an effect on the all palatal dimensions. The palate was shallower in subjects with clefts involving the secondary palate than in other types of clefts or in none left individuals. The palatal width was decreased in subjects with cleft in the primary palate, and the palatal depth was affected by all cleft types except submucous cleft. Gender, developmental stage of the dentition, missing teeth, and some of the cephalometric variables also had a certain effect on the palatal dimensions.
18
da Silva Filho, Omar Gabriel, Milton Santamaria, Gisele da Silva Dalben, and Gunvor Semb. "Prevalence of a Simonart's Band in Patients with Complete Cleft Lip and Alveolus and Complete Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 43, no. 4 (July 2006): 442–45. http://dx.doi.org/10.1597/05-0302.1.
Full textAbstract:
Objective To investigate the prevalence of the presence of a soft tissue bridge (Simonart's band) in patients with complete cleft lip and alveolus and complete cleft lip and palate. Design Cross-sectional. Sample We assessed 407 consecutive unoperated patients first attending the Hospital for Rehabilitation of Craniofacial Anomalies of University of São Paulo, in Bauru, São Paulo, Brazil, in the year 2000. The patients were classified as presenting complete cleft of the primary palate or of the primary and secondary palate, unilateral or bilateral, as follows: unilateral cleft lip, bilateral cleft lip, unilateral cleft lip and palate, and bilateral cleft lip and palate. Method Clinical examination. The band was considered as present whenever there was a soft tissue bridge between the separated alveolar ridges, regardless of volume and position. Results were analyzed by descriptive statistics and were expressed as percentages, according to the type of cleft. Conclusion 31.2% of patients presented with Simonart's band. The band was observed more frequently in patients with unilateral clefts than in patients with bilateral clefts, and in patients with complete cleft lip and alveolus than in patients with complete cleft lip and palate.
19
Riana A, Ruby. "DISTRIBUSI SUMBING BIBIR DAN LANGIT-LANGIT DI CLEFT LIP AND PALATE CENTER FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH MALANG INDONESIA." Saintika Medika 11, no. 2 (March 22, 2017): 76. http://dx.doi.org/10.22219/sm.v11i2.4200.
Full textAbstract:
Objective: The purpose of this study was to investigate the distribution of different cleft pattern by the age of first operation, sex, side of cleft of Cleft Lips (CL), cleft palate (CP) and cleft lip and palate patients (CLP), and education level parents in Cleft Lip and Palate Center in Faculty of Medicine, University of Malang Muhammadiyah (CLPC FM UMM). Study design: Four hundred twenty-nine patients attending the CLPC FM UMM from January 2014 to December 2016 were studied. Most patients came from East Java, Indonesia and the surrounding areas. Result: Highest frequency of CL in CLPC FM UMM is in the age group 0-1 y.o, CP patients in the age group 1-5 y.o , while most CLP patients in the age group 1-5 y.o. Cleft lip and palate (61.31%) was most frequently found, followed by cleft lip with or without alveolus (33.33%) and cleft palate (5.36%). Cleft lip and palate, cleft lip with or without alveolus and cleft palate occurred more frequently in males. Left-sided unilateral clefts were observed in 57.34% of patients compared to right-sided unilateral clefts in 21.21%, the rest is bilateral cleft 21.45%. The unilateral complete CLP (45.22%) was most frequently found, followed by the unilateral incomplete CL (18.41%). Most of the parent’s education were elementary school graduated.Conclusion: The most frequent profile in the affected population were males, left sided unilateral complete CLP were most affected.
20
Melo Filho, Mario Rodrigues, Verônica Oliveira Dias, Daniella Reis Martelli, Lívia Ribeiro Paranaíba, Mário Sérgio Oliveira Swerts, Letízia Monteiro De Barros, and Hercílio Martelli Júnior. "Tooth malposition in patients with cleft lip and/or palate in a Brazilian population." Dentistry 3000 3, no. 1 (October 23, 2015): 32–37. http://dx.doi.org/10.5195/d3000.2015.38.
Full textAbstract:
The purpose of the present study was to evaluate the prevalence of teeth malposition (rotated) in Brazilian patients with oral clefts and to contribute to the definition of subphenotypes. This study included 317 patients with nonsyndromic cleft lip with or without cleft palate. Tooth malposition was assessed clinically, through radiographs, and medical history records for each individual. Only teeth malpositions outside the area of the clefts were included. Comparisons were assessed by cross-tabulation and standard chi-square test, and statistical significance was set at p≤0.05. Cleft lip and palate was more prevalent in males, while cleft palate was more common in females. Regarding the presence of tooth malposition, of the 317 patients, 92 (29.02%) had at least one tooth with the dental anomaly. Tooth malposition was more common in patients with cleft lip and palate (16.1%), followed by, respectively, cleft palate (6.9%) and cleft lip (6%) (p=0.112). The highest occurrence of tooth malposition was in the mandible and involved the canines (p<0.01). Few studies have investigated the prevalence of tooth malposition in individuals with nonsyndromic cleft lip with or without cleft palate. Our results confirmed the highest occurrence of dental anomalies, particularly tooth malposition, in patients with oral clefts. Our findings also highlight that there was a higher occurrence of this condition in the mandible and not the maxilla.
21
Cooper, Margaret E., Jessica S. Ratay, and Mary L. Marazita. "Asian Oral-Facial Cleft Birth Prevalence." Cleft Palate-Craniofacial Journal 43, no. 5 (September 2006): 580–89. http://dx.doi.org/10.1597/05-167.
Full textAbstract:
Objective: To determine the clefting birth prevalence among Asian populations, specifically Chinese and Japanese, using raw counts from nonoverlapping published studies of Asian populations, and to investigate whether Asian clefting rates have been interpreted accurately as being up to twice the Caucasian rate. Design: A literature review of articles giving raw counts of clefting in Asian populations, primarily Japanese and Chinese. Main Outcome Measures: Where possible, clefts were identified by the patients’ ethnicity, country of origin, cleft type, syndromic status, and birth status. Results: Prevalence rates of cleft lip with or without cleft palate per 1000 live births are reported. Syndromic plus nonsyndromic cleft lip with or without cleft palate: Chinese, 1.30; Japanese, 1.34; Other Asian, 1.47; and total, 1.33. Nonsyndromic cleft lip with or without cleft palate: Chinese, 1.20; Japanese, 1.18; Other Asian, 1.22; and total, 1.19. Conclusions: Overall, Chinese and Japanese live birth prevalence rates for nonsyndromic cleft lip with or without cleft palate, based on the published reports of birth prevalence, are significantly lower than the oft-quoted rate of 2 per 1000 for Asians. The apparent reason for the discrepancy is that many published prevalence rates included all pregnancies (live births plus pregnancy losses) and do not distinguish between syndromic and nonsyndromic clefts or between cleft palate alone and cleft lip with or without cleft palate. These results demonstrate that it is extremely important for current population-based studies of clefts to include careful delineation of population groups, syndromes, cleft type, and birth status.
22
Gregg, Terry, Dorothy Boyd, and Andrew Richardson. "The Incidence of Cleft Lip and Palate in Northern Ireland from 1980–1990." British Journal of Orthodontics 21, no. 4 (November 1994): 387–92. http://dx.doi.org/10.1179/bjo.21.4.387.
Full textAbstract:
This study reports the incidence of the various types of cleft lip and/or palate drawn from a regional database of all affected children born in Northern Ireland during the period 1980–1990. The incidence of these anomalies was 1·28 per 1000 live births (1:781). Fifty-three per cent of clefts involved the secondary palate only, 16 per cent the primary palate only, 26 per cent involved both primary and secondary palate, and 5 per cent were unconnected. Overall, more males than females were affected and there were more males than females in the group having complete clefts. Separate clefts of lip and palate occurred exclusively in males with only one exception. Unilateral clefts were more common on the left side. Within the group showing complete unilateral cleft of the primary and secondary palate, left-sided clefts were more commonly male, right-sided clefts were more commonly female. There were no statistically significant sex differences between sides in the unilateral primary palate cleft group.
23
Zhu, Wan Chun, Jin Xiao, Yuan Liu, Jun Wu, and JiYao Li. "Caries Experience in Individuals with Cleft Lip and/or Palate in China." Cleft Palate-Craniofacial Journal 47, no. 1 (January 2010): 43–47. http://dx.doi.org/10.1597/07-076.1.
Full textAbstract:
Objective To determine the levels of dental caries in subjects with cleft lip and/or palate in China in comparison with controls. Design A total of 380 subjects with cleft lip and/or palate and 339 noncleft control subjects were examined for dental caries using the decayed-missing-filled-teeth (DMFT/dmft) and decayed-missing-filled-surfaces (DMFS/dmfs) index. A questionnaire was used to acquire subjects' living habits and family socioeconomic status. Setting West China Stomatology Hospital, Sichuan University. Subjects Individuals between 3 and 25 years of age. Results Caries prevalence and scores for dmft/DMFT and dmfs/DMFS were significantly higher in subjects with cleft palates when compared with the noncleft control group ( p < .05), except 3- to 5-year-old children ( p > .05). However, in the 3- to 5-year-old group, children with cleft lip and/or palate had significantly more caries than children of the same age with only a cleft lip with or without alveolus ( p < .05). Children whose clefts had been surgically repaired had a lower dmft and dmfs than those whose clefts had not been surgically repaired ( p < .05). Conclusion Individuals with oral cleft are at an increased risk for dental caries. The types of cleft and the surgical repair are two important factors for dental caries.
24
Lohmander-Agerskov, Anette, Ewa Söderpalm, Hans Friede, Eva-Carin Persson, and Jan Lilja. "Pre-Speech in Children with Cleft Lip and Palate or Cleft Palate Only: Phonetic Analysis Related to Morphologic and Functional Factors." Cleft Palate-Craniofacial Journal 31, no. 4 (July 1994): 271–79. http://dx.doi.org/10.1597/1545-1569_1994_031_0271_psicwc_2.3.co_2.
Full textAbstract:
Pre-speech in 35 children with clefts of the lip and palate or palate only were analyzed for place and manner of articulation. Transcriptions were made from tape recorded babbling sequences. Two children without clefts were used as reference. All of the children with clefts were treated according to a regimen of early surgical repair of the velum cleft and delayed closure of the cleft in the hard palate. The frequency of selected phonetic features was calculated. Correlations between phonetic/perceptual and functional and morphological factors were tested. Supraglottal articulation dominated among all the children Indicating a sufficient velopharyngeal mechanism. The results also showed correlations between cleft type and place of articulation. Anteriorly placed sounds (I.e., bilabial, dental, and alveolar sounds) occurred frequently among the children with cleft palate only and in the noncleft children. In children with cleft lip and palate, posteriorly placed articulations predominated. It was postulated that early intervention may have a positive effect on articulatory development.
25
Freitas, José Alberto de Souza, Gisele da Silva Dalben, Milton Santamaria Júnior, and Patrícia Zambonato Freitas. "Current data on the characterization of oral clefts in Brazil." Brazilian Oral Research 18, no. 2 (June 2004): 128–33. http://dx.doi.org/10.1590/s1806-83242004000200007.
Full textAbstract:
This study aimed at investigating the current distribution of the several types of clefts among the patients receiving treatment at the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC-USP), Bauru, Brazil, for the first time during the year 2000. A total of 803 unoperated patients with cleft lip and/or palate, with or without additional malformations, with no recognizable syndromes, who came to the HRAC-USP for enrollment for treatment during the year 2000. A predominance of complete cleft lip and palate, either unilateral or bilateral, was observed (37.1%), followed by isolated cleft palate (31.7%) and isolated cleft lip (28.4%). A discrete relationship between cleft palate and the female gender was noticed (53%), and males were more affected by the other types of clefts (around 60%). The findings revealed a predominance of complete clefts of the primary and secondary palate, the treatment of which is more complex, and whose frequency is greater in males.
26
Vacher, Christian, Bernard Pavy, and Jeffrey Ascherman. "Musculature of the Soft Palate: Clinico-anatomic Correlations and Therapeutic Implications in the Treatment of Cleft Palates." Cleft Palate-Craniofacial Journal 34, no. 3 (May 1997): 189–94. http://dx.doi.org/10.1597/1545-1569_1997_034_0189_motspc_2.3.co_2.
Full textAbstract:
Objective Hypoptasia of the maxilla, often described as a classic sequela to surgical repair of the cleft palate, has been rare In our experience. We believe that our surgical technique, which includes dividing the nasal mucosa and the abnormal muscular insertions at the posterior border of the hard palate, is an important factor in preventing this sequela. Method We compared the anatomy of 12 normal palates in cadavers to the anatomy of cleft palates seen at operation and to the anatomy of one cleft palate in a fetus aged 34 weeks. Results In cleft palates, the muscular fibers have an abnormal sagittal orientation, inserting on the posterior border of the hard palate. Conclusion The division of both the nasal mucosa and these abnormal muscular insertions at the posterior border of the hard palate enables the surgeon to eliminate the abnormal posterior pull of these fibers on the maxilla.
27
Demeer, Bénédicte, Nicole Revencu, Raphael Helaers, Cica Gbaguidi, Stéphanie Dakpe, Geneviève François, Bernard Devauchelle, Bénédicte Bayet, and Miikka Vikkula. "Likely Pathogenic Variants in One Third of Non-Syndromic Discontinuous Cleft Lip and Palate Patients." Genes 10, no. 10 (October 22, 2019): 833. http://dx.doi.org/10.3390/genes10100833.
Full textAbstract:
Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called discontinuous cleft. Although this phenotype may represent 5% of clefts of the lip and/or palate (CLP), it is rarely specifically referred to and its pathophysiology is unknown. We conducted whole exome sequencing (WES) and apply a candidate gene approach to non-syndromic discontinuous CLP individuals in order to identify genes and deleterious variants that could underlie this phenotype. We discovered loss-of-function variants in two out of the seven individuals, implicating FGFR1 and DLG1 genes, which represents almost one third of this cohort. Whole exome sequencing of clinically well-defined subgroups of CLP, such as discontinuous cleft, is a relevant approach to study CLP etiopathogenesis. It could facilitate more accurate clinical, epidemiological and fundamental research, ultimately resulting in better diagnosis and care of CLP patients. Non-syndromic discontinuous cleft lip and palate seems to have a strong genetic basis.
28
Mäenpää, Pia, Marja Laasonen, Marja-Leena Haapanen, Joonas Pulkkinen, and Veijo Virsu. "Crossmodal Temporal Processing Acuity in Children with Oral Clefts." Cleft Palate-Craniofacial Journal 45, no. 4 (July 2008): 393–98. http://dx.doi.org/10.1597/07-050.1.
Full textAbstract:
Objective: We have previously found that, in children with certain oral clefts, the rate of sequential information processing is significantly impaired in vision and tactile somatosensation but not so clearly in audition. Here, we studied crossmodal functions by investigating temporal processing acuity of cleft children with audiovisual, audiotactile, and visuotactile tasks. Participants: Temporal processing acuity was studied in 10-year-old children, 19 with cleft lip with or without cleft palate and 38 with cleft palate or submucous cleft palate. Design: Children estimated whether brief stimuli of two concurrent three-stimulus sequences, each in a different modality, were simultaneous or not when the stimulus interval varied adaptively. The 8-millisecond stimuli were flashes in vision, tone bursts in audition, and solenoid touches of a finger in somatosensation. Results: The group with cleft lip with or without cleft palate performed better than the group with cleft palate or submucous cleft palate in audiovisual temporal processing acuity, but the group's superiority was not statistically significant in audiotactile or visuotactile temporal processing acuity. Conclusions: Audiovisual crossmodal sequential information processing is probably impaired in some cleft children in the group with cleft palate or submucous cleft palate. Our results suggest further studies on the audiovisual capacities of children with cleft.
29
Jaruratanasirikul, Somchit, Vichai Chichareon, Nuria Pattanapreechawong, and Pasuree Sangsupavanich. "Cleft Lip and/or Palate: 10 Years Experience at a Pediatric Cleft Center in Southern Thailand." Cleft Palate-Craniofacial Journal 45, no. 6 (November 2008): 597–602. http://dx.doi.org/10.1597/07-176.1.
Full textAbstract:
Objective: To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand. Design: Retrospective, hospital-based study. Setting: Cleft Clinic Center, Songklanagarind Hospital Participants: Children with cleft lip and/or palate who were born or seen at Songklanagarind Hospital between January 1997 and December 2006. Main Outcome Measure: Clinical features including demographic data, types of cleft, associated anomalies, family history of clefts, and physical growth. Results: A total of 153 children were seen during the studied period, of whom 36 (23.5%) had isolated cleft lip, 32 (20.9%) had isolated cleft palate, and 85 (55.6%) had combined cleft lip and palate. Twenty-seven children (17.7%) had a family history of clefts. Congenital malformations (syndromic cleft) were found in 20 children (13%), and chromosomal abnormalities were found in four of these (20%). There were no significant differences among the three groups (isolated cleft lip, isolated cleft palate, and combined cleft lip and palate) in maternal and paternal ages, gestational age, birth weight, family history of cleft, or associated malformations. The physical growth parameters of children with nonsyndromic cleft were the same as in the general population. Children with syndromic cleft were significantly lighter at birth and had grown up significantly shorter and lighter, with smaller head circumference. Conclusions: Chromosomal abnormalities are commonly found in children with syndromic cleft. Children with nonsyndromic cleft have normal growth; whereas, those with syndromic cleft have some degree of prenatal and postnatal growth restriction.
30
Vieira, A. R., I. M. Orioli, E. E. Castilla, M. E. Cooper, M. L. Marazita, and J. C. Murray. "MSX1 and TGFB3 Contribute to Clefting in South America." Journal of Dental Research 82, no. 4 (April 2003): 289–92. http://dx.doi.org/10.1177/154405910308200409.
Full textAbstract:
MSX1 and TGFB3 have been proposed as genes in which mutations may contribute to non-syndromic forms of oral clefts; however, an interaction between these genes has not been described. The present study attempts to detect transmission distortion of MSX1 and TGFB3 in 217 South American children from their respective mothers. With transmission disequilibrium test analysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft palate only, and all datasets combined showed evidence of association with MSX1 (p = 0.004, p = 0.037, and p = 0.001, respectively). With likelihood ratio test analysis, “cleft lip only” showed association with MSX1 (p = 0.04) and “cleft palate only” with TGFB3 (p = 0.02). A joint analysis of MSX1 and TGFB3 suggested that there may be an interaction between these two loci to increase cleft susceptibility. These results suggest that MSX1 and TGFB3 mutations make a contribution to clefts in South American populations.
31
Behal, Roobal, Asif Khan, and Ashok Utreja. "Psychological Implications in Parents of Cleft Lip and Palate Children." Dental Journal of Advance Studies 04, no. 01 (April 2016): 015–17. http://dx.doi.org/10.1055/s-0038-1672039.
Full textAbstract:
Abstract Objective: To determine quality of life of parents of children with cleft lip and palate and to compare it with parents of non cleft lip and palate children. Method: World Health Organisation Quality of Life (Bref, Field Trial version,1996) for parents of children with cleft lip and palate. Total of 40 parents were questioned, 20 were parents of CLP chidren and the other 20 were parents of non cleft children. Results: The scores of quality of life for parents of the cleft children were significantly lower than the parents of non-cleft children. Conclusion: The parents of children with clefts had a lower Quality of Life score as compared to the parents of children with no clefts.
32
Al-Fahdawi, Mahmood Abd, Mary Medhat Farid, Mona Abou El-Fotouh, and Marwa Abdelwahab El-Kassaby. "Cone-Beam Computed Tomography Analysis of the Nasopharyngeal Airway in Nonsyndromic Cleft Lip and Palate Subjects." Cleft Palate-Craniofacial Journal 54, no. 2 (March 2017): 202–9. http://dx.doi.org/10.1597/15-134.
Full textAbstract:
Objective To assess the nasopharyngeal airway volume, cross-sectional area, and depth in previously repaired nonsyndromic unilateral cleft lip and palate versus bilateral cleft lip and palate patients compared with noncleft controls using cone-beam computed tomography with the ultimate goal of finding whether cleft lip and palate patients are more liable to nasopharyngeal airway obstruction. Design A retrospective analysis comparing bilateral cleft lip and palate, unilateral cleft lip and palate, and control subjects. Significance at P ≤ .05. Setting Cleft Care Center and the outpatient clinic that are both affiliated with our faculty. Participants Cone-beam computed tomography data were selected of 58 individuals aged 9 to 12 years: 14 with bilateral cleft lip and palate and 20 with unilateral cleft lip and palate as well as 24 age- and gender-matched noncleft controls. Variables Volume, depth, and cross-sectional area of nasopharyngeal airway were measured. Results Patients with bilateral cleft lip and palate showed significantly larger nasopharyngeal airway volume than controls and patients with unilateral cleft lip and palate ( P < .001). Patients with bilateral cleft lip and palate showed significantly larger cross-sectional area than those with unilateral cleft lip and palate ( P < .001) and insignificant cross-sectional area compared with controls ( P > .05). Patients with bilateral cleft lip and palate showed significantly larger depth than controls and those with unilateral cleft lip and palate ( P < .001). Patients with unilateral cleft lip and palate showed insignificant nasopharyngeal airway volume, cross-sectional area, and depth compared with controls ( P > .05). Conclusions Unilateral and bilateral cleft lip and palate patients did not show significantly less volume, cross-sectional area, or depth of nasopharyngeal airway than controls. From the results of this study we conclude that unilateral and bilateral cleft lip and palate patients at the studied age and stage of repaired clefts are not more prone to nasopharyngeal airway obstruction than controls.
33
Mitic, Vladimir, Marina Jonovic, Nadica Mitic, Aleksandar Mitic, Dejan Mitic, Mariola Stojanovic, and Predrag Kovacevic. "Incidence of lip and palate clefts in children in Nis from 1990 to 2007." Srpski arhiv za celokupno lekarstvo 139, no. 5-6 (2011): 298–303. http://dx.doi.org/10.2298/sarh1106298m.
Full textAbstract:
Introduction. Cleft lip and palate is a complex congenital anomaly of the orofacial system in children. Objective. The aim of this study was to determine the incidence of live-born children with cleft lip and/or palate compared to the total number of children born in the period from January 1, 1990 to December 31, 2007. Methods. Epidemiological investigation was based on the records of live-born children at the Hospital of Gynaecology and Obstetrics of the Clinical Centre Nis. The study included 61,116 live-born children, i.e. 56,905 full-term babies. Results. The total number of registered clefts during the investigation period was 43 (22 boys and 21 girls). The most frequent were the secondary palate clefts (44.2%); combined clefts were present in 34.9%, while primary palate clefts were reported in 20.9%. In respect to the season and order of birth, there was no statistically significant difference in the frequency of the primary, secondary and complete palate clefts. The age of mothers was not identified as a risk factor for the occurrence of cleft lip and palate. Conclusion. In the studied period, 43 children were born with the cleft lip and/or palate, equally in boys as in girls. The secondary palate clefts were most frequent. The season and order of birth had no statistical influence on the occurrence of this anomaly.
34
Al Omari, F., and I. K. Al-Omari. "Cleft Lip and Palate in Jordan: Birth Prevalence Rate." Cleft Palate-Craniofacial Journal 41, no. 6 (November 2004): 609–12. http://dx.doi.org/10.1597/03-034.1.
Full textAbstract:
Objective and Design A retrospective investigation was conducted to determine the prevalence rate of Jordanian children born with oral clefts from 1991 to 2001. Setting Hospital surgical records from two main sources were used to identify all children born with orofacial clefting. Information about date of birth, sex, cleft types, and associated major anomalies and syndromes were recorded. Results The overall prevalence rate for live births with cleft lip, cleft palate, or both was 1.39 per 1000 live births. Thirty percent of the clefts identified affected the lip, 22 percent affected the palate, and 48 percent involved the clefts of the lip and palate. In general, higher prevalence rates were found for boys than girls (55% boys versus 45% girls). There was a statistically significant sex difference between the cleft types. Clefts of the isolated palate, however, were more common in girls. Eighteen percent of patients with cleft were associated with major anomalies or syndromes. Conclusions The reported prevalence rate for orofacial clefts among Jordanians is similar to the previously reported prevalence rate in white Caucasians. Results and future recommendations are discussed.
35
Onofre, Mirian Aparecida, Heli Benedito Brosco, and Rumio Taga. "Relationship between Lower-Lip Fistulae and Cleft Lip and/or Palate in Van der Woude Syndrome." Cleft Palate-Craniofacial Journal 34, no. 3 (May 1997): 261–65. http://dx.doi.org/10.1597/1545-1569_1997_034_0261_rbllfa_2.3.co_2.
Full textAbstract:
Objective This study was conducted to evaluate the relationship between fistulae of the lower lip and cleft lip and/or palate in patients with Van der Woude syndrome. Methods The medical records of 11,000 patients with cleft lip and/or palate registered at the Cleft Lip-Palate Research and Rehabilitation Hospital, University of São Paulo, Bauru were reviewed. Of these patients, 133 (1.2%) presented with Van der Woude syndrome. Results Of the 133 patients, 88 (66.2%) exhibited full clefts, 22 (16.5%) only cleft lip, and 23 (17.3%) only cleft palate. The lower-lip fistulae observed in these 133 patients were bilateral symmetric in 66 (49.7%), bilateral asymmetric in 42 (31.6%), microform In 19 (14.3%), median in 5 (3.8%), and unilateral in 1 (0.7%). Conclusion This population sample appears to exhibit the previously published tendency for bilateral, unilateral, or mixed-type congenital fistulae to be associated with cleft lip with or without cleft palate, while so-called microforms or conic elevations are almost exclusively associated with cleft palate.
36
Šmahel, Zbyněk, and Božena Škvařilová. "Length of the Cervical Spine as a Factor in the Etiology of Cleft Palate." Cleft Palate-Craniofacial Journal 30, no. 3 (May 1993): 274–78. http://dx.doi.org/10.1597/1545-1569_1993_030_0274_lotcsa_2.3.co_2.
Full textAbstract:
The length of the cervical spine in a series of 206 adult males with cleft lip and/or palate and 50 normal controls was measured. The patients were divided into five subgroups according to the type and extent of the cleft. The shortening of the spine was most marked in bilateral cleft lip and palate patients (complete), less marked in unilateral cleft lip and palate patients, and was slight in isolated cleft palate patients. Complete isolated cleft palate and cleft lip was not associated with a shortening of the spine. A shortening of the cervical spine in less extensive types of isolated cleft palate was suggestive of the participation of the spine in their development, while in cleft lip and palate a simultaneous exposure to a teratogenic agent or any other developmental error during early stages of embryogenesis could explain the concomitant occurrence of spine anomalies. Patients with cleft lip and palate associated with a short spine also had a shorter mandibular ramus, which could be suggestive of simultaneous damage to both structures during morphogenesis. This relationship was not demonstrated in isolated cleft palate that developed in later stages of embryogenesis. In these cases a short spine itself could not have impaired the growth potential of the mandible, yet it could have mechanically induced the development of cleft palate. These observations are in agreement with the present state of knowledge on the development of orofacial clefts as shown in experimental animals.
37
Alves, Karina Mirela Ribeiro Pinto, Virginia Peixoto, Márcia Ribeiro Gomide, Cleide Felíciode Carvalho Carrara, and Beatriz Costa. "Prevalence of Palatal and Alveolar Cysts in Babies with Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 41, no. 5 (September 2004): 490–93. http://dx.doi.org/10.1597/02-139.1.
Full textAbstract:
Objective To evaluate the prevalence of palatal and alveolar cysts in babies with cleft lip and/or palate. Design Cross-sectional. Setting Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Bauru, São Paulo, Brazil. Participants Two hundred ninety-one Caucasian babies divided into four groups according to the type of cleft: cleft lip with or without cleft alveolus (70), complete unilateral cleft lip and palate (112), complete bilateral cleft lip and palate (56), and cleft palate (53). Results A low prevalence of palatal and alveolar cysts was observed among patients with the four different types of clefts, with no statistically significant difference between genders. The maxilla and the anterior area of the mouth were more affected than the mandible and the posterior area. Conclusions The low prevalence of palatal and alveolar cysts in the four groups of babies with clefts included in this study may have been due to the high mean age of the sample.
38
Chandrasekharan, Deepak, and Arvind Ramanathan. "Identification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate." European Journal of Dentistry 08, no. 04 (October 2014): 528–32. http://dx.doi.org/10.4103/1305-7456.143637.
Full textAbstract:
ABSTRACT Objective: Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects with nonsyndromic oral clefts is not known, we designed the present study to investigate the occurrence of the above mutations in them. Materials and Methods: Total genomic DNA extracted from peripheral blood of 60 subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate, and equal number of control healthy subjects were amplified with primers flanking exon 1 of ARHGAP29 gene and subjected to direct sequencing. Results: Sequencing analysis identified a nonsense mutation in exon 1 of ARHGAP29 that caused substitution of lysine to stop codon at codon position 32 in a subject with nonsyndromic cleft lip with cleft palate. The mutation, however, occurred in heterozygous condition. None of the other subjects carried mutation in this region. Conclusion: The study has thus identified a rare but novel truncation mutation in ARHGAP29 gene for the first time in nonsyndromic oral clefts.
39
Bamborschke, Daniel, Matthias Pergande, Hülya Sevcan Daimagüler, Elisabeth Mangold, Jörg Dötsch, Peter Herkenrath, Sebahattin Cirak, and Walid Fazeli. "Cleft Palate as Distinguishing Feature in a Patient with GABRB3 Epileptic Encephalopathy." Neuropediatrics 50, no. 06 (July 18, 2019): 378–81. http://dx.doi.org/10.1055/s-0039-1693143.
Full textAbstract:
Mutations in GABAA-receptor subunit genes are associated with a heterogeneous spectrum of epilepsies. Patients with epilepsy caused by mutations in a specific GABAA-receptor (GABRA3) occasionally present with orofacial dysmorphism (e.g., cleft palates). While cleft palates have been described in Gabrb3 knockout mice and in humans with GABRB3 variants without epilepsy, the specific combination of epilepsy and cleft palate in humans with GABRB3 mutations has not yet been reported.We describe a patient with epileptic encephalopathy (EE) who presented with therapy-refractory neonatal-onset myoclonic seizures and severe developmental delay. Electroencephalogram showed burst suppression pattern at neonatal age and hypsarrhythmia at infantile age. Initial magnetic resonance imaging was unremarkable. As he additionally presented with a cleft palate, we were curious whether cleft palate and EE had the same genetic origin. Whole exome sequencing of the index patient revealed a novel pathogenic heterozygous de novo mutation in GABRB3 (c.899T > C; p.I300T). In consistency with Gabrb3 knockout mice data, this is the first report of cleft palate in a patient with GABRB3 associated EE.We suggest to add cleft palate to the phenotypic GABRB3 spectrum and to screen for mutations in GABAA-receptors in patients with EE and orofacial dysmorphism.
40
Kanth, Aditi M., Max Krevalin, and Oluwaseun A. Adetayo. "Surgical Approach to Hemipalatal Discrepancy in Tessier 7 Reconstruction: Review of Literature and Case Series." Cleft Palate-Craniofacial Journal 58, no. 9 (February 22, 2021): 1094–101. http://dx.doi.org/10.1177/1055665620984045.
Full textAbstract:
Objective: The authors present findings and techniques to address hemipalatal discrepancy in patients with Tessier 7 cleft and associated cleft palate during cleft palatoplasty. Design: The authors report 2 cases of pediatric patients with Tessier 7 facial clefts and associated cleft palate. One patient presents on the broader oculo-auriculo-vertebral spectrum and the other is has isolated Tessier cleft 7. Additionally, a PubMed search was performed using the MeSH terms “tessier 7,” “cleft palate”, “macrostomia,” “tessier 7 AND cleft palate,” “macrostomia AND cleft palate,” AND “hemipalatal discrepancy.” All relevant literature was identified and underwent full review for qualitative analysis. Results: Two patients met criteria for inclusion in this article. The surgical techniques utilized to mitigate the hemipalatal length discrepancy are detailed, and intraoperative photographs are provided. The results of the literature review are also presented. Tessier 7 craniofacial cleft and palatal clefts, when occurring in combination, is noted to result in discrepant hemipalatal length with short maxillary palate length on the affected side as well hypoplasia of the associated speech musculature. The postoperative palatal length after palatoplasty in both patients was longer than the preoperative hypoplastic palatal length. Conclusions: When occurring in combination, Tessier 7 craniofacial cleft and concomitant palatal cleft results in discrepant hemipalatal length, and deficiency of the bony maxillary palatal shelves, and associated speech musculature and soft tissues. The techniques described in this article may assist in maximizing postoperative palatal length.
41
Suslak, Lorraine, and Franklin Desposito. "Infants with Cleft Lip/Cleft Palate." Pediatrics In Review 9, no. 10 (April 1, 1988): 331–34. http://dx.doi.org/10.1542/pir.9.10.331.
Full textAbstract:
A cleft of the lip and/or palate occurs approximately once in 750 live births with some variability among various racial groups. As an isolated defect, cleft lip with or without cleft palate is etiologically distinct from cleft palate alone. More than 250 clefting syndromes, most of them relatively uncommon, have been described. In 1970, less than 3% of all cases of cleft lip and/or palate were thought to be associated with identifiable syndromes. A recent survey from a major cleft palate center in New York showed that 30% of patients had recognizable conditions. Some of these included genetic syndromes and others like the charge association or those related to environmental agents were sporadic. Another 30% of cases had one or more associated anomalies, although a specific syndromic diagnosis or etiologic basis could not be identified. The remaining 40% had isolated clefts. A summary of syndromes with cleft lip and palate by etiology is given in Table 1. Approximately, half of the recognized syndromes are due to single-gene disorders with an equal distribution among autosomal dominant and autosomal recessive inheritance. Chromosomal abnormalities account for 18% of the clefting syndromes and would invariably be associated with other malformations, delayed development, and poor prognosis.
42
Sivesh Sangar, Vignesh Ravindran, and Visalakshi Ramanathan. "Dental Caries in Children With and Without Cleft Palate: A case Control Study." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (October 19, 2020): 1494–99. http://dx.doi.org/10.26452/ijrps.v11ispl3.3459.
Full textAbstract:
The lack of knowledge about oral hygiene maintenance among the general population with oro-facial clefts would lead to a poororal health. The aim was to determine the prevalence of dental caries status in children with cleft palate only. The purpose of the study was to assess the prevalence of dental caries status in children with cleft palate only. A study was carried out by collecting data by reviewing patients’ data and analysing the data of 86000 patients between June 2019 and March 2020 at the private dental institute. The sample size that was taken included 19 children with cleft palate and 19 children without cleft palate (control), who came to the private dental institute. Results showed that the mean DMFT score for the children with cleft palate was 1.74 while the mean DMFT score in children without cleft palate was 5.84. The prevalence of dental caries was compared for both case and control group were compared by Mann-Whitney U test, which gave a result of p=0.000. Within the limitations of the present study concluded that, dental caries status in children with cleft palate is significantly less than the dental caries status in children without cleft palate.
43
Watanabe, Akira, Sadanori Akita, Nguyen Thi Duc Tin, Nagato Natsume, Yoko Nakano, Norio Niikawa, Takeshi Uchiyama, and Koh-ichiro Yoshiura. "A Mutation in RYK is a Genetic Factor for Nonsyndromic Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 43, no. 3 (May 2006): 310–16. http://dx.doi.org/10.1597/04-145.1.
Full textAbstract:
Objective The RYK, EPHB2, and EPHB3 genes are attractive candidates for cleft lip and/or palate and cleft palate only pathogenesis. Both the Ryk-deficient mouse and Ephb2/Ephb3 (genes for interaction molecules with RYK) double-mutant mouse show cleft palate. Setting Mutation searches for RYK, EPHB2, and EPHB3 were carried out in a large number of Japanese and Vietnamese patients with cleft lip and/or palate and cleft palate only. Case-control study and transmission disequilibrium tests were performed also, using three single nucleotide polymorphisms within a linkage disequilibrium block in RYK. Seven haplotypes were constructed from the single nucleotide polymorphisms. Results A missense mutation, 1355G>A (Y452C), in RYK was identified in one Vietnamese patient with cleft lip and/or palate. This mutation was not found among 1646 Vietnamese, Japanese, and Caucasians, including 354 cleft lip and/ or palate and cleft palate only patients. Colony formation assay using NIH3T3 cells transfected with mutant cDNA revealed that mutant RYK had significantly reduced protein activity, compared with those with wild-type RYK, implying that the transformation ability of RYK is depleted by this mutation. Although a case-control study and transmission disequilibrium tests on three individual single nucleotide polymorphisms provided no evidence for association with oral clefts, a case-control study on one rare haplotype suggested a positive association in Japanese patients with cleft lip and/or palate and cleft palate only. No mutations in EPHB2 and EPHB3 were found in any patients examined. Conclusion The findings suggested that a missense mutation, 1355G>A, and one rare single nucleotide polymorphisms haplotype may play a role in the development of cleft lip and/or palate in the Vietnamese, and cleft lip and/ or palate and cleft palate only in the Japanese.
44
Jones, Courtney E., Kathy L. Chapman, and Mary A. Hardin-Jones. "Speech Development of Children with Cleft Palate before and after Palatal Surgery." Cleft Palate-Craniofacial Journal 40, no. 1 (January 2003): 19–31. http://dx.doi.org/10.1597/1545-1569_2003_040_0019_sdocwc_2.0.co_2.
Full textAbstract:
Objective This study examined the speech production abilities of children with cleft palate before and after palate repair. Participants Twenty-eight children participated in the study, 14 with cleft palate and 14 without clefts matched for age, gender, and mothers’ educational level. Main Outcome Measures Comparisons were made between the children with cleft palate before and after surgery for canonical babbling ratios, size of consonant inventories, place and manner characteristics, and early developing sounds [p, b, t, d, k, g, m, n, η]. Also, comparisons were made between the children with cleft palate and their peers without clefts at postsurgery/17 months for the measures described above. Results Paired ttests revealed differences in pre- and postsurgery performance of the children with cleft palate for production of canonical syllables and size of consonant inventories. Although no significant differences were noted for place and manner features, production of oral stops doubled from the time before surgery to that after surgery. Specifically, production of the bilabial stop [b] showed significant change over time. Results of independent t tests indicated no difference between groups for production of canonical syllables and size of consonant inventories at 17 months. However, significant group differences were noted for production of stops, oral stops, nasals, glides, and alveolars. The children without clefts produced more stops, oral stops, and alveolars. In contrast, more nasals and glides were seen in the vocalizations of the children with cleft palate. Conclusions Children with cleft palate made gains in production of canonical syllables and size of consonant inventories postsurgery; however, they continued to show deficits in production of stops and alveolar place features.
45
Noor, Siti Noor Fazliah Mohd, and Sabri Musa. "Assessment of Patients’ Level of Satisfaction with Cleft Treatment Using the Cleft Evaluation Profile." Cleft Palate-Craniofacial Journal 44, no. 3 (May 2007): 292–303. http://dx.doi.org/10.1597/05-151.
Full textAbstract:
Objectives: Determination of the psychosocial status and assessment of the level of satisfaction in Malaysian cleft palate patients and their parents. Design: Cross-sectional study. Participants and Methods: Sixty cleft lip and palate patients (12 to 17 years of age) from Hospital Universiti Sains Malaysia and their parents were selected. The questionnaires used were the Child Interview Schedule, the Parents Interview Schedule, and the Cleft Evaluation Profile (CEP), administered via individual interviews. Results: Patients were teased because of their clefts and felt their self-confidence was affected by the cleft condition. They were frequently teased about cleft-related features such as speech, teeth, and lip appearance. Parents also reported that their children were being teased because of their clefts and that their children's self-confidence was affected by the clefts. Both showed a significant level of satisfaction with the treatment provided by the cleft team. There was no significant difference between the responses of the patients and their parents. The features that were found to be most important for the patients and their parents, in decreasing order of priority, were teeth, nose, lips, and speech. Conclusions: Cleft lip and/or palate patients were teased because of their clefts, and it affected their self-confidence. The Cleft Evaluation Profile is a reliable and useful tool to assess patients’ level of satisfaction with treatment received for cleft lip and/or palate and can identify the types of cleft-related features that are most important for the patients.
46
Vasil’ev, Yuriy Anatol’evich, A. N. Red’ko, O. V. Gulenko, and I. G. Udina. "PRENATAL ULTRASONIC DETECTION OF CONGENITAL CLEFTS OF LIP AND PALATE IN KRASNODARSKII KRAI." Russian Journal of Dentistry 21, no. 4 (August 15, 2017): 190–93. http://dx.doi.org/10.18821/1728-2802-2017-21-4-190-193.
Full textAbstract:
The goal of our study was investigation of prenatal diagnostics of pathology and distribution of associated anomalies in the group of children - patients of clinic with congenital maxillofacial anomalies. Basing on oral poll of mothers given birth to children with the pathology during the period 2012-2014 in Krasnodarskii krai (358 cases), the efficiency of prenatal detection of congenital clefts of lip and palate (diagnosis Q36, Q35 and Q37 by MKB-10) by ultrasonic investigation was studied. Prenatal 2D ultrasonic investigation is performed three times during pregnancy on 12, 18-24 and 32-34 weeks of pregnancy. Cleft lip or palate were detected on the second and third ultrasonic investigation: cleft palate (Q35) was revealed only in 5,6% cases of children born with cleft palate, and cleft palate (Q36 and Q37) - in 33,8% cases. Importance of prenatal ultrasonic diagnostics of pathology is not only predetermined by the necessity of mental conditioning of parents for the most urgent and proper rehabilitation of ill children, but, also, by the fact that patients with clefts of lip or palate frequently have associated pathology of other organs and chromosomal anomaly. For proper prenatal detection of cleft palate 3D ultrasonic investigation is necessary. We also studied the presence of associated pathology distribution for the cases of isolated clefts of lip or palate. Higher efficiency of cleft lip and palate detection in prenatal period by ultrasonic diagnostics would support more successful rehabilitation by well-timed mental conditioning and informing of parents about stages of rehabilitation in the process of child growing. Ethical aspects of probable abortion because of detected pathology during ultrasonic investigation.
47
Babai, Arwa, and Melita Irving. "Orofacial Clefts: Genetics of Cleft Lip and Palate." Genes 14, no. 8 (August 9, 2023): 1603. http://dx.doi.org/10.3390/genes14081603.
Full textAbstract:
Orofacial clefting is considered one of the commonest birth defects worldwide. It presents as cleft lip only, isolated cleft palate or cleft lip and palate. The condition has a diverse genetic background influenced by gene–gene and gene–environment interaction, resulting in two main types, syndromic and nonsyndromic orofacial clefts. Orofacial clefts lead to significant physiological difficulties that affect feeding, speech and language development and other developmental aspects, which results in an increased social and financial burden on the affected individuals and their families. The management of cleft lip and palate is solely based on following a multidisciplinary team approach. In this narrative review article, we briefly summarize the different genetic causes of orofacial clefts and discuss some of the common syndromes and the approach to the management of orofacial clefts.
48
Rossell-Perry, Percy. "New Diagram for Cleft Lip and Palate Description: The Clock Diagram." Cleft Palate-Craniofacial Journal 46, no. 3 (May 2009): 305–13. http://dx.doi.org/10.1597/08-070.1.
Full textAbstract:
Objectives: The current classification diagrams for cleft lip and palate are descriptions of the components involved in the cleft, but they do not consider in detail the severity of distortion. We sought to establish a new diagram (the Clock Diagram) for cleft lip and palate, which describes the pathology according to the severity of distortion of the nose, lip, and primary and secondary palate, and to apply this classification scheme toward treatment selection. Methods: The method is based on surgical results obtained from 1043 cleft lip and palate patients operated by the author between 1996 and 2007, under the protocol based on our classification. To further illustrate the classification and diagram method, two types of clefts are described, using the proposed diagram and compared with Kernahan's diagram. Results: This new diagram describes the cleft's severity using terminology from our clinic's classification of cleft severity. In comparison with Kernahan's diagram, the Clock Diagram more effectively demonstrates a cleft's severity. I have observed a higher incidence of lip and palate revision in severe clefts. Conclusions: The Outreach Program Lima Clock Diagram classifies the severity of the cleft and affords an individualized description of cleft morphology. I have observed a direct relation between cleft severity and the number of poor outcomes in our patients.
49
Wyszynski, Diego, Andrea Sarkozi, Peter Vargha, and Andrew Czeizel. "Birth weight and gestational age of newborns with cleft lip with or without cleft palate and with isolated cleft palate." Journal of Clinical Pediatric Dentistry 27, no. 2 (January 1, 2004): 185–90. http://dx.doi.org/10.17796/jcpd.27.2.475367q2601u3x4w.
Full textAbstract:
The birth weight and gestational age of 1368 newborns with isolated cleft lip with or without cleft palate and 582 with isolated cleft palate were compared to those of matched healthy controls. The results indicate that fetuses with oral clefts are at elevated risk of having low and very low birth weight, but not of having a premature birth. Speculations on a relationship between these findings and the presence of oral clefts are presented.
50
Daskalogiannakis, John, Kari L. Kuntz, Albert E. Chudley, and R. Bruce Ross. "Unilateral Cleft Lip with or without Cleft Palate and Handedness: Is There an Association?" Cleft Palate-Craniofacial Journal 35, no. 1 (January 1998): 46–51. http://dx.doi.org/10.1597/1545-1569_1998_035_0046_uclwow_2.3.co_2.
Full textAbstract:
Objective The purpose of this study was to investigate the possibility of a relationship between the side of occurrence of unilateral clefting of the lip and/or palate and handedness, also taking into account the type of the initial cleft condition, a factor that has not been adequately assessed in previous studies. Design This was a retrospective study. Setting Division of Orthodontics, The Hospital for Sick Children, Toronto, Canada, and Cleft Lip and Palate Program, Children's Hospital, Winnipeg, Canada. Participants Subjects were 289 patients (176 males and 113 females) 9 years of age or older presenting with a history of unilateral clefts of the lip with or without the palate. Of these patients, 217 were recruited from the patient pool of the Orthodontic Clinic at the Hospital for Sick Children in Toronto. The remaining 72 were selected from the registry of the Cleft Lip and Palate Program of the Children's Hospital in Winnipeg. Any syndromic cases were excluded from the sample. Main outcome Measures Assessment of handedness was performed by asking the patients to fill out a multi-item questionnaire in which patients were asked to identify which hand they would use for different tasks. The side and type of the initial cleft condition were identified by reviewing each patient's hospital chart and by cross-referencing with clinical examination. Statistical evaluation of the results was performed by using the chi-square test. Results There was a significantly larger number of left-sided clefts (198) in the sample than right-sided clefts (91), (p < .001). The proportion of left-sided clefts among left-handers (84.6%) was higher than that among right-handers (66.8%). However, the relationship between side of cleft and handedness was not statistically significant (p = .185). Clefts of the primary palate only seemed to occur on the left side 3.5 times more often than on the right, whereas the corresponding ratio of left:right manifestation for clefts of the primary and secondary palate was 1.8:1. The difference was statistically significant (p < .05). Conclusion The findings of this study confirm the affinity of unilateral clefts for the left side but suggest that there are differences between clefts of the primary palate only and clefts of the primary and secondary palate. Also, non-right-handed patients show a greater predilection for having a cleft on the left side than do right-handed patients.