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1

Parasuraman, Subramani, Ramasamy Raveendran, and Raja J. Selvaraj. "Effects of Cleistanthins A and B on Blood Pressure and Electrocardiogram in Wistar Rats." Zeitschrift für Naturforschung C 66, no. 11-12 (2011): 581–87. http://dx.doi.org/10.1515/znc-2011-11-1207.

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We have studied the effects of cleistanthin A and cleistanthin B, phytoconstituents isolated from the leaves of Cleistanthus collinus Roxb. (Euphorbiaceae), on blood pressure, electrocardiogram, and barium chloride-induced arrhythmia in Wistar rats. The two compounds were isolated by column chromatography and their identity was confirmed spectroscopically. A healthy, male Wistar rat was used to record the invasive blood pressure and electrocardiograph. The antiarrhythmic effects of cleistanthins A and B were studied using the barium chloride model. Both cleistanthin A and cleistanthin B showed
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2

Mohan, Alladi, and Janjam Harikrishna. "Cleistanthus collinus Poisoning." Indian Journal of Critical Care Medicine 23, S4 (2019): 0. http://dx.doi.org/10.5005/jp-journals-10071-23317.

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3

Chrispal, Anugrah. "Cleistanthus collinus poisoning." Journal of Emergencies, Trauma, and Shock 5, no. 2 (2012): 160. http://dx.doi.org/10.4103/0974-2700.96486.

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4

Homkar, Uday. "Virachola isocrates: A new fruit pest reported on Garari Cleistanthus collinus (Roxb.) Benth. Ex Hook.f. in Madhya Pradesh." Indian Journal of Forestry 32, no. 1 (2009): 123–26. http://dx.doi.org/10.54207/bsmps1000-2009-uuvw1d.

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Garari Cleistanthus collinus (Roxb.) Benth. ex Hook.f. is one of the important deciduous forest species in Seoni district of Madhya Pradesh. In the present study, infected fruits of C. collinus were collected and larvae in different age group were recovered. These larvae were reared in laboratory. The seed borer was identified at Entomology Division of Tropical Forest Research Institute, Jabalpur as Virachola isocrates (Lycaenidae). It attacks from June to September. This insect has been reported for the first time as insect pests on fruits and seeds of Garari (Cleistanthus collinus) it is rec
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5

Kaliyannan, Mohanambal, and G. Vijayakumar. "Intoxication of Cleistanthus collinus leaves in a Jersey Cross-Bred Cattle- A Case Report." Indian Journal of Veterinary Medicine 44, no. 2 (2024): 60–61. http://dx.doi.org/10.56093/ijvm.v44i2.159933.

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The present article reports intoxication of leaves of Cleistanthus collinus in a pleuriparous Jersey cross-bred cow. The cow was presented with lethargy, anxiety, ataxia, colic, and muscle tremors following grazing in a field with Cleistanthus collinus plant. Serum biochemistry revealed elevated liver enzymes, BUN and creatinine. Cow was administered with intravenous fluids therapy, N-acetylcysteine and oral activated charcoal. Cow died in spite of the treatment. This case underscores the need for creating awareness among farmers on plant toxicity in farm animals.
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6

Bheem Rao, Rajamani, Ramalingam S., and Narayanan.S. "A case of oduvanthalai poisoning." IP International Journal of Forensic Medicine and Toxicological Sciences 9, no. 3 (2024): 117–21. http://dx.doi.org/10.18231/j.ijfmts.2024.024.

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Cleistanthus collinus or Oduvanthalai or odukanthazhai poisoning though rare, incidences of this poison has been reported now and then. It is a very common plant poison in rural South India, with a poor outcome. Increase in age, underlying chronic diseases of kidneys and heart decides the outcome of the case. Suicidal or accidental ingestion of the plant poison causes hypokalemia, arrhythmias, metabolic acidosis, ARDS and eventually death. Death is mainly due to its alkaloid Cleistanthin A and B and oduvan.
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7

Ramesh, Chimmani, Nasi Ravindranath, Tejomoortula Siva Ram, and Biswanath Das. "Arylnaphthalide Lignans from Cleistanthus collinus." CHEMICAL & PHARMACEUTICAL BULLETIN 51, no. 11 (2003): 1299–300. http://dx.doi.org/10.1248/cpb.51.1299.

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8

Venu, P., and Gyan Chand. "Biogeochemical Studies in Some Copper Rich Areas of Singhbhum Copper Belt, Bihar, India." Journal Geological Society of India 48, no. 4 (1996): 439–47. http://dx.doi.org/10.17491/jgsi/1996/480409.

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Abstract Forty eight plant species (528 plant samples) from the Singhbhum copper belt were examined and their relationships with soil copper gradient were assessed. Syzygium cumini, Woodfordia fruticosa, Cleistanthus collinus and Buchanania lanzan are observed to grow in very high soil copper concentration maintaining remarkably moderate levels of copper in their bioparts. Results of Student's 't' test suggests that some species exhibit preferential concentration of copper in different bioparts. Copper levels estimated in Anogeissus latifolia, Butea frondosa, Cleistanthus collinus, Croton roxb
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9

Parasuraman, S., and R. Raveendran. "Diuretic Effects of Cleistanthin A and Cleistanthin B from the Leaves of Cleistanthus Collinus in Wistar Rats." Journal of Young Pharmacists 4, no. 2 (2012): 73–77. http://dx.doi.org/10.4103/0975-1483.96616.

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10

Parasuraman, Subramani, Ramasamy Raveendran, Nachiappa Ganesh Rajesh, and Subbiah Nandhakumar. "Sub-chronic toxicological evaluation of cleistanthin A and cleistanthin B from the leaves of Cleistanthus collinus (Roxb.)." Toxicology Reports 1 (2014): 596–611. http://dx.doi.org/10.1016/j.toxrep.2014.08.006.

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11

Raja, G., S. S. Kumaran, and V. P. Chandrasekeran. "Outcome of Cleistanthus Collinus Poisoning with and without Charcoal." Academic Emergency Medicine 14, no. 5 (2007): e111-e111. http://dx.doi.org/10.1197/j.aem.2007.02.010.

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12

Bompelli, Nandakishore, Rakesh Reddy C, Santosh Modani, and Anirudda Deshpande. "Cleistanthus collinus poisoning: a case report of intentional poisoning." BMJ Case Reports 12, no. 2 (2019): bcr—2018–228197. http://dx.doi.org/10.1136/bcr-2018-228197.

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We report a case of 50-year-old male patient from tribal area in South Indian state of Telangana, who ingested the liquid extract from crushed leaves of the plant, cleistanthus collinius with the intention of self-harm. Immediate gastric lavage and activated charcoal administration was done and the patient was subsequently admitted into an acute medical care unit. During first 24 hours of monitoring, the patient was clinically stable. There was mild normal anion gap metabolic acidosis and hypokalaemia on arterial blood gas (ABG) and was corrected accordingly. On second day of admission he deve
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13

Quraishi, Afaque, Vijaya Koche, and S. K. Mishra. "In vitro micropropagation from nodal segments of Cleistanthus collinus." Plant Cell, Tissue and Organ Culture 45, no. 1 (1996): 87–91. http://dx.doi.org/10.1007/bf00043433.

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14

J, Kavya, Molakala Pavan Kumar Reddy, Addapu Dharaneedhar, Goutham G, M. Mythreyee, and Hemanth Kumar VM. "A Cross-Sectional Study on Investigations and Outcome of Cleistanthus Collinus (Vadisaku) Poisoning in A Tertiary Care Center." Journal of Neonatal Surgery 14, no. 29S (2025): 308–13. https://doi.org/10.63682/jns.v14i29s.6782.

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Introduction: Typically found in South India, Cleistanthus collinus (vadisaku) is a poisonous plant belonging to the Euphorbiaceae family. Intentional poisoning during suicide attempts and homicidal intent are frequent uses. Multiple organ systems are affected by the strong toxicological effects of cleistanthin A and B, the plant's poisonous chemicals. Despite its well-established toxicity, little is known about its clinical management and treatment outcome. Objective: To evaluate C. collinus poisoning cases' clinical presentation, test results, and treatment in order to enhance patient outcom
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15

Ragupathi, G., P. Prabhasankar, B. Sundaravadivel, K. S. Annapoorani, and C. Damodaran. "Determination of Cleistanthus collinus Toxins by Enzyme-Linked Immunosorbent Assay." Toxicology Methods 4, no. 3 (1994): 204–13. http://dx.doi.org/10.3109/15376519409041605.

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16

Quraishi, A., and S. K. Mishra. "Micropropagation of nodal explants from adult trees of Cleistanthus collinus." Plant Cell Reports 17, no. 5 (1998): 430–33. http://dx.doi.org/10.1007/s002990050420.

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17

Eswarappa, Shashiraj, Amiya Ranjan Chakraborty, Babu Urumese Palatty, and Mabel Vasnaik. "Cleistanthus Collinus Poisoning: Case Reports and Review of the Literature." Journal of Toxicology: Clinical Toxicology 41, no. 4 (2003): 369–72. http://dx.doi.org/10.1081/clt-120022005.

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18

SATYANARAYANA, P., and K. S. RAMU. "ChemInform Abstract: 3′′-O-Methyl Ether of Cleistanthin-B and an Arylnaphthalenic Anhydride from Cleistanthus collinus Roxb." ChemInform 29, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199848263.

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19

Mohan, Alladi, B. Vengamma, MH Rao, Potikuri Damodaram, IChiranjeevi Manohar, and D. Prabath Kumar. "Myasthenic crisis-like syndrome due to Cleistanthus collinus poisoning." Indian Journal of Medical Sciences 62, no. 2 (2008): 62. http://dx.doi.org/10.4103/0019-5359.39368.

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20

Nagaveni, H. C., B. R. Sheela, G. Vijayalakshmi, and S. H. Jain. "Leaf spot management of Pongamia pinnata seedlings by Cleistanthus collinus plant extracts." Indian Journal of Forestry 35, no. 3 (2012): 307–12. http://dx.doi.org/10.54207/bsmps1000-2012-156xao.

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The in vitro and in vivo antifungal potency of Methanol extract of leaf and bark of Cleistanthus collinus plant were evaluated for their botanical fungitoxicants on Colletorichum gloeosprioides Penz. causing leaf spot in Pongamia pinnata seedlings. Different concentrations of extract (0.25, 0.5, 1 and 2%) of leaf and bark and one fungicide (Indofil-M 45) were appraised against the pathogen in vitro using the ‘poison food technique’. The fungitoxicity was better with leaf than bark extracts. Treatment with 2% leaf extract resulted in complete inhibition of mycelial growth; whereas in 2% bark ex
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21

R, Elangomathavan, Nancy Beaulah S, Hariharan S, and P. Kalaivanan. "Indirect shoot organogenesis from leaf explants of threatened medicinal plant Cleistanthus collinus." International Journal of Advanced Research in Biological Sciences (IJARBS) 4, no. 1 (2017): 58–68. http://dx.doi.org/10.22192/ijarbs.2017.04.01.007.

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22

Bagde, Vishal L., Dipali B. Borkar, A. G. Deshmukh A. G. Deshmukh, and M. S. Dudhare M. S. Dudhare. "Inhibitory Effect of Cleistanthus Collinus Plant Extracts and their Fractions on Glutathione S-transferase activity." International Journal of Scientific Research 2, no. 9 (2012): 10–11. http://dx.doi.org/10.15373/22778179/sep2013/4.

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23

Bagde, Vishal L., Dipali B. Borkar, and A. G. Deshmukh A. G. Deshmukh. "Evaluation of insecticidal activity of Cleistanthus Collinus plant extracts and their fractions against lepidopterian pests." Indian Journal of Applied Research 3, no. 11 (2011): 5–7. http://dx.doi.org/10.15373/2249555x/nov2013/3.

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24

Lourthuraj, A. Amala, M. Masilamani Selvam, M. Saddam Hussain, Abdel-Wahab A. Abdel-Warith, Elsayed M. I. Younis, and Nasser A. Al-Asgah. "Dye degradation, antimicrobial and larvicidal activity of silver nanoparticles biosynthesized from Cleistanthus collinus." Saudi Journal of Biological Sciences 27, no. 7 (2020): 1753–59. http://dx.doi.org/10.1016/j.sjbs.2020.05.008.

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25

Mohanan, C., K. Rajesh Kumar, and K. Yesodharan. "Coniella causing foliage diseases in forest species in Kerala, India." Indian Journal of Forestry 33, no. 3 (2010): 355–60. http://dx.doi.org/10.54207/bsmps1000-2010-rfcqv0.

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Coniella australiensis, C. fragariae, C. granati, C. minima and C. petrakii causing foliage infection in 18 forest species in natural forests, plantations and forest nurseries in Kerala State, India are reported. Six species of Eucalypts, E. camaldulensis, E. citriodora, E. grandis, E. pellita, E. urophylla, E. tereticornis and many clones and provenances of E. tereticornis were found affected with various species of Coniella. Careya arborea, Cleistanthus collinus, Garcinia gummi-gutta, Gmelina arborea, Macaranga peltata, Mikania micrantha, Myristica sp., Persea macrantha, Tabernaemontana heyn
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26

Suman, Thamburaj, Ramaraj Elangomathavan, Soundherrajan Ilavenil, and Samiraj Ramesh. "In vitro cytotoxic effect of Cleistanthus collinus extracts and fractions on mouse cell line." Journal of Applied Pharmaceutical Science 4, no. 10 (2014): 44–46. http://dx.doi.org/10.7324/japs.2014.401008.

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27

Arivoli, S., and T. Samuel. "Larvicidal efficacy of Cleistanthus collinus (Roxb.) (Euphorbiaceae) leaf extracts against vector mosquitoes (Diptera: Culicidae)." Asian Pacific Journal of Tropical Biomedicine 1, no. 2 (2011): S281—S283. http://dx.doi.org/10.1016/s2221-1691(11)60172-x.

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28

Kettimuthu, Kavitha Priya, Archana Kini, A. Soosai Manickam, et al. "Cleistanthus collinus poisoning affects mitochondrial respiration and induces oxidative stress in the rat kidney." Toxicology Mechanisms and Methods 29, no. 8 (2019): 561–68. http://dx.doi.org/10.1080/15376516.2019.1624905.

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29

Sharma, Archana, and Pradeep Vasudeva. "Germination Behaviour and Seedling Growth as Influence by Pretreatments of Seeds of Cleistanthus Collinus Benth under Storage." International Journal of Science and Research (IJSR) 12, no. 11 (2023): 412–18. http://dx.doi.org/10.21275/sr231103115929.

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30

Parasuraman, S., and R. Raveendran. "The effects of aqueous extract of Cleistanthus collinus (Roxb.) (Euphorbiaceae) leaves on rat blood pressure." Pharmacognosy Research 4, no. 3 (2012): 178. http://dx.doi.org/10.4103/0974-8490.99086.

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31

Bisen, G. C. "Evaluation of Candidate Plus Trees of Cleistanthus collinus (Roxb.) for Physico-Chemical Properties of Wood." International Journal of Pure & Applied Bioscience 6, no. 5 (2018): 1134–39. http://dx.doi.org/10.18782/2320-7051.6685.

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32

Subramani, Sathya, Delinda Maneksh, Anita Sidharthan, et al. "Cleistanthus collinus induces type I distal renal tubular acidosis and type II respiratory failure in rats." Indian Journal of Pharmacology 42, no. 3 (2010): 178. http://dx.doi.org/10.4103/0253-7613.66843.

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33

Das N. K., Ramya. "Clinical and Laboratory Profile of Patients Admitted with Cleistanthus Collinus Poisoning in a Tertiary Care Hospital." American Journal of Internal Medicine 3, no. 6 (2015): 14. http://dx.doi.org/10.11648/j.ajim.s.2015030601.14.

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34

Nandakumar, N. V., Murali K. D. Pagala, Sriman A. T. Venkatachari, Tatsuji Namba, and David Grob. "Effect of Cleistanthus collinus leaf extract on neuromuscular function of the isolated mouse phrenic nerve-diaphragm." Toxicon 27, no. 11 (1989): 1219–28. http://dx.doi.org/10.1016/0041-0101(89)90030-5.

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35

Singh, Sajal Clarence, Neetu Prince, Soosai Manickam Amirtham, and Sathya Subramani. "Effect of Cleistanthoside A on blood pressure of rats – Can vasoconstrictors help in Cleistanthus collinus poisoning?" Indian Journal of Pharmacology 56, no. 2 (2024): 146–47. http://dx.doi.org/10.4103/ijp.ijp_491_23.

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36

Prathamanjali, S., Y. T. Rajesh Babu, and T. Vijaya. "<i>In vitro </i>assessment of antimitotic, antiproliferative and anticancer activities of different sections of <i>Cleistanthus collinus</i> (Roxb.) Benth. Ex. Hook. F." Journal of Applied and Natural Science 17, no. 1 (2025): 407–20. https://doi.org/10.31018/jans.v17i1.6324.

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Natural-derived chemicals, particularly secondary metabolites from plants, are gaining attention for their potential as innovative and less harmful anticancer treatments, advancing cancer therapy and developing new medicinal herbs. The present study aimed to investigate the antimitotic, antiproliferative, and anticancer activities of various extracts from the leaves, bark, and fruits of Cleistanthus collinus using the Allium cepa root tip assay, yeast cell model, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against Henrietta Lacks (HeLa) and Michigan Cancer Foun
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37

Parasuraman, Subramani, Ramasamy Raveendran, Balakrishnan Vijayakumar, Devadasan Velmurugan, and Subramani Balamurugan. "Molecular docking and ex vivo pharmacological evaluation of constituents of the leaves of Cleistanthus collinus (Roxb.) (Euphorbiaceae)." Indian Journal of Pharmacology 44, no. 2 (2012): 197. http://dx.doi.org/10.4103/0253-7613.93848.

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38

Kanipandian, Nagarajan, Soundarapandian Kannan, Ramar Ramesh, Periyasamy Subramanian, and Ramasamy Thirumurugan. "Characterization, antioxidant and cytotoxicity evaluation of green synthesized silver nanoparticles using Cleistanthus collinus extract as surface modifier." Materials Research Bulletin 49 (January 2014): 494–502. http://dx.doi.org/10.1016/j.materresbull.2013.09.016.

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39

Nanda Kumar, N. V., and K. M. Vijayalakshmi. "PS-50-8 Experimental myasthenia gravis-like neuromuscular impairment with cleistanthus collinus leaf extract administration in rat." Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control 97, no. 4 (1995): S217. http://dx.doi.org/10.1016/0924-980x(95)93246-p.

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40

Bammigatti, Chanaveerappa, B. S. Surynarayana, K. T. Harichandra Kumar, and S. Ganesh Kumar. "Pattern and outcome of Cleistanthus collinus (Oduvanthalai) poisoning in a tertiary care teaching hospital in South India." Journal of Forensic and Legal Medicine 20, no. 8 (2013): 959–61. http://dx.doi.org/10.1016/j.jflm.2013.08.011.

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41

R, Elangomathavan, Nancy Beaulah S, Hariharan S, and P. Kalaivanan. "Encapsulation of shoot tips and nodal segments of Cleistanthus collinus for short term storage and germplasm exchange." International Journal of Current Research in Biology and Medicine 2, no. 1 (2017): 21–32. http://dx.doi.org/10.22192/ijcrbm.2017.02.01.003.

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42

Adak, Totan, Tanushree Mishra, Govindharaj Guru-Pirasanna-Pandi, et al. "Chemo-prospecting Cleistanthus collinus, Lantana camara and Strychnos nux-vomica for rice pest management under laboratory conditions." Journal of Natural Pesticide Research 5 (September 2023): 100041. http://dx.doi.org/10.1016/j.napere.2023.100041.

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43

Mohan, Alladi, GSivaram Naik, J. Harikrishna, et al. "Cleistanthus collinus poisoning: experience at a medical intensive care unit in a tertiary care hospital in south India." Indian Journal of Medical Research 143, no. 6 (2016): 793. http://dx.doi.org/10.4103/0971-5916.192068.

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44

Snehal, Chavan Nutan Bagul Roshan Shaikh Rahul Gangurde Musad Haji Farukh Pathan. "In Vitro Cytotoxic Effects of Cleistanthins B And Diphyllin on Colorectal Cancer." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4179–85. https://doi.org/10.5281/zenodo.15511434.

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Objective: This study investigates the cytotoxic effects of cleistanthin B and diphyllin on colorectal cancer (CRC) cell lines to assess their potential as therapeutic agents for CRC. Methods: The cytotoxicity of cleistanthin B and diphyllin was assessed through the MTT assay to determine the 50% inhibitory concentrations (IC50) against several CRC cell lines, including HT-29, SW-480, and HCT-15. Apoptotic cell death was evaluated using acridine orange/ethidium bromide (AO/EB) dual staining and flow cytometry. Additionally, the effects of cleistanthin B and diphyllin were tested in combination
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45

Mohanta, Yugal Kishore, Sujogya Kumar Panda, Asad Syed, Fuad Ameen, Akshaya Kumar Bastia, and Tapan Kumar Mohanta. "Bio‐inspired synthesis of silver nanoparticles from leaf extracts of Cleistanthus collinus (Roxb.): its potential antibacterial and anticancer activities." IET Nanobiotechnology 12, no. 3 (2018): 343–48. http://dx.doi.org/10.1049/iet-nbt.2017.0203.

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46

Kovendan, Kalimuthu, Subramaniam Arivoli, Rajan Maheshwaran, Kathirvelu Baskar, and Savariar Vincent. "Larvicidal efficacy of Sphaeranthus indicus, Cleistanthus collinus and Murraya koenigii leaf extracts against filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae)." Parasitology Research 111, no. 3 (2012): 1025–35. http://dx.doi.org/10.1007/s00436-012-2927-5.

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47

Kanipandian, Nagarajan, and Ramar Ramesh. "Biosynthesis and Characterization of Silver Nanoparticles Using Cleistanthus collinus; Investigation on Molecular Mechanism of Apoptosis Cell Death Against Lung Cancer Cells." Asian Pacific Journal of Cancer Biology 9, no. 4 (2024): 527–35. https://doi.org/10.31557/apjcb.2024.9.4.527-535.

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Background: The discovery of novel molecular and cellular signaling pathways for cancer medicines would enhance the efficacy of cancer therapy. In the current study, we made an effort to explore the mitochondrial-mediated apoptosis cell death signaling pathway in A549 lung cancer cells by silver nanoparticles (AgNPs) synthesized from leaf extract of Cleistanthus collinus. Methods: In-depth, A549 lung cancer cells were treated with AgNPs, and further studies such as HOECHST 33342, AO/EB, Rhodamine-123 staining, flowcytometry, RT-PCR, and Western blotting techniques (24, 48, and 72 h) evidenced
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48

Lal, Chaman, Lalji Singh, Varun Attri, and S. Sarvade. "Tree species diversity, distribution and population structure in a tropical dry deciduous forests of Chhatisgarh, India." Journal of Applied and Natural Science 7, no. 2 (2015): 681–85. http://dx.doi.org/10.31018/jans.v7i2.666.

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Tree species diversity, distribution and population structure of tropical forests of Bharnawapara wildlife sanctuary was investigated. The study analyzed the structure of a tropical dry deciduous forest in Chhatisgarh at different sites i.e. closed natural forest, open natural forest and plantation forests of teak. The study was conducted by laying 30 quadrats, each 10 m × 10 m in size at different sites. In total, 246 trees belonging to 28 species of 17 families were recorded from 0.3 ha sampling area. Density ranged between 520 to 990 trees ha-1 subsequently, basal area ranged between 21.50
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49

Kadoo, Monal R., та Rupesh S. Badere. "Modulation of the activity of chitinases and β-1,3 glucanase in seedlings of cucumber and chilli by the aqueous extract of Cleistanthus collinus". Physiological and Molecular Plant Pathology 98 (квітень 2017): 46–53. http://dx.doi.org/10.1016/j.pmpp.2017.03.004.

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50

Vijayalakshmi, K. M., and N. V. Nanda Kumar. "PS-50-9 Confirmatory in vivo electrodiagnostic and electromyographic studies for a new neuromuscular junctional blocking agent from Indian medicinal plant cleistanthus collinus." Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control 97, no. 4 (1995): S218. http://dx.doi.org/10.1016/0924-980x(95)93247-q.

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