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Dissertations / Theses on the topic 'Clinical and laboratory studies'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Bissell, Vincent. "Denture stomatitis : clinical and laboratory studies." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/21623.

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This thesis describes investigations conducted to study factors influencing the outcome of antifungal treatment of denture stomatitis. Clinical, mycolognic, haematologic and prosthodontic factors were evaluated. The humoral and cellular immune responses were also studied. Two antifungal agents were compared: systematically administered fluconazole and topically administered amphotericin. A total of 29 patients were randomised to receive fluconazole 50mg daily for 14 days; 30 were randomised to receive amphotericin lozenges and cream for 28 days. Patients were assessed at the time of entry into

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2

Thomson, Seamus David. "Clinical and Laboratory Studies in Osseointegration." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20130.

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Osseointegration for lower limb amputees entails the anchorage of a percutaneous implant into the residual bone, where a prosthesis may be attached externally. The development of this technology was to overcome the shortcomings of conventional prostheses options for amputees including poor mobility outcomes, limited prosthesis use, and induction or amplification of major diseases. Little is known about the long-term success of Osseointegration, and there are gaps in the available literature of its physiological periprosthetic status for recipients. This body of work evaluates periprosthetic bo

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3

Scott, Alexander. "Tendon overuse pathology : clinical and laboratory studies." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5621.

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Background: Painful tendon overuse pathology (tendinosis) is poorly understood. The objectives were to identify major cell populations within clinical tendinosis lesions, and to examine factors involved in the regulation of tendon cell death, survival, or proliferation. The overarching hypothesis was that both cell death and cell proliferation play roles in the development of tendinosis. Methods: 1: Chronic patellar tendinosis tissue was compared with normal, pain-free patellar tendon using Western blot, immunohistochemistry and in situ hybridization. A variety of cell types were examined in r

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4

Holmes, G. K. T. "Coeliac disease : clinical, laboratory and epidemiological studies." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335382.

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5

Dunk, Arthur Albert. "Clinical and laboratory studies in hepatocellular carcinoma." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293460.

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6

Jepson, Nicholas John Arnold. "Denture soft linings : clinical and laboratory studies." Thesis, University of Newcastle upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287464.

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7

Evgenikos, Nikolaos. "Clinical & laboratory studies in ileoanal pouches." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22196.

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A whole gut lavage study performed in pouch patients showed that there is gut protein loss in ileoanal pouches similar to that in IBD. This protein loss relates to disease activity and may be used as an objective indicator of disease activity in ileoanal pouches. The protein loss is evident in the first few months of pouch function and may settle at a later stage. The whole gut lavage method allowed measurements of haemoglobin in the lavage specimen. This whole gut lavage haemoglobin also coincides with the protein loss. The bleeding however did not relate to the protein loss in all cases. Cyt

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8

Gardiner, Ruth Elizabeth. "Clinical and laboratory studies of skin wound healing." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261927.

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9

Nicol, Mark Patrick. "Studies of childhood tuberculosis." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3177.

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10

Middeldorp, Saskia. "Clinical and laboratory studies in genetic and acquired prothrombotic states." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/81127.

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11

Malik-Kotru, Gayatri. "Laboratory and clinical studies using the slow release fluoride device." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522972.

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12

Laohavinij, Sudsawat. "Laboratory and clinical studies with the novel antipurine antifolate lometrexol." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321259.

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13

Mbewu, Anthony David. "Clinical and laboratory studies of lipoprotein (A) in coronary heart disease." Thesis, Queen Mary, University of London, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283731.

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14

Hsieh, Albert. "A Translational Exploration of Graves’ Disease: Clinical, Laboratory and Animal Studies." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20599.

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Graves’ disease (GD) is an autoimmune disorder, mediated by the thyroid stimulating hormone (TSH) receptor antibody (TRAb). This bioactive antibody causes thyrotoxicosis and it may contribute to extra-thyroidal manifestations, particularly Graves’ ophthalmopathy and pre-tibial myxoedema. Despite its pathogenic role, TRAb is not universally measured to confirm the diagnosis of GD in a hyperthyroid patient with a non-pathognomonic presentation. The modern TRAb assays only quantitate the serum TRAb level without determining its function. Furthermore, the mainstream animal models of GD focus upon

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15

Sinclair, D. "Studies on the immunology and laboratory investigation of B cell neoplasia." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377178.

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16

Pereira, Stephen Paul. "The pathogenesis and non-surgical treatment of gallstones : clinical and laboratory studies." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271458.

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17

McLaughlin, Simon D. "Clinical and laboratory studies of the bacterial pathogenesis and management of pouchitis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5713.

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20-50% of patients develop pouchitis following restorative proctocolectomy for ulcerative colitis (UC). Pre-pouch ileitis (PPI) also develops in some of these patients. Bacteria are implicated in the pathogenesis of pouchitis and antibiotics are the mainstay of treatment. Studies were performed to examine the role of bacteria in the pathogenesis of this disease and to develop new treatment. Further studies examined the prevalence and implications of PPI and the efficacy and complications associated with maintenance antibiotic therapy. 16s rRNA sequencing demonstrated an increase in Proteobacte

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18

Bevan, J. S. "Some clinical and laboratory studies of large pituitary tumours treated with dopamine agonists." Thesis, University of Edinburgh, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382956.

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19

Kwak, Hye-Chung. "Clinical studies and laboratory investigations into the effects of obesity on vascular function." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606356.

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20

Sheen, Sarah Rachel. "Laboratory and clinical studies on plaque and stain inhibition on dentures and teeth." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392963.

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21

Roshdy, Tarek A. A. R. A. "Clinical and laboratory studies of mesenchymal stem cells in long bone fracture nonunion." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/12744/.

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Treatment of atrophic long bone fracture nonunion is challenging with current therapeutic interventions including bone morphogenetic proteins (BM Ps) or autologous mesenchymal stem cells (MSCs). In this work it was hypothesised that, total MSC numbers and their responsiveness to BMPs in the nonunion setting were compromised, leading to poor healing. Additionally, the rationale for systemic injection of MSCs to repair bone is based on a contentious concept of their widespread circulation. To address the number and functional competence of iliac crest bone marrow MSCs in nonunion, this study emp

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22

Landoure, G. "Clinical, laboratory, and genetic studies of families with Charcot-Marie-Tooth type 2C disease." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331894/.

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Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant neuropathy characterized by limb, diaphragm, and laryngeal muscle weakness. We studied five unrelated families with CMT2C, of which two showed significant linkage to chromosome 12q24.11. Linkage analysis excluded this locus in one of the remaining families, suggesting genetic heterogeneity within this CMT subtype. SNP genotyping of samples from affected individuals in the three linked families did not reveal any deletion or copy number variation. All genes in this region were sequenced and two heterozygous missense mutations

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23

Laurell, Carl-Gustaf. "Inflammatory response after cataract surgery : randomized controlled clinical and laboratory studies of different surgical techniques /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2762-6.

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24

Kläy, Mariann. "Clinical and laboratory studies in two year old thoroughbred racehorses with equine rhinovirus 1 infection /." [S.l.] : [s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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25

Stalteri, Lucia <1978&gt. "Simkania negevensis: clinical and laboratory studies in the population of hemodialized and kidney transplanted patients." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7108/1/Stalteri_Lucia_tesi.pdf.

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Simkania negevensis is a bacterium belonging to the order Chlamydiales but with certain biological characteristics different from those of chlamydia, according to which it was classified in the family Simkaniaceae. It is widespread in the environment, due to its ability to survive in amoebae also in phase cystic, for which it was hypothesized a possible transmission after contact with water in which they are present amoebae. So far it is known its role in diseases of the lower respiratory tract, such as childhood bronchiolitis and pneumonia in adults of the community, following its transmiss

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26

Stalteri, Lucia <1978&gt. "Simkania negevensis: clinical and laboratory studies in the population of hemodialized and kidney transplanted patients." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7108/.

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Simkania negevensis is a bacterium belonging to the order Chlamydiales but with certain biological characteristics different from those of chlamydia, according to which it was classified in the family Simkaniaceae. It is widespread in the environment, due to its ability to survive in amoebae also in phase cystic, for which it was hypothesized a possible transmission after contact with water in which they are present amoebae. So far it is known its role in diseases of the lower respiratory tract, such as childhood bronchiolitis and pneumonia in adults of the community, following its transmiss

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27

Leary, Alexandra. "Laboratory and clinical studies of the dual EGFR/HER2 tyrosine kinase inhibitor lapatinib in breast cancer." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538329.

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28

Bhandari, Santosh. "Radiological, clinical and laboratory based studies in the pathogenesis of desmoid tumours in familial adenomatous polyposis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/12787.

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Around 10% of desmoid tumours (DT) in familial adenomatous polyposis (FAP) patients grow relentlessly, causing major morbidity and mortality. Radiological, clinical or cellular predictors of aggressive DT are yet to be identified. The work described in this dissertation aimed to identify such predictors by radiological studies, and to develop management guidelines and identify possible targets for therapy. Nine FAP patients with DT underwent 64 multi detector computed tomography (64-MDCT), 1.5 Telsa magnetic resonance imaging (1.5T MRI), Diffusion Tensor Imaging (DTI), Dynamic Contrast Enhance

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29

Katagiri, Fumihiko. "Studies on clinical pharmaceutical science and laboratory medical application using plasma physiological active peptides levels as biomarkers." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137183.

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30

Humphreys, Alison C. "Clinical and laboratory studies of high dose chemotherapy and peripheral blood progenitor cell transplantation in breast cancer." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323491.

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31

Johansson, Gudrun M. "Clinical and kinematic assessments of upper limb function in persons with post-stroke symptoms." Doctoral thesis, Umeå universitet, Fysioterapi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103244.

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Stroke is a common and multifaceted disease that often involves motor deficits in the upper limb. This thesis investigated reliability and validity of existing clinical assessments of upper limb function in persons with post-stroke symptoms and in non-disabled controls. Study I was conducted in a clinical setting where the Motor Evaluation Scale of Upper Extremity in Stroke patients (MESUPES) was assessed in persons post-stroke by two physiotherapists selected from a group of four. Study II-IV took place in a motion analysis laboratory with an optoelectronic system. Kinematic measures and cli

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32

Elmgren, Frykberg Gunilla. "Movement Control after Stroke : Studies on Sit-to-walk and on the Relations between Clinical and Laboratory Measures." Doctoral thesis, Uppsala universitet, Rehabiliteringsmedicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120715.

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Aims: The principal aims of this research were 1) to extend existing knowledge of the everyday sit-to-walk (STW) transfer in subjects with stroke and in matched controls by exploring temporal, kinematic, and kinetic aspects, and 2) to investigate the relations between some clinical and laboratory measures of postural control and locomotion in stroke rehabilitation and research. Methods: Ten community-living subjects with stroke (mean age 59 years) and ten matched controls were enrolled in the STW studies (Studies I, II, and IV). In the study regarding relations between clinical and laboratory

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33

Webb, Bettine Constance. "Laboratory And Clinical Studies On The Treatment Of Candida-Associated Denture Stomatitis With Sodium Hypochlorite Or Microwave Irradiation." Thesis, The University of Sydney, 1996. http://hdl.handle.net/2123/4974.

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This thesis describes experiments which were carried out at the Institute of Dental Research in Sydney and within the Department of Prosthetic Dentistry at the United Dental Hospital of Sydney between February 1991 and May 1996. The study is concerned with finding practical means of treating chronic atrophic candidosis, also referred to as Candida-associated denture stomatitis and to this purpose two methods of denture disinfection are investigated, namely, sodium hypoclorite denture soak and microwave irradiation. Although the aetiology of denture stomatitis is generally considered to be mult

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34

Webb, Bettine Constance. "Laboratory and clinical studies on the treatment of candida-associated denture stomatitis with sodium hypochlorite or microwave irradiation." University of Sydney, 1996. http://hdl.handle.net/2123/4466.

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Doctor of Philosophy<br>This thesis describes experiments which were carried out at the Institute of Dental Research in Sydney and within the Department of Prosthetic Dentistry at the United Dental Hospital of Sydney between February 1991 and May 1996. The study is concerned with finding practical means of treating chronic atrophic candidosis, also referred to as Candida-associated denture stomatitis and to this purpose two methods of denture disinfection are investigated, namely, sodium hypoclorite denture soak and microwave irradiation. Although the aetiology of denture stomatitis is general

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35

Lewko, Agnieszka. "Evaluation of subjective fatigue associated with chronic obstructive pulmonary disease." Thesis, St George's, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.745459.

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36

Porter, David James. "Clinical and laboratory studies of etoposide phosphate, a novel pro-drug of etoposide : with special reference to pharmcokinetically guided dosing." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264480.

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37

Schilling, Thomas. "The Immune Response to One-Lung Ventilation Clinical and Experimental Studies /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108851.

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38

Aboussafy, David. "Stress, coping, self-efficacy and asthma control, clinic, diary and laboratory studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ64491.pdf.

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39

Aboussafy, David 1969. "Stress, coping, self-efficacy and asthma control : clinic, diary and laboratory studies." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35553.

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Asthma has not declined in morbidity and mortality despite significant advances in medical treatment. A literature review was conducted and a program of research was devised with the goal of improving understanding of why many appropriately treated and educated asthmatics are unable to gain adequate control of their asthma. A review of the literature found that psychological stress was a poorly understood trigger for asthmatic symptoms and a possible factor in poor asthma control. A clinic visit study of adult asthmatics found: (1) life event stress was associated with asthma quality of life b

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40

Plummer, Elizabeth Ruth. "Clinical and laboratory studies to support the first-in-human trial of a novel poly(ADP-ribose) polymerase inhibitor in combination with temozolomide." Thesis, University of Newcastle Upon Tyne, 2004. http://hdl.handle.net/10443/1007.

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Poly(ADP-ribose)polymerase (PARP) is a nuclear enzyme involved in the repair of DNA single strand breaks via the Base Excision Repair pathway (BER). Temozolomide, a DNA alkylating agent recently licensed for the treatment of gliomas and melanoma, produces DNA lesions which are targets for BER. Preclinical studies demonstrate that PARP inhibitors increase the cytotoxicity and antitumour activity of temozolomide suggesting that PARP inhibitors may have a clinical role as chemopotentiating agents. This thesis describes the protocol development of a First-in-Human phase I clinical trial of AGO1469

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41

Bradlow, Anthony. "Clinical and laboratory studies into possible relationships between alcohol and musculoskeletal disorders, with emphasis on rheumatoid arthritis, primary osteoarthritis of the hip and Dupuytren's contracture." Thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/25598.

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42

Hill, Owen T. "Improving prostate cancer detection in veterans through the developement of a clinical decision rule for prostate biopsy." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001575.

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43

Leibring, Ingela. "Metodrumsundervisning : En kvalitativ studie av simulering inom vård- och omsorgsutbildning." Licentiate thesis, Karlstads universitet, Institutionen för pedagogiska studier, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-37845.

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Den här avhandlingen handlar om vårdlärares arbete med simulering av arbetsuppgifter i metodrum Ett metodrum kan ses som en hybrid mellan klassrum och sjukhussal. I denna skolmiljö övas arbetsuppgifter som förekommer inom vård och omsorg. Det saknas patienter att öva på och ibland sjukvårdsmaterial, vilket innebär en utmaning för vårdläraren att skapa en autentisk miljö. Syftet med studien är att undersöka hur vårdlärare arbetar med simulering av arbetsuppgifter i metodrumsundervisning för vuxna elever. Avhandlingen grundar sig på ett sociokulturellt perspektiv och har analyserats med hjälp av

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44

Fedeli, Ligia Maria Giongo. "Implementação do biobanco e do laboratório central e validação do protocolo de laboratório do ELSA-Brasil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-20052013-094808/.

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Introdução: O Estudo Longitudinal de Saúde do Adulto é um estudo de coorte multicêntrico com o objetivo de identificar os fatores de risco associados ao diabetes tipo 2 e à doença cardiovascular na população brasileira. Nosso principal objetivo é explicar a concepção e implementação das rotinas do laboratório central e biobanco do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil); destacando as forças e limitações do protocolo. O segundo objetivo é descrever os pré-testes usados para validar o protocolo de antes do início do estudo. Métodos: O estudo optou pela centralização dos exames em u

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45

Mwai, Leah Wanjiru. "The activities of various antimalarial drugs on Plasmodium falciparum isolates in Kilifi Kenya and studies on mechanisms of resistance." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d90f828a-63d4-48aa-9781-3ca2de55e451.

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Drug resistance is a significant challenge in the fight against malaria. Importantly, reduced efficacy has been reported against artemether (ATM)/Lumefantrine (LM) (LM-ATM), amodiaquine (AQ)/artesunate (AS) (AQ-AS), two important combination treatment regimens in Africa, and against piperaquine (PQ), a drug which has been evaluated as a potential alternative in Africa, in combination with dihydroarteminisin (DHA). Chloroquine (CQ) resistance in P.falciparum is associated with two main transporters PfCRT and PfMDR1. I investigated the mechanisms of resistance to PQ, LM and AQ, with the overall

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46

Faramarzi, Oghani Sohrab. "Clinical laboratory optimization." Thesis, Lille 1, 2018. http://www.theses.fr/2018LIL1I072.

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Cette thèse porte sur l'optimisation de la conception et des décisions opérationnelles des laboratoires d'analyses médicales. Dans cette thèse, un outil d'aide à la décision comprenant des modèles mathématiques, un algorithme heuristique et un modèle de simulation personnalisé est développé pour aider les décideurs à résoudre les principaux problèmes stratégiques, tactiques et opérationnels en conception et gestion des opérations des laboratoires d'analyses médicales. Dans cette thèse, la sélection des machines et la disposition des instruments sont étudiées en tant que principaux problèmes st

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47

Brennand, Janet Elizabeth. "Parturition : laboratory and clinical investigations." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/21645.

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The importance of the appropriate timing of parturition is highlighted by the fact that preterm labour accounts for 85% of the deaths of normally formed babies. In addition, there are clinical situations where induction of labour is required. Attempts to reduce the incidence of preterm labour and facilitate induction require an understanding of the normal processes of labour at term. In this thesis the physiology of parturition is considered, with emphasis on prostaglandin biosynthesis and metabolism, and the regulation thereof, processes which are thought to be pivotal in the mechanism of lab

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48

Doby, Cynthia Funnye. "Awareness of Clinical Laboratory Sciences and Shortage of Clinical Laboratory Scientists in the 21st Century." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/3095.

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Retiring baby boomers and the lack of interest and awareness among college students to enroll in an accredited Clinical Laboratory Science (CLS) program have created a shortage of CLS professionals in the 21st century. The U.S. Bureau of Labor Statistics predicts 18,000 CLS vacancies by 2018. However, only about 5,000 students graduate from accredited CLS programs each year. The purpose of this study was to explore students' perceptions of allied health professions and factors that influenced students and CLS professionals to select CLS as a profession. Bandura's social cognitive career theory

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49

Mostafa, P. A. S. "Dentine hypersensitivity : Clinical and laboratory investigations." Thesis, Bucks New University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380340.

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50

Birring, Surinder S. "Clinical and laboratory features of chronic cough." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/10329.

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Chronic cough is a common presenting symptom to both general practice and respiratory clinics and in up to 20% of patients, the cough remains unexplained after extensive investigation and treatment trials. In this thesis, we have shown that patients with idiopathic chronic cough are predominantly female, have an onset of cough in middle age and have a high prevalence of organ specific autoimmune disease, particularly hypothyroidism. We found that idiopathic chronic cough is associated with a bronchoalveolar lavage lymphocytosis and have suggested that this is due to homing of activated lymphoc

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