Academic literature on the topic 'Clinical Application of iPS Cells'

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Journal articles on the topic "Clinical Application of iPS Cells"

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Qi, Xinyue. "Regulation of Induced Pluripotent Stem Cells(iPS) Differentiation and Disease Model Establishment." BIO Web of Conferences 174 (2025): 01023. https://doi.org/10.1051/bioconf/202517401023.

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Induced pluripotent stem cells (iPS) are multipotent cell types generated by reprogramming adult somatic cells, with broad prospects in disease model establishment, drug screening, and regenerative medicine. This paper delves into the mechanism of iPS cell differentiation, differentiation regulation strategies, and their applications in disease model establishment. Initially, we explore the basic features of iPS cells and their differentiation potential, analyzing the key molecular and signaling pathways influencing the iPS differentiation process. Subsequently, we examine several common diffe
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Hamano, Sayuri, Risa Sugiura, Daiki Yamashita, Atsushi Tomokiyo, Daigaku Hasegawa, and Hidefumi Maeda. "Current Application of iPS Cells in the Dental Tissue Regeneration." Biomedicines 10, no. 12 (2022): 3269. http://dx.doi.org/10.3390/biomedicines10123269.

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When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been establish
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Fukuda, Keiichi. "2) Clinical Application of iPS Cells in Cardiovascular Field." Nihon Naika Gakkai Zasshi 102, Suppl (2013): 106b—107a. http://dx.doi.org/10.2169/naika.102.106b.

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Fukuda, Keiichi. "2) Clinical Application of iPS Cells in Cardiovascular Field." Nihon Naika Gakkai Zasshi 102, no. 9 (2013): 2232–40. http://dx.doi.org/10.2169/naika.102.2232.

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Fukuda, Keiichi. "Clinical application of huma iPS cells for cardiovascular Medicine." Microvascular Reviews and Communications 7, no. 1 (2014): 21. http://dx.doi.org/10.14532/mvrc.7.21.

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Masuda, Shigeo, Shigeru Miyagawa, Satsuki Fukushima, et al. "Eliminating residual iPS cells for safety in clinical application." Protein & Cell 6, no. 7 (2015): 469–71. http://dx.doi.org/10.1007/s13238-015-0170-4.

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Miyagi-Shiohira, Chika, Yoshiki Nakashima, Naoya Kobayashi, et al. "The Development of Cancer through the Transient Overexpression of Reprogramming Factors." Cell Medicine 10 (January 1, 2018): 215517901773317. http://dx.doi.org/10.1177/2155179017733172.

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Although induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem cells, several issues related to the use of iPS cells in clinical applications remain unresolved, including the issue of teratoma formation. We previously reported that the induction of induced tissue-specific stem (iTS) cells from the pancreas (iTS-P) or liver (iTS-L) by the transient overexpression of reprogramming factors, combined with tissue-specific selection and the generation of iTS cells, could have important implications for the clinical
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Konuma, Noriyoshi. "Basic Research and Clinical Application of Induced Pluripotent Stem Cells." Journal of Nihon University Medical Association 75, no. 2 (2016): 56–60. http://dx.doi.org/10.4264/numa.75.2_56.

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Millás-Mur, Jaime. "Clinical and ethical use of induced pluripotent stem cells / Uso clinico ed etico delle cellule pluripotenti indotte." Medicina e Morale 67, no. 3 (2018): 291–305. http://dx.doi.org/10.4081/mem.2018.540.

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Since its discovery, more than a decade ago, induced pluripotent stem cells (iPS) have had a prominent relevance in the environments of biomedical research and, at the same time, their origin has been related to the search for an ethical alternative to use of the stem cells obtained from internal mass of the human embryo. In this article we intend to give an overview of its possible applications in the advancement of biomedicine and its relationship with bioethics. From its possible application to regenerate tissues, after proceeding to their differentiation; testing of drugs for different con
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Lian, Qizhou, Yenyen Chow, Miguel Esteban, Duanqing Pei, and Hung-Fat Tse. "Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases." Thrombosis and Haemostasis 104, no. 07 (2010): 39–44. http://dx.doi.org/10.1160/th10-05-0269.

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SummaryRecent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, inv
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Dissertations / Theses on the topic "Clinical Application of iPS Cells"

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Ang, Main-fong, and 洪明楓. "Ex vivo expansion of hematopoietic stem cells: preclinical studies and clinical application." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3122815X.

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Scott, Michael Andrew. "Biology and clinical application of peripheral blood stem cells mobilised by pharmacological agents." Thesis, Anglia Ruskin University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363925.

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Wang, Wenxia, Zhenbo Zhang, Yin Zhao, et al. "Enrichment and characterization of ovarian cancer stem cells and its potential clinical application." E-CENTURY PUBLISHING CORP, 2017. http://hdl.handle.net/10150/622725.

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The cancer stem cell (CSC) theory proposes that a minor population in tumor cells with specific features, such as self-renewal and reproducible tumor phenotype could contribute to tumor relapse and chemotherapy resistance. Several studies have convincingly documented the existence of ovarian CSC, but questions related to the biologic behavior and specific biomarkers of ovarian CSC remain to be clarified. In the present study, we firstly established a tumor cell line with capability of regenerating tumors through serial transplantation of ovarian tumor tissue in non-obese/severe combined immuno
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Roychowdhury, Sameek. "Interleukin-15 biology, pathophysiology, and pre-clinical application in disease /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1084884532.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains iii, vii, 119 p.; also includes graphics (some col.) Includes bibliographical references (p. 102-119). Available online via OhioLINK's ETD Center
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Espinha, Nuno Miguel Moura. "Bioprocess engineering of induced pluripotent stem cells for application in cell therapy and pre-clinical research." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/11551.

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APRILE, LARA. "Flow-cytometry evaluation of residual Leukemia Stem Cells in Chronic Myeloid Leukemia patients: feasibility and clinical application." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1010532.

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Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the presence of the BCR-ABL1 oncogene, deriving from the t(9;22)-(q34;q11) balanced translocation. The deriving BCR-ABL1 fusion protein has tyrosine kinase activity, and it is capable of inducing the proliferation and expansion of myeloid precursors. Tyrosine kinase inhibitors, drugs capable of blocking the malignant proliferation of cells by directly targeting the BCR-ABL1 kinase activity, have dramatically changed patients’s outcome and improved survival rate. Dormant CML-Leukemia Stem Cells (LSCs) are intrinsi
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Serra, Maria Margarida de Carvalho Negrão. "Process Engineering of Stem Cells for Clinical Application." Doctoral thesis, 2011. http://hdl.handle.net/10362/14140.

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Over the last decade, human embryonic stem cells (hESCs) have garnered a lot of attention owing to their inherent self-renewal ability and pluripotency. These characteristics have opened opportunities for potential stem cell-based regenerative medicines, for development of drug discovery platforms and as unique in vitro models for the study of early human development.(...)<br>Fundação para a Ciência e a Tecnologia
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Yeh, Chi-Jung, and 葉其鎔. "BASIC RESEARCH AND CLINICAL APPLICATION OF PERIPHERAL BLOOD STEM CELLS COLLECTION." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/99950645883131742558.

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碩士<br>高雄醫學大學<br>醫學研究所<br>88<br>Peripheral blood stem cells transplantation ( PBSCT ) has been used increasingly to treat various malignancies and has replaced autologous bone marrow transplantation ( Auto-BMT ) and allogeneic bone marrow transplantation ( Allo-BMT ), which has advantages over ABMT especially in terms of faster hematopoietic recovery, less tumor cells contamination and less side effects etc. The purpose of this study is to report our clinical experience to evaluate two different cells separator i.e. COBE Spectra and MCS3P in the efficiency of collecting stem cells. The correlat
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Wei, Sheng-Hsiu, and 魏聖修. "Clinical Application of Urinary Renal Tubular Epithelial Cells Examination in Nephropathy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6vb644.

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Huang, Min-hui, and 黃閔輝. "Application feasibility of optical micro-manipulation to single cells for clinical studies." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/09209105204762355141.

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碩士<br>中臺科技大學<br>醫學工程暨材料研究所<br>100<br>In this study, the manipulation characteristics of laser tweezers exerted at micro-sized particles are applied for investigating the feasibilities of clinical studies and examinations of single cells by trapping and dragging the experimental subjects: amniotic fluid cells (20 µm) and staphylococcus (1 µm). The experiments include (1) to collect the amniotic fluid cells which are put in the microfluidic chip for the cells separation: to investigate the practical operation parameters, i.e. laser power and dragging speed, in order to harmony with the real dra
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Books on the topic "Clinical Application of iPS Cells"

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Jiang, Shuiping, ed. Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6.

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Shuiping, Jiang, ed. Regulatory T cells and clinical application. Springer, 2008.

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1951-, Schmidt Reinhold E., ed. Natural Killer cells: Biology and clinical application. Karger, 1990.

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Lotze, Michael T. Natural Killer Cells: Basic Science and Clinical Application. Elsevier, 2009.

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Weyand, Birgit, Massimo Dominici, Ralf Hass, Roland Jacobs, and Cornelia Kasper, eds. Mesenchymal Stem Cells - Basics and Clinical Application II. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37944-4.

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Bilko, Nadja M., Boris Fehse, Wolfram Ostertag, Carol Stocking, and Axel R. Zander, eds. Stem Cells and their Potential for Clinical Application. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6469-2.

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Weyand, Birgit, Massimo Dominici, Ralf Hass, Roland Jacobs, and Cornelia Kasper, eds. Mesenchymal Stem Cells - Basics and Clinical Application I. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35671-1.

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Jiang, Shuiping. Regulatory T Cells and Clinical Application. Springer, 2010.

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Jiang, Shuiping. Regulatory T Cells and Clinical Application. Springer London, Limited, 2008.

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Schmidt, Reinhold E. Natural Killer Cells: Biology and Clinical Application. S Karger Pub, 1990.

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Book chapters on the topic "Clinical Application of iPS Cells"

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Eberle, Irina, Mohsen Moslem, Reinhard Henschler, and Tobias Cantz. "Engineered MSCs from Patient-Specific iPS Cells." In Mesenchymal Stem Cells - Basics and Clinical Application II. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/10_2012_156.

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Karagiannis, Peter. "Clinical Potential of Induced Pluripotent Stem Cells." In Medical Applications of iPS Cells. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3672-0_1.

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Caballero, Maria Virginia, Ramon A. Espinoza-Lewis, and Manila Candiracci. "Application of Stem Cells and iPS Cells in Toxicology." In Stem Cells in Toxicology and Medicine. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781119135449.ch2.

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Wada, Haruka, Muhammad Baghdadi, and Ken-ichiro Seino. "Generation of T-Lineage Cells from iPS Cells and Its Application." In SpringerBriefs in Stem Cells. Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-7312-6_6.

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Ly, Dalam, and Terry L. Delovitch. "Innate Regulatory iNKT Cells." In Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6_27.

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Wood, Kathryn J., Andrew Bushell, Manuela Carvalho-Gaspar, et al. "Regulatory T Cells in Transplantation." In Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6_16.

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Kretschmer, Karsten, Irina Apostolou, Panos Verginis, and Harald von Boehmer. "FoxP3 and Regulatory T Cells." In Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6_2.

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Tang, Long, Ning Kang, and Wei He. "γδ T Cells in Immunoregulation." In Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6_30.

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Spaggiari, Grazia Maria, and Lorenzo Moretta. "Interactions Between Mesenchymal Stem Cells and Dendritic Cells." In Mesenchymal Stem Cells - Basics and Clinical Application II. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/10_2012_154.

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Hutton, Jonathon, Clare Baecher-Allan, and David A. Hafler. "Multiple Sclerosis and Regulatory T Cells." In Regulatory T Cells and Clinical Application. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-77909-6_13.

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Conference papers on the topic "Clinical Application of iPS Cells"

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Merchant, Fatima, William Holmes, and Mehmet Toner. "Poloxamer 188 Enhances Functional Recovery of Lethally Heat Shocked Fibroblasts." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1329.

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Abstract Surfactant molecules, specifically triblock polymers such as Poloxamer 188 (P-188) have been shown to restore cell membrane integrity. The objective of this study was to develop functional and morphological assays to determine whether treatment with P-188 after heat shock enhances the recovery of lethally damaged cells. Human foreskin fibroblasts (HFF) were heated in suspension and cell recovery after heat shock was assessed using a functional assay based on the contraction of fibroblasts populated collagen lattices (FPCLs). Experiments were performed to evaluate the effect of various
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Li, Yingchao, Dake Xu, Peiyu Zhang, Wenjie Fu, and Tingyue Gu. "D-amino Acids Enhanced Biocide Mitigation of Problematic Biofilms." In CORROSION 2014. NACE International, 2014. https://doi.org/10.5006/c2014-3877.

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Abstract Biofilms cause biocorrosion and biofouling. Biocorrosion is a major problem in many industries such as oil and gas, as well as water utilities. Biomedical implants such as dental and orthopedic implants also encounter biocorrosion. All bacterial cell walls contain peptidoglycan molecules with peptide stems consisting of four alternating L- and D-amino acids. The peptide stems all have a D-alanine terminus. It has been hypothesized that replacing the D-alanine terminus with another D-amino acid sends a biofilm dispersal signal. Several recent journal papers presented experimental data
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Swanson, William H., and Joost Felius. "Modeling Sensitivity to Perimetric Stimuli: What About the Cortex?" In Vision Science and its Applications. Optica Publishing Group, 1997. http://dx.doi.org/10.1364/vsia.1997.suc.2.

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Automated perimetry is a standard clinical tool for evaluating visual loss due to glaucoma, yet histological studies of donor eyes from patients with glaucoma have shown that 20% - 40% of retinal ganglion cells in a given retinal region may die before a relative scotoma appears1. This finding has lead to a number of proposals for alternative stimulus configurations, with the goal of tapping ganglion cell mosaics in a more efficient manner. Alternative stimuli used in a range of laboratories include short-wavelength automated perimetry (SWAP)2,3, flicker perimetry4,5, and red-on-white perimetry
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Bearse, Marcus A., Erich E. Sutter, Daniel Sim, and Robert Stamper. "Glaucomatous Dysfunction Revealed in Higher Order Components of the Electroretinogram." In Vision Science and its Applications. Optica Publishing Group, 1996. http://dx.doi.org/10.1364/vsia.1996.saa.3.

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Ganglion cells of the retina, whose axons comprise the optic nerve fibers, are lost in glaucoma. To help estimate the extent of ganglion cell loss in the clinic and to establish a diagnosis of glaucoma, measurement of the cup-to-disk ratio of the optic nerve head and psychophysical perimetry are used. These methods can only detect loss after it occurs, however, and up to 40% of the ganglion cells may be lost before visual field defects appear in perimetry1.
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Lovasik, John V., Hélène Kergoat, Pierre Forcier, Robert Wojciechowski, and Etty Bitton. "Topographic and Hemodynamic Changes in the Optic Nerve Head in Humans Subsequent to Experimental Modulation of the Intraocular Pressure." In Vision Science and its Applications. Optica Publishing Group, 1995. http://dx.doi.org/10.1364/vsia.1995.sua3.

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The attrition of nerve fibers in the peripapillary area and the optic nerve head (ONH) in glaucoma has been attributed to mechanical compression of, or aberrant blood flow to the ganglion cell axons comprising the optic nerve1. Recently, greater attention has been focussed on the vascular factors in glaucoma2. Much of the delay in understanding the pathophysiology of glaucoma has been the absence of clinically usable instruments for reliably quantifying subtle structural changes in the ONH, and blood flow in the optic nerve. Fortunately, Petrig and Riva recently demonstrated the applicability
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Bearse, Marcus A., Erich E. Sutter, and Anja M. Palmowski. "New Developments toward a Clinical Test of Retinal Ganglion Cell Function." In Vision Science and its Applications. Optica Publishing Group, 1997. http://dx.doi.org/10.1364/vsia.1997.mb.4.

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We recently developed a method for extracting a component from the human multifocal electroretinogram (ERG) that is generated by ganglion cells1,2. As its latency depends linearly on the estimated length of ganglion cell axons connecting the site of focal stimulation with the disc, this optic nerve head component (ONHC) is presumed to originate from the axons where myelination begins1,2. A second, retinal component (RC) has an invariant latency.
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Swanson, William H., Ronald L. Fellman, John R. Lynn, and Richard J. Starita. "Foveal Ganglion Cell Function in Patients with Stabilized Glaucoma and a Clinically Normal Fovea." In Vision Science and its Applications. Optica Publishing Group, 1996. http://dx.doi.org/10.1364/vsia.1996.saa.4.

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Clinical automated static perimetry for glaucoma typically measures white-on-white increment thresholds for a grid of locations throughout the central visual field.1,2 Relative scotomas (regions of the visual field for which threshold is abnormally high) are early signs of glaucomatous damage. Increase in number, size or depth of relative scotomas is an indication of progression of glaucomatous damage. Surgical reduction of intraocular pressure (IOP) to subnormal levels can halt progression of perimetric defect for several years even in cases of extreme damage.3
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Rodriguez, Marita L., Charles E. Murry, and Nathan J. Sniadecki. "Assessment of Induced Pluripotent Stem Cell-Derived Cardiomyocyte Contractility Using Micropost Arrays." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14640.

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Cardiovascular stem cell therapies have shown increasing promise as a potential therapeutic means for reversing the effects of a myocardial infarction [1]. Out of the currently available sources of human stem cells, human induced pluripotent stem cells (hiPSCs) are very promising in that: the number of cell lines that can be induced to the pluripotent state is extremely vast, they serve as a potential source for patient-specific cardiomyocytes, and their use is non-controversial. However, before they can be used feasibly in a clinical setting, the functional engraftment of these cells into the
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Sutter, Erich E., and Marcus A. Bearse. "Extraction of a Ganglion Cell Component from the Corneal Response." In Vision Science and its Applications. Optica Publishing Group, 1995. http://dx.doi.org/10.1364/vsia.1995.tub2.

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Great efforts have been made over the past decades to find a direct objective measure of retinal damage in glaucoma and optic atrophy. The electroretinogram (ERG) was considered a prime candidate for such a measure, but so far, reliable ERG tests for inner retinal and specifically ganglion cell function are still not available in the clinic. Numerous scientific studies have reported glaucomatous changes in the pattern ERG, but even now many findings remain controversial. Often, the changes reported were significant within a group but not large enough to permit a diagnosis on individual patient
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Wotschadlo, Jana, Bianca Müller, Julia Kühn, et al. "Short-Term Application of Magnetic Core-Shell Nanoparticles—Effect on Immune Cells." In 8TH INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS. AIP, 2010. http://dx.doi.org/10.1063/1.3530052.

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Reports on the topic "Clinical Application of iPS Cells"

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Hu, Jing, Zeyue Ouyang, Yue Guo, and YunZhi Feng. Clinical application and efficacy of mesenchymal stem cells in the regeneration of periodontal defects: a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.5.0097.

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WANG, MIN, Sheng Chen, Changqing Zhong, et al. Diagnosis using artificial intelligence based on the endocytoscopic observation of the gastrointestinal tumours: a systematic review and meta-analysis. InPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0096.

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Review question / Objective: With the development of endoscopic techniques, several diagnostic endoscopy methods are available for the diagnosis of malignant lesions, including magnified pigmented endoscopy and narrow band imaging (NBI).The main goal of endoscopy is to achieve the real-time diagnostic evaluation of the tissue, allowing an accurate assessment comparable to histopathological diagnosis based on structural and cellular heterogeneity to significantly improve the diagnostic rate for cancerous tissues. Endocytoscopy (ECS) is based on ultrahigh magnification endoscopy and has been app
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