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Journal articles on the topic 'Clinical Application of iPS Cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Qi, Xinyue. "Regulation of Induced Pluripotent Stem Cells(iPS) Differentiation and Disease Model Establishment." BIO Web of Conferences 174 (2025): 01023. https://doi.org/10.1051/bioconf/202517401023.

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Induced pluripotent stem cells (iPS) are multipotent cell types generated by reprogramming adult somatic cells, with broad prospects in disease model establishment, drug screening, and regenerative medicine. This paper delves into the mechanism of iPS cell differentiation, differentiation regulation strategies, and their applications in disease model establishment. Initially, we explore the basic features of iPS cells and their differentiation potential, analyzing the key molecular and signaling pathways influencing the iPS differentiation process. Subsequently, we examine several common diffe

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2

Hamano, Sayuri, Risa Sugiura, Daiki Yamashita, Atsushi Tomokiyo, Daigaku Hasegawa, and Hidefumi Maeda. "Current Application of iPS Cells in the Dental Tissue Regeneration." Biomedicines 10, no. 12 (2022): 3269. http://dx.doi.org/10.3390/biomedicines10123269.

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When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been establish

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3

Fukuda, Keiichi. "2) Clinical Application of iPS Cells in Cardiovascular Field." Nihon Naika Gakkai Zasshi 102, Suppl (2013): 106b—107a. http://dx.doi.org/10.2169/naika.102.106b.

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4

Fukuda, Keiichi. "2) Clinical Application of iPS Cells in Cardiovascular Field." Nihon Naika Gakkai Zasshi 102, no. 9 (2013): 2232–40. http://dx.doi.org/10.2169/naika.102.2232.

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5

Fukuda, Keiichi. "Clinical application of huma iPS cells for cardiovascular Medicine." Microvascular Reviews and Communications 7, no. 1 (2014): 21. http://dx.doi.org/10.14532/mvrc.7.21.

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6

Masuda, Shigeo, Shigeru Miyagawa, Satsuki Fukushima, et al. "Eliminating residual iPS cells for safety in clinical application." Protein & Cell 6, no. 7 (2015): 469–71. http://dx.doi.org/10.1007/s13238-015-0170-4.

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7

Miyagi-Shiohira, Chika, Yoshiki Nakashima, Naoya Kobayashi, et al. "The Development of Cancer through the Transient Overexpression of Reprogramming Factors." Cell Medicine 10 (January 1, 2018): 215517901773317. http://dx.doi.org/10.1177/2155179017733172.

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Although induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem cells, several issues related to the use of iPS cells in clinical applications remain unresolved, including the issue of teratoma formation. We previously reported that the induction of induced tissue-specific stem (iTS) cells from the pancreas (iTS-P) or liver (iTS-L) by the transient overexpression of reprogramming factors, combined with tissue-specific selection and the generation of iTS cells, could have important implications for the clinical

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8

Konuma, Noriyoshi. "Basic Research and Clinical Application of Induced Pluripotent Stem Cells." Journal of Nihon University Medical Association 75, no. 2 (2016): 56–60. http://dx.doi.org/10.4264/numa.75.2_56.

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9

Millás-Mur, Jaime. "Clinical and ethical use of induced pluripotent stem cells / Uso clinico ed etico delle cellule pluripotenti indotte." Medicina e Morale 67, no. 3 (2018): 291–305. http://dx.doi.org/10.4081/mem.2018.540.

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Since its discovery, more than a decade ago, induced pluripotent stem cells (iPS) have had a prominent relevance in the environments of biomedical research and, at the same time, their origin has been related to the search for an ethical alternative to use of the stem cells obtained from internal mass of the human embryo. In this article we intend to give an overview of its possible applications in the advancement of biomedicine and its relationship with bioethics. From its possible application to regenerate tissues, after proceeding to their differentiation; testing of drugs for different con

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10

Lian, Qizhou, Yenyen Chow, Miguel Esteban, Duanqing Pei, and Hung-Fat Tse. "Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases." Thrombosis and Haemostasis 104, no. 07 (2010): 39–44. http://dx.doi.org/10.1160/th10-05-0269.

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SummaryRecent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, inv

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11

Ishiy, Felipe Augusto Andre, Roberto Dalto Fanganiello, Karina Griesi-Oliveira, et al. "Improvement ofIn VitroOsteogenic Potential through Differentiation of Induced Pluripotent Stem Cells from Human Exfoliated Dental Tissue towards Mesenchymal-Like Stem Cells." Stem Cells International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/249098.

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Constraints for the application of MSCs for bone reconstruction include restricted self-renewal and limited cell amounts. iPSC technology presents advantages over MSCs, providing homogeneous cellular populations with prolonged self-renewal and higher plasticity. However, it is unknown if the osteogenic potential of iPSCs differs from that of MSCs and if it depends on the iPSCs originating cellular source. Here, we compared thein vitroosteogenesis between stem cells from human deciduous teeth (SHED) and MSC-like cells from iPSCs from SHED (iPS-SHED) and from human dermal fibroblasts (iPS-FIB).

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12

Nishizawa, Masatoshi, Kazuhisa Chonabayashi, Akiko Oishi, et al. "Comprehensive Comparison Of Gene Expression, Genomic DNA Methylation, and In Vitro Hematopoietic Differentiation Among Many Human iPS and ES Cell Lines." Blood 122, no. 21 (2013): 1187. http://dx.doi.org/10.1182/blood.v122.21.1187.1187.

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Abstract Objective Hematopoietic differentiation from human induced pluripotent stem (iPS)/embryonic stem (ES) cell attracts much attention due to its huge potential for regenerative medicine. As indicated by some earlier papers, there is large variation in differentiation potential among pluripotent stem cell (PSC) lines, and this is one of major concerns in clinical application of PSCs. If it becomes possible to predict which PSC line has high differentiation potential without real differentiation experiment, it would greatly contribute to clinical application of PSCs. Although some papers r

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13

Hua, Song, Henry Chung, and Kuldip Sidhu. "Human therapeutic cloning, pitfalls and lack luster because of rapid developments in induced pluripotent stem cell technology." Asian Biomedicine 8, no. 1 (2014): 5–10. http://dx.doi.org/10.5372/1905-7415.0801.256.

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AbstractBackground: Therapeutic cloning is the combination of somatic cell nuclear transfer (SCNT) and embryonic stem cell (ES) techniques to create specific ES cells that match those of a patient. Because ES cells derived by nuclear transfer (SCNT ES cells) are genetically identical to the donor, it will not generate rejection by the host’s immune system and thus therapeutically may be more acceptable. Induced pluripotent stem cells (iPS) are a type of pluripotent stem cell artificially derived from an adult somatic cell by inducing a forced expression of a set of specific pluripotent genes.

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14

Aznar, J., and J. Tudela. "Ten years since the discovery of iPS cells: The current state of their clinical application." Revista Clínica Española (English Edition) 217, no. 1 (2017): 30–34. http://dx.doi.org/10.1016/j.rceng.2016.10.002.

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15

Nishimura, Toshinobu, Shin Kaneko, Haruo Gotoh, et al. "Generation of Monoclonal TCR-Expressing Human T-Lineage Lymphocytes From Induced Pluripotent Stem Cells of Single Peripheral T-Lymphocyte Origin." Blood 116, no. 21 (2010): 490. http://dx.doi.org/10.1182/blood.v116.21.490.490.

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Abstract Abstract 490 T lymphocytes play central roles in cellular immunity, exerting their proliferative and effector activities when they recognize antigens, in HLA-restricted and antigen-specific manner, via T-cell receptors (TCRs). Successful treatment of leukemias/cancers with T-lymphocytes infusions is a direct proof that human immunity has the potential to eradicate cancers. However, continuous exposure to tumor/self antigens drives T lymphocytes into a highly exhausted state, with loss of potentials for long-term survival, proliferation, and effector functions that can end up with dele

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16

Moraghebi, Roksana, Roger Emanuel Rönn, Claudia Stolz, et al. "Comparative Study of Hematopoietic Lineage Potential of Ips Cells Derived From Two Mesodermal Cell Lineages." Blood 118, no. 21 (2011): 1285. http://dx.doi.org/10.1182/blood.v118.21.1285.1285.

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Abstract Abstract 1285 Identifying the key regulatory genes that direct human ES/iPS cell differentiation to certain lineages is required before considering these cells for their potential clinical application. It has been proposed that the cellular starting material used to generate novel iPS cell lines imparts an epigenetic memory which in turn influences the iPS lines' potential to differentiate towards certain developmental lineages. To determine novel key regulators that direct ES/iPS cell differentiation to hematopoietic lineages, we decided to compare differentiation capacity of multipl

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17

Baik, June, Carolina Ortiz-Cordero, Alessandro Magli, et al. "Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells." Cells 12, no. 8 (2023): 1147. http://dx.doi.org/10.3390/cells12081147.

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Pluripotent stem (PS) cells enable the scalable production of tissue-specific derivatives with therapeutic potential for various clinical applications, including muscular dystrophies. Given the similarity to human counterparts, the non-human primate (NHP) is an ideal preclinical model to evaluate several questions, including delivery, biodistribution, and immune response. While the generation of human-induced PS (iPS)-cell-derived myogenic progenitors is well established, there have been no data for NHP counterparts, probably due to the lack of an efficient system to differentiate NHP iPS cell

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18

Boheler, Kenneth R. "Pluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration." Thrombosis and Haemostasis 104, no. 07 (2010): 23–29. http://dx.doi.org/10.1160/th09-07-0507.

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SummaryCardiac and vascular abnormalities and disease syndromes are major causes of death both during human development and with aging. To identify the cause of congenital defects and to combat this epidemic in the aging population, new models must be created for scientific investigation and new therapies must be developed. Recent advances in pluripotent stem cell biology offer renewed hope for tackling these problems. Of particular importance has been the creation of induced pluripotent (iPS) cells from adult tissues and organs through the forced expression of two to four transcription factor

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19

Gois Beghini, Daniela, Samuel Iwao Horita, Cynthia Machado Cascabulho, Luiz Anastácio Alves, and Andrea Henriques-Pons. "Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies." International Journal of Molecular Sciences 21, no. 15 (2020): 5467. http://dx.doi.org/10.3390/ijms21155467.

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Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an embryonic stem cell-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties. These primary factors are octamer-binding transcription factor 4 (Oct3/4), sex-determining region Y-box 2 (Sox2), Krüppel-like factor 4 (Klf4), and the proto-oncogene protein homolog of avian myelocytomatosis (c-Myc). The somatic cell

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20

Tsutsumi, Hiroki, Ryota Kurimoto, Ryo Nakamichi, et al. "Generation of a tendon-like tissue from human iPS cells." Journal of Tissue Engineering 13 (January 2022): 204173142210740. http://dx.doi.org/10.1177/20417314221074018.

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Tendons and ligaments are essential connective tissues that connect the muscle and bone. Their recovery from injuries is known to be poor, highlighting the crucial need for an effective therapy. A few reports have described the development of artificial ligaments with sufficient strength from human cells. In this study, we successfully generated a tendon-like tissue (bio-tendon) using human induced pluripotent stem cells (iPSCs). We first differentiated human iPSCs into mesenchymal stem cells (iPSC-MSCs) and transfected them with Mohawk (Mkx) to obtain Mkx-iPSC-MSCs, which were applied to a ne

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21

Oswald, Julia, and Petr Baranov. "Regenerative medicine in the retina: from stem cells to cell replacement therapy." Therapeutic Advances in Ophthalmology 10 (January 1, 2018): 251584141877443. http://dx.doi.org/10.1177/2515841418774433.

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Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale fro

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22

Prescott, Catherine. "The business of exploiting induced pluripotent stem cells." Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1575 (2011): 2323–28. http://dx.doi.org/10.1098/rstb.2011.0047.

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Induced pluripotent stem cells (iPS cells) can be exploited for both research and clinical applications. The first part of this review seeks to provide an understanding of the financial drivers and key elements of a successful business strategy that underpin a company focused on developing iPS-related products and services targeted at the research market. The latter part of the review highlights some of the reasons as to why the reprogramming of somatic cells is currently being used to develop cell-based models to screen for small molecules with drug-like properties rather than to develop cell

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23

Eto, Koji. "Ex vivo Engineering of Platelets." Blood 134, Supplement_1 (2019): SCI—6—SCI—6. http://dx.doi.org/10.1182/blood-2019-121116.

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Platelet transfusion is necessary for patients in thrombocytopenic states. Due to short shelf life of platelet product, the shortage of blood donors in the younger population as the consequence of aging societies in developed countries and platelet transfusion refractoriness (PTR) caused by alloimmune response, the risk of platelet product shortage has been a concern. Therefore, many attempts to substitute donor-dependent platelet product have been proposed. Induced pluripotent stem cell (iPSC) derived-platelet like particle product (which we refer as iPS-platelets) is aimed to provide measure

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Sugita, Sunao, Ayumi Hono, Shoko Fujino, et al. "Detection of Mycoplasma Contamination in Transplanted Retinal Cells by Rapid and Sensitive Polymerase Chain Reaction Test." International Journal of Molecular Sciences 22, no. 22 (2021): 12555. http://dx.doi.org/10.3390/ijms222212555.

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Contamination of cells/tissues by infectious pathogens (e.g., fungi, viruses, or bacteria, including mycoplasma) is a major problem in cell-based transplantation. In this study, we tested a polymerase chain reaction (PCR) method to provide rapid, simple, and sensitive detection of mycoplasma contamination in laboratory cultures for clinical use. This mycoplasma PCR system covers the Mycoplasma species (spp.) listed for testing in the 17th revision of the Japanese Pharmacopoeia, and we designed it for use in transplantable retinal cells. Here, we analyzed mycoplasma contamination in induced plu

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Imaizumi, Mitsuyoshi, Nicole Y. K. Li-Jessen, Yuka Sato, David T. Yang, and Susan L. Thibeault. "Retention of Human-Induced Pluripotent Stem Cells (hiPS) With Injectable HA Hydrogels for Vocal Fold Engineering." Annals of Otology, Rhinology & Laryngology 126, no. 4 (2017): 304–14. http://dx.doi.org/10.1177/0003489417691296.

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Objective: One prospective treatment option for vocal fold scarring is regeneration with an engineered scaffold containing induced pluripotent stem cells (iPS). In the present study, we investigated the feasibility of utilizing an injectable hyaluronic acid (HA) scaffold encapsulated with human-iPS cell (hiPS) for regeneration of vocal folds. Methods: Thirty athymic nude rats underwent unilateral vocal fold injury. Contralateral vocal folds served as uninjured controls. Hyaluronic acid hydrogel scaffold, HA hydrogel scaffold containing hiPS, and HA hydrogel scaffold containing hiPS with epider

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26

Zhao, Qingguo, Eun-Hye Bae, Yu Zhang, et al. "Inhibitory Effects of Extracellular Vesicles from iPS-Cell-Derived Mesenchymal Stem Cells on the Onset of Sialadenitis in Sjögren’s Syndrome Are Mediated by Immunomodulatory Splenocytes and Improved by Inhibiting miR-125b." International Journal of Molecular Sciences 24, no. 6 (2023): 5258. http://dx.doi.org/10.3390/ijms24065258.

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Extracellular vesicles (EVs) from allogeneic-tissue-derived mesenchymal stem cells (MSCs) are promising to improve Sjögren’s syndrome (SS) treatment, but their application is hindered by high variations in and limited expandability of tissue MSCs. We derived standardized and scalable MSCs from iPS cells (iMSCs) and reported that EVs from young but not aging iMSCs (iEVs) inhibited sialadenitis onset in SS mouse models. Here, we aim to determine cellular mechanisms and optimization approaches of SS-inhibitory effects of iEVs. In NOD.B10.H2b mice at the pre-disease stage of SS, we examined the bi

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27

Hayden, Anna R., Derrick G. Lee, Diego Villa, et al. "Validation of a Simplified International Prognostic Score (IPS-3) in Patients with Advanced Stage Hodgkin Lymphoma." Blood 132, Supplement 1 (2018): 2916. http://dx.doi.org/10.1182/blood-2018-99-111047.

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Abstract Purpose Since its publication in 1998, the International Prognostic Score (IPS-7) has been widely adopted as a risk stratification tool in patients with advanced stage classical Hodgkin lymphoma (cHL).1 In this study, the 5-y freedom-from-progression (FFP) ranged from 42 to 84% and 5-y overall survival (OS) from 56 to 89%. This index has demonstrated utility in the modern era, but with a significantly narrowed prognostic range.2 Further, missing factors can be problematic, limiting utility in clinical practice. A novel prognostic score (IPS-3), comprised of three of the seven IPS-7 in

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28

Miyagi-Shiohira, Chika, Yoshiki Nakashima, Naoya Kobayashi, et al. "Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA." International Journal of Molecular Sciences 19, no. 11 (2018): 3489. http://dx.doi.org/10.3390/ijms19113489.

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Adipose-derived mesenchymal stem cells (ADSCs) have attracted attention due to their potential for use in the treatment of various diseases. However, the self-renewal capacity of ADSCs is restricted and their function diminishes during passage. We previously generated induced tissue-specific stem cells from mouse pancreatic cells using a single synthetic self-replicating Venezuelan Equine Encephalitis (VEE)-reprogramming factor (RF) RNA replicon (SR-RNA) expressing the reprogramming factors POU class 5 homeobox 1 (OCT4), Krueppel-like factor 4 (KLF4), Sex determining region Y-box 2 (SOX2), and

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29

Wang, ZacK Z., Hao Bai, Melanie Arzigian, Yong-Xing Gao, and Wen-Shu Wu. "BMP4 and TGFbeta Differentially Regulate CD34+ Progenitor Development in Human Embryonic Stem Cells through SMAD-Dependent Pathway." Blood 112, no. 11 (2008): 889. http://dx.doi.org/10.1182/blood.v112.11.889.889.

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Abstract Pluripotent stem cells derived from patients, including embryonic stem (ES) cells and “induced pluripotent stem” (iPS) cells, are a promising area of regenerative medical research. A major roadblock toward human clinical therapies using ES cells or iPS cells is to define the factors that direct ES cell differentiation into lineage specific cells. We previously established a simple and efficient human embryonic stem cell (hESC) differentiation system to generate CD34+/CD31+ progenitor cells that gave rise to hematopoietic and endothelial cells (Nat Biotech.25:317, 2007). To advance pot

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Hohenstein Elliott, Kristi A., Cory Peterson, Anuradha Soundararajan, et al. "Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential." Stem Cells International 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/926463.

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Proper maintenance of stem cells is essential for successful utilization of ESCs/iPSCs as tools in developmental and drug discovery studies and in regenerative medicine. Standardization is critical for all future applications of stem cells and necessary to fully understand their potential. This study reports a novel approach for the efficient, consistent expansion of human ESCs and iPSCs using laser sectioning, instead of mechanical devices or enzymes, to divide cultures into defined size clumps for propagation. Laser-mediated propagation maintained the pluripotency, quality, and genetic stabi

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31

Romano, Gaetano, Fátima Morales, Ignazio R. Marino, and Antonio Giordano. "A Commentary on iPS Cells: Potential Applications in Autologous Transplantation, Study of Illnesses and Drug Screening." Journal of Cellular Physiology 229, no. 2 (2013): 148–52. http://dx.doi.org/10.1002/jcp.24437.

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Ranjit, Rebicca, Pratik Manandhar, and Soni Bista. "Exploring the potential of human adipocytes in periodontal regeneration: A review." Journal of Gandaki Medical College-Nepal 13, no. 1 (2020): 68–77. http://dx.doi.org/10.3126/jgmcn.v13i1.28370.

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Stem cells, initially identified in embryonic tissues and later in numerous adult tissues, tend to possess the potentiality to differentiate into various cell types. Though most flexible of all stem cell lines, ethical issues restrict the use of embryonic cells. Furthermore, induced pluripotent stem cells (iPS) and adult stem cells (e.g: bone marrow stroma) can also be used. However, procurement of autologous bone marrow has its potential limitations. An alternate source of autologous adult stem cells which can be procured in large quantities, under local anesthesia, with minimal discomfort wo

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Ueda, Norihiro, Yasusi Uemura, Rhong Zhang, et al. "Generation of BCR-ABL Reactive CD4+ T Helper Cells By Reprograming and Redifferentiation." Blood 126, no. 23 (2015): 3424. http://dx.doi.org/10.1182/blood.v126.23.3424.3424.

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Abstract Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder caused by BCR-ABL fusion protein that has constitutively active tyrosine kinase activity. Although the prognosis of the patient with CML in chronic phase has markedly improved by the advent of tyrosine kinase inhibiters, the management of the patients with CML in advanced phase remains to be the major challenge. Immunotherapy is considered to be one of the promising treatment strategies for refractory CML. BCR-ABL fusion region, b3a2 peptide, represents a neo-epitope that can induce CML-specific immune respons

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Yokoo, Tomoko, Ryo Kurita, Atsushi Takahashi, et al. "Expression Cloning of Genes Enabling Erythropoietin -Independent Erythropoiesis in Vitro." Blood 114, no. 22 (2009): 3608. http://dx.doi.org/10.1182/blood.v114.22.3608.3608.

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Abstract Abstract 3608 Poster Board III-544 Erythropoietin (EPO) is essential during both ontogeny and the course of erythropoiesis. In primitive (yolk sac) erythropoiesis, however, the role of EPO is not fully understood. Elucidation of such role in primitive erythropoiesis would be very helpful for the development of ex vivo red blood cell expansion system from embryonic stem (ES) cells. Recently, we reported the establishment of the ex vivo induction of hematopoietic stem cells from common marmoset ES cells using lentiviral-Tal1/Scl gene transfer in the absence of any stromal cells (Stem Ce

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Migliaccio, Anna Rita F., Carolyn Whitsett, and Giovanni Migliaccio. "Expansion of Red Blood Cells for Transfusion." Blood 116, no. 21 (2010): SCI—46—SCI—46. http://dx.doi.org/10.1182/blood.v116.21.sci-46.sci-46.

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Abstract Abstract SCI-46 Blood transfusion, the earliest form of cell replacement therapy, has become indispensable for modern medicine making the safety and adequacy of the blood supply a national priority. The US blood supply is adequate overall because in 2006 the number of blood units collected exceed by 7.8% the number of those transfused. However, issues surrounding blood transfusion, such as sporadic shortages and potential adverse events to recipients (related to changes in red cell physiology during storage and alloimmunization in chronically transfused patients) prompted past and cur

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Shigetaka, Asano. "Expectations of Epigenetic Research Studies Focusing on Mesenchymal Stem Cells." Studies on Stem Cells Research and Therapy 1, no. 1 (2014): 001. https://doi.org/10.17352/sscrt.000001.

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Epigenetic alternations are not associated with any changing the base sequence of DNA, but are closely related to phenome together  with genome [1]. Most of them are determined differvvently under various  external and internal influences and, even if abnormal, memorized over individual life. In the ontogeny that starts from a totipotent stem cell such as a fertilized egg, the epigenetic alternations occur in good order along with cell differentiation process toward peculiar epigenetic patterns of individual cell series. In  contrast, a reverse artificial phenomenon induced by t

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Yabe, Shigeharu G., Junko Nishida, Satsuki Fukuda, et al. "Definitive endoderm differentiation is promoted in suspension cultured human iPS-derived spheroids more than in adherent cells." International Journal of Developmental Biology 63, no. 6-7 (2019): 271–80. http://dx.doi.org/10.1387/ijdb.180251sy.

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Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are very attractive cell sources for the treatment of diabetes mellitus, because numerous cells can be obtained using their infinite proliferation potential to overcome the paucity of donor islets. Advances in differentiation protocols make it possible to generate glucose responsive hPSC-beta cells, which can ameliorate hyperglycemia in diabetic mice. These protocols have mainly been based on an adherent culture system. However, in clinical applications, suspension culture meth

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Kasirer-Friede, Ana. "Novel Roles and Therapeutic Approaches Linking Platelets and Megakaryocytes to Non-Hemostatic and Thrombotic Disease." International Journal of Translational Medicine 5, no. 3 (2025): 25. https://doi.org/10.3390/ijtm5030025.

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Background: Historically, pharmacological interventions aimed at platelets have targeted their canonical hemostatic and thrombotic roles. The therapeutic vision, however, has minimally embraced alternate mechanisms by which anucleate platelets, their parent cells, megakaryocytes, and cellular derivatives may be utilized to yield novel and effective therapies. Platelets contain storage granules rich in a wide variety of proteins, chemicals, growth factors, and lipid particles that can modulate the fate and activity of diverse cell types, and impact diseases not previously thought to have a plat

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39

Tsuge, Kyoshiro, and Akira Shimamoto. "Research on Werner Syndrome: Trends from Past to Present and Future Prospects." Genes 13, no. 10 (2022): 1802. http://dx.doi.org/10.3390/genes13101802.

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A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is characterized by the early onset of aging-associated diseases, including shortening stature, alopecia, bilateral cataracts, skin ulcers, diabetes, osteoporosis, arteriosclerosis, and chromosomal instability, as well as cancer predisposition. WRN, the gene responsible for WS, encodes DNA helicase with a 3′ to 5′ exonuclease activity, and numerous studies have revealed that WRN helicase is involved in the maintenance of chromosome stability through actions in DNA, e.g., DNA replication, repair, recombination, and ep

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Takaishi, Koji, Masahiro Takeuchi, Shokichi Tsukamoto, et al. "Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells." Blood 132, Supplement 1 (2018): 1789. http://dx.doi.org/10.1182/blood-2018-99-111683.

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Abstract Background : Anagrelide is a widely used therapeutic agent for patients with essential thrombocythemia. While other cytoreductive agents, such as hydroxyurea, influence multi-lineage blood cells, anagrelide exerts less effect on the white and red blood cell lineages. Although the clinical efficacy of anagrelide has been reported, the exact mechanism of action is unclear. Recently, immortalized megakaryocyte progenitor cell lines (imMKCLs) were established from human induced pluripotent stem (iPS) cells by the introduction of doxycycline-inducible lentiviral vectors harboring c-MYC, BM

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Huang, Xiaosong, Bin-Kuan Chou, Prashant Mali, Zhaohui Ye, Sarah N. Dowey, and Linzhao Cheng. "Human IPS Cells Generated From Adult Peripheral Blood Cells and Purified CD34+ Cells by a Non-Integrating Plasmid." Blood 116, no. 21 (2010): 1589. http://dx.doi.org/10.1182/blood.v116.21.1589.1589.

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Abstract Abstract 1589 Human induced pluripotent stem cells (iPSCs) that are functionally similar to embryonic stem cells (ESCs) hold great potential for cell and gene therapies, disease modeling and drug development. The earliest success was achieved by using adherent fibroblastic cells and retroviral vectors that transduce fibroblasts very efficiently. It is also highly desirable to reprogram postnatal blood cells, including those from cord blood (CB) and adult peripheral blood (PB), which are easily accessible and less exposed to environmental mutagens. In 2009, we and others have achieved

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Abenavoli, Elisabetta Maria, Flavia Linguanti, Raffaella Calabretta, Roberto C. Delgado Bolton, Valentina Berti, and Egesta Lopci. "Clinical Application of ImmunoPET Targeting Checkpoint Inhibitors." Cancers 15, no. 23 (2023): 5675. http://dx.doi.org/10.3390/cancers15235675.

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In the last decade, monoclonal antibodies (mAbs) targeting CTLA-4, PD-1, or PD-L1 have been developed and immune checkpoint inhibitors (ICIs) have become the main approach in cancer immunotherapy. However, not all patients benefit from ICI therapy and some are at risk of developing treatment-induced side-effects. These aspects, in parallel with the imaging challenges related to response assessments during immunotherapy, have driven scientific research to the discovery of new predictive biomarkers to individualize patients who could benefit from ICIs. In this context, molecular imaging using PE

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Vucenik, Ivana, Ana Druzijanic, and Nikica Druzijanic. "Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application." Molecules 25, no. 24 (2020): 5931. http://dx.doi.org/10.3390/molecules25245931.

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Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This naturally occurring carbohydrate and its parent compound, myo-inositol (Ins), are abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate important cellular functions. However, the striking and broad-spectrum anticancer activity of IP6, consistently demonstrated in different experimental models, has been in a spotlight of the scientific community dealing with the nutrition and cancer during the last several decad

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Chan, Anthony. "NEURODEGENERATIVE DISEASES." Reproduction, Fertility and Development 24, no. 1 (2012): 288. http://dx.doi.org/10.1071/rdv24n1ab251.

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In the past few decades, a tremendous amount of effort has been invested in developing gene and cell therapies for inherited genetic diseases such as Huntington's disease (HD). However, progress in their clinical application has been very limited. One of the major barriers is the lack of appropriate animal models that allow precise prediction patterns in human patients. Most of the animal models used for gene and cell therapy study are primarily focused on safety and toxicity evaluation, while therapeutic efficacy cannot be fully addressed because they do not carry the same human diseases. Alt

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Jacków, Joanna, Zongyou Guo, Corey Hansen, et al. "CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells." Proceedings of the National Academy of Sciences 116, no. 52 (2019): 26846–52. http://dx.doi.org/10.1073/pnas.1907081116.

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Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder caused by mutations in theCOL7A1gene encoding type VII collagen (C7). The spectrum of severity depends on the type of mutation in theCOL7A1gene. C7 is the major constituent of anchoring fibrils (AFs) at the basement membrane zone (BMZ). Patients with RDEB lack functional C7 and have severely impaired dermal–epidermal stability, resulting in extensive blistering and open wounds on the skin that greatly affect the patient’s quality of life. There are currently no therapies approved for the treatment of RDEB. He

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Saarnilehto, M., M. Pekkanen-Mattila, K. Aalto-Setälä, O. Silvennoinen, and A. Koivisto. "Human inducible pluripotent stem cell-derived sensory neurons express multiple functional ion channels and GPCRs." Scandinavian Journal of Pain 4, no. 4 (2013): 260. http://dx.doi.org/10.1016/j.sjpain.2013.07.017.

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AbstractAimsAim of the study was to characterize functional ion channel and GPCR responses by using selective pharmacological tools and intracellular calcium imaging from human inducible pluripotent stem cell-derived sensory neurons.MethodsSensory neurons were generated from human keratinocytes that were reprogrammed to inducible pluripotent stem cells by using standard Yamanaka factors. Inducible pluripotent stem cells were differentiated into sensory neurons by using 2 differentiation protocols (small molecule and PA6 co-culture). Sensory neurons were loaded with intracellular calcium dye Fl

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Sugimoto, Naoshi, Junya Kanda, Sou Nakamura, et al. "The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness." Blood 138, Supplement 1 (2021): 351. http://dx.doi.org/10.1182/blood-2021-145814.

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Abstract Introduction: Platelet transfusion have saved lives of patients with thrombocytopenia through preventing or treating bleeding complications. Currently, platelet products are provided from blood banks which collect blood from healthy donors. However, our ageing society bears the risk of supply in the future. Furthermore, although the rate is decreasing, alloimmune platelet transfusion refractoriness (allo-PTR) is still found in 5% of platelet transfusion patients. Gestation and previous platelet transfusion cause sensitization to produce alloantibodies mostly against class I human leuk

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Si, Jiechang. "Progress in Research and Application of Novel Tumor ICIs." Theoretical and Natural Science 90, no. 1 (2025): 196–204. https://doi.org/10.54254/2753-8818/2025.gu20975.

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ICIs have become a significant therapy in the course of tumors treating, which is particularly effective in relieving T-cell inhibition, activating the ATIR of the immune system. The ICIs represented by PD1 have been widely used in clinics. In this paper, the principle, biological characteristics and clinical application of ICIs in the treatment of cancer are comprehensively discussed. By preventing ICs from attaching to their ligand, which eliminate the immune function inhibition brought on by ICs, thus reactivating immune cells to play anti-tumor role. Currently, a number of ICIs have achiev

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Sakai, Yoko, Masanari Matsumura, Hideki Yamada, et al. "Development of a Perfusing Small Intestine–Liver Microphysiological System Device." Applied Sciences 13, no. 18 (2023): 10510. http://dx.doi.org/10.3390/app131810510.

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There is an increasing need to develop alternatives to animal modeling and testing for pre-clinical studies as researchers face major challenges, such as the study of dynamic systems in laboratory settings. Microphysiological system (MPS) technology has recently shown great potential for addressing such limitations. We developed a perfusing small intestine–liver-connected device that is easy to operate and highly reproducible. In non-clinical pharmacokinetics and safety studies, the use of human-derived materials is necessary. We used human iPS cell-derived small intestinal epithelial cells (H

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Chi, Mingxuan, Tao Jiang, Xing He, et al. "Role of Gut Microbiota and Oxidative Stress in the Progression of Transplant-Related Complications following Hematopoietic Stem Cell Transplantation." Oxidative Medicine and Cellular Longevity 2023 (April 18, 2023): 1–15. http://dx.doi.org/10.1155/2023/3532756.

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Hematopoietic stem cell transplantation (HSCT), also known as bone marrow transplantation, has curative potential for various hematologic malignancies but is associated with risks such as graft-versus-host disease (GvHD), severe bloodstream infection, viral pneumonia, idiopathic pneumonia syndrome (IPS), lung fibrosis, and sinusoidal obstruction syndrome (SOS), which severely deteriorate clinical outcomes and limit the wide application of HSCT. Recent research has provided important insights into the effects of gut microbiota and oxidative stress (OS) on HSCT complications. Therefore, based on

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