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Relevant bibliographies by topics / Clinical biochemistry / Dissertations / Theses

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Dissertations / Theses on the topic 'Clinical biochemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

McCoy, Maurice Anthony. "Hypomagnesaemia in ruminants : incidence, clinical biochemistry and control." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300617.

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2

Ricketts, David John. "Reconfiguration and modernisation of a district general hospital clinical biochemistry service." Thesis, University of Portsmouth, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516885.

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Context: The clinical biochemistry department at the North Middlesex University Hospital successfully won funding under the pathology modernisation initiative to automate the core laboratory in 2000. Following procurement procedures, the contract was awarded to two vendors who offered an 'islands of automation' solution as opposed to the popular fully tracked solution. The automation was installed with minor process change, but process reviews occurring in 2003 with the advent of Lean Six Sigma. Methods: The Executive War College meeting in 2003 introduced new quality management tools Lean, Si

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3

Baral, Randolph Matias. "Feline clinical biochemistry: new paradigms for interpreting results and comparing analysers." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13616.

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The overall aim of this project was to provide an evidence-based means for comparison of feline biochemical analytes to increase the ability to distinguish between sickness and health of cats and enhance veterinarians’ clinical decision-making. Chapter 1, the literature review, has two sections; the first outlines how traditional, population-based reference intervals are generated, followed by a description of subject-based reference limits that are being implemented in human clinical pathology. The second section describes the current approaches for method comparison of analyte values obtai

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4

Jones, R. M. L. "Studies of proteolytic fragments of clinical interest." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354831.

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5

Leslie, Carolyn Elizabeth. "Studies on clinical isolates of Aspergillus Fumigatus." Thesis, Heriot-Watt University, 1985. http://hdl.handle.net/10399/1653.

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6

McLellan, Antony Christopher. "The glyoxalase system in clinical diabetes mellitus." Thesis, University of Essex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333336.

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7

Rowan, Andrew D. "The pineapple proteinases : characterization and clinical use." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290495.

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8

John, W. G. "Glycated proteins : Their measurement and clinical applications." Thesis, De Montfort University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376968.

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9

Smellie, W. Stuart A. "Clinical applications of an assay for intact proinsulin." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308805.

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10

O'Harte, Finbarr Paul Mary. "Clinical biochemistry of cobalt deficiency in sheep with particular reference to methylmalonic acid." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336127.

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11

Miller, Julie. "Antibiotic-modifying enzymes and their use in clinical analysis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302782.

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12

Petty, Richard Kenneth Holdsworth. "A clinical study of mitochondrial myopathies." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329160.

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13

Bradley, Victoria. "Determining sub-arachnoid haemorrhage in the clinical biochemistry laboratory utilising cerebrospinal fluid samples." Thesis, University of Portsmouth, 2013. https://researchportal.port.ac.uk/portal/en/theses/determining-subarachnoid-haemorrhage-in-the-clinical-biochemistry-laboratory-utilising-cerebrospinal-fluid-samples(b68c29d7-afbe-4e20-9c26-a293df652963).html.

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Introduction: Sub-arachnoid haemorrhage (SAH) occurs when cerebral artery ruptures and blood leaks out into the sub-arachnoid space. This is often a catastrophic event for the individual and morbidity and mortality rates are significantly influenced by early intervention. This makes the role of the clinical biochemistry laboratory in early diagnosis vitally important, as delays in diagnosis can have a major clinical impact. The cerebrospinal fluid (CSF) of healthy individuals is optically clear. It has, however, been recognised for over a century that it can become coloured (xanthochromia) fol

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14

Rocha, Susana Maria Santos. "Biological Aspects Underlying the Clinical Outcome of Hereditary Spherocytosis." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63809.

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Rocha, Susana Maria Santos. "Biological Aspects Underlying the Clinical Outcome of Hereditary Spherocytosis." Tese, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63809.

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16

Melton, R. G. "Physiological properties of carboxypeptidase G2 : Polymer conjugates and their clinical application." Thesis, Birmingham City University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374679.

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17

Donoghue, Alan M. "Acute heat illness in underground miners : the clinical state, haematology, biochemistry and risk factors." Thesis, Curtin University, 2000. http://hdl.handle.net/20.500.11937/2196.

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Objectives - To examine the incidence, clinical state, personal risk factors, haematology and biochemistry of heat exhaustion cases occurring at a deep underground metalliferous mine. To describe the underground and surface thermal conditions associated with the occurrence of heat exhaustion cases.Methods - A one-year prospective case-series of acute heat exhaustion cases was undertaken at a deep underground metalliferous mine in tropical and Australia. A case-control study of body mass index (BMI) and maximal oxygen uptake (VO(subscript)2max) in heat exhaustion was also undertaken. A history

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Donoghue, Alan M. "Acute heat illness in underground miners : the clinical state, haematology, biochemistry and risk factors." Curtin University of Technology, School of Public Health, 2000. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=11757.

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Objectives - To examine the incidence, clinical state, personal risk factors, haematology and biochemistry of heat exhaustion cases occurring at a deep underground metalliferous mine. To describe the underground and surface thermal conditions associated with the occurrence of heat exhaustion cases.Methods - A one-year prospective case-series of acute heat exhaustion cases was undertaken at a deep underground metalliferous mine in tropical and Australia. A case-control study of body mass index (BMI) and maximal oxygen uptake (VO(subscript)2max) in heat exhaustion was also undertaken. A history

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19

Fry, Ian David Robert. "Oxalate analysis and its applications." Thesis, University of Surrey, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292296.

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20

Cook, Adrian Gerald. "Bispecific monoclonal antibodies : their potential advantages in immunoassay systems." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295751.

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21

Raffan, Eleanor. "Rare syndromes of perturbed insulin action and production : application of exome sequencing and characterisation of their cellular phenotypes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648236.

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22

Wycherley, Darren. "The application of capillary electrophoresis and mass spectrometry to clinical and environmental problems." Thesis, Open University, 1996. http://oro.open.ac.uk/19806/.

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Using capillary electrophoresis (CE) as a separation technique has allowed analytes, previously difficult to separate by standard methods because they did not conform to requirements for GC or HPLC, to be separated with speed and great efficiency. The only requirements for CE analysis are that the sample is soluble in a liquid matrix and that analytes are present as positive or negative ions whilst in this matrix. This technique has been used here to analyse both clinical and environmental samples, some as cations and others boron-containing complexes as anions. Samples were analysed using a c

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23

Harvey, Roderick David. "Studies on the clinical utility of the measurement of serum thyroglobulin in man." Thesis, University of Aberdeen, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292621.

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Thyroglobulin (Tg) was extracted from human thyroid, purified by gel column chromatography, identified by its thyroxine content, and quantitated by accurate protein determination. The material was used for standards and a radioiodinated tracer in a radioimmmunoassay for serum thryoglobulin, and in an ELISA assay for thyroglobulin autoantibodies. The radioimmunoassay utilised a polyclonal rabbit anti-human-Tg antibody, and separation of bound and free fractions was achieved by a precipitating antiserum and centrifugation. Assay sensitivity was 1ug/1, and the inter and intra-assay CV 16-23% and

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24

Adbeish, Idris S. "Clinical biochemistry of lipoproteins : altered expression of LDL-R and PDGF-A genes in hyperlipidaemia." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307805.

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25

Moreton, Jennifer Anne. "The application of inductively coupled plasma source mass spectrometry to clinical biochemistry and environmental science." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242920.

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26

Woods, Nicole Natasha Brooks Lee R. "The role of biomedical knowledge in medical diagnosis by learners." *McMaster only, 2005.

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27

Hunt, C. "The clinical and biochemical effects of vitamin C supplementation in acutely ill, hospitalised elderly patients." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384613.

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28

Wabomba, Mukire John. "Signal and Image Processing Techniques for Environmental and Clinical Applications of Infrared Spectroscopy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040131767.

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29

Silva, Sueli de Oliveira. "Oxidação de melatonina de formação de N1-acetil-N2-formil-5-metoxiquinuramina: possíveis efeitos biológicos." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-27012009-134118/.

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Em trabalho anterior verificamos que neutrófilos oxidam o hormônio melatonina a N1-acetil-N2-formil-5-metoxiquinuramina (AFMK), numa reação catalisada por mieloperoxidase e dependente de ânion superóxido. Neste trabalho acompanhamos a cinética de formação de AFMK e de seu produto de deformilação N1-acetil-5-metoxiquinuramina (AMK) quando neutrófilos foram ativados por diferentes estímulos. No sentido de obtermos informações sobre a relevância biológica destas reações, avaliamos o efeito de melatonina, AFMK e AMK sobre a formação de HOCl, sobre a liberação de citocinas pró-inflamatórias (TNF-&#

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30

Bani, Rashaid Ayat H. "Clinical and Forensic Biomarkers in Human Hair." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407256298.

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31

Ramsay, Amanda. "The role of high density lipoprotein subspecies in the control of lipoprotein metabolism in relation to clinical disorders." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338398.

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In order to examine the role of HDL in the control of lipoprotein metabolism, the levels of HDL subspecies, other lipoproteins, apolipoproteins and fatty acids were measured in four groups of subjects presenting clinical disorders which were possibly related to their lipid profiles. (1) A monoclonal antibody was raised against apolipoprotein A-I allowing the development of an ELISA. (2) In a comparison of 43 angina patients and 61 healthy control subjects, the levels of HDL<sub>2</sub>, HDL<sub>2b</sub> and HDL<sub>2a</sub> were lower in the angina group and this was compensated for by an incr

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32

Costa, Hugo Leonardo Riani [UNESP]. "Caracterização das alterações laboratoriais e histopatológicas associadas à obstrução uretral experimentalmente induzida em ratos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/89277.

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Made available in DSpace on 2014-06-11T19:23:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-12-11Bitstream added on 2014-06-13T19:51:02Z : No. of bitstreams: 1 costa_hlr_me_botfmvz.pdf: 1355195 bytes, checksum: 2992cd80d156a33c682f6ce67ff9724e (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A obstrução uretral é uma emergência clínica freqüente no atendimento de pequenos animais. Com a evolução do quadro, ocorre parada na filtração glomerular e, consequentemente, desenvolvem-se várias alterações nos equilíbrios hídrico, eletrolítico e ácido-básico, além d

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33

Novais, Adriana Alonso [UNESP]. "Prevalência dos antígenos eritrocitários caninos em cães domésticos (Canis familiaris) e investigação dos parâmetros hematológicos e da ocorrência de antígenos eritrocitários em lobos-guará (Chrysocyon brachyurus) e cachorros-do-mato (Cerdocyon thos) criados no Brasil." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/103773.

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Made available in DSpace on 2014-06-11T19:32:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-01-31Bitstream added on 2014-06-13T21:05:04Z : No. of bitstreams: 1 novais_aa_dr_jabo.pdf: 165876 bytes, checksum: f8f9bf00cfe11abd0988d6ea3897a700 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O propósito desse estudo foi verificar a prevalência dos antígenos eritrocitários caninos em cães domésticos criados no Brasil e compará-la com aquela descrita na literatura consultada, para cães oriundos de outros países. Além disso, verificar os valores sangüíneos normai

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34

Zhao, Linshu. "CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 8 (CEACAM8) : Purification, Characterization, Cellular and Clinical Studies." Doctoral thesis, Uppsala University, Clinical Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4534.

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<p>A 95-kDa protein was purified from normal human granulocytes. The protein reacted with a monoclonal antibody against CEACAM8. MALDI-Tof and MS/MS analyses revealed the protein to be a CGM6 gene product. Thus, the protein was proved to be identical to CEACAM8. </p><p>An ELISA for CEACAM8 was developed with detection range of 1-64μg/L. Data are presented on the levels of CEACAM8 in the blood of healthy individuals and patients undergoing surgery, as well as in patients with acute infection. The highly elevated levels of CEACAM8 in the blood of these patients were significantly correlated with

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Novais, Adriana Alonso. "Prevalência dos antígenos eritrocitários caninos em cães domésticos (Canis familiaris) e investigação dos parâmetros hematológicos e da ocorrência de antígenos eritrocitários em lobos-guará (Chrysocyon brachyurus) e cachorros-do-mato (Cerdocyon thos) criados no Brasil /." Jaboticabal : [s.n.], 2003. http://hdl.handle.net/11449/103773.

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Orientador: José Jurandir Fagliari<br>Banca: Aureo Evangelista Santana<br>Banca: Luis Carlos de Mattos<br>Banca: Aguemi Kuhayagawa<br>Banca: José Mauricio Barbanti Duarte<br>Resumo: O propósito desse estudo foi verificar a prevalência dos antígenos eritrocitários caninos em cães domésticos criados no Brasil e compará-la com aquela descrita na literatura consultada, para cães oriundos de outros países. Além disso, verificar os valores sangüíneos normais e a ocorrência dos antígenos eritrocitários caninos em lobos-guará e cachorros-do-mato, na expectativa de adicionar novos dados sobre valores s

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36

Whitfield, David. "An investigation into the relationships between synaptic biochemistry, clinical symptoms and pathology in the Lewy body dementias and Alzheimer's disease." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-into-the-relationships-between-synaptic-biochemistry-clinical-symptoms-and-pathology-in-the-lewy-body-dementias-and-alzheimers-disease(94c45525-9f7f-490b-9cb4-073420d76f22).html.

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Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are, combined, the second most common type of dementia in the elderly but remain both poorly understood and researched. Diagnosis is based upon clinical symptoms yet there is considerable overlap between DLB, PDD and Alzheimer’s disease (AD), in terms of clinical presentation and pathology. Synapses are critical for neuronal communication and form the basis of memory and behaviour. The loss of zinc transporter 3 (ZnT3) has been implicated in age-related cognitive decline (based upon work in ZnT3- knockout mice), an observat

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37

Lindmark, Eva. "Leukocytes and Coronary Artery Disease : Experimental and Clinical Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5204-3/.

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Hameed, Rana Majeed. "The application of aqueous two phase systems to the analysis of protein isoforms of importance in clinical biochemistry and biopharmaceutical production." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/14452.

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Aqueous Phase Partitioning has a long history of applications to the analytical characterisation of biomolecules. However process applications have attracted the most interest in biotechnology where it has become widely recognized as a cost-effective technique. The main aim of this work was to explore the proposition that partition in Aqueous Two Phase Systems (ATPS) can be used as an analytical tool to detect protein isoforms and to assess the applicability of the method in clinical assays and for quality control in bioprocessing through examination of several analytical problems. The work al

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Persson, Johanna. "Hälsoundervisning : Elevers syn på hälsa inom ämnet Idrott och hälsa." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2478.

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<p>Fler unga människor än någonsin är idag överviktiga och stress och stressrelaterade symptom drabbar idag allt fler unga. Därför är det viktigt att unga människor får kunskaper om hur de på bästa sätt kan ta hand om sig själva.</p><p> Syftet med detta arbete är att undersöka hur elever som läser gymnasiets kurs Idrott och hälsa A ser på den hälsoundervisning de får.</p><p>Detta är relevant för alla som arbetar som idrott och hälsa lärare för att kunna hitta en jämkning mellan kursplan och elevernas tankar och förkunskaper.</p><p> Genom intervjuer och fokusintervjuer kom jag fram till att ele

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Tsujita, Maristela. "Estudo da S-nitrosação de Ras e participação das MAP quinases (ERK, JNK e p38) na apoptose de células THP-1 induzida por óxido nítrico." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-29042016-125624/.

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Ras é uma proteína G monomérica que converte estímulos extracelulares em sinais bioquímicos intracelulares e controla uma variedade de processos biológicos, tais como, proliferação, diferenciação, adesão e morte celular por apoptose. Além da ativação mediada por fatores de crescimento e hormônios, Ras pode ser ativado pela interação com o óxido nítrico (NO·), um radical capaz de mediar processos de sinalização. Essa interação resulta na S-nitrosação do resíduo de cisteína 118 de Ras. Assim, propusemo-nos avaliar a participação da proteína Ras e das MAP quinases: ERK1/2, JNK e p38 no proce

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Burger, Cristiani. "Lipoproteína da alta densidade (HDL) como transportadora da proteína amilóide sérica A (SAA) para sítios inflamatórios: lípides, apolipoproteínas e citocinas inflamatórias em exsudato pleural." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-06092017-122654/.

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Resultados obtidos anteriormente pelo nosso grupo mostraram que a proteína de fase aguda amilóide sérica A (SAA) é um potente estímulo para a expressão de mRNA e liberação de TNF-α, IL-1-β e IL-8 em leucócitos humanos, além de atuar como priming para a liberação de espécies reativas de oxigênio (EROs) por neutrófilos. Nosso objetivo, nesse trabalho, foi mostrar a presença de SAA em exsudatos e definir sua origem, além de verificar sua atividade pró-inflamatória in vivo. Para tanto, utilizamos soro e exsudatos pleurais de 32 pacientes com pneumonia. Mostramos primeíramente a presença

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Costa, Hugo Leonardo Riani. "Caracterização das alterações laboratoriais e histopatológicas associadas à obstrução uretral experimentalmente induzida em ratos /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/89277.

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Orientador: Regina K. Takahira<br>Banca: Raimundo de Souza Lopes<br>Banca: André Marcelo Conceição Meneses<br>Resumo: A obstrução uretral é uma emergência clínica freqüente no atendimento de pequenos animais. Com a evolução do quadro, ocorre parada na filtração glomerular e, consequentemente, desenvolvem-se várias alterações nos equilíbrios hídrico, eletrolítico e ácido-básico, além do acúmulo de metabólitos nitrogenados e toxinas orgânicas. Podem ocorrer modificações histopatológicas nos rins e na bexiga. Objetivou-se, neste estudo, caracterizar prospectivamente as alterações laboratoriais e

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Neto, Lídio Gonçalves Lima. "Polimorfismo dos genes CD14, TLR2, TLR4, IL6 e sua associação com o infarto do miocárdio em adultos jovens." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-18022014-101606/.

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O objetivo deste estudo foi avaliar a possível associação entre os polimorfismos -260C/T do gene CD14, Arg753Gln do gene TLR2, Asp299Gli e Thr39911e do gene TLR4 e -174G/C do gene IL6 com o infarto do miocárdio em adultos jovens. Para isso, foi realizado um estudo caso controle, sendo o grupo de estudo constituído por 102 pacientes que tiveram de infarto do miocárdio (34,5 ± 5 anos) e o grupo controle (35,1±8,7 anos) por 108 indivíduos sem histórico de doenças cardiovasculares. A genotipagem foi realizada pela PCRRFLP. Houve ausência de associação entre a distribuição dos genótipos dos SNPs -2

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Lu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.

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Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

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46

Borg, Mathias. "Study of the insulin-like peptide 3 in human platelets." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21016.

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<p>The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment. [2]</p><p>INSL3 mRNA has recently been verified in human platelets whereas no mRNA has been detected for LGR8 (by Sanofi-Aventis GmbH in Frankfurt,Germany), indicating that INSL3 might be released through paracrine functions at sites of platelet adhesion and aggregat

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Pereira, Edimar Cristiano. "Avaliação dos metabólitos do óxido nítrico, inibidores endógenos do óxido nítrico sintase e homocisteína na intolerância à glicose e no diabetes." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-02082017-160501/.

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A redução da biodisponibilidade óxido nítrico (•NO) tem sido responsável por complicações vasculares em algumas doenças, incluindo Diabetes Mellitus tipo 2 (DMII). A disfunção endotelial (DE) pode ser ocasionada pela baixa biodisponibilidade do •NO e estudos indicam que a hiperglicemia pode estar contribuindo para esse evento. Outro fato importante é que grande parte dos indivíduos que apresentam Intolerância à Glicose (IG) evolui para DMII. Portanto, o objetivo desse trabalho foi avaliar de que forma o estado hiperglicêmico poderia interferir sobre os metabólitos do •NO (S-n

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Okino, Alessandra Miyuki. "Proteínas de fase aguda em exsudatos: acesso da HDL ao foco inflamatório." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-26012015-133436/.

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A fase aguda é caracterizada pela mudança significativa nos níveis de váriasproteínas plasmáticas. As proteínas amilóide sérica A (SAA) e proteína C reativa (PCR), chamadas de proteínas de fase aguda positivas, têm sua concentração plasmática aumentada em até 1000 vezes durante a inflamação. Espera-se que estas proteínas exerçam um papel importante em algumas etapas do processo inflamatório. Para a PCR existem sólidas evidências de sua participação na ativação do sistema complemento, entretanto para a SAA, a função biológica ainda está para ser esclarecida. No plasma, a SAA encontra-se ligada

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Libardi, Keli Daiane Cristina. "Perfil metabólico de cordeiros Santa Inês terminados em confinamento." Universidade Estadual do Oeste do Paraná, 2014. http://tede.unioeste.br:8080/tede/handle/tede/1550.

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Made available in DSpace on 2017-07-10T17:47:59Z (GMT). No. of bitstreams: 1 Keli_Daiane_Cristina_Libardi.pdf: 609346 bytes, checksum: 9d2f5e1eae17be2f4ce41ad4684227d8 (MD5) Previous issue date: 2014-02-28<br>The objective of this study was to evaluate levels of food restriction followed by refeeding on the metabolic profile of lambs finished in feedlot. For this purpose, 24 male sheep were used at 20 kg body weight in a randomized and four restriction levels (0, 20, 40 and 60%) and 6 replicates per treatment design. The experiment was divided into two distinct periods of 64 days each, at

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Jalali, Sefid Dashti Mahjoubeh. "Development of a pathology-supported genetic test for improved clinical management of patients diagnosed with multiple sclerosis." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5407.

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Thesis (MScMedSc (Pathology. Chemical Pathology))--University of Stellenbosch, 2010.<br>Bibliography<br>ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown, due to its multifactorial nature with environmental and genetic factors contributing to the risk. Several investigations highlighted the important role of the genetic component influencing disease susceptibility and progression. In the present study genetic variations in the MTHFR (1298 A>C and 677 C>T) and HFE (845 G>A) genes previously, shown to affect folate and iron metabolism respectively, were studied

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