Academic literature on the topic 'Clinical biostatistics'

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Journal articles on the topic "Clinical biostatistics"

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Batra, Manu, Mudit Gupta, Subha Soumya Dany, and Prashant Rajput. "Perception of Dental Professionals towards Biostatistics." International Scholarly Research Notices 2014 (October 29, 2014): 1–6. http://dx.doi.org/10.1155/2014/291807.

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Biostatistics is becoming an integral part of dental sciences. Awareness regarding the subject is not thoroughly assessed in the field of dentistry. So the study was conducted to assess dental professionals’ knowledge, attitude, and perception toward biostatistics at an academic dental institution. An anonymous cross-sectional questionnaire survey was conducted among all the faculty and postgraduate students of two dental colleges in Moradabad, Uttar Pradesh. The responses were assessed on 5-point likert scale. The survey response rate was 73.71%. Two-thirds of respondents believed biostatisti
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Brown, R. A., J. A. Ingelfinger, F. Mosteller, L. A. Thibodeau, and J. H. Ware. "Biostatistics in Clinical Medicine." Biometrics 44, no. 3 (1988): 915. http://dx.doi.org/10.2307/2531609.

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Kocher, Mininder S., and David Zurakowski. "Clinical Epidemiology and Biostatistics." Journal of Bone & Joint Surgery 86, no. 3 (2004): 607–20. http://dx.doi.org/10.2106/00004623-200403000-00024.

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Takeuchi, Masahiro. "BIOSTATISTICS FOR CLINICAL RESEARCH." Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 80, no. 7 (2019): 1426–27. http://dx.doi.org/10.3919/jjsa.80.1426.

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Price, Wayne A. "Basic and clinical biostatistics." Journal of Pediatrics 118, no. 4 (1991): 560. http://dx.doi.org/10.1016/s0022-3476(05)83379-7.

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Bethel, James. "Biostatistics in Clinical Trials:." Controlled Clinical Trials 23, no. 5 (2002): 536–37. http://dx.doi.org/10.1016/s0197-2456(02)00212-x.

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Rosenbaum, Sara E. "Basic and Clinical Biostatistics." JAMA: The Journal of the American Medical Association 265, no. 5 (1991): 652. http://dx.doi.org/10.1001/jama.1991.03460050106033.

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Mitchell, Mark L. "Biostatistics in Clinical Medicine." JAMA: The Journal of the American Medical Association 272, no. 4 (1994): 318. http://dx.doi.org/10.1001/jama.1994.03520040080048.

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Burden, A. C. "Clinical Epidemiology and Biostatistics." Postgraduate Medical Journal 66, no. 775 (1990): 415. http://dx.doi.org/10.1136/pgmj.66.775.415.

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Cox, Terry A. "Biostatistics in Clinical Medicine." American Journal of Ophthalmology 104, no. 2 (1987): 198. http://dx.doi.org/10.1016/0002-9394(87)90029-8.

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Dissertations / Theses on the topic "Clinical biostatistics"

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Zhang, Yifan. "Bayesian Adaptive Clinical Trials." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070079.

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Bayesian adaptive designs are emerging as popular approach to develop adaptive clinical trials. In this dissertation, I describe the mathematical steps for computing the theoretical optimal adaptive designs in biomarker-integrated trials and in trials with survival outcomes. Section 1 discusses the optimal design in personalized medicine. The optimal design maximizes the expected trial utility given any pre-specified utility function, though the discussion here focuses on maximizing responses within a given patient horizon. This work provides absolute benchmark for the evaluation of trial des
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White, Richard. "Novel Statistical Methods Applied in Clinical Trials and Gut Microbiota." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10587.

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Ethical clinical trials need both societal and personal equipoise. Recently, personal equipoise has been disturbed by the introduction of interim analyses; after an interim analysis has been performed the study administrators have additional information about the treatments, which is withheld from new recruits. For true informed consent, this information should be given to new study recruits to use in making a personal decision about their desired treatment. We present a method (and the rationale behind the method) that provides unbiased estimates of hazard ratios when new recruits are given i
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Kittelson, John Martin. "The design of group sequential clinical trials." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290621.

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Group sequential clinical trials have become the accepted method for monitoring the results of an ongoing trial. These methods allows early termination of a trial based on the results of "interim analyses" that are conducted after each of the groups of subjects are entered on the study. Existing methods for designing these types of trials are currently comprised of several different constructions, each of which addresses a different clinical setting. The purpose of this dissertation is to unify these constructions into a single framework. This is accomplished by first proposing a general algeb
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Sharkey, Brian Joseph. "Statistical Methods for the Assessment of Safety and Efficacy in HIV Clinical Trials." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10903.

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Evaluation of different treatments for HIV should take into account the relative balance of safety and efficacy for each treatment. Often time in HIV clinical trials the primary efficacy outcome measure is time to virologic failure, analyzed in an intention-to-treat manner ignoring the changes from the randomized regimens which occur in a reasonable proportion of study participants, often due to treatment limiting adverse events. Clinically, there is therefore considerable interest in also comparing regimens with respect to the competing outcomes of virologic failure and treatment-limiting adv
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Tromp, Mary. "Bayesian monitoring of clinical trials| Examples using conjugate priors." Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1583226.

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<p> A clinical trial can save time and resources if it incorporates Bayesian monitoring. Generally speaking, conducting Bayesian analysis is a computationally intensive task. However, in the special case of hypotheses testing for clinical trials, and, moreover, when conjugate prior distributions of parameters are used, computational complexity is reduced remarkably. This thesis presents three examples where the Bayesian monitoring is achieved with a prior density of a parameter and the likelihood function of the data belonging to conjugate families of distributions. The first example studies a
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Rodella, Stefania. "Exploring reliability in epidemiology and clinical research." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23421.

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Quality of measurement is a fundamental issue in medical research and clinical practice, of relevance for any inference or decision-making process. Reliability, as an estimate of the variability in the domain of repeated measurements, is an important component of the quality of measurements.<br>Reliability indices are frequently used and presented in the medical literature and a considerable amount of methodological research has been conducted on this topic in the last decades. However, the debate is still open on some theoretical and operational aspects. Available knowledge concerning reliabi
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Li, Shuli. "Estimating and Testing Treatment Effects and Covariate by Treatment Interaction Effects in Randomized Clinical Trials with All-or-Nothing Compliance." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10554.

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In this dissertation, we develop and evaluate methods for adjusting for treatment non-compliance in a randomized clinical trial with time-to-event outcome within the proportional hazards framework. Adopting the terminology in Cuzick et al. [2007], we assume the patient population consists of three (possibly) latent groups: the ambivalent group, the insisters and the refusers, and we are interested in analyzing the treatment effect, or the covariate by treatment interaction effect, within the ambivalent group. In Chapter 1, we propose a weighted per-protocol (Wtd PP) approach, and motivated by
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Peng, Zhimin. "The Role of Missing Data Imputation in Clinical Studies." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535705430538222.

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Tamblyn, Robyn M. "The use of the standardized patient in the measurement of clinical competence : the evaluation of selected measurement properties." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74219.

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The standardized patient is one method which can be used in the measurement of clinical competence. The accuracy of reproduction of important features of the patient case by the standardized patient was evaluated in Studies 1 and 2. In 839 encounters reviewed, only 13/89 patients provided an accurate reproduction of the case. Attributes of the patient, training process and evaluation procedure were associated with better patient accuracy. A significant inverse relationship was found between patient accuracy and competence score. In Study 3, the use of standardized patients as raters of behavio
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Matoušů, Barbora. "Incidenční a prevalnční onemocnění v okrsní nemocnici v průběhu 3 let." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-3969.

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Branches of science such as epidemiology, clinical epidemiology, statistics and various statistical methods are by ground for activity of epidemiological-manager indicators. Incidence and prevalence are numbered among epidemiological-manager indicators. In condition of hospital Pelhřimov are these indicators written, analyzed and predicated for department of hospitalized in years 2005 -- 2007. At the same time is appraised use of capacities department of hospitalized, is made analyse and estimation of most often treated diagnosis and is watched progress their average time of treatment. The wat
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Books on the topic "Clinical biostatistics"

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G, Trapp Robert, ed. Basic & clinical biostatistics. 2nd ed. Prentice-Hall International, 1994.

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G, Trapp Robert, ed. Basic & clinical biostatistics. 4th ed. Lange Medical Books/McGraw-Hill, Medical Pub. Division, 2004.

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Dawson, Beth. Basic and clinical biostatistics. Prentice-Hall International, 1990.

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Dawson, Beth. Basic and clinical biostatistics. Appleton & Lange, 1990.

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Knapp, Rebecca Grant. Clinical epidemiology and biostatistics. Williams & Wilkins, 1992.

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Kramer, Michael S. Clinical Epidemiology and Biostatistics. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61372-2.

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Missing data in clinical studies. John Wiley & Sons, Ltd, 2007.

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Clinical trial biostatistics and biopharmaceutical applications. CRC Press, 2015.

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Goodman, Melody S. Biostatistics for Clinical and Public Health Research. Routledge, 2017. http://dx.doi.org/10.4324/9781315155661.

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L, Adeney Kathryn, Weiss Noel S. 1941-, and Shoben Abigail B, eds. Epidemiology and biostatistics: An introduction to clinical research. Springer, 2009.

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Book chapters on the topic "Clinical biostatistics"

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Marchenko, Olga V., Lisa M. LaVange, and Natallia V. Katenka. "Biostatistics in Clinical Trials." In Quantitative Methods in Pharmaceutical Research and Development. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48555-9_1.

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Kramer, M. S. "Clinical Biostatistics: An Overview." In Principles and Practice of Research. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-0371-8_15.

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Roy, Gaurav, Atanu Bhattacharjee, and Iqra Khan. "Biostatistics in Clinical Oncology." In 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1067-0_14.

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Kramer, Michael S. "Clinical Trials." In Clinical Epidemiology and Biostatistics. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61372-2_7.

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Wassertheil-Smoller, Sylvia. "Mostly about Clinical Trials." In Biostatistics and Epidemiology. Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4757-2424-0_6.

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Wassertheil-Smoller, Sylvia, and Jordan Smoller. "Mostly About Clinical Trials." In Biostatistics and Epidemiology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2134-8_6.

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Wassertheil-Smoller, Sylvia. "Mostly about Clinical Trials." In Biostatistics and Epidemiology. Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4757-3887-2_5.

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Garhöfer, Gerhard, and Leopold Schmetterer. "Epidemiology and Biostatistics." In Clinical Pharmacology: Current Topics and Case Studies. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27347-1_14.

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Rosner, Gary L., Purushottam W. Laud, and Wesley O. Johnson. "Clinical Trial Designs." In Bayesian Thinking in Biostatistics. Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781439800102-13.

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Kestenbaum, Bryan. "General Considerations in Clinical Research Design." In Epidemiology and Biostatistics. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-88433-2_2.

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