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Journal articles on the topic 'Clinical Chorioamnionitis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Westover, Thomas, and Robert A. Knuppel. "Modern Management of Clinical Chorioamnionitis." Infectious Diseases in Obstetrics and Gynecology 3, no. 3 (1995): 123–32. http://dx.doi.org/10.1155/s1064744995000457.

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Clinical chorioamnionitis continues to contribute to fetal and maternal morbidity and mortality. Significant advances have been made in the last 20 years in understanding the pathophysiologic processes leading to chorioamnionitis. This review addresses the history, incidence, pathophysiology, host defenses, risk factors, diagnosis, and maternal and neonatal management of clinically evident chorioamnionitis. After a detailed review of the physiologic processes leading to clinical chorioamnionitis and sepsis, we present a modern management scheme designed to optimize perinatal outcome for both m

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Asogwa, Augustine O., Euzebus C. Ezugwu, George Uchenna Eleje, et al. "Association of Clinical Signs of Chorioamnionitis with Histological Chorioamnionitis and Neonatal Outcomes in Women with Premature Rupture of Membranes." Nigerian Journal of Clinical Practice 26, no. 9 (2023): 1354–60. http://dx.doi.org/10.4103/njcp.njcp_128_23.

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ABSTRACT Background: Premature rupture of membrane (PROM), especially when preterm or prolonged is associated with an increased risk of chorioamnionitis with its attendant feto-maternal complications. Aim: The study was aimed to determine the association of clinical signs of chorioamnionitis with histological chorioamnionitis and neonatal outcomes in women with PROM. Materials and Methods: Eligible participants with clinical diagnosis of PROM at gestational age of ≥28 weeks managed between December 2018 and June 2019 were consecutively recruited. Their sociodemographic characteristics, obstetr

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Ioannis, K. Thanasas. "Chorioamnionitis." Merit Research Journal of Medicine and Medical Sciences 6, no. 12 (2018): 416–25. https://doi.org/10.5281/zenodo.2536541.

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Chorioamnionitis is a serious complication of the pregnancy. The ascending microbial infection from the vagina to the amniotic cavity, seems to be the main mechanism of causing an intra-amniotic infection. The most common microbes are the E Coli, aerobic and anaerobic streptococcus, anaerobic staphylococcus and the bacteria that are responsible for sexually transmitted diseases. Diagnosis of chorioamnionitis is challenging, as clinical signs and symptoms are not specific. Fever is a dominant clinical feature, followed by maternal and fetal tachycardia, sensitivity to the uterine palpation, odo

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Spiegel, Ariana M., Jingjing Li, John W. Oehlert, et al. "A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants." American Journal of Perinatology 36, no. 14 (2019): 1453–58. http://dx.doi.org/10.1055/s-0038-1677503.

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Objective To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. Study Design We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative records. There were 213 clinical chorioamnionitis cases and 707 clinically uninfected controls. We compared demographic and clinical outcomes of cases and controls. We performed a GWAS and compared the distribution of SNPs from the background genes and from the immunome genes. We used

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Nakayama, M., H. Arai, M. Takeuchi, T. Takeshima, and A. Miyano. "Chorioamnionitis and its clinical significance." Placenta 19, no. 7 (1998): A26. http://dx.doi.org/10.1016/s0143-4004(98)91142-0.

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Gultekin-Elbir, Elif E., Catherine Ford, and Mehmet R. Genç. "The value of amniotic fluid analysis in patients with suspected clinical chorioamnionitis." Journal of Perinatal Medicine 47, no. 5 (2019): 493–99. http://dx.doi.org/10.1515/jpm-2018-0306.

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Abstract Objective To assess the value of incorporating amniotic fluid (AF) analysis in the management of patients with clinical chorioamnionitis. Methods This was a retrospective cohort study of all women carrying a singleton fetus and managed at our center between 2000 and 2009. We included only those women suspected of chorioamnionitis based on one or more of the following: (1) uterine tenderness, (2) maternal fever, (3) maternal and/or fetal tachycardia and (4) purulent discharge. The management was deemed to be justified if (1) pregnancy was terminated <24 weeks and histology confirmed

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Randis, Tara M., Madeline Murguia Rice, Leslie Myatt, et al. "Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis." Journal of Perinatal Medicine 46, no. 8 (2018): 926–33. http://dx.doi.org/10.1515/jpm-2017-0192.

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Abstract Objective To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. Methods We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the “clinical diagnosis” of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause. Early-onset neonatal sepsis was categorized as “suspected” or “confirme

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Galinsky, Robert, Graeme R. Polglase, Stuart B. Hooper, M. Jane Black, and Timothy J. M. Moss. "The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development." Journal of Pregnancy 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/412831.

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Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclinical/histologic chorioamnionitis, which is asymptomatic and defined by inflammation of the chorion, amnion, and placenta. Chorioamnionitis is often associated with a fetal inflammatory response. The fetal inflammatory response syndrome (FIRS) is defined by increased systemic inflammatory cytokine co

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Taşın, Cuma, and Ayhan Coşkun. "The importance of C-reactive protein and procalcitonin in the diagnosis of chorioamnionitis in the cases with preterm premature rupture of membranes." Perinatal Journal 28, no. 3 (2020): 190–95. http://dx.doi.org/10.2399/prn.20.0283010.

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Objective: Our aim is to compare the clinical biochemical markers of the cases who developed and did not develop clinical chorioamnionitis among those hospitalized in our clinic with the diagnosis of preterm premature rupture of membranes (PPROM). For that purpose, we investigated the significance levels of mean values, sensitivity and specificity levels of the infection markers and also their correlations with each other in the diagnosis of clinical chorioamnionitis. Methods: Eighty-one cases with singleton pregnancy who were hospitalized with the pre-diagnosis of PPROM and followed up and tr

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Tan, Jia Yee, Hannah Xin Yi Yeoh, Wai Kit Chia, et al. "Overexpression of Connexin 40 in the Vascular Endothelial Cells of Placenta with Acute Chorioamnionitis." Diagnostics 14, no. 8 (2024): 811. http://dx.doi.org/10.3390/diagnostics14080811.

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Background: Connexins (Cx) 43 and 40 play a role in leukocytes recruitment in acute inflammation. They are expressed in the endothelial cells. They are also found in the placenta and involved in the placenta development. Acute chorioamnionitis is associated with an increased risk of adverse perinatal outcomes. The aim of this study was to determine the expressions of Cx43 and Cx40 in the placenta of mothers with acute chorioamnionitis, and to correlate their association with the severity of chorioamnionitis and adverse perinatal outcomes. Methods: This study comprised a total of 81 cases, cons

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Carter, Sean W. D., Samantha Neubronner, Lin Lin Su, et al. "Chorioamnionitis: An Update on Diagnostic Evaluation." Biomedicines 11, no. 11 (2023): 2922. http://dx.doi.org/10.3390/biomedicines11112922.

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Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and va

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Wong, Yin Ping, Noorhafizah Wagiman, Jonathan Wei De Tan, et al. "Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes." Diagnostics 12, no. 4 (2022): 882. http://dx.doi.org/10.3390/diagnostics12040882.

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Background: Chorioamnionitis complicates about 1–5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of CXCR1 in placentas with chorioamnionitis, and its association with adverse perinatal outcomes. Methods: A total of 101 cases of chorioamnionitis and 32 cases of non-chorioamnionitis were recruited over a period of 2 years. CXCR1 immunohistochemistry was performed, and its immunoexpression in placentas was evaluated. The adverse perina

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Afza, Nilufar Shameem, Waheeda Nargis, Borhan Uddin Ahamed, and Nazmul Haq Sikder. "The Incidence, Risk Factors and Common Foetal outcome of Chorioamnionitis in Women with Preterm Premature Rupture of Membrane (PPROM): A Single Centre Study." Bangladesh Journal of Obstetrics & Gynaecology 26, no. 1 (2013): 10–19. http://dx.doi.org/10.3329/bjog.v26i1.13752.

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Background and objective: The objective of this study was to detect the incidence of chorioamnionitis in PPROM and to evaluate the pattern of foetal outcome in these cases at a tertiary care hospital in Bangladesh. This study is also aimed to analyze the influence of the demographic variables predisposing to chorioamnionitis in PPROM in a locality. Materials and Methods: This single centre cross-sectional study was conducted on 110 pregnant women with preterm rupture of membranes at a tertiary care hospital in Dhaka, Bangladesh. The study group was divided according to the presence or absence

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Garmi, Gali, Marina Okopnik, Yoram Keness, Noah Zafran, Elad Berkowitz, and Raed Salim. "Correlation between Clinical, Placental Histology and Microbiological Findings in Spontaneous Preterm Births." Fetal Diagnosis and Therapy 40, no. 2 (2015): 141–49. http://dx.doi.org/10.1159/000441518.

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Aims: To examine the occurrence of chorioamnionitis and abruption among women who had a spontaneous preterm birth (SPTB), the correlation between clinical and placental findings, and the impact of these complications on neonatal outcome after delivery. Methods: This was a retrospective case-control study conducted between 2008 and 2012 at a single teaching hospital. The study group included all women who had an SPTB (23-36 weeks). Placentas were cultured and underwent histological examination. Results: A total of 478 women were included. The mean gestational age at delivery was 32.6 ± 3.1 week

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Ji, Hongxiu, Margie Bridges, Elizabeth Pesek, Kristin Graham, Lennart Tan, and Shilpi Chabra. "Acute Funisitis Correlates With the Risk of Early-Onset Sepsis in Term Newborns Assessed Using the Kaiser Sepsis Calculator." Pediatric and Developmental Pathology 22, no. 6 (2019): 523–31. http://dx.doi.org/10.1177/1093526619855467.

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Background The risk of neonatal early-onset sepsis (EOS) is traditionally assessed on maternal signs of clinical chorioamnionitis. Recently, an online EOS risk calculator was developed by Kaiser Permanente using maternal and neonatal clinical parameters. We were interested in whether an increased Kaiser sepsis risk score correlates with histologic acute chorioamnionitis or acute funisitis. Design Included in this retrospective review are 119 chorioamnionitis-exposed term neonates from January 1, 2015 and December 31, 2016. Clinical charts from mother–baby pairs were reviewed. An EOS risk score

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Mazaki-Tovi, Shali, and Edi Vaisbuch. "Clinical chorioamnionitis – an ongoing obstetrical conundrum." Journal of Perinatal Medicine 44, no. 1 (2016): 1–4. http://dx.doi.org/10.1515/jpm-2015-0366.

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SMULIAN, JOHN C., SUSAN SHEN-SCHWARZ, ANTHONY M. VINTZILEOS, MARIAN F. LAKE, and CANDE V. ANANTH. "Clinical Chorioamnionitis and Histologic Placental Inflammation." Obstetrics & Gynecology 94, no. 6 (1999): 1000–1005. http://dx.doi.org/10.1097/00006250-199912000-00018.

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Smulian, J. "Clinical chorioamnionitis and histologic placental inflammation." Obstetrics & Gynecology 94, no. 6 (1999): 1000–1005. http://dx.doi.org/10.1016/s0029-7844(99)00416-0.

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Zackler, Alyssa, Rori Dajao, Pamela Flood, and Laura Goetzl. "121: Clinical chorioamnionitis and uterine contractility." American Journal of Obstetrics and Gynecology 212, no. 1 (2015): S78. http://dx.doi.org/10.1016/j.ajog.2014.10.167.

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Gibbs, Ronald S. "Management of clinical chorioamnionitis at term." American Journal of Obstetrics and Gynecology 191, no. 1 (2004): 1–2. http://dx.doi.org/10.1016/j.ajog.2004.03.026.

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21

Tita, Alan T. N., and William W. Andrews. "Diagnosis and Management of Clinical Chorioamnionitis." Clinics in Perinatology 37, no. 2 (2010): 339–54. http://dx.doi.org/10.1016/j.clp.2010.02.003.

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Tajiri, Ryosuke, Emi Kondo, Shinichi Uchiyama, et al. "Clinical Background of Pathologically Diagnosed Chorioamnionitis." Placenta 141 (September 2023): 94. http://dx.doi.org/10.1016/j.placenta.2023.08.030.

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23

Bambani, Taniqsha, and Noopur Ramesh Kedia. "The Adverse Outcomes of Chorioamnionitis on the Pregnant Female and Their Fetus." International Journal of Research and Review 10, no. 12 (2023): 499–506. http://dx.doi.org/10.52403/ijrr.20231254.

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Introduction: Chorioamnionitis is an intra-amniotic infection caused by an ascending polymicrobial bacterial infection. Triple I (intrauterine inflammation or infection or both) is also proposed to replace chorioamnionitis due to its imprecise definition and variable clinical manifestations. Intraamniotic infection is characterized by inflammation of the amniotic fluid, placenta, fetus, fetal membranes, or decidua. Maternal fever, uterine tenderness, maternal tachycardia, fetal tachycardia, and purulent fluid coming from the cervical os (the cervical opening can be external, near the vagina, o

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Romero, Roberto, Percy Pacora, Juan Pedro Kusanovic, et al. "Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia – implications for clinical care." Journal of Perinatal Medicine 49, no. 3 (2021): 275–98. http://dx.doi.org/10.1515/jpm-2020-0297.

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Abstract Objectives Clinical chorioamnionitis at term is considered the most common infection-related diagnosis in labor and delivery units worldwide. The syndrome affects 5–12% of all term pregnancies and is a leading cause of maternal morbidity and mortality as well as neonatal death and sepsis. The objectives of this study were to determine the (1) amniotic fluid microbiology using cultivation and molecular microbiologic techniques; (2) diagnostic accuracy of the clinical criteria used to identify patients with intra-amniotic infection; (3) relationship between acute inflammatory lesions of

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Jang, Il-Yeo, Hye-Ji Jung, Ji-Hee Sung, et al. "Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?" Diagnostics 12, no. 9 (2022): 2126. http://dx.doi.org/10.3390/diagnostics12092126.

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Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21+0 and 31+6 week of gestation due to preterm labor (PTL, n = 165), preterm premature rupture of membranes (PPROM, n = 202), or incompetent internal os of the cervix (IIOC, n = 44). The primary outcome measure was the rate of severe histological chorioamnionitis/funisitis. Secondary outcome measure was neonatal outcomes including neonatal and infant deat

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Martingano, Daniel, Shailini Singh, and Antonina Mitrofanova. "Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens." Infectious Diseases in Obstetrics and Gynecology 2020 (July 9, 2020): 1–8. http://dx.doi.org/10.1155/2020/2093530.

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Objective. To determine if antibiotic regimens including azithromycin versus erythromycin has an impact on pregnancy latency and development of clinical chorioamnionitis in the context of preterm prelabor rupture of membranes. Study Design. We conducted a prospective observational cohort study and followed all women receiving antibiotic regimens including either azithromycin or erythromycin in the context of preterm prelabor rupture of membranes. Primary outcomes were the duration of pregnancy latency period and development of chorioamnionitis. Secondary outcomes included neonatal sepsis with

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JESSOP, F., and NJ SEBIRE. "HISTOLOGICAL CHORIOAMNIONITIS: CURRENT CONCEPTS OF DIAGNOSIS, CLASSIFICATION AND CLINICAL SIGNIFICANCE." Fetal and Maternal Medicine Review 22, no. 1 (2011): 25–44. http://dx.doi.org/10.1017/s0965539511000015.

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Interest in the clinical associations between maternal intrapartum fever and adverse neonatal outcome has been longstanding, with publications of a relationship between maternal fever and cerebral palsy dating from the 1950s. Further recognition of the associations between either clinically or histologically characterised chorioamnionitis, ascending infection and neonatal wellbeing followed, with numerous reports in the 1960s and 70s, particularly as the neonatal significance of group B streptococcal infections became apparent. Similarly, with the systematic introduction of diagnostic light mi

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Islam, Mitheel Ibna, Monowara Khatun, Md Shahidul Islam, Md Nurul Amin, and Shitil Ibna Islam. "Association between C - reactive protein and Premature Rupture of Membrane." Ibrahim Cardiac Medical Journal 4, no. 2 (2016): 26–31. http://dx.doi.org/10.3329/icmj.v4i2.52988.

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Background and Objectives: Early diagnosis of clinical chorioamnionitis (ChAm) in patients with premature rupture of membrane (PROM) is essential for its prompt treatment with antibiotics. Amniocentesis may be used to detect subclinical infections in cases of PROM. But the procedure is an invasive one. The present study was undertaken to study the role of plasma C-reactive protein (CRP) in the prediction of clinical chorioamnionitis in case of PROM. Materials & Methods The cross-sectional study was carried out in the of Departments of Obstetrics & Gynaecology, Khulna Medical Coll

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Rovira, Nuria, Ana Alarcon, Marti Iriondo, et al. "Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants." Early Human Development 87, no. 4 (2011): 253–57. http://dx.doi.org/10.1016/j.earlhumdev.2011.01.024.

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Lin, Qingqing, Yanchen Wang, Ying Huang, et al. "Association of Antenatal Corticosteroids with Neonatal Outcomes among Very Preterm Infants Born to Mothers with Clinical Chorioamnionitis: A Multicenter Cohort Study." Children 11, no. 6 (2024): 680. http://dx.doi.org/10.3390/children11060680.

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The objective of this study was to assess the relationship of ACS with neonatal outcomes among very preterm infants born to mothers with clinical chorioamnionitis in China. This was a multicenter retrospective cohort study. Study participants included infants born at <32 weeks’ gestation with clinical chorioamnionitis and registered in the Chinese Neonatal Network from 1 January 2019 to 31 December 2020. Infants were divided into two groups: any amount of ACS or no administration of ACS. Multivariable generalized linear models using generalized estimating equations were used to assess the a

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Kravtsova, O. N. "Chorioamnionitis: unresolved diagnostic issues." Practical medicine 23, no. 2 (2025): 14–20. https://doi.org/10.32000/2072-1757-2025-2-14-20.

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Chorioamnionitis (CA) is a risk factor for obstetric and perinatal infectious complications. The diagnosis of CA is based on clinical criteria, which vary depending on the professional community. Modern microbiological methods, the amniotic fluid analysis and the diagnostic search aimed at fetal condition are promising areas for improving the CA diagnosis.

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Kiyoshima, Chihiro, Naoto Shirasu, Daichi Urushiyama, et al. "MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis." Future Science OA 7, no. 5 (2021): FSO686. http://dx.doi.org/10.2144/fsoa-2021-0006.

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Background: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. Materials & methods: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc’s criteria. Results: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for sev

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&NA;. "Recurrence of Clinical Chorioamnionitis in Subsequent Pregnancies." Obstetric Anesthesia Digest 27, no. 3 (2007): 132. http://dx.doi.org/10.1097/01.aoa.0000288262.90306.87.

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Laibl, Vanessa R., Jeanne S. Sheffield, Scott Roberts, Donald D. McIntire, and George D. Wendel. "Recurrence of Clinical Chorioamnionitis in Subsequent Pregnancies." Obstetrics & Gynecology 108, no. 6 (2006): 1493–97. http://dx.doi.org/10.1097/01.aog.0000247647.88489.b0.

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Fishman, Shira G., and Shari E. Gelber. "Evidence for the clinical management of chorioamnionitis." Seminars in Fetal and Neonatal Medicine 17, no. 1 (2012): 46–50. http://dx.doi.org/10.1016/j.siny.2011.09.002.

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Laibl (F), Vanessa, Jeanne Sheffield, Scott Roberts, Donald Mcintire, and George Wendel. "Recurrence of clinical chorioamnionitis in subsequent pregnancies." American Journal of Obstetrics and Gynecology 193, no. 6 (2005): S190. http://dx.doi.org/10.1016/j.ajog.2005.10.770.

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Sperling, M. M., L. Sie, A. Girsen, S. A. Leonard, and R. Gibbs. "Risk of recurrent clinical chorioamnionitis in California." American Journal of Obstetrics and Gynecology 223, no. 6 (2020): 983. http://dx.doi.org/10.1016/j.ajog.2020.08.167.

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Sai Aparna, Pentala, Vaishali Taralekar, and Suchita Dabhadkar. "Evaluation of CRP as Predictor of Chorioamnionitis in Premature Rupture of Membranes." Indian Journal of Obstetrics and Gynecology 11, no. 3 (2023): 9–17. http://dx.doi.org/10.21088/ijog.2321.1636.11323.1.

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Background: Early identification of sepsis is essential as the mother has a risk of chorioamnionitis. C-reactive protein levels are done along with placental histopathology to detect chorioamnionitis. It is one of the most significant causes of high perinatal morbidity and mortality. Aim and Objective: To determine c-reactive protein levels and placental histopathology in premature rupture of membranes for maternal chorioamnionitis. Methodology: A prospective study was conducted in a tertiary care university medical college hospital and research center in western Maharashtra. A total of 250 pr

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Ayrapetyan, Marina, David Carola, Satyan Lakshminrusimha, Vineet Bhandari, and Zubair Aghai. "Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics." American Journal of Perinatology 36, no. 04 (2018): 428–33. http://dx.doi.org/10.1055/s-0038-1668548.

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Objective To evaluate variations in practice for the management of neonates born to mothers with clinical chorioamnionitis. Methods This was a prospective cross-sectional survey consisting of 10 multiple choice questionnaires distributed to 2,900 members of the Perinatal Section of American Academy of Pediatrics. Variations in responses were assessed and compared between the various groups. Results A total of 682 members (23.5%) completed the survey; 169 (24.8%) indicated that they use the neonatal early-onset sepsis (EOS) risk calculator for the management of neonates born to mothers with cli

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Wiwanitkit, Viroj. "Maternal C-Reactive Protein for Detection of Chorioamnionitis: an Appraisal." Infectious Diseases in Obstetrics and Gynecology 13, no. 3 (2005): 179–81. http://dx.doi.org/10.1080/10647440500068321.

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Premature delivery is still a significant problem in obstetrics, and chorioamnionitis is an unwelcome complication. C-reactive protein (CRP) is a circulating marker of low-grade inflammation and the role of its measurement in clinical practice remains unclear for many conditions. It has been claimed that estimation of CRP is helpful in the diagnosis of chorioamnionitis, and this study aims to appraise such claims. Following review of the literature, six reports were recruited for further metanalysis, including 466 cases. The overall prevalence of chorioamnionitis was 41% (191/466). The overall

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Denzler, Annick, Tilo Burkhardt, Giancarlo Natalucci, and Roland Zimmermann. "Latency after Preterm Prelabor Rupture of the Membranes: Increased Risk for Periventricular Leukomalacia." Journal of Pregnancy 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/874984.

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Objective. To identify the risk factors for cystic periventricular leukomalacia (cPVL) and their implications for deciding between immediate delivery and conservative management of preterm prelabor rupture of the membranes (pPROM).Methods. The following risk factors were compared between cPVL infants and 6440 controls: chorioamnionitis, sex, gestational age (GA), birth weight, pPROM, and pPROM-delivery interval. Factor impact on cPVL risk and clinical decision-making was determined by multivariate logistic regression.Results. Overall cPVL prevalence (n=32) was 0.99/1000 births. All cPVL infant

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Monga, Manju, and Jorge D. Blanco. "Intrauterine Infection and Preterm Labor." Infectious Diseases in Obstetrics and Gynecology 3, no. 1 (1995): 37–44. http://dx.doi.org/10.1155/s1064744995000287.

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Preterm birth remains the leading cause of perinatal mortality and morbidity. Evidence suggests that intrauterine infection plays an important role in the pathogenesis of preterm labor. This article reviews the clinical data supporting this theory and the cellular and biochemical mechanisms by which intrauterine infection may initiate uterine contractions. The clinical and laboratory methods of diagnosing clinical chorioamnionitis and asymptomatic bacterial invasion of the intraamniotic cavity are also reviewed. Finally, the management of clinical chorioamnionitis and asymptomatic microbial in

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Cooney, Laura G., and Jamie A. Bastek. "The Association between Early Artificial Amniotomy and Chorioamnionitis in Nulliparous Induction of Labor." International Scholarly Research Notices 2014 (December 16, 2014): 1–8. http://dx.doi.org/10.1155/2014/628452.

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Objectives. To investigate whether early artificial amniotomy (AROM) <4 cm in nulliparous women admitted for induction of labor was associated with an increased rate of chorioamnionitis and cesarean section or a decreased time to vaginal delivery. Study Design. A retrospective cohort study was performed on nulliparous women with a term, singleton gestation and intact membranes who presented for induction of labor (January 2008 to December 2011). Chorioamnionitis was defined using ICD9 codes. Results. 1,567 women were enrolled; 25.4% underwent early AROM. Overall, the prevalence of chorioamn

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Aggarwal, Amika, and Sangeeta Pahwa. "Evaluation of the role of CRP as an early predictor of chorioamnionitis in PPROM." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 4 (2018): 1351. http://dx.doi.org/10.18203/2320-1770.ijrcog20181037.

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Background: Preterm birth is one of the most important cause of perinatal morbidity and mortality. PROM is defined as spontaneous rupture of membranes before the onset of uterine contraction. Objective of present study was to evaluate the role of CRP as an early predictor of Chorioamnionitis in PPROM.Methods: A prospective study was done on 50 cases with PPROM and 50cases of control group without PPROM. All mothers and babies were observed from the time of admission to the time of discharge.Results: C-reactive protein appears to be the most sensitive acute phase protein; rising of less than 24

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Shevareva, Ekaterina A., Alevtina M. Savicheva, Larisa A. Fedorova, Kira V. Shalepo, Galina V. Grinenko, and Oksana V. Nevmerzhitskaia. "Risks of microbial colonization in newborn born to mothers with chorioamnionitis." Pediatrician (St. Petersburg) 13, no. 4 (2022): 29–40. http://dx.doi.org/10.17816/ped13429-40.

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BACKGROUND: Chorioamnionitis, or intra-amniotic infection, is an infection of the membranes and amniotic cavity caused by polymicrobial associations, including Streptococcus agalactiae (SGB), predominantly localised to the lower genital tract of women. The colonization of a infant with GBS occurs as a result of ascending infection from the mother, in the intranatal period during passage through the natural birth canal of the mother. Colonization of the skin and mucous membranes of the infant in the vast majority of cases proceeds without the clinical implementation of the infectious process, o

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Onyi Asiji Nwogu. "Implementation of aseptic technique training and assessment to reduce the incidence of chorioamnionitis in laboring patients." International Journal of Science and Research Archive 6, no. 2 (2022): 110–14. http://dx.doi.org/10.30574/ijsra.2022.6.2.0159.

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Chorioamnionitis may significantly affect the outcome of positive birth experiences for expecting mothers. The purpose of this quantitative, quasi-experimental quality improvement project was to determine if the implementation of the University of Michigan’s Assessment Tool for Aseptic Technique and Assessment would impact the rate of maternal chorioamnionitis among laboring women admitted in a labor and delivery unit in a local Californian hospital over 30 days. Neuman’s system theory, Watson’s caring theory, and the plan, do, study, act (PDSA) cycle were the theoretical and conceptual underp

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Conde-Agudelo, A., R. Romero, E. J. Jung, and A. J. G. Sánchez. "Management of Clinical Chorioamnionitis: An Evidence-based Approach." Obstetric Anesthesia Digest 41, no. 3 (2021): 112–13. http://dx.doi.org/10.1097/01.aoa.0000766000.82939.bc.

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Gugino, Lawrence J., Paul T. Buerger, Jean Wactawski-Wende, and John Fisher. "Chorioamnionitis: the association between clinical and histological diagnosis." Primary Care Update for OB/GYNS 5, no. 4 (1998): 148. http://dx.doi.org/10.1016/s1068-607x(98)00026-2.

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Conde-Agudelo, Agustin, Roberto Romero, Eun Jung Jung, and Ángel José Garcia Sánchez. "Management of clinical chorioamnionitis: an evidence-based approach." American Journal of Obstetrics and Gynecology 223, no. 6 (2020): 848–69. http://dx.doi.org/10.1016/j.ajog.2020.09.044.

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Romagano, Matthew P., Gabriella Pinho, Kaila Krishnamoorthy, Lea George, Shauna F. Williams, and Joseph Apuzzio. "Clinical Predictors of Histologic Chorioamnionitis at Term [06N]." Obstetrics & Gynecology 135 (May 2020): 147S. http://dx.doi.org/10.1097/01.aog.0000665580.57294.1f.

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