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Relevant bibliographies by topics / Clinical immunology / Dissertations / Theses

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Dissertations / Theses on the topic 'Clinical immunology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mullazehi, Mohammed. "Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100483.

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Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. Anti-CII can form surface-bound immune complexes (IC) in inflamed joints, which might intensify joint inflammation and destruction. In this thesis I have studied the functional effects of surface-bound anti-CII–containing IC in vitro and correlated the results to clinical parameters. Anti-CII IC induced TN

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2

Åhlin, Erik. "Functional Role of Immune Complexes in Rheumatic and Parasitic Diseases." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139529.

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Immune complexes (IC) have key pathological roles in both autoimmune and infectious diseases. In this thesis functional mechanisms behind IC-driven inflammation in rheumatic diseases and tropical infections have been studied, with special focus on the contribution of autoantibodies and cytokine-inducing properties of IC. In the autoimmune disease SLE, increased levels of IC-induced cytokines were associated with both increased classical complement activation and the occurrence of the autoantibodies anti-SSA and anti-SSB, both directed against RNA-associated antigens. In addition, complement ac

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3

Liebrich, Walter. "Expert evaluation of an on-line course in clinical immunology." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/96006.

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Thesis (MPhil)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: This assignment describes an evaluation by experts of an on-line course in Clinical Immunology offered to medical registrars and scientists as a supplement to a practical rotation. Because of a lack of agreement on what constitutes quality in e-learning and to avoid the customary focus on usability evaluation, an open-ended, interpretivist approach was used here which, while not entirely novel, was unusual in an e-learning environment. For this project it was decided to evaluate both content (subject matter) as well as in

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4

Sinclair, D. "Studies on the immunology and laboratory investigation of B cell neoplasia." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377178.

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5

Semple, Patricia Lynn. "The role of the cytolytic mediators, granulysin and perforin, in tuberculosis." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/12403.

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Includes bibliographical references (leaves 150-175).<br>Includes abstract.<br>Protective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be direc

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6

Hannocks, Melanie-Jane. "The effects of fibroblast growth factor-2 om human bone marrow cells." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/2836.

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7

Nundalall, Trishana. "CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25382.

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Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal diseases are major contributors to infant mortality. Additionally, Human Immunodeficiency Virus-1 (HIV) infections increase the risk of mortality. Current advances in Prevention of Mother-to-Child Transmission (PMTCT) have prevented HIV infections in almost 97% of infants being born to HIV-infected mothers. As a result there is an increasing number of H

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8

Breetzke, Aerin Olivia. "Vaginal microbial diversity of the genital tract of South African adolescent females." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24976.

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Young, reproductive-aged women are at highest risk of acquiring human-immunodeficiency virus (HIV). The Women's Initiative in Sexual Health (WISH) study was designed to investigate potential biological reasons for this high risk in HIV negative, South African adolescent females. Little is known about the 'normal' microbiome of this population. As such, the aim of this substudy was to quantify specific bacterial species (L. crispatus, L. jensenii, L. gasseri, L. iners, G. vaginalis and P. bivia) by quantitative real time PCR (qPCR) from adolescent female lateral vaginal wall swabs, and to asses

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9

Kiravu, Agano. "Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33812.

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Background. In some regions of Sub-Saharan Africa, up to 30% of newborns are born to mothers infected with human immunodeficiency virus (HIV). Maternal antiretroviral treatment (ART) has reduced vertical transmission to lower than 1%. Despite the success of prevention of mother-tochild transmission (PMTCT) programmes, a large number of children born to these mothers are exposed to HIV and antiretrovirals (ARVs) in utero yet remain uninfected. These individuals, known as children who are HIV-exposed and uninfected (cHEU), succumb to higher rates of disease morbidity compared to children who are

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10

Kroca, Michal. "Expansion of circulatory Vγ9Vδ2 T cells in tularemia and Pontiac fever, two intracellular bacterial diseases with widely different clinical expression". Doctoral thesis, Umeå University, Clinical Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84.

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<p>Although well established that human Vγ9Vδ2 T cells may expand in circulation during intracellular bacterial infections, most underlying studies included only a few cases and only some diseases had been studied so far. In tularemia, a severe invasive disease, only one patient had been described. Legionellosis, including the mild flue-like Pontiac disease caused by Legionella micdadei, had not been studied at all. The aim of the present thesis was to study the circulatory Vγ9Vδ2-T cell response in these two intracellular bacterial diseases. The number of cases included was large enough to dr

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11

Tengvall, Linder Maria. "Immunological mechanisms in atopic dermatitis : clinical and experimental studies /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3217-4/.

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12

Gustafsson, Lidström Charlotte. "Local Immune regulation in human pregnancy : with focus on decidual macrophages." Doctoral thesis, Linköpings universitet, Klinisk immunologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9985.

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During pregnancy, the woman carries a fetus partly foreign to her immune system, because of the expression of paternal antigens. Despite this, the fetus is normally tolerated and not rejected, as is often the case with organs in allogeneic transplantations. Systemic changes in maternal blood occur during pregnancy but, perhaps of greater importance, are changes in tissues locally in the uterus. The pregnant uterine endometrium, the decidua, is infiltrated by large numbers of leukocytes, mainly natural killer (NK) cells but also macrophages and T lymphocytes. Further, various cytokines are know

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13

Mpotje, Thabo Rantanta Victor. "The role of BATF2 during of experimental murine Schistosomiasis." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/26898.

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Schistosomiasis is one of the most debilitating tropical diseases with the potential to cause morbidity and mortality in infected populations unless well controlled. Current control measures are limited to treatment with praziquantel. A rather alarming situation given i) the inability of the drug to directly target the pathogenic eggs, ii) the emergence of praziquantel-resistant schistosomes, iii) the persistence of tissue fibro-proliferative destruction caused by the trapped parasite eggs, even after treatment. Intestinal and liver immunopathology are pathognomonic of schistosomiasis and gene

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14

Wilson, Daisy. "Frailty, sarcopenia and immunesenescence : shared mechanisms and clinical insights." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8257/.

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Frailty, the increased vulnerability of an individual to stressors, and sarcopenia, the loss of muscle mass with age, share many of the same clinical outcomes, associations and suggested pathophysiology. The pathophysiology of both conditions is incompletely characterised but it is postulated the immune system is central to development and propagation. 40 healthy young, 40 healthy older, and 37 frail older adults were recruited to three groups. A further 73 healthy young adults were recruited for ultrasound assessment of muscle. Ultrasound was reviewed as a diagnostic technique in the identifi

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15

Cooper, David Kempton Cartwright. "Clinical orthotopic and heterotopic heart transplantation: aspects of the University of Cape Town experience." Master's thesis, Faculty of Health Sciences, 1985. https://hdl.handle.net/11427/31770.

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16

Kitley, Joanna Louise. "A clinical/immunological neuromyelitis optica association study." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:274bb81c-edce-4f6f-8330-172659ba99fc.

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Neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) are associated with the disease-specific autoantibody aquaporin-4 (AQP4-Ab), which is thought to be pathogenic. Some NMO/NMOSD patients do not have this antibody and may have different clinical and immuno-pathological disease characteristics, but previous clinical NMO/NMOSD studies have been confounded by inclusion of such patients. To define better the characteristics of AQP4-Ab disease, disease course, outcomes and predictors of disability were investigated in 106 AQP4-Ab positive NMO/NMOSD patients from the UK and Japan. AQP4-Ab

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17

Moberg, Lisa. "The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4260.

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18

Mosala, Paballo Pertunia. "The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33872.

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Cysteinyl leukotrienes (cysLTs) are potent inflammatory lipid mediators that play a major role in the pathophysiology of inflammatory diseases. They signal primarily through cysteinyl leukotriene receptor-1 (cysLTR1) and have been reported to drive Th2 immune responses. Initiation and amplification of robust Th2 immune responses is crucial for conferring protective immunity to helminth (Schistosoma mansoni and Nippostrongylus brasiliensis) infection in mice. The role played by cysLTs in the development of protective immune responses to helminth infections is not well documented. Hence in the p

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19

Poswayo, Sibongiseni Kwakho Luntukazi. "The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32970.

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South Africa recently experienced a Listeriosis outbreak, which was responsible for over 180 deaths, caused by an intracellular, rod-shaped bacilli called Listeria monocytogenes (LM). LM can infect both phagocytic and non-phagocytic cell types and induces its uptake by expressing internalin A and B, then secretes listeriolysin O (LLO), a virulence factor forming pores on the phagosome membrane to escape into the cytosol. Macrophages can phagocytose invading pathogens and induce innate inflammatory responses. Production of cytokines and eicosanoids by antigen presenting cells activates the adap

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20

Kidzeru, Elvis Banboye. "The impact of myeloid derived suppressor cells on vaccine immunogenicity in South African HIV-infected and uninfected mothers and their infants." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20852.

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BACKGROUND: Each year over 4 million infants die from infections, of which many are vaccinepreventable. Young infants respond poorly to vaccines, but the basis of reduced immunity is controversial. We hypothesized that myeloid-derived suppressor cells (MDSC) that might be induced during gestation, would persist at birth leading to active suppression of infant-immune responses. OBJECTIVE: We evaluated the ontogeny of MDSC and the effect of MDSC on vaccine immunogenicity during early life in South African infants and mothers, and in HIVexposed uninfected (HEU) infants and HIV+ mothers. METHODS:

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21

Govender, Melissa. "Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni". Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24890.

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Keratinocytes represent the major cell type in the skin. During cutaneous leishmaniasis (CL) and schistosomiasis, the skin is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to produce IL-12. Additionally, keratinocytes at the site of L. major infection in C57BL/6 mice, were postulated to be the source of the IL-4. We investigated if IL-4/IL-13 signalling

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22

Nyangahu, Donald D. "Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25479.

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Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, we investigate the effect of preconception helminth infections on maternal and infant gut microbiota. For maternal antibiotic experiments, dams were fed vancomycin, polymyxin B, or both, in drinking water during gestation, nursing or gestation plus nursing, and their offspring microbiota analysed at 14 days of life, alongside immunity in the spleens. Off

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23

Jayakumar, Jaisubash. "The role of IL-4 receptor alpha in chronic allergic airway disease (AAD)." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3166.

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24

Njikan, Samuel Ayaba. "Correlates of risk of TB disease in infants with differential response to BCG vaccination." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12873.

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Includes bibliographical references.<br>Studying prospective immune correlates of risk of TB disease following BCG vaccination is an important first step towards determining correlates of protection against TB, which can be identified only in a placebo-controlled randomized controlled trial (RCT) of an effective vaccine. To study correlates of risk of TB disease, we collected and stored blood from healthy 10-week old infants vaccinated with BCG at birth. During two years of follow up, infants who developed lung TB were defined as cases, while those who did not develop TB disease were defined a

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25

Moyo, Thandeka. "The screening of neutralising antibodies against a resistant HIV-1 strain to identify novel epitopes." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13239.

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Includes bibliographical references.<br>Since the start of the HIV/AIDS pandemic in the 1980s, over 75 million individuals have been infected with the virus and it has been the cause of approximately 36 million deaths worldwide. With such a high morbidity and mortality in HIV-1 infected individuals, there is a need to find ways of controlling the disease. Development of an HIV-1 vaccine would help in the fight against HIV/AIDS. It is clear that other prevention strategies poorly reach vulnerable groups such as intravenous drug users and people living in war zones. More importantly, they genera

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26

Esra, Rachel. "The association between the oral and vaginal microbiome of young South African women." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31379.

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Bacterial vaginosis (BV) and periodontal disease (PD) are conditions characterised by reduction of healthy bacterial communities in the vaginal and oral microbiomes respectively. Both BV and PD are associated with an increased risk of preterm labour and negative birth outcomes, yet it is unknown whether PD and BV are independent risk factors or may be interrelated. Understanding the health risks associated with pregnancies in young women is critical for developing new preventative interventions and for informing guidelines. Current knowledge of what constitutes a healthy microbiome is largely

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Moshi, Noell Dominika. "Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11785.

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The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots and proliferation assays were used to identify immunodominant ESAT6 and CFP10 15mer peptides targeted by CD8 T cells in LTBI and TB donors. A multiparameter flow cytometry panel was designed and optimized to assess turnover, susceptibility to apoptosis and

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Harryparsad, Rushil. "Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20563.

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Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target

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Rautenbach, Stefan. "Peripheral inflammatory and regulatory immune changes in HIV positive to HIV positive renal transplant recipients." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29482.

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INTRODUCTION Since 2008, 43 renal transplants have been performed from HIV positive deceased donors to HIV positive recipients with renal failure predominantly due to HIV-associated Nephropathy (HIVAN). Recipients received Anti-thymocyte globulin (ATG) induction therapy and maintenance immunosuppression. Despite transplantation across Human Leukocyte Antigen (HLA) mismatches, there were few rejection events in the first year post-transplant (PT). Recipient CD4 counts did not decrease and HIV viral load also remained undetectable at one year PT. To gain insight into immune homeostatic mechanis

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30

Carlie, Gadija. "An in vitro investigation of the effect of Khellin and UVA (KUVA) on normal and transformed human melanocytes." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26931.

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The problematic and numerous side effects of PUVA (psoralen and UVA) and other treatments currently in use for vitiligo, have justified the search for an alternative treatment. In this study, the use of khellin, a naturally occurring furochromone, which is similar in structure to psoralens, is explored as an alternative treatment for vitiligo. When khellin is combined with UVA (KUVA), it is reported to repigment vitiligo skin as effectively as PUVA photochemotherapy, but without the adverse effects reported with PUVA. The exact mechanism for khellin-induced repigmentation is still to be determ

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31

Jacobs, Brittany-Amber. "Cancer cell behaviour following parasite exposure." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29273.

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Infectious diseases, including helminthiases, are estimated to cause 16.1% of global cancer cases. While certain helminths are conclusive causes of cancer, others have been shown to reduce the disease. It is currently unknown why differing helminth infections promote or prevent cancer development and progression, or which cellular mechanisms are altered following exposure. Using several in vitro and in vivo techniques, this study aimed to determine the effect that certain helminths have on the progression of cervical and colorectal cancer. The results revealed that antigen from the hookworm Ni

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Chia, Julius Ebua. "The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32563.

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T regulatory cells are critical in the maintenance of self-tolerance, immune homeostasis and regulation of the immune system. Cytokine signalling is a dominant component of environmental signals which controls the function of Forkhead box P3 (Foxp3) regulatory T cells. This thesis addressed the hypothesis that interleukin-4 receptor alpha (IL-4Rα) signalling on T regulatory cells (T reg) play a role in the stability of T reg cells. Loss of IL-4Rα signalling on T reg cells may shift the immune balance from a Foxp3+ T reg to a Th1 effector function essential for Th1 disease outcome. Regulatory c

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Baker, Zoe. "The role of Surfacant Protein D in the control of human helminth infections." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32585.

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Lung produced surfactant protein D (SP-D) is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes to protection against murine parasitic nematode infections, to human work. In the first part of this study, we determined whether individuals exposed to helminths have altered serum SP-D in comparison to unexposed individuals, through analysis (ELISA and Western Blot) of bio banked samples in 2 clinical cohorts from South Africa. Secondly, we aimed to ident

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Kieswetter, Nathan Scott. "Remodelling of Mycobacterial Peptidoglycan During Cell Division and the Epigenetics of Macrophages during M. tuberculosis infection." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33815.

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There are so many people who I would like to thank. If it takes a village to raise a child, it certainly takes a city to train a scientist. Firstly, I would like to thank my supervisors, A/Prof Reto Guler, Prof Frank Brombacher and Dr Mumin Ozturk for allowing me to further my studies and allowing me to work on several interesting projects. Specifically, I would like to take this opportunity to thank A/Prof Reto Guler for his insightful patient advice, training and ever willingness to talk about my work. His brilliant example has made me a better scientist. Further, I would also like to thank

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Clauson, John. "Cryptococcus neoformans Serotype Groups Found in Clinical and Environmental Isolates." TopSCHOLAR®, 1993. http://digitalcommons.wku.edu/theses/1888.

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Cryptococcus neoformans is an encapsulated yeast responsible for severe meningoencephalitis. The importance of epidemiological studies on cryptococcosis has increased since the beginning of the AIDS epidemic. C. neoformans exists in two varieties containing four serotypes, C. neoformans var. neoformans (serotypes A and D) and C. neoformans var. gattii (serotypes B and C). Locally C. neoformans var. neoformans has been associated with pigeon feces during those months having an average temperature of 64.2°F j(17.8°C) and above. Clinical and environmental isolates of C. neoformans obtained from

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Montan, Per. "Immunological and inflammatory mechanisms in ocular allergy with special reference to vernal keratoconjunctivitis : clinical and experimental studies /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4170-X/.

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Yee, Daphne. "Clinical epidemiology of mono-pyrazinamide-resistant Mycobacterium tuberculosis in Quebec." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101809.

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Rationale. In Quebec, 6.2% of all Mycobacterium tuberculosis (TB) isolates from Canadian-born patients are resistant to pyrazinamide alone (mono-PZA-R). Over 90% of mono-PZA-R isolates in Quebec have been characterized by a specific and unique mutation in the pncA gene. The unusually high prevalence of mono-PZA-R disease and its associated mutational profile in Quebec provided an exceptional opportunity to study the epidemiologic and clinical significance of mono-PZA-resistance in patients with active TB. Methods. 67 patients with mono-PZA-R TB diagnosed between 1 Jan 1990 and 31 Dec 2000 were

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Rowland, Rosalind. "Evaluation of the safety and immunogenicity of candidate tuberculosis vaccines through Phase I Clinical Trials." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374738/.

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Fransson, Moa. "CNS-Targeted Cell Therapy for Multiple Sclerosis." Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132364.

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Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. MS has been considered to be driven by T helper type1 (Th1) lymphocytes but new data indicate the involvement of Th17 responses. T cells from patients with MS that were evaluated for immunological status secreted both interferon-γ and interleukin-17 upon stimulation. However, T cells from patients with MS in remission, in cont

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Gahleitner, Florian. "Viral induced exacerbations of childhood asthma : clinical findings, virology and cytokine responses." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/383589/.

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Chavada, Govind. "Clinical heterogeneity, diagnostic features, outcomes of Guillain-Barré syndrome spectrum disorders : an analysis of IGOS UK data." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8497/.

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Introduction: GBS has a highly diverse clinical course and outcome. Currently available literature suggests that despite treatment about 20 % of patients remain disabled at one year and about 5 % patients die. These data come from clinical trials conducted between 1984 and 2006. Most of these studies included severe GBS cases. We conducted a multicentre prospective observational study looking at clinical and biological determinants of prognosis of GBS. As part of this study, I had an opportunity to analyse the data collected from 15 UK centres; looking at clinical and treatment patterns, vario

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Kronqvist, Marianne. "Clinical and immunological studies of respiratory allergy among farmers : with focus on dust mite allergy /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4411-3/.

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Brombacher, Tiroyaone M. H. "The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/12245.

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Includes abstract.<br>Includes bibliographical references (leaves 101-111).<br>Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N. brasiliensis) and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis and S. mansoni infection.

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Kirstein, Frank. "Investigations of immune responses in different mouse models of allergic asthma." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3171.

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Basich, Dinko. "The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/13437.

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Includes bibliographical references (leaves 108-126).<br>Infection by the parasitic nematode Nippostrongylus brasiliensis involves migration through the lungs, causing significant damage and generating chronic lung pathology. The resolution of N. brasiliensis infection and also the induction of pulmonary pathology, including goblet cell hyperplasia and acute airway inflammation, depend on IL-4Rá signalling. A key feature of IL-4Rá signalling is the induction of a strong TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are associated with tissue rem

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Danielsson, Olof. "The Clinical and Pathological Spectrum of Idiopathic Inflammatory Myopathies : Implications for pathogenesis, classification and diagnosis." Doctoral thesis, Linköpings universitet, Avdelningen för neuro- och inflammationsvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132768.

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Background: Idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of diseases with severe consequences for the life of affected patients. Dermatomyositis, polymyositis and inclusion body myositis (IBM) are the classical representatives of this group. The treatments given today often have limited effects, and are taken at the cost of side effects. Major obstacles in the search for more effective treatments are; (1) an incomplete understanding of the disease mechanisms, (2) difficulties to delineate homogeneous disease groups for clinical studies and (3) the sometimes challen

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Wilson, Nicole K. "Borderline Lesions Exhibit Clinical and Graft Survival Characteristics Common to Acute Cellular Rejection." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627665576477761.

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Lee, Eric Cheuk Kin. "Characterising the clinical phenotype and immunopathophysiology of food protein-induced enterocolitis syndrome in Australian children." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24080.

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FPIES is an uncommon food allergic disorder in infants and children. It differs clinically from IgE-mediated food allergy presenting acutely with delayed profuse vomiting, at times with lethargy, pallor, floppiness and diarrhoea. The diagnosis is difficult as it is based on clinical criteria, with no diagnostic test aside from oral food challenge. There is geographic variation in demographic features and the immunopathophysiology of FPIES is largely unknown. In this thesis, a retrospective study was undertaken to characterise the demographic and clinical phenotype of FPIES in Australian childr

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Wragg, Joseph. "Transcriptomic analysis of the tumour vasculature and its clinical relevance." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6544/.

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The vasculature of many solid tumours is highly distinct from that of its host tissue, both structurally and in terms of functional protein expression. These differences offer an opportunity for specific targeting of therapeutics against the tumour vasculature. This thesis describes the investigation of this tumour vascular profile, in clinical samples from renal cell carcinoma, colorectal cancer and colorectal liver metastases, as well as murine breast tumours resistant to the antiangiogenic drug, sunitinib. This analysis allowed the identification of three tumour endothelial markers in renal

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Eliasson, Henrik. "Tularemia : epidemiological, clinical and diagnostic aspects." Doctoral thesis, Örebro University, Academy of Health Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1806.

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<p>Tularemia is a zoonosis caused by the small, fastidious, gram-negative rod Francisella tularensis that appears over almost the entire Northern Hemisphere. In Sweden, tularemia has appeared mainly in restricted areas in northern parts of central Sweden.</p><p> The disease can be transmitted through several routes: direct contact with infected animals, by vectors, through contaminated food or water or through inhalation of aerosolized bacteria. Distinct clinical forms of the disease are seen, depending on the route of transmission. During the last years, tularemia has emerged in new areas in

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