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Journal articles on the topic 'Clinical pharmacist plays a major role in detecting'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kusuma, Kumari.S* Rajesh .G Dr. Siddarama. R. "DRUG INDUCED DYSELECTROLYTEMIA –A CASE REPORT." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2047–50. https://doi.org/10.5281/zenodo.834968.

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Abstract: Spiranolactone and Eplerenone were belongs to the class of potassium sparing diuretics where as Torsemide belongs to the loop diuretic class, they mainly acts by blocking the function of aldosterone hormone to retain the sodium and excrete potassium. By irrational use of these drugs induced dyselectrolytemia like hyperkalemia and hyponatremia. A 55 years female patient was admitted in cardiology department with the chief complaints of drowsiness and slow response to commands by using of the diuretics (Spiranolactone , Eplerenone and Torsemide) causes the electrolytes induced hyperkal

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Clark, Mickayla, Thomas Clark, Afeefa Bhatti, and Timothy Aungst. "The Rise of Digital Health and Potential Implications for Pharmacy Practice." Journal of Contemporary Pharmacy Practice 64, no. 1 (2017): 32–40. http://dx.doi.org/10.37901/jcphp16-00012.

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The rise of technology in healthcare has led to dramatic changes in approaches to patient care by healthcare professionals. The realm of digital health has created new opportunities for pharmacists to engage patients in clinical practice. Pharmacies and industry are increasingly integrating these innovations into their businesses and practice. This article highlights areas of digital health for pharmacists to be aware of, in particular regarding areas of medication adherence and disease management. Technology plays a massive role in our individual lives; it has morphed the human experience in

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Kumawat, Shivani, V. M. Bhagat, Bhavna Gamit, and B. M. Jha. "Cytological detection of microfilaria in unsuspected clinical scenario." International Journal of Research in Medical Sciences 6, no. 3 (2018): 1051. http://dx.doi.org/10.18203/2320-6012.ijrms20180639.

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Filariasis is a major public health problem in tropical countries, including India. Fine needle aspiration cytology plays an important role in prompt recognition of disease. Aim was to highlight the role of fine needle aspiration cytology as a simple and cost effective tool to detect microfilarial infestation. A retrospective study of 10 cases in which fine needle aspiration cytology was done and was useful in detecting microfilaria. Patient’s age were ranging from 19-62 years. M:F ratio being 7:3. Out of ten cases, maximum cases of microfilarial detection was reported in soft tissue swelling

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Dasta, Joseph F., and David F. Driscoll. "Drug-Induced Metabolic Disorders and Parenteral Nutrition in the Intensive Care Unit: A Pharmaceutical and Metabolic Perspective." DICP 23, no. 5 (1989): 363–71. http://dx.doi.org/10.1177/106002808902300502.

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Since its inception, the field of parenteral nutrition has continued to evolve requiring the expertise of several health care disciplines. This feature has made nutrition support unique among clinical subspecialties. As a member of this team, the pharmacist plays a critical role in the provision of sterile admixtures, compatible nutritional formulations, and cost-effective, therapeutically equivalent strategies. The pharmacist has become more involved in the clinical care of the patient, with particular emphasis on the development of drug-induced metabolic disorders. The multitude of drugs pre

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Ann, Vazhayil Kuruvilla, Ramesh M, and P. Madhu C. "Improving Antibiotic Use in Surgical Care: Impact of Clinical Pharmacist Interventions on Optimizing Patient Therapy." Indian Journal of Science and Technology 15, no. 33 (2022): 1634–41. https://doi.org/10.17485/IJST/v15i33.100.

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Abstract <strong>Objectives:</strong> To assess the nature of drug-related problems (DRPs) associated with antibiotic use and to evaluate the level of significance of clinical pharmacist interventions in surgical care. <strong>Methods:</strong> This prospective interventional study was carried out for 1 year in the wards of General Surgery. The in-patients were followed daily and reviewed for DRPs. The identified DRPs were categorized according to the Hepler and Strand classification. Drug-related problems other than those in Hepler and Strand classification were categorized sep

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Ruić, Marija, and Tatjana Matijaš. "CT Colonography – Overview of Current Clinical Practice." Radiološki vjesnik 46, no. 2 (2022): 18–24. http://dx.doi.org/10.55378/rv.46.2.3.

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CTC is a diagnostic method that has been developed for more than a decade and there is a large number of studies conducted to describe its capabilities. By using new generations of CT devices and advanced software, colon analysis is possible in a relatively short time. On the other hand, high sensitivity for detecting polyps and the possibility of detecting bowel abnormalities make CTC an interesting and desirable method. The aim of this article is to determine the advantages and disadvantages of CTC, as well as its role in colon cancer screening. Compared to colonoscopy, CTC is a less invasiv

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Abdalkader, Mohamad, Juliana Xie, Anna Cervantes-Arslanian, Courtney Takahashi, and Asim Z. Mian. "Imaging of Intracranial Infections." Seminars in Neurology 39, no. 03 (2019): 322–33. http://dx.doi.org/10.1055/s-0039-1693161.

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Central nervous system (CNS) infections are a major source of morbidity and mortality despite the remarkable progress in prevention and treatment of infectious disease. Because of the difficulty of direct tissue sampling, imaging plays a crucial role in detecting, diagnosing, and monitoring the therapeutic response of CNS infections. An accurate diagnosis in CNS infections is especially rewarding, given the availability of potential effective antimicrobials.Bacterial, viral, fungal, and parasitic infections may affect the brain and/or its meningeal coverings, and can be characterized by a vari

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Ito, Takahide, and Michihiro Suwa. "Left atrial spontaneous echo contrast: relationship with clinical and echocardiographic parameters." Echo Research and Practice 6, no. 2 (2019): R65—R73. http://dx.doi.org/10.1530/erp-18-0083.

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Spontaneous echo contrast (SEC) indicates blood stasis in cardiac chambers and major vessels, and is a known precursor of thrombus formation. Transesophageal echocardiography plays a pivotal role in detecting and grading SEC in the left atrial (LA) cavity. Assessing LA SEC can identify patients at increased risk for thromboembolic events. LA SEC also develops in patients who have sinus rhythm, especially in those with heart failure. Detection of LA SEC is not uncommon in subjects who have multiple cardiovascular comorbidities, although mechanisms behind this association are not fully understoo

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Mavarani, Laven, Philipp Hillger, Thomas Bücher, et al. "NearSense – Advances Towards a Silicon-Based Terahertz Near-Field Imaging Sensor for Ex Vivo Breast Tumour Identification." Frequenz 72, no. 3-4 (2018): 93–99. http://dx.doi.org/10.1515/freq-2018-0016.

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AbstractBreast Cancer is one of the most frequently diagnosed cancer diseases worldwide, and the most common invasive tumour for women. As with all cancers, early detection plays a major role in reducing the mortality and morbidity rate. Currently, most breast cancers are detected due to clinical symptoms, or by screening mammography. The limitations of these techniques have resulted in research of alternative methods for imaging and detecting breast cancer. Apart from this, it is essential to define precise tumour margins during breast-conserving surgeries to reduce the re-excision rate. This

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Sripada, Ramam, Suresh Kumar Sv, Devanna N, and Kandula Ravindra Reddy. "PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS AMONG THE GERIATRIC PATIENTS AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 121. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27775.

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Objective: The objective of this study was to study the prevalence and severity of possible drug-drug interactions (DDIs) among the geriatric patients.Methods: The present study was a retrospective cross-sectional study. Case records of geriatric inpatients from the medical records department were included in the study and the case records of all the remaining age group inpatients were excluded from the study. All the collected cases were subjected to check for the DDIs using the software Micromedex 2.0 and were categorized into minor, moderate, and major based on the severity.Results: In this

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Joseph, Aaron, Christil Rajan, Daiamon Kharlynnai, and Varada P. V. "A study on pharmacist intervention in anti-epileptic drugs at a tertiary care hospital." International Journal of Research in Medical Sciences 12, no. 8 (2024): 2892–98. http://dx.doi.org/10.18203/2320-6012.ijrms20242217.

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Background: Antiepileptic drugs (AEDs) have been used for the treatment of epilepsy and other neurological disorders since 19th century. Several classes of AEDs are available for epilepsy, many of them are also used for migraines, bipolar disorder, schizophrenia, depression, and neuropathy. Methods: Total 212 patients participated in an Ambi-directional observational cohort study conducted at Mallige medical center, Bangalore. Reviewed and evaluated both inpatients and outpatients case sheets and the data were entered into Microsoft excel. The data was analysed using version 27 of SPSS and sta

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Gruber, Helen E., and Edward N. Hanley. "Do We Need Biomarkers for Disc Degeneration?" Biomarker Insights 1 (January 2006): 117727190600100. http://dx.doi.org/10.1177/117727190600100004.

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Disc degeneration plays a major role in this country's medical, social and economic structure. The life-time prevalence of low back pain, which has disc degeneration as its cause, is about 80% in the general population. It is a primary cause of disability and estimated costs related to low back disorders exceed $100 billion per year in the U.S. alone. Biomarkers are becoming increasingly important as indicators of the presence of disease, and in evaluating outcomes during clinical treatment. Cell-based biologic therapies which are currently being developed to treat disc degeneration are going

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F.P, Mohsina, Faheem I.P, and Aquil-ur-Rahim Siddiuque. "A Study on Pharmacist Mediated Intervention in Identifying and Reporting of Adverse Drug Reactions at a Tertiary Care Hospital." Galore International Journal of Health Sciences and Research 6, no. 4 (2021): 26–41. http://dx.doi.org/10.52403/gijhsr.20211006.

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Background: Adverse drug reactions are major problem in health care system due to its consequences - morbidity, mortality and health care cost. Recent epidemiologic research reveals that the total incidence rate of ADRs was 6.7%, with an overall fatality rate of 0.32%. Method: A prospective observational study was carried out for 6 months in a tertiary care hospital. Patients admitted to the department of medicine, Pediatrics, orthopedics & surgery were selected randomly and followed from date of admission to date of discharge by enrolling into the study by considering the study criteria.

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Kosztulska, Bernadetta, Zbigniew Bartuzi, and Natalia Ukleja-Sokołowska. "Current State of Celery Allergy: Is Discovering Api g 7 a Milestone in Diagnosing Celeriac-Allergic Patients?" International Journal of Molecular Sciences 26, no. 12 (2025): 5840. https://doi.org/10.3390/ijms26125840.

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Celery allergy is a common food allergy, particularly among the European population. Currently, several diagnostic methods are available, including multiplex assays, which are useful for identifying celery-allergic patients. However, all of these methods have certain limitations. Api g 7 is a newly identified celeriac allergen belonging to the defensin protein family. Its clinical relevance lies in the high risk of severe systemic reactions among patients sensitized to this molecule. Patients sensitized to Api g 7 are often co-sensitized to Art v 1, the major mugwort (Artemisia vulgaris) aller

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MARIAN, Mariana, Dumitru-Octavian SOREANU, and Mihai MAREȘ. "COMPARATIVE PARAMETER ANALYSIS OF CLSI AND EUCAST BROTH MICRODILUTION FOR YEASTS AND FILAMENTOUS FUNGI." Scientific Papers Journal VETERINARY SERIES 67, no. 4 (2024): 151–54. https://doi.org/10.61900/spjvs.2024.04.23.

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Invasive fungal infections caused by opportunistic fungi such as Candida spp., Aspergillus spp., and Cryptococcus spp. continue to be major causes of morbidity and mortality in spite of advancements in diagnostic tools and antifungal treatments. Despite the tendency to broaden the therapeutic options in invasive fungal infections, the misuse of these antifungals has led to the emergence of antifungal resistance. In this context, antifungal susceptibility testing (AFST) plays a vital role in guiding treatment decisions, predicting clinical outcomes, detecting resistance, and mapping epidemiolog

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Anaswara, A.* Ancy T. S. Akhila S. P. Nithin Manohar R. Anjana U. J. Prasobh G. R. "A Review on The Assessment of Knowledge, Attitude and Practices Regarding Adverse Drug Reactions (ADR) And Its Reporting of Community Pharmacist." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 252–59. https://doi.org/10.5281/zenodo.14802522.

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Adverse drug reactions (ADRs) are a major global health concern due to their impact on morbidity, mortality, hospitalizations, and healthcare costs. Factors such as advanced age, comorbidities, and polypharmacy increase the risk of ADRs. Despite rigorous preclinical and clinical safety evaluations, some ADRs are only detected post-market. Pharmacovigilance (PV) systems, such as the UAE's national ADR surveillance program, play a crucial role in detecting and reporting ADRs. However, barriers to effective ADR reporting still exist. This study assessed the knowledge, attitude, and practice (KAP)

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Carter, Sean W. D., Samantha Neubronner, Lin Lin Su, et al. "Chorioamnionitis: An Update on Diagnostic Evaluation." Biomedicines 11, no. 11 (2023): 2922. http://dx.doi.org/10.3390/biomedicines11112922.

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Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and va

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René, D. Magnini, H. Millogo-Koné, A. Hilou, S. Compaore, J.-M. Pagès, and A. Davin-Regli. "A Review on ethnobotanical uses, biological activities and phytochemical aspects of Acacia senegal (L.) Willd. and Acacia seyal Delile. (Fabaceae)." International Journal of Plant Science and Horticulture 2, no. 1 (2020): 32–55. https://doi.org/10.36811/ijpsh.2020.110023.

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The genus Acacia is a group of tropical plants species used in folk medicine due to virtue of its many therapeutic properties. In this document, we review the Ethnopharmacology, biological and phytochemical activities of the two major plant species used. Although, several researchers has been done, <em>Acacia senegal</em> (L.) Willd. and <em>Acacia seyal</em> Delile. are among the species of the genus for which phytochemical study is limited, few bioactive compounds and properties described. Based on these current traditional uses, it is necessary to carry out more biochemi

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Zamagni, Elena, Michele Cavo, Bita Fakhri, Ravi Vij, and David Roodman. "Bones in Multiple Myeloma: Imaging and Therapy." American Society of Clinical Oncology Educational Book, no. 38 (May 2018): 638–46. http://dx.doi.org/10.1200/edbk_205583.

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Bone disease is the most frequent disease-defining clinical feature of multiple myeloma (MM), with 90% of patients developing bone lesions over the course of their disease. For this reason, imaging plays a major role in the management of disease in patients with MM. Although conventional radiography has traditionally been the standard of care, its low sensitivity in detecting osteolytic lesions has called for more advanced imaging modalities. In this review, we discuss the advantages, indications, and applications of whole-body low-dose CT (WBLDCT), 18F-fluorodeoxyglucose (FDG)-PET/CT, MRI, an

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Al-Taani, Ghaith M., Suhaib M. Muflih, Sayer I. Al-Azzam, and Karem H. Alzoubi. "Costs saved and avoided from pharmacist interventions to address drug-related problems identified from outpatient clinics in Jordan." PLOS ONE 19, no. 6 (2024): e0302287. http://dx.doi.org/10.1371/journal.pone.0302287.

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Background The pharmacist plays an essential role in identifying and managing drug-related problems. The aim of this research was to assess the costs avoided by clinical pharmacist interventions to resolve drug-related problems. Research design and methods Clinical pharmacists identified drug-related problems and interventions to address them in consecutive outpatients visiting internal medicine clinics at major teaching and public hospitals in Jordan from September 2012 to December 2013. The costs avoided by each intervention to address drug-related problems were collected from the literature

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Battista, Petronilla, Christian Salvatore, and Isabella Castiglioni. "Optimizing Neuropsychological Assessments for Cognitive, Behavioral, and Functional Impairment Classification: A Machine Learning Study." Behavioural Neurology 2017 (2017): 1–19. http://dx.doi.org/10.1155/2017/1850909.

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Subjects with Alzheimer’s disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, despite the existence of clinical measures that are used to classify and diagnose AD, a large amount of subjectivity continues to exist. Our aim was to assess the potential of machine learning in quantifying this process and optimizing or even reducing the amount of neuropsychological

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Dzyuba, Sergei V. "BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes". Biosensors 10, № 12 (2020): 192. http://dx.doi.org/10.3390/bios10120192.

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Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are am

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Rahman, Aminur. "Positron-emission tomography (PET) and single-photon-emission computed tomography (SPECT) Diagnosis of Neurological disorders." Bangladesh Journal of Medicine 36, no. 1 (2024): 3–14. https://doi.org/10.3329/bjm.v36i1.78589.

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Functional neuroimaging is a major tool in the study of neurological illnesses. It plays a role in diagnosis, therapy, and surgical planning. It can aid in the identification and understanding of functional movement impairments, as well as their differentiation from other diseases. It can also aid in detecting co-morbid organic illnesses. Positron-emission tomography (PET) and single-photon-emission computed tomography (SPECT) are well-known nuclear-medicine imaging techniques utilized in current neurological diagnostics. PET (Positron Emission Tomography) and SPECT (Single Photon Emission Com

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Khan, Abdul Hannan, Sagheer Abbas, Muhammad Adnan Khan, et al. "Intelligent Model for Brain Tumor Identification Using Deep Learning." Applied Computational Intelligence and Soft Computing 2022 (January 21, 2022): 1–10. http://dx.doi.org/10.1155/2022/8104054.

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Brain tumors can be a major cause of psychiatric complications such as depression and panic attacks. Quick and timely recognition of a brain tumor is more effective in tumor healing. The processing of medical images plays a crucial role in assisting humans in identifying different diseases. The classification of brain tumors is a significant part that depends on the expertise and knowledge of the physician. An intelligent system for detecting and classifying brain tumors is essential to help physicians. The novel feature of the study is the division of brain tumors into glioma, meningioma, and

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Kumar, Anoop, and Henna Khan. "Signal Detection and their Assessment in Pharmacovigilance." Open Pharmaceutical Sciences Journal 2, no. 1 (2015): 66–73. http://dx.doi.org/10.2174/1874844901502010066.

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Signal detection and its assessment is the most important aspect in pharmacovigilance which plays a key role in ensuring that patients receive safe drugs. For detection of adverse drug reactions, clinical trials usually provide limited information as they are conducted under strictly controlled conditions. Some of the adverse drug reactions can be detected only after long term use in larger population and in specific patient groups due to specific concomitant medications or disease. The detection of unknown and unexpected safety signals as early as possible from post marketing data is one of t

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Gendarme, Sébastien, Olivier Bylicki, Christos Chouaid, and Florian Guisier. "ROS-1 Fusions in Non-Small-Cell Lung Cancer: Evidence to Date." Current Oncology 29, no. 2 (2022): 641–58. http://dx.doi.org/10.3390/curroncol29020057.

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The ROS-1 gene plays a major role in the oncogenesis of numerous tumors. ROS-1 rearrangement is found in 0.9–2.6% of non-small-cell lung cancers (NSCLCs), mostly lung adenocarcinomas, with a significantly higher rate of women, non-smokers, and a tendency to a younger age. It has been demonstrated that ROS-1 is a true oncogenic driver, and tyrosine kinase inhibitors (TKIs) targeting ROS-1 can block tumor growth and provide clinical benefit for the patient. Since 2016, crizotinib has been the first-line reference therapy, with two-thirds of the patients’ tumors responding and progression-free su

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Tuğba Sert and Şule Arslan. "Clinical nutrition approach to colon cancer." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 1397–404. http://dx.doi.org/10.30574/wjarr.2024.23.3.2503.

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Colon cancer is a type of cancer that affects the large intestine or rectum, with risk increasing with age. It typically shows no symptoms in its early stages and is often diagnosed in advanced stages, where treatment options are limited. In 2020, there were approximately 1.9 million new colorectal cancer cases and over 930,000 deaths worldwide. Colorectal cancer is the third most common cancer globally and the second leading cause of cancer-related deaths. Colon polyps are precancerous lesions identified through colonoscopy. The size, surface structure, and number of polyps are associated wit

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Tuğba, Sert, and Arslan Şule. "Clinical nutrition approach to colon cancer." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 1397–404. https://doi.org/10.5281/zenodo.14945368.

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Colon cancer is a type of cancer that affects the large intestine or rectum, with risk increasing with age. It typically shows no symptoms in its early stages and is often diagnosed in advanced stages, where treatment options are limited. In 2020, there were approximately 1.9 million new colorectal cancer cases and over 930,000 deaths worldwide. Colorectal cancer is the third most common cancer globally and the second leading cause of cancer-related deaths. Colon polyps are precancerous lesions identified through colonoscopy. The size, surface structure, and number of polyps are associated wit

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Al Shamsi, Hilal Salim, Talib Salim Al Kalbani, Abdullah Ghthaith Almutairi, and Sulaiman Salim Al Mashrafi. "Factors Influencing Prescribing Decisions Among Primary Health Care Physicians in Al-Buraimi Governorate, Oman." Global Journal of Health Science 11, no. 4 (2019): 12. http://dx.doi.org/10.5539/gjhs.v11n4p12.

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Prescribing plays a major role in the activities practiced by physicians. The vast majority of health care consultations occur in the primary health care (PHC) system, where medication errors are more likely and can even be potentially life threatening. The goal of this study is to explore the factors affecting prescribing decisions among physicians working in PHC institutions in Al-Buraimi Governorate, Oman using a cross-sectional survey. Of the 53 physicians who received the questionnaire, 41 (77.4%) completed it. The Cronbach&#39;s alpha of the instrument was 0.913. The main patient fac

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Fiegler-Rudol, Jakub, Artur Los, Barbara Lipka, and Monika Tysiąc-Miśta. "The use of artificial intelligence in caries detection - literature review." Wiadomości Lekarskie, no. 5 (May 30, 2005): 1194–98. https://doi.org/10.36740/wlek/202055.

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Artificial intelligence plays an increasingly important role in modern dentistry, offering the possibility of precise and quick diagnostic image analysis and supporting the process of pathology detection. Aim: The study aims to discuss the use of artificial intelligence in caries detection, with an emphasis on radiographs and intraoral imaging analysis, and to assess the potential of this technology in the quality and efficiency of dental diagnostics improvement. Methods: A review of the scientific literature covering the years 2015–2024 was carried out, analyzing the results of studies on the

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Mangalore, Sandhya, Pramod Pal, Shaik Pasha, Saini Jithender, and Yadav Ravi. "A Comparative Analysis of Different MRI Sequences Dedicated for Invivo Detection of Mineralization in a Single Large Cohort of Progressive Supranuclear Palsy and Healthy Controls." Neurology India 73, no. 4 (2025): 752–57. https://doi.org/10.4103/neuroindia.ni_850_17.

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Iron plays an important role in normal brain metabolism. Increase in brain iron is a part of the normal brain development, but an excessive deposition of brain iron may be a risk factor for degenerative diseases. At the clinical setting, there are two major issues of controversy. One is that of interpreting the varying degree of mineralization, which occurs with normal aging, which is physiological from pathological mineralization. The second issue is interpretating and drawing a single conclusion, as to whether mineralization is occurring or not from the various MRI sequences available. Vario

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Sunny, Angel, J. K. Alan, Megha S. Arali, Sara Babu, Syed Khaleel Ahmed, and Vinod Naik. "A Prospective Observational Study on Incidence, Implications and Management of Seizures Following Stroke." Journal of Pharmaceutical Research International 36, no. 12 (2024): 20–31. http://dx.doi.org/10.9734/jpri/2024/v36i127626.

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Background: Seizures following a stroke often indicate a more severe incident, typically resulting in extended hospital stays and a heightened risk of long-term disability. Management strategies generally include the use of anti-epileptic drugs to mitigate the frequency and severity of seizures. Objectives: this study aims to evaluate the incidence and risk factors assosciated for seizures after stroke, differentiating between acute symptomatic seizures and late seizures. Additionally, it assess dependency levels of patients after stroke and management of seizures after stroke. Methodology: We

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Tantiworawit, Adisak, Suebsakul Tapanya, Arintaya Phrommitikul, et al. "Cardiovascular Complications Of Thalassemia Patients In The Iron Chelation Therapy Era." Blood 122, no. 21 (2013): 5602. http://dx.doi.org/10.1182/blood.v122.21.5602.5602.

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Abstract Background Cardiac complications are the most common cause of death in thalassemia, accounting for up to 71% in the past. Iron chelation therapy is given to patients with iron overload to prevent these complications. The cost effectiveness of iron chelation therapy was arguable. This study aims to evaluate the prevalence of cardiac complication and the correlation between risk factors in iron chelation therapy era. Method This is a cross sectional study from June 2011- May 2012. All thalassemia aged > 15 years old were enrolled. Clinical data and hemoglobin typing were reviewed. Ec

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Dychiching, Arlene Melissa T., and Henry L. Chan. "Eosinophil-to-Leukocyte Ratio as an Inflammatory Marker in Patients With Coronary Artery Disease—A Retrospective Cohort Study." Philippine Journal of Cardiology 51, no. 2 (2023): 72–79. http://dx.doi.org/10.69944/pjc.9d2aeda181.

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BACKGROUND: Cardiovascular disease remains one of the leading causes of death and major causes of disability and loss of productivity in adults worldwide. Inflammation is a key feature of atherosclerosis and its clinical manifestations. Because inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important to help diagnostic accuracy and provide prognostic information about coronary artery disease (CAD). The eosinophil count and eosinophil-to-leukocyte ratio (ELR), in particular, have become novel biomarkers for risk assessmen

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Afrin, Rawnak, Fatema Sultana Haque, Shankar Kumar Biswas, Sanowar Hossain, and Mahmood Uz Jahan. "Role of Whole-Body Tc 99m MDP Bone Scintigraphy for Evaluating Skeletal Metastasis in Patients with Lung Cancer." Bangladesh Medical Research Council Bulletin 42, no. 3 (2017): 132–36. http://dx.doi.org/10.3329/bmrcb.v42i3.32214.

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Lung cancer is the third most common site of origin of metastatic cancer deposits in bone, after breast and prostate. Its metastasis to bone is one of the most aggressive tumors and has a very unfavorable prognosis. This retrospective descriptive study was designed to detect the skeletal metastasis of carcinoma (Ca) lung patient by Tc 99m MDP bone scan. The medical records of all patients attended between January 2015 and July 2015 with a diagnosis of lung cancer were reviewed. Lung cancer in all patients was confirmed pathologically, and patients underwent whole-body bone scan for evaluating

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Hadebe, Bawinile, Lerwine Harry, Lerato Gabela, et al. "Comparing 68Ga-Pentixafor,18F-FDG PET/CT and Chemokine Receptor 4 Immunohistochemistry Staining in Breast Cancer: A Prospective Cross Sectional Study." Cancers 17, no. 5 (2025): 763. https://doi.org/10.3390/cancers17050763.

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Background. CXCR4 is a chemokine receptor that is frequently overexpressed in invasive breast cancer and plays a major role in tumor proliferation, aggressiveness and metastasis. The aim of this prospective study was to establish the value of CXCR4-directed PET imaging in patients with breast cancer using the novel CXCR4-targeted PET probe 68Ga-Pentixafor by comparing it with 18F-FDG PET/CT (n = 40). Materials and methods. In this prospective cross-sectional study, fifty-one patients with breast cancer aged 36–81 (median (Q1-Q3) 51 (42.5–63)), n = 47 (92%) with initially diagnosed and n = 4 (8

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Donaliazarti. "Peran Laktat Pada Sepsis Dan Pemeriksaan Laboratoriumnya." Scientific Journal 1, no. 4 (2022): 269–77. http://dx.doi.org/10.56260/sciena.v1i4.53.

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Abstract Sepsis is a clinical syndrome due to infection and manifests as systemic inflammatory response syndrome (SIRS). Sepsis is a major cause of morbidity and mortality in hospitalized patients. In septic conditions, large amounts of lactate can be produced because of increased aerobic or anaerobic lactate production combined with decreased lactate clearance. Measurement of lactate levels is useful for detecting the presence of tissue hypoxia that is still not clearly visible so that therapy can be given earlier and clinician can monitor response to therapy. Increased lactate levels a

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Al-Naji, Ali, Ali J. Al-Askery, Sadik Kamel Gharghan, and Javaan Chahl. "A System for Monitoring Breathing Activity Using an Ultrasonic Radar Detection with Low Power Consumption." Journal of Sensor and Actuator Networks 8, no. 2 (2019): 32. http://dx.doi.org/10.3390/jsan8020032.

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Continuous monitoring of breathing activity plays a major role in detecting and classifying a breathing abnormality. This work aims to facilitate detection of abnormal breathing syndromes, including tachypnea, bradypnea, central apnea, and irregular breathing by tracking of thorax movement resulting from respiratory rhythms based on ultrasonic radar detection. This paper proposes a non-contact, non-invasive, low cost, low power consumption, portable, and precise system for simultaneous monitoring of normal and abnormal breathing activity in real-time using an ultrasonic PING sensor and microco

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Birry, Rania Ahmed Kadry Abdel Gawad. "Early Recognition of Alzheimer’s Disease using Brain MRI." International Journal of Health and Medicine 2, no. 1 (2017): 6. http://dx.doi.org/10.24178/ijhm.2017.2.1.06.

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Abstract—Alzheimer’s disease (AD) is a brain disease that causes a slow decline in memory, thinking and reasoning skills. It represents a major public health problem. Magnetic Resonance Imaging (MRI) have shown that the brains of people with (AD) shrink significantly as the disease progresses. This shrinkage appears in specific brain regions such as the hippocampus which is a small, curved formation in the brain that plays an important role in the limbic system also involved in the formation of new memories and is also associated with learning and emotions. Medical information on brain MRI is

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Beatrice. W, Moore-Igwe, Chukwuigwe-Igbere Orokwu, and Ken-Ezihuo Stella U. "Association of Erythrocytes Sedimentation Rate and Platelets Indices in Diabetes in the Elderly." International Journal of Medical Science and Health Research 07, no. 05 (2023): 66–73. http://dx.doi.org/10.51505/ijmshr.2023.7507.

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Recent research indicates that inflammation can contribute to the etiology of diabetes which is characterized by hyperglycemia and abnormalities in insulin secretion and/or activity. Erythrocyte sedimentation rate (ESR) is the most often utilized laboratory test for detecting systemic inflammation among all plasma inflammatory indicators. Patients with diabetes have reportedly shown altered platelets, due to "prothrombotic condition" with increased platelet reactivity leading to vascular problems. The objective of the study was to relate platelet indices and erythrocyte sedimentation rates wit

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Kamlekar, Sandeep, Arvind Yadav, Sakshi Singh, Meenu Pichholiya, Archana Rathore, and Sangita Gupta. "A cross-sectional study on knowledge, attitude, and practice of health-care professionals about adverse drug reactions reporting in a tertiary care teaching hospital of southern Rajasthan." National Journal of Physiology, Pharmacy and Pharmacology 14, no. 7 (2024): 1. http://dx.doi.org/10.5455/njppp.2024.14.12555202310012024.

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Background: Adverse drug reaction (ADR) reporting is the integrity of healthcare professionals (HCPs) to counteract fatal outcomes aroused by the use of medications during therapy. The underreporting of ADRs imposes major problems globally. The pharmacovigilance program plays a key role in detecting and preventing ADRs. Targeting the upcoming younger generation of HCPs and sensitizing them towards ADR reporting in their clinical practice is essential. Aims and Objectives: The main objective of our study is to measure the knowledge, attitude, and practice of interns and postgraduates at our ins

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Goerger, Krista A., Livia Stanger, Andrea Obi, and Michael Holinstat. "12-HETE, a Platelet Specific Oxylipin, As an Early Diagnostic Indicator for Thrombotic Risk." Blood 144, Supplement 1 (2024): 5413. https://doi.org/10.1182/blood-2024-212400.

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Thrombosis is one of the primary causes of morbidity and mortality in cardiovascular diseases. While thrombosis places a major burden on the healthcare system, there are no currently accepted biomarkers that can define the risk of arterial thrombosis or thromboembolism amongst patients with symptomatic vascular disease. Clinical D-dimer tests measure the breakdown products of a clot and are only used to diagnose if venous thrombosis has already occurred. Thromboelastography (TEG) and total-thrombus formation analysis system (T-TAS) are additional clinical tests that can be used to assess coagu

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Soverini, Simona, Cecilia Monaldi, Sara De Santis, et al. "Optimizing Molecular Diagnosis of Systemic Mastocytosis in the Era of KIT Tyrosine Kinase Inhibitors: Results of a Survey and of a Nationwide Proficiency Control Round of KIT D816V Mutation Testing Promoted By the RIMA (Rete Italiana MAstocitosi) Association." Blood 144, Supplement 1 (2024): 7640. https://doi.org/10.1182/blood-2024-202485.

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The recent introduction of targeted therapies for Systemic Mastocytosis (SM) has raised the awareness about the importance of timely and accurate diagnosis- that, outside reference centers, is hampered by the rarity of this malignancy, by the heterogeneity of clinical symptoms and presentation and by the need to integrate the specific expertise of different healthcare professionals. Molecular testing plays a key role in the diagnosis, classification and management of SM: detection of KIT D816V activating mutation, underlying approx 95% of SM cases, is among the diagnostic criteria and quantita

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Pericole, Fernando V., Fernanda Marconi Roversi, Adriana Silva Santos Duarte, et al. "BRD4 Short Isoform Is a Myelodysplasia Prognostic Marker Involved in Inappropriate DNA Damage Response." Blood 124, no. 21 (2014): 3234. http://dx.doi.org/10.1182/blood.v124.21.3234.3234.

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Abstract INTRODUCTION: Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. BRD4 is a BET member of bromodomain-containing proteins, known as epigenome readers, exerting key roles in chromatin remodeling and transcriptional regulation. BRD4 gene encodes two major isoforms, short (BRD4S) and long (BRD4L). Recently, Floyd SR et al (Nature, 2013) described BRD4S as an endogenous inhibitor of the DNA damage response (DDR). Under normal conditions, damaged DNA induces histone phosphorylation of H2AX at Ser 139 (γ-H2AX) and activates a protective

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Lugovskaya, Svetlana, Fyodor Dyukov, Elena Naumova, Margarita Pochtar, Olga Plehanova, and Vladimir Dolgov. "Screening for Paroxysmal Nocturnal Hemoglobinurea with Cytodiff Analysis." Blood 124, no. 21 (2014): 4962. http://dx.doi.org/10.1182/blood.v124.21.4962.4962.

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Abstract Introduction. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic stem cell disorder resulting from the somatic mutation of the X-linked phosphatidylinositolglycan complementation Class A (PIG-A) gene. PIGA mutations in PNH patients lead to a glycosylphosphatidylinositol (GPI)-linked membrane proteins expression deficiency.In PNH, there is a partial or absolute inability to make GPI-anchored proteins including complement-defense structures such as CD55 and CD59 on RBCs and WBCs. Clinical features of PNH include intravascular hemolysis, bone marrow failure, and thrombosis

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Wang, Hai, Chao Xie, Shiwu Li, et al. "Dysregulation, But Not Mutation Of p53 Signaling Pathway In Breast Implant-Associated Anaplastic Large Cell Lymphoma Cell Lines." Blood 122, no. 21 (2013): 4879. http://dx.doi.org/10.1182/blood.v122.21.4879.4879.

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Abstract A consistent feature of over 100 reported cases of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is their complex cytogenetic abnormalities, suggesting that genomic instability may drive lymphomagenesis and/or tumor progression. Loss of heterozygosity(LOH) of the TP53 tumor suppressor gene locus on the short arm of chromosome 17 (17p13.1) is a frequent finding. Human p53 plays an important role in cell cycle arrest, DNA repair, and apoptosis and it maintains genome stability by preventing mutations. Recently, three T cell breast lymphoma (TLBR) cell lines were de

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Kalpana, K. Gladys, K. Arun, Abraham Jebaraj, J. Senthil, M. Anandhi, and S. Felicia Roshini. "Study on Role of In-patient Pharmacist in Prescribed Drug Handling, Mixing, Infusing and Spillage Handling of Chemotherapeutic Drug-Cisplatin in a Tertiary Hospital Pharmacy." Journal of Pharmaceutical Research International, December 16, 2021, 525–35. http://dx.doi.org/10.9734/jpri/2021/v33i58b34233.

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The in-patient pharmacist in a cancer hospital plays a major role in patient care especially in patient taking chemotherapy and other narrow indexed drugs as a part of cancer treatment. The pharmacist works as one of the members of cancer treatment team along with physician, oncologist, nurse and other medical professionals. An oncology pharmacist has major role in chemotherapeutic drug handling, mixing, infusing and spillage handling in a disciplined manner. In order to get hands on training about ‘‘oncology-pharmacy’’, it is a mandatory novel pharmaceutical department where a hospital pharma

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Ali, Kashif, Osama Al-Quteimat, Rida Naseem, et al. "Incorporating a clinical oncology pharmacist into an ambulatory care pharmacy in pediatric hematology–oncology and transplant clinic: Assessment and significance." Journal of Oncology Pharmacy Practice, July 6, 2020, 107815522093416. http://dx.doi.org/10.1177/1078155220934167.

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Background Beta thalassemia patients, post-bone marrow transplant, and leukemia patients require long term therapy with an intense care follow-up especially for pediatric hematology–oncology origin. Emergence of side effects and noncompliance to therapy lead to reduced efficacy of medicines resulting in relapse of diseases. There is an increasing fact to support the incorporation of a pharmacist into clinical team due to their distinctive skills. Clinical oncology pharmacist with experience and specialized training in hematological cancers and bone marrow transplantation (BMT) patient care has

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Konduri, Gayathri, Harshini Kancherla, Keerthana Atla, Akhila Bollam, and Neelam Injeti. "Impact of Counseling and Intervention in Preventing the Drug-Related Problems after Hospitalization and Post-Discharge by Clinical Pharmacist." Journal of Pharmaceutical Research International, December 28, 2021, 32–38. http://dx.doi.org/10.9734/jpri/2021/v33i62a35146.

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Background and Objectives: A Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcome. Drug-related problems can occur at any stage of therapy which might be during prescribing, dispensing, administration. DRP’s account for most of the therapeutic failures. The prevention of DRP is the main responsibility of a pharmacist. According to Pharmaceutical care network Europe, system the DRP’S are classified according to problem, the underlying cause, intervention to be made, acceptance of intervention and outcome. The

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Vidhyalogini, T., Arvind Thangarasa, and Pavithra Panneer Selvam. "ROLE OF SERUM FERRITIN IN CHRONIC KIDNEY DISEASE: IMPLICATIONS AND CLINICAL SIGNIFICANCE." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, November 1, 2024, 67–69. https://doi.org/10.36106/ijsr/7110401.

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Millions of people worldwide suffer from chronic kidney disease (CKD), which frequently results in serious side effects such anaemia, cardiovascular illness, and higher mortality. Serum ferritin has become more popular among the biomarkers used to track the development of CKD and its related consequences. In the past, serum ferritin was thought to be an indirect indicator of the body's iron level and a kind of iron storage. Beyond iron metabolism, though, it plays a crucial role in chronic kidney disease (CKD) as a measure of oxidative stress and inflammation, two major pathogenic aspects of t

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