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Relevant bibliographies by topics / Clinical trials / Dissertations / Theses

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Dissertations / Theses on the topic 'Clinical trials'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kim, Anne(Anne Y. ). "Optimizing clinical trials with Open Trial Chain." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/121787.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 59-64).<br>The objective of this thesis is to study the challenges of data sharing in healthcare (namely clinical trials), and propose the use of Open Algorithms (OPAL) as a viable solution for research collaboration that allows for access to data without compromising data ownership (data is only used once for the intended purpose, raw data is never leaked, the value gener

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2

Vickers, Andrew J. "Homoeopathy and clinical trials." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302395.

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3

Zhang, Yifan. "Bayesian Adaptive Clinical Trials." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070079.

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Bayesian adaptive designs are emerging as popular approach to develop adaptive clinical trials. In this dissertation, I describe the mathematical steps for computing the theoretical optimal adaptive designs in biomarker-integrated trials and in trials with survival outcomes. Section 1 discusses the optimal design in personalized medicine. The optimal design maximizes the expected trial utility given any pre-specified utility function, though the discussion here focuses on maximizing responses within a given patient horizon. This work provides absolute benchmark for the evaluation of trial des

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4

Scarale, M. G. "RESPONSE - ADAPTIVE CLINICAL TRIALS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/344736.

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The question we posed at the beginning of this thesis was whether, in the presence of a clinical superiority of one of two possible treatments, it was possible to find an appropriate statistical methodology that would allow us to reach this goal. We were thus led to explore many possibilities to carry out this analysis and randomly assign patients to the two treatments, as required by the particular nature of these experiments. Specifically, we made a close examination of the methods of randomization, especially appreciating the flexibility of the adaptive responses, and could see the strength

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5

Lui, Wai-fan. "Clinical trials research methodology current practice in Hong Kong and training programme development /." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/HKUTO/record/B38628582.

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6

Čekanauskaitė, Asta. "Informedness about clinical trials of patients participating in placebo-controlled clinical trials in Lithuania." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20130114_081952-77101.

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The dissertation aims to analyse the problem of informed consent in clinical drug trials. Understanding of the provided information is one of the basic components of a person’s sound and informed decision to participate in a clinical trial. Our research evaluated informedness about clinical trials of patients participating in clinical drug trials in Lithuania, with emphasis on the informedness about key elements of clinical trial design (placebo-control, double-blindness, and randomisation). An anonymous survey of patients participating in clinical drug trials was conducted for the purposes of

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7

Kehl, Victoria. "Responder Identification in Clinical Trials." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-5908.

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8

Sydow, Victoria. "Clinical Trials - Competitive resource management." Thesis, KTH, Skolan för bioteknologi (BIO), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-149476.

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9

Murphy, Jeremy James. "Clinical trials in cerebrovascular disease." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293328.

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10

Machin, David. "Statistical aspects of clinical trials." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257667.

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11

Lewis, Nigel da Costa. "Surrogate markers in clinical trials." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620204.

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12

Rahman, Najib. "Clinical trials in pleural disease." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:930991f1-3424-4b96-984e-06df7f6e9204.

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The focus of this thesis is on practice changing clinical studies which impact upon the day to day treatment of patients with pleural infection, answering specific questions on several aspects of patient management. Specific areas of assessment in this thesis include: Assessment of the current evidence for optimal drain size choice in patients with pleural infection; Analysis and statistical modelling of a previous cohort of patients with pleural infection, in order to assess optimal drain size choice in pleural infection; The design, conduct and analysis of a 2 x 2 factorial multi-centre rand

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13

Gatica, Diaz Escobar Gabriel. "Capacity planning under clinical trials uncertainty." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/8400.

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14

Verhagen, Arianne Petra. "Quality assessment of randomised clinical trials." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6863.

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15

Hee, Siew Wan. "Designing a series of clinical trials." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/50306/.

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This thesis presents designs for a series of clinical trials where instead of designing clinical trials individually, each of the trials is designed as part of a series of trials. The framework of the design is based on a combination of classical frequentist and Bayesian approaches which is sometimes known as the hybrid approach. The unknown parameter of the treatment efficacy is assumed to be random and follows a prior distribution in the design stage but at the end of the trial a frequentist test statistic is used on the observed data to infer the parameter. The design introduced in Chapter

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16

殷小曼 and Shiu-man Yolanda Yan. "Patient recruitment strategies in clinical trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970874.

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17

MaÌrquez, Elsa ValdeÌs. "Inference in covariate-adaptive clinical trials." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425222.

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18

Rothwell, Joanne C. "Quantifying effect sizes in clinical trials." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20924/.

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Introduction: This thesis discusses the importance of the target effct size (ES) used in clinical trials of health interventions. It investigates the common methods of eliciting the target difference and whether target values are optimistic or unrealistic. Regression to the mean (RTM) is shown for trials in sequence, which is assessed through simulations and an adjustment developed to adapt for this bias. Research Question: Investigating currently used methods for eliciting the target difference and optimal methods for adjusting for RTM. Methods: Firstly, a review of the Health Technology Asse

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19

Hodkinson, Alexander. "Assessments of harms in clinical trials." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2023762/.

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Introduction and Aims Healthcare interventions are usually associated with a risk of harmful events that must be balanced against the potential favorable outcomes. However reliable evidence on harms for interventions is often inadequate, and hampered by the many challenges that stem from the reporting, analysis and interpretation of harms data in clinical trials. This thesis addresses some of these issues. Methods Reporting of harms data is assessed in a systematic review of reviews and a case study investigating the additional value of harms data reported in clinical study reports (CSRs). A f

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20

Yan, Shiu-man Yolanda. "Patient recruitment strategies in clinical trials." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24872623.

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21

Henderson, Neil James Kerr. "Extending the clinical and economic evaluations of a randomised controlled trial the IONA study /." Connect to e-thesis, 2008. http://theses.gla.ac.uk/418/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Department of Statistics, Faculty of Information and Mathematical Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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22

Ghersi, Davina. "Issues in the design, conduct and reporting of clinical trials that impact on the quality of decision making." Phd thesis, School of Public Health, 2006. http://hdl.handle.net/2123/6653.

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23

Chan, Hung-kin Clive. "A multi-dimensional survey and critical analysis of clinical trial regulations in Hong Kong and a comparison of the status of clinical trial regulations in some Asian countries/Regions." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971465.

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24

Kilgore, Meredith L. "Effects of trial design on participation and costs in clinical trials : with an examination of cost analysis methods and data sources /." Santa Monica, Calif. : Pardee RAND Graduate School, 2004. http://www.rand.org/publications/RGSD/RGSD179.

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25

Zhao, Yufan Kosorok Michael R. "Reinforcement learning design for cancer clinical trials." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2857.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biostatistics, School of Public Health." Discipline: Biostatistics; Department/School: Public Health.

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26

Millar, Joanne Ruth. "Early clinical trials in upper gastrointestinal cancer." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492011.

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On a worldwide basis, gastric and oesophageal cancer are the third and seventh most common causes of cancer respectively. The majority of patients either present with locally advanced I inoperable or metastatic disease, or develop recurrent disease after potentially curative management. Palliative chemotherapy is therefore a consideration for the majority of patients. Standard chemotherapy in this setting using cisplatin and fluorouracil based regimens does improve survival. However, to date, no randomised trial has shown survival beyond 12 months. There has therefore been considerable early t

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27

Tan, Say Beng. "Bayesian decision theoretic methods for clinical trials." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312988.

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28

Harwood, Susan Elizabeth. "Medication compliance in out-patient clinical trials." Thesis, University of Sunderland, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330315.

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29

Bamias, Christina. "Analysis of clinical trials with rescue medication." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249574.

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30

Qian, Wendi. "Bayes methods in group sequential clinical trials." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263693.

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31

Todd, Susan Clare. "Methods of analysis for sequential clinical trials." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239477.

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32

Warne, David W. "Bayesian design and analysis of clinical trials." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303459.

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33

Burnett, Thomas. "Bayesian decision making in adaptive clinical trials." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760912.

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The key original contribution of this work is the use of a Bayes optimisation framework for the decision made at the interim analysis of Adaptive Enrichment trials. Adaptive Enrichment designs make efficient use of pre-identified patient sub-populations. They begin by recruiting from all eligible patients, then at a pre-planned interim analysis select which sub-populations will be recruited from for the remainder of the sample. We ensure strong control of the Familywise Error Rate whichever sub-populations are selected by constructing an overall hypothesis testing structure using both closed t

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34

Miller, Michael G. (Michael Gahuse). "Optimal allocation of resources to clinical trials." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10670.

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35

Cotterill, Amy. "Novel methods for early phase clinical trials." Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/75558/.

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Early phase clinical trials are conducted with limited time and patient resources. Despite design restrictions, patient safety must be prioritised and trial conclusions must be accurate; maximising a promising treatment’s chance of success in later largescale, long-term trials. Increasing the efficiency of early phase clinical trials, through utilising available data more effectively, can lead to improved decision making during, and as a result of, the trial. This thesis contains three distinct pieces of research; each of which proposes a novel, early phase clinical trial design with this over

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36

Oliveira, Liliana Cristina Santos. "Curricular training report about clinical trials monitoring." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10578.

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Mestrado em Biomedicina Farmacêutica<br>O presente relatório propõe-se a apresentar as atividades desenvolvidas durante um estágio curricular de 10 meses na Datamedica CRO Full Service. A estagiária encontrava-se a desenvolver atividades de monitorização de ensaios clínicos na empresa recetora pelo que este será o principal enfoque deste trabalho. Após 6 meses de estágio curricular, a Astellas Farma Lda subcontratou à Datamedica a estagiária em questão para desempenhar a função de CRA o que permitiu conhecer o mundo dos ensaios clínicos de duas diferentes perspetivas - a das grandes empresas d

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37

Al-Qasem, Leena. "Exploitation and clinical trials in developing countries." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/1190/.

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This thesis discusses comprehensively the issue of exploitation from a normative perspective specifically relating to clinical trials within developing countries using a normative definition. Exploitation is defined from an unfairness perspective as the unfair use of an individual (group of individual) by another. In order to ease the flow of the arguments within this thesis, unfairness will be assessed from two different perspectives: a procedural perspective and an outcome perspective. The procedural perspective discusses whether the procedures followed when obtaining informed consent from t

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38

Thach, Chau Thuy. "Self-designing optimal group sequential clinical trials /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9585.

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39

Kittelson, John Martin. "The design of group sequential clinical trials." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290621.

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Group sequential clinical trials have become the accepted method for monitoring the results of an ongoing trial. These methods allows early termination of a trial based on the results of "interim analyses" that are conducted after each of the groups of subjects are entered on the study. Existing methods for designing these types of trials are currently comprised of several different constructions, each of which addresses a different clinical setting. The purpose of this dissertation is to unify these constructions into a single framework. This is accomplished by first proposing a general algeb

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40

Menezes, Prema Miller William C. "Is there a trial effect in HIV clinical trials? identifying who participates in clinical trials and assessing the effect of trial participation on the response to highly active antiretroviral therapy /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2061.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.

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41

Ali, Myzoon. "The Virtual International Stroke Trials Archive (VISTA) : promulgation of a clinical trial resource." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/509/.

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Abstract Chapter 1 provides an introduction to stroke including its current prevalence both nationally and globally, aetiology, global importance and social & financial burden. We also describe here current acute stroke management practices, the role of clinical trials in the development of therapies, the richness of data within clinical trials and changes in regulatory thinking regarding data access. We provide recommendations for the use of trial data for novel exploratory investigations of clinical trial design and epidemiological studies. In Chapter 2 we describe the establishment of the V

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42

Leite, Diana Filipa Gomes. "Curricular training at a phase I clinical trials unit." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13278.

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Mestrado em Biomedicina Farmacêutica<br>This report describes a curricular training in a Phase I Clinical Trials Unit, Blueclinical Ltd, company with different business areas in clinical research. Regarding clinical research, an overview of the traditional and the new paradigm of pharmaceutical development is present as well Phase I and Bioequivalence clinical trials details, the European and Portuguese regulatory environment. During the training, I participated in nine clinical trial submissions to Portuguese Competent Authorities. I also participated in the conduction of five bioequivalenc

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43

Hon, Wai-fan. "Fraud in clinical research : perceptions among clinical investigators and biomedical researchers /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38478584.

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44

Loudon, Kirstine. "PRECIS-2 : making trials matter : providing an empirical basis for the selection of pragmatic design choices in clinical trials." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/af271d88-4652-41e0-b280-4772cc30f8c4.

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Aim PRECIS (PRagmatic Explanatory Continuum Indicator Summaries 2009) is a tool with a simple wheel format that trialists can use when designing their trials to improve the applicability of results but users highlighted problems. The aim of the study was to produce an improved and validated version of PRECIS, called PRECIS-2 and test this tool out with trial teams designing primary care trials. Methods Brainstorming and a 2-round Delphi survey of authors who cited PRECIS plus user-testing of candidate PRECIS-2 models was followed by validity and reliability testing of the most promising PRECIS

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45

Salgueiro, Ana Cláudia Marques. "Curricular training in coordination of clinical trials in a clinical research unit." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14285.

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Mestrado em Medicina Farmacêutica<br>This report describes several activities and projects developed in the context of a curricular training in a clinical research unit, Centro de Investigação Clínica (CIC), led by Professor Joaquim Ferreira. The CIC is one of the research groups of Instituto de Medicina Molecular (IMM) and it is also a group of the Centro Académico de Medicina de Lisboa (CAML) consortium. The principal area of training was the coordination of clinical trials and observational studies. Additionally, other research activities were conducted during the training such as, pharmac

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46

Sakamoto, Junichi, and Satoshi Morita. "From Translational Research to a Large Randomized Clinical Trial : A Long and Streanuous Way from Bench to Bedside." Nagoya University School of Medicine, 2007. http://hdl.handle.net/2237/7473.

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47

Witt, John R. "Equipoise and Skepticism: Past, Present and Future." Thesis, Connect to resource online, 2008. http://hdl.handle.net/1805/1674.

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Thesis (M.A.)--Indiana University, 2008.<br>Title from screen (viewed on June 2, 2009). Department of Philosophy, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Eric Mark Meslin, John J. Tilley, Timothy D. Lyons. Includes vita. Includes bibliographical references (leaves 48-52).

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48

Bari, Wasimul. "Analyzing binary longitudinal data in adaptive clinical trials /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,167453.

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49

Bailey, Stuart Michael. "Sequential adaptive designs for early phase clinical trials." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445626.

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50

Zhang, Paul. "Multiple imputation of missing data in clinical trials." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63596.pdf.

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