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Journal articles on the topic 'Clock intent'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Caruso, Eugene M., Zachary C. Burns, and Benjamin A. Converse. "Slow motion increases perceived intent." Proceedings of the National Academy of Sciences 113, no. 33 (2016): 9250–55. http://dx.doi.org/10.1073/pnas.1603865113.

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To determine the appropriate punishment for a harmful action, people must often make inferences about the transgressor’s intent. In courtrooms and popular media, such inferences increasingly rely on video evidence, which is often played in “slow motion.” Four experiments (n = 1,610) involving real surveillance footage from a murder or broadcast replays of violent contact in professional football demonstrate that viewing an action in slow motion, compared with regular speed, can cause viewers to perceive an action as more intentional. This slow motion intentionality bias occurred, in part, beca

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Inupakutika, D., M. Nadim, G. R. Gunnam, et al. "Integration of NLP and Speech-to-text Applications with Chatbots." Electronic Imaging 2021, no. 3 (2021): 35–1. http://dx.doi.org/10.2352/issn.2470-1173.2021.3.mobmu-035.

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With the evolving artificial intelligence technology, the chatbots are becoming smarter and faster lately. Chatbots are typically available round the clock providing continuous support and services. A chatbot or a conversational agent is a program or software that can communicate using natural language with humans. The challenge of developing an intelligent chatbot still exists ever since the onset of artificial intelligence. The functionality of chatbots can range from business oriented short conversations to healthcare intervention based longer conversations. However, the primary role that t

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Sartorelli, Lorenzo Silvestrin, Rubens José Bombardi Neto, Marina Gobbe Mosqueta-Pinheiro, et al. "Blood melatonin level can serve as a potential biomarker for prostate and hepatocellular carcinomas." Melatonin Research 4, no. 2 (2021): 253–69. http://dx.doi.org/10.32794/mr11250094.

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Many systemic functions display circadian rhythms driven by an endogenous mechanism that is regulated by circadian-related genes and these gene expressions control a central clock in the brain and subordinate clocks in peripheral tissues. However, modern life has introduced environmental factors that often interfere with natural circadian rhythms. Importantly, circadian disruption has been identified as an independent risk factor of cancers. Melatonin is a major circadian rhythm regulator. In cancer patients, the rhythm of melatonin is often disrupted and its level is also reduced. These chang

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Smith-Berdan, Stephanie, Daphne Gille, Irving L. Weissman, and Julie L. Christensen. "Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells." Blood 110, no. 4 (2007): 1370–78. http://dx.doi.org/10.1182/blood-2007-03-081497.

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Abstract Patients with severe systemic lupus erythematosus (SLE) refractory to conventional treatment are candidates for autologous hematopoietic stem cell (HSC) transplantation if the intent is to reset the immunologic clock. These patients might be candidates for allotransplantation with (SLE)-resistant major histocompatibility complex (MHC) haplotype-matched HSC if partial or complete replacement of an autoimmune-prone system is the intent. Using lupus-prone New Zealand black × New Zealand white (NZBW) mice, we investigated the use of highly enriched, haplomismatched, allogeneic HSC to prev

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Maloni, Michael J., David M. Gligor, Robin A. Cheramie, and Elizabeth M. Boyd. "Supervisor and mentoring effects on work-family conflict in logistics." International Journal of Physical Distribution & Logistics Management 49, no. 6 (2019): 644–61. http://dx.doi.org/10.1108/ijpdlm-12-2017-0389.

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Purpose A talent shortage and underrepresentation of women in logistics emphasize the need to assess the logistics work culture. As logistics practitioners face round-the-clock job pressures, work–family conflict presents one such opportunity for study. Consequently, the purpose of this paper is to assess the impact of supervisors and mentoring on work interference with family (WIF) and subsequent job satisfaction and intent to leave logistics. Design/methodology/approach Under role conflict theory, the authors apply structural equation modeling to survey data of logistics practitioners, focus

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Xu, Beizhen, Lei Wang, Wenju Fu, Ruizhi Chen, Tao Li, and Xinxin Zhang. "A Practical Adaptive Clock Offset Prediction Model for the Beidou-2 System." Remote Sensing 11, no. 16 (2019): 1850. http://dx.doi.org/10.3390/rs11161850.

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The predicted navigation satellite clock offsets are crucial to support real-time global navigation satellite system (GNSS) precise positioning applications, especially for those applications difficult to access the real-time data stream, such as the low earth orbit (LEO) autonomous precise orbit determination. Currently, the clock prediction for the Chinese BeiDou system is still challenging to meet the precise positioning requirement. The onboard clocks of BeiDou satellites are provided by different manufacturers, and the clocks’ switch events are more frequent. Considering the satellite-spe

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Park, Demian, and Leslie C. Griffith. "Electrophysiological and Anatomical Characterization of PDF-Positive Clock Neurons in the Intact Adult Drosophila Brain." Journal of Neurophysiology 95, no. 6 (2006): 3955–60. http://dx.doi.org/10.1152/jn.00117.2006.

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Daily biological rhythms in both prokaryotes and eukaryotes are controlled by circadian clocks. In Drosophila, there is a good basic understanding of both the molecular and anatomical components of the clock. In this study we directly measure, for the first time, electrophysiological properties and anatomy of individual filled large lateral PDF-positive clock neurons, a cell group believed to be involved in synchronization of the clock in constant conditions. We find that the large PDF-positive neurons are morphologically homogeneous and that their resting membrane potential is modulated both

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Manella, Gal, Rona Aviram, Nityanand Bolshette, et al. "Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment." Proceedings of the National Academy of Sciences 117, no. 1 (2019): 779–86. http://dx.doi.org/10.1073/pnas.1914112117.

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The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transcriptional response to acute hypoxia is tissue-specific and time-of-day–dependent. In particular, clock components differentially responded at the transcriptional and posttranscriptional level, and these responses depended on an intact circadian clock. Importantly, exposure to hypo

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Macko, Dominik, Katarína Jelemenská, and Pavel Čičák. "Verification of Power-Management Specification at Early Stages of Power-Constrained Systems Design." Journal of Circuits, Systems and Computers 26, no. 08 (2017): 1740002. http://dx.doi.org/10.1142/s0218126617400023.

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Nowadays, power is a dominant factor that constrains highly integrated hardware-systems designs. The implied problems of high power density, causing chip overheating, or limited power source in modern Internet-of-Things devices are most commonly dealt with the use of the dynamic power management. This method enables to use power-reduction techniques, such as clock gating, power gating, or voltage and frequency scaling. Since the adoption of power management is quite difficult in modern complex systems, there are new approaches evolving intended to simplify power-constrained systems design. We

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Becattini-Oliveira, Ana Cláudia, Leonardo Cardoso Portela Câmara, Douglas de Farias Dutra, Antonia de Azevedo Falcão Sigrist, and Helenice Charchat-Fichman. "Performance-based instrument to assess functional capacity in community-dwelling older adults." Dementia & Neuropsychologia 13, no. 4 (2019): 386–93. http://dx.doi.org/10.1590/1980-57642018dn13-040004.

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ABSTRACT Functional capacity (FC) is a mediator between neuropsychological functions and real-world functioning, but there is a lack of evidence of its correlation in community-dwelling older adults. Objective: The study aim was to determine the FC level of community-dwelling older adults using the UCSD Performance-based Skills Assessment (UPSA) and to evaluate correlation with cognitive screening tests. Methods: Senior center participants were selected according to inclusion criteria: Portuguese fluency, age ≥60 years and self-reported independent living. The subject exclusion criteria were:

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Durgan, David J., Margaret A. Hotze, Tara M. Tomlin, et al. "The intrinsic circadian clock within the cardiomyocyte." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 4 (2005): H1530—H1541. http://dx.doi.org/10.1152/ajpheart.00406.2005.

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Circadian clocks are intracellular molecular mechanisms that allow the cell to anticipate the time of day. We have previously reported that the intact rat heart expresses the major components of the circadian clock, of which its rhythmic expression in vivo is consistent with the operation of a fully functional clock mechanism. The present study exposes oscillations of circadian clock genes [brain and arylhydrocarbon receptor nuclear translocator-like protein 1 ( bmal1), reverse strand of the c-erbaα gene ( rev-erbaα), period 2 ( per2), albumin D-element binding protein ( dbp)] for isolated adu

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BATTELLE, BARBARA-ANNE, CHRISTOPHER D. WILLIAMS, JERI-LYNN SCHREMSER-BERLIN, and CHELSI CACCIATORE. "Regulation of arrestin mRNA levels in Limulus lateral eye: Separate and combined influences of circadian efferent input and light." Visual Neuroscience 17, no. 2 (2000): 217–27. http://dx.doi.org/10.1017/s0952523800172049.

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Most animals experience daily changes in light and darkness. The retinas of many of these animals show concomitant rhythmic changes in the levels of mRNAs that encode proteins involved in the photoresponse. These changes may be circadian and independent of light, independent of circadian clocks and regulated by light, or regulated by a circadian clock and light. We have taken advantage of the organization of the Limulus visual system to examine the separate and combined effects of signals from a circadian clock and light on arrestin mRNA levels in photoreceptors. The clock that regulates photo

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Rehman, Ubaid Ur, Dong Jin Chang, Younhea Jung, Usman Akhtar, Muhammad Asif Razzaq, and Sungyoung Lee. "Medical Instructed Real-Time Assistant for Patient with Glaucoma and Diabetic Conditions." Applied Sciences 10, no. 7 (2020): 2216. http://dx.doi.org/10.3390/app10072216.

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Virtual assistants are involved in the daily activities of humans such as managing calendars, making appointments, and providing wake-up calls. They provide a conversational service to customers around-the-clock and make their daily life manageable. With this emerging trend, many well-known companies launched their own virtual assistants that manage the daily routine activities of customers. In the healthcare sector, virtual medical assistants also provide a list of relevant diseases linked to a specific symptom. Due to low accuracy and uncertainty, these generated recommendations are untruste

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ROY, Rakesh. "Role of palliative care department in modifying ICU admissions for patients with advanced cancer: A study." Journal of Clinical Oncology 30, no. 15_suppl (2012): e19517-e19517. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e19517.

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e19517 Background: Admission of cancer patients are on the rise in the Intensive Care Unit due to advancement in healthcare facilities. But limited number of ICU beds, health resources and lack of structured Palliative Care services are a matter of concern. Methods: A retrospective study was conducted in an Indian tertiary cancer centre from Jan – Jun 2010 to find out total number and cause of ICU admission of advanced cancer patients when a Palliative Care Department did not exist. Information source were case files and interviews after appropriate consent. Exclusion criteria - age < 18 ye

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Lande-Diner, Laura, Jacob Stewart-Ornstein, Charles J. Weitz, and Galit Lahav. "Single-cell analysis of circadian dynamics in tissue explants." Molecular Biology of the Cell 26, no. 22 (2015): 3940–45. http://dx.doi.org/10.1091/mbc.e15-06-0403.

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Tracking molecular dynamics in single cells in vivo is instrumental to understanding how cells act and interact in tissues. Current tissue imaging approaches focus on short-term observation and typically nonendogenous or implanted samples. Here we develop an experimental and computational setup that allows for single-cell tracking of a transcriptional reporter over a period of >1 wk in the context of an intact tissue. We focus on the peripheral circadian clock as a model system and measure the circadian signaling of hundreds of cells from two tissues. The circadian clock is an autonomous os

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Li, Xiao, Ye-Yi Wang, Dou Shen, and Alex Acero. "Learning with click graph for query intent classification." ACM Transactions on Information Systems 28, no. 3 (2010): 1–20. http://dx.doi.org/10.1145/1777432.1777435.

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Cordes, Sara, and C. R. Gallistel. "Intact interval timing in circadian CLOCK mutants." Brain Research 1227 (August 2008): 120–27. http://dx.doi.org/10.1016/j.brainres.2008.06.043.

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Chen, Jia, Jiaxin Mao, Yiqun Liu, et al. "A Hybrid Framework for Session Context Modeling." ACM Transactions on Information Systems 39, no. 3 (2021): 1–35. http://dx.doi.org/10.1145/3448127.

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Understanding user intent is essential for various retrieval tasks. By leveraging contextual information within sessions, e.g., query history and user click behaviors, search systems can capture user intent more accurately and thus perform better. However, most existing systems only consider intra-session contexts and may suffer from the problem of lacking contextual information, because short search sessions account for a large proportion in practical scenarios. We believe that in these scenarios, considering more contexts, e.g., cross-session dependencies, may help alleviate the problem and

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Levesque, John M. "Reservoir Simulation on Supercomputers." Society of Petroleum Engineers Journal 25, no. 02 (1985): 275–79. http://dx.doi.org/10.2118/10520-pa.

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Abstract Several important excerpts from reservoir models have been tested on the Cray-1 and Cyber 205. The timings of these kernels are examined and explained by analyzing the architectural differences of the two machines. Interesting conclusions as to the strengths and weaknesses of the two machines are drawn. Introduction In the past 2 years, the Cray-1 has asserted itself in the petroleum industry as an extremely valuable tool for petroleum industry as an extremely valuable tool for reservoir simulation and geophysical data analysis. Recent analysis of the capabilities of the Cyber 205 ind

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Xiang, S., L. Mao, T. Duplessis, et al. "Oscillation of Clock and Clock Controlled Genes Induced by Serum Shock in Human Breast Epithelial and Breast Cancer Cells: Regulation by Melatonin." Breast Cancer: Basic and Clinical Research 6 (January 2012): BCBCR.S9673. http://dx.doi.org/10.4137/bcbcr.s9673.

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This study investigates differences in expression of clock and clock-controlled genes (CCGs) between human breast epithelial and breast cancer cells and breast tumor xenografts in circadian intact rats and examines if the pineal hormone melatonin influences clock gene and CCG expression. Oscillation of clock gene expression was not observed under standard growth conditions in vitro, however, serum shock (50% horse serum for 2 h) induced oscillation of clock gene and CCG expression in MCF-10A cells, which was repressed or disrupted in MCF-7 cells. Melatonin administration following serum shock

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Kireeva, Galina, Yekaterina Gubareva, Natalya Mityushkina, et al. "THE STUDY OF CIRCADIAN RHYTHMS IN OVARIAN CANCER RAT MODEL: IS THERE CONNECTION BETWEEN TUMOR DEVELOPMENT AND RHYTHMICITY DISRUPTION IN INTACT TISSUES?" Problems in oncology 65, no. 6 (2019): 889–97. http://dx.doi.org/10.37469/0507-3758-2019-65-6-889-897.

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Considering emerging yet contradictory data on circadian rhythms disruption and its effects on tumor initiation and progression, we performed in vivo study to evaluate changes (if any) in clock genes expression in tumor compared to intact tissues as well as to see if tumor development affects normal tissues in tumor-bearing animals. The study was performed in 75 female Wistar rats, intraperitoneally transplanted ovarian cancer was used as a tumor model. Tumor-bearing rats had fragmented circadian rhythmicity of their locomotor activity compared to intact animals. No circadian rhythmicity in pr

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KHADILKAR, RASHMI V., JOHN R. MYTINGER, LAURA E. THOMASON, SCOTT L. RUNYON, KEVIN J. WASHICOSKY, and ROBERT N. JINKS. "Central regulation of photosensitive membrane turnover in the lateral eye of Limulus. I. Octopamine primes the retina for daily transient rhabdom shedding." Visual Neuroscience 19, no. 3 (2002): 283–97. http://dx.doi.org/10.1017/s0952523802192066.

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Limulus lateral eyes shed and renew a portion of their photosensitive membrane (rhabdom) daily. Shedding, in many species including Limulus, is regulated by complex interactions between circadian rhythms and light. Little is known about how circadian clocks and photoreceptors communicate to regulate shedding. Limulus photoreceptors do not contain an endogenous circadian oscillator, but rely upon efferent outflow from a central clock for circadian timing. To investigate whether the putative efferent neurotransmitter octopamine (OA) communicates circadian rhythms that prime the lateral eye for t

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OISHI, Katsutaka, Hidenori SHIRAI та Norio ISHIDA. "CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor α (PPARα) in mice". Biochemical Journal 386, № 3 (2005): 575–81. http://dx.doi.org/10.1042/bj20041150.

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PPARα (peroxisome-proliferator-activated receptor α) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that regulate the expression of genes associated with lipid metabolism. In the present study, we show that circadian expression of mouse PPARα mRNA requires the basic helix–loop–helix PAS (Per-Arnt-Sim) protein CLOCK, a core component of the negative-feedback loop that drives circadian oscillators in mammals. The circadian expression of PPARα mRNA was abolished in the liver of homozygous Clock mutant mice. Using wild-type and Clock-deficient fibroblasts

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Knoedler, Joseph R., José Ávila-Mendoza, Arasakumar Subramani, and Robert J. Denver. "The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp." Journal of Biological Rhythms 35, no. 3 (2020): 257–74. http://dx.doi.org/10.1177/0748730420913205.

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An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modulate transcription of the clock-output gene Dbp. Our earlier genome-wide analysis of the mouse hippocampus-derived cell line HT22 showed that KLF9 associates in chromatin with Per1, Per3, Dbp, Tef, Bhlhe40, Bhlhe41, Nr1d1, and Nr1d2. Of the 3514 KLF9 peaks identified in HT22 cells

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Shakhmantsir, Iryna, Scott J. Dooley, Siddharth Kishore, et al. "RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation." Journal of Biological Rhythms 35, no. 1 (2019): 72–83. http://dx.doi.org/10.1177/0748730419887876.

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Circadian clocks regulate multiple physiological processes in the eye, but their requirement for retinal health remains unclear. We previously showed that Drosophila homologs of spliceosome proteins implicated in human retinitis pigmentosa (RP), the most common genetically inherited cause of blindness, have a role in the brain circadian clock. In this study, we report circadian phenotypes in murine models of RP. We found that mice carrying a homozygous H2309P mutation in Pre-mRNA splicing factor 8 ( Prpf8) display a lengthened period of the circadian wheel-running activity rhythm. We show also

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Xiong, Wei, Michael Recce, and Brook Wu. "Intent-Based User Segmentation with Query Enhancement." International Journal of Information Retrieval Research 3, no. 4 (2013): 1–17. http://dx.doi.org/10.4018/ijirr.2013100101.

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With the rapid advancement of the internet, accurate prediction of user's online intent underlying their search queries has received increasing attention from online advertising community. This paper aims to address the major challenges with user queries in the context of behavioral targeting advertising by proposing a query enhancement mechanism that augments user's queries by leveraging a user query log. The empirical evaluation demonstrates that the authors' methodology for query enhancement achieves greater improvement than the baseline models in both intent-based user classification and u

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Zhang, Bo, Xiaoxuan Qi, and Xiaowei Han. "An Advanced User Intent Model Based On User Learning Process." International Journal of Pattern Recognition and Artificial Intelligence 34, no. 09 (2019): 2050024. http://dx.doi.org/10.1142/s021800142050024x.

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User intent analysis is a continuous research hotspot in the field of query expansion. However, the big amount of irrelevant feedbacks in search log has negatively impacted the precision of user intent model. By observing the log, it can be found that tentative click is a major source of irrelevant feedback. It is also observed that a kind of new feedback information can be extracted from the log to recognize the characteristics of tentative clicks. With this new feedback information, this paper proposes an advanced user intent model and applies it into query expansion. Experiment results show

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Yang, Shutong, Aiyi Liu, Adam Weidenhammer, et al. "The Role of mPer2 Clock Gene in Glucocorticoid and Feeding Rhythms." Endocrinology 150, no. 5 (2009): 2153–60. http://dx.doi.org/10.1210/en.2008-0705.

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The circadian clock synchronizes the activity level of an organism to the light-dark cycle of the environment. Energy intake, as well as energy metabolism, also has a diurnal rhythm. Although the role of the clock genes in the sleep-wake cycle is well characterized, their role in the generation of the metabolic rhythms is poorly understood. Here, we use mice deficient in the clock protein mPer2 to study how the circadian clock regulates two critical metabolic rhythms: glucocorticoid and food intake rhythms. Our findings indicate that mPer2−/− mice do not have a glucocorticoid rhythm even thoug

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Kennaway, David J., Julie A. Owens, Athena Voultsios, and Tamara J. Varcoe. "Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independent." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, no. 4 (2006): R1172—R1180. http://dx.doi.org/10.1152/ajpregu.00223.2006.

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The circadian rhythmicity of hormone secretion, body temperature, and sleep/wakefulness results from an endogenous rhythm of neural activity generated by clock genes in the suprachiasmatic nucleus (SCN). One of these genes, Clock, has been considered essential for the generation of cellular rhythmicity centrally and in the periphery; however, melatonin-proficient ClockΔ19 + MEL mutant mice retain melatonin rhythmicity, suggesting that their central rhythmicity is intact. Here we show that melatonin production in these mutants was rhythmic in constant darkness and could be entrained by brief si

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Woodruff, Elizabeth R., Lauren E. Chun, Laura R. Hinds, and Robert L. Spencer. "Diurnal Corticosterone Presence and Phase Modulate Clock Gene Expression in the Male Rat Prefrontal Cortex." Endocrinology 157, no. 4 (2016): 1522–34. http://dx.doi.org/10.1210/en.2015-1884.

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Abstract Mood disorders are associated with dysregulation of prefrontal cortex (PFC) function, circadian rhythms, and diurnal glucocorticoid (corticosterone [CORT]) circulation. Entrainment of clock gene expression in some peripheral tissues depends on CORT. In this study, we characterized over the course of the day the mRNA expression pattern of the core clock genes Per1, Per2, and Bmal1 in the male rat PFC and suprachiasmatic nucleus (SCN) under different diurnal CORT conditions. In experiment 1, rats were left adrenal-intact (sham) or were adrenalectomized (ADX) followed by 10 daily antipha

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Muranaka, Tomoaki, and Tokitaka Oyama. "Heterogeneity of cellular circadian clocks in intact plants and its correction under light-dark cycles." Science Advances 2, no. 7 (2016): e1600500. http://dx.doi.org/10.1126/sciadv.1600500.

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Recent advances in single-cell analysis have revealed the stochasticity and nongenetic heterogeneity inherent to cellular processes. However, our knowledge of the actual cellular behaviors in a living multicellular organism is still limited. By using a single-cell bioluminescence imaging technique on duckweed, Lemna gibba, we demonstrate that, under constant conditions, cells in the intact plant work as individual circadian clocks that oscillate with their own frequencies and respond independently to external stimuli. Quantitative analysis uncovered the heterogeneity and instability of cellula

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Rivkees, S. A., and S. M. Reppert. "Entrainment of circadian phase in developing gray short-tailed opossums: mother vs. environment." American Journal of Physiology-Endocrinology and Metabolism 259, no. 3 (1990): E384. http://dx.doi.org/10.1152/ajpendo.1990.259.3.e384.

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In a marsupial species, the gray short-tailed opossum (Monodelphis domestica), the suprachiasmatic nuclei (SCN), the site of a circadian clock, are formed postnatally and begin oscillating as a circadian clock on day 20. In this study, we examined how the timing (phase) of the SCN clock in the developing opossum is coordinated to the environmental light-dark cycle. When pups were reared from birth in darkness by intact dams, the circadian phases in SCN metabolic activity (monitored by 2-deoxy-D-[14C]glucose autoradiography) in 27-day-old pups were desynchronized. When pups were reared in a lig

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Astiz, Mariana, and Henrik Oster. "Perinatal Programming of Circadian Clock-Stress Crosstalk." Neural Plasticity 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/5689165.

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An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both—from the systemic to the molecular level. Disruption of this interaction by external factors such as shiftwork, jetlag, or chronic stress increases the risk of developing metabolic, immune, or mood disorders. From experiments in rodents, we know that both systems maturate during the perinatal period. During that time, exogenous factors s

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Echalier, Cécile, Anna Rutkowska, Ana Kojic, et al. "amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells." Chemical Communications 57, no. 14 (2021): 1814–17. http://dx.doi.org/10.1039/d0cc06709a.

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Chassard, David, Isabelle Bur, Vincent-Joseph Poirel, Jorge Mendoza, and Valérie Simonneaux. "Evidence for a Putative Circadian Kiss-Clock in the Hypothalamic AVPV in Female Mice." Endocrinology 156, no. 8 (2015): 2999–3011. http://dx.doi.org/10.1210/en.2014-1769.

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Abstract The kisspeptin (Kp) neurons in the anteroventral periventricular nucleus (AVPV) are essential for the preovulatory LH surge, which is gated by circulating estradiol (E2) and the time of day. We investigated whether AVPV Kp neurons in intact female mice may be the site in which both E2 and daily signals are integrated and whether these neurons may host a circadian oscillator involved in the timed LH surge. In the afternoon of proestrous day, Kp immunoreactivity displayed a marked and transient decrease 2 hours before the LH surge. In contrast, Kp content was stable throughout the day o

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Rawashdeh, Oliver, Rex Parsons, and Erik Maronde. "Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory." Neural Plasticity 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/6238989.

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Learning, memory consolidation, and retrieval are processes known to be modulated by the circadian (circa: about; dies: day) system. The circadian regulation of memory performance is evolutionarily conserved, independent of the type and complexity of the learning paradigm tested, and not specific to crepuscular, nocturnal, or diurnal organisms. In mammals, long-term memory (LTM) formation is tightly coupled to de novo gene expression of plasticity-related proteins and posttranslational modifications and relies on intact cAMP/protein kinase A (PKA)/protein kinase C (PKC)/mitogen-activated prote

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Espinosa, Javier, Joseph S. Boyd, Raquel Cantos, Paloma Salinas, Susan S. Golden, and Asuncion Contreras. "Cross-talk and regulatory interactions between the essential response regulator RpaB and cyanobacterial circadian clock output." Proceedings of the National Academy of Sciences 112, no. 7 (2015): 2198–203. http://dx.doi.org/10.1073/pnas.1424632112.

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The response regulator RpaB (regulator of phycobilisome associated B), part of an essential two-component system conserved in cyanobacteria that responds to multiple environmental signals, has recently been implicated in the control of cell dimensions and of circadian rhythms of gene expression in the model cyanobacteriumSynechococcus elongatusPCC 7942. However, little is known of the molecular mechanisms that underlie RpaB functions. In this study we show that the regulation of phenotypes by RpaB is intimately connected with the activity of RpaA (regulator of phycobilisome associated A), the

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Coelho, L. A., R. Peres, and J. Cipolla-Neto. "234 EXPRESSION OF NUCLEAR AND MEMBRANE MELATONIN RECEPTORS GENES AND THE CLOCK GENES IN RAT OOCYTES: PRELIMINARY RESULTS." Reproduction, Fertility and Development 22, no. 1 (2010): 275. http://dx.doi.org/10.1071/rdv22n1ab234.

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There is evidence that melatonin acts directly on the regulation of ovary function. This action is probably attributed in part to melatonin receptors, which are known to be present in granulosa and cumulus cells (Kang J-T et al. 2009 J. Pineal Res. 46, 2228). Melatonin is also known to be associated with the modulation of circadian rhythms and the regulation of seasonal reproductive function (Arendt J 1998 Rev. Reprod. 3, 1322). Circadian rhythms and clock genes appear to be involved in reproductive processes (Dolatshad H et al. 2009 Repro. Fertil. Dev. 21, 19). However, the presence of mel

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Bolten, Catherine. "Rethinking burgeoning political consciousness: student activists, the Class of ‘99 and political intent in Sierra Leone." Journal of Modern African Studies 47, no. 3 (2009): 349–69. http://dx.doi.org/10.1017/s0022278x09003966.

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ABSTRACTThis article uses interviews with former student activists in Sierra Leone to explore what ideals motivate students to participate in political action. In Sierra Leone, students used the military as a cover for their own democratic programme, initially by encouraging a coup that they wanted to partake in, later by joining the officer corps themselves. I challenge the notion that student interactions with the urban lumpenproletariat and ‘militariat’ serve as evidence for their desire to cloak a lack of ideals in popular violence; rather I argue that coalitions are built as needs must to

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Doulabi, B. Zandieh, M. Platvoet-Ter Schiphorst, A. Kalsbeek, E. Fliers, O. Bakker та W. M. Wiersinga. "Diurnal Variation in Rat Liver Thyroid Hormone Receptor (TR)-α Messenger Ribonucleic Acid (mRNA) Is Dependent on the Biological Clock in the Suprachiasmatic Nucleus, whereas Diurnal Variation of TRβ1 mRNA Is Modified by Food Intake". Endocrinology 145, № 3 (2004): 1284–89. http://dx.doi.org/10.1210/en.2003-0791.

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Abstract Previous studies have shown a diurnal variation of certain isoforms of thyroid hormone receptors (TR) in rat liver. The genesis of these diurnal changes is still unknown. To clarify whether the biological clock, located in the hypothalamic suprachiasmatic nucleus (SCN), is involved, we made selective SCN lesions. Rats with an SCN lesion lost their circadian rhythm of plasma corticosterone and TSH when compared with intact animals. TRα1 and TRα2 mRNA expression of control rats was higher in the light period than in the dark period; changes that were abolished in the rats with SCN lesio

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RUNYON, SCOTT L., KEVIN J. WASHICOSKY, RANDALL J. BRENNEMAN*, et al. "Central regulation of photosensitive membrane turnover in the lateral eye ofLimulus. II. Octopamine actsviaadenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding." Visual Neuroscience 21, no. 5 (2004): 749–63. http://dx.doi.org/10.1017/s0952523804215097.

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Why photoreceptors turn over a portion of their photoreceptive membrane daily is not clear; however, failure to do so properly leads to retinal degeneration in vertebrates and invertebrates. Little is known about the molecular mechanisms that regulate shedding and renewal of photoreceptive membrane. Photoreceptor cells in the lateral eye of the horseshoe crabLimulusturn over their photoreceptive membrane (rhabdom) in a brief, synchronous burst in response to dawn each morning. Transient rhabdom shedding (TRS), the first phase of rhabdom turnover inLimulus, is triggered by dawn, but requires a

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Piggins, Hugh. "What makes the brain tick?: The 24-hour clock in mammals." Biochemist 26, no. 1 (2004): 19–21. http://dx.doi.org/10.1042/bio02601019.

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Almost 30 years ago, researchers in the US made the astonishing discovery that destroying a very small structure near the ventral surface of the brain (Figures 1A and 1B), the suprachiasmatic nuclei (SCN) of the hypothalamus, abolished daily (near 24 hour or circadian) behavioural rhythms in rodents1. In intact animals, such oscillations in behaviour and endocrine cycles are sustained when animals are kept under constant conditions (i.e. constant dark, constant temperature, etc.), demonstrating that they are endogenously generated. Remarkably, grafting foetal SCN tissue into the brains of SCN-

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Miyazaki, Koyomi, Miho Mesaki, and Norio Ishida. "Nuclear Entry Mechanism of Rat PER2 (rPER2): Role of rPER2 in Nuclear Localization of CRY Protein." Molecular and Cellular Biology 21, no. 19 (2001): 6651–59. http://dx.doi.org/10.1128/mcb.21.19.6651-6659.2001.

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ABSTRACT Mammalian PERIOD2 protein (PER2) is the product of a clock gene that controls circadian rhythms, because PER2-deficient mice have an arrhythmic phenotype. The nuclear entry regulation of clock gene products is a key step in proper circadian rhythm formation in bothDrosophila and mammals, because the periodic transcription of clock genes is controlled by an intracellular, oscillating, negative feedback loop. The present study used deletion mutants of rat PER2 (rPER2) to identify the functional nuclear localization signal (NLS) in rPER2. The elimination of putative NLS (residues 778 to

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Makovetskaya, Elena, Antonina Deniskina, Egor Krylov, and Fatima Urumova. "Organizational optimization of construction processes by virtue of robotization." E3S Web of Conferences 91 (2019): 02036. http://dx.doi.org/10.1051/e3sconf/20199102036.

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The comparative analysis of two options for investment and construction projects, with partial robotization of production and traditional work organization was conducted on the criterion of time and cost minimizing the of construction. The use of two robot types was considered, a bricklayer and a plasterer robot. As a comparison result of main quantitative indicators of construction organization plan, it was found that the use of robots reduced the duration of construction, expenditures and labor costs. Lack of fatiguability, lunch breaks, smoke breaks, conversations, illnesses, as well as rou

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Woloszynska, Magdalena, Sabine Le Gall, Pia Neyt, et al. "Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators." Proceedings of the National Academy of Sciences 116, no. 16 (2019): 8060–69. http://dx.doi.org/10.1073/pnas.1806541116.

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HISTONE MONOUBIQUITINATION1 (HUB1) and its paralog HUB2 act in a conserved heterotetrameric complex in the chromatin-mediated transcriptional modulation of developmental programs, such as flowering time, dormancy, and the circadian clock. The KHD1 and SPEN3 proteins were identified as interactors of the HUB1 and HUB2 proteins with in vitro RNA-binding activity. Mutants in SPEN3 and KHD1 had reduced rosette and leaf areas. Strikingly, in spen3 mutants, the flowering time was slightly, but significantly, delayed, as opposed to the early flowering time in the hub1-4 mutant. The mutant phenotypes

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Karatsoreos, Ilia N., Matthew P. Butler, Joseph LeSauter, and Rae Silver. "Androgens Modulate Structure and Function of the Suprachiasmatic Nucleus Brain Clock." Endocrinology 152, no. 5 (2011): 1970–78. http://dx.doi.org/10.1210/en.2010-1398.

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Gonadal hormones can modulate circadian rhythms in rodents and humans, and androgen receptors are highly localized within the core region of the mouse suprachiasmatic nucleus (SCN) brain clock. Although androgens are known to modulate neural plasticity in other CNS compartments, the role of androgens and their receptors on plasticity in the SCN is unexplored. In the present study, we ask whether androgens influence the structure and function of the mouse SCN by examining the effects of gonadectomy (GDX) on the structure of the SCN circuit and its responses to light, including induction of cloc

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Smarr, Benjamin L., Emma Morris, and Horacio O. de la Iglesia. "The Dorsomedial Suprachiasmatic Nucleus Times Circadian Expression of Kiss1 and the Luteinizing Hormone Surge." Endocrinology 153, no. 6 (2012): 2839–50. http://dx.doi.org/10.1210/en.2011-1857.

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Ovulation in mammals is gated by a master circadian clock in the suprachiasmatic nucleus (SCN). GnRH neurons represent the converging pathway through which the brain triggers ovulation, but precisely how the SCN times GnRH neurons is unknown. We tested the hypothesis that neurons expressing kisspeptin, a neuropeptide coded by the Kiss1 gene and necessary for the activation of GnRH cells during ovulation, represent a relay station for circadian information that times ovulation. We first show that the circadian increase of Kiss1 expression, as well as the activation of GnRH cells, relies on inta

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Melikyan, Zarui A., Maria M. Corrada, Malcolm B. Dick, Christina Whittle, Annlia Paganini-Hill, and Claudia H. Kawas. "Neuropsychological Test Norms in Cognitively Intact Oldest-Old." Journal of the International Neuropsychological Society 25, no. 05 (2019): 530–45. http://dx.doi.org/10.1017/s1355617719000122.

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AbstractObjectives: Individuals aged 90 or older (oldest-old), the fastest growing segment of the population, are at increased risk of developing cognitive impairment compared with younger old. Neuropsychological evaluation of the oldest-old is important yet challenging in part because of the scarcity of test norms for this group. We provide neuropsychological test norms for cognitively intact oldest-old. Methods: Test norms were derived from 403 cognitively intact participants of The 90+ Study, an ongoing study of aging and dementia in the oldest-old. Cognitive status of intact oldest-old was

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Liu, Peng, Ying Chen, and Chung-Piaw Teo. "Limousine Service Management: Capacity Planning with Predictive Analytics and Optimization." INFORMS Journal on Applied Analytics 51, no. 4 (2021): 280–96. http://dx.doi.org/10.1287/inte.2021.1079.

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Thelimousine service in luxury hotels is an integral component of the whole customer journey in the hospitality industry. One of the largest hotels in Singapore manages a fleet of both in-house and outsourced vehicles around the clock, serving 9,000 trips per month on average. The need for vehicles may scale up rapidly, especially during special events and festive periods in the country. The excess demand is met by having additional outsourced vehicles on standby, incurring millions of dollars of additional expenses per year for the hotel. Determining the required number of limousines by hour

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Fabris, N. "Immune System and Aging: Neuroimmunological Implications." International Journal of Immunopathology and Pharmacology 5, no. 2 (1992): 93–102. http://dx.doi.org/10.1177/039463209200500204.

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Intact neuroendocrine-immune interactions are essential for the development and functional maintenance of both systems. Experimental precocious disruption of such interactions causes premature aging-like phenomena affecting various body functions. Normal physiological aging appears to be, in part, dependent on age-related modifications of neuroendocrine-immune interactions. The thymus plays a major role in this context. Experimental manipulation at the thymic or neuroendocrine level may reciprocally correct the age-associated disfunctions, suggesting the reversible nature of such phenomena. Ba

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