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Journal articles on the topic 'Clorsulon'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ravines, José, Severino Torrel, Amarante Florián Alcántara, Luis Vargas-Rocha, Judit Estela Manrique, and Juan Rojas-Moncada. "Resistance and sensitivity of <i>Fasciola hepatica</i> against four active anthelminticprinciples in guinea pigs (<i>Cavia porcellus</i>), Cajamarca, Peru." Revista de Investigaciones Veterinarias del Perú 35, no. 2 (2024): e22564. http://dx.doi.org/10.15381/rivep.v35i2.22564.

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The study aimed to evaluate the efficacy of four anthelmintics in the control of Fasciola hepatica at the Estación Experimental del Instituto Nacional de Innovación Agraria (INIA), Baños del Inca, Cajamarca, Perú. Forty guinea pigs from 5 to 12 months of age of the Inka line, naturally infected with F. hepatica (≥1 HPG), not dewormed in the last 4 months, under the same management and feeding system were used. The animals were distributed into four groups (n=10): triclabendazole (25 mg/kg) and closantel (20 mg/kg) orally, clorsulon + ivermectin (15 mg/kg based on clorsulon) and nitroxinil (50

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2

Courtney, C. H., J. K. Shearer, and R. E. Plue. "Efficacy and safety of clorsulon used concurrently with ivermectin for control of Fasciola hepatica in Florida beef cattle." American Journal of Veterinary Research 46, no. 6 (1985): 1245–46. https://doi.org/10.2460/ajvr.1985.46.06.1245.

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SUMMARY The safety and anthelmintic efficacy of clorsulon (7 mg/kg of body weight, orally) given concurrently with ivermectin (0.2 mg/kg, subcutaneously) for control of Fasciola hepatica were evaluated in 75 crossbred beef cattle. Twenty-three control animals were given only ivermectin. Fluke egg counts were significantly lower (P < 0.0001) in clorsulon-treated animals by day 14 after treatment than before treatment (base line) and were significantly lower (P < 0.005) after treatment in clorsulon-treated animals than in controls. There was no significant change in fluke egg counts of con

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3

Kilgore, R. L., M. L. Williams, G. W. Benz, and S. J. Gross. "Comparative efficacy of clorsulon and albendazole against Fasciola hepatica in cattle." American Journal of Veterinary Research 46, no. 7 (1985): 1553–55. https://doi.org/10.2460/ajvr.1985.46.07.1553.

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SUMMARY In a dosage-confirmation trial, anthelmintic activities of clorsulon and albendazole against Fasciola hepatica were evaluated and compared. Twenty-eight cattle (8 to 12 months old) with natural F hepatica infections were randomly allotted to 4 groups of 7 cattle each: group 1, no treatment (controls); group 2, clorsulon suspension given orally at 3.5 mg/kg of body weight; group 3, clorsulon suspension given orally at 7 mg/kg; and group 4, albendazole paste given orally at 10 mg/kg. At necropsies, performed 7 and 8 days after treatment, control cattle harbored a geometric mean of 133.2

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Vegad, Kunjal L* Paranjape Dipty B. Shah Dhwani A. Patel Ekta D. Patel Yogesh K. Patel Kaushik R. "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVERMECTIN AND CLORSULON IN IVERCAM INJECTION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 523–31. https://doi.org/10.5281/zenodo.1036490.

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A precise, simple, accurate and selective method was developed and validate for estimation of Ivermectin and Clorsulon in Ivercam injection, Reversed phase high performance liquid chromatographic (RP-HPLC) method was developed for routine quantification of Ivermectin and Clorsulon in laboratory prepared mixtures as well as in combined dosage form. Chromatographic separation was achieved on a BDS hypersil C18 (5μ, 250 x 4.6 mm) utilizing mobile phase of filtered and degassed mixture of 60 phosphate buffer (pH 5.5 adjusted with 1% O-phosphoric acid) and Methanol (60:40 v/v) at a flow rate of 1 m

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5

Sundlof, Stephen F., Ernest L. Bliss, Ellis C. Greiner, Thang Q. Tran, and Mary A. Wertenberger. "Efficacy of clorsulon for the treatment of experimentally induced infections of Fasciola hepatica in goats." American Journal of Veterinary Research 52, no. 1 (1991): 111–14. http://dx.doi.org/10.2460/ajvr.1991.52.01.111.

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SUMMARY A dose titration study was undertaken to determine the efficacy of clorsulon against the adult stage of Fasciola hepatica in goats. Thirty-nine goats were experimentally infected with metacercariae of F hepatica. At 14 weeks after infection, each goat was assigned randomly to 1 of 5 groups. Goats in groups 1 to 4 received a single oral administration of clorsulon at dosages of 3.5, 7, 11, and 15 mg/kg of body weight, respectively. The fifth group of goats (control group) was infected with F hepatica, but were not treated with clorsulon. Postmortem examination of goats at 3 weeks after

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6

Foreyt, William J. "Evaluation of clorsulon against immature Fascioloides magna in cattle and sheep." American Journal of Veterinary Research 49, no. 7 (1988): 1004–6. https://doi.org/10.2460/ajvr.1988.49.07.1004.

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SUMMARY Efficacy of clorsulon was evaluated against infection with immature Fascioloides magna in 24 cattle and 12 sheep. Infections were induced by oral administration of 600 metacercariae/host. In cattle, clorsulon at dosages of 7 and 21 mg/kg of body weight was 65 and 100% effective against 8-week-old flukes, and 20 and 74% effective against 16-week-old flukes, respectively. In sheep, clorsulon at a dosage of 21 mg/kg was 92% effective against 8-week-old flukes. Significantly (P < 0.05) more F magna were recovered from untreated sheep than from untreated cattle.

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7

Ferraroni, Marta, Andrea Angeli, Simone Carradori, and Claudiu T. Supuran. "Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies." Acta Crystallographica Section D Structural Biology 78, no. 3 (2022): 321–27. http://dx.doi.org/10.1107/s2059798322000079.

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Clorsulon is an anthelmintic drug that is clinically used against Fasciola hepatica. Due to the presence of two sulfonamide moieties in its core nucleus, which are well recognized as zinc-binding groups, it was proposed that it may be efficacious in the inhibition of parasite carbonic anhydrases (CAs). Proteomic analyses revealed the presence of CA in the tegument of Schistosoma mansoni, and recently the druggability of this target was explored by testing the inhibitory activities of several sulfonamide-based derivatives. According to the principles of drug repurposing, the aim was to demonstr

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8

Foreyt, William J., and John R. Gorham. "Ineffectiveness of clorsulon against Nanophyetus salmincola in coyotes." Journal of the American Veterinary Medical Association 189, no. 9 (1986): 1101–2. https://doi.org/10.2460/javma.1986.189.09.1101.

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SUMMARY Efficacy of clorsulon against the trematode Nanophyetus salmincola was evaluated in coyotes. Ten 16-week-old coyote pups were fed fish that contained metacercariae of N salmincola. Twenty-one days later, 5 of the coyotes were given a suspension of clorsulon (approx 16 mg/kg of body weight, orally). Within 30 days after treatment, the numbers of fluke eggs in fecal specimens from the 5 treated coyotes had not decreased, and numbers of fluke eggs and flukes recovered from treated coyotes at necropsy did not differ from numbers of fluke eggs and flukes recovered from 5 untreated coyotes.

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9

Conboy, G. A., B. E. Stromberg, and J. C. Schlotthauer. "Efficacy of clorsulon against Fascioloides magna infection in sheep." Journal of the American Veterinary Medical Association 192, no. 7 (1988): 910–12. https://doi.org/10.2460/javma.1988.192.07.910.

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Summary In a study to evaluate the efficacy of clorsulon against Fascioloides magna infection in sheep, 12 ewes were inoculated orally with 100 metacercariae of F magna, and 6 were treated with clorsulon (15 mg/kg of body weight) 8 weeks after inoculation. The sheep were euthanatized 16 weeks after inoculation, flukes were recovered, and the liver and other tissues were subjectively scored for the severity of lesions (0 to 4 + ). The number of flukes recovered from the clorsulon-treated group (3.8 ± 1.2 flukes) was significantly (P = 0.025) lower than the number of flukes recovered from the gr

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10

Zivmerman, Gary L., Dennis H. Wallace, Debra J. Schons, and Eric P. Hoberg. "Efficacy of clorsulon against mature, naturally acquired Fasciola hepatica infections in cattle and sheep." American Journal of Veterinary Research 47, no. 8 (1986): 1665–67. https://doi.org/10.2460/ajvr.1986.47.08.1665.

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SUMMARY Clorsulon (3.5 or 7 mg/kg of body weight) was given orally to mature cows (dairy or beef) and to mature mixed-breed sheep harboring patent infections of Fasciola hepatica. Eighteen animals of each species were assigned to a control group (drug vehicle) or to 1 of 2 treatment (3.5 or 7.0 mg/kg) groups of 6 animals each. On posttreatment days 8 (cows) or 14 (sheep), the animals were slaughtered for recovery of flukes. In cows, the efficacy (P values for treatment groups vs control) of clorsulon against infections of mature F hepatica was 99.21% (P ≤ 0.0065) at 3.5 mg/kg and was 100% (P ≤

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11

Yazwinski, T. A., R. L. Kilgore, B. L. Presson, et al. "Efficacy of oral clorsulon in the treatment of Fasciola hepatica infections in calves." American Journal of Veterinary Research 46, no. 1 (1985): 163–64. https://doi.org/10.2460/ajvr.1985.46.01.163.

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SUMMARY Twenty calves at each of 2 Arkansas locations were inoculated with infective Fasciola hepatica metacercariae. After 56 days, the calves at each site were randomly assigned by weight to 2 treatment groups of 10 calves/group; vehicle control or clorsulon at the rate of 7 mg/kg of body weight. All treatments were given orally as a suspension. Calves were killed 6 weeks after treatment and F hepatica counts were performed for all animals. At the 2 sites, mean levels of efficacy were 96% and 91%. Adverse reactions to clorsulon or the vehicle were not observed in the calves.

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12

Foreyt, W. J., and D. L. Drawe. "Efficacy of clorsulon and albendazole against Fascioloides magna in naturally infected white-tailed deer." Journal of the American Veterinary Medical Association 187, no. 11 (1985): 1187–88. https://doi.org/10.2460/javma.1985.187.11.1187.

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SUMMARY The efficacy of clorsulon and of albendazole against Fascioloides magna were evaluated in 36 naturally infected white-tailed deer (Odocoileus virginianus) in southern Texas. A single oral dose of clorsulon suspension (12 to 30 mg/kg of body weight; mean = 24 mg/kg) was given to each deer and killed 153 (92%) of 167 mature flukes and 4 (80%) of 5 immature flukes recovered at necropsy. A single oral dose of albendazole paste (17 to 46 mg/kg; mean = 26 mg/kg) was given to each deer and killed 148 (89%) of 167 mature flukes and 4 (67%) of 6 immature flukes recovered at necropsy. In 82 nont

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13

Chiu, Shuet Hing Lee, Francis P. Baylis, Rae Taub, Marilyn Green, Bruce A. Halley, and Ralph M. Bodden. "Depletion of [14C]-clorsulon in cows' milk." Journal of Agricultural and Food Chemistry 37, no. 3 (1989): 819–23. http://dx.doi.org/10.1021/jf00087a054.

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14

Maurer, K., M. Decere, and B. Fried. "Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice." Journal of Helminthology 69, no. 4 (1995): 373–74. http://dx.doi.org/10.1017/s0022149x00014991.

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AbstractFemale ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 25 mg/kg, 500 mg/kg and 100 mg/kg) or rafoxanide (50 mg/kg, 25 mg/kg and 5 mg/kg) dissolved in dimethy lsulphoxide (DMSO) carrier and mebendazole (1000mg/kg and 500 mg/kg) or arprinocid (100 mg/kg and 50 mg/kg) suspended in a2:1 polyethylene glycol (PEG)/DMSO carrier. All drugs were obtained from Meerck In. (Rahway, New Jersey, USA) and only single dose regimes were used. Experimentally

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15

Maurer, K., M. Decere, and B. Fried. "Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice." Journal of Helminthology 70, no. 1 (1996): 95–96. http://dx.doi.org/10.1017/s0022149x00015194.

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AbstractFemale ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 500 mg/kg and 100 mg/kg) or rafoxanide (50 mg/kg, 25 mg/kg and 5 mg/kg) dissolved in dimethylsulphoxide (DMSO) carrier and mebendazole (1000 mg/kg and 500 mg/kg) or arprinocid (100 mg/kg and 50 mg/kg) suspended in a 2:1 polyethylene glycol (PEG)/DMSO carrier. All drugs were obtained from Merck Inc. (Rahway, New Jersey, USA) and only single dose regimes were used. Experimentally infected

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16

Al-nami, Samar Y., Enas Aljuhani, Salhah D. Al-Qahtani, et al. "Novel clorsulon voltammetric sensors based on zinc oxide nanostructure." Journal of Saudi Chemical Society 26, no. 3 (2022): 101444. http://dx.doi.org/10.1016/j.jscs.2022.101444.

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17

Gatto, Gregory J., and Holly E. Mertel. "Synthesis of carbon-14 and sulfur-35 labeled clorsulon." Journal of Labelled Compounds and Radiopharmaceuticals 28, no. 8 (1990): 943–53. http://dx.doi.org/10.1002/jlcr.2580280808.

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18

Sivanandham, Natarajan, and Kempegowda Bommanadoddi Kempegowda. "Investigation and Characterization of New Impurity in Clorsulon Drug Substance." Current Pharmaceutical Analysis 14, no. 4 (2018): 360–66. http://dx.doi.org/10.2174/1573412913666170526160915.

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19

SUNDLOF, S. F., and T. W. WHITLOCK. "Clorsulon pharmacokinetics in sheep and goats following oral and intravenous administration." Journal of Veterinary Pharmacology and Therapeutics 15, no. 3 (1992): 282–91. http://dx.doi.org/10.1111/j.1365-2885.1992.tb01018.x.

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Fetterer, R. H., R. S. Rew, L. C. Gasbarre, and D. A. Ostlind. "Prophylactic efficacy of clorsulon against Fasciola hepatica in calves and sheep." Veterinary Parasitology 18, no. 1 (1985): 21–27. http://dx.doi.org/10.1016/0304-4017(85)90004-4.

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21

Rehbein, S., and M. Visser. "Efficacy of an injectable ivermectin/clorsulon combination against Fasciola hepatica in sheep." Veterinary Record 145, no. 16 (1999): 468. http://dx.doi.org/10.1136/vr.145.16.468.

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22

Emmerich, I. U. "Neue Arzneimittel für Pferde und landwirtschaftliche Nutztiere 2011." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 40, no. 05 (2012): 301–8. http://dx.doi.org/10.1055/s-0038-1623131.

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ZusammenfassungIm Jahr 2011 kamen für Pferde und landwirtschaftliche Nutztiere drei neue Wirkstoffe auf den deutschen Tierarzneimittelmarkt. Bei zwei der neuen Präparate handelte es sich um Antibiotika verschiedener Wirkstoffklassen, das Polypeptidantibiotikum Bacitracin (BacivetTM) und das Makrolid Tildipirosin (Zuprevo®). Das dritte Arzneimittel mit einem neuen Wirkstoff war das neue Fasziolizid Clorsulon (Levatum®). Drei Wirkstoffe erhielten eine Tierartenerweiterung. So wurde das nichtsteroidale Antiphlogistikum Natriumsalicylat auch für Puten und das Makrolidantibiotikum Tilmicosin ebenso

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Oliveira, Plinio Aguiar, Diego Moscarelli Pinto, Jerônimo Lopes Ruas, et al. "EFICÁCIA DE DIFERENTES FÁRMACOS NO CONTROLE PARASITÁRIO EM OVINOS." Science And Animal Health 2, no. 2 (2014): 126. http://dx.doi.org/10.15210/sah.v2i2.3039.

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As parasitoses intestinais são um grande problema na ovinocultura, pois levam os produtores a utilizar anti-helmínticos em excesso, contribuindo para o desenvolvimento da resistência. Este trabalho objetivou avaliar a eficácia anti-helmíntica de diferentes princípios ativos no controle de nematódeos gastrintestinais de um rebanho ovino do Alto Uruguai Catarinense, Oeste de Santa Catarina. Foram utilizadas 82 fêmeas ovinas da raça Texel distribuídas em dois grupos controle e outros seis para testar os seguintes fármacos: closantel, triclorfon, albendazol, disofenol, levamisol, moxidectina, iver

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Coles, G. C., and K. A. Stafford. "Activity of oxyclozzanide, nitroxynil, clorsulon and albendazole against adult triclabendazole resistant Fasciola hepatica." Veterinary Record 148, no. 23 (2001): 723–24. http://dx.doi.org/10.1136/vr.148.23.723.

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Mahmoud, Fagr, Sameh EI-Nabtity, and Fatma Gaber. "COMPARATIVE STUDY ON IVERMECTIN PLUS CLORSULON AND NITROXYNIL IN TREATMENT OF FASCIOLIASIS IN CATTLE." Zagazig Journal of Pharmaceutical Sciences 17, no. 1 (2008): 22–29. http://dx.doi.org/10.21608/zjps.2008.169362.

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Schenck, Frank J., Steven A. Barker, and Austin R. Long. "Matrix Solid Phase Dispersion (MSPD) Isolation and Liquid Chromatographic Determination of Clorsulon in Milk." Journal of Liquid Chromatography 14, no. 15 (1991): 2827–34. http://dx.doi.org/10.1080/01483919108049360.

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Markus, John, and Joseph Sherma. "Method I. Liquid Chromatographic/Ultraviolet Determination Of Clorsulon Residues In Kidney Tissues Of Cattle." Journal of AOAC INTERNATIONAL 75, no. 5 (1992): 937–41. http://dx.doi.org/10.1093/jaoac/75.5.937.

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28

Richter, David, Joachim Richter, Beate Grüner, Kathrin Kranz, Juliane Franz, and Peter Kern. "In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis." Parasitology Research 112, no. 4 (2013): 1655–60. http://dx.doi.org/10.1007/s00436-013-3321-7.

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Meaney, M., J. Allister, B. McKinstry, et al. "Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke." Parasitology Research 99, no. 5 (2006): 609–21. http://dx.doi.org/10.1007/s00436-006-0222-z.

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Meaney, M., J. Allister, B. McKinstry, et al. "Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke." Parasitology Research 100, no. 5 (2006): 1091–104. http://dx.doi.org/10.1007/s00436-006-0378-6.

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MARTIN, R. J., A. P. ROBERTSON, and H. BJORN. "Target sites of anthelmintics." Parasitology 114, no. 7 (1997): 111–24. http://dx.doi.org/10.1017/s0031182097001029.

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This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamate-gated chloride channels found only in invertebrates; (3) piperazine, which acts as an agonist at GABA gated chloride channels on nematode muscle; (4) praziquantel, which increases the permeability of trematode tegument to calcium and results in contraction of the parasite muscle; (5) the benzimidazoles, like thiabendazole, which bind selectively to parasite

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ROLFE, PF, and JC BORAY. "Comparative efficacy of moxidectin, an ivermectin/clorsulon combination and closantel against immature paramphistomes in cattle." Australian Veterinary Journal 70, no. 7 (2008): 265–66. http://dx.doi.org/10.1111/j.1751-0813.1993.tb08047.x.

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Schenck, Frank J., Roberta Wagner, and William Bargo. "Determination of Clorsulon Residues in Milk Using a Solid-Phase Extraction Cleanup and Liquid Chromatographic Determination." Journal of Liquid Chromatography 16, no. 2 (1993): 513–20. http://dx.doi.org/10.1080/10826079308020928.

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Martínez-Valladares, M., C. Cordero-Pérez, and F. A. Rojo-Vázquez. "Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon." Experimental Parasitology 136 (January 2014): 59–62. http://dx.doi.org/10.1016/j.exppara.2013.10.010.

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Jedziniak, Piotr, Małgorzata Olejnik, Jolanta G. Rola, and Teresa Szprengier-Juszkiewicz. "Anthelmintic residues in goat and sheep dairy products." Bulletin of the Veterinary Institute in Pulawy 59, no. 4 (2015): 515–18. http://dx.doi.org/10.1515/bvip-2015-0077.

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AbstractA multiresidue method (LC-MS/MS) for determination of wide range of anthelmintics was developed. The method covered benzimidazoles: albendazole (and metabolites), cambendazole, fenbendazol (and metabolites), flubendazole (and metabolites), mebendazole (and metabolites), oxibendazole, thiabendazole (and metabolites), triclabendazole (and metabolites); macrocyclic lactones: abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin; salicylanilides: closantel, ioxynil, nitroxynil, oxyclosamide, niclosamide, rafoxanid and others: clorsulon, derquantel, imidocarb, monepantel (a

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Vanda, Henni, Farida Athaillah, Wahyu Sari, Frengki Frengki, Nurliana Nurliana, and Muhammad Hambal. "<b>Potency of anti-trematode in inhibiting cathepsin-2L and cathepsin-5L of <i>Fasciola gigantica</i> using homology, docking, and molecular dynamics</b>." Open Veterinary Journal 14, no. 11 (2024): 2754. https://doi.org/10.5455/ovj.2024.v14.i11.4.

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<b>Background: </b> Cathepsin-L (FhCL) is a group of enzymes that most flukes express and secreted significantly in parasite-host interactions. Researches are focusing on antigens released by Fasciola gigantica as one of the keys for understanding immunologic pathway in parasite infection and targets for anthelmintics. Efforts to suppress FhCL function through vaccination or therapy using anthelmintic drugs are key factors in controlling field level trematode infections. A molecular docking method can be used to observe the interaction between FhCL and some anthelmintic drugs to be

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Mohamed Ali, Mahmoud. "Development and Validation for HPLC Method of Assay of Lvermectin and Clorsulon in Combined Pharmaceutical Dosage Form." International Journal of Homeopathy & Natural Medicines 3, no. 6 (2017): 45. http://dx.doi.org/10.11648/j.ijhnm.20170306.11.

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38

Wehner, Teresa A., James S. Wood, Robert Walker, George V. Downing, and William J. A. Vandenheuvel. "Confirmation of clorsulon residues in cattle kidney by capillary gas chromatography—negative-ion chemical-ionization mass spectrometry." Journal of Chromatography A 399 (January 1987): 251–58. http://dx.doi.org/10.1016/s0021-9673(00)96127-2.

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Meaney, M., S. Haughey, G. P. Brennan, and I. Fairweather. "Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica." Parasitology Research 95, no. 3 (2005): 201–12. http://dx.doi.org/10.1007/s00436-004-1272-8.

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40

Saad, Ahmed S., Nahla S. Ismail, Marwa Soliman, and Hala E. Zaazaa. "Validated Stability-Indicating RP-HPLC Method for Simultaneous Determination of Clorsulon and Ivermectin Employing Plackett-Burman Experimental Design for Robustness Testing." Journal of AOAC INTERNATIONAL 99, no. 2 (2016): 571–78. http://dx.doi.org/10.5740/jaoacint.15-0128.

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Abstract A sensitive and highly selective stability-indicating gradient HPLC method was developed and validated for simultaneous determination of clorsulon (CLO) and ivermectin (IVM) in the presence of their degradation products. The drugs were subjected to different stress conditions, including acid and alkaline hydrolysis, oxidative, thermal, and photolytic forced degradation. The robustness of the proposed method was assessed using the Plackett-Burman experimental design, the factors affecting system performance were defined, and nonsignificant intervals for the significant factors were det

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Guillon, A., N. Noyon, C. Gogot, S. Robert, A. Bruchet, and M. Esperanza. "Study on veterinary and human antibiotics in raw and treated water from a French basin." Water Supply 15, no. 6 (2015): 1275–84. http://dx.doi.org/10.2166/ws.2015.094.

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The aims of this work are to evaluate the presence of antibiotics in surface waters in a French water basin, where the presence of livestock is relatively important, and to understand the behaviour of antibiotics in drinking water treatment plants (DWTPs). Two sampling sites were chosen because of their livestock density and the presence of DWTPs in areas where urban activities are different. A large range of veterinary and human antibiotics were analysed in raw and treated water from the French Seine-Normandy Basin, based on the development of two analytical methodologies using solid-phase ex

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Liu, Qinpeng, Yizhen Yan, Yanyang Wu, Xiangyang Zhang, and Xinggui Zhou. "Systematic thermodynamic study of clorsulon dissolved in ten organic solvents: Mechanism evaluation by modeling and molecular dynamic simulation." Journal of Molecular Liquids 341 (November 2021): 117217. http://dx.doi.org/10.1016/j.molliq.2021.117217.

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Lankas, G. R., and C. P. Peter. "Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity." Food and Chemical Toxicology 30, no. 4 (1992): 297–306. http://dx.doi.org/10.1016/0278-6915(92)90007-8.

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markus, john, and joseph sherma. "Method II. Gas Chromatographic/Mass Spectrometric Confirmatory Method for Identification of Clorsulon Residues in Kidney Tissues of Cattle." Journal of AOAC INTERNATIONAL 75, no. 5 (1992): 942–46. http://dx.doi.org/10.1093/jaoac/75.5.942.

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Ibarra-Velarde, Froylán, Yolanda Vera-Montenegro, Ignacio Olave-Leiva, Antonio Figueroa-Castillo, Irene Cruz Mendoza, and JoaquÍn Ambía-Medina. "Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle." Pharmacology & Pharmacy 13, no. 11 (2022): 447–56. http://dx.doi.org/10.4236/pp.2022.1311033.

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Rickard, Lora G., Gary L. Zimmerman, Eric P. Hoberg, Janell K. Bishop, and Richard J. Pettitt. "Influence of ivermectin and clorsulon treatment on productivity of a cow-calf herd on the southern Oregon coast." Veterinary Parasitology 41, no. 1-2 (1992): 45–55. http://dx.doi.org/10.1016/0304-4017(92)90007-v.

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Meaney, M., S. Haughey, G. P. Brennan, and I. Fairweather. "A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica." Parasitology Research 95, no. 2 (2004): 117–28. http://dx.doi.org/10.1007/s00436-004-1259-5.

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Meaney, M., S. Haughey, G. P. Brennan, and I. Fairweather. "A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica." Parasitology Research 96, no. 3 (2005): 189–98. http://dx.doi.org/10.1007/s00436-005-1382-y.

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Ico-Gómez, Rodrigo, Roberto González-Garduño, Diego Ortiz-Pérez, et al. "Assessment of anthelmintic effectiveness to control Fasciola hepatica and paramphistome mixed infection in cattle in the humid tropics of Mexico." Parasitology 148, no. 12 (2021): 1458–66. http://dx.doi.org/10.1017/s0031182021001153.

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AbstractThe objective of this study was to evaluate the effectiveness of the main anthelmintics used for the control of trematodes in cattle in an endemic area in the humid Mexican tropics. A diagnostic study was carried out in nine cattle farms to determine the prevalence of flukes through faecal examination. Only three farms with more than 20 cows positive to trematodes were chosen to determine the effectiveness of commercial anthelmintics (triclabendazole, TCBZ; ivermectin + closantel, (IVM + CLOS); IVM + clorsulon, (CLORS); nitroxynil, NITROX). The prevalence of Fasciola hepatica was 27.1%

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Yunizeta, Refi, and Tetty Barunawati Siagian. "Pemeriksaan Kecacingan Secara Kualitatif pada Sapi Perah Friesian Holstein di KPGS Cikajang Garut." Jurnal Agroekoteknologi dan Agribisnis 5, no. 1 (2021): 1–11. http://dx.doi.org/10.51852/jaa.v5i1.472.

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Infeksi kecacingan (helminthiasis) pada sapi perah masih kurang mendapat perhatian dari para peternak dibandingkan penyakit lain. Helminthiasis menimbulkan kerugian berupa penurunan berat badan dan produksi susu. Penelitian ini dilakukan secara kualitatif dengan metode natif dan metode pengapungan (flotasi sederhana). Tujuan dari penelitian ini adalah untuk menguraikan informasi mengenai pemeriksaan kecacingan secara kualitatif pada sapi perah (Friesian holstein) dari beberapa kelompok peternak di KPGS Cikajang Garut. Sampel yang digunakan yaitu feses sapi perah yang diambil dari beberapa kelo

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