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Journal articles on the topic 'Clostridiose'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Valgaeren, B., E. Goossens, S. Verherstraeten, et al. "Gastro-intestinale Clostridium perfringens-infecties: een blijvend gevaar in de Belgische rundveehouderij." Vlaams Diergeneeskundig Tijdschrift 85, no. 1 (2016): 41–49. http://dx.doi.org/10.21825/vdt.v85i1.16407.

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De intensivering van de moderne landbouw wordt geassocieerd met een toename van Clostridium perfringens-gerelateerde, gastro-intestinale problemen bij intensief gevoede runderen, zoals “hemorrhagic bowel disease” bij hoogproductief melkvee en enterotoxemie bij kalveren. Waar de pathogenese van hemorrhagic bowel disease nog grotendeels ongekend is, werden er de laatste jaren nieuwe inzichten in de pathogenese van enterotoxemie bekomen die een belangrijke repercussie op de aanpak van deze ziekte onder praktijkomstandigheden hebben. Ook andere clostridiumgeassocieerde maagdarminfecties, zoals “ov

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2

Levkivska, N. D., D. M. Levkivsky, and B. V. Gutyj. "Epizootic features of the manifestation of clostridiosis and means of specific prophylaxis of animals in Ltd n.a. Volovikova Hoshchansk districk, Rivne region." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 94 (2019): 127–31. http://dx.doi.org/10.32718/nvlvet9423.

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According to the results of experimental and practical analysis it was determined that clostridia has an optional type of parasitism. Pathogens of clostridiosis can be stored in an abiotic environment. Under certain conditions, they multiply in soil, while reducing their virulent properties and restoring them in the process of passage through the body of susceptible animals (bones), while maintaining high virulent properties. It has been established that the epizootic process in clostridiosis is a functionally parasitic system in which the parasite populations and susceptible animals (host) in

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3

Ortiz, Diego, and Luis Carlos Villamil. "Bacterias anaerobias del suelo responsables de la muerte súbita bovina en sabanas tropicales: investigaciones realizadas en Colombia." Corpoica Ciencia y Tecnología Agropecuaria 9, no. 1 (2008): 102. http://dx.doi.org/10.21930/rcta.vol9_num1_art:110.

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<p>El estudio de las clostridiosis en Colombia debe ser una prioridad para nuestras autoridades sanitarias debido al impacto sanitario que causan estas bacterias en la salud animal. Así mismo, la agudeza de los signos y síntomas clínicos de estas patologías, y el hecho que afectan animales en buenas condiciones de carne, hacen que tengan fuerte impacto económico. Se presenta una revisión de las principales investigaciones realizadas sobre clostridiosis en los últimos años, algunas publicadas en literatura científica y otras en literatura gris. Se hace énfasis en la muerte súbita bovina,

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4

Quevedo, Pedro S., Silvia R. L. Ladeira, Mauro P. Soares, et al. "Tétano em bovinos no sul do Rio Grande do Sul: estudo de 24 surtos." Pesquisa Veterinária Brasileira 31, no. 12 (2011): 1066–70. http://dx.doi.org/10.1590/s0100-736x2011001200005.

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São descritos vinte e quatro surtos de tétano ocorridos no ano 2009 em bovinos de corte em propriedades situadas na região de influência do Laboratório Regional de Diagnóstico (LRD), sul do Rio Grande de Sul. Todos os rebanhos foram submetidos a procedimentos de vacinação e/ou aplicação de anti-helmíntico entre 8 e 25 dias antes do aparecimento dos primeiros sinais clínicos. O tempo de evolução variou de 12 horas até quatro dias. Os sinais clínicos observados foram: prolapso da terceira pálpebra, andar rígido, dificuldade de flexão dos membros e permanência em decúbito lateral com os membros e

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5

Iesina, E. V., N. M. Tishkina, and B. V. Gutyj. "Pathoanatomical diagnosis, treatment and preventive measures at pigs gastroenterocolitis." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 83 (2018): 429–34. http://dx.doi.org/10.15421/nvlvet8384.

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The reasons of the occurrence of gastroenterocolitis of pigs, their pathomorphological manifestations are being discussed, the schemes of treatment and prophylaxis are offered. The most common factor-related infections in pig breeding are colibacillosis, dysentery and ileitis (proliferative enteropathy). Colibacteriosis occurs from birth to 50–60-day age, and dysentery with ileitis - from 2 to 5–6 months. It was established that the development of gastroenterocolitis is associated with a violation of the balance of the microflora and the reproduction of pathogenic strains of microorganisms, wh

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6

Pulotov, F. Kh, and D. A. Devrishov. "Sheep clostridioses and their control." "Veterinary Medicine" Journal 22, no. 05 (2019): 27–30. http://dx.doi.org/10.30896/0042-4846.2019.22.5.28-31.

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7

Bezborodova, N. A. "MODERN APPROACH TO THE PROBLEM OF CLOSTRIDIOSIS IN ANIMAL HUSBANDRY: SAMPLING, LABORATORY DIAGNOSTICS, PREVENTION (OVERVIEW)." Problems of Veterinary Sanitation, Hygiene and Ecology 1, no. 3 (2020): 392–402. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202003016.

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The material presented in the article is a review of the literature data of foreign and domestic scientists over the last five years, including modern approaches to the problem of dangerous clostridiosis of farm animals. The terms of classical diagnostics and modern molecular genetic methods, their capabilities, new data on phenotypic criteria and results of phylogenetic analysis of spore-forming bacilli are highlighted. The main bacterial pathogens of clostridiosis in farm animals, pathogenicity factors, and their toxins are described. Methods of sampling, rules for storage and shipment of an

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8

Kashkovskaya, L. M., and V. A. Orobets. "Effective broiler therapy for clostridiosis." "Veterinary medicine" Journal 23, no. 08 (2020): 16–19. http://dx.doi.org/10.30896/0042-4846.2020.23.8.16-19.

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9

Stähle, D., T. Vogel, H. H. Wolters, et al. "Screening for clostridiae and treatment of clostridiae contamination to prevent fatal infections after liver transplantation." Transplantation Proceedings 34, no. 6 (2002): 2292–93. http://dx.doi.org/10.1016/s0041-1345(02)03240-2.

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10

Apostolov, Ross, Steven Nicolaides, and Abhinav Vasudevan. "Megacolon Complicating Ulcerative Colitis and Clostridiodes Infection." American Journal of the Medical Sciences 360, no. 4 (2020): e1-e2. http://dx.doi.org/10.1016/j.amjms.2020.04.040.

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11

Baptista, Anderson Lopes, Amanda Lima Rezende, Pedro de Almeida Fonseca, et al. "Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil." Journal of Infection in Developing Countries 11, no. 10 (2017): 791–99. http://dx.doi.org/10.3855/jidc.9296.

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Introduction: A feedlot is an intensive farming system for finishing livestock. Bovine respiratory disease (BRD) is a cause of morbidity and mortality in beef cattle, especially in feedlots. Methodology: This study investigated the morbidity and mortality of BRD in a beef cattle feedlot in southeastern Brazil using: clinical diagnoses, therapy, morbidity, and mortality. Pulmonary fragments were collected from five steers, on feed from 3-32 days, with lesions of pneumonia for identification of BRD infectious agents PCR. Results: 188,862 steers were on feed and morbidity was 7.05% (1

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12

Dickman, Jeanne A., Zeinab I. El Boghdadly, Misty Lamprecht, Samantha M. Jaglowski, Lisa Hines, and Christina Liscynesky. "Room Contamination by Patients Colonized with Clostridiodes Difficile." American Journal of Infection Control 48, no. 8 (2020): S7. http://dx.doi.org/10.1016/j.ajic.2020.07.017.

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13

Kashkovskaya, L. M., V. A. Orobets, A. Ch Shantyz, and I. S. Koba. "A method for combating clostridiosis in broilers and piglets." Agrarian science, no. 4S (May 19, 2021): 66–70. http://dx.doi.org/10.32634/0869-8155-2021-347-4-66-70.

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14

Lobato, Francisco Carlos Faria, Ronnie Antunes de Assis, Gláucia Mansur Balsamão, Vera Lúcia Viegas de Abreu, Ricardo Aurélio Pinto do Nascimento, and Ronaldo Dias Neves. "Eficácia de vacinas comerciais contra clostridioses frente ao desafio com Clostridium sordellii." Ciência Rural 34, no. 2 (2004): 439–42. http://dx.doi.org/10.1590/s0103-84782004000200016.

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Determinou-se a eficácia de doze vacinas contra clostridioses comercializadas no Brasil que contêm em sua composição Clostridium sordellii, pelo método de desafio em cobaias imunizadas. Como referência dos testes, empregou-se uma bacterina monovalente padrão. Duas vacinas (16,6%), codificadas como T6 e T8, apresentaram resultado igual à bacterina padrão, protegendo todos os animais desafiados. Uma vacina (8,3%), codificada como T10, não atendeu aos requisitos mínimos exigidos no primeiro teste, mas após o reteste foi considerada eficiente. As demais vacinas (75%), codificadas como T1, T2, T3,

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15

Pimenov, N., and Y. Kolesnikova. "COMPARATIVE CHARACTERISTIC OF THE CAUSATIVE AGENTS OF CLOSTRIDIOSIS IN CATTLE." Russian Journal of Agricultural and Socio-Economic Sciences 83, no. 11 (2018): 402–6. http://dx.doi.org/10.18551/rjoas.2018-11.48.

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16

Stegniy, B. T., N. V. Berezhna, O. V. Maiboroda, D. V. Muzyka, and O. M. Rula. "Distribution of poultry clostridiosis in Ukraine from 2013 to 2017." Bulletin "Veterinary biotechnology" 32, no. 1 (2018): 425–29. http://dx.doi.org/10.31073/vet_biotech32(1)-56.

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17

Shantyz, A. H., I. S. Koba, L. A. Hahov, and L. M. Kashkovskaya. "Therapeutic efficacy of antibacterial preparation Nosiheptide 1% in clostridiosis of piglets." Veterinaria i kormlenie, no. 7 (December 2019): 8–10. http://dx.doi.org/10.30917/att-vk-1814-9588-2019-7-2.

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18

Cotter, Jillian M., Jacob Thomas, Meghan Birkholz, et al. "Impact of Multiplex Testing on the Identification of Pediatric Clostridiodes Difficile." Journal of Pediatrics 218 (March 2020): 157–65. http://dx.doi.org/10.1016/j.jpeds.2019.11.036.

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19

Espiritu, Katrina, Michael Vernon, Donna Schora, Lance Peterson, and Kamaljit Singh. "972. Asymptomatic Carriage of Clostridiodes difficile and Risk of Subsequent Infection." Open Forum Infectious Diseases 5, suppl_1 (2018): S38. http://dx.doi.org/10.1093/ofid/ofy209.088.

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Abstract Background C. difficile is one of the most common healthcare-associated infections in the United States. Studies of patients with asymptomatic carriage of toxigenic C. difficile have reported conflicting results on the risk of subsequent C. difficile infection (CDI). Older studies suggest that the risk was low and colonization may be protective. Subsequent studies indicate that asymptomatic carriers have a 6-fold greater risk of developing CDI. The aims of our study were to assess the burden of asymptomatic C. difficile carriage and risk of subsequent CDI. Methods Adult inpatients at

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20

Yassin, Mohamed, Curtis Donskey, Ricardo Arbulu, Heather Dixon, and Kenneth Smith. "779. Clostridiodes difficile: Is it time for surveillance! Cost-benefit analysis." Open Forum Infectious Diseases 7, Supplement_1 (2020): S434. http://dx.doi.org/10.1093/ofid/ofaa439.969.

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Abstract Background Clostridiodes difficile infection (CDI) has substantial morbidity, mortality and expense. Hospital surveillance to detect CD carriers could affect antibiotic use and determination of community-associated vs hospital-associated CDI. Methods A decision tree examined the cost-effectiveness of hospital CD surveillance compared to current practice (testing as indicated). Costs for CD testing, community-associated CDI and hospital-associated CDI came from US databases. CD carrier and infection probabilities came from literature and local data. Analyses examined potential benefits

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21

Parmar, Deepika, Rebecca Dang, Margot Miranda-Katz, Amy Alabaster, and Tara L. Greenhow. "Risk Factors for Recurrent Community-associated Clostridiodes Difficile Infection in Children." Pediatric Infectious Disease Journal 38, no. 11 (2019): 1073–78. http://dx.doi.org/10.1097/inf.0000000000002439.

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22

Kramer, Yu N., and N. V. Pimenov. "Comparative evaluation of antigenic activity of means of immune prevention of anaerobic enterotoxemia of calves." Veterinariya, Zootekhniya i Biotekhnologiya 1, no. 4 (2021): 23–27. http://dx.doi.org/10.36871/vet.zoo.bio.202104003.

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The study of the antigenic activity of vaccines used against anaerobic enterotoxemia of calves was carried out. The level of antibodies during immunization with the vaccines: «Polyvalent toxoid Clostridium perfringens against anaerobic enterotoxemia of calves» and the associated vaccine against clostridiosis «Klostbovak-8» – was comparable. Credits to all types of the pathogen was protective in the application of the toxoid. At 40–50 days of age, the level of antibodies was significantly higher when using polyvalent toxoid. No antibodies were detected in the control group.

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23

Lobato, F. C. F., L. D. Dias, F. M. Salvarani, N. É. Martins, R. A. P. do Nascimento, and R. A. de Assis. "AVALIAÇÃO DA POTÊNCIA DE VACINAS CONTRA CLOSTRIDIUM SEPTICUM COMERCIALIZADAS NO BRASIL." Arquivos do Instituto Biológico 75, no. 2 (2008): 225–28. http://dx.doi.org/10.1590/1808-1657v75p2252008.

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RESUMO Clostridium septicum, um organismo ubiquitário, é o principal patógeno responsável pelo quadro de edema maligno. Devido à ação citotóxica da toxina alfa as infecções geralmente são fatais. Para o controle da doença é utilizada a vacinação com toxóide alfa. Neste trabalho, avaliouse a eficiência de 12 vacinas comerciais contra clostridioses, que continham em sua composição C. septicum, através da soroneutralização em camundongos com soros de coelhos e bovinos vacinados. As vacinas codificadas como T1, T2, T4, T10 e T11 apresentaram títulos de antitoxina alfa superiores ao nível mínimo ex

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24

Lakkasani, Saraswathi, Kok Hoe Chan, and Hamid S. Shaaban. "Clostridiodes difficile in COVID-19 Patients, Detroit, Michigan, USA, March–April 2020." Emerging Infectious Diseases 26, no. 9 (2020): 2299–300. http://dx.doi.org/10.3201/eid2609.202505.

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25

Nomlomo, E., and T. Nana. "The impact of diagnostic methods on the diagnosis of Clostridiodes difficile infection." South African Medical Journal 110, no. 2 (2020): 135. http://dx.doi.org/10.7196/samj.2020.v110i2.13684.

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26

Kilakkathi, Sindhu, Dale Tager, Michael H. Woodworth, Colleen Kraft, and Tanvi A. Dhere. "Mo1948 OUTCOMES OF INPATIENT FECAL TRANSPLANT ADMINISTRATION FOR CLOSTRIDIODES DIFFICILE INFECTION (CDI)." Gastroenterology 158, no. 6 (2020): S—989. http://dx.doi.org/10.1016/s0016-5085(20)33145-0.

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27

Sunkesula, Venkata, and Sirisha Kundrapu. "S3188 Risk of Acquiring Clostridiodes difficile Infection in IBD Patients With Anemia." American Journal of Gastroenterology 115, no. 1 (2020): S1674. http://dx.doi.org/10.14309/01.ajg.0000714800.10680.d6.

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28

Rock, Clare, and Lisa L. Maragakis. "Diagnostic Stewardship for Clostridiodes difficile Testing: From Laxatives to Diarrhea and Beyond." Clinical Infectious Diseases 71, no. 6 (2019): 1479–80. http://dx.doi.org/10.1093/cid/ciz982.

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29

Murillo, Tatiana, Gabriel Ramírez-Vargas, Thomas Riedel, et al. "Two Groups of Cocirculating, Epidemic Clostridiodes difficile Strains Microdiversify through Different Mechanisms." Genome Biology and Evolution 10, no. 3 (2018): 982–98. http://dx.doi.org/10.1093/gbe/evy059.

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30

Hain-Saunders, N., A. Harvey, and T. Riley. "Wild horses and horse manure as reservoirs for Clostridiodes difficile in Australia." International Journal of Infectious Diseases 101 (December 2020): 400. http://dx.doi.org/10.1016/j.ijid.2020.09.1048.

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31

Hain-Saunders, N., A. Harvey, and T. Riley. "Wild horses and horse manure as reservoirs for Clostridiodes difficile in Australia." International Journal of Infectious Diseases 101 (December 2020): 405. http://dx.doi.org/10.1016/j.ijid.2020.09.1063.

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32

Dolan, Russell D., Marwan S. Abougergi, and Allison R. Schulman. "Morbid Obesity Increases 30-Day Readmission and Morbidity in Clostridiodes difficile Infection." Obesity Surgery 31, no. 5 (2021): 2168–73. http://dx.doi.org/10.1007/s11695-021-05245-9.

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33

Marty, D. G. "Description de 23 clostridies cellulolytiques ou non cellulolytiques isolées du milieu marin." Annales de l'Institut Pasteur / Microbiologie 137, no. 1 (1986): 33–43. http://dx.doi.org/10.1016/s0769-2609(86)80003-5.

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34

SVARTZ, NANNA. "Contribution à la question de la classification des clostridies iodophiles de l'intestin." Acta Medica Scandinavica 71, no. 1 (2009): 1–9. http://dx.doi.org/10.1111/j.0954-6820.1929.tb14088.x.

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35

Morillas, Jose A., Ryan Miller, Kyle D. Brizendine, and Thomas G. Fraser. "2379. It’s Getting Complicated: Outcomes of Clostridiodes difficile PCR Positive/Toxin-Negative Patients." Open Forum Infectious Diseases 6, Supplement_2 (2019): S820—S821. http://dx.doi.org/10.1093/ofid/ofz360.2057.

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Abstract Background The addition of toxin enzyme immunoassay to molecular tests creates challenges in the diagnosis and management of Clostridiodes difficile infection (CDI). In limited samples of PCR+/ toxin- patients, CDI-attributable complications are thought to be rare, even nonexistent. We aimed to characterize outcomes of a large PCR+/ toxin− cohort within 60 days of initial testing date. Methods We conducted a retrospective cohort study on all PCR+/toxin- adult inpatients from June–December 2018. Patients were placed into 3 groups to analyze outcomes: (1) complete treatment (guideline c

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36

Song, Jiyoun, Philip Zachariah, Bevin Cohen, Jianfang Liu, and Elaine Larson. "2393. Dimensions of Cumulative Antibiotic Exposure and Risk of Hospital Onset Clostridiodes Difficile." Open Forum Infectious Diseases 6, Supplement_2 (2019): S826. http://dx.doi.org/10.1093/ofid/ofz360.2071.

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Abstract Background The association between antibiotic exposure (AE) and healthcare-associated Clostridiodes difficile infection (HA-CDI) has been mostly quantified using cumulative AE as the predictor. However, patients receive similar durations of antibiotics in a variety of ways. We examine the relationship between HA-CDI and other dimensions of AE. Methods Retrospective cohort study was conducted with pediatric and adult inpatients at three New York City hospitals between 2011- 2016 who were prescribed at least one dose of antibiotic, excluding those used to treat CDI. Patient data were co

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37

Solana, María José, Amaya Bustinza, Jorge López, and Jesús López-Herce. "Clostridiodes difficile associated disease risk and proton pump inhibitors in critically ill children." Enfermedades infecciosas y microbiologia clinica (English ed.) 39, no. 3 (2021): 160–61. http://dx.doi.org/10.1016/j.eimce.2020.06.010.

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38

Sánchez-Pellicer, Pedro, Vicente Navarro-López, Ruth González-Tamayo, et al. "Descriptive Study of Gut Microbiota in Infected and Colonized Subjects by Clostridiodes difficile." Microorganisms 9, no. 8 (2021): 1727. http://dx.doi.org/10.3390/microorganisms9081727.

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Clostridiodes difficile can lead to a range of situations from the absence of symptoms (colonization) to severe diarrhea (infection). Disruption of gut microbiota provides an ideal environment for infection to occur. Comparison of gut microbiota of infected and colonized subjects could provide relevant information on susceptible groups or protectors to the development of infection, since the presence of certain genera could be related to the inhibition of transition from a state of colonization to infection. Through high-throughput sequencing of 16S rDNA gene, we performed alpha and beta diver

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Canales, Jailene, Alison Weiss, and Senu Apewokin. "4530 Elucidating the Influence of Chemotherapy (melphalan) and /or C. difficile toxin B Exposure on Beta-catenin Protein Expression in Caco-2 Monolayers." Journal of Clinical and Translational Science 4, s1 (2020): 95. http://dx.doi.org/10.1017/cts.2020.297.

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OBJECTIVES/GOALS: We previously reported that genetic polymorphisms in the beta-catenin gene (CTNNB) are associated with the development of Clostridiodes difficile colitis during autologous stem cell transplantation (https://www-ncbi-nlm-nih-gov.proxy.libraries.uc.edu/pubmed/29594489). To biological validate these findings, we sought to evaluate the development of chemotherapy-associated Clostridiodes difficile infections by assessing the effect of C.difficile toxin B (TcdB) and of using melphalan in beta-catenin protein expression in Caco2 cells. METHODS/STUDY POPULATION: To determine the eff

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40

Fecskeová, Lívia, Peter Pristaš, and Peter Javorský. "Cloning and characterization of cobA, one of vitamin B12 biosynthesis pathway genes from Selenomonas ruminantium." Nova Biotechnologica et Chimica 10, no. 2 (2021): 131–35. http://dx.doi.org/10.36547/nbc.1122.

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Bacterial biosynthesis of vitamin B12 can occur via either aerobic or anaerobic route. While the aerobic pathway has been fully elucidated and understood, less is known about the anaerobic pathway. Selenomonas ruminantium is thought to be the main producer of this vitamin in rumen environment and must use the anaerobic pathway. In our work we found one of the genes of vitamin B12 biosynthetic pathway of S. ruminantium, encoding for the cobalamin adenosyltransferase, enzyme taking part at the last steps of the synthesis process. Deduced amino acid sequence showed the highest similarity to cobal

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41

Lueders, Imke, Carsten Ludwig, Johanna Kasberg, et al. "Unusual Outbreak of Fatal Clostridiosis in a Group of Captive Brown Pelicans (Pelecanus occidentalis)." Journal of Avian Medicine and Surgery 31, no. 4 (2017): 359–63. http://dx.doi.org/10.1647/2016-237.

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42

Tariq, Raseen, Muhammad Waqas Tahir, Faisal Kamal, Ahmad Khan, Darrell S. Pardi, and Sahil Khanna. "Mo1942 OUTCOMES OF CLOSTRIDIODES DIFFICILE INFECTION IN SURGICAL PATIENTS: RESULTS FROM NATIONAL INPATIENT SAMPLE." Gastroenterology 158, no. 6 (2020): S—986—S—987. http://dx.doi.org/10.1016/s0016-5085(20)33139-5.

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43

Cairns, Chantelle M., Henk van Faassen, Frank St. Michael, et al. "Development and Characterization of Mouse Monoclonal Antibodies Specific for Clostridiodes (Clostridium) difficile Lipoteichoic Acid." ACS Chemical Biology 15, no. 4 (2020): 1050–58. http://dx.doi.org/10.1021/acschembio.0c00066.

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44

Kitamoto, Hiroko, Peter Higgins, Vincent Young, and Nobuhiko Kamada. "P163 DYSREGULATED MICROBIAL METABOLISM IN ULCERATIVE COLITIS INCREASES THE RISK OF CLOSTRIDIODES DIFFICILE INFECTION." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S40. http://dx.doi.org/10.1093/ibd/zaa010.102.

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Abstract Clostridioides difficile infection (CDI) is recognized as a major clinical complication in patients with ulcerative colitis (UC). However, the mechanism associated with increased susceptibility to C. difficile in UC patients remains poorly understood. Given the evidence that the gut microbiota plays a critical role in the prevention of CDI and that gut microbiota is perturbed in UC patients, we hypothesized that UC-associated gut dysbiosis contributes to the increased susceptibility of patients to CDI. To address this hypothesis, we employed the human microbiota-associated (HMA) mouse

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45

White, Nicole C., Rafael Mendo-Lopez, Konstantinos Papamichael, et al. "Laxative Use Does Not Preclude Diagnosis or Reduce Disease Severity in Clostridiodes difficile Infection." Clinical Infectious Diseases 71, no. 6 (2019): 1472–78. http://dx.doi.org/10.1093/cid/ciz978.

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Abstract Background To optimize utility of laboratory testing for Clostridiodes difficile infection (CDI), the 2017 Infectious Diseases Society of America–Society for Healthcare Epidemiology of America (IDSA-SHEA) clinical practice guidelines recommend excluding patients from stool testing for C. difficile if they have received laxatives within the preceding 48 hours. Sparse data support this recommendation. Methods Patients with new-onset diarrhea (≥3 bowel movements in any 24-hour period in the 48 hours before stool collection) and a positive stool C. difficile nucleic acid amplification tes

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Hoegg, Cindy L., Katie L. Williams, Eric Shelov, et al. "2346. Cost Savings Associated with Implementation of Clinical Decision Support for Clostridiodes difficile Testing." Open Forum Infectious Diseases 6, Supplement_2 (2019): S806—S807. http://dx.doi.org/10.1093/ofid/ofz360.2024.

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Abstract Background Clinical decision support for Clostridioides difficile infection (CDI) diagnostics reduces inappropriate testing, leading to decreased need for isolation and antibiotic use. Our institution utilized manual discontinuation by laboratory staff of CDI testing for inappropriate specimens, including formed stool and age < 1 year. We aimed to assess the financial impact of instituting a CDI best practice alert at a quaternary care children’s hospital. Methods A multidisciplinary team mapped inappropriate testing criteria identified from literature review with discrete fields i

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Marra, Alexandre R., Mohammed Alzunitan, Oluchi Abosi, et al. "Modest Clostridiodes difficile infection prediction using machine learning models in a tertiary care hospital." Diagnostic Microbiology and Infectious Disease 98, no. 2 (2020): 115104. http://dx.doi.org/10.1016/j.diagmicrobio.2020.115104.

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Kitamoto, Hiroko, Peter Higgins, Vincent Young, and Nobuhiko Kamada. "P163 DYSREGULATED MICROBIAL METABOLISM IN ULCERATIVE COLITIS INCREASES THE RISK OF CLOSTRIDIODES DIFFICILE INFECTION." Gastroenterology 158, no. 3 (2020): S65. http://dx.doi.org/10.1053/j.gastro.2019.11.167.

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Gupta, Akshita, and Ashwin N. Ananthakrishnan. "Economic burden and cost-effectiveness of therapies for Clostridiodes difficile infection: a narrative review." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110186. http://dx.doi.org/10.1177/17562848211018654.

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Clostridioides difficile is the most common cause of healthcare-associated diarrhea. Disease complications as well as recurrent infections contribute significantly to morbidity and mortality. Over the past decades, there has been a rapid increase in the incidence of C. difficile infection (CDI), with a rise in the number of community-acquired cases. CDI has a profound economic impact on both the healthcare system and patients, secondary to recurrences, hospitalization, prolonged length of stay, cost of treatment, and indirect societal costs. With emergence of newer treatment options, the stand

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Balseiro, Ana, Luis J. Royo, Elena Gayo, Ramón Balsera, Olga Alarcia, and Juan F. García Marín. "Mortality Causes in Free-Ranging Eurasian Brown Bears (Ursus arctos arctos) in Spain 1998–2018." Animals 10, no. 9 (2020): 1538. http://dx.doi.org/10.3390/ani10091538.

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This work summarizes the mortality cases of twenty-five free-ranging Eurasian wild brown bears (Ursus arctos arctos) from the Cantabrian mountain range submitted for necropsy in Asturias and Castilla y León (northwestern Spain) from 1998 to 2018. Mortality cases were classified both caused by (i) “non-human intervention” or “human intervention” causes and based on (ii) “non-infectious” or “infectious” etiology. In four cases (16%) it was not possible to determine the cause of death due to the inadequate preservation of collected specimens or insufficient tissue availability. Based on “non-huma

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