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1

Turnbull, Gareth, Euan Spierits, David Russell, Jon Clarke, Frédéric Picard, and Martin Sarungi. "Clostridium septicum arthroplasty infection: beware of occult aortitis and malignancy." Scottish Medical Journal 63, no. 4 (2018): 132–39. http://dx.doi.org/10.1177/0036933018793525.

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Introduction The Clostridia species are responsible for life-threatening conditions such as tetanus, botulism and gas gangrene. Clostridium septicum is a rare cause of clinical infection, accounting for less than 1% of blood culture samples that test positive for Clostridia. However, C. septicum bacteraemia is associated with greater than 60% mortality and in over 80% of cases is associated with an underlying malignancy. Case presentation We present a review of the literature and the first case of an acute arthroplasty infection and concurrent infective aortitis caused by this organism in the
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2

Agustin, Eric T., Elena Febre, Gerald M. Brody, Audie Liametz, and Burke A. Cunha. "Clostridium septicum syndrome." Annals of Emergency Medicine 24, no. 5 (1994): 988–89. http://dx.doi.org/10.1016/s0196-0644(94)70220-9.

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3

Onuorah, Luke N., and John S. Czachor. "Clostridium septicum Triad." Infectious Diseases in Clinical Practice 27, no. 5 (2019): 288–89. http://dx.doi.org/10.1097/ipc.0000000000000750.

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4

Katyal, Anup, and Dayton Dmello. "Clostridium septicum Pneumocephalus." Neurocritical Care 24, no. 2 (2015): 264–67. http://dx.doi.org/10.1007/s12028-015-0192-z.

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5

Khurana, Aditya, Ciléin Kearns, Anna Sophia McKenney, and Ahmed M. Gabr. "Clostridium Septicum Aortitis." RadioGraphics 41, no. 5 (2021): E147—E148. http://dx.doi.org/10.1148/rg.2021210178.

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6

Assis, R. A., F. C. F. Lobato, Z. I. P. Lobato, et al. "PCR multiplex para identificação de isolados de Clostridium chauvoei e Clostridium septicum." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 60, no. 2 (2008): 294–98. http://dx.doi.org/10.1590/s0102-09352008000200003.

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Padronizou-se uma técnica de reação em cadeia da polimerase múltipla (PCR multiplex) para detecção de Clostridium chauvoei e Clostridium septicum em culturas puras. Foram utilizados pares de iniciadores para segmentos específicos dos genes que codificam a flagelina de C. chauvoei e a toxina alfa de C. septicum. Para avaliaçã o da PCR multiplex, foram testados 16 isolados clínicos de C. chauvoei e 15 isolados de C. septicum provenientes de ruminantes, quatro sementes vacinais de cada um desses agentes. Amostras de referência de ambos os microrganismos foram usadas como controle. Para avaliar a
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7

Shah, Sweta, Sowmya Nanjappa, Smitha Pabbathi, and John Greene. "Clostridium septicum Case Series." Infectious Diseases in Clinical Practice 24, no. 2 (2016): 72–75. http://dx.doi.org/10.1097/ipc.0000000000000356.

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8

Laudito, Antonio, Valerio Gai, Stefania Battista, Domenica Garabello, Giorgio Limerutti, and Mauro Rinaldi. "Clostridium Septicum Arch Aortitis." Circulation 117, no. 12 (2008): 1609. http://dx.doi.org/10.1161/circulationaha.107.713685.

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9

HIEW, C. Y., M. SILBERSTEIN, and O. F. HENNESSY. "Fatal Clostridium septicum myonecrosis." Australasian Radiology 37, no. 4 (1993): 399–400. http://dx.doi.org/10.1111/j.1440-1673.1993.tb00107.x.

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10

Chew, Simon S. B., and David Z. Lubowski. "Clostridium septicum and malignancy." ANZ Journal of Surgery 71, no. 11 (2001): 647–49. http://dx.doi.org/10.1046/j.1445-1433.2001.02231.x.

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11

Zenati, Marco A., Gianluca Bonanomi, Dean Kostov, and Robert Lee. "Fulminant Clostridium septicum Aortitis." Circulation 105, no. 15 (2002): 1871. http://dx.doi.org/10.1161/01.cir.0000016163.45584.a1.

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12

Bajpai, Vijeta, Aishwarya Govindaswamy, Sonu Kumari Agrawal, Rajesh Malhotra, and Purva Mathur. "Clostridium sordelli as a cause of gas gangrene in a trauma patient." Journal of Laboratory Physicians 11, no. 01 (2019): 094–96. http://dx.doi.org/10.4103/jlp.jlp_108_18.

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AbstractGas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is Clostridium perfringens followed by Clostridium septicum. Here, we are reporting an unusual case report of posttraumatic gas gangrene caused by Clostridium sordelli.
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13

Šulc, Daniel, Martina Vaněrková, Martin Radvan, et al. "Acute purulent pericarditis caused by Clostridium septicum." Cor et Vasa 60, no. 4 (2018): e407-e411. http://dx.doi.org/10.1016/j.crvasa.2017.02.003.

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14

Pinto, Flávia Ferreira, Ronnie Antunes de Assis, Francisco Carlos Faria Lobato, Agueda Castagna de Vargas, Ricardo Rocha Barros, and Luciana Aramuni Gonçalves. "Edema maligno em suíno." Ciência Rural 35, no. 1 (2005): 227–29. http://dx.doi.org/10.1590/s0103-84782005000100038.

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Edema maligno em suíno é uma infecção fatal da musculatura esquelética e tecido subcutâneo de ruminantes e outras espécies animais, causada principalmente por Clostridium septicum, embora possa ocorrer em associação com Clostridium chauvoei, Clostridium sordellii, Clostridium novyi tipo A e Clostridium perfringens tipo A. O diagnóstico efetivo do edema maligno deve levar em consideração, além dos dados clínicos e lesões de necropsia, os achados microscópicos, isolamento do agente, imunofluorescência direta, imunoistoquímica e PCR. Embora haja poucos relatos de edema maligno em suínos na litera
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15

Jessamy, Kegan, Fidelis O. Ojevwe, Ezinnaya Ubagharaji, et al. "Clostridium septicum: An Unusual Link to a Lower Gastrointestinal Bleed." Case Reports in Gastroenterology 10, no. 2 (2016): 489–93. http://dx.doi.org/10.1159/000448881.

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Clostridium septicum is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. Presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. We report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. While she was being treated with empiric antibiotics, her blood culture was found to be positive for C. septicum. We would like to highli
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16

Neimkin, Ronald J., and Jesse B. Jupiter. "Metastatic nontraumatic Clostridium septicum osteomyelitis." Journal of Hand Surgery 10, no. 2 (1985): 281–84. http://dx.doi.org/10.1016/s0363-5023(85)80123-4.

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17

Munshi, Imtiaz A., Sang Won Rhee, Thomas Pane, and Eric Granowitz. "Clostridium septicum mycotic aortic aneurysm." American Journal of Surgery 184, no. 1 (2002): 54–55. http://dx.doi.org/10.1016/s0002-9610(02)00883-8.

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18

King, Ashley, and D. G. D. Wight. "CLOSTRIDIUM SEPTICUM AND NEUTROPENIC ENTEROCOLITIS." Lancet 330, no. 8570 (1987): 1279. http://dx.doi.org/10.1016/s0140-6736(87)91895-2.

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19

RICCIO, JOHN A., and OSCAR R. OBERKIRCHER. "Clostridium septicum sepsis and cerebritis." Pediatric Infectious Disease Journal 7, no. 5 (1988): 342–45. http://dx.doi.org/10.1097/00006454-198805000-00011.

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20

BRATTON, SUSAN L., ELLIOT J. KRANE, JULIE R. PARK, and SANDRA BURCHETTE. "Clostridium septicum infections in children." Pediatric Infectious Disease Journal 11, no. 7 (1992): 569–75. http://dx.doi.org/10.1097/00006454-199207000-00011.

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21

Lindland, Are, and Jon Erik Slagsvold. "Binocular endogenous Clostridium septicum endophthalmitis." Acta Ophthalmologica Scandinavica 85, no. 2 (2006): 232–34. http://dx.doi.org/10.1111/j.1600-0420.2006.00771.x.

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22

Swiatek, P. J., S. D. Allen, J. A. Siders, and C. H. Lee. "DNase production by Clostridium septicum." Journal of Clinical Microbiology 25, no. 2 (1987): 437–38. http://dx.doi.org/10.1128/jcm.25.2.437-438.1987.

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23

Christina Dirks, Hans Horn, Leslie. "CNS Infection with Clostridium septicum." Scandinavian Journal of Infectious Diseases 32, no. 3 (2000): 320–22. http://dx.doi.org/10.1080/00365540050166009.

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24

María Calvo, José, Pedro Bureo, and Manuel Pérez. "Bacteriemia por Clostridium septicum paraneoplásica." Enfermedades Infecciosas y Microbiología Clínica 19, no. 4 (2001): 183. http://dx.doi.org/10.1016/s0213-005x(01)72603-1.

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25

O'Rourke, E., K. Sharrock, and M. Pelly. "Clostridium septicum: a Malign Pathogen." Journal of Infection 41, no. 3 (2000): 286–88. http://dx.doi.org/10.1053/jinf.2000.0749.

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26

Blum, K., U. Wiebking, and H. Rosenthal. "Spontane Gasbrandinfektion mit Clostridium septicum." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 182, no. 06 (2010): 529–31. http://dx.doi.org/10.1055/s-0029-1245320.

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27

Maier, Sebastian, and Hans Wahn. "Gasbrand bei Clostridium-septicum-Sepsis." Medizinische Klinik 95, no. 10 (2000): 599. http://dx.doi.org/10.1007/pl00002070.

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28

Schickner, Daniel C., Alon Yarkoni, Paul Langer, et al. "Panophthalmitis due to clostridium septicum." American Journal of Ophthalmology 137, no. 5 (2004): 942–44. http://dx.doi.org/10.1016/j.ajo.2003.10.030.

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29

Pelletier, J. Peter R., Julie A. Plumbley, Elizabeth A. Rouse, and Stephen J. Cina. "The Role of Clostridium septicum in Paraneoplastic Sepsis." Archives of Pathology & Laboratory Medicine 124, no. 3 (2000): 353–56. http://dx.doi.org/10.5858/2000-124-0353-trocsi.

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Abstract Context.—Clostridium septicum infections are rare but often associated with serious if not fatal outcomes. Clostridium septicum infection does not appear to be associated with a single specific defect in cellular or humoral immunity. It has been associated with multiple medical problems, including but not limited to leukemia, malignancy of the bowel, other solid tumors, cyclic neutropenia with enterocolitis, diabetes mellitus, and severe arteriosclerosis. Most cases of C septicum are associated with malignancy, and mortality approaches 100% if care is not rendered within 12 to 24 hour
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30

Barnes, C., J. T. Gerstle, M. H. Freedman, and M. D. Carcao. "Clostridium septicum Myonecrosis in Congenital Neutropenia." PEDIATRICS 114, no. 6 (2004): e757-e760. http://dx.doi.org/10.1542/peds.2004-0124.

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31

Simsir, S. "Clostridium septicum infection of the aorta." American Journal of Surgery 181, no. 6 (2001): 577–78. http://dx.doi.org/10.1016/s0002-9610(01)00620-1.

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32

Khalid, M., R. Lazarus, I. C. Bowler, and C. Darby. "Clostridium septicum sepsis and its implications." Case Reports 2012, sep05 2 (2012): bcr2012006167. http://dx.doi.org/10.1136/bcr-2012-006167.

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33

Forrester, Joseph D., Eugene Shkolyar, David Gregg, David A. Spain, and Thomas G. Weiser. "Nontraumatic Clostridium septicum Myonecrosis in Adults." Infectious Diseases in Clinical Practice 24, no. 6 (2016): 318–23. http://dx.doi.org/10.1097/ipc.0000000000000400.

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34

Slenker, Amy K., and Joseph A. DeSimone. "Clostridium septicum Panophthalmitis Complicated by Meningitis." Infectious Diseases in Clinical Practice 20, no. 5 (2012): 305–8. http://dx.doi.org/10.1097/ipc.0b013e31824f8a6d.

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35

KORNBLUTH, ARTHUR A., JEFFREY B. DANZIG, and LESLIE H. BERNSTEIN. "Clostridium septicum Infection and Associated Malignancy." Medicine 68, no. 1 (1989): 30–37. http://dx.doi.org/10.1097/00005792-198901000-00002.

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36

Yeong, Mee Ling, and Gordon I. Nicholson. "Clostridium septicum infection in neutropenic enterocolitis." Pathology 20, no. 2 (1988): 194–97. http://dx.doi.org/10.3109/00313028809066634.

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37

Rai, R. K., S. Londhe, S. Sinha, A. C. Campbell, and I. S. Aburiziq. "SPONTANEOUS BIFOCAL CLOSTRIDIUM SEPTICUM GAS GANGRENE." Journal of Bone and Joint Surgery. British volume 83-B, no. 1 (2001): 115–16. http://dx.doi.org/10.1302/0301-620x.83b1.0830115.

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38

PRITCHETT, JAMES W. "Spontaneous bifocal Clostridium septicum gas gangrene." Journal of Bone and Joint Surgery. British volume 83-B, no. 4 (2001): 621. http://dx.doi.org/10.1302/0301-620x.83b4.0830621.

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39

Habscheid, W., C. Bernhardt, M. Sold, et al. "Atraumatische Clostridium-septicum-Infektion bei Granulozytopenie." DMW - Deutsche Medizinische Wochenschrift 116, no. 49 (2008): 1862–66. http://dx.doi.org/10.1055/s-2008-1063830.

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40

KAWAGUCHI, K., and S. CHURCH. "Clostridium septicum arthritis in three foals." Australian Veterinary Journal 82, no. 10 (2004): 612–15. http://dx.doi.org/10.1111/j.1751-0813.2004.tb12600.x.

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41

Insler, M. S., Z. A. Karcioglu, and T. Naugle. "Clostridium septicum panophthalmitis with systemic complications." British Journal of Ophthalmology 69, no. 10 (1985): 774–77. http://dx.doi.org/10.1136/bjo.69.10.774.

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42

Crawford, Byron E., and Terese D. Racha. "Spontaneous Myonecrosis Secondary to Clostridium septicum." Laboratory Medicine 30, no. 7 (1999): 444–47. http://dx.doi.org/10.1093/labmed/30.7.444.

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43

Mizrahi, Daniel J., and Ethan J. Halpern. "Clostridium septicum aortitis and colon carcinoma." Journal of Cardiovascular Computed Tomography 10, no. 3 (2016): 258–60. http://dx.doi.org/10.1016/j.jcct.2016.01.002.

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44

Wongboonsin, Janewit, Alisa Duran, and James R. Johnson. "Infectious Pneumorachis Due to Clostridium septicum." Journal of General Internal Medicine 35, no. 7 (2020): 2197–98. http://dx.doi.org/10.1007/s11606-020-05827-w.

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45

Dylewski, J., and L. Luterman. "Septic arthritis and Clostridium septicum: a clue to colon cancer." Canadian Medical Association Journal 182, no. 13 (2010): 1446–47. http://dx.doi.org/10.1503/cmaj.091946.

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46

Lehman, Bethany, Ryan Miller, George Keller, Sandra S. Richter, and Susan J. Rehm. "1032. A Case Series of Clostridium septicum Aortitis." Open Forum Infectious Diseases 5, suppl_1 (2018): S307—S308. http://dx.doi.org/10.1093/ofid/ofy210.869.

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Abstract Background Clostridium septicum is an anaerobic, motile, spore forming, toxin-producing Gram-positive bacillus (GPB) that has been associated with colon and hematologic malignancies. Despite the low incidence of infection, it is a virulent organism leading to rapidly progressive gas gangrene. Only 51 cases of C. septicum related aortic aneurysms have been reported. 100% mortality is reported in patients without surgical intervention vs. 79% undergoing surgery. The primary aim of this study was to determine the incidence and clinical outcomes of patients treated at our institution with
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47

Dylewski, Joe, Robert Drummond, and John Rowen. "A case of Clostridium septicum spontaneous gas gangrene." CJEM 9, no. 02 (2007): 133–35. http://dx.doi.org/10.1017/s1481803500014950.

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ABSTRACT Severe skin and soft tissue infections (SSTIs) are often life-threatening emergencies that require a rapid diagnosis. Gas gangrene is one of the most fulminant types of SSTI and is usually caused by Clostridium perfringens' contamination of an open wound. Although gas gangrene is usually associated with fecally contaminated wounds, “spontaneous” cases occur and are most commonly caused by Clostridium (C.) septicum. We report a case of spontaneous gas gangrene caused by C. septicum that only became manifest while the patient was being monitored in the emergency department. We also revi
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48

Sidhu, Jasdeep Singh, Amrendra Mandal, Jeevanjot Virk, and Vijay Gayam. "Early Detection of Colon Cancer Following Incidental Finding of Clostridium septicum Bacteremia." Journal of Investigative Medicine High Impact Case Reports 7 (January 2019): 232470961983205. http://dx.doi.org/10.1177/2324709619832050.

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Clostridium septicum is a Gram-positive, anaerobic, spore-forming bacillus found in the intestine. It is linked to colon cancer and immunosuppression. Infection with C septicum may vary in manifestation and is associated with more than 60% mortality rate. In this article, we present a case of incidental isolation of C septicum in a patient who presented with fever and later on colonoscopy was found to have colon carcinoma. Bacteremia may be the unexpected initial presentation of undiagnosed colon carcinoma.
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49

Raymundo, Djeison Lutier, Saulo Petinatti Pavarini, Pedro Soares Bezerra Junior, et al. "Mionecrose aguda por Clostridium septicum em equinos." Pesquisa Veterinária Brasileira 30, no. 8 (2010): 637–40. http://dx.doi.org/10.1590/s0100-736x2010000800005.

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Descrevem-se dois casos de miosite necrosante causada por Clostridium septicum em equinos. Os dois equinos apresentavam aumento de volume no membro pélvico direito e que se estendia para a região abdominal ventral. Ao corte, essa área era formada por edema sanguinolento e bolhas de gás. Os músculos esqueléticos da região caudal da coxa apresentavam áreas vermelho-escuras, crepitantes, com edema sanguinolento e, ao corte, as áreas mais profundas da musculatura tinham aspecto seco. As principais alterações histopatológicas observadas foram tumefação, vacuolização, necrose hialina e necrose flocu
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50

Monsen, T., H. Palmgren, and C. Arnerlöv. "Aortic dissection due to Clostridium septicum infection." European Journal of Vascular and Endovascular Surgery 13, no. 5 (1997): 517–18. http://dx.doi.org/10.1016/s1078-5884(97)80183-9.

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