Academic literature on the topic 'Cluster randomised trials'

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Journal articles on the topic "Cluster randomised trials"

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Barbui, C., and A. Cipriani. "Cluster randomised trials." Epidemiology and Psychiatric Sciences 20, no. 4 (2011): 307–9. http://dx.doi.org/10.1017/s2045796011000515.

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Although randomised controlled trials are the reference methodology to assess the effects of therapeutic interventions, for interventions that naturally occur in groups of individuals random allocation of participants may be inappropriate. In these cases, the unit of random allocation may be the group or cluster, rather than the individual. Clinical trials that randomly allocate groups or clusters of individuals are called cluster randomised trials. This article briefly presents the main implications of cluster randomisation with respect to the following methodological aspects: generalisabilit
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Batistatou, Eva. "Cluster Randomised Trials." Journal of the Royal Statistical Society: Series A (Statistics in Society) 173, no. 1 (2010): 271. http://dx.doi.org/10.1111/j.1467-985x.2009.00624_4.x.

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Campbell, Michael J. "Cluster randomised trials." Medical Journal of Australia 210, no. 4 (2019): 154. http://dx.doi.org/10.5694/mja2.13001.

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Freemantle, N., J. Wood, M. K. Campbell, and J. M. Grimshaw. "Cluster randomised trials." BMJ 318, no. 7193 (1999): 1286. http://dx.doi.org/10.1136/bmj.318.7193.1286b.

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Sedgwick, P. "Cluster randomised controlled trials." BMJ 345, jul11 1 (2012): e4654-e4654. http://dx.doi.org/10.1136/bmj.e4654.

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Grayling, Michael J., James MS Wason, and Adrian P. Mander. "Group sequential designs for stepped-wedge cluster randomised trials." Clinical Trials 14, no. 5 (2017): 507–17. http://dx.doi.org/10.1177/1740774517716937.

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Background/Aims: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster randomised trials with interim analyses. In an individually randomised trial setting, group sequential methods can provide notable efficiency gains and ethical benefits. We address this by discussing how established group sequential methodology can be adapted for stepped-wedge designs. Methods: Utilising the error spending approach to group seq
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Kristunas, Caroline, Tom Morris, and Laura Gray. "Unequal cluster sizes in stepped-wedge cluster randomised trials: a systematic review." BMJ Open 7, no. 11 (2017): e017151. http://dx.doi.org/10.1136/bmjopen-2017-017151.

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ObjectivesTo investigate the extent to which cluster sizes vary in stepped-wedge cluster randomised trials (SW-CRT) and whether any variability is accounted for during the sample size calculation and analysis of these trials.SettingAny, not limited to healthcare settings.ParticipantsAny taking part in an SW-CRT published up to March 2016.Primary and secondary outcome measuresThe primary outcome is the variability in cluster sizes, measured by the coefficient of variation (CV) in cluster size. Secondary outcomes include the difference between the cluster sizes assumed during the sample size cal
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Hemming, Karla, Monica Taljaard, Gordon Forbes, Sandra M. Eldridge, and Charles Weijer. "Ethical implications of excessive cluster sizes in cluster randomised trials." BMJ Quality & Safety 27, no. 8 (2018): 664–70. http://dx.doi.org/10.1136/bmjqs-2017-007164.

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The cluster randomised trial (CRT) is commonly used in healthcare research. It is the gold-standard study design for evaluating healthcare policy interventions. A key characteristic of this design is that as more participants are included, in a fixed number of clusters, the increase in achievable power will level off. CRTs with cluster sizes that exceed the point of levelling-off will have excessive numbers of participants, even if they do not achieve nominal levels of power. Excessively large cluster sizes may have ethical implications due to exposing trial participants unnecessarily to the b
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Weijer, Charles, and Monica Taljaard. "Ottawa Statement does not impede randomised evaluation of government health programmes." Journal of Medical Ethics 46, no. 1 (2019): 31–33. http://dx.doi.org/10.1136/medethics-2019-105938.

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In this issue of JME, Watson et al call for research evaluation of government health programmes and identify ethical guidance, including the Ottawa Statement on the ethical design and conduct of cluster randomised trials, as a hindrance. While cluster randomised trials of health programmes as a whole should be evaluated by research ethics committees (RECs), Watson et al argue that the health programme per se is not within the researcher’s control or responsibility and, thus, is out of scope for ethics review. We argue that this view is wrong. The scope of research ethics review is not defined
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Chan, Claire L., Clémence Leyrat, and Sandra M. Eldridge. "Quality of reporting of pilot and feasibility cluster randomised trials: a systematic review." BMJ Open 7, no. 11 (2017): e016970. http://dx.doi.org/10.1136/bmjopen-2017-016970.

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ObjectivesTo systematically review the quality of reporting of pilot and feasibility of cluster randomised trials (CRTs). In particular, to assess (1) the number of pilot CRTs conducted between 1 January 2011 and 31 December 2014, (2) whether objectives and methods are appropriate and (3) reporting quality.MethodsWe searched PubMed (2011–2014) for CRTs with ‘pilot’ or ‘feasibility’ in the title or abstract; that were assessing some element of feasibility and showing evidence the study was in preparation for a main effectiveness/efficacy trial. Quality assessment criteria were based on the Cons
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Dissertations / Theses on the topic "Cluster randomised trials"

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Jarvis, C. "Spatial analysis of cluster randomised trials." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2018. http://researchonline.lshtm.ac.uk/4648971/.

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Cluster randomised trials (CRTs) often use geographical areas as the unit of randomisation. Despite this, explicit consideration of the location and spatial distribution of observations is rare. In many trials, the location of participants will have little importance, however in some, especially against infectious diseases, spillover effects due to participants being located close together may affect trial results. This PhD takes a multidisciplinary approach to apply and evaluate spatial analysis methods in CRTs, furthering understanding of how spatial analysis can complement traditional evalu
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Hossain, A. "Missing data in cluster randomised trials." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/4646133/.

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Missing outcomes are a commonly occurring problem in cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Handling missing data in CRTs is complicated due to the hierarchical structure of the data. Two approaches for analysing such trials are cluster-level analysis and individual level analysis. An assumption regarding missing outcomes in CRTs that is sometimes plausible is that missingness depends on baseline covariates, but conditioning on these baseline covariates, not on the outcome itself, which is known as a covariate depend
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Mollison, Jill. "Use of cluster randomised trials in implementation research." Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602063.

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Background. Implementation research is the scientific study of methods to promote the uptake of research findings in clinical practice. Cluster randomised trials are commonly adopted in implementation research, where interventions are generally targeted at health professionals or policymakers, in order to protect against contamination that would occur if individual patients were randomised. The application of cluster randomisation has important implications for design and analysis of trials evaluating implementation strategies. Case study: The Urological referral guidelines evaluation (URGE) h
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Wright, Neil D. "Choosing covariates in the analysis of cluster randomised trials." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9017.

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Covariate adjustment is common in the analysis of randomised trials, and can increase statistical power without increasing sample size. Published research on covariate adjustment, and guidance for choosing covariates, focusses on trials where individuals are randomised to treatments. In cluster randomised trials (CRTs) clusters of individuals are randomised. Valid analyses of CRTs account for the structure imposed by cluster randomisation. There is limited published research on the e ects of covariate adjustment, or guidance for choosing covariates, in analyses of CRTs. I summarise existing gu
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Martin, James Thomas. "Advancing knowledge in stepped-wedge cluster randomised controlled trials." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8034/.

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This thesis aims to extend the existing knowledge and enhance the methodological quality of future stepped-wedge cluster randomised trial (SW-CRTs). A systematic review of published SW-CRTs shows that pre-trial sample sizes calculations display a poor standard of reporting, with little adherence to published guidelines. The methodological rigor is often substandard, with inappropriate methods often used to determine sample size. In SW-CRTs, it is assumed that the correlation between observations is independent of the timing of them. We test the validity of this assumption by outlining a method
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Butcher, Isabella. "Design and analysis of cluster randomised trials for behavioural interventions." Thesis, Edinburgh Napier University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400594.

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Guarino, Peter David. "Consumer participation in the design of informed consent documentation for entry into randomised clinical trials : a cluster randomised trial." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422313.

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Thomson, Andrew. "Design and analysis issues in cluster randomised trials with binary outcomes." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498595.

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Ukoumunne, Obioha Chukwunyere. "Confidence intervals for the intraclass correlation coefficient in cluster randomised trials." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418293.

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Gomes, Manuel. "Statistical methods for cost-effectiveness analysis that use cluster-randomised trials." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2012. http://researchonline.lshtm.ac.uk/4646546/.

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This thesis considers alternative statistical methods for cost-effectiveness analysis (CEA) that use cluster randomised trials (CRTs). The thesis has four objectives: firstly to develop criteria for identifying appropriate methods for CEA that use CRTs; secondly to critically appraise the methods used in applied CEAs that use CRTs; thirdly to assess the performance of alternative methods for CEA that use CRTs in settings where baseline covariates are balanced; fourthly to compare statistical methods that adjust for systematic covariate imbalance in CEA that use CRTs. The thesis developed a che
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Books on the topic "Cluster randomised trials"

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J, Hayes Richard, and Hayes Richard J. Cluster randomised trials. Taylor & Francis, 2009.

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Eldridge, Sandra. A practical guide to cluster randomised trials in health services research. John Wiley & Sons, 2011.

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Eldridge, Sandra, and Sally Kerry. A Practical Guide to Cluster Randomised Trials in Health Services Research. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119966241.

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Campbell, Michael J. How to design, analyse and report cluster randomised trials in medicine and health related research. John Wiley & Sons, 2014.

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Campbell, Michael J., and Stephen J. Walters. How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118763452.

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Neil, Klar, ed. Design and analysis of cluster randomization trials in health research. Arnold, 2000.

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Coalition Against Malaria in Ethiopia. Effect of a combined use of mosquito repellent and insecticide treated net on malaria prevalence in southern Ethiopia: A cluster randomized controlled trial. Malaria Consortium Ethiopia, 2009.

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Moulton, Lawrence H., and Richard J. Hayes. Cluster Randomised Trials. Taylor & Francis Group, 2017.

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Moulton, Lawrence H., and Richard J. Hayes. Cluster Randomised Trials. Taylor & Francis Group, 2017.

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Moulton, Lawrence H., and Richard J. Hayes. Cluster Randomised Trials. Taylor & Francis Group, 2017.

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Book chapters on the topic "Cluster randomised trials"

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Torgerson, David J., and Carole J. Torgerson. "Cluster Randomised Controlled Trials." In Designing Randomised Trials in Health, Education and the Social Sciences. Palgrave Macmillan UK, 2008. http://dx.doi.org/10.1057/9780230583993_9.

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Moulton, Lawrence H., and Richard J. Hayes. "Cluster Randomized Trials." In Principles and Practice of Clinical Trials. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-52677-5_108-1.

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Kieser, Meinhard. "Cluster-Randomized Trials." In Springer Series in Pharmaceutical Statistics. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49528-2_13.

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Campbell, Michael J. "Cluster Randomized Trials." In Handbook of Epidemiology. Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-09834-0_47.

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M. Crespi, Catherine. "Cluster Randomized Trials." In Textbook of Clinical Trials in Oncology. Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781315112084-11.

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Moulton, Lawrence H., and Richard J. Hayes. "Cluster Randomized Trials." In Principles and Practice of Clinical Trials. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-52636-2_108.

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Humphries, Hilton, Ayesha B. M. Kharsany, Kerry Leask, Fanelesibonge Ntombela, and Quarraisha Abdool Karim. "The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial." In The CAPRISA Clinical Trials: HIV Treatment and Prevention. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47518-9_6.

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Conway, Terry L., and Marc A. Adams. "Cluster Randomized Trial." In Encyclopedia of Quality of Life and Well-Being Research. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-0753-5_415.

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Conway, Terry L., and Marc A. Adams. "Cluster Randomized Trial." In Encyclopedia of Quality of Life and Well-Being Research. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-69909-7_415-2.

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Henderson, William G. "Cluster Randomized Clinical Trials." In Clinical Trials Design in Operative and Non Operative Invasive Procedures. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_10.

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Conference papers on the topic "Cluster randomised trials"

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Birch, Jack, Rebecca Jones, Julia Mueller, et al. "A systematic review of inequalities in the uptake of, adherence to and effectiveness of behavioural weight management interventions." In Building Bridges in Medical Science 2021. Cambridge Medicine Journal, 2021. http://dx.doi.org/10.7244/cmj.2021.03.001.1.

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Background: It has been suggested that interventions focusing on individual behaviour change, such as behavioural weight management interventions, may exacerbate health inequalities. These intervention-generated inequalities may occur at different stages, including intervention uptake, adherence and effectiveness. We conducted a systematic review to synthesise evidence on how different measures of inequality moderate the uptake of, adherence to and effectiveness of behavioural weight management interventions in adults. Methods: We updated a previous systematic literature review from the US Pre
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Xie, Yanli. "Partially Nested Multisite Cluster-Randomized Trials: Estimation, Inference, and Design Randomized Trials." In 2022 AERA Annual Meeting. AERA, 2022. http://dx.doi.org/10.3102/1881725.

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Tiedemann, Anne, Juliana Souza Oliveira, Margaret Allman-Farinelli, et al. "141 Coaching for Healthy AGEing trial – a cluster-randomised controlled trial." In 14th World Conference on Injury Prevention and Safety Promotion (Safety 2022) abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/injuryprev-2022-safety2022.66.

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Rohrer, Doug. "Cluster Randomized Controlled Trial of Interleaved Mathematics Practice." In 2019 AERA Annual Meeting. AERA, 2019. http://dx.doi.org/10.3102/1427791.

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Madan, Ira, Vaughan Parsons, Barry Cookson, et al. "O19-1 The SCIN (skin care intervention in nurses) trial-a cluster randomised trial." In Occupational Health: Think Globally, Act Locally, EPICOH 2016, September 4–7, 2016, Barcelona, Spain. BMJ Publishing Group Ltd, 2016. http://dx.doi.org/10.1136/oemed-2016-103951.94.

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Curtis, J. Randall, Elizabeth L. Nielsen, Patsy D. Treece, et al. "Integrating Palliative And Critical Care: Results Of A Cluster Randomized Trial." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6860.

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Liang, Jenifer, Michael Abramson, Nicholas Zwar, et al. "Management of COPD in Australian general practices: experiences from a cluster randomised trial." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa956.

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Spybrook, Jessaca. "Learning From Cluster Randomized Trials in Education: What Works, for Whom, and Under What Conditions." In 2020 AERA Annual Meeting. AERA, 2020. http://dx.doi.org/10.3102/1574958.

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Berger, C. A., R. Crowder, A. Kityamuwesi, et al. "Digital Adherence Technology for Tuberculosis Treatment Supervision: A Stepped-Wedge Cluster Randomized Trial." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1189.

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Thai, KP. "Accelerating Early Math Learning With a Digital Math Resource: A Cluster Randomized Controlled Trial." In 2019 AERA Annual Meeting. AERA, 2019. http://dx.doi.org/10.3102/1445411.

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Reports on the topic "Cluster randomised trials"

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Ward, Jeanette E., Seham Girgis, Kathryn Thorburn, Stefanie Oliver, Charles Weijer, and Monica Taljaard. A systemic review of self-reported ethical practices in publications of cluster randomised trials conducted in Aboriginal and Torres Strait Islander settings. Edited by Melissa Marshall, Gillian Kennedy, Anna Dwyer, and Sandra Wooltorton. Nulungu Research Institute, The University of Notre Dame Australia, 2021. http://dx.doi.org/10.32613/nrp/2021.4.

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Vera-Hernandez, Marcos, and Brendon McConnell. More powerful cluster randomized control trials. The IFS, 2022. http://dx.doi.org/10.1920/wp.ifs.2022.2222.

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McPhedran, R., K. Patel, B. Toombs, et al. Food allergen communication in businesses feasibility trial. Food Standards Agency, 2021. http://dx.doi.org/10.46756/sci.fsa.tpf160.

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Background: Clear allergen communication in food business operators (FBOs) has been shown to have a positive impact on customers’ perceptions of businesses (Barnett et al., 2013). However, the precise size and nature of this effect is not known: there is a paucity of quantitative evidence in this area, particularly in the form of randomised controlled trials (RCTs). The Food Standards Agency (FSA), in collaboration with Kantar’s Behavioural Practice, conducted a feasibility trial to investigate whether a randomised cluster trial – involving the proactive communication of allergen information a
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Heagerty, Patrick J. Developing Statistical Methods to Improve Stepped-Wedge Cluster Randomized Trials. Patient-Centered Outcomes Research Institute (PCORI), 2021. http://dx.doi.org/10.25302/08.me.150731750.

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Heagerty, Patrick J. Developing Statistical Methods to Improve Stepped-Wedge Cluster Randomized Trials. Patient-Centered Outcomes Research Institute (PCORI), 2021. http://dx.doi.org/10.25302/08.2021.me.150731750.

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Abaluck, Jason, Laura Kwong, Ashley Styczynski, et al. Normalizing Community Mask-Wearing: A Cluster Randomized Trial in Bangladesh. National Bureau of Economic Research, 2021. http://dx.doi.org/10.3386/w28734.

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Villa, Michele, Massimo Le Pera, and Michela Bottega. Quality of Abstracts in Randomized Controlled Trials Published in Leading Critical Care Nursing Journals. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0039.

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Review question / Objective: This review aims to evaluate the methodological quality of RCT-abstracts in leading critical care nursing journals. A methodological quality review with the Consolidated Standards of Reporting Trials (CONSORT) criteria will be performed in RCT-abstracts published between 2011-2021 in the first Scopus-ranking (2021) nursing journals. Eligibility criteria: Abstracts of scientific articles will be included if they fulfil the following inclusion criteria: 1) they report the results of parallel and/or cross-over group RCTs, 2) they are written in English, 3) they refer
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Ahmed, Akhter, Fiona Coleman, John F. Hoddinott, et al. Comparing delivery channels to promote nutrition-sensitive agriculture: A cluster-randomized controlled trial in Bangladesh. International Food Policy Research Institute, 2022. http://dx.doi.org/10.2499/p15738coll2.136473.

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Smith, Lynette M., Nicholas A. Hein, and Danstan S. Bagenda. Cash transfers and HIV/HSV-2 prevalence: a replication of a cluster randomized trial in Malawi. International Initiative for Impact Evaluation (3ie), 2017. http://dx.doi.org/10.23846/rps0012.

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Santhya, K. G., A. J. Zavier, Pallavi Patel, and Neeta Shah. Engaging parents to promote girls' transition to secondary education: Evidence from a cluster randomised trial in rural Gujarat, India. Population Council, 2016. http://dx.doi.org/10.31899/pgy9.1010.

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