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Journal articles on the topic 'CNOT3'

Author: Grafiati

Published: 14 December 2024

Last updated: 19 July 2025

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1

Mittal, Saloni, Akhmed Aslam, Rachel Doidge, Rachel Medica, and G. Sebastiaan Winkler. "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence." Molecular Biology of the Cell 22, no. 6 (2011): 748–58. http://dx.doi.org/10.1091/mbc.e10-11-0898.

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A key step in cytoplasmic mRNA degradation is the shortening of the poly(A) tail, which involves several deadenylase enzymes. Relatively little is known about the importance of these enzymes for the cellular physiology. Here we focused on the role of the highly similar Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the Ccr4–Not complex. In addition to a role in cell proliferation, Ccr4a and Ccr4b play a role in cell survival, in contrast to the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits or the CNOT1 and CNOT3 noncatalytic subunits of the Ccr4–Not complex. Underscoring the d

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2

Zheng, Xiaofeng, Raluca Dumitru, Brad L. Lackford, et al. "Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ESC Identity and Inhibit Extraembryonic Differentiation." STEM CELLS 30, no. 5 (2012): 910–22. http://dx.doi.org/10.1002/stem.1070.

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Elmén, Lisa, Claudia B. Volpato, Anaïs Kervadec, et al. "Silencing of CCR4-NOT complex subunits affects heart structure and function." Disease Models & Mechanisms 13, no. 7 (2020): dmm044727. http://dx.doi.org/10.1242/dmm.044727.

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ABSTRACTThe identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarization). Three of the strongest associating variants (single-nucleotide polymorphisms) are located in the putative promotor region of CNOT1, a gene encoding the central CNOT1 subunit of CCR4-NOT: a multifunctional, conserved complex regulating gene expression and mRNA stability and turnover. We

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McLenachan, Samuel, Dan Zhang, Janya Grainok, et al. "Determinants of Disease Penetrance in PRPF31-Associated Retinopathy." Genes 12, no. 10 (2021): 1542. http://dx.doi.org/10.3390/genes12101542.

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Retinitis pigmentosa 11 (RP11) is caused by dominant mutations in PRPF31, however a significant proportion of mutation carriers do not develop retinopathy. Here, we investigated the relationship between CNOT3 polymorphism, MSR1 repeat copy number and disease penetrance in RP11 patients and non-penetrant carriers (NPCs). We further characterized PRPF31 and CNOT3 expression in fibroblasts from eight RP11 patients and one NPC from a family carrying the c.1205C>T variant. Retinal organoids (ROs) and retinal pigment epithelium (RPE) were differentiated from induced pluripotent stem cells derived

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5

Díaz-Peña, Roberto, Ana M. Aransay, Beatriz Suárez-Álvarez, et al. "A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis." Annals of the Rheumatic Diseases 71, no. 5 (2012): 714–17. http://dx.doi.org/10.1136/annrheumdis-2011-200661.

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ObjectiveTo identify genomic variants in the 19q13 chromosome region associated with ankylosing spondylitis (AS) in human leucocyte antigen (HLA)-B27-positive populations.MethodsHigh-throughput genotyping of 1536 haplotype-tag single nucleotide polymorphisms (SNPs) was performed in 249 patients with AS and 302 healthy controls. Some of the identified associations were validated by genotyping four SNPs in two additional cohorts consisting of 412 cases/301 controls and 144 cases/203 controls. All individuals selected (both cases and controls) were HLA-B27-positive.ResultsTwo markers in two diffe

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6

Banowska, Lidia. "Ironia, cnota i „strach śmieszności”. (Herbert – Norwid)." Studia Norwidiana 40 (September 13, 2022): 37–56. http://dx.doi.org/10.18290/sn2240.2.

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Artykuł dotyczy związku ironii oraz cnoty w poezji Cypriana Norwida oraz Zbigniewa Herberta jako pojęć kluczowych dla twórczości obu autorów i sytuuje się w obszarze badań nad tradycją norwidowską w pisarstwie autora Pana Cogito. Słynny wiersz Herberta Pan Cogito o cnocie zostaje potraktowany jako studium przypadku. Na podstawie interpretacji tego tekstu autorka stawia tezę, iż obrazową matrycą myślenia Herberta o cnocie była wyobraźnia ironiologiczna autora Quidama, a ironia odsłania się jako jedna z możliwych konkretyzacji cnoty. Podstawę dla budowania obrazowych przedstawień obu pojęć stano

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7

Szram, Mariusz. "Can humility exist without poverty? A response by Cappadocian Fathers and John Chrysostom." Vox Patrum 62 (September 4, 2014): 505–10. http://dx.doi.org/10.31743/vp.3599.

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Greccy Ojcowie Kościoła IV w. uznawali zgodnie cnotę pokory za punkt wyjścia na drodze duchowego doskonalenia oraz za matkę wszystkich cnót. W duchu rozwijającego się monastycyzmu podkreślali przede wszystkim ścisły związek pokory z posłuszeństwem jako cnotą najbardziej jej pokrewną. Autor artykułu stara się znaleźć odpowiedź na pytanie, w jaki sposób postrzegali oni relację między pokorą i ubóstwem, mającą głęboką tradycję biblijną. Już w Starym Testamencie ludzie ubodzy (ptoco…) jako znajdujący się w potrzebie byli uważani za szczególnie skromnych i otwartych na pokorne szukanie pomocy u B

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8

Inoue, Takeshi, Masahiro Morita, Atsushi Hijikata, et al. "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability." Journal of Experimental Medicine 212, no. 9 (2015): 1465–79. http://dx.doi.org/10.1084/jem.20150384.

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The CCR4–NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cells remains unclear. Here we show that mice lacking the CNOT3 subunit of this complex, specifically in B cells, have a developmental block at the pro- to pre–B cell transition. CNOT3 regulated generation of germline transcripts in the VH region of the immunoglobulin heavy chain (Igh) locus, compaction of the locus, and subsequent Igh gene r

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9

Rodriguez-Gil, Alfonso, Olesja Ritter, Juliane Hornung, et al. "HIPK family kinases bind and regulate the function of the CCR4-NOT complex." Molecular Biology of the Cell 27, no. 12 (2016): 1969–80. http://dx.doi.org/10.1091/mbc.e15-09-0629.

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The serine/threonine kinase HIPK2 functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates. Because the kinase is generated in a constitutively active form, its expression levels are restricted by a variety of different mechanisms. Here we identify the CCR4-NOT complex as a new regulator of HIPK2 abundance. Down-regulation or knockout of the CCR4-NOT complex member CNOT2 leads to reduced HIPK2 protein levels without affecting the expression level of HIPK1 or HIPK3. A fracti

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10

Głąb, Anna. "Cnota, charakter, dobroć. W nawiązaniu do powieści autobiograficznej Raimonda Gaity Mój ojciec Romulus." Roczniki Filozoficzne 68, no. 1 (2020): 49–75. http://dx.doi.org/10.18290/rf20681-3.

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Przedmiotem tekstu jest rozróżnienie między dobrocią i cnotą oraz złem i występkiem, wprowadzone przez Hannah Arendt na podstawie lektury powieści Hermanna Melville’a Billy Budd. Rozróżnienie to analizuję, odnosząc się do historii życia Romulusa Gaity, bohatera powieści autobiograficznej Mój ojciec Romulus, której autorem jest australijski etyk Raimond Gaita. W paragrafie 1 zajmuję się ową dystynkcją, wskazując na przewartościowanie takich pojęć, jak cnota i występek w powieści Melville’a oraz jego rozumienie cnoty. Następnie (paragraf 2) staram się odpowiedzieć na pytanie, dlaczego Gaita pisz

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Kaur, Ishwinder, Gopal P. Jadhav, Peter M. Fischer, and Gerlof Sebastiaan Winkler. "The Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease." Molecules 29, no. 18 (2024): 4351. http://dx.doi.org/10.3390/molecules29184351.

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The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a structural function by mediating interactions between the large, non-catalytic subunit CNOT1, which forms the backbone of the Ccr4-Not complex and the second nuclease subunit Ccr4 (CNOT6/CNOT6L). To facilitate investigations into the role of Caf1/CNOT7 in gene regulation, we aimed to discover and develop non-nucleoside inhibitors of the enzyme

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12

Serdar, Lucas D., Jacob R. Egol, Brad Lackford, Brian D. Bennett, Guang Hu, and Debra L. Silver. "mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis." PLOS Biology 23, no. 2 (2025): e3003031. https://doi.org/10.1371/journal.pbio.3003031.

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RNA abundance is controlled by rates of synthesis and degradation. Although mis-regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes to cortical development is largely unknown. Here, we discover the landscape of RNA stability regulation in the cerebral cortex and demonstrate that intact RNA decay machinery is essential for corticogenesis in vivo. We use SLAM-seq to measure RNA half-lives transcriptome-wide across multiple stages of cortical development. Leveraging these data, we discover cis-acting features associated with RNA stability and probe the relatio

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13

Zheng, Xiaofeng, Pengyi Yang, Brad Lackford, et al. "CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State." Stem Cell Reports 7, no. 5 (2016): 897–910. http://dx.doi.org/10.1016/j.stemcr.2016.09.007.

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14

Abui, Abui Abraham. "The Vices against the Virtue of Temperance among the Atyap Cultural Heritage of Africa: A Philosophical Approach." Roczniki Kulturoznawcze 10, no. 4 (2020): 161–77. http://dx.doi.org/10.18290/rkult.2019.10.4-8.

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Wady odpowiadające cnocie umiarkowania w kulturowym dziedzictwie szczepu Atyap: podejście filozoficzne W dyskursie moralnym cnoty wciąż zajmują centralne miejsce. Dzieje się tak, ponieważ dyskusje o moralności obracają się wokół pojęć cnoty i wady. Bierze się za pewnik, że wynikiem cnót są czyny dobre moralnie, natomiast wady prowadzą do czynów złych, powszechnie potępianych. Etycy cnót opierają swoje argumenty na założeniu, że czyny ludzkie są bezpośrednio połączone bądź to z cnotą, bądź z wadą. Każdej cnocie odpowiada nadmiar lub deficyt, którego przekroczenie wiąże się z przeciwną jej

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15

Manuela, Priolo, Radio Francesca Clementina, Pizzi Simone, et al. "Co-Occurring Heterozygous CNOT3 and SMAD6 Truncating Variants: Unusual Presentation and Refinement of the IDDSADF Phenotype." Genes 12, no. 7 (2021): 1009. http://dx.doi.org/10.3390/genes12071009.

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Objective, the application of genomic sequencing in clinical practice has allowed us to appreciate the contribution of co-occurring pathogenic variants to complex and unclassified clinical phenotypes. Besides the clinical relevance, these findings have provided evidence of previously unrecognized functional links between genes in the context of developmental processes and physiology. Patients and Methods, a 5-year-old patient showing an unclassified phenotype characterized by developmental delay, speech delay, peculiar behavioral features, facial dysmorphism and severe cardiopathy was analyzed

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16

Cejas, Paloma, Alessia Cavazza, C. N. Yandava, et al. "Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype." Cancer Research 77, no. 3 (2016): 766–79. http://dx.doi.org/10.1158/0008-5472.can-16-1346.

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17

Watanabe, C., M. Morita, T. Hayata, et al. "Stability of mRNA influences osteoporotic bone mass via CNOT3." Proceedings of the National Academy of Sciences 111, no. 7 (2014): 2692–97. http://dx.doi.org/10.1073/pnas.1316932111.

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18

Kieliszek, Zdzisław. "Męstwo a świętość." Studia Warmińskie 49 (December 31, 2012): 9–22. http://dx.doi.org/10.31648/sw.250.

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W artykule Męstwo a świętość autor, zainspirowany hasłem X Dnia Papieskiego „Odwaga świętości”, który był obchodzony w Polsce 10 października 2010 r., próbuje określić relację pomiędzy cnotą męstwa a świętością. W pierwszej części rozważań analizie poddana zostaje cnota męstwa. Zostaje ona ukazana jako cierpliwe, wytrwałe i ufne stawienie oporu złu, oraz długomyślne i wielkoduszne dążenie do prawdy, dobra i piękna. Część druga jest poświęcona refleksji nad świętością. W świetle prowadzonych badań jawi się ona jako wartość, którą człowiek realizuje, dążąc do doskonałości. W ostatniej części zos

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Eskandarian, Samira, Roger J. Grand, Shiva Irani, Mohsen Saeedi, and Reza Mirfakhraie. "Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)." Journal of Cancer Research and Therapeutics 20, no. 1 (2023): 126–32. http://dx.doi.org/10.4103/jcrt.jcrt_1723_22.

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Background: The Ccr4–Not complex (CNOT complex in mammals) is a unique and highly conserved complex with numerous cellular functions. Until now, there has been relatively little known about the importance of the CNOT complex subunits in the DNA damage response (DDR) in mammalian cells. CNOT4 is a subunit of the complex with E3 ubiquitin ligase activity that interacts transiently with the CNOT1 subunit. Here, we attempt to investigate the role of human CNOT4 subunit in the DDR in human cells. Material and Methods: In this study, cell viability in the absence of CNOT4 was assessed using a Cell T

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Chang, Nai-Wen, та Yi-Ping Huang. "The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis". BioMedicine 9, № 4 (2019): 27. http://dx.doi.org/10.1051/bmdcn/2019090427.

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Background: The activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis. Methods: In this study, we used a pathway-based strategy to explore possible functional pathways involved in the anticancer activity of PPARα in oral cancer cells through next-generation sequencing (NGS) and bioinformatic approaches. Results: We found that 3919 genes were upregulated and 1060 genes were downregulated through PPARα activation. These genes were mainly involved in the proteasomal, mRN

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Martin, R., M. Splitt, D. Genevieve, et al. "De novo variants in CNOT3 cause a variable neurodevelopmental disorder." European Journal of Human Genetics 27, no. 11 (2019): 1677–82. http://dx.doi.org/10.1038/s41431-019-0413-6.

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22

Doidge, Rachel, Saloni Mittal, Akhmed Aslam, and G. Sebastiaan Winkler. "Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex." Biochemical Society Transactions 40, no. 4 (2012): 896–901. http://dx.doi.org/10.1042/bst20120074.

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The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease–exonuclease–phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4–Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechani

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Seki, Masafumi, Kenichi Yoshida, Yusuke Sato, et al. "Genetic Landscapes Of Childhood T-Cell Acute Lymphoblastic Leukemia." Blood 122, no. 21 (2013): 3786. http://dx.doi.org/10.1182/blood.v122.21.3786.3786.

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Abstract T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10% to 15% of newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL). Generally, childhood T-ALL patients have a worse prognosis than B cell precursor ALL patients. Recent studies have identified a subtype of T-ALL termed “early T-cell precursor” (ETP) ALL, which is associated with a high risk of treatment failure. In spite of recent improvements of risk stratified multiagent chemotherapy, relapsed patients have a poor prognosis even if they were non-ETP ALL. Recent genome-wide approach revealed frequent NOTCH1 an

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24

Smółka, Lucyna. "O potrzebie umiaru w kulturze nadmiaru." Horyzonty Wychowania 19, no. 52 (2020): 35–44. http://dx.doi.org/10.35765/hw.1858.

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CEL NAUKOWY: Celem artykułu jest konceptualizacja cnoty umiarkowania, wskazanie konsekwencji zaniedbania tej sprawności moralnej w kulturze konsumpcji, wyeksponowanie współczesnej etyki cnoty jako perspektywy rozważań nad konsumpcją etyczną. PROBLEM I METODY BADAWCZE: Przedstawiony problem badawczy dotyczy odpowiedzi na pytania: Czym jest umiarkowanie? Jak brak umiaru w kulturze konsumpcyjnej wpływa na życie ludzi? Jakich praktycznych wskazówek w kwestii etycznej konsumpcji może dostarczyć nam współczesna etyka cnót? Zastosowano metodę analityczno-syntetyczną literatury przedmiotu.

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Delacruz, Richard Glenn C., Imelda T. Sandoval, Kyle Chang, et al. "Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas." Oncotarget 10, no. 39 (2019): 3939–51. http://dx.doi.org/10.18632/oncotarget.27003.

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26

Takahashi, Akinori, Chisato Kikuguchi, Masahiro Morita, et al. "Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression." Biochemical and Biophysical Research Communications 419, no. 2 (2012): 268–73. http://dx.doi.org/10.1016/j.bbrc.2012.02.007.

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Lv, Jin, Wen-Jie Ming, Yang Zheng, et al. "A novel pathogenic variant in CNOT3 causing neurodevelopmental delay and epilepsy." Seizure 107 (April 2023): 104–6. http://dx.doi.org/10.1016/j.seizure.2023.03.022.

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Vattathil, Selina M., Yue Liu, Nadia V. Harerimana, et al. "A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3." Genes 12, no. 6 (2021): 815. http://dx.doi.org/10.3390/genes12060815.

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Cerebral atherosclerosis is a leading cause of stroke and an important contributor to dementia. Yet little is known about its genetic basis. To examine the association of common single nucleotide polymorphisms with cerebral atherosclerosis severity, we conducted a genomewide association study (GWAS) using data collected as part of two community-based cohort studies in the United States, the Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP). Both studies enroll older individuals and exclude participants with signs of dementia at baseline. From our analysis of 1325 participant

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Lisbjerg, Kristian, Karen Grønskov, Mette Bertelsen, Lisbeth Birk Møller, and Line Kessel. "Genetic Modifiers of Non-Penetrance and RNA Expression Levels in PRPF31-Associated Retinitis Pigmentosa in a Danish Cohort." Genes 14, no. 2 (2023): 435. http://dx.doi.org/10.3390/genes14020435.

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(1) Background/aims: To examine potential genetic modifiers of disease penetrance in PRPF31-associated retinitis pigmentosa 11 (RP11). (2) Methods: Blood samples from individuals (n = 37) with PRPF31 variants believed to be disease-causing were used for molecular genetic testing and, in some cases (n = 23), also for mRNA expression analyses. Medical charts were used to establish if individuals were symptomatic (RP) or asymptomatic non-penetrant carriers (NPC). RNA expression levels of PRPF31 and CNOT3 were measured on peripheral whole blood using quantitative real-time PCR normalized to GAPDH.

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Seki, Masafumi, Kenichi Yoshida, Shiraishi Yuichi, et al. "Whole Exome and Transcriptome Analyses in Pediatric T-Cell Acute Lymphoblastic Leukemia." Blood 124, no. 21 (2014): 3527. http://dx.doi.org/10.1182/blood.v124.21.3527.3527.

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Abstract T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10% to 15% of newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL). Recent genome-wide approach revealed frequent NOTCH1 and FBXW7 oncogenic mutations in T-ALL. In addition, previous whole-exome sequencing disclosed novel CNOT3 mutations in approximately 10% of adult T-ALL cases, and thus, CNOT3 is thought to be one of the novel tumor suppressor gene for adult T-ALL. However, somatic mutations in these genes have been found in a fraction of childhood T-ALL, suggesting that the existence of other genetic pathogen

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Jing, Lin, Meng-En Zhai, Jian Cui, et al. "CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression." Apoptosis 24, no. 7-8 (2019): 673–85. http://dx.doi.org/10.1007/s10495-019-01550-y.

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Pavanello, Lorenzo, Benjamin Hall, Blessing Airhihen, and Gerlof Sebastiaan Winkler. "The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4–Not nuclease module." Biochemical Journal 475, no. 21 (2018): 3437–50. http://dx.doi.org/10.1042/bcj20180456.

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Regulated degradation of cytoplasmic mRNA is important for the accurate execution of gene expression programmes in eukaryotic cells. A key step in this process is the shortening and removal of the mRNA poly(A) tail, which can be achieved by the recruitment of the multi-subunit Ccr4–Not nuclease complex via sequence-specific RNA-binding proteins or the microRNA machinery. The Ccr4–Not complex contains several modules that are attached to its large subunit CNOT1. Modules include the nuclease module, which associates with the MIF4G domain of CNOT1 and contains the catalytic subunits Caf1 and Ccr4

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Aslam, Akhmed, Saloni Mittal, Frederic Koch, Jean-Christophe Andrau, and G. Sebastiaan Winkler. "The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation." Molecular Biology of the Cell 20, no. 17 (2009): 3840–50. http://dx.doi.org/10.1091/mbc.e09-02-0146.

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Accurate gene expression requires the precise control of mRNA levels, which are determined by the relative rates of nuclear (pre-)mRNA synthesis and processing, and cytoplasmic mRNA turnover. A key step in mRNA degradation is the removal of the poly(A) tail, which involves several deadenylases including components of the Ccr4–Not complex. Here, we focused on the role of the human paralogues CNOT7 (hCaf1/Caf1a) and CNOT8 (hPop2/Caf1b/Calif), which possess deadenylase activity mediated by DEDD nuclease domains. We show that efficient proliferation requires both subunits, although combined knockd

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Shirai, Yo-Taro, Anna Mizutani, Saori Nishijima, et al. "CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development." Oncogene 38, no. 14 (2018): 2580–94. http://dx.doi.org/10.1038/s41388-018-0603-7.

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Venturini, Giulia, Anna M. Rose, Amna Z. Shah, Shomi S. Bhattacharya, and Carlo Rivolta. "CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance." PLoS Genetics 8, no. 11 (2012): e1003040. http://dx.doi.org/10.1371/journal.pgen.1003040.

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Ghashghaei, Maryam, Marty Yue, Aaremish Arsalan, et al. "RNA Deadenylation Subunit CNOT3 Promotes Myeloid Leukemia By Driving Translation of Oncogenic Targets." Blood 140, Supplement 1 (2022): 2962–63. http://dx.doi.org/10.1182/blood-2022-163026.

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Koszkało, Martyna. "Arystoteles, Tomasz z Akwinu, Jan Duns Szkot: Kilka uwag o różnicy między starożytnym i średniowiecznym pojmowaniem cnoty." Roczniki Filozoficzne 72, no. 2 (2024): 489–510. http://dx.doi.org/10.18290/rf24722.24.

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Artykuł przedstawia grecki ideał człowieka cnotliwego prezentowany w koncepcji Arystotelesa w kontraście do odpowiednika tego ideału obecnego w kulturze chrześcijańskiej (Tomasz z Akwinu, Jan Duns Szkot). Pewne elementy etyki Arystotelesa wzbudzały bowiem kontrowersje, szczególnie elitaryzm oraz model megalópsychos i musiały zostać w etyce chrześcijańskiej przekształcone. Ze względu na nowy model antropologiczny (człowieka jako istoty grzesznej) pojęcie cnoty uległo pewnej modyfikacji zwłaszcza w nurtach woluntarystycznych, gdyż cnotliwy człowiek, mimo posiadania dobrego charakteru, jest w ram

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Vu, Ly, Aaremish Arsalan, Guiseppe Bombaci, et al. "3219 – RNA DEADENYLATION SUBUNIT CNOT3 PROMOTES MYELOID LEUKEMIA BY DRIVING TRANSLATION OF ONCOGENIC TARGETS." Experimental Hematology 111 (2022): S154. http://dx.doi.org/10.1016/j.exphem.2022.07.275.

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Meyer, Robert, Matthias Begemann, Stephanie Demuth, et al. "Inherited cases of CNOT3 ‐associated intellectual developmental disorder with speech delay, autism, and dysmorphic facies." Clinical Genetics 98, no. 4 (2020): 408–12. http://dx.doi.org/10.1111/cge.13819.

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Celary, Ireneusz. "Pastoraltheologische Vorschläge von Papst Franziskus für Ältere Priester und Ordensleute." Warszawskie Studia Pastoralne 1, no. 34 (2018): 169. http://dx.doi.org/10.21697/wsp.2017.12.1.34.09.

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Niniejszy artykuł, oparty na analizie nauczania papieża Franciszka, dotyczy sytuacji starszych kapłanów i osób zakonnych w dzisiejszym świecie. Zawiera pastoralno-teologiczne propozycje względem nich. Papież mówił o nich w wielu swoich przemówieniach i innych dokumentach. Czynił to, analizując trzy ewangeliczne cnoty: ubóstwo, bezżeństwo i posłuszeństwo. Publikacja składa się z trzech rozdziałów. Pierwszy zawiera rozważania pa-pieża na temat realizacji cnoty ubóstwa w życiu starszych kapłanów i osób zakonnych. Drugi ukazuje przemyślenia papieża na temat realizacji – w ich posłudze – cnoty bezż

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Łojek, Stanisław. "Kim jest megalopsychos?" Etyka 40 (December 1, 2007): 115–29. http://dx.doi.org/10.14394/etyka.435.

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Celem niniejszego artykułu jest przybliżenie tajemniczej i kontrowersyjnej cnoty megalopsychii („wielkoduszności”), którą Arystoteles opisuje w czwartej księdze Etyki nikomachejskiej. Badając jej rodowód (sięgający ethosu starohelleńskiej szlachty) oraz etyczny kontekst, w jakim może ona mieć doniosłość, staram się wykazać, iż dostarcza ona alternatywnego ujęcia cnoty w porównaniu z jej rozumieniem „klasycznym”. A ponieważ to ostatnie opiera się na metafizycznych założeniach, które w dzisiejszych czasach utraciły wiarygodność, właśnie cnota „wielkoduszności” — odwołująca się do znacznie nam bl

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Pinard, Amélie, Stéphanie Guey, Dongchuan Guo, et al. "The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy." Genetics in Medicine 22, no. 2 (2019): 427–31. http://dx.doi.org/10.1038/s41436-019-0639-2.

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Baran, Grzegorz. "Ἀρετή w świetle „Listu Arysteasza do Filokratesa”". Polonia Sacra 29, № 2 (2025): 169–206. https://doi.org/10.15633/ps.29209.

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„List Arysteasza do Filokratesa” to apokryf/pseudoepigraf powstały w kręgu judaizmu hellenistycznego. Jedną z kwestii poruszonych w tym dziele jest określenie, czym jest cnota. Dokładna analiza treści „Listu” (zwłaszcza fragmentów, w których występuje termin ἀρετή) pozwala zauważyć, że jego autor — próbując zdefiniować cnotę — wyraźnie nawiązał zarówno do nurtów filozofii greckiej, jak również do tradycji starotestamentalnej. Celem artykułu jest zatem wykazanie, do jakich systemów filozoficznych odwołał się autor „Listu”, określając cnotę, i w jaki sposób opisywaną przez siebie ἀρετή powiązał

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Braun, Rachel M., Max Ferretti, Jesse Miller, et al. "Host mRNA deadenylation machinery selectively targets interferon mRNAs, regulating antiviral immunity." Journal of Immunology 210, no. 1_Supplement (2023): 236.08. http://dx.doi.org/10.4049/jimmunol.210.supp.236.08.

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Abstract Elucidating host-mediated regulation of viral infection is critical in the development of antivirals and in understanding viral pathogenesis. Here, through high-throughput RNA interference screening, we determine that CNOT2 promotes SARS-CoV-2 infection in human respiratory epithelial cells. CNOT2 is a non-enzymatic subunit of the CCR4-NOT complex, which plays conserved roles in the control of gene expression by deadenylating the poly(A) tails of host mRNAs, thus targeting them for decay. CCR4-NOT can selectively degrade cohorts of mRNAs that are delivered by RNA Binding Proteins. Tri

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Jung, Ji Hoon, Duckgue Lee, Hyun Min Ko, and Hyeung-Jin Jang. "Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53." Biomolecules 11, no. 10 (2021): 1492. http://dx.doi.org/10.3390/biom11101492.

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CCR4-NOT transcription complex subunit 2 (CNOT2), a subunit of the CCR4-NOT complex, has been described in cancer progression. The CNOT complex plays an important role in multiple cellular functions. Recent studies in our laboratory showed that CNOT2 promotes breast cancer cell proliferation and angiogenesis. In addition, CNOT2 signals are critically related to apoptosis induced by atorvastatin in lung cancer cells. Furthermore, depletion of CNOT2 was shown to enhance the antitumor effect of midline 1 interacting protein 1 (MID1IP1) depletion, thus inhibiting c-Myc expression in liver cancer c

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De Keersmaecker, Kim, Zeynep Kalender Atak, Ning Li, et al. "Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia." Nature Genetics 45, no. 2 (2012): 186–90. http://dx.doi.org/10.1038/ng.2508.

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Raszewska-Żurek, Beata. "Kobieca cnota. Próba zrozumienia ewolucji znaczenia cnoty na przestrzeni wieków." Studia z Filologii Polskiej i Słowiańskiej 46 (September 25, 2015): 83–102. http://dx.doi.org/10.11649/sfps.2011.006.

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Feminine virtue. An attempt at understanding the evolution of the meaning of cnota (virtue) over the centuriesThe article is devoted to the evolution of the meaning of the Polish lexeme cnota (virtue) starting from the Old Polish to the present time. The starting point is the change in the meaning of the lexeme virtue from the ‘complex of ethical qualities’ in the Old Polish language to the ‘hymen’ in the twentieth century. From the beginning of the Polish language, the lexeme virtue contained a different catalogue of values in relation to men and women. Analysis concerned these meanings which

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Mao, Qingyan, Qianfeng Zhuang, Jie Shen, et al. "MiRNA-124 regulates the sensitivity of renal cancer cells to cisplatin-induced necroptosis by targeting the CAPN4-CNOT3 axis." Translational Andrology and Urology 10, no. 9 (2021): 3669–83. http://dx.doi.org/10.21037/tau-21-777.

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Meijer, Hedda A., Tobias Schmidt, Sarah L. Gillen, et al. "DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity." Nucleic Acids Research 47, no. 15 (2019): 8224–38. http://dx.doi.org/10.1093/nar/gkz509.

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Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact directly with the MA3 and MIF domains of CNOT1 and compete for binding. Furthermore, we now show that incorporation of eIF4A2 into the CCR4–NOT complex inhibits CNOT7 deadenylation activity in contrast to DDX6 which enhances CNOT7 activity. Polyadenylation tests (PAT) on endogenous mRNAs determined that eIF4A2 bound mRNAs have longer poly(A)

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Yamaguchi, Tomokazu, Ryo Ozawa, Takafumi Minato, et al. "Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes." Journal of Inflammation Research Volume 17 (August 2024): 5415–25. http://dx.doi.org/10.2147/jir.s468612.

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