Academic literature on the topic 'CNTN3'

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Journal articles on the topic "CNTN3"

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Kalafatakis, Ilias, Maria Savvaki, Theodora Velona, and Domna Karagogeos. "Implication of Contactins in Demyelinating Pathologies." Life 11, no. 1 (2021): 51. http://dx.doi.org/10.3390/life11010051.

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Demyelinating pathologies comprise of a variety of conditions where either central or peripheral myelin is attacked, resulting in white matter lesions and neurodegeneration. Myelinated axons are organized into molecularly distinct domains, and this segregation is crucial for their proper function. These defined domains are differentially affected at the different stages of demyelination as well as at the lesion and perilesion sites. Among the main players in myelinated axon organization are proteins of the contactin (CNTN) group of the immunoglobulin superfamily (IgSF) of cell adhesion molecul
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Oshima, Sachi, Shunichi Asai, Naohiko Seki, et al. "Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma." International Journal of Molecular Sciences 22, no. 12 (2021): 6199. http://dx.doi.org/10.3390/ijms22126199.

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We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-31-3p). The aims of this study were to identify networks of tumor suppressor genes regulated by miR-31-5p and miR-31-3p in HNSCC cells. Our functional assays showed that inhibition of miR-31-5p and miR-31-3p attenuated cancer cell malignant phenotypes (cell proliferation, migration, and invasion), suggesting that they had oncogenic potential in HNSCC
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Zhou, Jie, Zhiman Xie, Ping Cui, et al. "SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer." BioMed Research International 2020 (May 27, 2020): 1–12. http://dx.doi.org/10.1155/2020/1204605.

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Background. This study is aimed at identifying unknown clinically relevant genes involved in colorectal cancer using bioinformatics analysis. Methods. Original microarray datasets GSE107499 (ulcerative colitis), GSE8671 (colorectal adenoma), and GSE32323 (colorectal cancer) were downloaded from the Gene Expression Omnibus. Common differentially expressed genes were filtered from the three datasets above. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed, followed by construction of a protein-protein interaction network to identify hub genes. K
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Morris, Julia, Soddy Sau Yu Leung, Mark E. S. Bailey, et al. "Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank." Genes 11, no. 11 (2020): 1326. http://dx.doi.org/10.3390/genes11111326.

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Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association studies, in a wide range of psychological, psychiatric and cardiometabolic conditions. Contactins a
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Peng, Xi, John Williams, Philip M. Smallwood, and Jeremy Nathans. "Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis." PLOS ONE 14, no. 7 (2019): e0219384. http://dx.doi.org/10.1371/journal.pone.0219384.

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Carvalho, M. E., F. S. Baldi, M. H. A. Santana, et al. "Identification of genomic regions related to tenderness in Nellore beef cattle." Advances in Animal Biosciences 8, s1 (2017): s42—s44. http://dx.doi.org/10.1017/s2040470017001674.

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The aim of this study was to identify genomic regions that associated with beef tenderness in Nellore cattle. Phenotypes were obtained according to the standard USDA Quality Grade (1999). Data from 909 genotyped Nellore bulls were used in the Genome-Wide Association Study (GWAS) undertaken using a single-step approach including also a pedigree file composed of 6276 animals. The analyses were performed using the Blupf90 software, estimating the effect of genomic windows of 10 consecutive markers. The GWAS results identified 18 genomic regions located on 14 different chromosomes (1, 4, 6, 7, 8,
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Tassano, Elisa, Sara Uccella, Thea Giacomini, et al. "Clinical and Molecular Characterization of Two Patients with CNTN6 Copy Number Variations." Cytogenetic and Genome Research 156, no. 3 (2018): 144–49. http://dx.doi.org/10.1159/000494152.

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Submicroscopic chromosomal alterations usually involve different protein-coding genes and regulatory elements that are responsible for rare contiguous gene disorders, which complicate the understanding of genotype-phenotype correlations. Chromosome band 3p26.3 contains 3 genes encoding neuronal cell adhesion molecules: CHL1, CNTN6, and CNTN4. We describe 2 boys aged 8 years and 11 years mainly affected by intellectual disability and autism spectrum disorder, who harbor a paternally inherited 3p26.3 microdeletion and a 3p26.3 microduplication, respectively. Both anomalies involved only the CNTN
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Lu, Xubin, Ismail Mohamed Abdalla, Mudasir Nazar, et al. "Genome-Wide Association Study on Reproduction-Related Body-Shape Traits of Chinese Holstein Cows." Animals 11, no. 7 (2021): 1927. http://dx.doi.org/10.3390/ani11071927.

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Reproduction is an important production activity for dairy cows, and their reproductive performance can directly affect the level of farmers’ income. To better understand the genomic regions and biological pathways of reproduction-related traits of dairy cows, in the present study, three body shape traits—Loin Strength (LS), Rump Angle (RA), and Pin Width (PW)—were selected as indicators of the reproductive ability of cows, and we conducted genome-wide association analyses on them. The heritability of these three traits was medium, ranging from 0.20 to 0.38. A total of 11 significant single-nu
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Gu, Yan, Taosha Li, Anil Kapoor, Pierre Major, and Damu Tang. "Contactin 1: An Important and Emerging Oncogenic Protein Promoting Cancer Progression and Metastasis." Genes 11, no. 8 (2020): 874. http://dx.doi.org/10.3390/genes11080874.

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Even with recent progress, cancer remains the second leading cause of death, outlining a need to widen the current understanding on oncogenic factors. Accumulating evidence from recent years suggest Contactin 1 (CNTN1)’s possession of multiple oncogenic activities in a variety of cancer types. CNTN1 is a cell adhesion molecule that is dysregulated in many human carcinomas and plays important roles in cancer progression and metastases. Abnormalities in CNTN1 expression associate with cancer progression and poor prognosis. Mechanistically, CNTN1 functions in various signaling pathways frequently
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Marell, Paulina S., Sharon E. Blohowiak, Michael D. Evans, Michael K. Georgieff, Pamela J. Kling, and Phu V. Tran. "Cord Blood-Derived Exosomal CNTN2 and BDNF: Potential Molecular Markers for Brain Health of Neonates at Risk for Iron Deficiency." Nutrients 11, no. 10 (2019): 2478. http://dx.doi.org/10.3390/nu11102478.

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Maternal iron deficiency anemia, obesity, and diabetes are prevalent during pregnancy. All are associated with neonatal brain iron deficiency (ID) and neurodevelopmental impairment. Exosomes are extracellular vesicles involved in cell–cell communication. Contactin-2 (CNTN2), a neural-specific glycoprotein, and brain-derived neurotrophic factor (BDNF) are important in neurodevelopment and found in exosomes. We hypothesized that exosomal CNTN2 and BDNF identify infants at risk for brain ID. Umbilical cord blood samples were measured for iron status. Maternal anemia, diabetes, and body mass index
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Dissertations / Theses on the topic "CNTN3"

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Konyukh, Marina. "Copy number variations in autism spectrum disorders : identification and characterization of new candidate genes ( SEZ6L2 ans CNTN3-6)." Paris 7, 2010. http://www.theses.fr/2010PA077235.

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Les troubles du spectre autistique (TSA) sont caractérisés par un déficit de la communication sociale et des comportements stéréotypés. Des études d'agrégation familiales et sur les jumeaux ont indiqué que les TSA ont une composante génétique forte. Récemment, l'étude du génome à grande échelle et à haute résolution a révélé des variations du nombre de copies (CNV). Un des CNV les plus fréquemment observés chez les patients atteints de TSA est la délétion/duplication localisée dans la région chromosomique 16pl 1. 2. Parmi les gènes situés dans ce CNV, des analyses montre que SEZ6L2, pourrait ê
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Lin, Shu-Hong. "Modulation of Protein Tyrosine Phosphatase (PTPγ) Signaling by MicroRNA and Ligand Binding". The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312311825.

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Weeranantanapan, Oratai. "The role of L1-CNTNs in controlling SHH-induced proliferation of cerebellar granule neuron progenitors." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6180/.

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Medway, Christopher William. "Exploring the association of common and rare variants in CNTN2, FGA and SPARCL1 with late-onset Alzheimer’s disease." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588064.

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Alzheimer's disease (AD) is an incurable neurodegenerative disorder, and the most common form of dementia, characterised neuropathologically by Aβ plaques and tau tangles. Although the late-onset form of AD (LOAD) is highly heritable (-80%), genetic studies to date have only accounted for approximately half of this. Identification of the remaining risk may require new approaches. In this thesis three candidate genes/loci (CNTN2, FGA and SPARCL 1), encoding putative LOAD cerebro-spinal fluid biomarkers (Contactin-2, Fibrinogen alpha-chain and Sparc-like-1), have been subjected to complementary
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Lee, Wei-Ting, and 李韋廷. "Study of Carbon Nanotube Network (CNTN) Synthesized by Alcohol Catalytic Chemical-Vapor-Deposition as Interconnect of Advanced Metal-Oxide-Semiconductor Devices." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/64h8k5.

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碩士<br>國立虎尾科技大學<br>機械與機電工程研究所<br>97<br>In this thesis, the synthesizing high-quality carbon nanotube network (CNTN) has been developed directly by means of the low-temperature catalytic CVD method using ethanol (ACCVD). A metal acetate solution was prepared by dissolving molybdenum acetate and cobalt acetate into ethanol. By modulated the various growth temperatures and time, as well as various pre-treatments, the high-quality CNTN can be achieved for interconnect of the metal-oxide-semiconductor (MOS) device applications. To reduce the resistance of the CNTN, the CNTN was treated by the H2SO4:
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Book chapters on the topic "CNTN3"

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Fernandez, Thomas. "CNTN4: Contactin 4." In Encyclopedia of Autism Spectrum Disorders. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1320.

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Fernandez, Thomas. "CNTN4: Contactin 4." In Encyclopedia of Autism Spectrum Disorders. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_1320.

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"CNTN4." In Encyclopedia of Autism Spectrum Disorders. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_100319.

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"CNTN4." In Encyclopedia of Autism Spectrum Disorders. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_300359.

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Cass, Carol E., Stephen A. Baldwin, and James Young. "CNT3, Concentrative Nucleoside Transporter 3." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.62900-9.

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Conference papers on the topic "CNTN3"

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Gu, Yan Jennifer, Wenjuan Mei, Geoffrey A. Wood, and Damu Tang. "Abstract 1621: Contactin 1 (CNTN1) promotes prostate cancer tumorigenesis in transgenic models." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1621.

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Kim, Soon-Chan, Chang-Won Hong, Sang-Geun Jang, et al. "Abstract 1642: Calponin-3, acidic (CNN3) mediates EMT-related genes in human colorectal cancer metastasis." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1642.

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Cha, Mi Young, Bu-Nam Jeon, Areum Jeong, et al. "Abstract 492: CNTN4 is a novel immune checkpoint protein that inhibits proliferation of T cell by interacting with APP." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-492.

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Abdel-Rahman, WM, V. Nair, and N. Al-khayyal. "PO-206 Calponin 3 (CNN3) promotes epithelial to mesenchymal transition and drug resistance of colon cancer cells." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.241.

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Cha, Mi Young, Youn Kyung Houh, Yun Yeon Kim, et al. "Abstract 688: Anti-CNTN4 antibody, GENA-104A07 suppresses tumor growth in murine syngeneic tumor models by regulating T cell function." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-688.

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