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1

Senate, United States Congress. A bill to amend title XVIII of the Social Security Act to require prompt payment to pharmacies under part D, to restrict pharmacy co-branding on prescription drug cards issued under such part, and to provide guidelines for Medication Therapy Management Services programs offered by prescription drug plans and MA-PD plans under such part. U.S. G.P.O., 2007.

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2

United States. Congress. Senate. A bill to amend title XVIII of the Social Security Act to require prompt payment to pharmacies under part D, to restrict pharmacy co-branding on prescription drug cards issued under such part, and to provide guidelines for Medication Therapy Management Services programs offered by prescription drug plans and MA-PD plans under such part. U.S. G.P.O., 2006.

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3

Drake, Robert E., Matthew R. Merrens, and Mark McGovern. Medication Management for People with Co-Occurring Disorders. Hazelden, 2014.

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4

Medication Management of Co-Occurring Opioid Use Disorder in Mental Health Settings: A Guide for Practitioners. RAND Corporation, 2021. http://dx.doi.org/10.7249/tla928-2.

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5

Soule, Michael, and Hilary S. Connery. Co-occurring Substance Use Disorders. Edited by Hunter L. McQuistion. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190610999.003.0020.

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Substance use disorders are frequently comorbid with mood, anxiety, and psychotic disorders, and they commonly present in tandem in both primary care and psychiatric settings. Unfortunately, in the past, individuals with co-occurring substance use and mental health disorders would receive treatment in community mental health clinics only after their substance use disorder was “stabilized.” There has been increasing recognition that integrated treatment is necessary for these individuals to fully succeed and achieve recovery. This chapter uses a common presentation to illustrate up-to-date scre
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6

Modir, Shahla J., and John Tsuang. Psychiatric Assessment and Co-Occurring Disorders. Edited by Shahla J. Modir and George E. Muñoz. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190275334.003.0012.

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This chapter on co-occurring disorders examines issues pertaining to substance-use disorder and psychiatric illnesses. It takes a very close look at prevalence, diagnoses, and medication treatment strategies for both psychiatric disorders, as well as for substance-use disorders. The chapter puts special emphasis on psychiatric disorders such as depression, bipolar disorder, anxiety, psychosis, and attention deficit hyperactivity disorder. Complementary treatment tools such as use of various vitamins, fish oil, and other natural chemical agents are reviewed here as well. Finally, alternative th
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7

Guerdjikova, Anna I., Paul E. Keck, and Susan L. McElroy. The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0018.

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Bipolar disorder (BD) commonly co-occurs with attention deficit hyperactivity disorder (ADHD) and eating disorders (EDs) in adolescents and in adults. The aim of this chapter is to summarize the available data regarding prevalence, clinical presentation, and psychological and pharmacological treatment of such complicated cases. Results of randomized controlled and open-label trials and case reports are reviewed. The main therapeutic goal when treating BD co-morbid with ADHD or ED is selecting a treatment strategy effective in the management of both syndromes, or at the minimum, selecting one t
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8

Tracy, Derek K., and Fiona Gaughran. Treatment with medication: Side effects, adherence, and risk. Edited by Alec Buchanan and Lisa Wootton. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198738664.003.0009.

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Antipsychotic medications revolutionized the care of psychosis, but they have brought with them significant side effects and issues around adherence; these latter factors, and informed co-working with patients, are primary drivers for specific medication choices. The data remain limited for polypharmacy and above-maximum dose prescribing, though there may be individuals for whom this is considered. Long-acting injectables (LAIs or ‘depots’) have a good evidence base, and are probably underutilized, though clozapine remains our drug of choice in refractory illness. Forensic-population data show
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9

Miller, Mark D. Overview of Late-Life Depression. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780195382242.003.0005.

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Chapter 4 outlines late-life depression. It explores the causes of depression (including medical conditions, medication, and alcohol), treatments for depression, and other diagnoses (bipolar disorder, co-occuring anxiety, and personality disorders), depression and cognitive impairment, and collaborative care.
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10

Hazelden Co Occurring Disorders Program Medication Management Curriculum 4: Integrated Services for Substance Use and Mental Health Problems Developed by Faculty from the Dartmouth Medical School. Hazelden Publishing, 2008.

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11

Al-Darraji, Haider A., and Frederick L. Altice. The Perfect Storm. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199374847.003.0008.

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Globally, tuberculosis (TB) is a major cause of morbidity and mortality among people who use drugs (PWUD), particularly those co-infected with HIV. This chapter describes how TB is prevalent in several prison systems by virtue of the concentration of PWUD and people living with HIV. TB is further amplified within this system through overcrowding, poor ventilation, and delayed access to quality prevention and treatment services. In many countries, individuals cycling through prisons are inadequately screened and treated for TB, and affected individuals may have frequent treatment interruptions.
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12

Zaiwalla, Zenobia, and Roo Killick. Polysomnography and other investigations for sleep disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0016.

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This chapter describes the key investigations used in the diagnosis of sleep disorders. The recording and value of polysomnography (PSG), with and without electroencephalography is discussed, including the specific parameters essential for the various sleep related breathing disorders. The technical aspects of the multiple sleep latency test and maintenance of wakefulness test are followed by interpretation of findings, recognizing their limitations, especially in adults with co-morbid disorders, and the effect of medication and also shift work. Finally, the value of wrist actigraphy as a diag
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13

Walton, Katherine E., and Sally Ager. Antimicrobial agents. Edited by Rob Pickard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0002.

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Antimicrobial resistance is a growing problem, which can be exacerbated by inappropriate use of antimicrobial agents. An understanding of the judicious use of antimicrobial agents, also known as antimicrobial stewardship, is therefore of fundamental importance to safe clinical practice. Patient factors should also be considered, including age, clinical status, special factors such as pregnancy or immunosuppression, co-morbidities, allergies, medication which may result in potential drug interactions, previous microbiology results, and antimicrobial treatment history. Important antimicrobial ch
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14

Cohen, Stacy A., Margaret M. Haglund, and Larissa J. Mooney. Treatment Options for Older Adults with Substance-Use Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199392063.003.0010.

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Due to co-occurring medical disorders, psychosocial differences, functional and cognitive limitations related to aging, and the potential for multiple medication interactions, unique considerations must be made when addressing the diagnosis and treatment of SUDs among the elderly. Better information is needed on all fronts, from initial screening and assessment, to triaging to appropriate levels of care, to behavioral therapies and pharmacological treatment. Guidelines should help direct providers, families, and patients identify appropriate and individualized treatment programs. Encouragingly
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15

Kissane, David W., and Matthew Doolittle. Depression, demoralization, and suicidality. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0173.

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The development of clinical depression is common during palliative care, adversely affects quality of life and adherence to medical treatments, yet regrettably can pass unrecognized. Screening for distress as the sixth vital sign is therefore highly recommended. Demoralization is another form of distress where the apparent pointlessness of continued life may lead to suicidal thinking. As the mental condition deteriorates, co-morbid states of anxiety, depression, and demoralization become more likely. Rates of suicide are increased with advanced cancer and poor symptom control. Fortunately, com
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16

Pickering, Gisèle. Pain in later life. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198785750.003.0040.

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The population of Europe is ageing, caused by fewer births and increased longevity. Increasingly the demand for pain assessment and treatment will change and the patients requesting help will present with more complex demands. In this chapter of European Pain Management we focus on the need for translational research, evidence-based randomized clinical trials, and non-pharmacological approaches in older persons, to assess the real-life risk/benefit ratio of recommendations in a context of multiple medication, co-morbidity, cognitive impairment, and frailty. It is essential to study the cogniti
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17

Dening, Tom, and Alisoun Milne. Care homes for older people. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0027.

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Although only 5% of the total over 65 population in developed countries lives in a care home, the lifetime risk of needing residential care is considerable. In the UK, 418 000 older people occupy nearly 12 000 care homes; the sector has a total value of around £14 billion. Care home residents tend to be very old, most are women, and most have complex co-morbid needs. Most people enter a care home because they can no longer live independently due to ill health, notably dementia. Dementia affects over two thirds of all residents; physical disability and functional impairment are also common. Beh
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18

Miskowiak, Kamilla W., and Lars V. Kessing. Cognitive enhancement in bipolar disorder: current evidence and methodological considerations. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0026.

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Cognitive dysfunction is an emerging treatment target in bipolar disorder (BD). Numerous trials have assessed the efficacy of novel pharmacological and psychological treatments on cognition. Overall, the results are disappointing, possibly due to methodological challenges. A key issue is the lack of consensus on whether and how to screen for cognitive impairment and on how to assess efficacy. We suggest that screening for cognitive impairment is critical and should involve objective neuropsychological tests. We also recommend that the primary outcome is a composite of neuropsychological tests
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19

Grant, Robert. Neurocutaneous syndromes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0235.

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This chapter describes several neurocutaneous syndromes, including tuberous sclerosis, neurofibromatosis, Sturge–Weber syndrome, Von-Hippel–Lindau disease and ataxia telangiectasia amongst others.Tuberous sclerosis, also known as Epiloia or Bournville’s Disease, is an autosomal dominant multisystem disease it usually presents in childhood with a characteristic facial rash, adenoma sebaceum, seizures, and sometimes learning difficulties. Central nervous system lesions in tuberous sclerosis are due to a developmental disorder of neurogenesis and neuronal migration. Other organs such as the heart
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