Relevant bibliographies by topics / Coating of pellets

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Academic literature on the topic 'Coating of pellets'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Coating of pellets"

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Varshosaz, Jaleh, Jaber Emami, Naser Tavakoli, Mohsen Minaiyan, Nakisa Rahmani, Farid Dorkoosh, and Parvin Mahzouni. "Colon specific delivery of budesonide based on triple coated pellets: in vitro/in vivo evaluation." Acta Pharmaceutica 62, no. 3 (September 1, 2012): 341–56. http://dx.doi.org/10.2478/v10007-012-0025-y.

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Three layered pellets of budesonide were prepared for colon delivery by the extrusion-spheronization method. The coatings consisted of hydroxypropylmethyl cellulose (HPMC) (as barrier layer), Eudragit E (as rate controlling layer) and hydroxypropylmethyl cellulose acetate succinate (HPMC AS) (as enteric layer). The rate controlling layer was further modified using various pore formers. Dissolution studies were carried out at pH 1.2, 7.4 and 6.8. Pellet core composition and type and level of pore former affected the drug release from pellets. Pellets containing 20 % (m/m) citric acid in the cores coated with HPMC at a coating level of 6 % (m/m), Eudragit E containing Avicel RC 581 (30 %) as pore former at a coating level of 30 % (m/m) and HPMC AS at a coating level of 15 % (m/m) had the best release profiles. These pellets showed promising results in alleviating the conditions of an experimental model of colitis induced by trinitrobenzenesulfonic acid in rats.
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Patil, Arun Trambak, Deepak Shamrao Khobragade, Sandip Annaji Chafle, Amol Prasadrao Ujjainkar, Sudhir Niranjanrao Umathe, and Champalal Laxminarayan Lakhotia. "Development and evaluation of a hot-melt coating technique for enteric coating." Brazilian Journal of Pharmaceutical Sciences 48, no. 1 (March 2012): 69–77. http://dx.doi.org/10.1590/s1984-82502012000100008.

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Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric hot-melt coating materials. HMC was carried out in a specially modified coating pan by applying SA and PA in molten state onto preheated pellets to achieve a coating level of 5-15 %w/w. Hot-melt coated pellets were evaluated for disintegration pH and in vitro dissolution in the pH range 1.2 to 6.8, along with basic micromeritics. SEM of coated pellets showed a uniform and smooth coating. These results indicated that HMC of both SA and PA exhibited very good enteric coating ability. The coated pellets showed negligible drug release in acidic pH. As the pellets were subsequently transferred to a higher pH level, a gradual increase in release of the drug from the pellets was observed with increasing pH of the dissolution media. The release was dependent upon coating extent, providing sustained enteric release as opposed to abrupt release with mixed release kinetics.
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Barmpalexis, Panagiotis, Ioannis Partheniadis, Konstantina-Sepfora Mitra, Miltiadis Toskas, Labrini Papadopoulou, and Ioannis Nikolakakis. "Application of Multiple Linear Regression and Artificial Neural Networks for the Prediction of the Packing and Capsule Filling Performance of Coated and Plain Pellets Differing in Density and Size." Pharmaceutics 12, no. 3 (March 8, 2020): 244. http://dx.doi.org/10.3390/pharmaceutics12030244.

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Plain or coated pellets of different densities 1.45, 2.53, and 3.61 g/cc in two size ranges, small (380–550 μm) and large (700–1200 μm) (stereoscope/image analysis), were prepared according to experimental design using extrusion/spheronization. Multiple linear regression (MLR) and artificial neural networks (ANNs) were used to predict packing indices and capsule filling performance from the “apparent” pellet density (helium pycnometry). The dynamic packing of the pellets in tapped volumetric glass cylinders was evaluated using Kawakita’s parameter a and the angle of internal flow θ. The capsule filling was evaluated as maximum fill weight (CFW) and fill weight variation (FWV) using a semi-automatic machine that simulated filling with vibrating plate systems. The pellet density influenced the packing parameters a and θ as the main effect and the CFW and FWV as statistical interactions with the coating. The pellet size and coating also displayed interacting effects on CFW, FWV, and θ. After coating, both small and large pellets behaved the same, demonstrating smooth filling and a low fill weight variation. Furthermore, none of the packing indices could predict the fill weight variation for the studied pellets, suggesting that the filling and packing of capsules with free-flowing pellets is influenced by details that were not accounted for in the tapping experiments. A prediction could be made by the application of MLR and ANNs. The former gave good predictions for the bulk/tap densities, θ, CFW, and FWV (R-squared of experimental vs. theoretical data >0.951). A comparison of the fitting models showed that a feed-forward backpropagation ANN model with six hidden units was superior to MLR in generalizing ability and prediction accuracy. The simplification of the ANN via magnitude-based pruning (MBP) and optimal brain damage (OBD), showed good data fitting, and therefore the derived ANN model can be simplified while maintaining predictability. These findings emphasize the importance of pellet density in the overall capsule filling process and the necessity to implement MLR/ANN into the development of pellet capsule filling operations.
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Patel, Hetal, and Mukesh Gohel. "A Review on Enteric Coated Pellets Composed of Core Pellets Prepared by Extrusion-Spheronization." Recent Patents on Drug Delivery & Formulation 13, no. 2 (August 29, 2019): 83–90. http://dx.doi.org/10.2174/1872211313666190212115139.

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Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibit less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-spheronization technique and the enteric coating is applied in a fluidized bed processor. Two approaches are involved in the preparation of core pellets. In the first approach, a mixture of drug and excipient(s)/co-processed excipient is passed through extruders to prepare core pellets. In the second approach, excipient core pellets are prepared by extrusion technique and the drug is layered onto it before the enteric coating. The excipients present in the core pellets decide immediate or extended release of drug in the intestine. The coprocessed excipient pellets provide less batch variability and provide a platform for layering of many drugs before enteric coating. Some patents included enteric coating pellets [CN105456223 (A), CN105596310 (A), CN105616371 (A), CN105663095 (A), CN101611766B, CN106511862 (A), CN106668018 (A), CN106727381 (A), CN106924222 (A), TW200624127 (A), US 2017/0165248A1, US 2017/0224720A1] are discussed.
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Patel, Sandipkumar A., Nrupa G. Patel, and Abhijeet B. Joshi. "MULTIPLE UNIT PELLET SYSTEM (MUPS) BASED FAST DISINTEGRATING DELAYED-RELEASE TABLETS FOR PANTOPRAZOLE DELIVERY." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 1 (January 1, 2018): 77. http://dx.doi.org/10.22159/ijpps.2018v10i1.21443.

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Objective: The rationale for the study was to develop multiple unit pellet system (MUPS) of delayed release pantoprazole with desired physical properties and unaltered drug release profile from pellets even after compression into a fast disintegrating tablet.Methods: In the presented study, delayed release pellets of pantoprazole were developed by two methods, i.e. extrusion-spheronization and drug layering techniques, coated using enteric polymer and subsequently compressed in to tablet. In drug layering technique, pantoprazole was loaded on Celphere®102 (microcrystalline cellulose spheres) as well as on Suglet® (sugar spheres) in fluid bed processor. Acid resistant polymer Eudragit ND 30D was subsequently coated on each type of drug loaded pellets. Suitable tableting excipients were prepared such as soft pellets, Ceolus® (fibrous grade of microcrystalline cellulose) granules, Ludipress® (compressible lactose composition), Avicel® PH 200 and different combination of them. Various factors like property of pellets to be compressed, coating level, the composition of tableting excipient and ratio of drug-loaded pellets to tableting excipients were identified and optimized.Results: MUPS with delayed releasing pellets of pantoprazole proved to provide sufficient hardness, rapid disintegration property, and unaltered release profile after compression. Delayed release pantoprazole pellets prepared by drug layering on celphere® 102 followed by coating with Eudragit® NE 30D showed better compressibility to withstand the drug release properties. The combination of Ceolus® granules and Ludipress (in 1:1 ratio) was found to be suitable tableting excipient that helped compression of pellets without rupturing polymeric coat. Pellets to excipients ratio at 1:3 was found optimum.Conclusion: Compaction behaviour of pantoprazole delayed-release pellets without loss of original delayed release profile was achieved by formulating as MUPS based tablet of pantoprazole delayed release pellets using celephere® 102 was developed which was found suitable for desired release profile and physical properties.
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Motas, Justina G., Nima E. Gorji, Dumitru Nedelcu, Dermot Brabazon, and Fabrizio Quadrini. "XPS, SEM, DSC and Nanoindentation Characterization of Silver Nanoparticle-Coated Biopolymer Pellets." Applied Sciences 11, no. 16 (August 21, 2021): 7706. http://dx.doi.org/10.3390/app11167706.

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The development of environmentally friendly materials has been the focus of many research groups in recent years due to increased harmful effects of plastics on the environment. Bio-based materials are considered a key solution from a sustainable manufacturing perspective. The nano-coating of biopolymer blends with silver nanoparticles is the subject of challenging research projects in line with the EU Directive on environment protection and sustainable manufacturing. Coating biopolymers with silver nanoparticles provides an antimicrobial and antiviral active surface. In this work, we develop silver nanoparticle-coated biopolymer Arboblend V2 Nature pellets. The main goal is to obtain a new material with antibacterial action obtained from the blending of a biopolymer pellets with silver nanoparticles through physical vapor deposition. The study is divided in three steps. The first step represents the silver nano-coating of the Arboblend V2 Nature and the characterization of the coated/raw pellets. The second step involves the injection molding of the silver nano-coated pellets and the characterization of the samples obtained. The last step regards the press molding of the coated pellets in order to obtain thin films, as well as their characterization. The PVD-sputtering technique is used to coat the pellets with silver nanoparticles. This process is especially optimized for coating raw materials with high water content and small-size pellets. The mechanical properties, surface chemical composition and the thermal properties of the both virgin and silver nanoparticle-coated biopolymer pellets are measured and analyzed for mechanical and thermal resistance of the nano-coating layer. Differential scanning calorimetry, scanning electron microscopy, X-ray photoemission spectroscopy and nanoindentation mechanical testing is performed. The calorimetry test detects no significant alteration of the biopolymer produced from the PVD process and confirms the optimized PVD process for nano-coating of the Arboblend V2 Nature pellets with a viable application in nano-silver–biopolymer composite products.
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Wan, Dongwei, Min Zhao, Jingjing Zhang, and Libiao Luan. "Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer." Pharmaceutics 11, no. 6 (June 5, 2019): 260. http://dx.doi.org/10.3390/pharmaceutics11060260.

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This study aimed to develop a novel sustained release pellet of loxoprofen sodium (LXP) by coating a dissolution-rate controlling sub-layer containing hydroxypropyl methyl cellulose (HPMC) and citric acid, and a second diffusion-rate controlling layer containing aqueous dispersion of ethyl cellulose (ADEC) on the surface of a LXP conventional pellet, and to compare its performance in vivo with an immediate release tablet (Loxinon®). A three-level, three-factor Box-Behnken design and the response surface model (RSM) were used to investigate and optimize the effects of the citric acid content in the sub-layer, the sub-layer coating level, and the outer ADEC coating level on the in vitro release profiles of LXP sustained release pellets. The pharmacokinetic studies of the optimal sustained release pellets were performed in fasted beagle dogs using an immediate release tablet as a reference. The results illustrated that both the citric acid (CA) and ADEC as the dissolution- and diffusion-rate controlling materials significantly decreased the drug release rate. The optimal formulation showed a pH-independent drug release in media at pH above 4.5 and a slightly slow release in acid medium. The pharmacokinetic studies revealed that a more stable and prolonged plasma drug concentration profile of the optimal pellets was achieved, with a relative bioavaibility of 87.16% compared with the conventional tablets. This article provided a novel concept of two-step control of the release rate of LXP, which showed a sustained release both in vitro and in vivo.
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de Souza, Luciane Franquelin Gomes, Marcello Nitz, and Osvaldir Pereira Taranto. "Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/520758.

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The objective of this work was to study the coating process of nifedipine extended release pellets using Opadry and Opadry II, in a fluid bed coater with a Wurster insert. The coating process was studied using a complete experimental design of two factors at two levels for each polymer. The variables studied were the inlet air temperature and the coating suspension flow rate. The agglomerate fraction and coating efficiency were the analyzed response variables. The air temperature was the variable that most influenced the coating efficiency for both polymers. In addition, a study of the dissolution profiles of coated and uncoated pellets using 0.5% sodium lauryl sulfate in simulated gastric fluid without enzymes (pH 1.2) was conducted. The results showed a prolonged release profile for the coated and uncoated pellets that was very similar to the standards established by the U.S. Pharmacopoeia. The drug content and the release profiles were not significantly affected by storage at 40°C and 75% relative humidity. However, when exposed to direct sunlight and fluorescent light (light from fluorescent bulbs), the coated pellets lost only 5% of the drug content, while the uncoated ones lost more than 35%; furthermore, the dissolution profile of the uncoated pellets was faster.
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Freire, Fátima Duarte, Manuela Bernardo Câmara, Monique Gomes Dantas, Cícero Flávio Soares Aragão, Túlio Flávio Accioly de Lima e Moura, and Fernanda Nervo Raffin. "Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium." Brazilian Journal of Pharmaceutical Sciences 50, no. 4 (December 2014): 749–55. http://dx.doi.org/10.1590/s1984-82502014000400010.

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Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets were obtained to physical contact of this drug with rifampicin and to bypass the stomach´s acidic environment. The pellets were fabricated using the extrusion-spheronization technique. The coating process was conducted in a fluid spray coater using Acrycoat L 100(r) solution as the coating agent. The pellets obtained were submitted to a dissolution test in HCl 0.1 N and phosphate buffer media. The results indicated that optimum gastric-resistance was only attained with the highest amount of coating material, with isoniazid almost fully released in phosphate buffer. The amount of rifampicin released from its mixture with non-coated isoniazid pellets in HCl 0.1 N was less than that released from its mixture with the enteric-coated pellets. Acrycoat L 100(r) was shown to be an effective enteric/gastric-resistant coating since the stability of rifampicin appeared to be enhanced when physical contact of this drug with isoniazid was prevented at low pH.
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Theismann, Eva-Maria, Julia K. Keppler, Martin Owen, Karin Schwarz, and Walkiria Schlindwein. "Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach." Pharmaceutics 11, no. 4 (April 1, 2019): 154. http://dx.doi.org/10.3390/pharmaceutics11040154.

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The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of the extrusion-spheronisation process on the roundness, roughness and useable yield of the obtained pellets. The obtained results were compared to spray granulated NAM particles regarding their characteristics and their release profile in vitro after the application of an ileocolon targeted shellac coating. The wet extrusion-spheronisation process was able to form highly loaded NAM pellets (80%) with a spherical shape and a high useable yield of about 90%. However, the water content range was rather narrow between 24.7% and 21.3%. The design of experiments (DoE), showed that the spheronisation conditions speed, time and load had a greater impact on the quality attributes of the pellets than the extrusion conditions screw design, screw speed and solid feed rate (hopper speed). The best results were obtained using a low load (15 g) combined with a high rotation speed (900 m/min) and a low time (3–3.5 min). In comparison to spray granulated NAM pellets, the extruded NAM pellets resulted in a higher roughness and a higher useable yield (63% vs. 92%). Finally, the coating and dissolution test showed that the extruded and spheronised pellets are also suitable for a protective coating with an ileocolonic release profile. Due to its lower specific surface area, the required shellac concentration could be reduced while maintaining the release profile.
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Dissertations / Theses on the topic "Coating of pellets"

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Sterneland, Jerker. "Some aspects on the reduction of olivine pellets in laboratory scale and in an experimental blast furnace." Doctoral thesis, KTH, Materials Science and Engineering, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3381.

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The reduction behaviour of the olivine iron ore pellet MPBOwas studied in laboratory scale at KTH as well as in the LKABexperimental blast furnace. Initially, a newreduction-under-load, or so-called reduction/softening/melting,test equipment was developed. Experiments using differentreducing conditions, corresponding to different radialpositions of the blast furnace, were conducted. The experimentsincluded different temperature profiles, reducing atmospheresand mechanical loads applied on the sample bed to simulate thevarying conditions in the blast furnace process. The progressof reduction was investigated, as well as the processes ofsintering and contraction during reduction. A model of thecarburisation (pick-up of carbon by the reduced iron) andmelt-down process during rapid contraction was presented.

Laboratory testing of MPBO pellets was compared with resultsfrom the LKAB experimental blast furnace. The reduction of ironore pellets in the experimental blast furnace was surveyed by adissection of the furnace after quenching. The high temperaturephenomena occurring when reducing the MPBO pellet, with limitedsoftening and a short temperature range of the melting process,resulting in a thin cohesive zone, were found to be the same inlaboratorytests and in the experimental blast furnace. Thereduction down through the burden of the experimental blastfurnace was similar, but not identical to the results of theRUL experiments. The differences were found to be due todifferent reducing conditions. Therefore, it was concluded thata simulation of the reduction occurring in the blast furnacecan be performed in laboratory scale, provided the experimentalconditions are correctly chosen.

Finally, a modification to further improve the properties ofthe MPBO pellets was examined. With the aim to improve theblast furnace process, coating of blast furnace pellets wasinvestigated in laboratory scale, as well as in the LKABexperimental blast furnace. Olivine, dolomite and quartzitewere used as coating agents. In laboratory scale the stickingprevention action of the different coating materials wasverified, in established test methods as well as in new testmethods, modified for blast furnace conditions. Testing of thecoated pellets in the experimental blast furnace revealedseveral advantages; significantly reduced blast furnace fluedust generation, improved gas utilisation and a smoother blastfurnace operation with a potential for a lowered fuel rate.

Keywords:Olivine, pellets, pellet testing,reduction/softening/melting, MPBO, blast furnace, reduction,quenching, dissection, coating, sticking, coated pellets.

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Larsen, Crilles Casper. "Process control and evaluation of aqueous latex film coating of pellets in fluidised bed /." Cph. : The Danish University of Pharmaceutical Sciences, department of Pharmaceutics, 2004. http://www.dfh.dk/phd/defences/crillescasperlarsen.htm.

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Melegari, Cecilia <1985&gt. "Study of Different Technologies for Film Coating of Drug Layered Pellets Using Ethylcellulose as Functional Polymer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7487/.

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The research project focused on the study of different technologies for film coating of pellets using ethylcellulose as barrier-membrane coating polymer. In particular, two different approaches were investigated: the conventional aqueous film coating and the dry powder coating methods. The research carried out during the first part of the PhD provided a comprehensive study of the conventional aqueous film coating process of guaifenesin-loaded pellets in order to understand the variables affecting the drug migration through the barrier-membrane film coating and thus the stability over time of the final dosage form. The analysed process comprised the drug layering followed by the film coating technique in a Wurster fluid bed. The effect of curing conditions, drug loading and coating level and of the drug-layering solution on the technological properties of pellets was fully evaluated. In the second part of the research, an innovative dry powder coating technology was developed to apply the functional ethylcellulose based coating upon pellets avoiding the use of solvents (neither organic solvents nor water). In particular, the study was designed along three steps: i) Preparation of free films to evaluate the film formation process and to achieve the minimum film forming temperature of the coating formula; ii) Powder coating process of unloaded pellets; iii) Powder coating of drug-loaded pellets. This research analyzed different combinations of polymer, plasticizer, co-plasticizer and other adjuvant by evaluating free films and their assessment through curing and storage. Then suitable coating formulations were utilized for the development of the manufacturing process upon placebo pellets. Subsequently, the dry powder coating process was successfully optimized to coat caffeine-loaded pellets.
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Ryösä, Elin. "Mineral Reactions and Slag Formation During Reduction of Olivine Blast Furnace Pellets." Doctoral thesis, Uppsala universitet, Institutionen för geovetenskaper, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9389.

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The present work focuses on mineral reactions and slag formation of LKAB olivine iron ore pellets (MPBO) subjected to reducing conditions in the LKAB experimental blast furnace (EBF). The emphasis is on olivine reactions with surrounding iron oxides. Many factors influence the olivine behaviour. The study was performed by use of micro methods; optical microscopy, micro probe analysis, micro Raman and Mössbuer spectroscopy and thremodynamic modeling. During manufacturing, in oxidising atmosphere at high temperature (1350°C), olivine alterations occur through slag formation and rim reactions with iron oxides and other additives. To be able to describe olivine behaviour in the rather complex blast furnace reduction process one has to consider factors such as reactions kinetics, reduction degree of iron oxides, vertical and horizontal position in the furnace and reactions with alkali. Samples were collected from the EBF both from in shaft probing during operation and from excavation following quenching of the EBF. The initial slag forming olivine consist of primary forsterite – (Mg1.9Fe0.1)SiO4 – with inclusions of hematite and an amorphous silica rich phase, a first corona with lamellae of magnesioferrite, olivine and orthopyroxene, a second corona of amorphous silica and magnesioferrite. During reduction in the upper shaft in the EBF (700-900°C) Fe3+ reduces to Fe2+. The amorphous silica in the second corona absorbs alkali, Al, Fe2+, Mg, and Ca and form glasses of varying compositions. The lamellae in the first corona will merge into a single phase olivine rim. With further reduction the glasses in the second corona will merge with the olivine rim forming an iron rich olivine rim and leaving the elements that do not fit into the olivine crystal lattice as small silicate glass inclusions. Diffusion of magnesium and iron between olivines and iron oxides increase with increasing temperature in the lower shaft of the EBF (750-1100°C). In the cohesive zone of the EBF (1100-1200°C) Fe2+ is not stable any longer and Fe2+ will be expelled from the olivine as metallic iron blebs, and the olivine will form a complex melt with a typical composition of alkali-Al2O3-MgO-SiO2. Alkali plays an important role in this final olivine consumption. The quench time for samples collected with probes and excavation are minutes respectively hours. A study of the quench rate’s effect on the phases showed no differences in the upper shaft. However, in the lower shaft wüstite separates into wüstite and magnetite when wüstite grows out of its stability field during slow cooling of excavated samples. There is also a higher alkali and aluminium deposition in the glass phases surrounding olivines in excavated pellets as a result of alkali and aluminium gas condensing on the burden in the EBF during cooling. Coating applied to olivine pellets was studied in the EBF with the aim to investigate its behaviour, particularly its ability to capture alkali. The coating materials were kaolinite, bauxite, olivine and limestone. No significant reactions were observed in the upper shaft. In the lower shaft a majority of the phases were amorphous and reflecting the original coating compositions. Deposition from the EBF gas phase occurs and kalsilite (KAlSiO4) is found in all samples; coating used for binding alkali is redundant from a quality perspective.
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Kumpugdee, Mont. "Coating of pellets with aqueous dispersions of enteric polymer by using a Wurster-based fluidized bed apparatus Überziehen von Pellets mit wässrigen, magensaftresistenten Polymerdispersionen in der Wirbelschichtanlage /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965641074.

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Albanez, Roberta. "Recobrimento gastrorresistente de pellets de diclofenaco de sódio em leito fluidizado tipo Wurster." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266823.

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Orientadores: Osvaldir Pereira Taranto, Marcello Nitz
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química
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Resumo: Os pellets apresentam muitas vantagens biofarmacêuticas e são ideais para aplicação de recobrimento. Quando o recobrimento é funcional, um dos principais objetivos é formação de uma barreira que modifique o perfil de liberação da droga (liberação controlada ou gastrorresistente). Neste trabalho pellets de diclofenaco de sódio foram produzidos por extrusão/esferonização e, em seguida, foram recobertos em leito fluidizado tipo Wurster. Esse tipo de leito é um dos sistemas mais adequados para o recobrimento de partículas. Dentre suas vantagens destaca-se a não formação de zonas mortas. Este trabalho teve como objetivo estudar o recobrimento dos pellets produzidos com duas suspensões poliméricas aquosas comerciais entéricas, Advantia® Performance e Acryl-Eze® MP. O estudo do processo de recobrimento foi realizado por meio de um planejamento experimental 2³. As variáveis estudadas foram: temperatura do ar de entrada, vazão da suspensão e polímero de recobrimento. As variáveis de resposta foram: eficiência do processo, resultados acima de 78,2%, e fração de aglomerados, resultados inferiores a 8%. O efeito do tipo de polímero de recobrimento foi o que mais influenciou as variáveis de resposta, sendo que o Advantia® Performance resultou numa maior eficiência e uma maior fração de aglomerados. Determinou-se também o ganho de massa mínimo para atingir a gastrorresistência - Acryl-Eze® MP: 9,7% e Advantia® Performance: 8,6%. Os pellets revestidos passaram por testes de teor, dissolução e estabilidade. No teste de estabilidade os pellets recobertos com Advantia® Performance mantiveram seu perfil gastrorresistente. Porém, os pellets recobertos com Acryl-Eze® MP apresentaram um aumento da gastrorresistência após a exposição às condições de estabilidade, o que pode indicar que a coalescência das partículas do polímero aconteceu durante a estocagem. As suspensões foram caracterizadas quanto à sua reologia e ângulo de contato. O tempo de instantaneização do pó polimérico também foi testado
Abstract: Pellets have many biopharmaceutical advantages and are suitable for coating. When the coating is performed for functional purpose, one of the major goal is to form a barrier that modifies the drug release profile (controlled or enteric release). In this work, diclofenac sodium pellets were produced by the extrusion / spheronisation process and then coated in a fluidized bed coater column with a Wurster insert. This type of bed is one of the best suited systems for the coating of particles. One of the main advantages is that it avoids dead zones. This work aimed to study the coating of pellets produced with two commercial aqueous enteric polymer suspensions, Advantia® Performance and Acryl-Eze® MP. The study of the coating process was accomplished through a 2³ experimental design. The variables studied were: inlet air temperature, suspension flow rate and coating polymer. The response variables were: process efficiency, results above 78.2%, and agglomeration fraction, values below 8%. The effect of polymer coating type was the variable that influenced the response variables the most. The polymer Advantia ® Performance resulted in a better efficiency and increased the agglomerate fraction. The minimum mass gain to achieve the enteric profile was also determined - Acryl-Eze® MP: 9.7% and Advantia® Performance: 8.6%. The coated pellets were tested for content, dissolution and stability. In the stability test, pellets coated with Advantia® Performance maintained the enteric profile. However, the pellets coated with Acryl-Eze® MP presented a better enteric profile after the exposure to conditions of stability, which may indicate that coalescence of the polymer particles occurred during storage. The suspensions were characterized by rheology and contact angle. The static wettability of the polymeric powder was also tested
Mestrado
Engenharia de Processos
Mestre em Engenharia Química
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Alencar, Rodrigo Gomes de. "Desenvolvimento de comprimidos contendo pellets revestidos para liberação cólon específica de cetoprofeno." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4020.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Ketoprofen is a nonsteroidal anti-inflammatory drug used for the treatment of mild to moderate pain in chronic inflammatory conditions. Due to its superior potency ketoprofen can be used in the treatment of inflammatory bowel disease (IBD). The treatment of IBD becomes safer and more effective when the drug is incorporated into colon-specific drug delivery systems. Pellets are multiparticulate solid dosage forms extensively investigated as colon-specific drug delivery systems. Pellets can be introduced into capsules or compressed into tablets. The industrial production of tablets containing pellets has several advantages when compared to the production of capsules. However, the compression of the pellets should not affect the release of the drug and the tablets should quickly disintegrate following administration. Therefore, the aim of this study was to develop tablets containing ketoprofen coated pellets for colon-specific drug release. For this, pellets were produced by extrusion and spheronization technique containing 40% (w / w) ketoprofen. Ketoprofen pellets obtained were coated with two different pH - dependent polymers derived from methacrylic acid (Opadry ® k 94 or Eudragit ® FS 30D) with weight gains of 10 or 20% (w / w). The coated pellets were then compressed under different pellets’ amounts and different compression forces. An extra- granular mixture of lactose and microcrystalline cellulose was used as compression aid. The in vitro release of ketoprofen from the systems obtained was evaluated in Bio Dis ® apparatus. The morphological and physical properties of pellets and tablets were assessed. The Eudragit ® FS 30 D coated pellets with weight gains of 10 or 20% showed higher efficiency of colon-specific delivery (94 %), however, the drug was released slowly and incompletely in conditions mimicking the pH of the colonic region. After compression of the pellets, the efficiency of colon – specific drug delivery was lowered after compression (between 20% and 61%, depending on the formulation). The lowest decrease of colon specific efficiency was observed in formulations containing lower amount of pellets, which also produced disintegrating matrices with potential for use in the topical treatment of IBD.
O cetoprofeno é um antiinflamatório não esteroidal usado para o tratamento de dores leves a moderadas, em condições inflamatórias crônicas. Devido a sua elevada potência antiinflamatória, o cetoprofeno pode ser aproveitado no tratamento das doenças inflamatórias intestinais (DII). O tratamento das DII se torna mais seguro e eficaz quando o fármaco é incorporado em sistemas de liberação cólon-específica. Pellets são formas farmacêuticas multiparticuladas bastante investigadas como sistemas de liberação cólon-específica. Após sua produção, os pellets podem ser inseridos em cápsulas ou comprimidos. A produção industrial de comprimidos contendo pellets apresenta inúmeras vantagens quando comparada ao processo de enchimento de cápsulas. No entanto, a compressão dos pellets não deve afetar as características de liberação do fármaco e os comprimidos formados devem se desintegrar rapidamente. Dessa forma, o objetivo deste trabalho foi desenvolver comprimidos contendo pellets revestidos para liberação cólon-específica de cetoprofeno. Para tanto, foram produzidos pellets contendo 40% (p/p) de cetoprofeno e celulose microcristalina pela técnica de extrusão e esferonização. Os pellets de cetoprofeno obtidos foram revestidos com dois diferentes polímeros pH-dependentes, ambos derivados do ácido metacrílico (Opadry ® 94 k ou Eudragit ® FS 30) com ganhos de massa 10 ou 20% (p/p). Os pellets revestidos foram então comprimidos com diferentes cargas de pellets e submetidos a diferentes forças de compressão, utilizando como adjuvante extra-pellets uma mistura granulada de lactose e celulose microcristalina. A liberação in vitro do cetoprofeno a partir das formas farmacêuticas obtidas foi avaliada em dissolutor Bio Dis aparato III. As caracterizações morfológicas e físicas dos pellets e comprimidos foram conduzidas. Os pellets obtidos por revestimento com Eudragit ® FS 30 D, com ganhos de massa de 10 ou 20%, mostraram elevada eficiência de liberação cólon-específica in vitro (até 94%), no entanto, o fármaco foi liberado de forma lenta e incompleta em meio com pH similar ao encontrado na região colônica. Após a compressão dos pellets, os valores de eficiência de liberação cólon-específica sofreram reduções entre 20% e 61%. A menor diminuição da eficiência de liberação cólon-específica foi observada nas formulações contendo a menor carga de pellets, as quais deram origem à matrizes desintegráveis com potencial para utilização no tratamento tópico das DII.
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Tunón, Åsa. "Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release." Doctoral thesis, Uppsala University, Department of Pharmacy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3411.

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The preparation of multiple unit tablets was investigated in this thesis with the intention of gaining a deeper understanding of some of the factors that influence the properties of such tablets.

Initially, three different types of pellets (drug, soft and disintegrant pellets) were combined as a model to investigate the ability of the mixture to form disintegrating tablets. The proportions of the different pellets and the type of disintegrant used were factors that independently influenced the tablet properties. Furthermore, the properties of tablets containing drug pellets barrier-coated with an aqueous polymer dispersion were also found to depend on the coating thickness and the compaction pressure.

When compacting pellets barrier-coated with a solvent-based polymer solution without incorporating excipient particles in the tablet formulation, a high pellet porosity was advantageous to preserve the original drug release profile, even though highly porous pellets became more densified and deformed than pellets of lower porosity.

The influence of the properties of excipient particles on the deformation of the reservoir pellets was also studied and, although the amount of flattening of the pellets was only slightly affected, changes in the pellet shape (irregularity) with alterations in the porosity and size of the excipient particles were more substantial. In contrast, the properties of the excipient particles did not affect the pellet densification.

The solvent-based coating used was able to adapt to the changes in volume and shape that the pellets underwent during compaction. The coating structure appears to be changed by compaction and it is proposed that the final structure of the coating is the net effect of two parallel processes, one reducing and one prolonging the transport time of the drug across the coating. Thus, the drug release could be maintained or even prolonged after compaction, despite extensive structural changes of the reservoir pellets.

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Lagôa, André de Oliveira [UNESP]. "Efeitos da peletização na plantabilidade e na qualidade fisiológica de sementes de milho superdoce armazenadas em câmara fria." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/96911.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
As sementes de milho superdoce possuem fino pericarpo e formato irregular dificultando a operação de semeadura. Em função disso, surge a possibilidade de utilizar o processo de peletização para facilitar a semeadura e obter estande uniforme sem a necessidade de desbaste de plantas. Embora essa técnica seja conhecida há muitos anos, pouco se estudou sobre o efeito desse procedimento na plantabilidade e na qualidade fisiológica de sementes de milho superdoce. Sendo assim, este trabalho teve como objetivo avaliar o efeito da peletização na qualidade fisiológica e na ocorrência de falhas e de sementes duplas. A qualidade fisiológica das sementes e péletes foi avaliada pelos testes de germinação, primeira contagem de germinação e teste de frio. Foram avaliados também alguns atributos físicos das sementes e dos péletes por meio dos testes de fragmentação, retenção de peneiras, massa de mil sementes e volume aparente. O recobrimento foi muito eficiente na redução das falhas e da ocorrência de sementes duplas, proporcionando resultados altamente satisfatórios para esses atributos. Não houve efeito do armazenamento no potencial fisiológico nem nos resultados do teste a frio para as sementes nuas. As sementes recobertas foram afetadas negativamente pela peletização a partir dos 90 dias de armazenamento. Durante esse período todos os lotes de sementes peletizadas apresentaram-se dentro do padrão de germinação exigido pelo Ministério da Agricultura Pecuária e Abastecimento, os resultados permitiram concluir que o revestimento melhora a plantabilidade das sementes afetando positivamente a eficiência do processo de semeadura
The supersweet corn seeds have thin pericarps and irregular shape difficulting the sowing operation. As a result, there is the possibility of using the pelleting process to facilitate the seeding and more uniform stand without the need of thinning plants. Although this technique has been known for many years, little has been studied on the effect of this procedure in plantability and in physiological quality of supersweet corn seeds. Thus, this study aimed to evaluate the effect of pelleting on the water content during the storage and the occurrence of double seeds and lack of seeds in the holes during the sowing test. The physiological quality of seeds and pellets was evaluated by germination, first germination and cold test. It also was evaluated other physical attributes of seeds and pellets by means of fragmentation tests, retention sieves, seed weight and apparent volume. The coating was very effective in reducing seed double faults and providing highly satisfactory results for these attributes. There was not effect of storage on physiological potential or in the results of the cold test for naked seeds. The coated seeds were negatively affected by the coating from 90 days of storage. During this period all batches of pelleted seeds were inside the physiological pattern required by the ministry of agriculture. The results showed that the coating improves plantability seeds positively affecting the efficiency of the seeding process. Based on the results it can be concluded that the coating improve seed plantability, positively affecting the efficiency of the seeding process
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Fahier, Julie. "Polymeric controlled release film coatings." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S025/document.

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Les mini-granules enrobées offrent un grand potentiel pour la libération contrôlée de médicament par voie orale. Cependant, les mécanismes de libération impliqués ne sont pas toujours élucidés et compris. Ainsi, l’impact de certains paramètres de formulation peut être surprenant. Par exemple, il a été démontré dans ce travail :- La libération du propranolol HCl à partir de mini-granules enrobées avec du Kollicoat SR est plus lente si les mini-granules sont composées de noyaux de sucre comparé à des noyaux de cellulose microcristalline (CMC).Généralement, la tendance inverse est observée, car les noyaux de sucre ont une activité osmotique attirant plus rapidement l’eau à l’intérieur du système et entrainant ainsi, une dissolution et diffusion de la substance active. Ce résultat inattendu est dû à une association de 2 phénomènes : (i) l’effet plastifiant dû au sucre sur le film de Kollicoat SR et (ii) la diminution de la solubilité de cette SA dans le milieu de dissolution en présence de sucre dissous.De plus, le Kollicoat SR 30 D [dispersion aqueuse de poly(vinyl pyrrolidone)] offre des possibilités intéressantes de formulation par sa haute flexibilité et ses propriétés mécaniques stables. En revanche, les mini-granules composées de noyaux de sucre ont tendance à gonfler de par le cumul de l’activité osmotique du noyau et de la SA jusqu’à l’apparition de « cracks », révélés par des images obtenues par micro tomographie à rayons X.- Lorsqu’on augmente la quantité en propranolol HCl dans le système, la cinétique de libération est augmentée, particulièrement avec les mini-granules composées de noyaux de CMC.L’opposé est souvent constaté car accroitre la quantité de SA nécessite un plus grand apport en eau afin de pouvoir tout dissoudre. Les mini-granules à base de CMC présentent probablement des « cracks » malgré un faible gonflement du système, et sont accentués par l’augmentation de la concentration en propranolol HCl.En conclusion, des nouvelles connaissances sur les mécanismes de libération à partir de mini-granules enrobées avec du Kollicoat SR ont été apportées et l’importance du type de SA et la nature du noyau composant le système ont été élucidées.- Dans une deuxième partie, des mini-granules enrobées avec un mélange de polymère (Aquacoat ECD et Eudragit NM 30 D) ont été formulées dans le but de libérer la diprophylline, SA modèle, par diffusion à travers le film de polymère et de pouvoir modéliser sa cinétique à partir de modèles mathématiques
Polymer coated pellets offer a great potential for control drug delivery system. Nevertheless, the underlying drug release mechanisms can be complex and are not fully understood. Thus, the impact of formulation parameters can be surprising. For example, it has been demonstrated during this thesis that:- The release of propranolol HCl was slower from sugar-based pellets coated with Kollicoat SR compared to microcrystalline cellulose (MCC)-based pellets.Generally, the opposite was observed because the sugar cores are osmotically active attracting more and more water into the system leading to a fast dissolution and diffusion of the drug, especially with high water-soluble drug. This unexpected result is due to a combination of two phenomena: (i) The plasticizing effect of sugar for the film coating and (ii) Decrease in drug solubility in the release medium due to the presence of co-dissolved sugar.In addition, Kollicoat SR 30 D [an aqueous dispersion of poly(vinyl acetate) also containing small amounts of poly(vinyl pyrrolidone) and sodium lauryl sulfate] is a very interesting polymer owing to its high flexibility and stable mechanical properties. However, sugar-based pellets tend to swell by the osmotic pressure created by the high water-soluble API and the sugar until crack formation, clearly visible on the images obtained by X-ray micro tomography.- Propranolol HCl release in phosphate buffer pH 7.4 increases by increasing the drug loading into the system, especially from MCC-based pellets.The opposite was often observed since the amount of water within the drug reservoir might not be sufficient to dissolve all drug. MCC-based pellets likely presented also cracks despite a low swelling of the system, accentuated by the increase of propranolol HCl concentration.To conclude, new insights on the underlying drug release mechanisms from Kollicoat SR coated pellets were provided. The importance of the type of drug and the nature of starter cores were elucidated.- In the second part, diprophylline loaded pellets coated with a polymer blend composed of Aquacoat ECD and Eudragit NM were prepared in order to control the drug release only by diffusion through the intact polymeric film and to predict the drug kinetics using mathematical models
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Book chapters on the topic "Coating of pellets"

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Grave, Annette, and Norbert Pöllinger. "GLATT Wirbelschichttechnologie zum Coating von Pulvern, Pellets und Mikropellets." In Easy Coating, 80–119. Wiesbaden: Vieweg+Teubner, 2011. http://dx.doi.org/10.1007/978-3-8348-9896-8_4.

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Jiang, Tao, Xi-shan Li, Yong-bin Yang, Qian Li, and Jie Ge. "Separation of Roasted Coating and Core in Double-Layered Pellet Roasting for Pretreatment of Sulfur and Arsenic-Bearing Gold Concentrate." In Characterization of Minerals, Metals, and Materials 2015, 209–16. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119093404.ch26.

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Jiang, Tao, Xi-shan Li, Yong-bin Yang, Qian Li, and Jie Ge. "Separation of Roasted Coating and Core in Double-Layered Pellet Roasting for Pretreatment of Sulfur and Arsenic-Bearing Gold Concentrate." In Characterization of Minerals, Metals, and Materials 2015, 209–16. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-48191-3_26.

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Whiteman, C. David. "Precipitation." In Mountain Meteorology. Oxford University Press, 2000. http://dx.doi.org/10.1093/oso/9780195132717.003.0015.

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Precipitation is often the primary weather factor affecting outdoor activities. Precipitation that is of an unexpected type or intensity or that comes at an unexpected time or recurs more frequently than expected can disrupt both recreational and natural resource management plans. Heavy rain or snowfall can interfere with travel and threaten safety. Precipitation is water, whether in liquid or solid form, that falls from the atmosphere and reaches the ground. Table 8.1, adapted from Federal Meteorological Handbook No. 1 (National Weather Service, 1995), describes the different types of precipitation particles, collectively called hydrometeors. International guidelines for the reporting of precipitation do not include a category for sleet. Meteorologists in the United States use the term to describe tiny ice pellets that form when rain or partially melted snowflakes refreeze before reaching the ground. These particles bounce when they strike the ground and produce tapping sounds when they hit windows. Colloquial usage of the term, often used by the news media, coincides with British usage, which defines sleet as a mixture of rain and snow. Snow pellets, or graupel, are common in high mountain areas in summer. Graupel are low density particles (i.e., not solid ice) formed when a small ice particle (an ice crystal, snowflake, ice pellet, or small hailstone) falls through a cloud of supercooled (section 8.4) water droplets. The tiny droplets freeze as they impact the larger ice particle, building it into a rounded mass containing air inclusions (figure 8.1). This coating of granular ice particles is called rime, and the particle is said to be rimed. Graupel is usually produced in deep convective clouds that extend above the freezing level. Whereas graupel reaches the ground at high elevations, it usually melts to form rain before reaching the ground at lower elevations. As falling snow accumulates, a snowpack develops that can be described in terms of water content and density. The water content of snow is usually expressed as specific gravity, a number obtained in this application by dividing the water-depth equivalent of snow by the actual snow depth.
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"Precision Pelleted Seed." In Seed Inoculation, Coating and Precision Pelleting, 214–321. CRC Press, 2015. http://dx.doi.org/10.1201/b19298-11.

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"Precision Pelleted Seed." In Seed Inoculation, Coating and Precision Pelleting, 186–219. CRC Press, 2015. http://dx.doi.org/10.1201/b19298-6.

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"Process and Formulation Factors Affecting Drug Release from Pellets Coated with Ethylcellulose Pseudolatex Aquacoat®." In Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 223–56. CRC Press, 2008. http://dx.doi.org/10.3109/9780849387883-11.

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"Process and Formulation Factors Affecting Drug Release from Pellets Coated with the Ethylcellulose-Pseudolatex Aquacoat®." In Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 191–220. CRC Press, 2016. http://dx.doi.org/10.1201/9781315369938-15.

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"coating layer itself, an d at the interface between the coating and the substrate, causes instant fracturing and separation of coating material from the surface. In general, if a coating or contaminant is CHEMICALLY bonded to a surface, dry ice particle blasting will NOT effectively remove the coating. If the bond is PHYSICAL o r MECHANICAL in nature, such as a coating of rubber residue which is "anchored" into the porous surface of an aluminum casting, then there is a good chance that dr y ice blasting will work. Contaminants which are etched, or stained into the surfaces of metals, ceramics, plastics, or other materials typically cannot be removed with dry ice blasting. If the surface of the substrate is extremely porous or rough, providing strong mechanical "anchoring" for the contaminant or coating, dr y ice blasting may not be able to remove all of the coating, or the rate of removal may be too slow to allow dry ice blasting to be cost effective. The classic example of a contaminant that does NOT respond to dry ice blast-ing is RUST. Rust is both chemically and strongly mechanically bonded to steel substrate. Advanced stages of rust must be "chiseled" away with abrasive sand blasting. Only the thin film of powderized "flash" rust on a fresh steel surface can be effectively removed with dry ice blasting. 4.2.1.1. Inductio n (venturi) and direct acceleration blast systems - the effect of the typ e of system on available kinetic energy In a two-hose induction (venturi) carbon dioxide blastin g system, the medium particles are moved from the hopper to the "gun" chamber by suction, where they drop to a very low velocity before being induced into the outflow of the nozzle by a large flow volume of compressed air. Some more advanced two-hose systems employ a small positive pressure to the pellet delivery hose. In any type of two-hose system, since the blast medium particles have only a short distance in which to gain momentum and accelerate to the nozzle exit (usually only 200 to 300 mm), the final particle average velocity is limited to between 60 and 120 meters per second. So, in general, two-hose systems, although not so costly, are limited in their ability to deliver contaminant removal kinetic energy to the surface to be cleaned. When more blasting energy is required, these systems must be "boosted" a t the expense of much more air volume required, and higher blast pressure is re-quired as well, with much more nozzle back thrust, and very much more blast noise generated at the nozzle exit plane. The other type of solid carbon dioxide medium blasting system is like the "pressurized pot" abrasive blasting system common in the sand blasting and Plas-ti c Media Blasting industries. These systems use a single delivery hose from the hopper to the "nozzle" applicator in which both the medium particles and the compressed air travel. These systems are more complex and a little more costly than the inductive two-hose systems, but the advantages gained greatly outweigh the extra initial expense. In a single-hose solid carbon dioxide particle blasting system, sometimes referred to as a "direct acceleration " system, the medium is introduced from the hopper into a single, pre-pressurized blast hose through a sealed airlock feeder. The particles begin their acceleration and velocity increase." In Surface Contamination and Cleaning, 162–63. CRC Press, 2003. http://dx.doi.org/10.1201/9789047403289-25.

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Conference papers on the topic "Coating of pellets"

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Mozina, Miha, Miran Burmen, Dejan Tomazevic, Franjo Pernus, and Bostjan Likar. "Automatic visual inspection of pharmaceutical pellets in coating process." In 2009 IEEE International Conference on Industrial Technology. IEEE, 2009. http://dx.doi.org/10.1109/icit.2009.4939618.

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Bellisario, D., F. Quadrini, L. Santo, and G. M. Tedde. "Manufacturing of Antibacterial Additives by Nano-Coating Fragmentation." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6415.

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This study demonstrates the potential of a novel technique called nano-coating fragmentation to produce silver nanocomposites with antibacterial properties. This process starts from the production of an antibacterial additive without the separate production of silver nanoparticles. The additive was produced by depositing a silver nanofilm on polypropylene (PP) pellets by a physical vapor deposition sputtering process. Different set of sputtering parameters were used and different percentage of Ag were deposited on pellets. Afterwards, PP coated pellets were inserted in an injection molding machine to produce, in a single step, the nanocomposite by using shear forces. In facts, nanoparticles originate by the fragmentation of nano-coatings. The homogenously distributed silver particles were observed by microscope onto the nanocomposite surfaces. Thermal and mechanical properties of the nanocomposites were measured as well. The presence of dispersed nanofiller was confirmed by DSC analysis of the molded samples.
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Yebo Li, Jun Li, Zhe Liu, R. Roger Ruan, and Zhihuai Mao. "Vacuum Coating of Heat Sensitive Liquid Ingredient into Feed Pellets." In 2001 Sacramento, CA July 29-August 1,2001. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2001. http://dx.doi.org/10.13031/2013.7467.

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Burmen, Miran, Miha Mozina, Franjo Pernus, and Bostjan Likar. "Coating film thickness of pharmaceutical pellets measured by near infrared spectroscopy." In 2010 IEEE International Conference on Industrial Technology (ICIT 2010). IEEE, 2010. http://dx.doi.org/10.1109/icit.2010.5472679.

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Deng, Yangbin, Bowen Qiu, Yingwei Wu, Dalin Zhang, Wenxi Tian, Suizheng Qiu, and G. H. Su. "Simulation on Pellet-Cladding Mechanical Interaction (PCMI) of Accident Tolerant Fuel (ATF) With Coated Cladding." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66774.

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In this study, based on the code FROBA (Fuel ROd Behavior Analysis), a thermal-mechanical analysis code initially developed for traditional UO2-Zr fuel elements by our research group, a modified version named FROBA-ATF was developed to perform the fuel performance simulation of ATFs with different claddings, including Zr-4, SiC and Zr-4 coated with SiC. Compared with initial version, the cladding could be divided into arbitrary number control volumes with different materials in the new code, so it can be used to perform the calculation for multilayer coatings. In addition, a new non-rigid PCMI calculation model was established in the new code. Neither of the cladding and the pellet was regarded as the rigid body in this study, which means it can provide more accurate prediction compared with the rigid-fuel model in the initial code when Pellet-cladding Mechanical Interaction (PCMI) happened. The FROBA-ATF code was used to predict PCMI performance of two kind fuels with coated claddings, including the internal-surface coating and external-surface coating. The calculation result indicates that because the coating surface was close to the inner surface of the clad where also was the PCMI surface, the absolute value of the combine pressure of internal-surface coated cladding was substantial larger than that of the external-surface coated cladding, which might be harmful the coating behavior. However, the internal-surface coated mode can provide a protection for alloy due to the isolation from direct contact with fuel pellets, which can result in a much lower equivalent stress of zirconium body during the PCMI.
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H-E. Y. Ibrahim, Yousif, Katalin Kristó, Géza Regdon, and Tamás Sovány. "Development and optimization of the coating processes of lysozyme loaded pellets for oral delivery." In III. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2021. http://dx.doi.org/10.14232/syrptbrs.2021.op36.

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Zhang, Jinke, Yaochun Shen, and Yalin Zheng. "The Application of Full-Field Optical Coherence Tomography on Evaluating Film Coating of Pharmaceutical Pellets." In 2015 IEEE International Conference on Computer and Information Technology; Ubiquitous Computing and Communications; Dependable, Autonomic and Secure Computing; Pervasive Intelligence and Computing (CIT/IUCC/DASC/PICOM). IEEE, 2015. http://dx.doi.org/10.1109/cit/iucc/dasc/picom.2015.159.

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Oman, Nika, Miha Mozina, Dejan Tomazevic, Franjo Pernus, and Bostjan Likar. "A study of a visual inspection technique for in-process monitoring of coating of pharmaceutical pellets." In 2011 IEEE International Conference on Industrial Technology (ICIT 2011). IEEE, 2011. http://dx.doi.org/10.1109/icit.2011.5754380.

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Haaser, Miriam, Youness Karrout, Carine Velghe, Yvonne Cuppok, Keith Gordon, Michael Pepper, Jürgen Siepmann, Clare Strachan, Philip Taday, and Thomas Rades. "Evaluating critical film coating characteristics of sustained-release coated pellets with different size using terahertz pulsed imaging." In The 2nd Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI, 2012. http://dx.doi.org/10.3390/ecps2012-00808.

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Gregor-Svetec, Diana, and Tadeja Šumrada. "Packaging paper coated with PLA." In 10th International Symposium on Graphic Engineering and Design. University of Novi Sad, Faculty of technical sciences, Department of graphic engineering and design,, 2020. http://dx.doi.org/10.24867/grid-2020-p33.

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Nowadays, eco-design of products is becoming one of the most important directions at packaging development. Efficient use of materials, use of materials from renewable sources, design for recycling and reuse are especially important. In our research, we were interested in the development of sustainable, biodegradable protective paper packaging. In order to make packaging resistant against water, paper was coated with a biodegradable biopolymer, instead of using synthetic polymer. The base packaging paper was coated with a PLA solution, which was obtained by dissolving PLA pellets in dichloromethane. Two different concentrations were used. Technological and surface properties of coated paper were determined. The results of analyses have shown that sustainable packaging paper with good surface properties and barrier against water can be obtained by coating it with a PLA solution. Comparison with a commercial packaging paper has shown, that for PLA coated paper even higher water resistance was obtained.
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Reports on the topic "Coating of pellets"

1

Battaglia, Francine. Detailed Reaction Kinetics for CFD Modeling of Nuclear Fuel Pellet Coating for High Temperature Gas-Cooled Reactors. Office of Scientific and Technical Information (OSTI), November 2008. http://dx.doi.org/10.2172/942124.

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