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Journal articles on the topic 'Cocaïne – pharmacologie'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Richards, John R., Judd E. Hollander, Edward A. Ramoska та ін. "β-Blockers, Cocaine, and the Unopposed α-Stimulation Phenomenon". Journal of Cardiovascular Pharmacology and Therapeutics 22, № 3 (2016): 239–49. http://dx.doi.org/10.1177/1074248416681644.

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Cocaine abuse remains a significant worldwide health problem. Patients with cardiovascular toxicity from cocaine abuse frequently present to the emergency department for treatment. These patients may be tachycardic, hypertensive, agitated, and have chest pain. Several pharmacological options exist for treatment of cocaine-induced cardiovascular toxicity. For the past 3 decades, the phenomenon of unopposed α-stimulation after β-blocker use in cocaine-positive patients has been cited as an absolute contraindication, despite limited and inconsistent clinical evidence. In this review, the authors

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2

Benshoff, John J., and T. F. Riggar. "Cocaine: A Primer for Rehabilitation Counselors." Journal of Applied Rehabilitation Counseling 21, no. 3 (1990): 21–24. http://dx.doi.org/10.1891/0047-2220.21.3.21.

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Details of the pharmacology, and physical/psychological consequences of cocaine use are presented. The rehabilitation of cocaine addicts is examined through outpatient and inpatient therapy. Basic guidelines for rehabilitation counselors working with cocaine addicts are provided.

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3

Engel, John D. "Cocaine: A Historical and Modern Perspective." American Journal of Cosmetic Surgery 10, no. 2 (1993): 127–33. http://dx.doi.org/10.1177/074880689301000209.

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The history of cocaine is a long and storied one that dates back to ancient times. More recently, cocaine has gained notoriety for its use as an illicit drug on the streets. Surgeons involved in cosmetic and functional surgery of the nose commonly use cocaine in their practice and should be well versed in the pharmacologic and physiologic effects of the drug.

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4

Haasen, C., J. Reimer, and I. Schäfer. "Treatment of Cocaine Dependence: No Standard, but Promising Innovations." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70253-6.

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Treatment of cocaine dependence focuses on achieving abstinence and reducing problems associated to cocaine use. Despite extensive research and clinical experience, no “gold standard” has emerged from the different treatment options that have been researched. In general, research has shown that the evidence level for the efficacy of psychosocial interventions is higher than for pharmacologic interventions. With respect to psychosocial interventions, the evidence shows that all those interventions studied show efficacy to some extent, without greater differences in efficacy.With respect to the

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5

Carbone, Salvatore, Benjamin Van Tassell, Antonio Abbate, et al. "2438." Journal of Clinical and Translational Science 1, S1 (2017): 37–38. http://dx.doi.org/10.1017/cts.2017.138.

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OBJECTIVES/SPECIFIC AIMS: Cocaine use is a significant health problem in the United States and associated with increased risk of adverse cardiovascular outcomes. Our goal was to evaluate the effects of rapid cocaine infusions on cardiovascular hemodynamics among patients with cocaine abuse disorder. METHODS/STUDY POPULATION: Patients with a history of cocaine abuse but no overt cardiovascular disease received 4 consecutive intravenous infusions of cocaine (0, 10, 20, 40 mg) given in randomized, double-blinded order. The infusion procedure was repeated on 2 consecutive days (4 infusions each da

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6

Lacombe, Sylvia, Steven W. Stanislav, and Patricia A. Marken. "Pharmacologic Treatment of Cocaine Abuse." DICP 25, no. 7-8 (1991): 818–23. http://dx.doi.org/10.1177/106002809102500718.

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7

Gawin, Frank, and Herbert Kleber. "Pharmacologic Treatments of Cocaine Abuse." Psychiatric Clinics of North America 9, no. 3 (1986): 573–83. http://dx.doi.org/10.1016/s0193-953x(18)30614-2.

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8

Lipton, Jack W., Kile P. Mangan, and Jean M. Silvestri. "Acute Cocaine Toxicity: Pharmacology and Clinical Presentations in Adult and Pediatric Populations." Journal of Pharmacy Practice 13, no. 2 (2000): 159–69. http://dx.doi.org/10.1177/089719000001300207.

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Cocaine remains the most prevalent drug responsible for emergency department (ED) visits. A majority of acute cocaine toxicity cases involve young, habitual, adult cocaine users and often present with a range of cardiac, neurologic, gastrointestinal (GI) or renal symptoms. In addition, atypical populations (neonates, infants, toddlers, young children and adolescents) are presenting in EDs with varying symptoms that are unknowingly associated with cocaine exposure. Unfortunately, juvenile presentations are generally anecdotal in nature, and while enlightening, are difficult to quantify epidemio

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9

Richards, John R., Valeria F. Farias, and Chris S. Clingan. "Association of Leukocytosis with Amphetamine and Cocaine Use." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/207651.

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Objective. Determining the etiology of unexplained leukocytosis in asymptomatic patients may incur unnecessary testing, cost, and prolonged emergency department stay. The objective was to delineate if use of amphetamines and/or cocaine is a factor.Methods. For two years we reviewed all psychiatric patients presenting for medical clearance with exclusions for infection, epilepsy, trauma, or other nonpsychiatric medical conditions.Results. With a total of 1,206 patients, 877 (72.7%) amphetamines/cocaine-negative drug screen controls had mean WBC8.4±2.6×103/µL. The 240 (19.9%) amphetamines-positi

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10

Smith, M., D. Garner, and J. Niemann. "Pharmacologic interventions in acute cocaine toxicity." Annals of Emergency Medicine 18, no. 4 (1989): 446. http://dx.doi.org/10.1016/s0196-0644(89)80663-8.

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11

Santos, Glenn-Milo, Janet Ikeda, Phillip Coffin, et al. "Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial." PLOS ONE 16, no. 7 (2021): e0254724. http://dx.doi.org/10.1371/journal.pone.0254724.

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Objective To determine if men who have sex with men (MSM) with cocaine use disorder (CUD) and actively-using cocaine could be enrolled and retained in a pharmacologic intervention trial of lorcaserin—a novel 5-HT2cR agonist—and determine the degree to which participants would adhere to study procedures. Methods This was a phase II randomized, double-blind, placebo-controlled pilot study with 2:1 random parallel group assignment to daily extended-release oral lorcaserin 20 mg versus placebo (clinicaltrials.gov identifier-NCT03192995). Twenty-two of a planned 45 cisgender MSM with CUD were enrol

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12

Farrar, Henry C., and Gregory L. Kearns. "Cocaine: Clinical pharmacology and toxicology." Journal of Pediatrics 115, no. 5 (1989): 665–75. http://dx.doi.org/10.1016/s0022-3476(89)80640-7.

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13

Guha, Prasun, Maged M. Harraz, and Solomon H. Snyder. "Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade." Proceedings of the National Academy of Sciences 113, no. 5 (2016): 1417–22. http://dx.doi.org/10.1073/pnas.1524860113.

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Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the cytotoxic actions of cocaine reflect selective enhancement of autophagy, a process that physiologically degrades metabolites and cellular organelles, and that uncontrolled autophagy can also lead to cell death. In brain cultures, cocaine markedly increases levels of LC3-II and depletes p62, both actions characteristic of autophagy. By contrast, cocaine fails to stimu

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14

Bernards, Christopher M., Christian Kern, and Bruce F. Cullen. "Chronic Cocaine Administration Reversibly Increases Isoflurane Minimum Alveolar Concentration in Sheep." Anesthesiology 85, no. 1 (1996): 91–95. http://dx.doi.org/10.1097/00000542-199607000-00013.

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Background Significant numbers of patients are seen for surgery and anesthesia with a history of chronic cocaine use. However, little is known about how cocaine use influences anesthetic physiology and pharmacology. The purpose of this study was to investigate the effect of chronic cocaine exposure on the minimum alveolar concentration (MAC) of isoflurane in sheep. Methods Isoflurane MAC was determined at baseline in 12 sheep using a standard protocol. The animals were subsequently exposed to cocaine for 18 days. Cocaine exposure consisted of a continuous subcutaneous cocaine infusion at 0.2 m

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15

Kohnen-Johannsen, Kathrin, and Oliver Kayser. "Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production." Molecules 24, no. 4 (2019): 796. http://dx.doi.org/10.3390/molecules24040796.

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Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are characterized by their unique bicyclic tropane ring system, can be divided into three major groups: hyoscyamine and scopolamine, cocaine and calystegines. Although all TAs have the same basic structure, they differ immensely in their biological, chemical and pharmacological properties. Scopolamine, also known as hyoscine, has the largest legitimate market as a pharmacological agent due to its treatment of nausea, vomiti

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16

Kleber, Herbert D. "Pharmacologic Treatments for Heroin and Cocaine Dependence." American Journal on Addictions 12 (October 12, 2003): S5—S18. http://dx.doi.org/10.1111/j.1521-0391.2003.tb00552.x.

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17

Kleber, Herbert D. "Pharmacologic Treatments for Heroin and Cocaine Dependence." American Journal on Addictions 12, no. 2 (2003): S5—S18. http://dx.doi.org/10.1080/10550490390210083.

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18

Zeiter, John H., John G. McHenry, and Mark L. McDermott. "Unilateral pharmacologic mydriasis secondary to crack cocaine." American Journal of Emergency Medicine 8, no. 6 (1990): 568–69. http://dx.doi.org/10.1016/0735-6757(90)90181-x.

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19

Biebuyck, Julien F., Julia A. Fleming, Robert Byck, and Paul G. Barash. "Pharmacology and Therapeutic Applications of Cocaine." Anesthesiology 73, no. 3 (1990): 518–31. http://dx.doi.org/10.1097/00000542-199009000-00024.

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20

Benowitz, Neal L. "Clinical Pharmacology and Toxicology of Cocaine." Pharmacology & Toxicology 72, no. 1 (1993): 3–12. http://dx.doi.org/10.1111/j.1600-0773.1993.tb01331.x.

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21

Marwah, Joe. "Frontiers in cocaine research." Canadian Journal of Physiology and Pharmacology 67, no. 9 (1989): 1153. http://dx.doi.org/10.1139/y89-183.

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In Canada and the United States, cocaine abuse has become a serious drug problem. Cocaine elicits a multitude of behavioural, biochemical, and physiological effects, which depend on the dose, pattern, and route of administration. The recent upsurge in cocaine abuse and the attendant psychiatric problems, the adverse effects, and the lack of knowledge regarding the underlying mechanisms have provided an impetus for investigations on its mechanisms of action and for discovering newer treatment approaches. To date no specific mechanism of action can fully account for the psychotropic actions of c

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22

Carroll, Kathleen, Douglas Ziedonis, Stephanie O'Malley, Elinore McCance-Katz, Lynn Gordon, and Bruce Rounsaville. "Pharmacologic Interventions for Alcohol- and Cocaine-Abusing Individuals." American Journal on Addictions 2, no. 1 (2010): 77–79. http://dx.doi.org/10.1111/j.1521-0391.1993.tb00372.x.

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23

Jonas, Jeffrey M., and Mark S. Gold. "The Pharmacologic Treatment of Alcohol and Cocaine Abuse." Psychiatric Clinics of North America 15, no. 1 (1992): 179–90. http://dx.doi.org/10.1016/s0193-953x(18)30264-8.

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24

Zentner, Joseph L. "Cocaine: Pharmacology, Effects, and Treatment of Abuse." Journal of Psychoactive Drugs 17, no. 2 (1985): 135–37. http://dx.doi.org/10.1080/02791072.1985.10472334.

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25

Dackis, Charles A., and Charles P. O'Brien. "Neurobiology of Cocaine Dependence Limits Development of Pharmacologic Treatments." Psychiatric Annals 33, no. 9 (2003): 565–70. http://dx.doi.org/10.3928/0048-5713-20030901-07.

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26

Zhang, Sheng, Simon Zhornitsky, Thang M. Le, and Chiang-Shan R. Li. "Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence." International Journal of Neuropsychopharmacology 22, no. 12 (2019): 754–64. http://dx.doi.org/10.1093/ijnp/pyz044.

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Abstract Background Individuals with cocaine addiction are characterized by under-responsiveness to natural reinforcers. As part of the dopaminergic pathways, the hypothalamus supports motivated behaviors. Rodent studies suggested inter-related roles of the hypothalamus in regulating drug and food intake. However, few studies have investigated hypothalamic responses to drugs and food or related cues in humans. Methods We examined regional responses in 20 cocaine-dependent and 24 healthy control participants exposed to cocaine/food (cocaine dependent) and food (healthy control) vs neutral cues

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27

Lione, Armand. "Cocaine, marijuana, designer drugs: Chemistry, pharmacology and behavior." Reproductive Toxicology 5, no. 3 (1991): 273–74. http://dx.doi.org/10.1016/0890-6238(91)90086-u.

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28

Carrera, M. Rocı́o A., Michael M. Meijler, and Kim D. Janda. "Cocaine pharmacology and current pharmacotherapies for its abuse." Bioorganic & Medicinal Chemistry 12, no. 19 (2004): 5019–30. http://dx.doi.org/10.1016/j.bmc.2004.06.018.

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29

Martin, Miquel, Miriam Gutiérrez-Martos, Roberto Cabrera, et al. "Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice." Psychopharmacology 238, no. 7 (2021): 1923–36. http://dx.doi.org/10.1007/s00213-021-05820-z.

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ABSTRACT Rationale Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in different plants and vegetables like soybeans that share a common chemical structure. Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities. Objectives Based on these previous studies, we investigated the effects of three natural isoflavones, daidzin, daidzein, and genistein, on the modulation

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30

Smith, Pauline, Karim N’Diaye, Maeva Fortias, Luc Mallet, and Florence Vorspan. "I can’t get it off my mind: Attentional bias in former and current cocaine addiction." Journal of Psychopharmacology 34, no. 11 (2020): 1218–25. http://dx.doi.org/10.1177/0269881120944161.

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Background: Cocaine addiction is a global health issue with limited therapeutic options and a high relapse rate. Attentional bias towards substance-related cues may be an important factor for relapse. However, it has never been compared in former and current cocaine-dependent patients. Methods: Attentional bias towards cocaine-related words was assessed using an emotional Stroop task in cocaine-dependent patients ( N = 40), long-term abstinent former cocaine-dependent patients ( N = 24; mean abstinence: 2 years) and control subjects ( N = 28). Participants had to name the colour of cocaine-rel

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31

Mahoney, James J., Ari D. Kalechstein, Thomas F. Newton, and Richard De La Garza. "The limited impact that cocaine use patterns have on neurocognitive functioning in individuals with cocaine use disorder." Journal of Psychopharmacology 31, no. 8 (2017): 989–95. http://dx.doi.org/10.1177/0269881117715606.

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It is well-documented in the literature that cocaine use is associated with neurocognitive impairment. The manner in which patterns of cocaine use, such as years of use, recent use over the past month, and daily amount of cocaine use, moderate neurocognition has been studied in a relatively piecemeal manner. Hence, the purpose of the study was to evaluate whether cocaine use patterns modulate neurocognition in individuals with cocaine use disorder. Cocaine users who were cocaine-negative ( n=125) were divided into tertiles based on cocaine use patterns and the performances of the highest and l

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32

Larson, Tracey A., Casey E. O’Neill, Michaela P. Palumbo, and Ryan K. Bachtell. "Effects of adolescent caffeine consumption on cocaine self-administration and reinstatement of cocaine seeking." Journal of Psychopharmacology 33, no. 1 (2018): 132–44. http://dx.doi.org/10.1177/0269881118812098.

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Background: Caffeine consumption by children and adolescents has risen dramatically in recent years, yet the lasting effects of caffeine consumption during adolescence remain poorly understood. Aim: These experiments explore the effects of adolescent caffeine consumption on cocaine self-administration and seeking using a rodent model. Methods: Sprague-Dawley rats consumed caffeine for 28 days during the adolescent period. Following the caffeine consumption period, the caffeine solution was replaced with water for the remainder of the experiment. Age-matched control rats received water for the

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33

Lindemann, Anna. "Scientific Objectivity and Subjectivity in Eighteenth Century Pharmacology." Perspectives on Science 27, no. 6 (2019): 787–809. http://dx.doi.org/10.1162/posc_a_00325.

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This article examines an often neglected topic in the history of science, namely clinical observation, specifically the objectivity and knowledge production associated with therapeutic trials. It will describe an eighteenth and nineteenth century pharmacological concept of objectivity and exemplify that concept using late nineteenth century European cocaine research. As conceived within clinical drug research, this concept of objectivity does not correspond with those described by Daston and Galison in their seminal book Objectivity (2007). I will explore the implications of this “new” concept

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34

Jaffe, Jerome H., Nicola G. Cascella, Karen M. Kumor, and Michael A. Sherer. "Cocaine-induced cocaine craving." Psychopharmacology 97, no. 1 (1989): 59–64. http://dx.doi.org/10.1007/bf00443414.

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35

Okada, Tsuyoshi, Katsutoshi Shioda, Akiko Makiguchi, and Shiro Suda. "Risperidone and 5-HT2A Receptor Antagonists Attenuate and Reverse Cocaine-Induced Hyperthermia in Rats." International Journal of Neuropsychopharmacology 23, no. 12 (2020): 811–20. http://dx.doi.org/10.1093/ijnp/pyaa065.

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Abstract Background Cocaine (benzoylmethylecgonine) is one of the most widely used illegal psychostimulant drugs worldwide, and mortality from acute intoxication is increasing. Suppressing hyperthermia is effective in reducing cocaine-related mortality, but a definitive therapy has not yet been found. In this study, we assessed the ability of risperidone to attenuate acute cocaine-induced hyperthermia and delineated the mechanism of its action. Methods Rats were injected i.p. with saline, risperidone, ketanserin, ritanserin, haloperidol, or SCH 23 390 before and after injection of cocaine (30

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36

Pizzoglio, Véronique, Anne-Marie Patat, and Alexandra Boucher. "Cocaïne basée et chlorhydrate de cocaïne : pharmaco-toxicologie comparée." Therapies 73, no. 6 (2018): 588. http://dx.doi.org/10.1016/j.therap.2018.09.045.

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37

Vaughan, D. Ann. "Frontiers in Pharmacologic Treatment of Alcohol, Cocaine, and Nicotine Dependence." Psychiatric Annals 20, no. 12 (1990): 695–710. http://dx.doi.org/10.3928/0048-5713-19901201-05.

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38

You, In-Jee, Sa-Ik Hong, Shi-Xun Ma, et al. "Transient receptor potential vanilloid 1 mediates cocaine reinstatement via the D1 dopamine receptor in the nucleus accumbens." Journal of Psychopharmacology 33, no. 12 (2019): 1491–500. http://dx.doi.org/10.1177/0269881119864943.

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Purpose: The transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that mediates synaptic modification in the nucleus accumbens (NAc). However, no study has yet examined the mechanism of TRPV1 in the NAc on cocaine reinstatement. We investigated the mechanism of TRPV1 in NAc on cocaine reinstatement using the conditioned place preference (CPP) test in mice. Methods: We examined the effect of capsazepine (5 mg/kg, a TRPV1 antagonist, administered intraperitoneally (i.p.)), capsaicin (0.3 mg/kg, a TRPV1 agonist, administered i.p.), and genetic deletion of TRPV1 on the

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39

Watson, William A. "Longitudinal Assessment of Cocaine Toxicity in Emergency Department Patients." Journal of Pharmacy Practice 6, no. 2 (1993): 74–82. http://dx.doi.org/10.1177/089719009300600206.

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Longitudinal data are necessary to identify changes in drug abuse and resultant toxicity. The development of COC-LOG, a longitudinal database used to assess cocaine-associated emergency department patient visits at Truman Medical Center, the University of Missouri-Kansas City, is described. COC-LOG currently contains 1,054 patient visits. The data demonstrate that cocaine toxicity has remained relatively constant in our emergency department (ED) over the last 4 years. The majority of cocaine use is through smoking crack, and major differences in toxicity are not seen between this route and IV

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40

Dolan, Sean B., Ritu A. Shetty, Michael J. Forster, and Michael B. Gatch. "Impure but not inactive: Behavioral pharmacology of dibenzylpiperazine, a common by-product of benzylpiperazine synthesis." Journal of Psychopharmacology 32, no. 7 (2018): 802–10. http://dx.doi.org/10.1177/0269881118780613.

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Background: Substituted piperazines comprise a substantial proportion of the novel psychoactive substance market. Among the most widely abused piperazine compounds are meta-chlorophenylpiperazine (mCPP), tri-fluoromethylphenylpiperazine (TFMPP), and, especially, benzylpiperazine (BZP), which are commonly incorporated, either alone or in combination, in illicit “party pills” or “ecstasy” formulations. Illicit synthesis of BZP often results in production of an impure by-product dibenzylpiperazine (DBZP), which frequently appears alongside BZP in these formulations; however, despite its ubiquity,

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Le Foll, B., J. C. Schwartz, and P. Sokoloff. "Dopamine D3 receptor agents as potential new medications for drug addiction." European Psychiatry 15, no. 2 (2000): 140–46. http://dx.doi.org/10.1016/s0924-9338(00)00219-4.

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SummaryAll drugs abused by humans increase dopamine in the shell of nucleus accumbens, which implicate the neurons of this structure in their hedonic and reinforcing properties. Among the various dopamine receptor subtypes, the D1 (D1R) and D3 (D3R) receptors co-localise in accumbal shell neurons. Synergistic D1R/D3R interactions at this level were found on gene expression and during induction and expression of behavioral sensitisation to levodopa in rats bearing unilateral lesions of dopamine neurons. Behavioral sensitisation to abused drugs is a component of their long-term effects. Convergi

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Ciccarone, Daniel. "Stimulant Abuse: Pharmacology, Cocaine, Methamphetamine, Treatment, Attempts at Pharmacotherapy." Primary Care: Clinics in Office Practice 38, no. 1 (2011): 41–58. http://dx.doi.org/10.1016/j.pop.2010.11.004.

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43

Calpe-López, Claudia, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares, Jose Miñarro, and Maria A. Aguilar. "Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice." Journal of Psychopharmacology 35, no. 7 (2021): 864–74. http://dx.doi.org/10.1177/0269881120965952.

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Background: Cocaine dependence is an important problem without any effective pharmacological treatment. Some preclinical studies have suggested that cannabidiol (CBD), a component of the Cannabis sativa plant, could be useful for the treatment of cocaine use disorders. Aims: This work aims to evaluate the ability of CBD to reduce priming- and stress-induced reinstatement of the conditioned place preference (CPP) induced by cocaine. Methods: Young adult CD-1 male mice were allocated to 10 groups ( n = 12/group), conditioned with cocaine (10 mg/kg) and exposed to extinction of CPP (two sessions

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Barbosa Méndez, Susana, and Alberto Salazar-Juárez. "Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal." Journal of Psychopharmacology 33, no. 5 (2019): 589–605. http://dx.doi.org/10.1177/0269881119840521.

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Background: Anxiety and depression, key symptoms of the cocaine withdrawal syndrome in human addicts, are considered the main factors that precipitate relapse in chronic cocaine addiction. Preclinical studies have found that rodents exposed to different withdrawal periods show an increase in anxiety and depressive-like behavior. Mirtazapine – a tetracyclic medication – is used primarily to treat depression and, sometimes, anxiety. It has also successfully improved withdrawal symptoms in drug-dependent patients. Aim: This study sought to determine whether chronic dosing of mirtazapine during co

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45

Zhornitsky, Simon, Isha Dhingra, Thang M. Le, Wuyi Wang, Chiang-shan R. Li, and Sheng Zhang. "Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task." International Journal of Neuropsychopharmacology 24, no. 8 (2021): 634–44. http://dx.doi.org/10.1093/ijnp/pyab016.

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Abstract Background Cocaine addiction is associated with altered sensitivity to natural reinforcers and intense drug craving. However, previous findings on reward-related responses were mixed, and few studies have examined whether reward responses relate to tonic cocaine craving. Methods We combined functional magnetic resonance imaging and a monetary incentive delay task to investigate these issues. Imaging data were processed with published routines, and the results were evaluated with a corrected threshold. We compared reward responses of 50 cocaine-dependent individuals (CDs) and 45 health

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46

Koren, Gideon, Karen Graham, Annette Feigenbaum, and Tom Einarson. "Evaluation and Counseling of Teratogenic Risk: The Motherisk Approach." Journal of Pharmacy Practice 6, no. 5 (1993): 245–51. http://dx.doi.org/10.1177/089719009300600509.

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The authors present a new approach for evaluation and counseling of teralogenic risk. The Motherisk program in Toronto presently deals with 60 inquiries per day from the public and health professionals. Most calls are answered through the telephone, and 16–20 women per week are scheduled for our clinic following exposure to known or suspected teratogens, to new drugs with sparse information, to chronic drug therapy, or drugs of abuse. Also seen in clinic are women who want to be counseled or whose physicians want them to meet us due to high levels of anxiety. Since its inception in 1985 the Pr

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Connelly, Krista L., and Ellen M. Unterwald. "Regulation of CRF mRNA in the Rat Extended Amygdala Following Chronic Cocaine: Sex Differences and Effect of Delta Opioid Receptor Agonism." International Journal of Neuropsychopharmacology 23, no. 2 (2019): 117–24. http://dx.doi.org/10.1093/ijnp/pyz067.

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Abstract Background Cocaine withdrawal activates stress systems. Females are more vulnerable to relapse to cocaine use and more sensitive to withdrawal-induced negative affect. Delta opioid receptors modulate anxiety-like behavior during cocaine withdrawal in rats. This study measured the time course of gene regulation of one of the main stress peptides, corticotropin-releasing factor (CRF), and its type 1 receptor in male and female rats as well as the ability of the delta opioid receptor agonist SNC80 to normalize cocaine withdrawal-induced changes in CRF mRNA. Methods Rats were injected wit

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Wang, Ju-Feng, Xinhua Yan, Jiangyong Min, Matthew F. Sullivan, Thomas G. Hampton, and James P. Morgan. "Cocaine downregulates cardiac SERCA2a and depresses myocardial function in the murine model." Canadian Journal of Physiology and Pharmacology 80, no. 10 (2002): 1015–21. http://dx.doi.org/10.1139/y02-128.

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Cocaine has been shown to depress myocardial function, which may be linked to abnormal Ca2+ handling by the sarcoplasmic reticulum (SR). To examine whether cocaine affects Ca2+-handling proteins and myocardial performance, we injected BALB/c mice with cocaine daily (30 mg/kg, i.p.) for 14 d. Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) levels, phospholamban (PLB) protein levels, and hemodynamic parameters were measured. After cocaine exposure, myocardial function was significantly decreased both in vivo and in vitro. Also, SERCA2a protein levels were significantly decreased in all cocaine-trea

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Lile, Joshua A., William W. Stoops, Paul EA Glaser, Lon R. Hays, and Craig R. Rush. "Discriminative stimulus, subject-rated and cardiovascular effects of cocaine alone and in combination with aripiprazole in humans." Journal of Psychopharmacology 25, no. 11 (2010): 1469–79. http://dx.doi.org/10.1177/0269881110385597.

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Aripiprazole is a dopamine D2 receptor partial agonist undergoing evaluation as a pharmacotherapy for stimulant-use disorders. Acutely administered aripiprazole attenuates the discriminative stimulus and other behavioral effects of d-amphetamine in humans; however, whether aripiprazole attenuates the effects of more commonly abused stimulants is unknown. The aim of this experiment was to assess the discriminative stimulus, subject-rated and cardiovascular effects of oral cocaine alone and following acute administration of aripiprazole in humans. Eight cocaine-dependent subjects learned to disc

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Kohut, Stephen J., Peter A. Fivel, Bruce E. Blough, Richard B. Rothman, and Nancy K. Mello. "Effects of methcathinone and 3-Cl-methcathinone (PAL-434) in cocaine discrimination or self-administration in rhesus monkeys." International Journal of Neuropsychopharmacology 16, no. 9 (2013): 1985–98. http://dx.doi.org/10.1017/s146114571300059x.

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Abstract Monoamine releasers with varying selectivity for dopamine (DA)/norepinephrine and serotonin (5-HT) release are potential treatment medications for cocaine abuse. Although DA-selective monoamine releasers effectively reduce cocaine abuse, their clinical usefulness is limited by abuse liability. It is hypothesized that increasing 5-HT neurotransmission may reduce the abuse-related effects of DA releasers, but the optimal DA:5-HT release ratio remains to be determined. This study in rhesus monkeys compared the effects of two compounds with differing potency for 5-HT release. Methcathinon

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