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Relevant bibliographies by topics / Cochleate Nanocochleates

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Journal articles

Academic literature on the topic 'Cochleate Nanocochleates'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Cochleate Nanocochleates"

1

Harwalkar Mallappa S, Salunkhe Kishor S, Chintamani Ravindra B, and Raosaheb Sopanrao S. "Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2884–94. http://dx.doi.org/10.26452/ijrps.v11i3.2369.

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The nanocochleates are mainly prepared from the liposomes of active pharmaceutical ingredients (APIs) with the help of inactive ingredients like phosphatidylserine (PS) and calcium. The PS shows a considerable binding affinity towards calcium mainly due to the calcium’s tendency to lose part of its hydration shell and to displace water upon complexation. Due to neutralization of the electrostatic charge, calcium causes aggregation & fusion of liposomes composed PS with each other. It has been reported that ca++ has an affinity to form a more tightly packed & highly ordered and less hyd

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2

Samruddhi, More* Prajakta Kangutkar Shital Kamble Dr. D. R. Jadage. "Nanocochleates As a Novel Lipid-Based Nano Carrier for Enhanced Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1535–44. https://doi.org/10.5281/zenodo.15380480.

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As a type of lipid-based nanocarrier, nanocochleates have demonstrated great promise in improving drug delivery. They are made up of lipid bilayers that are rolled up into a cochleate structure, which provides a unique platform for encapsulating drugs. It has been demonstrated that nanocochleates improve drug stability, target specific tissues or cells, and provide controlled release of drugs. Because of their lipid-based composition, which makes them biocompatible and biodegradable, the use of nanocochleates for drug delivery has several benefits, such as increased efficacy, decreased side ef

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3

Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the

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GR1, Godge. "An Overview of Nanocochleates for Improving Oral Absorption Using a Phospolipid-Based Drug Delivery System." Bioequivalence & Bioavailability International Journal 8, no. 2 (2024): 1–11. http://dx.doi.org/10.23880/beba-16000236.

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A novel approach to oral and systemic drug delivery is nanaocochleate. It is a brand-new lipid-based system that offers a distinct technological platform appropriate for the systemic and oral delivery of numerous compounds with significant biologically therapeutic properties, such as medications, genes, and vaccine antigens. The technology of nanocochleate formulation is especially useful for hydrophobic macromolecules and small molecules with low oral bioavailability, as well as those that are negatively or positively charged. Research on the proof-of-principle of cochleate-mediated oral deli

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5

Vajir, Shaikh* Dipak Bade Anuradha Salunkhe Pravin Patil Omkar Bhagat Ajinkya Nalawade Shivanjali Shelake. "An Overview of Nanocochleates for Improving Oral Absorption of Antifungal Drugs Using a Phospolipid-Based Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2387–98. https://doi.org/10.5281/zenodo.15421913.

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Nanaocochleate is a unique method of systemic and oral medication delivery. It is a novel lipid-based system that provides a unique technical platform suitable for the oral and systemic delivery of several substances with important medically therapeutic qualities, including genes, vaccine antigens, and pharmaceuticals. Hydrophobic macromolecules, tiny compounds with low oral bioavailability, and negatively or positively charged molecules are particularly well-suited for the technique of nanocochleate formulation. Clinically relevant, well-established medications that are now only provided by i

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6

Kesharwani, Anubhav* Pandey Prince Ram Vishal. "Nanocochleates: A Novel Platform in Delivery Therapeutic Cargo." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3350–57. https://doi.org/10.5281/zenodo.15471652.

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This review article explores the exciting potential of nanocochleates as a novel drug delivery platform. Lipid-based drug delivery (LDDs) systems attract increasing interest in the pharmaceutical industry due to their advantages in solubility and bioavailability of poorly water-soluble drugs. Nanocochleates are the lipid based multi-layered spiral structure that resemble a small shell-like structure which is achieved through the interaction of negatively charged lipid and positively charged calcium ions which causes lipid bilayer to roll into cochlear-like structure. Due to these structures na

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7

Sharma, Rahul, Ashwini Deshpande, and Abhishek Kanugo. "Formulation Optimization and Evaluation of Nanocochleate Gel of Famciclovir for the Treatment of Herpes Zoster." Recent Patents on Nanotechnology 16 (June 22, 2022). http://dx.doi.org/10.2174/1872210516666220622115553.

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Background: Herpes zoster is a viral infection triggered due to the reactivation of the varicella-zoster virus in the posterior dorsal root ganglion. Herpes zoster infections occur mostly in the facial, cervical and thoracic region of the body beginning with pain and resulted in the vesicular eruption. Recently, this infection is observed during the Covid-19 pandemic and also after the induction of mRNA-based vaccine for coronavirus at an extended level. Nanocochleates are cylindrical (cigar-shape) microstructure lipid-based versatile carriers for the drug delivery systems. Famciclovir is an a

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8

Dr., Meghana R. Babar Naveena. V. Vengala Juhi Singh. "SERRATIOPEPTIDASE LOADED NANOCOCHLEATE: NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYATEM." September 28, 2020. https://doi.org/10.5281/zenodo.4056525.

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<em>Objective: Nanoochleates are tubular or cockle shaped structures derived from liposomes. Although investigated for several applications to be administered by oral and parenteral route, the potential of cochleates in topical drug delivery remains unexplored. The present study is a comprehensive report aimed at ascertaining the role of cochleates in topical delivery of drugs.Methods involved development and evaluation of lipoid S 75 based nanocochleate formulation of serratiopeptidase. A 2<sup>3</sup> factorial design was utilized to optimize nanocochleate formulation and to study effect of

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9

Somnath, Gore Aarti, Gondkar Tejas Sandip, and Manjusha P. Mhaske. "Nanocochleate A Novel Drug Delivery System." Research Journal of Pharmaceutical Dosage Forms and Technology, March 10, 2025, 63–68. https://doi.org/10.52711/0975-4377.2025.00009.

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The current situation offers a variety of lipid-based nanocarrier technologies. Multi-layered cochleates stand out among these lipid-based nanocarriers as an innovative nanocarrier system for hydrophilic and hydrophobic medicines with enhanced drug permeability, stability, and dose reduction. Additionally, it aids in site-specific medication delivery with fewer side effects and increases the oral bioavailability of hydrophilic and hydrophobic medicines. There are numerous ways to create nanocochleates, and they can be utilized to deliver a wide range of active compounds for a wide range of app

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10

Rub, Rukhsana, Neha Munot, and Akshay Wadate. "Improved Efficacy and Stability of Silymarin Loaded Nanocochleates Over Liposomes for the Treatment of Skin Diseases." Journal of Pharmaceutical Research International, August 21, 2021, 163–76. http://dx.doi.org/10.9734/jpri/2021/v33i41b32355.

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Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, and membrane-stabilizing property is being investigated in several dermatological conditions. Present research aims to evaluate potential of silymarin loaded nanocochleates and liposomal topical application for treating chronic skin diseases. Study Design: Silymarin loaded liposomes and nanocochleates were formulated and optimized using Design Expert software. Different invitro and exvivo tests were performed to compare their performance. Place and Duration of Study: The study was conduct

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