Log in

Relevant bibliographies by topics / Cocrystallization studies / Journal articles

To see the other types of publications on this topic, follow the link: Cocrystallization studies.

Journal articles on the topic 'Cocrystallization studies'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Cocrystallization studies.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Ren, Zhongqi, Xinjian Chen, Guojia Yu, Yinglei Wang, Bin Chen, and Zhiyong Zhou. "Molecular simulation studies on the design of energetic ammonium dinitramide co-crystals for tuning hygroscopicity." CrystEngComm 22, no. 31 (2020): 5237–44. http://dx.doi.org/10.1039/d0ce00602e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Timofeeva, Tatiana, Sofia Antal, Sergiu Draguta, Karla Ordonez, Raul Castaneda, and Evgeniya Leonova. "Cocrystallization of acetaminophen and glutaric acid with different coformers." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1028. http://dx.doi.org/10.1107/s2053273314089712.

Full text

Abstract:

Recently cocrystallization became a popular tool for crystal engineering that allows, for instance, improving properties of pharmaceutical materials, creating new materials for nonlinear optical applications and solar cell technologies. To attract students to crystallographic studies we carried out project that included crystal growth of two series of cocrystals with acetaminophen and with dicarbonic glutaric acid. We attempted cocrystallization of acetaminophen with more than ten different coformers which gave no cocrystals or salts. However, as a result of cocrystallization we obtained new p

APA, Harvard, Vancouver, ISO, and other styles

3

Manoj, K., Rui Tamura, Hiroki Takahashi, and Hirohito Tsue. "Crystal engineering of homochiral molecular organization of naproxen in cocrystals and their thermal phase transformation studies." CrystEngComm 16, no. 26 (2014): 5811–19. http://dx.doi.org/10.1039/c3ce42415d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Duan, Binghui, Yuanjie Shu, Ning Liu, et al. "Comparative studies on structure, sensitivity and mechanical properties of CL-20/DNDAP cocrystal and composite by molecular dynamics simulation." RSC Advances 8, no. 60 (2018): 34690–98. http://dx.doi.org/10.1039/c8ra07387b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

SOLOMON, CRISTINA. "PREFORMULATION STUDIES OF TABLETS CONTAINING RIVAROXABAN – NIACINAMIDE COCRYSTALLIZATION COMPOUNDS." FARMACIA 73, no. 3 (2025): 706–12. https://doi.org/10.31925/farmacia.2025.3.17.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Xu, Jia, Qin Shi, Yanan Wang, et al. "Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals." Molecules 28, no. 2 (2023): 613. http://dx.doi.org/10.3390/molecules28020613.

Full text

Abstract:

Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including anticancer, anti-inflammatory, antiviral and antioxidant properties, which makes them extensively studied. In order to improve the properties of flavonoids, such as solubility and bioavailability, the formation of cocrystals may be a feasible strategy. This review discusses in detail the possible hydrogen bond sites in the structure of APIs and the h

APA, Harvard, Vancouver, ISO, and other styles

7

Asojo, Oluwatoyin Ajibola, Oluyomi Adebola Asojo, Michelle N. Ngamelue, Kohei Homma, and Oksana Lockridge. "Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine." Acta Crystallographica Section F Structural Biology and Crystallization Communications 67, no. 4 (2011): 434–37. http://dx.doi.org/10.1107/s1744309111004805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Hiendrawan, Stevanus, Bambang Veriansyah, and Raymond R. Tjandrawinata. "SOLID-STATE PROPERTIES AND SOLUBILITY STUDIES OF NOVEL PHARMACEUTICAL COCRYSTAL OF ITRACONAZOLE." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 97. http://dx.doi.org/10.22159/ijap.2018v10i5.26663.

Full text

Abstract:

Objective: Pharmaceutical cocrystal is a promising method to improve the solubility of active pharmaceutical ingredients (APIs). Itraconazole (ITZ) is a BCS class II antifungal drug with poor aqueous solubility, therefore an attempt was made to improve the solubility of ITZ using cocrystallization technique. In this work, six novel pharmaceutical cocrystals of ITZ with various coformers, including 4-hydroxybenzoic acid (4HBA), trans-cinnamic acid (TCA), suberic acid (SUB), sebacic acid (SBC), 1-hydroxy-2-naphthoic acid (1H2N), and benzamide (BZD) were prepared.Methods: ITZ cocrystals was prepa

APA, Harvard, Vancouver, ISO, and other styles

9

Shahbaz, Muhammad, Umair Ahmed Khan, M. Iqbal Chaudhary, and Sammer Yousuf. "A new bioactive cocrystal of coumarin-3-carboxylic acid and thiourea: detailed structural features and biological activity studies." Acta Crystallographica Section C Structural Chemistry 78, no. 3 (2022): 192–200. http://dx.doi.org/10.1107/s205322962200081x.

Full text

Abstract:

Cocrystallization is a phenomenon widely used to enhance the biological and physicochemical properties of active pharmaceutical ingredients (APIs). The present study deals with the synthesis of a cocrystal of coumarin-3-carboxylic acid (2-oxochromene-3-carboxylic acid, C10H6O4), a synthetic analogue of the naturally occurring antioxidant coumarin, with thiourea (CH4N2S) using the neat grinding method. The purity and homogeneity of the coumarin-3-carboxylic acid–thiourea (1/1) cocrystal was confirmed by single-crystal X-ray diffraction, FT–IR analysis and thermal stability studies based on diff

APA, Harvard, Vancouver, ISO, and other styles

10

Mikheev, N. B., I. V. Melikhov, and S. A. Kulyukhin. "Cocrystallization processes in physicochemical studies of radioactive elements in various media." Radiochemistry 49, no. 6 (2007): 549–60. http://dx.doi.org/10.1134/s106636220706001x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Carlucci, Lucia, and Angelo Gavezzotti. "A quantitative measure of halogen bond activation in cocrystallization." Physical Chemistry Chemical Physics 19, no. 28 (2017): 18383–88. http://dx.doi.org/10.1039/c7cp03322b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Salgado-Moran, Guillermo, Rodrigo Ramirez-Tagle, Daniel Glossman-Mitnik, et al. "Docking Studies of Binding of Ethambutol to the C-Terminal Domain of the Arabinosyltransferase fromMycobacterium tuberculosis." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/601270.

Full text

Abstract:

The binding of ethambutol to the C-terminal domain of the arabinosyltransferase fromMycobacterium tuberculosiswas studied. The analysis was performed using anin silicoapproach in order to find out, by docking calculations and energy descriptors, the conformer of Ethambutol that forms the most stable complex with the C-terminal domain of arabinosyltransferase. The complex shows that location of the Ethambutol coincides with the cocrystallization ligand position and that amino acid residues ASH1051, ASN740, ASP1052, and ARG1055 should be critical in the binding of Ethambutol to C-terminal domain

APA, Harvard, Vancouver, ISO, and other styles

13

CHAMPAGNE, Claude P., Yves RAYMOND, Francine MONDOU, and Jean-Paul JULIEN. "Studies on the Encapsulation of Bifidobacterium longum Cultures by Spray-Coating or Cocrystallization." Bifidobacteria and Microflora 14, no. 1 (1995): 7–14. http://dx.doi.org/10.12938/bifidus1982.14.1_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Mashhadi, Syed Muddassir Ali, Andrei S. Batsanov, Syed Arslan Sajjad, Yasir Nazir, Moazzam Hussain Bhatti, and Uzma Yunus. "Isoniazid-Gentisic acid cocrystallization: Solubility, Stability, Dissolution rate, Antioxidant and Flowability Properties Studies." Journal of Molecular Structure 1226 (February 2021): 129388. http://dx.doi.org/10.1016/j.molstruc.2020.129388.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Pindelska, Edyta, Anita Sarna, Maciej Duszczyk, Anna Zep, and Izabela D. Madura. "Enhancing Febuxostat Solubility Through Cocrystal Formation: Role of Substrate Selection and Amide Coformers." International Journal of Molecular Sciences 26, no. 7 (2025): 3004. https://doi.org/10.3390/ijms26073004.

Full text

Abstract:

Solubility plays a crucial role in drug bioavailability and therapeutic efficacy. Febuxostat (FEB), a BCS Class II drug used to treat hyperuricemia and gout, has low solubility, limiting its effectiveness. Cocrystallization offers a strategy to enhance solubility without modifying the drug’s chemical structure. While FEB exhibits multiple polymorphic forms, no prior studies have explored cocrystal formation from its commercially available hemihydrate. This study examines whether FEB’s initial form—hemihydrate or anhydrous—affects cocrystal formation. We investigated cocrystals with aromatic am

APA, Harvard, Vancouver, ISO, and other styles

16

Gołdyn, Mateusz, Anna Komasa, Mateusz Pawlaczyk, Aneta Lewandowska, and Elżbieta Bartoszak-Adamska. "Salts of purine alkaloids caffeine and theobromine with 2,6-dihydroxybenzoic acid as coformer: structural, theoretical, thermal and spectroscopic studies." Acta Crystallographica Section C Structural Chemistry 77, no. 11 (2021): 713–24. http://dx.doi.org/10.1107/s2053229621010883.

Full text

Abstract:

The study of various forms of pharmaceutical substances with specific physicochemical properties suitable for putting them on the market is one of the elements of research in the pharmaceutical industry. A large proportion of active pharmaceutical ingredients (APIs) occur in the salt form. The use of an acidic coformer with a given structure and a suitable pK a value towards purine alkaloids containing a basic imidazole N atom can lead to salt formation. In this work, 2,6-dihydroxybenzoic acid (26DHBA) was used for cocrystallization of theobromine (TBR) and caffeine (CAF). Two novel salts, nam

APA, Harvard, Vancouver, ISO, and other styles

17

Kyu, Thein, and Parimal Vadhar. "Cocrystallization and miscibility studies of blends of ultrahigh molecular weight polyethylene with conventional polyethylenes." Journal of Applied Polymer Science 32, no. 6 (1986): 5575–84. http://dx.doi.org/10.1002/app.1986.070320625.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gao, Lei, and Xianrui Zhang. "Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis." Journal of Chemistry 2021 (December 16, 2021): 1–8. http://dx.doi.org/10.1155/2021/3834368.

Full text

Abstract:

Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4′-bipyridine (BIP), 3-aminopyridine (3AP) and 4-hydroxypyridine (4HP), were designed to improve the solubility of FEB. The single-crystal structures were elucidated, and their physical and chemical properties were investigated by IR, PXRD, and DSC. In addition, drug-related properties, including the solubility and powder dissolution rate were assessed. T

APA, Harvard, Vancouver, ISO, and other styles

19

Brandt, Ali K., Derek J. Boyle, Jacob P. Butler, et al. "Molecular Recognition and Shape Studies of 3- and 4-Substituted Diarylamide Quasiracemates." Crystals 11, no. 12 (2021): 1596. http://dx.doi.org/10.3390/cryst11121596.

Full text

Abstract:

Families of quasiracemic materials constructed from 3- and 4-substituted chiral diarylamide molecular frameworks were prepared, where the imposed functional group differences systematically varied from H to CF3–9 unique components for each isomeric framework. Cocrystallization from the melt via hot stage thermomicroscopy using all possible racemic and quasiracemic combinations probed the structural boundaries of quasiracemate formation. The crystal structures and lattice energies (differential scanning calorimetry and lattice energy calculations) for many of these systems showed that quasienan

APA, Harvard, Vancouver, ISO, and other styles

20

Dalgarno, Scott J., Daniel B. Bassil, Sheryl A. Tucker, and Jerry L. Atwood. "Cocrystallization and Encapsulation of a Fluorophore with Hexameric Pyrogallol[4]arene Nanocapsules: Structural and Fluorescence Studies." Angewandte Chemie 118, no. 42 (2006): 7177–80. http://dx.doi.org/10.1002/ange.200601961.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Dalgarno, Scott J., Daniel B. Bassil, Sheryl A. Tucker, and Jerry L. Atwood. "Cocrystallization and Encapsulation of a Fluorophore with Hexameric Pyrogallol[4]arene Nanocapsules: Structural and Fluorescence Studies." Angewandte Chemie International Edition 45, no. 42 (2006): 7019–22. http://dx.doi.org/10.1002/anie.200601961.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Emami, Shahram, Mohammadreza Siahi-Shadbad, Khosro Adibkia, and Mohammad Barzegar-Jalali. "Recent advances in improving oral drug bioavailability by cocrystals." BioImpacts 8, no. 4 (2018): 305–20. http://dx.doi.org/10.15171/bi.2018.33.

Full text

Abstract:

Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy. Improving oral absorption of drugs with low water solubility and/or low intestinal membrane permeability is an active field of research. Cocrystallization of drugs with appropriate coformers is a promising approach for enhancing oral bioavailability. Methods: In the present review, we have focused on recent advances that have been made in improving oral absorption through cocrystallization. The covered areas incl

APA, Harvard, Vancouver, ISO, and other styles

23

Hoffmann, Sven, Bert Vanhaecht, Jan Devroede, Wim Bras, Cor E. Koning, and Sanjay Rastogi. "Cocrystallization in Piperazine-Based Polyamide Copolymers: Small- and Wide-Angle X-ray Diffraction Studies at 30 °C." Macromolecules 38, no. 5 (2005): 1797–803. http://dx.doi.org/10.1021/ma048456e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Faizan, Mohd, Vítor Hugo Nunes Rodrigues, and Shabbir Ahmad. "Cocrystallization of 2,3-dimethylquinoxaline with 3,5-dinitrobenzoic acid: Crystal structure, Hirshfeld surface, spectroscopic features and DFT studies." Journal of Molecular Structure 1198 (December 2019): 126894. http://dx.doi.org/10.1016/j.molstruc.2019.126894.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Wróblewska, Aneta, Justyna Śniechowska, Sławomir Kaźmierski, et al. "Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals." Pharmaceutics 12, no. 4 (2020): 359. http://dx.doi.org/10.3390/pharmaceutics12040359.

Full text

Abstract:

Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methanol) or mechanochemically by grinding. The progress of cocrystal formation in a ball mill was monitored by means of high-resolution, solid state NMR spectroscopy. The 13C CP/MAS, 15N CP/MAS and 1H Very Fast (VF) MAS NMR procedures were employed to inspect the tautomeric forms of the APIs, structure elucidation of the coformer and the obtained cocryst

APA, Harvard, Vancouver, ISO, and other styles

26

Aditya Gaurav, Aditya Gaurav, Dr Upendra Kumar Sharma Dr. Upendra Kumar Sharma, and Dr Bhawna Sharma Dr. Bhawna Sharma. "Co-Crystallization: A technique to develop a better pharmaceutical formulatio." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 753–61. https://doi.org/10.35629/4494-1003753761.

Full text

Abstract:

There are many potential drug molecules which cannot be used in formulation because of poor solubility, instability, poor bioavailability etc. To resolve these problems certain techniques such as salt formation, hydrates and Co-crystallization are used. Also, this technique is used to create multidrug co-crystals and in formulation of sustained release drug. Cocrystallization is very beneficial technique in order to gain patient of co-crystal of API molecule because of the novelty of the drug. This review article is about Co-crystallization; its method of preparation like Grinding method, Solv

APA, Harvard, Vancouver, ISO, and other styles

27

Saikia, Prakash J., Narendra N. Dass, and Shashi D. Baruah. "Cocrystallization behavior of poly(n-docosyl acrylate) withn-docosanoic acid by X-ray and differential scanning calorimetry studies." Journal of Applied Polymer Science 97, no. 5 (2005): 2140–46. http://dx.doi.org/10.1002/app.21951.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Chavan, Dhanashri D., Vandana M. Thorat, Amol S. Shete, and Rohit R. Bhosale. "SOLVENT ASSISTED COCRYSTALLIZATION OF ITRACONAZOLE: SOLID-STATE PROPERTIES, DISSOLUTION, STABILITY, ANTIFUNGAL POTENTIAL, AND SOLUTION-MEDIATED PHASE TRANSFORMATION STUDIES." RASAYAN Journal of Chemistry 18, no. 02 (2025): 1011–21. https://doi.org/10.31788/rjc.2025.1829256.

Full text

Abstract:

The physical form of drugs significantly influences their effectiveness, particularly for BCS Class II compounds. The interplay between crystal structure and formulation is critical in determining bioavailability. Crystal engineering has emerged as an efficient tool to increase the solid-state characteristics of APIs while preserving their intrinsic structures. This study focused on itraconazole (ITZ), a poorly water-soluble drug, developing pharmaceutical cocrystals via the solvent drop grinding technique using various coformers to enhance solubility, dissolution rate, and bioavailability. Th

APA, Harvard, Vancouver, ISO, and other styles

29

Tilborg, Anaelle, Andrea Carletta, and Johan Wouters. "Structural and energy insights on solid-state complexes with trimethoprim: a combined theoretical and experimental investigation." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 71, no. 4 (2015): 406–15. http://dx.doi.org/10.1107/s2052520615008422.

Full text

Abstract:

We present here a new structure of a 1:1 salt of trimethoprim with hemifumarate, highlighted by single-crystal X-ray diffraction and computational conformational studies. This salt was formed during cocrystallization assays conducted to combine trimethoprim and other APIs whose combination exhibits interesting properties. Theoreticalin vacuoinvestigations have been performed on the organic salt through a DFT two-dimensional conformational scan of torsion angles between the two aromatic moieties of trimethoprim. The evaluation of relative energies for hydrogen-bond interactions in the structure

APA, Harvard, Vancouver, ISO, and other styles

30

Mohana, Marimuthu, Packianathan Thomas Muthiah, and Colin D. McMillen. "Supramolecular architectures in two 1:1 cocrystals of 5-fluorouracil with 5-bromothiophene-2-carboxylic acid and thiophene-2-carboxylic acid." Acta Crystallographica Section C Structural Chemistry 73, no. 6 (2017): 481–85. http://dx.doi.org/10.1107/s2053229617007550.

Full text

Abstract:

In solid-state engineering, cocrystallization is a strategy actively pursued for pharmaceuticals. Two 1:1 cocrystals of 5-fluorouracil (5FU; systematic name: 5-fluoro-1,3-dihydropyrimidine-2,4-dione), namely 5-fluorouracil–5-bromothiophene-2-carboxylic acid (1/1), C5H3BrO2S·C4H3FN2O2, (I), and 5-fluorouracil–thiophene-2-carboxylic acid (1/1), C4H3FN2O2·C5H4O2S, (II), have been synthesized and characterized by single-crystal X-ray diffraction studies. In both cocrystals, carboxylic acid molecules are linked through an acid–acid R 2 2(8) homosynthon (O—H...O) to form a carboxylic acid dimer and

APA, Harvard, Vancouver, ISO, and other styles

31

P. Ahirrao, Sapana, Mayur P. Sonawane, Deepak S. Bhambere, et al. "Cocrystal Formulation: A Novel Approach to Enhance Solubility and Dissolution of Etodolac." Biosciences Biotechnology Research Asia 19, no. 1 (2022): 111–19. http://dx.doi.org/10.13005/bbra/2971.

Full text

Abstract:

Etodolac (ETD) is a non-steroidal anti-inflammatory drug (NSAID) given in rheumatoid arthritis treatment. As it comes under BCS class II drug hence it exhibits low water solubility. Also, its dissolution rate-limited oral absorption results in delayed onset of action. The Novel approach in the solubility enhancement field; crystal engineering was preferred to prepare pharmaceutical cocrystals of etodolac with GRAS (generally recognized as safe) molecules. Pharmaceutical cocrystals of etodolac were prepared with p-hydroxybenzoic acid and glutaric acid with the drug: coformer ratio 1:1 and 1:2.

APA, Harvard, Vancouver, ISO, and other styles

32

Kaplan, Nachum, Monique Albert, Donald Awrey, et al. "Mode of Action,In VitroActivity, andIn VivoEfficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5865–74. http://dx.doi.org/10.1128/aac.01411-12.

Full text

Abstract:

ABSTRACTThe mechanism of action of AFN-1252, a selective inhibitor ofStaphylococcus aureusenoyl-acyl carrier protein reductase (FabI), which is involved in fatty acid biosynthesis, was confirmed by using biochemistry, macromolecular synthesis, genetics, and cocrystallization of an AFN-1252–FabI complex. AFN-1252 demonstrated a low propensity for spontaneous resistance development and a time-dependent reduction of the viability of both methicillin-susceptible and methicillin-resistantS. aureus, achieving a ≥2-log10reduction inS. aureuscounts over 24 h, and was extremely potent against clinical

APA, Harvard, Vancouver, ISO, and other styles

33

Abdullah, Abulkhair, Muhammad Subhan A. Sibadu, and Mutmainnah Mutmainnah. "Aktivitas Antibakteri Kokristal Sefiksim-Nikotinamida Menggunakan Agar Diffusion dan Broth Dilution Test." Jurnal Sains dan Kesehatan 5, no. 6 (2023): 886–92. http://dx.doi.org/10.25026/jsk.v5i6.2069.

Full text

Abstract:

Cefixime has been formulated in cocrystal form with nicotinamide (coformer). SEF-NIK cocrystals were prepared at a mole ratio of 1:1 using a liquid-assisted grinding method. The cocrystals were characterized using DSC, FTIR, SEM, and PXRD. The characterization results showed that cocrystals were formed between cefixime and nicotinamide. The results of the solubility test, dissolution rate and permeability of the SEF-NIK cocrystal showed a significant increase compared to pure cefixime. Based on these results, the SEF-NIK cocrystal was continued for pharmacodynamic studies with in vitro antibac

APA, Harvard, Vancouver, ISO, and other styles

34

Rodríguez-Ruiz, Christian, Pedro Montes-Tolentino, Jorge Guillermo Domínguez-Chávez, Hugo Morales-Rojas, Herbert Höpfl, and Dea Herrera-Ruiz. "Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal." Pharmaceutics 14, no. 2 (2022): 334. http://dx.doi.org/10.3390/pharmaceutics14020334.

Full text

Abstract:

A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF showed a supramolecular organization in which CAF molecules are embedded in channels of a 3D network of CTD molecules. The advantage of the cocrystal in comparison to CTD is reflected in a threefold solubility increase and in the dose/solubility ratios, which diminished from near-unit values for D0D to 0.29 for D0CC. Furthermore, dissolution experim

APA, Harvard, Vancouver, ISO, and other styles

35

Temel, Ersin, Can Alaşalvar, Hande Eserci, and Erbil Ağar. "Experimental (X-ray, IR and UV–vis.) and DFT studies on cocrystallization of two tautomers of a novel Schiff base compound." Journal of Molecular Structure 1128 (January 2017): 5–12. http://dx.doi.org/10.1016/j.molstruc.2016.08.038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Guan, Danyingzi, Bianfei Xuan, Chengguang Wang, et al. "Improving the Physicochemical and Biopharmaceutical Properties of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicine through Cocrystal Engineering." Pharmaceutics 13, no. 12 (2021): 2160. http://dx.doi.org/10.3390/pharmaceutics13122160.

Full text

Abstract:

Active pharmaceutical ingredients (APIs) extracted and isolated from traditional Chinese medicines (TCMs) are of interest for drug development due to their wide range of biological activities. However, the overwhelming majority of APIs in TCMs (T-APIs), including flavonoids, terpenoids, alkaloids and phenolic acids, are limited by their poor physicochemical and biopharmaceutical properties, such as solubility, dissolution performance, stability and tabletability for drug development. Cocrystallization of these T-APIs with coformers offers unique advantages to modulate physicochemical propertie

APA, Harvard, Vancouver, ISO, and other styles

37

Speetzen, Erin D., Chideraa I. Nwachukwu, Nathan P. Bowling та Eric Bosch. "Complementary, Cooperative Ditopic Halogen Bonding and Electron Donor-Acceptor π-π Complexation in the Formation of Cocrystals". Molecules 27, № 5 (2022): 1527. http://dx.doi.org/10.3390/molecules27051527.

Full text

Abstract:

This study expands and combines concepts from two of our earlier studies. One study reported the complementary halogen bonding and π-π charge transfer complexation observed between isomeric electron rich 4-N,N-dimethylaminophenylethynylpyridines and the electron poor halogen bond donor, 1-(3,5-dinitrophenylethynyl)-2,3,5,6-tetrafluoro-4-iodobenzene while the second study elaborated the ditopic halogen bonding of activated pyrimidines. Leveraging our understanding on the combination of these non-covalent interactions, we describe cocrystallization featuring ditopic halogen bonding and π-stackin

APA, Harvard, Vancouver, ISO, and other styles

38

Asha, R. Nandini, V. Vel Murugan, P. Pon Matheswari, S. Kumaresan, N. Bhuvanesh та B. Ravindran Durai Nayagam. "Cocrystallization of 2,4-Diamino-6-phenyl-1,3,5-triazine with β-(phenylthio)propionic acid: Crystal structure, Hirshfeld surface, DFT studies and molecular docking". Chemical Data Collections 29 (жовтень 2020): 100520. http://dx.doi.org/10.1016/j.cdc.2020.100520.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Ravaud, Stephanie, Patrice Gouet, Richard Haser, and Nushin Aghajari. "Probing the Role of Divalent Metal Ions in a Bacterial Psychrophilic Metalloprotease: Binding Studies of an Enzyme in the Crystalline State by X-Ray Crystallography." Journal of Bacteriology 185, no. 14 (2003): 4195–203. http://dx.doi.org/10.1128/jb.185.14.4195-4203.2003.

Full text

Abstract:

ABSTRACT The psychrophilic alkaline metalloprotease (PAP) produced by a Pseudomonas bacterium isolated in Antarctica belongs to the clan of metzincins, for which a zinc ion is essential for catalytic activity. Binding studies in the crystalline state have been performed by X-ray crystallography in order to improve the understanding of the role of the zinc and calcium ions bound to this protease. Cocrystallization and soaking experiments with EDTA in a concentration range from 1 to 85 mM have resulted in five three-dimensional structures with a distinct number of metal ions occupying the ion-bi

APA, Harvard, Vancouver, ISO, and other styles

40

Inam, Muhammad, Yi Yang, Jialin Hu, et al. "Cocrystallization of Gefitinib Potentiate Single-Dose Oral Administration for Lung Tumor Eradication via Unbalancing the DNA Damage/Repair." Pharmaceutics 15, no. 12 (2023): 2713. http://dx.doi.org/10.3390/pharmaceutics15122713.

Full text

Abstract:

Gefitinib (GEF) is a clinical medication for the treatment of lung cancer targeting the epidermal growth factor receptor (EGFR). However, its efficacy is remarkably limited by low solubility and dissolution rates. In this study, two cocrystals of GEF with co-formers were successfully synthesized using the recrystallization method characterized via Powder X-ray Diffraction, Fourier Transform Infrared Spectroscopy, and 2D Nuclear Overhauser Effect Spectroscopy. The solubility and dissolution rates of cocrystals were found to be two times higher than those of free GEF. In vitro cytotoxicity studi

APA, Harvard, Vancouver, ISO, and other styles

41

Wasim, Muhammad, Abdul Mannan, Muhammad Hassham Hassan Bin Asad, Muhammad Imran Amirzada, Muhammad Shafique, and Izhar Hussain. "Fabrication of Carbamazepine Cocrystals: Characterization, In Vitro and Comparative In Vivo Evaluation." BioMed Research International 2021 (March 15, 2021): 1–9. http://dx.doi.org/10.1155/2021/6685806.

Full text

Abstract:

Carbamazepine (CBZ) is an antiepileptic drug having low bioavailability due to its hydrophobic nature. In the current study, efforts are made to investigate the effect of dicarboxylic acid coformer spacer groups (aliphatic chain length) on physicochemical properties, relative humidity (RH) stability, and oral bioavailability of CBZ cocrystals. Slurry crystallization technique was employed for the preparation of CBZ cocrystals with the following coformers: adipic (AA), glutaric (GA), succinic (SA), and malonic acid (MA). Powder X-ray diffractometry and Fourier-transform infrared spectroscopy co

APA, Harvard, Vancouver, ISO, and other styles

42

Reddy, B. K. Kishore, Sudhir Landge, Sudha Ravishankar, et al. "Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors." Antimicrobial Agents and Chemotherapy 58, no. 6 (2014): 3312–26. http://dx.doi.org/10.1128/aac.00140-14.

Full text

Abstract:

ABSTRACTPantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by thecoaAgene is an essential pantothenate kinase inMycobacterium tuberculosis, and this vital information was then exploited to screen large libraries for identification of mechanistically different classes of PanK inhibitors. The present report summarizes the synthesis and expansion efforts to understand the structure-activity relationships leading to the o

APA, Harvard, Vancouver, ISO, and other styles

43

Lee, Hyo Jae, and Jae Woong Jung. "Thiourea-Induced Cocrystallization of Mixed-Halide Perovskite Thin Films for High-Performance Pure Blue Perovskite Light Emitting Diodes." ECS Meeting Abstracts MA2024-01, no. 22 (2024): 1344. http://dx.doi.org/10.1149/ma2024-01221344mtgabs.

Full text

Abstract:

Metal halide perovskite light-emitting diodes (PeLEDs) are gaining significant attention towards next-generation display materials owing to their advantageous properties, including color tunability, exceptionally narrow bandwidth, and high luminescence. Recent studies have successfully achieved over 20% external quantum efficiencies (EQE) in green and red PeLEDs. However, the blue PeLEDs lag far behind those of green or red PeLEDs because unstable phase stability in mixed halide perovskite thin films under high turn-on voltage (Von). In specific, the blue emission usually possesses halide ions

APA, Harvard, Vancouver, ISO, and other styles

44

Buysschaert, Geraldine, Kenneth Verstraete, Savvas N. Savvides, and Bjorn Vergauwen. "Crystallization of an atypical short-chain dehydrogenase fromVibrio vulnificuslacking the conserved catalytic tetrad." Acta Crystallographica Section F Structural Biology and Crystallization Communications 68, no. 7 (2012): 771–74. http://dx.doi.org/10.1107/s1744309112018672.

Full text

Abstract:

Short-chain dehydrogenases/reductases (SDRs) are a rapidly expanding superfamily of enzymes that are found in all kingdoms of life. Hallmarked by a highly conserved Asn-Ser-Tyr-Lys catalytic tetrad, SDRs have a broad substrate spectrum and play diverse roles in key metabolic processes. Locus tag VVA1599 inVibrio vulnificusencodes a short-chain dehydrogenase (hereafter referred to as SDRvv) which lacks the signature catalytic tetrad of SDR members. Structure-based protein sequence alignments have suggested that SDRvv may harbour a unique binding site for its nicotinamide cofactor. To date, stru

APA, Harvard, Vancouver, ISO, and other styles

45

Vallejo-Schmidt, Tamara, Cheyenne Palm, Trinity Obiorah, et al. "Characterization of the Structural Requirements for the NADase Activity of Bacterial Toll/IL-1R domains in a Course-based Undergraduate Research Experience." ImmunoHorizons 8, no. 8 (2024): 563–76. http://dx.doi.org/10.4049/immunohorizons.2300062.

Full text

Abstract:

Abstract TLRs initiate innate immune signaling pathways via Toll/IL-1R (TIR) domains on their cytoplasmic tails. Various bacterial species also express TIR domain-containing proteins that contribute to bacterial evasion of the innate immune system. Bacterial TIR domains, along with the mammalian sterile α and TIR motif-containing protein 1 and TIRs from plants, also have been found to exhibit NADase activity. Initial X-ray crystallographic studies of the bacterial TIR from Acinetobacter baumannii provided insight into bacterial TIR structure but were unsuccessful in cocrystallization with the

APA, Harvard, Vancouver, ISO, and other styles

46

Bala, Madhu, Manoj Kumar Gautam, and Renu Chadha. "What if Cocrystallization Fails for Neutral Molecules? Screening Offered Eutectics as Alternate Pharmaceutical Materials: Leflunomide-a Case Study." Pharmaceutical Sciences 25, no. 3 (2019): 235–43. http://dx.doi.org/10.15171/ps.2019.46.

Full text

Abstract:

Background: The manuscript is aimed to optimize the biopharmaceutical parameters of a poorly soluble, neutral anti-rheumatic drug ‘leflunomide’ by preparing its non-covalent derivatives (NCDs). For this various monocarboxylic acids- (adipic acid, picolinic acid) and dicarboxylic acids (maleic acid, malonic acid, sorbic acid), as well as pyridine carboxamide derivatives (nicotinamide, isonicotinamide), are used as coformers. Methods: The novel solid forms were rationally prepared and systematically characterized. Further, these solid forms were subjected to equilibrium solubility and intrinsic

APA, Harvard, Vancouver, ISO, and other styles

47

Srivastava, Dipti, Zeeshan Fatima, Chanchal D. Kaur, Sachin L. Tulsankar, Sanap S. Nashik, and Dilshad A. Rizvi. "Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug." Recent Patents on Drug Delivery & Formulation 13, no. 1 (2019): 62–69. http://dx.doi.org/10.2174/1872211313666190306160116.

Full text

Abstract:

Background: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben, its characterization and determination of its bioavailability. Candesartan is a poorly water-soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), and Valsartan (CN102702118B) for enhancement of solubility, helped in selection of the drug for this work. Methods: Candesartan cocrystal was prepared by solution crystallization method. The formation of a ne

APA, Harvard, Vancouver, ISO, and other styles

48

Pramanik, Titas, Mysore S. Pavan, and Tayur N. Guru Row. "Do halogen bonds dictate the packing preferences in solid solutions?" Faraday Discussions 203 (2017): 201–12. http://dx.doi.org/10.1039/c7fd00084g.

Full text

Abstract:

The isomeric compounds, 4-bromo-2-chloro benzoic acid (4Br) and 2-bromo-4-chlorobenzoic acid (2Br), crystallize in entirely different space groups, P2<sub>1</sub>/n and P1̄ respectively. Both structures are stabilized by a strong O–H⋯O hydrogen bonds generating a carboxylic acid dimer along with an unusual triangular halogen bonded motif in the former and a well-defined halogen bond in the latter. Charge density analysis establishes the nature of halogen bonds by bringing out significant changes in the packing features of the two structures as well as the quantification of the interaction ener

APA, Harvard, Vancouver, ISO, and other styles

49

Li, Congwei, Pengfei Du, Meilin Zhou та ін. "Spectroscopic Methodology and Molecular Docking Studies on Changes in Binding Interaction of Felodipine with Bovine Serum Albumin Induced by Cocrystallization with β-Resorcylic Acid". Chemical and Pharmaceutical Bulletin 68, № 10 (2020): 946–53. http://dx.doi.org/10.1248/cpb.c20-00212.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

González-González, Juan Saulo, Raquel Jiménez-López, David Ortegón-Reyna, Gabino Gonzalez-Carrillo, and Francisco Javier Martínez-Martínez. "Mechanochemical Synthesis of the Catechol-Theophylline Cocrystal: Spectroscopic Characterization and Molecular Structure." Applied Sciences 11, no. 9 (2021): 3810. http://dx.doi.org/10.3390/app11093810.

Full text

Abstract:

Pharmaceutical cocrystallization offers the possibility to modify the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients. The mechanochemical synthesis and spectroscopic characterization of the catechol-theophylline (CAT-TEO) cocrystal is reported. The cocrystal was prepared by the solvent-assisted grinding method. The ATR-IR spectroscopy study allowed to determine the formation of the cocrystal because the O-H and C=O stretching bands in the CAT-TEO cocrystal were shifted with respect to the starting materials, suggesting the formation of the C=O···H-O hydro

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!