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Journal articles on the topic 'Codependency – Treatment'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Adhikari, Suresh, Sagun Paudel, Sagun Ballav Pant, and Vidya Dev Sharma. "The prevalence of anxiety, depression and co-dependence among spouses of male patients with alcohol dependence syndrome at a tertiary care hospital in Nepal: A cross-sectional study." Journal of Psychiatrists' Association of Nepal 14, no. 1 (2025): 20–26. https://doi.org/10.3126/jpan.v14i1.80919.

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Introduction: Excessive use of alcohol is a major public health concern worldwide. Alcohol dependence is a constant source of stress for the families of alcohol users with dependence and makes them more vulnerable to psychological problems such as depression, anxiety and co-dependence. This study explores the prevalence of anxiety, depression and co-dependence among spouses of male patients with alcohol dependence syndrome. Methodology: A cross-sectional study was conducted among 93 spouses of male patients with alcohol dependence syndrome seeking treatment at the Department of Psychiatry, Tri

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Bortolon, Cassandra Borges, Luciana Signor, Taís de Campos Moreira, et al. "Family functioning and health issues associated with codependency in families of drug users." Ciência & Saúde Coletiva 21, no. 1 (2016): 101–7. http://dx.doi.org/10.1590/1413-81232015211.20662014.

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Abstract Substance abuse affects both the user and the family system as a whole, yet substance abuse treatment is centered on the user, leaving the family in the background. Objective: To identify the symptoms of codependency and health issues in the codependent family members of drug users who called a toll-free telephone counseling service. In total, 505 family members participated in this cross-sectional study. Drug users’ mothers and wives who had less than 8 years of education and those who were unemployed had a greater chance of high codependency. It was also determined that a high level

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3

Brent, John S. "An Outline for an Existential Approach to the Treatment of Codependency." Journal of Pastoral Care 47, no. 2 (1993): 157–66. http://dx.doi.org/10.1177/002234099304700208.

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Summarizes many of the themes in recent attempts to identify the nature of codependency and indicates how such themes tend to be addressed by existential theology and psychology. Outlines an applied process of existential counseling in the treatment of the codependent client and illustrates with a case example.

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Korostiy, V., H. Kozhyna, M. Markova, and V. Yaruj. "Clinical implications of codependency as a model of health disorders associated with stress, in wives of men with alcohol dependence." European Psychiatry 33, S1 (2016): S303. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1035.

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IntroductionThe potential adverse consequences, personal distress, shame and guilt presented by patients who suffer from codependency require a more in-depth understanding of the phenomenology of this disorder.ObjectiveTo determine targets of psychotherapy work with the codependency wives of men with alcohol dependence (AD).AimTo determine the features of clinical manifestations of codependency as a model of health disorders associated with stress.MethodsIntegrated clinical-psychopathological and psychodiagnostic research, using anxiety and depression scales M. Hamilton, scale of psychosocial

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Бельняк, Дмитрий. "Christian Understanding of Codependency as Depriving Oneself of Freedom." Вопросы богословия, no. 1(7) (July 15, 2022): 25–36. http://dx.doi.org/10.31802/pwg.2022.7.1.002.

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В данной статье автор рассматривает феномен созависимости с точки зрения православной аскетики. Феномен созависимости сравнивается с патристическими понятиями страсти и прелести. Рассматривается роль религии в лечении созависимости. Приведены примеры из жизни православных святых, в которых подвижники, выражаясь языком психологии, предотвратили развитие этого психологического расстройства. В результате автор приходит к выводу о необходимости тесного сотрудничества между психологической наукой и богословием, поскольку таким образом может быть достигнут целостный подход к лечению феномена созавис

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6

Walfish, Steven, and Anton M. Krone. "MMPI Profiles of Women in Codependency Treatment." Journal of Personality Assessment 58, no. 1 (1992): 211–14. http://dx.doi.org/10.1207/s15327752jpa5801_18.

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7

Chang, Shih-Hua. "A cultural perspective on codependency and its treatment." Asia Pacific Journal of Counselling and Psychotherapy 3, no. 1 (2012): 50–60. http://dx.doi.org/10.1080/21507686.2011.620973.

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8

Beheshti, Ronak, Peyman Hassani-Abharian, Leila Ganji, Salma Afzali Yazdi, Fatima Sheikh Ansari, and Samad Shabani Fard. "An Examination of the Effectiveness of Motivational Interviewing on State and Trait Anxiety and Depression Symptoms in Codependent Women with an Addicted Spouse." Journal of Psychological Dynamics in Mood Disorders 4, no. 1 (2025): 103–19. https://doi.org/10.61838/kman.pdmd.4.1.7.

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Objective: The aim of the present study was to examine the effectiveness of motivational interviewing on state and trait anxiety and depression symptoms in codependent women who have an addicted spouse. Methodology: This applied study employed a semi-experimental design with a pretest-posttest and a control group. The statistical population consisted of codependent women with an addicted spouse in the city of Tehran who, in the first quarter of 2024, visited self-help group centers and were selected based on an initial interview to determine eligibility for inclusion in the sample. The researc

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9

O'Gorman, Patricia. "Codependency explored: A social movement in search of definition and treatment." Psychiatric Quarterly 64, no. 2 (1993): 199–212. http://dx.doi.org/10.1007/bf01065870.

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10

Teichman, Meir, and Uri Basha. "Codependency and Family Cohesion and Adaptability: Changes during Treatment in a Therapeutic Community." Substance Use & Misuse 31, no. 5 (1996): 599–615. http://dx.doi.org/10.3109/10826089609045829.

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11

Akay, Osman, Esra Albal, Gülten Güleşen, and Gökhan Umut. "The Relationship between Addiction Severity and Co-Addiction Level in Individuals with Substance Use Disorder." Bağımlılık Dergisi 26, no. 2 (2024): 162–75. https://doi.org/10.51982/bagimli.1491201.

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Objective: This study aimed to examine the relationship between the addiction severity of individuals diagnosed with substance use disorder and the spouse addiction levels of family members. Method: Data were collected from 146 individuals and 146 family members who received addiction treatment at the adult detoxification center of a mental health hospital in Istanbul. Data were collected using sociodemographic information forms, the Addiction Profile Index (API), and the Codependency in Addiction Assessment Form (CAAF). Results: Of the 146 study participants, 128 (87.7%) were male; 84 of them

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Calderwood, Kimberly A., and Anne Rajesparam. "Applying the codependency concept to concerned significant others of problem gamblers: Words of caution." Journal of Gambling Issues, no. 29 (October 1, 2014): 1. http://dx.doi.org/10.4309/jgi.2014.29.11.

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Two competing models of understanding concerned significant others (CSOs) of people with addictions have emerged: codependency (CD) and stress-coping. In the context of CSOs of problem gamblers, some research has begun to examine the effectiveness of the stress-coping model, but no research to date has examined the utility of incorporating the CD concept into treatment planning. The purpose of this paper is to: critique the CD concept while highlighting possible differences between problem gambling and substance abuse (i.e., financial issues, the ability to hide the problem, cognitive distorti

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Elliott, Irmina A., Amanda M. Dann, Shili Xu, et al. "Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion." Proceedings of the National Academy of Sciences 116, no. 14 (2019): 6842–47. http://dx.doi.org/10.1073/pnas.1812410116.

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Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by lysosomal inhibition in PDAC have not been systematically explored. We performed a comprehensive pharmacological inhibition screen of the protein kinome and found that replication stress response (RSR) inhibitors were synthetically lethal with chloroquine (CQ) in PDAC cells. CQ treatment reduced de

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Liu, Yuxuan, Patrizia Mondello, Tatiana Erazo, et al. "NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death." Proceedings of the National Academy of Sciences 115, no. 47 (2018): 12034–39. http://dx.doi.org/10.1073/pnas.1806928115.

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Although diffuse large B cell lymphoma (DLBCL) cells widely express the BCL2 protein, they rarely respond to treatment with BCL2-selective inhibitors. Here we show that DLBCL cells harboring PMAIP1/NOXA gene amplification were highly sensitive to BCL2 small-molecule inhibitors. In these cells, BCL2 inhibition induced cell death by activating caspase 9, which was further amplified by caspase-dependent cleavage and depletion of MCL1. In DLBCL cells lacking NOXA amplification, BCL2 inhibition was associated with an increase in MCL1 protein abundance in a BIM-dependent manner, causing a decreased

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Lobanov, Serhii, Hanna Voshkolup, Mykhailo Zhylin, Olena Medvedieva, and Dmytro Usyk. "The Effect of Emotional Regulation for the Successful Treatment of Emotional Dependence in Young People." International Journal of Statistics in Medical Research 14 (March 25, 2025): 126–35. https://doi.org/10.6000/1929-6029.2025.14.13.

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Regulation of one’s own emotional state is of great importance for a person’s mental health. The issue under research is related to determining emotional regulation approaches for the success of the treatment of emotional dependence in young people. Methods. It was possible to achieve the set goal based on the use of methods of analysis, observation, the Spann-Fischer Codependency Scale, and the Student’s coefficient. The emotional regulation approaches developed by the authors included social recovery, analysis of someone else’s problem and behaviour, problem solving, and art therapy. Results

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Alvarado, Karen, Ilusca Janeiro, Sebastian Florez та ін. "Dissolution of the Primary γ′ Precipitates and Grain Growth during Solution Treatment of Three Nickel Base Superalloys". Metals 11, № 12 (2021): 1921. http://dx.doi.org/10.3390/met11121921.

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Second phase particles (SPP) play an essential role in controlling grain size and properties of polycrystalline nickel base superalloys. The understanding of the behavior of these precipitates is of prime importance in predicting microstructure evolutions. The dissolution kinetics of the primary γ′ precipitates during subsolvus solution treatments were investigated for three nickel base superalloys (René 65, AD730 and N19). A temperature-time codependency equation was established to describe the evolution of primary γ′ precipitates of each material using experimental data, the Thermo-Calc soft

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Bykov, Yu N., and T. F. Nurulina. "Sarcopenia: clinic, diagnosis, treatment, prevention (literature review)." Vestnik of North-Eastern Federal University. Medical Sciences, no. 2 (July 11, 2025): 12–22. https://doi.org/10.25587/2587-5590-2025-2-12-22.

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The strategic goal of the healthcare and social assistance system in the Russian Federation is increasing of human life expectancy. In this aspect, the importance of timely diagnosis and correction of conditions that occur in older people, one of which is sarcopenia, increases. The article presents an analysis of the current scientific literature on sarcopenia, methods of its diagnosis, treatment and prevention.Sarcopenia is characterized by a decrease of muscle tissue and strength as a result of the natural aging process of the body or in conditions of pathology. Primary sarcopenia is disting

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18

Bustamante, Yoselin Isabel Vallejo, and Oscar Fidel Antunez Martinez. "Honduran nursing care to pressure injuries in patients with invasive mechanical ventilation: A qualitative study." Belitung Nursing Journal 11, no. 1 (2025): 25–34. https://doi.org/10.33546/bnj.3592.

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Background: Although substantial evidence exists regarding the treatment of pressure ulcers, there is a lack of studies demonstrating a comprehensive nursing approach for managing pressure ulcers in the ICU, particularly among patients with invasive mechanical ventilation from developing countries like Honduras. This gap in research is significant as the risk and impact of pressure ulcers on health recovery cannot be disregarded. Objective: This study aimed to analyze Honduran nursing care for pressure ulcers in patients with invasive mechanical ventilation admitted to Intensive Care Units. Me

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Karimi Haresabadi, Azam, Fatemeh Mohammadi Shirmahaleh, Zohreh Rafezi, Marziyeh GholamiTooranposhti, and Parisa Peyvandi. "Presenting a Model of Co-Dependency in Women with Addicted Spouses based on their Self-Differentiation with the Mediating Role of Emotional Cognitive Regulation." Applied Family Therapy Journal 3, no. 1 (2022): 426–44. http://dx.doi.org/10.61838/kman.aftj.3.1.21.

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Aim: The aim of this study was to present a model of co-dependency in women with addicted spouses based on their differentiation with the mediating role of emotional cognitive regulation. Methods: The research method is cross-sectional correlation. The statistical population of this study consisted of all women with drug-addicted wives who referred to counseling centers, health centers and addiction treatment camps and meetings in Tehran in 1400, of which 188 people by cluster sampling they were selected in stages. In this study, tools of co-dependency (Span & Fisher, 1990), self-different

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Edmundson, Robert, Marilyn Byrne, and Eric D. Rankin. "Preliminary Outcome Data on a Model Treatment Group for Codependence." Alcoholism Treatment Quarterly 18, no. 1 (2000): 93–107. http://dx.doi.org/10.1300/j020v18n01_06.

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Hanna, Glenn J., Cesar Perez Batista, Alan L. Ho, et al. "Abstract CT253: A Phase 1/2 trial to evaluate the safety and antitumor activity of tipifarnib and alpelisib for patients with HRAS-overexpressing and/or PIK3CA-mutated/amplified recurrent/metastatic head and neck squamous cell carcinoma (The KURRENT trial)." Cancer Research 82, no. 12_Supplement (2022): CT253. http://dx.doi.org/10.1158/1538-7445.am2022-ct253.

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Abstract Background: Understanding connections between key cellular pathways is particularly important when selecting combinatorial cancer therapies. HRAS preferentially activates PI3K 5-fold more efficiently than KRAS, while KRAS is a more efficient activator of RAF (Yan et al. 1998). Further, mutant HRAS is insufficient for oncogenic transformation if it is unable to recruit PI3K in preclinical models (Gupta et al. 2007). Conversely, mutant PI3K requires RAS to drive tumor growth (Zhao and Vogt 2008). HRAS mutation/overexpression and PIK3CA mutations/amplifications account for up to 50% of h

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Baranok, N. "P.6.c.003 Treatment of codependence in relatives promotes abstinence in opiate addicts." European Neuropsychopharmacology 22 (October 2012): S400. http://dx.doi.org/10.1016/s0924-977x(12)70623-5.

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Brewer, Leslie G., Mary Lee Zawadski, and Rosamond Lincoln. "Characteristics of Alcoholics and Codependents Who Did and Did Not Complete Treatment." International Journal of the Addictions 25, no. 6 (1990): 653–63. http://dx.doi.org/10.3109/10826089009061326.

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Zhou, Xinyue, Lixia Zhang, Sajesan Aryal, et al. "Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia." Blood 142, Supplement 1 (2023): 587. http://dx.doi.org/10.1182/blood-2023-185353.

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Menin inhibitors that disrupt Menin-MLL interaction are candidate therapeutic agents for several acute myeloid leukemia (AML) subtypes such as KMT2A rearrangement and NPM1 mutation. Several Menin inhibitors are currently being assessed in clinical trials and have demonstrated promising initial results. However, the development of both innate and acquired resistance to Menin inhibitors could limit their therapeutic potential. While studies have found that around 40% of these resistance cases can be traced back to mutations in the Menin gene, the Menin gene remains unaltered in other majorities,

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Fein, George, Stan Smith, and David Greenstein. "Gait and Balance in Treatment-Naïve Active Alcoholics with and without a Lifetime Drug Codependence." Alcoholism: Clinical and Experimental Research 36, no. 9 (2012): 1550–62. http://dx.doi.org/10.1111/j.1530-0277.2012.01772.x.

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Shaikh, Anam, and Randy Lai. "Delusions of a Magic Man Shared by Codependent Twin Sisters." Case Reports in Psychiatry 2022 (May 13, 2022): 1–3. http://dx.doi.org/10.1155/2022/9126521.

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Folie à deux has been called double insanity or shared psychotic disorder. In this report, we describe the case of twin sisters who presented with identical delusions. Both sisters reported a “magic man” lived in their bodies and made them weak. Both underwent treatment with similar medications: the primary case with risperidone and the secondary case with paliperidone. The delusions of the primary case slowly abated with antipsychotics, whereas those of the secondary case completely resolved within a short duration after admission when the twins were separated in different hospital units.

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Voce, David J., Giovanna M. Bernal, Longtao Wu та ін. "Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma". Cancer Research 79, № 10 (2019): 2536–48. http://dx.doi.org/10.1158/0008-5472.can-18-2170.

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Byrne, Marilyn, Robert Edmundson, and Eric D. Rankin. "Symptom Reduction and Enhancement of Psychosocial Functioning Utilizing a Relational Group Treatment Program for Dependent/Codependent Population." Alcoholism Treatment Quarterly 23, no. 4 (2005): 69–84. http://dx.doi.org/10.1300/j020v23n04_05.

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Ghazisaeidi, Shahrzad, Milind M. Muley, and Michael W. Salter. "Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem." Annual Review of Pharmacology and Toxicology 63, no. 1 (2023): 565–83. http://dx.doi.org/10.1146/annurev-pharmtox-051421-112259.

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The study of chronic pain continues to generate ever-increasing numbers of publications, but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex-specific mechanisms underlying chronic pain has resulted in a surge of studies that include both sexes. A predominant focus has been on identifying sex differences, yet many newly identified cellular mechanisms and alterations in gene expression are conserved between the sexes. Here we review sex differences and similarities in cellular and molecular signals that drive the generation and resolution of neuropathic pain.

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Ghiță, Răzvan Eugen, Antonia Samia Khaddour, Gabriel Emanuel Dobre, et al. "DENTAL IMPLANT INSERTION – HOW TO PLAN AND PREDICT SUCCESS." Romanian Journal for Dental Research 1, no. 3 (2024): 35–48. http://dx.doi.org/10.58179/rjdr1303.

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For decades, implant placement protocols and implant loading protocols were addressed independently from one another. With the healing of the alveolar socket post-extraction, the implant placement protocol and the surgical technique are determining factors for selection of an appropriate implant loading protocol; these should be considered as codependent variables. The objectives of the study were to highlight factors influencing the implant placement and loading protocol. Material and methods. The retrospective study included patients presented for teeth extraction and oral rehabilitation tre

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Liu, Zhifa, Xiaobo Guo, Yuan Jiang, and Heping Zhang. "NCK2 Is Significantly Associated with Opiates Addiction in African-Origin Men." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/748979.

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Substance dependence is a complex environmental and genetic disorder with significant social and medical concerns. Understanding the etiology of substance dependence is imperative to the development of effective treatment and prevention strategies. To this end, substantial effort has been made to identify genes underlying substance dependence, and in recent years, genome-wide association studies (GWASs) have led to discoveries of numerous genetic variants for complex diseases including substance dependence. Most of the GWAS discoveries were only based on single nucleotide polymorphisms (SNPs)

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Šitum Čeprnja, Zdenka, Nela Kelam, Marin Ogorevc, et al. "Expression of LOXL3, NES, and SNAI1 in Melanoma Genesis and Progression." Cells 13, no. 17 (2024): 1450. http://dx.doi.org/10.3390/cells13171450.

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Melanoma is the most severe type of skin cancer and among the most malignant neoplasms in humans. With the growing incidence of melanoma, increased numbers of therapeutic options, and the potential to target specific proteins, understanding the basic mechanisms underlying the disease’s progression and resistance to treatment has never been more important. LOXL3, SNAI1, and NES are key factors in melanoma genesis, regulating tumor growth, metastasis, and cellular differentiation. In our study, we explored the potential role of LOXL3, SNAI1, and NES in melanoma progression and metastasis among p

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Tuffaha, H., and P. Scuffham. "PCN95 COST-EFFECTIVENESS ANALYSIS OF GERMLINE BRCA MUTATION TESTING AND OLAPARIB TREATMENT IN METASTATIC BREAST CANCER: AN EVALUATION OF CODEPENDENT TECHNOLOGIES." Value in Health 22 (November 2019): S454. http://dx.doi.org/10.1016/j.jval.2019.09.292.

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Pasek, Małgorzata, and Lilia Suchocka. "A Model of Social Support for a Patient–Informal Caregiver Dyad." BioMed Research International 2022 (October 4, 2022): 1–13. http://dx.doi.org/10.1155/2022/4470366.

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Background. Close persons (informal caregivers) are the most important providers of support indicated by cancer patients. Cancer affects couples as a codependent system. The aim of this study was to investigate the factors influencing the multidimensional aspect of social support in a cancer patient–informal caregiver dyad. Methods. The research project was cross-sectional. The diagnostic survey method and the survey technique were used. The study was conducted using standardised research tools: BSSS, POS, SSCS, TIPI, ET, SPT, and the authors’ own tool for sociodemographic assessment. Results.

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Shishkova, Alexandra M., and Victor V. Bocharov. "The Burnout Concept as a Theoretical Framework for Investigating the Caregiving Impact of Relatives of Patients with Addictive Disorders." Psychology in Russia: State of the Art 15, no. 4 (2022): 111–32. http://dx.doi.org/10.11621/pir.2022.0307.

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Background. Relatives of patients with addictive disorders often face significant difficulties in their daily lives. Although the burnout concept is currently considered a significant and promising theoretical framework for studying family members who care for chronically ill patients, its application has encountered considerable difficulties in the area of addiction treatment. Objective. This article explores the methodology for studying the psychological issues arising in families affected by addictive disorders. We analyzed the social, economic, and cultural conditions of the different stud

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Holloway, Minita G., Ekaterina V. Laz та David J. Waxman. "Codependence of Growth Hormone-Responsive, Sexually Dimorphic Hepatic Gene Expression on Signal Transducer and Activator of Transcription 5b and Hepatic Nuclear Factor 4α". Molecular Endocrinology 20, № 3 (2006): 647–60. http://dx.doi.org/10.1210/me.2005-0328.

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Abstract Targeted disruption of the signal transducer and activator of transcription 5b gene (STAT5b) leads to decreased expression in male mouse liver of a male-predominant cytochrome (Cyp) 2d protein, whereas female-predominant Cyp2b proteins are increased. Presently, we characterize the effects of STAT5b deficiency on 15 specific, individual Cyp RNAs and other sexually dimorphic liver gene products. All seven male-specific RNAs investigated were decreased to normal female levels in STAT5b-deficient male liver, whereas five of eight female-specific RNAs, designated class I female genes, were

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D'Arcangelo, G., R. Habas, S. Wang, S. Halegoua, and S. R. Salton. "Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras." Molecular and Cellular Biology 16, no. 9 (1996): 4621–31. http://dx.doi.org/10.1128/mcb.16.9.4621.

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Nerve growth factor (NGF) treatment of PC12 cells leads to the elaboration of a neuronal phenotype, including the induction of neuronally expressed genes such as vgf. To study vgf transcription, we have created chimeric vgf/beta-globin genes in which vgf promoter sequences drive the expression of the beta-globin reporter gene or of a chimeric beta-globin gene fused to 3' untranslated vgf gene sequences. We have found that the level of inducibility of the latter construct by NGF resembles that of the endogenous vgf gene. Using transient transfection of the chimeric reporter genes into PC12 cell

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Vojtikiv-Samoilovska, Danijela, and Anita Arsovska. "Prevalence and Predictors of Depression after Stroke - Results from a Prospective Study." Open Access Macedonian Journal of Medical Sciences 6, no. 5 (2018): 824–28. http://dx.doi.org/10.3889/oamjms.2018.182.

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BACKGROUND: A depression following a stroke (Post Stoke Depression-PSD) is the most common complication of a stroke that has a negative effect on the result after the stroke. A better definition of the risk factors of the disease will provide for better prediction and treatment.AIM: To research identification of the risk factors for PSD, typical for the Macedonian population, which will help in early prediction, timely diagnosis and treatment of the disease?MATERIAL AND METHODS: We carried out a prospective study in order to determine the prevalence and the risk factors of PSD in 100 patients

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Смирнова, Н. Н., А. Г. Соловьев, and Н. И. Смирнов. "The Role of Social Resources in Psychological Assistance of Narcological Patients Treatment and Rehabilitation." Психиатрия, психотерапия и клиническая психология, no. 3 (November 21, 2022): 352–59. http://dx.doi.org/10.34883/pi.2022.13.3.012.

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Процесс лечения и социально-психологической реабилитации лиц с наркологическими заболеваниями протекает под влиянием целого комплекса объективных и субъективных факторов. Целенаправленное воздействие на субъективные факторы позволяет улучшить качество организации лечебно-реабилитационного процесса с активным привлечением социально-психологических ресурсов. Цель работы – систематизация роли социально-психологических ресурсов на микро-, мезо- и макросоциальном уровнях оказания лечебно-реабилитационной помощи наркологическим пациентам. Показано, что направленность системы здравоохранения и иных о

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Housley, Stephen Nick, Paul Nardelli, Allison B. Wang, Ann Marie Flores, Eric J. Perreault, and Tim Cope. "Cancer's role in chemotherapy-induced neuropathy." Journal of Clinical Oncology 38, no. 15_suppl (2020): e24064-e24064. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24064.

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e24064 Background: For the constellation of neurological disorders known as chemotherapy-induced neuropathy, mechanistic understanding, and treatment remain deficient. This might be due to the fact that studies on the effects of chemotherapies on the nervous system have utilized experimental models that exclude cancer perhaps due to the presumption that chemotherapy alone explains the neuropathology. However, the convergence of cancer and chemotherapy on the same biological processes seems likely to yield non-linear interactions. This led us to hypothesize that clinically relevant neuropathy e

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Rojas Puentes, Luis Leonardo, Alejandro Ruiz-Patiño, Diana Carolina Mayorga, et al. "Histopathological prognostic markers in metastatic lung adenocarcinoma, validation of stromal fibrosis and immunoscore as easy to interpret findings and their correlation with survival." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21566-e21566. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21566.

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e21566 Background: Several histopathological markers have been associated with immune system activity and its relationship with clinical outcomes in lung cancer. Determination of tumor infiltrating lymphocytes as well as specific subpopulations could reveal cytotoxic potential. Additionally, changes in stromal composition and fibrosis could also reflect potential cellular interactions with the tumor lesions. In this study we validate these two findings as potential prognostic factors. Methods: A retrospective cohort analysis of patients with advanced lung adenocarcinoma treated in a reference

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Hameed, Maha, Gustavo Garcia, Laiba Yaseen, et al. "Cancer Survivorship in Gulf Countries: An Updated Systematic Review." Blood 142, Supplement 1 (2023): 7276. http://dx.doi.org/10.1182/blood-2023-189517.

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Introduction Cancer survivorship addresses attendant challenges beyond treatment, emphasizing outcomes of patient quality of life, costs, emergency services/hospitalization, and mortality. Nekhlyduov L et al., 2019 describe nine domains of cancer survivorship which, although represented distinctly, are interrelated and codependent. Despite the sustained worldwide increase in the burden of cancer in the past decade, there is a paucity of evidence regarding cancer survivorship pertaining to patient needs across the Gulf countries. Methods A systematic review adhering to the PRISMA 2020 guideline

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Subramanyam, M., M. Prakash Appaya, U. C. Samudyatha, S. Preeti, and Mahesh Gowda. "“I Don’t Mind Them Drinking, as Long as…”: A Cross-sectional Study to Identify Codependence among Primary Caregivers of Patients with Alcohol Dependence in Urban India." Indian Journal of Social Psychiatry, April 20, 2024. http://dx.doi.org/10.4103/ijsp.ijsp_172_23.

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Abstract Background: Codependence is a form of relationship addiction, described as a “disease of lost selfhood.” Codependence among primary caregivers adversely impacts treatment outcomes in Alcohol Dependence Syndrome (ADS) patients. Personality traits of the caregiver may also influence codependency and its severity. However, in routine clinical practice, codependence among primary caregivers of alcoholic patients is not assessed and addressed. This study aimed to identify codependence among caregivers of ADS patients and determine its association with personality traits in various subgroup

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Peixoto da Silva, Michele, Adriane Maria Netto de Oliveira, Priscila Arruda da Silva, Simone Algeri, and Maria Cristina Flores Soares. "Family orientation group as a strategy for care in chemical codependency." Investigación y Educación en Enfermería 37, no. 3 (2019). http://dx.doi.org/10.17533/udea.iee.v37n3e08.

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Objective. To determine the importance of the family support group in the treatment of codependency, based in reports made by relatives of a therapeutic community for drug addicts. Methods. Study conducted in a therapeutic community for alcohol and other drug addicts in a city in the southern extreme of Brazil. This is a qualitative, exploratory and descriptive research with eight drug addict relatives. Data collection occurred through semi-structured interviews and the use of a field diary, focusing on the family orientation group as a space for the health promotion of family members of psych

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BAPTISTA, Heloisa Praça, Cassandra Borges BORTOLON, Taís de Campos MOREIRA, and Helena Maria Tannhauser BARROS. "Investigation of factors associated with low adherence to treatment of codependency in family members of psychoactive substance users." Estudos de Psicologia (Campinas) 38 (2021). http://dx.doi.org/10.1590/1982-0275202138e200023.

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Abstract The aim of this study was to investigate possible factors that prevent adherence to the treatment of codependent family members of problem drug use individuals. A quasi-experimental study was carried out with 133 relatives of psychoactive substances users who called the Brazilian drug hotline (Ligue 132) between 2013 and 2015, from the five regions of Brazil. The following instruments were used: General service protocol; Family assistance protocol; Holyoake Codependency Index; Behavioral Adherence Scale; and Adherence Factor Questionnaire. Univariate analysis of data was performed for

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Dias, Leone Mendes, Marcelo da Silva Alves, Maria Odete Pereira, Laércio Deleon de Melo, Camila Cristina Gregório de Assis, and Thelma Spindola. "Health personnel, family relationships and codependency of psychoactive substances: a phenomenological approach." Revista Brasileira de Enfermagem 74, no. 1 (2021). http://dx.doi.org/10.1590/0034-7167-2020-0309.

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ABSTRACT Objectives: to reflect on the daily life of family members dependent on psychoactive substances and the role of health professionals in Primary Care. Methods: a descriptive investigation outlined in Maffesoli’s phenomenological approach, carried out at a Basic Health Unit in Minas Gerais with eight family members dependent on psychoactive substances. Sociodemographic characterization data and in-depth interviews were collected and analyzed with support of NVivo Pro11® software. All ethical and legal aspects were met. Results: physicians were the professionals most mentioned in partici

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García-Sanz, Ramón, María García-Álvarez, Alejandro Medina, et al. "Clonal architecture and evolutionary history of Waldenström's macroglobulinemia at the single-cell level." Disease Models & Mechanisms, July 26, 2023. http://dx.doi.org/10.1242/dmm.050227.

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To provide insight into the subclonal architecture and codependency patterns of the alterations in Waldenström's macroglobulinemia (WM), we performed single-cell mutational and protein profiling of eight patients. A custom panel was designed to screen for mutations and copy number alterations at the single-cell level in samples taken from patients at diagnosis (n=5) or at disease progression (n=3). Results showed that in asymptomatic WM at diagnosis, MYD88L265P was the predominant clonal alteration, while other events, if present, were secondary and subclonal to MYD88L265P. In symptomatic WM,

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Housley, Stephen N., Paul Nardelli, Travis M. Rotterman, J’Ana Reed, and Timothy C. Cope. "Mechanosensory encoding dysfunction emerges from cancer-chemotherapy interaction." Frontiers in Molecular Biosciences 9 (November 24, 2022). http://dx.doi.org/10.3389/fmolb.2022.1017427.

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Persistent sensory, motor and cognitive disabilities comprise chemotherapy-induced neural disorders (CIND) that limit quality of life with little therapeutic relief for cancer survivors. Our recent preclinical study provides new insight into a condition impacting the severity of chronic CIND. We find that sensorimotor disability observed following cancer treatment exceeds that attributable to chemotherapy alone. A possible explanation for intensified disability emerged from evidence that codependent effects of cancer and chemotherapy amplify defective firing in primary sensory neurons supplyin

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"Расчетные методы оценки ударной вязкости сварных элементов с трещинами". Вестник Инженерной школы ДВФУ 44, № 3 (2020): 22–36. http://dx.doi.org/10.24866/2227-6858/2020-3-3.

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Практика показывает, что для сварных конструкций, эксплуатируемых в условиях Крайнего Севера необходимо уделять внимание работоспособности сварных соединений при низких температурах. Металл сварных соединений в процессе воздействия обработки изменяет свои свойства, снижается ударная вязкость, образуется гетерогенная структура с большой степенью разнозернистости. Чтобы оценивать и иметь возможность правильно контролировать термическое воздействие и последствия сварочного процесса, требуется решить задачу аналитического определения ударной вязкости для всех зон сварного соединения. В настоящей с

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Teppala, Srinivas, Paul A. Scuffham, and Haitham Tuffaha. "The cost-effectiveness of germline BRCA testing-guided olaparib treatment in metastatic castration resistant prostate cancer." International Journal of Technology Assessment in Health Care 40, no. 1 (2024). http://dx.doi.org/10.1017/s0266462324000011.

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Abstract Background Olaparib targets the DNA repair pathways and has revolutionized the management of metastatic castration resistant prostate cancer (mCRPC). Treatment with the drug should be guided by genetic testing; however, published economic evaluations did not consider olaparib and genetic testing as codependent technologies. This study aims to assess the cost-effectiveness of BRCA germline testing to inform olaparib treatment in mCRPC. Methods We conducted a cost-utility analysis of germline BRCA testing-guided olaparib treatment compared to standard care without testing from an Austra

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