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Chen, Haisong, Zengjie Wu, Wenjian Xu, et al. "Evaluating the Scope of Malignant Bone Tumor Using ADC Measurement on ADC Map." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381985326. http://dx.doi.org/10.1177/1533033819853267.

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Background: It is very important for surgeons to know the accurate borders of malignant bone tumors before they can precisely resect the tumors. The objective of the study is to investigate the usefulness of apparent diffusion coefficient value for estimating the extent of malignant bone tumor. Methods: VX2 tumor fragments were implanted into the tibiae of 30 rabbits. After 4 weeks, magnetic resonance plain scans were performed and then tumor specimens were cut into sagittal sections and partitioned into histology slices for dot-to-dot comparisons with microscopic findings. The sizes of the tu
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Buss, Arvids, Maija Radzina, Mara Liepa, et al. "Role of Apparent Diffusion Coefficient Value and Apparent Diffusion Coefficient Ratio as Prognostic Factors for Prostate Cancer Aggressiveness." Diagnostics 14, no. 21 (2024): 2438. http://dx.doi.org/10.3390/diagnostics14212438.

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Background: Prostate cancer is one of the most prevalent cancers in the male population. To determine the aggressiveness of suspected lesions precisely, predictive models are increasingly being developed using quantitative MRI measurements, and particularly the ADC value. This study aimed to determine whether ADC values could be used to establish the aggressiveness of prostate cancer. Methods: A retrospective single-center study included 398 patients with prostate cancer who underwent a multiparametric MRI prior to radical prostatectomy. DWI ADC values were measured (µm2/s) using b values of 5
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Teixeira, Sara Reis, Paula Condé Lamparelli Elias, Andrea Farias de Melo Leite, Tatiane Mendes Gonçalves de Oliveira, Valdair Francisco Muglia, and Jorge Elias Junior. "Apparent diffusion coefficient of normal adrenal glands." Radiologia Brasileira 49, no. 6 (2016): 363–68. http://dx.doi.org/10.1590/0100-3984.2015.0045.

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Abstract Objective: To assess the feasibility and reliability of apparent diffusion coefficient (ADC) measurements of normal adrenal glands. Materials and methods: This was a retrospective study involving 32 healthy subjects, divided into two groups: prepubertal (PreP, n = 12), aged from 2 months to 12.5 years (4 males; 8 females); and postpubertal (PostP, n = 20), aged from 11.9 to 61 years (5 males; 15 females). Diffusion-weighted magnetic resonance imaging (DW-MRI) sequences were acquired at a 1.5 T scanner using b values of 0, 20, 500, and 1000 s/mm2. Two radiologists evaluated the images.
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Sumikawa, Tetsuo, Hidetake Yabuuchi, Chiharu Sumikawa, Yoshiteru Nakashima, and Gouji Miura. "Influence of blade width and magnetic field strength on the ADC on PROPELLER DWI in head and neck." Neuroradiology Journal 33, no. 1 (2019): 39–47. http://dx.doi.org/10.1177/1971400919870178.

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Purpose The purpose of this study was to investigate the influence of blade width and magnetic field strength on apparent diffusion coefficient values of periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) diffusion-weighted imaging in the head and neck at 1.5 and 3.0 T magnetic resonance imaging. Methods Fifteen healthy volunteers (eight men and seven women; mean age 36.4 ± 10.1 years) underwent PROPELLER diffusion-weighted imaging using four blade widths at 3.0 T and three blade widths at 1.5 T. For the multigroup comparison of apparent diffusion coeffici
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Wang, Rui, Weidong Liu, Fang Ren, and Jing Ren. "Comparative study of diagnostic value between IVIM and DWI for prostate cancer at 3.0 T magnetic resonance." Chinese Journal of Academic Radiology 4, no. 3 (2021): 186–93. http://dx.doi.org/10.1007/s42058-021-00079-x.

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Abstract Objective To quantitatively compare the diagnostic and differential diagnostic value of intra-voxel incoherent motion imaging (IVIM) and diffusion weighted imaging (DWI) for prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods 68 cases of prostate confirmed by pathology, including 33 cases of PCa and 35 cases of BPH were analyzed retrospectively. All patients were underwent T1WI, T2WI, DWI and IVIM sequences to obtain the apparent diffusion coefficient (ADC), pure apparent diffusion coefficient (Pure-ADC/D), standard apparent diffusion coefficient (standard-ADC/Ds), f
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Ignjatovic, Jelena, Dragan Stojanov, Vladimir Zivkovic, et al. "Apparent diffusion coefficient in the evaluation of cerebral gliomas malignancy." Vojnosanitetski pregled 72, no. 10 (2015): 870–75. http://dx.doi.org/10.2298/vsp140229073i.

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Background/Aim. Magnetic resonance imaging (MRI) is a key modality not only for lesion diagnosis, but also to evaluate the extension, type and grade of the tumor. Advanced MRI techniques provide physiologic information that complements the anatomic information available from conventional MRI. The aim of this study was to determine whether there is a correlation between apparent diffusion coefficient (ADC) maps of intracranial glial tumors and histopathologic findings and whether ADCs can reliably distinguish lowgrade from high-grade gliomas. Methods. This retrospective study included 25 patien
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Usuda, Katsuo, Shun Iwai, Aika Yamagata, et al. "How to Discriminate Lung Cancer From Benign Pulmonary Nodules and Masses? Usefulness of Diffusion-Weighted Magnetic Resonance Imaging With Apparent Diffusion Coefficient and Inside/Wall Apparent Diffusion Coefficient Ratio." Clinical Medicine Insights: Oncology 15 (January 2021): 117955492110148. http://dx.doi.org/10.1177/11795549211014863.

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Background: Although diffusion-weighted imaging (DWI) is useful for differential diagnosis between lung cancers and benign pulmonary nodules and masses (BPNMs), it is difficult to differentiate pulmonary abscesses from lung cancers because pulmonary abscesses show restricted diffusion. With this research we will present how to assess the total apparent diffusion coefficient (ADC) and inside/wall ADC ratio for these pulmonary nodules and masses (PNMs). Methods: The pulmonary lesions were divided into next 3 groups. There were 40 lung cancers, 41 inflammatory benign PNMs (mycobacteria disease 13
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Sağlam, SY, F. Kökcü, and ME Çeker. "Importance of Apparent Diffusion Coefficient in Differentiation of Cerebral Tumors." Nigerian Journal of Clinical Practice 28, no. 5 (2025): 608–14. https://doi.org/10.4103/njcp.njcp_853_24.

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Background: Diffusion-weighted magnetic resonance imaging (MRI) is an advanced functional imaging method based on the molecular motion of water. The diffusion of the water molecules in the tissue is dependent on a number of factors. One factor that modulates the diffusion of water molecules is the cell density in the tissue and the nuclear/cytoplasmic volume ratio, which is often increased in high-grade tumors. Aim: In line with this information, the present study aimed to investigate the role of apparent diffusion coefficient (ADC) values in the differential diagnosis of brain tumors and to d
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Kanamoto, Hirohito, Masaki Norimoto, Yawara Eguchi, et al. "Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging." Asian Spine Journal 14, no. 3 (2020): 312–19. http://dx.doi.org/10.31616/asj.2019.0266.

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Study Design: Observational study.Purpose: To evaluate healthy volunteers and patients with spinal canal lesions using apparent diffusion coefficient (ADC) maps with diffusion-weighted imaging.Overview of Literature: Decompression surgery for lumbar spinal stenosis (LSS) is selected on the basis of subjective assessment and cross-sectional magnetic resonance imaging (MRI). However, there is no objective standard for this procedure.Methods: We performed 3T MRI in 10 healthy volunteers and 13 patients with LSS. The ADC values in the spinal canal were evaluated at 46 vertebrae (L4/5 and L5/S1 for
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Basirjafari, Sedigheh, Masoud Poureisa, Babak Shahhoseini, et al. "Apparent diffusion coefficient values and non-homogeneity of diffusion in brain tumors in diffusion-weighted MRI." Acta Radiologica 61, no. 2 (2019): 244–52. http://dx.doi.org/10.1177/0284185119856887.

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Background The values that have been received from apparent diffusion coefficient (ADC) maps of diffusion-weighted magnetic resonance imaging (DW-MRI) might play a vital role in evaluating tumors and their grading scale. Purpose To investigate the predictive role of this heterogeneity in brain tumor pathologies and its correlation with Ki-67. Material and Methods A total of 124 patients with brain tumors underwent brain MRI with gadolinium injection. ADC and standard deviation of each lesion have been obtained from manual localization of the region of interest on the ADC map. A receiver operat
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Sahoo, Prativa, Russell C. Rockne, Alexander Jung, Pradeep K. Gupta, Ram K. S. Rathore, and Rakesh K. Gupta. "Synthetic Apparent Diffusion Coefficient for High b-Value Diffusion-Weighted MRI in Prostate." Prostate Cancer 2020 (February 10, 2020): 1–7. http://dx.doi.org/10.1155/2020/5091218.

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Purpose. It has been reported that diffusion-weighted imaging (DWI) with ultrahigh b-value increases the diagnostic power of prostate cancer. DWI with higher b-values is challenging as it commonly suffers from low signal-to-noise ratio (SNR), distortion, and longer scan time. The aim of our study was to develop a technique for quantification of apparent diffusion coefficient (ADC) for higher b-values from lower b-value DW images. Materials and Methods. Fifteen patients (7 malignant and 8 benign) were included in this study retrospectively with the institutional ethical committee approval. All
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Verbanck, Sylvia, and Manuel Paiva. "Acinar determinants of the apparent diffusion coefficient for helium-3." Journal of Applied Physiology 108, no. 4 (2010): 793–99. http://dx.doi.org/10.1152/japplphysiol.01230.2009.

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The apparent diffusion coefficient (ADC) obtained by helium-3 magnetic resonance imaging over several seconds is thought to reflect diffusion impairment due to both intra- and interacinar structure. In this study, numerical simulations of intra-acinar gas mixing and effective diffusion were performed in a multiple-branch-point model of the human acinus. Using a previously described method, we computed the instantaneous effective diffusion resulting from the diffusive impairment imposed by intra-acinar branching for varying times up to 5 s. We also tested the influence on effective diffusion of
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Gwak, Dong-Seok, WooChan Choi, Dong-Hyun Shim, et al. "Role of Apparent Diffusion Coefficient Gradient Within Diffusion Lesions in Outcomes of Large Stroke After Thrombectomy." Stroke 53, no. 3 (2022): 921–29. http://dx.doi.org/10.1161/strokeaha.121.035615.

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Background and Purpose: The outcome of endovascular treatment in stroke patients with a large ischemic core is not always satisfactory. We evaluated whether the severity of baseline diffusion-weighted imaging abnormalities, as assessed by different apparent diffusion coefficient (ADC) thresholds, correlates with the clinical outcome in these patients after successful endovascular treatment. Methods: In 82 consecutive patients with a large vessel occlusion in the anterior circulation admitted ≤24 hours after onset, a baseline diffusion lesion volume (ADC ≤620×10 −6 mm 2 /s [ADC 620 ]) ≥50 mL an
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Park, Ga Eun, Sung Hun Kim, Eun Jeong Kim, Bong Joo Kang, and Mi Sun Park. "Histogram analysis of volume-based apparent diffusion coefficient in breast cancer." Acta Radiologica 58, no. 11 (2017): 1294–302. http://dx.doi.org/10.1177/0284185117694507.

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Background Breast cancer is a heterogeneous disease. Recent studies showed that apparent diffusion coefficient (ADC) values have various association with tumor aggressiveness and prognosis. Purpose To evaluate the value of histogram analysis of ADC values obtained from the whole tumor volume in invasive ductal cancer (IDC) and ductal carcinoma in situ (DCIS). Material and Methods This retrospective study included 201 patients with confirmed DCIS (n = 37) and IDC (n = 164). The IDC group was divided into two groups based on the presence of a DCIS component: IDC–DCIS (n = 76) and pure IDC (n = 8
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Utomo, Sri Andreani, Abdul Hafid Bajamal, Yuyun Yueniwati Prabowowati Wadjib, Irwan Barlian Immadoel Haq, Vivid Umu Varidha, and Dyah Fauziah. "The role of apparent diffusion coefficient in differentiating typical from atypical meningioma." Bali Medical Journal 11, no. 1 (2022): 455–59. http://dx.doi.org/10.15562/bmj.v11i1.3244.

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Background: Differentiation of typical from atypical meningiomas would greatly improve surgical planning and further treatment options. Appparent diffusion coefficient (ADC) has the potential to characterize meningioma subtypes. This study aimed to assess the value of ADC in differentiating typical and atypical meningiomas. Method: A retrospective study was conducted using medical records at RSUD Dr. Soetomo Surabaya in January 2019 – September 2021. ADC values were obtained by placing three ROIs on tumors. We used receiver operating curve (ROC) analysis to determine the optimal cut-off ADC va
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Hruşcã, Adrian, Andreea Liana Rãchişan, Siegfried Rödl, and Erich Sorantin. "Can Apparent Diffusion Coefficient Predict the Clinical Outcome in Drowned Children?" Canadian Association of Radiologists Journal 68, no. 2 (2017): 217–23. http://dx.doi.org/10.1016/j.carj.2016.12.001.

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Introduction Pediatric cerebral hypoxic-ischemic injury frequently results in severe neurological outcome. Imaging with diffusion-weighted magnetic resonance imaging (DWi) demonstrates that the acute cerebral injury and apparent diffusion coefficient (ADC) allow the assessment of the severity of brain damage. The main objective was to examine if spatial distribution of reductions in ADC values is associated with clinical outcome in drowned children. Methods This is a retrospective study of 7 children (7 examinations) suffering from a hypoxic-ischemic event who underwent DWi. Seven subjects wit
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Klose, Uwe, Marion Batra, and Thomas Nägele. "Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/373716.

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Purpose. The distribution of apparent diffusion coefficient (ADC) values in the brain can be used to characterize age effects and pathological changes of the brain tissue. The aim of this study was the parameterization of the whole brain ADC histogram by an advanced model with influence of age considered.Methods. Whole brain ADC histograms were calculated for all data and for seven age groups between 10 and 80 years. Modeling of the histograms was performed for two parts of the histogram separately: the brain tissue part was modeled by two Gaussian curves, while the remaining part was fitted b
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Lucarelli, Nicola Maria, Ilaria Villanova, Nicola Maggialetti, et al. "Quantitative ADC: An Additional Tool in the Evaluation of Prostate Cancer?" Journal of Personalized Medicine 13, no. 9 (2023): 1378. http://dx.doi.org/10.3390/jpm13091378.

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Prostate cancer is one of the most common tumors among the male population. Magnetic resonance imaging (MRI), standardized by the PI-RADS version 2.1 scoring system, has a fundamental role in detecting prostate cancer and evaluating its aggressiveness. Diffusion-weighted imaging sequences and apparent diffusion coefficient values, in particular, are considered fundamental for the detection and characterization of lesions. In 2016 the International Society of Urological Pathology introduced a new anatomopathological 5-grade scoring system for prostate cancer. The aim of this study is to evaluat
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Xing, Da, Nikolaos G. Papadakis, Christopher L. H. Huang, Vee Meng Lee, T. Adrian Carpenter, and Laurance D. Hall. "Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain." Magnetic Resonance Imaging 15, no. 7 (1997): 771–84. http://dx.doi.org/10.1016/s0730-725x(97)00037-4.

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Evans, Andrea, David G. McCormack, Giles Santyr, and Grace Parraga. "Mapping and quantifying hyperpolarized 3He magnetic resonance imaging apparent diffusion coefficient gradients." Journal of Applied Physiology 105, no. 2 (2008): 693–99. http://dx.doi.org/10.1152/japplphysiol.00178.2008.

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We measured hyperpolarized 3He magnetic resonance imaging (MRI) apparent diffusion coefficients (ADC) and quantified ADC gradients in each three-by-three voxel region of interest (ROI). Such local ADC gradients can be represented in vector maps showing the magnitude (| G3×3|) and direction of ADC gradients, providing a qualitative visualization tool and quantitative measurement of airway and air space heterogeneity. Twenty-four subjects (15 male, mean age = 67 ± 7 yr) with global initiative for chronic obstructive lung disease (GOLD) stage II ( n = 9, mean age 68 ± 6 yr), GOLD stage III chroni
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Bušić, Marija, Zoran Rumboldt, Dora Čerina, Željko Bušić, and Krešimir Dolić. "Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas." Cancers 16, no. 4 (2024): 681. http://dx.doi.org/10.3390/cancers16040681.

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This study aimed to evaluate potential posttreatment changes in ADC values within the tissue surrounding the enhancing lesion, particularly in areas not exhibiting MRI characteristics of involvement. Additionally, the objective was to investigate the correlations among ADC values, treatment response, and survival outcomes in individuals diagnosed with gliomas. This retrospective study included a total of 49 patients that underwent either stereotactic biopsy or maximal surgical resection. Histologically confirmed as Grade III or IV gliomas, all cases adhered to the 2016 and 2021 WHO classificat
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Mustofa, Ali, Anggraini Dwi Sensusiati, Muhaimin Muhaimin, Sri Andreani Utomo, and Risalatul Latifah. "ANALYSIS OF FRACTIONAL ANISOTROPY (FA) VALUES AND APPARENT DIFFUSION COEFFICIENT (ADC) VALUES IN ISCHEMIC STROKE DISEASES OF MRI GE 3 TESLA." Journal Of Vocational Health Studies 2, no. 3 (2019): 107. http://dx.doi.org/10.20473/jvhs.v2.i3.2019.107-111.

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Background: Diffusion Weighted Imaging and Diffusion Tensor Imaging is an advanced technique in MRI that shows the diffusion in brain of ischemic stroke disease. Diffusion Weighted Imaging (DWI) shows the lesions without gadolinium contrast agent and produce Apparent Diffusion Coefficient values. Whereas, Diffusion Tensor Imaging (DTI) shows connectivity’s of central nervous system that cannot be seen by using conventional MRI. Diffusion Tensor Imaging produces Fractional Anisotropy values. Purpose:This study has aim to analyze the Apparent Diffusion Coefficient values and Fractional Anisotrop
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Gihr, Georg, Diana Horvath-Rizea, Elena Hekeler, et al. "Diffusion weighted imaging in high-grade gliomas: A histogram-based analysis of apparent diffusion coefficient profile." PLOS ONE 16, no. 4 (2021): e0249878. http://dx.doi.org/10.1371/journal.pone.0249878.

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Purpose Glioblastoma and anaplastic astrocytoma represent the most commonly encountered high-grade-glioma (HGG) in adults. Although both neoplasms are very distinct entities in context of epidemiology, clinical course and prognosis, their appearance in conventional magnetic resonance imaging (MRI) is very similar. In search for additional information aiding the distinction of potentially confusable neoplasms, histogram analysis of apparent diffusion coefficient (ADC) maps recently proved to be auxiliary in a number of entities. Therefore, our present exploratory retrospective study investigate
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Elysanti Dwi Martadiani, I Wayan Juli Sumadi, I Wayan Gede Artawan Eka Putra, Jonathan Andryanto, Anak Agung Gede Agung Priyastana, and Felicia Nike. "Characteristics and Role of Apparent Diffusion Coefficient (ADC) Value in Musculoskeletal Soft Tissue Tumor." Indonesia Journal of Biomedical Science 17, no. 2 (2023): 289–94. http://dx.doi.org/10.15562/ijbs.v17i2.512.

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Introduction: Musculoskeletal soft tissue tumors (STTs) consist of a group of malignant and benign tumors that present challenges in diagnosis and therapy. Adding diffusion-weighted imaging and apparent diffusion coefficient (DWI/ADC) ​​provides tissue characteristics that are different from those obtained by conventional MR techniques. Quantitative examination of the diffusion of water molecules in tissue is expressed as ADC value, which is expected to be more helpful in differentiating malignant and benign soft tissue masses. This study was carried out to determine the characteristics and ro
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McPartlin, Andrew, Lucy Kershaw, Alan McWilliam, et al. "Changes in prostate apparent diffusion coefficient values during radiotherapy after neoadjuvant hormones." Therapeutic Advances in Urology 10, no. 12 (2018): 359–64. http://dx.doi.org/10.1177/1756287218798748.

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Background: Changes in prostate cancer apparent diffusion coefficient (ADC) derived from diffusion-weighted magnetic resonance imaging (MRI) provide a noninvasive method for assessing radiotherapy response. This may be attenuated by neoadjuvant hormone therapy (NA-HT). We investigate ADC values measured before, during and after external beam radiotherapy (EBRT) following NA-HT. Methods: Patients with ⩾T2c biopsy-proven prostate cancer receiving 3 months of NA-HT plus definitive radiotherapy were prospectively identified. All underwent ADC-MRI scans in the week before EBRT, in the third week of
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Barham, Majd, Masahiro Kuroda, Yuuki Yoshimura, et al. "Evaluation of calculation processes of apparent diffusion coefficient subtraction method (ASM) imaging." PLOS ONE 18, no. 2 (2023): e0282462. http://dx.doi.org/10.1371/journal.pone.0282462.

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A number of restricted diffusion (RD) imaging techniques, such as diffusion kurtosis (DK) imaging and Q space imaging, have been developed and proven to be useful for the diagnosis of diseases, including cerebral gliomas and cerebrovascular infarction. In particular, apparent diffusion coefficient (ADC) subtraction method (ASM) imaging has become available recently as a novel RD imaging technique. ASM is based on the difference between the ADC values in an image pair of two ADC maps, ADC basic (ADCb) and ADC modify (ADCm), which are created from diffusion-weighted images taken using short and
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Ranabhat, Kajan, Suresh Bishokarma, Pratyush Shrestha, Rajesh Panth, and Ram Kumar Ghimire. "Role of Quantitative Apparent Diffusion Coefficient in Predicting Genetic Subtypes of Gliomas." Nepal Journal of Neuroscience 17, no. 3 (2020): 4–11. http://dx.doi.org/10.3126/njn.v17i3.33115.

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Introduction: Magnetic resonance morphologic features are widely used in characterising gliomas for predicting grades and thereby aiding in preoperative management planning. We aim to find out if Magnetic Resonance Imaging (MRI) morphologic characters and quantitative apparent diffusion coefficient (ADC) measurements can predict genetic subtypes of high-grade gliomas.
 Methods and Materials: Preoperative MRI examinations of histopathologically proven gliomas were retrospectively studied for qualitative tumor characteristics, including location, extent, cortical involvement, margin sharpne
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Thakur, Supriya Suresh, Aruna Vinchurkar, Vaishali Wadekar, and Ajay Irmale. "Diffusion-Weighted MRI for Intracranial Tumor Differentiation: Analyzing the Role of Apparent Diffusion Coefficient Values." Journal of Medical and Dental Science Research 11, no. 10 (2024): 84–87. http://dx.doi.org/10.35629/076x-11108487.

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Magnetic Resonance Imaging (MRI) has become a standard non-invasive method for evaluating brain lesions, offering highly detailed structural data. However, traditional MRI faces limitations in differentiating between various tumor components, peritumoral edema, and healthy brain tissue. Diffusion-Weighted Imaging (DWI), an advanced MRI modality, overcomes some of these challenges by measuring water molecule movement within tissues, providing additional insights for precise tumor evaluation. This study explores the diffusion characteristics of intracranial tumor components using DWI. Forty pati
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Mahabir, Yadav, Mohapatra Manoranjan, Das Swati, et al. "Role of Diffusion Weighted Imaging (DWI) & Apparent Diffusion Coefficient (ADC) In Differentiation between Benign and Malignant Neck Masses." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 12–20. https://doi.org/10.5281/zenodo.14030434.

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<strong>Objectives:&nbsp;</strong>The present study was to evaluate the accuracy of ADC in differentiating benign from malignant neck masses. And, to compare the MRI findings and ADC values with histopathological findings.&nbsp;<strong>Methods:&nbsp;</strong>After the demographic data collection was completed, the patients were then made to undergo MRI study, using GE Signa HDxT 1.5 Tesla MRI. MRI examination consists of T1 weighted (TR: 315&ndash;515 ms, TE 8.5&ndash;32.5 ms, field of view 20&ndash;25 cm) and T2 weighted (TR 3500&ndash;5500 ms, TE 100&ndash;130 ms, field of view 20&ndash;25 c
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Nosiba, Saeed Awad Ali, Ahmed Hassan Hussein, and alsied Hasan Amel. "The Function of Apparent Diffusion Coefficient and Diffusion-Weighted Imaging in Distinguishing between Different Types of Brain Tumors." International Journal of Current Science Research and Review 08, no. 04 (2025): 1821–32. https://doi.org/10.5281/zenodo.15259658.

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Abstract : <strong>Introduction:</strong>&nbsp;The second most common cause of mortality globally is tumors, and early detection is crucial for improving outcomes. Brain tumors, characterized by abnormal cell growth in the brain, can be either benign or malignant. Although conventional MRI techniques are routinely used for diagnosis, they often lack the sensitivity needed for tumor grading and characterization. By determining the apparent diffusion coefficient (ADC) value for each tumor and contrasting these results with the final histology result, this study seeks to evaluate the function of
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Olsen, Ø. E., and N. J. Sebire. "Apparent diffusion coefficient maps of pediatric mass lesions with free-breathing diffusion-weighted magnetic resonance: feasibility study." Acta Radiologica 47, no. 2 (2006): 198–204. http://dx.doi.org/10.1080/02841850500479651.

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Purpose: To assess the technical feasibility of apparent diffusion coefficient (ADC) mapping based on free-breathing diffusion-weighted magnetic resonance (DW-MR) outside the CNS in children. Material and Methods: Twelve children with mass lesions of varied histopathology were scanned with short- tau inversion recovery (STIR), contrast-enhanced T1-weighted (CE-T1W), and diffusion-weighted (b = 0, 500 and 1000 s/mm2) sequences. ADC maps were calculated. Lesion-to-background signal intensity ratios were measured and compared between STIR/CE-T1W/ADC overall (Friedman test) and between viable embr
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Ristic-Balos, Dragana, Svetlana Gavrilovic, Slobodan Lavrnic, et al. "Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions." Vojnosanitetski pregled 70, no. 7 (2013): 637–44. http://dx.doi.org/10.2298/vsp110223044r.

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Background/Aim. Advanced magnetic resonance techniques can provide insight in physiological changes within pathological canges and contribute to better distinquishing between different tumor types and their discrimination from non-neoplastic lesions. The aim of this study was to evaluate the role of proton magnetic resonance spectroscopy (1H-MRS) and apparent diffusion coefficients (ADC) in distinguishing intracranial glial tumors from tumor like nonneoplastic lesions, as well as for differentiating high- from low-grade gliomas. Methods. This retrospective study included 47 patients with solid
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Shahin, Esraa R. M., Hossam A. E. Zayton, Basma S. El-Deeb, and Hanan A. N. M. Saleh. "Diagnostic value of diffusion-weighted MRI in evaluation of urinary bladder lesions." Tanta Medical Journal 53, no. 3 (2025): 315–23. https://doi.org/10.4103/tmj.tmj_78_24.

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Background Diffusion-weighted MRI (DW-MRI) has been used vastly in the evaluation of pelvi-abdominal lesions through qualitative assessment depending on tissue cellularity and quantitative assessment to detect the diffusion degree through calculating apparent diffusion coefficient (ADC). Aim This research aimed to define the role of DW-MRI and apparent diffusion coefficient when added to T2-weighted imaging and contrast-enhanced MRI in evaluation of urinary bladder (UB) lesions. Patients and methods A total of 40 patients, with UB masses/thickening discovered by previous ultrasound or computed
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Dudhe, Sakshi, Gaurav Mishra, Pratapsingh Parihar, Dhananjay Shinde, and Anjali Kumari. "MRI based evaluation of carcinoma gallbladder using apparent diffusion coefficient (ADC) and diffusion weighted imaging (DWI)." F1000Research 13 (April 29, 2024): 414. http://dx.doi.org/10.12688/f1000research.143953.1.

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Background Carcinoma of the gallbladder is a malignant neoplasm, which is associated with a poor prognosis due to its often-asymptomatic nature and late-stage diagnosis. Non-invasive imaging techniques play a key role in the early detection and characterization of gallbladder carcinoma. This thesis presents a comprehensive analysis of the utility of Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) mapping in the magnetic resonance imaging (MRI) evaluation of carcinoma of the gallbladder. The primary objective of this research was to investigate the exact diagnostic acc
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Iqbal, Bushra, Nadia Gul, Khalid Mehmood, Sobia Jawwad, Kanza Afzal, and Muhammad Yousaf. "Diagnostic Accuracy of Apparent Diffusion Coefficient Value in Differentiating Benign and Malignant Brain Lesions Keeping Histopathology as Gold Standard." Life and Science 4, no. 2 (2023): 06. http://dx.doi.org/10.37185/lns.1.1.299.

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Objective: The purpose of this study was to assess the competence of preoperative Apparent Diffusion Coefficient (ADC) values in predicting brain tumors as benign or malignant, keeping histopathology as the gold standard.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Diagnostic Radiology, POF Hospital, Wah Cantt, Pakistan, from December 12th 2020 to June 9th 2021.Materials and Methods: The apparent diffusion coefficient (ADC) sequence is based on the diffusion properties of water molecules within tissues and correlates with tissu
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Na, Sa-Ra, Kwan-Woo Choi, No-Hyun Koo, Beong-Gyu Yoo, and Soon-Yong Son. "A Change of Apparent Diffusion Coefficient in Diffusion Weighted Imaging Applied with Rectangular FOV Technique." Journal of the Korean Society of Radiology 10, no. 7 (2016): 545–50. http://dx.doi.org/10.7742/jksr.2016.10.7.545.

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Ustabasioglu, Fethi Emre, Cesur Samanci, Deniz Alis, Nilay Sengul Samanci, Osman Kula, and Deniz Cebi Olgun. "Apparent Diffusion Coefficient Measurement in Mediastinal Lymphadenopathies: Differentiation between Benign and Malignant Lesions." Journal of Clinical Imaging Science 7 (March 6, 2017): 12. http://dx.doi.org/10.4103/jcis.jcis_84_16.

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Objectives:We aimed to prospectively assess the diagnostic value of apparent diffusion coefficient (ADC) measurement in the differentiation of benign and malignant mediastinal lymphadenopathies.Materials and Methods:The study included 63 consecutive patients (28 women, 35 men; mean age 59.3 years) with 125 mediastinal lymphadenopathies. Echoplanar diffusion-weighted magnetic resonance imaging of the mediastinum was performed with b-factors of 0 and 600 mm2/s before mediastinoscopy and mediastinotomy, and ADC values were measured. The ADC values were compared with the histological results, and
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Rulseh, Aaron Michael, and Josef Vymazal. "Whole brain apparent diffusion coefficient measurements correlate with survival in glioblastoma patients." Journal of Neuro-Oncology 146, no. 1 (2019): 157–62. http://dx.doi.org/10.1007/s11060-019-03357-y.

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Abstract Introduction Glioblastoma (GBM) is the most common malignant primary brain tumor, and methods to improve the early detection of disease progression and evaluate treatment response are highly desirable. We therefore explored changes in whole-brain apparent diffusion coefficient (ADC) values with respect to survival (progression-free [PFS], overall [OS]) in a cohort of GBM patients followed at regular intervals until disease progression. Methods A total of 43 subjects met inclusion criteria and were analyzed retrospectively. Histogram data were extracted from standardized whole-brain AD
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Colombo, Alberto, Giulia Saia, Alcide A. Azzena, et al. "Semi-Automated Segmentation of Bone Metastases from Whole-Body MRI: Reproducibility of Apparent Diffusion Coefficient Measurements." Diagnostics 11, no. 3 (2021): 499. http://dx.doi.org/10.3390/diagnostics11030499.

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Using semi-automated software simplifies quantitative analysis of the visible burden of disease on whole-body MRI diffusion-weighted images. To establish the intra- and inter-observer reproducibility of apparent diffusion coefficient (ADC) measures, we retrospectively analyzed data from 20 patients with bone metastases from breast (BCa; n = 10; aged 62.3 ± 14.8) or prostate cancer (PCa; n = 10; aged 67.4 ± 9.0) who had undergone examinations at two timepoints, before and after hormone-therapy. Four independent observers processed all images twice, first segmenting the entire skeleton on diffus
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Abd-Alhamid, Tarek, Ahmed G. Khafagy, Hesham Al Sersy, et al. "Certainty of pretreatment apparent diffusion coefficient in the characterization of thyroid gland pathologies." Egyptian Journal of Otolaryngology 33, no. 2 (2017): 495–501. http://dx.doi.org/10.4103/1012-5574.206019.

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Abstract Introduction One of the most recent techniques in imaging tumors is the diffusion-weighted MRI. It provides information regarding the metabolic, molecular, and pathophysiological aspects of tumors, especially thyroid gland cancer. Diffusion-weighted imaging (DWI) has also been proposed as a sensitive marker for monitoring treatment response in head and neck cancers. The biophysical mechanism of DWI is based on the translational motion of water molecules in tissues. The magnitude of this motion is characterized by its apparent diffusion coefficient (ADC) values. Objective The aim of th
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Xue, Jun Lai, Meng Chao Zhang, Mao Hua Zhang, Dong Tong, and Wu Qiang. "Study of Multi-b-Value Diffusion-Weighted Imaging at 3.0 T for Measuring Renal Function of Patients with Chronic Renal Failure." Advanced Materials Research 998-999 (July 2014): 320–24. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.320.

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To investigate the relationship between apparent diffusion coefficient (ADC) values measured by diffusion-weighted imaging (DWI) on a 3.0T MR unit and glomerular filtration rate (GFR) determined by renal imaging using Nuclear Medicine 99 Tcm-DTPA. 3.0T MRI DWI and 99 Tcm-DTPA renal imaging were simultaneously performed in 30 patients with chronic renal failure. The b values set for DWI imaging were 0, 200, 400, 600, 800 and 1000 s/mm2 and the ADC values of renal cortex were measured. 60 kidneys from the patients were classified into three groups according to the measurements of GFR: mildly imp
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Surov, Alexey, Lisa Paul, Hans Meyer, Stefan Schob, Cornelius Engelmann, and Andreas Wienke. "Apparent Diffusion Coefficient Is a Novel Imaging Biomarker of Myopathic Changes in Liver Cirrhosis." Journal of Clinical Medicine 7, no. 10 (2018): 359. http://dx.doi.org/10.3390/jcm7100359.

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Diffusion weighted imaging can provide information regarding tissue composition and can quantitatively characterize different pathological changes by means of apparent diffusion coefficient (ADC). The study comprised of 114 patients with liver cirrhosis—22 women and 92 men with a mean age of 56.5 ± 9.0 years. In all patients, the Model for End Stage-Liver Disease (MELD) score was calculated. Furthermore, 12 healthy persons (5 women, 7 men), mean age, 42.1 ± 16.2 years, were investigated as a control group. In all cases, magnetic resonance imaging of the liver/trunk was performed using differen
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Georgiev, Aleksandar, Lyubomir Chervenkov, Mladen Doykov, Katya Doykova, Petar Uchikov, and Silvia Tsvetkova. "Surveillance Value of Apparent Diffusion Coefficient Maps: Multiparametric MRI in Active Surveillance of Prostate Cancer." Cancers 15, no. 4 (2023): 1128. http://dx.doi.org/10.3390/cancers15041128.

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Background: This study aims to establish the value of apparent diffusion coefficient maps and other magnetic resonance sequences for active surveillance of prostate cancer. The study included 530 men with an average age of 66, who were under surveillance for prostate cancer. We have used multiparametric magnetic resonance imaging with subsequent transperineal biopsy (TPB) to verify the imaging findings. Results: We have observed a level of agreement of 67.30% between the apparent diffusion coefficient (ADC) maps, other magnetic resonance sequences, and the biopsy results. The sensitivity of th
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Marissa, Risa, Rachmi Fauziah Rahayu, Hari Wujoso, Subandi Subandi, Prasetyo Sarwono Putro, and Widiastuti Soewondo. "The diagnostic value of apparent diffusion coefficient to differentiate benign and malignant meningiomas." Universa Medicina 40, no. 2 (2021): 141–50. http://dx.doi.org/10.18051/univmed.2021.v40.141-150.

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BACKGROUNDMeningiomas are the most common primary extra-axial non-glial intracranial tumors. The severe grade of meningioma, according to WHO, has the highest recurrence rate accompanied by high morbidity and mortality rates. Therefore, it is imperative to perform pre-operative assessments so the clinician can give prompt treatment to gain a better prognosis. It is a novel alternative way of predicting meningioma’s malignancy by calculating the tumor’s apparent diffusion coefficient (ADC) value. The objective of the study was to determine the value of ADC for differentiating benign and maligna
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Ripp, V. O., P. E. Menshchikov, D. A. Kupriyanov, et al. "Possibilities of Using DWIBS for Clinical Tasks with the Measurement of the Apparent Diffusion Coefficient." Meditsinskaya Fizika 94, no. 2 (2022): 76–84. http://dx.doi.org/10.52775/1810-200x-2022-94-2-76-84.

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Additional suppression of the background signal in diffusion-weighted images (DWIBS) allows to get more contrast images to highlight areas with restricted diffusion, for example, in many malignant primary and metastatic tumors. Due to fundamental differences in DWIBS and DWI acquisition, the apparent diffusion coefficient (ADC) values may differ, which could negatively affect attempts to compare with the available literature data or with conventional DWI studies. Purpose. Evaluation of the correctness of the calculation of the ADC values based on DWIBS images, compared to regular DWI. Material
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Chen, Peiqian, Bing Dong, Chunye Zhang, Xiaofeng Tao, Pingzhong Wang, and Ling Zhu. "The histogram analysis of apparent diffusion coefficient in differential diagnosis of parotid tumor." Dentomaxillofacial Radiology 49, no. 5 (2020): 20190420. http://dx.doi.org/10.1259/dmfr.20190420.

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Objectives: Use apparent diffusion coefficient (ADC) histogram to investigate whether the parameters of ADC histogram can distinguish between benign and malignant tumors and further differentiate the tumor subgroups. Methods and materials: This study retrospectively enrolls 161 patients with parotid gland tumors. Histogram parameters including mean, inhomogeneity, skewness, kurtosis and 10th, 25th, 50th, 75th, 90th percentiles are derived from ADC mono-exponential model. Mann–Whitney U test is used to compare the differences between benign and malignant groups. Kruskal–Wallis test with post-ho
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Schlaug, G., B. Siewert, A. Benfield, R. R. Edelman, and S. Warach. "Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke." Neurology 49, no. 1 (1997): 113–19. http://dx.doi.org/10.1212/wnl.49.1.113.

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Walker-Samuel, Simon, Matthew Orton, Lesley D. McPhail, and Simon P. Robinson. "Robust estimation of the apparent diffusion coefficient (ADC) in heterogeneous solid tumors." Magnetic Resonance in Medicine 62, no. 2 (2009): 420–29. http://dx.doi.org/10.1002/mrm.22014.

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OĞUZMAN, Mehmet, Cüneyt ÇALIŞIR, and Ulukan İNAN. "DIFFUSION WEIGHTED IMAGING OF SOFT TISSUE MASSES: CAN APPARENT DIFFUSION COEFFICIENT MEASUREMENT DIFFERENTIATE BETWEEN MALIGNANT AND BENIGN LESIONS ?" Kocatepe Tıp Dergisi 24, no. 4 (2023): 481–87. http://dx.doi.org/10.18229/kocatepetip.1122866.

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AMAÇ: Yumuşak doku tümörlerinin değerlendirilmesinde di-füzyon ağırlıklı görüntüleme (DAG) yöntemi ile elde olunan gö-rünür difüzyon katsayısı (apparent diffusion coefficient, ADC) haritalamasının benign ve malign lezyonların ayrımında etkinli-ğini değerlendirmek ve bu lezyonların ayrımında kullanılabile-cek niceliksel ADC eşik değeri oluşturmak.GEREÇ VE YÖNTEM: Bu retrospektif çalışmaya yumuşak doku kitleleri nedeniyle DAG yapılan ve histopatolojik sonuçları mevcut olan toplam 34 hasta dahil edildi. Patolojik sonuçlarına göre hastalar benign ve malign lezyonlara sahip olarak katego-rize edild
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Endo, Toshiki, Shinsuke Suzuki, Akihiro Utsunomiya, Hiroshi Uenohara, and Teiji Tominaga. "Prediction of Neurological Recovery Using Apparent Diffusion Coefficient in Cases of Incomplete Spinal Cord Injury." Neurosurgery 68, no. 2 (2011): 329–36. http://dx.doi.org/10.1227/neu.0b013e3182031ce7.

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Abstract BACKGROUND: Magnetic resonance imaging is useful in evaluating acute spinal cord injury. Apparent diffusion coefficient (ADC) values obtained by diffusion-weighted imaging can differentiate cytotoxic edema from vasogenic edema through microscopic motion of water protons. OBJECTIVE: To determine whether ADC values in the cervical spinal cord match neurological grades and thus predict functional recovery in patients suffering from cervical spinal cord injury. METHODS: Diffusion-weighted images were obtained using 15 axial slices covering the cervical spinal cord from 16 consecutive pati
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