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1

Matthews, P. M., and D. L. Arnold. "Coenzyme Q." Neurology 43, no. 3, Part 1 (March 1, 1993): 628. http://dx.doi.org/10.1212/wnl.43.3_part_1.628.

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2

Bendahan, D., G. K. Ribbens, and P. J. Cozzone. "Coenzyme Q." Neurology 43, no. 3, Part 1 (March 1, 1993): 628. http://dx.doi.org/10.1212/wnl.43.3_part_1.628-a.

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3

Mortensen, Svend Aage. "Coenzyme Q 10." JACC: Heart Failure 3, no. 3 (March 2015): 270–71. http://dx.doi.org/10.1016/j.jchf.2014.12.006.

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4

Comhair, Suzy A. A., Deepa Grandon, Anam Khan, Renliang Zhang, Stanley L. Hazen, and Serpil C. Erzurum. "Coenzyme Q in Asthma." American Journal of Respiratory and Critical Care Medicine 191, no. 11 (June 2015): 1336–38. http://dx.doi.org/10.1164/rccm.201412-2259le.

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5

Morré, D. James, and Dorothy M. Morré. "Non-mitochondrial coenzyme Q." BioFactors 37, no. 5 (June 14, 2011): 355–60. http://dx.doi.org/10.1002/biof.156.

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6

Finsterer, Josef, and Sinda Zarrouk-Mahjoub. "Causes of low muscle coenzyme-Q levels beyond primary coenzyme-Q-deficiency." Molecular Genetics and Metabolism Reports 15 (June 2018): 96–97. http://dx.doi.org/10.1016/j.ymgmr.2018.03.006.

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7

Enriquez, José Antonio, and Giorgio Lenaz. "Coenzyme Q and the Respiratory Chain: Coenzyme Q Pool and Mitochondrial Supercomplexes." Molecular Syndromology 5, no. 3-4 (2014): 119–40. http://dx.doi.org/10.1159/000363364.

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8

Arroyo, Antonio, Carlos Santos-Ocaña, Macarena Ruiz-Ferrer, Sergio Padilla, Ángela Gavilán, Juan C. Rodríguez-Aguilera, and Plácido Navas. "Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane ofCaenorhabditis elegans." FEBS Letters 580, no. 7 (February 20, 2006): 1740–46. http://dx.doi.org/10.1016/j.febslet.2006.02.025.

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9

Beyer, Robert E. "An analysis of the role of coenzyme Q in free radical generation and as an antioxidant." Biochemistry and Cell Biology 70, no. 6 (June 1, 1992): 390–403. http://dx.doi.org/10.1139/o92-061.

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The vital role of coenzyme Q in mitochondrial electron transfer and its regulation, and in energy conservation, is well established. However, the role of coenzyme Q in free oxyradical formation and as an antioxidant remains controversial. Demonstration of the existence of the semiquinone form of coenzyme Q during electron transport, coupled with recent evidence that hydrogen peroxide (but not molecular oxygen) may act as an oxidant of the semiquinone, suggests that the highly reactive OH∙ radical may be formed from the semiquinone. On the other hand, data exist implicating the Fe–S species as the source of electron transfer chain, free radical production. Additional data exist suggesting instead that the unpaired electron of the coenzyme Q semiquinone most likely dismutates superoxide radicals. These concepts and those arising from observations at several levels of organization including subcellular systems, intact animals, and human subjects in the clinical setting, supporting the concept of reduced coenzyme Q as an antioxidant, will be presented. The results of recent studies on the interaction between the two-electron quinone reductase – DT diaphorase and coenzyme Q10 will be presented. The possibility that superoxide dismutase may interact with reduced coenzyme Q, in conjunction with DT diaphorase inhibiting its autoxidation, will be described. The regulation of cellular coenzyme Q concentrations during oxidative stress accompanying aerobic exercise, resulting in increased protection from free radical damage, will also be presented.Key words: coenzyme Q, ubiquinone, free radicals, lipid peroxidation, antioxidant, DT diaphorase, superoxide dismutase, review.
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10

Liancai, Zhu, Wang Bochu ., Tan Jun ., and Luo Min . "Coenzyme Q in Cancer Therapy." International Journal of Cancer Research 2, no. 3 (June 15, 2006): 290–98. http://dx.doi.org/10.3923/ijcr.2006.290.298.

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11

KAWASAKI, T. "Antioxidant Function of Coenzyme Q." Journal of Nutritional Science and Vitaminology 38, Special (1992): 552–55. http://dx.doi.org/10.3177/jnsv.38.special_552.

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12

Trevisson, Eva, Salvatore DiMauro, Placido Navas, and Leonardo Salviati. "Coenzyme Q deficiency in muscle." Current Opinion in Neurology 24, no. 5 (October 2011): 449–56. http://dx.doi.org/10.1097/wco.0b013e32834ab528.

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13

Garrido-Maraver, Juan. "Clinical applications of coenzyme Q₁₀." Frontiers in Bioscience 19, no. 4 (2014): 619. http://dx.doi.org/10.2741/4231.

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14

Bieri, John G. "UBIQUINONE (COENZYME Q) AND UBICHROMENOL." Nutrition Reviews 21, no. 5 (April 27, 2009): 129–31. http://dx.doi.org/10.1111/j.1753-4887.1963.tb04751.x.

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15

Crane, Frederick L. "The evolution of coenzyme Q." BioFactors 32, no. 1-4 (2008): 5–11. http://dx.doi.org/10.1002/biof.5520320102.

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16

Bentinger, Magnus, Michael Tekle, Kerstin Brismar, Tadeusz Chojnacki, Ewa Swiezewska, and Gustav Dallner. "Stimulation of coenzyme Q synthesis." BioFactors 32, no. 1-4 (2008): 99–111. http://dx.doi.org/10.1002/biof.5520320112.

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17

Quinzii, Catarina M., and Michio Hirano. "Coenzyme Q and mitochondrial disease." Developmental Disabilities Research Reviews 16, no. 2 (August 27, 2010): 183–88. http://dx.doi.org/10.1002/ddrr.108.

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18

Roels, Oswald A. "Present Knowledge of Coenzyme Q*." Nutrition Reviews 25, no. 4 (April 27, 2009): 97–100. http://dx.doi.org/10.1111/j.1753-4887.1967.tb05589.x.

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19

Bentinger, Magnus, Michael Tekle, and Gustav Dallner. "Coenzyme Q – Biosynthesis and functions." Biochemical and Biophysical Research Communications 396, no. 1 (May 2010): 74–79. http://dx.doi.org/10.1016/j.bbrc.2010.02.147.

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20

Appelkvist, E. L., F. Åberg, Z. Guan, I. Parmryd, and G. Dallner. "Regulation of Coenzyme Q biosynthesis." Molecular Aspects of Medicine 15 (January 1994): s37—s46. http://dx.doi.org/10.1016/0098-2997(94)90011-6.

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21

Dallner, Gustav. "Regulation of coenzyme Q biosynthesis." Chemistry and Physics of Lipids 164 (August 2011): S12. http://dx.doi.org/10.1016/j.chemphyslip.2011.05.048.

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22

Crane, F. L. "New functions for coenzyme Q." Protoplasma 213, no. 3-4 (September 2000): 127–33. http://dx.doi.org/10.1007/bf01282150.

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23

Galinier, A., A. Carrière, Y. Fernandez, A. M. Bessac, S. Caspar-Bauguil, B. Periquet, M. Comtat, J. P. Thouvenot, and L. Casteilla. "Biological validation of coenzyme Q redox state by HPLC-EC measurement: relationship between coenzyme Q redox state and coenzyme Q content in rat tissues." FEBS Letters 578, no. 1-2 (November 4, 2004): 53–57. http://dx.doi.org/10.1016/j.febslet.2004.10.067.

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24

James, Andrew M., Helena M. Cochemé, Masatoshi Murai, Hideto Miyoshi, and Michael P. Murphy. "Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain." FEBS Journal 277, no. 9 (March 22, 2010): 2067–82. http://dx.doi.org/10.1111/j.1742-4658.2010.07622.x.

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25

Bentinger, Magnus, Kerstin Brismar, and Gustav Dallner. "The antioxidant role of coenzyme Q." Mitochondrion 7 (June 2007): S41—S50. http://dx.doi.org/10.1016/j.mito.2007.02.006.

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26

Sohal, Rajindar S., and Michael J. Forster. "Coenzyme Q, oxidative stress and aging." Mitochondrion 7 (June 2007): S103—S111. http://dx.doi.org/10.1016/j.mito.2007.03.006.

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27

Crane, Frederick L., and Plácido Navas. "The diversity of coenzyme Q function." Molecular Aspects of Medicine 18 (January 1997): 1–6. http://dx.doi.org/10.1016/s0098-2997(97)00016-2.

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28

Stefely, Jonathan A., and David J. Pagliarini. "Biochemistry of Mitochondrial Coenzyme Q Biosynthesis." Trends in Biochemical Sciences 42, no. 10 (October 2017): 824–43. http://dx.doi.org/10.1016/j.tibs.2017.06.008.

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29

Turunen, M., E. Swiezewska, T. Chojnacki, P. Sindelar, and G. Dallner. "Regulatory Aspects of Coenzyme Q Metabolism." Free Radical Research 36, no. 4 (January 2002): 437–43. http://dx.doi.org/10.1080/10715760290021298.

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30

Bour, Sandy, Maria-Carmen Carmona, Anne Galinier, Sylvie Caspar-Bauguil, Luc Van Gaal, Bart Staels, Luc Pénicaud, and Louis Casteilla. "Coenzyme Q as an Antiadipogenic Factor." Antioxidants & Redox Signaling 14, no. 3 (February 2011): 403–13. http://dx.doi.org/10.1089/ars.2010.3350.

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31

Garrido-Maraver, Juan, Mario D. Cordero, Manuel Oropesa-Ávila, Alejandro Fernández Vega, Mario de la Mata, Ana Delgado Pavón, Manuel de Miguel, et al. "Coenzyme Q10 Therapy." Molecular Syndromology 5, no. 3-4 (2014): 187–97. http://dx.doi.org/10.1159/000360101.

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32

Kawamukai, Makoto. "Biosynthesis of coenzyme Q in eukaryotes." Bioscience, Biotechnology, and Biochemistry 80, no. 1 (July 17, 2015): 23–33. http://dx.doi.org/10.1080/09168451.2015.1065172.

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33

Lass, Achim, Linda Kwong, and Rajindar S. Sohal. "Mitochondrial coenzyme Q content and aging." BioFactors 9, no. 2-4 (1999): 199–205. http://dx.doi.org/10.1002/biof.5520090215.

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34

Lipshutz, Bruce H., Gerd Bulow, Fernando Fernandez-Lazaro, Sung-Kyu Kim, Richard Lowe, Paul Mollard, and Kirk L. Stevens. "A Convergent Approach to Coenzyme Q." Journal of the American Chemical Society 121, no. 50 (December 1999): 11664–73. http://dx.doi.org/10.1021/ja992164p.

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35

Navas, Plácido. "The Way to Determine Coenzyme Q." Journal of the American College of Cardiology 62, no. 3 (July 2013): 257. http://dx.doi.org/10.1016/j.jacc.2013.02.083.

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36

Landi, Laura, Luciana Cabrini, Diana Fioremtini, Anna Maria Sechi, Giorgio Sartor, Petronio Pasquali, and Lanfranco Masotti. "Coenzyme Q-3 as an antioxidant." Cell Biophysics 16, no. 1-2 (January 1990): 1–12. http://dx.doi.org/10.1007/bf02989689.

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37

Turunen, Mikael, Jerker Olsson, and Gustav Dallner. "Metabolism and function of coenzyme Q." Biochimica et Biophysica Acta (BBA) - Biomembranes 1660, no. 1-2 (January 2004): 171–99. http://dx.doi.org/10.1016/j.bbamem.2003.11.012.

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38

Clarke, Catherine F. "New advances in coenzyme Q biosynthesis." Protoplasma 213, no. 3-4 (September 2000): 134–47. http://dx.doi.org/10.1007/bf01282151.

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39

Nohl, Hans, Andrey V. Kozlov, Katrin Staniek, and Lars Gille. "The Multiple Functions of Coenzyme Q." Bioorganic Chemistry 29, no. 1 (February 2001): 1–13. http://dx.doi.org/10.1006/bioo.2000.1193.

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40

Scialo, Filippo, and Alberto Sanz. "Coenzyme Q redox signalling and longevity." Free Radical Biology and Medicine 164 (February 2021): 187–205. http://dx.doi.org/10.1016/j.freeradbiomed.2021.01.018.

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41

Kopřiva, Vladimír, Petr Dvořák, Jana Pokorná, and Michal Žďárský. "Coenzyme Q 10 – its biochemical and related aspects." Acta Veterinaria Brno 84, no. 1 (2015): 43–46. http://dx.doi.org/10.2754/avb201585010043.

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This review analyses the findings of biochemical and related pharmacotherapeutical aspects of coenzyme Q10. Its important role in the respiratory chain is presented. Furthermore, the article presents administration of coenzyme Q10 as a supplement within preventative measures in medicine, its pharmacotherapeutical aspects and effects in a number of diseases of various aetiologies. Concurrently, it presents the issue of mutual interactions of coenzyme Q10 and its efficacy in combining supplementation with conservative therapy of selected aetiologies.
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42

Takayasu, Shoji, and Sanae Katori. "Meniere's Disease and Coenzyme Q10 (1)." Practica oto-rhino-laryngologica. Suppl. 1986, Supplement8 (1986): 249–55. http://dx.doi.org/10.5631/jibirinsuppl1986.1986.supplement8_249.

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43

Boreková, M., J. Hojerová, V. Koprda, and K. Bauerová. "Nourishing and health benefits of coenzyme Q10." Czech Journal of Food Sciences 26, No. 4 (August 22, 2008): 229–41. http://dx.doi.org/10.17221/1122-cjfs.

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Coenzyme Q<sub>10</sub> is an important mitochondrial redox component and endogenously produced lipid-soluble antioxidant of the human organism. It plays a crucial role in the generation of cellular energy, enhances the immune system, and acts as a free radical scavenger. Ageing, poor eating habits, stress, and infection – they all affect the organism’s ability to provide adequate amounts of CoQ<sub>10</sub>. After the age of about 35, the organism begins to lose the ability to synthesise CoQ<sub>10</sub> from food and its deficiency develops. Many researches suggest that using CoQ<sub>10</sub> supplements alone or in combination with other nutritional supplements may help maintain health of elderly people or treat some of the health problems or diseases. Due to these functions, CoQ<sub>10</sub> finds its application in different commercial branches such as food, cosmetic, or pharmaceutical industries. This review article gives a survey of the history, chemical and physical properties, biochemistry and antioxidant activity of CoQ<sub>10</sub> in the human organism. It discusses levels of CoQ<sub>10</sub> in the organisms of healthy people, stressed people, and patients with various diseases. This paper shows the distribution and contents of two ubiquinones in foods, especially in several kinds of grapes, the benefits of CoQ<sub>10</sub> as nutritional and topical supplements and its therapeutic applications in various diseases.
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44

Ahmad, SyedS. "Coenzyme Q and its role in glaucoma." Saudi Journal of Ophthalmology 34, no. 1 (2020): 45. http://dx.doi.org/10.4103/1319-4534.301299.

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45

Tran, UyenPhuong C., and Catherine F. Clarke. "Endogenous synthesis of coenzyme Q in eukaryotes." Mitochondrion 7 (June 2007): S62—S71. http://dx.doi.org/10.1016/j.mito.2007.03.007.

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46

Obol'nikova, E. A., and A. I. Kozhukhova. "Biological activity of coenzyme Q analogs (review)." Pharmaceutical Chemistry Journal 27, no. 12 (December 1993): 826–33. http://dx.doi.org/10.1007/bf00780572.

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47

Sharp, Jacqueline, Samar Farha, Margaret M. Park, Suzy A. Comhair, Erika L. Lundgrin, W. H. Wilson Tang, Robert D. Bongard, Marilyn P. Merker, and Serpil C. Erzurum. "Coenzyme Q supplementation in pulmonary arterial hypertension." Redox Biology 2 (2014): 884–91. http://dx.doi.org/10.1016/j.redox.2014.06.010.

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48

Bogeski, Ivan, Rubin Gulaboski, Reinhard Kappl, Valentin Mirceski, Marina Stefova, Jasmina Petreska, and Markus Hoth. "Calcium Binding and Transport by Coenzyme Q." Journal of the American Chemical Society 133, no. 24 (June 22, 2011): 9293–303. http://dx.doi.org/10.1021/ja110190t.

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49

Willis, R. A., K. Folkers, J. L. Tucker, C. Q. Ye, L. J. Xia, and H. Tamagawa. "Lovastatin decreases coenzyme Q levels in rats." Proceedings of the National Academy of Sciences 87, no. 22 (November 1, 1990): 8928–30. http://dx.doi.org/10.1073/pnas.87.22.8928.

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50

Folkers, K., P. Langsjoen, R. Willis, P. Richardson, L. J. Xia, C. Q. Ye, and H. Tamagawa. "Lovastatin decreases coenzyme Q levels in humans." Proceedings of the National Academy of Sciences 87, no. 22 (November 1, 1990): 8931–34. http://dx.doi.org/10.1073/pnas.87.22.8931.

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