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Journal articles on the topic 'Cognac products'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Bouët, Antoine, Charlotte Emlinger, and Viola Lamani. "What Determines Exports of Luxury Products? The Case of Cognac." Journal of Wine Economics 12, no. 1 (2017): 37–58. http://dx.doi.org/10.1017/jwe.2017.2.

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AbstractThis paper analyzes the determinants of Cognac brandy exports using a unique database on Cognac shipments to more than 140 destinations between 1996 and 2013. We use this database to construct descriptive statistics concerning the evolution of Cognac exports during this period. We also construct a database of protectionist policies that affect worldwide Cognac exports. We analyze the determinants of Cognac exports and base our empirical strategy on Heckman's (1979) procedure. We estimate successively the impact of geographical, demand and policy factors on the extensive margin of trade

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Eliseev, M. N., V. P. Osipova, L. K. Emelyanova, D. G. Lakutin, and O. M. Alekseeva. "The quality indicators of french cognac." Proceedings of the Voronezh State University of Engineering Technologies 81, no. 1 (2019): 66–71. http://dx.doi.org/10.20914/2310-1202-2019-1-66-71.

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Alcohol products are very popular in the consumer market, although it is not a highly needed and essential product. Cognac is one of the exquisite aristocratic and sophisticated beverage, its production consist of complex and lengthy technological process, on which an unique, full bouquet and aroma directly depend. This determines the importance of such aspects as obtaining a high quality and environmentally safe products that have some positive effect on the human body. Moreover, for cognac, the most important is the quality of the original wine materials and new production technologies, whic

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3

Aliskerov, Abduragim R., and Olga V. Pavlenko. "Actual Issues of Identification and Examination of Cognac Distillate for Customs Purposes." Вестник Российской таможенной академии, no. 4 (2022): 112–24. http://dx.doi.org/10.54048/20727240_2022_04_112.

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The article shows the existence of the problem of identifying cognac distillate in the production of customs expertise; the composition of stable carbon isotopes 13C/12C in ethanol was established on genuine samples of cognac products in the south of Russia; the insufficiency of determining the indicators of GOST 31728-2014 and the ratio of stable carbon isotopes 13C/12C in ethanol to detect falsification of cognac products was proved. The authors of the article focused on the study of cognac distillates using an integrated approach, including the establishment of organoleptic and physico-chem

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КАМАЛОВА, Т. А., and М. М. АЛИЕВА. "MANAGING THE PROMOTION OF COGNAC PRODUCTS." Экономика и предпринимательство, no. 6(155) (August 2, 2023): 714–17. http://dx.doi.org/10.34925/eip.2023.155.6.127.

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В статье проведен анализ продвижения продукции Кизлярского коньячного завода. Выявлено, что на заводе проводятся лишь отдельные маркетинговые мероприятия, но нет комплексного маркетингового подхода. Показано, что продвижение товаров в интернете с использованием скрытого маркетинга, крауд-маркетинга в сообществах и социальных сетях позволяют разработать для клиента эффективную стратегию продвижения коньячной продукции с применением методов, находящихся в рамках закона «О рекламе». Обоснована необходимость внедрения в систему управления предприятием маркетинговых подходов. The article analyzes t

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Panahov, Tariyel. "On the study of the scientific basis for the use of products of processing of oak wood in the wine industry of the Republic of Azerbaijan." Bank and Policy 2, no. 2 (2022): 146–56. https://doi.org/10.5281/zenodo.6479139.

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In all countries where viticulture and winemaking are developed, cognac production occupies a special place in the alcohol industry, with specific features. The individual characteristics of this drink are formed due to many factors based on soil and climatic conditions, applied agrotechnical measures and features of production technology. Currently, the world is modernizing the material and technical base of cognac production, enriching the raw material base, improving the quality and rational use of auxiliary materials, selecting and identifying grape varieties, developing new technolog

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Михаил Николаевич, Елисеев,, Косарева, Ольга Александровна, and Грибкова, Ирина Николаевна. "New approaches principles to assessing the cognac products quality." Food processing industry, no. 1 (January 10, 2023): 64–67. http://dx.doi.org/10.52653/ppi.2023.1.1.014.

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Статья посвящена проблеме оценки качества коньячной продукции, которая обусловлена влиянием совокупности факторов, таких как сырье, микроорганизмы, длительность, условия выдержки и т. д. Показано, что сенсорные свойства готового коньяка формируются за счет фурановых, фенольных и прочих органических соединений, появляющихся и преобразующихся в ходе технологического процесса. Поставленная цель работы - установление неявных связей между органическими соединениями, извлекаемыми и образующимися при выдержке в контакте с древесиной, коньячных дистиллятов с помощью методов математического моделирован

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Mitrofanova, E. A., T. I. Guguchkina, K. V. Reznichenko, O. P. Antonenko, and O. N. Sheludko. "ADDITIONAL PHYSICAL AND CHEMICAL PARAMETERS OF COGNAC PRODUCTS AUTHENTICITY." Scientific Works of North Caucasian Federal Scientific Center of Horticulture, Viticulture, Wine-making 23 (June 2019): 243–46. http://dx.doi.org/10.30679/2587-9847-2019-23-243-246.

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ЧУРСИНА, О. А., В. А. ЗАГОРУЙКО, Л. А. ЛЕГАШЕВА, et al. "ASSESSMENT OF THE COLOR OF AGED BRANDY DISTILLATES BASED ON THEIR OPTICAL CHARACTERISTICS AND COMPOSITION OF THE PHENOLIC COMPLEX." Известия вузов. Пищевая технология, no. 2-3(396) (June 11, 2024): 114–19. http://dx.doi.org/10.26297/0579-3009.2024.2-3.19.

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Цвет является важной характеристикой при оценке качества и идентификации винодельческой продук- ции. У коньяка и коньячных дистиллятов он характеризуется от светло-золотистого до темно-янтарного или тем- но-коричневого и обусловлен компонентами фенольного состава, экстрагируемыми из древесины дуба. Однако определение цвета винопродукции визуально с помощью описательных характеристик не позволяет однозначно интерпретировать результат оценки из-за субъективности метода и многочисленности понятий и терминов. В свя- зи с этим для количественного выражения цвета наиболее актуальными являются спектр

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Devi, Maibam Sunita, Sanasam Sanjeev, Khushboo Maurya, Vikas Kumar Roy, and Guruswami Gurusubramanian. "Implications of Use of Tobacco Smoke Infused Water." Science & Technology Journal 5, no. 1 (2017): 22–31. http://dx.doi.org/10.22232/stj.2017.05.01.03.

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Smokeless Tobacco Products have been collectivelydesignated as Group 1 carcinogens i.e. carcinogenicto humans.It is estimated that the use of tobacco kills about three million people globally every year. A number of smoking and smokeless tobacco products are in use all over the world. Unlike other smokeless tobacco products, a unique water (liquid preparation) containing the extracts of tobacco smoke is used in Mizoram and is locally known as tuibur (tobacco smoke infused water).This product is made locally by passing smoke, generated by burning tobacco, through water till the preparation turn

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Leshchev, S. M., M. F. Zayats, R. A. Yurchenko, and V. A. Vinarskii. "Development and use of extraction sample preparation in the chromatographic-mass spectrometric studies of cognac products." Journal of Analytical Chemistry 63, no. 7 (2008): 629–36. http://dx.doi.org/10.1134/s1061934808070058.

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11

Sasges, Gerard. "Drunken poets and new women: Consuming tradition and modernity in colonial Vietnam." Journal of Southeast Asian Studies 48, no. 1 (2017): 6–30. http://dx.doi.org/10.1017/s002246341600045x.

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This article uses the lens of alcohol as a means of exploring the experiences and anxieties of Vietnamese ‘colonial modernity’ and the way it was mutually constituted with ‘colonial tradition’. The production, consumption, and meaning of alcohol in Vietnam were all profoundly altered as the state's contested attempts to control the market for rice liquor interacted with the growing availability of imports like wine, champagne, and cognac. While these new products would become ideal symbols of modernity and markers of distinction, at the same time reinvented traditions surrounding what the Fren

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12

Likhovskoi, Vladimir Vladimirovich, and Igor' Pavlovich Lutkov. "MODERN TASKS OF SCIENTIFIC RESEARCH IN THE FIELD OF WINEMAKING." Fruit growing and viticulture of South Russia 1, no. 85 (2024): 113–30. http://dx.doi.org/10.30679/2219-5335-2024-1-85-113-130.

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The article presents the results of research activities for 2023 of the Federal State Budget Scientific Institution All-Russian National Research Institute of Viticulture and Winemaking Magarach of the RAS in the field of winemaking, carried out in accordance with the Program of Fundamental Scientific Research in the Russian Federation for the long term (2021-2030). The methodology of wine quality management with ecostatus has been created, aimed at revealing the individual characteristics of wines caused by natural factors and reducing the risks of negative effects on humans. Promising yeast

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Bujancă, Gabriel, Călin Jianu, Nicoleta Gabriela Hădărugă, Ioan David, Ducu Sandu Ștef, and Corina Iuliana Megyesi. "Characterization of different assortments of distilled alcoholic beverages from Banat region (Romania)." Journal of Agroalimentary Processes and Technologies 2024 (30), no. 4 (2025): 491–96. https://doi.org/10.59463/japt.2024.2.52.

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The aim of this work was to give the analyzed products (different distilled alcoholic beverages from Banat region, Romania) a better appreciation because of the great organoleptic properties they possesses. The finished product specific to Banat, is palinca and is an alcoholic drink with at least 50% vol (alcohol levels), obtained through the specific process of fruit fermentation and double distillation, without the addition of sugar, other sweeteners or synthetic flavors, with natural coloring (from the barrel). These drinks are highly competitive worldwide with other similar products such a

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14

Kriepakova, M. Yu. "Foreign experience of legal regulation for separate offenses administrative liability and the possibility of its application in Ukraine." Law and Safety 82, no. 3 (2021): 166–72. http://dx.doi.org/10.32631/pb.2021.3.19.

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The scientific novelty of the study is that the research is one of the first works that analyzes foreign experience in legal liability for the involvement of a minor in the use of tobacco products, e-cigarettes, liquids used in e-cigarettes, devices for the consumption of tobacco products without their combustion, and uses the developed results to further improve the national legislation governing administrative liability in Ukraine. In accordance with the purpose and objectives of the study, the article uses a set of general theoretical and special scientific methods and techniques of scienti

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15

Gamse, Thomas. "Industrial applications and current trends in supercritical fluid technologies." Chemical Industry 59, no. 9-10 (2005): 207–12. http://dx.doi.org/10.2298/hemind0510207g.

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Supercritical fluids have a great potential for wide fields of processes Although CO2 is still one of the most used supercritical gases, for special purposes propane or even fluorinated-chlorinated fluids have also been tested. The specific characteristics of supercritical fluids behaviour were analyzed such as for example the solubilities of different components and the phase equilibria between the solute and solvent. The application at industrial scale (decaffeinating of tea and coffee, hop extraction or removal of pesticides from rice), activity in supercritical extraction producing total e

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Моисеев, И. В., В. В. Лезный, Д. А. Карманов, Д. В. Бондаренко, and Г. П. Синчин. "Enzymatic Changes in the Chemical Composition of Cigar Tobacco Raw Materials in an Alcohol-containing Medium of an Oak Barrel from Under Cognac Distillate." Beer and beverages, no. 2 (June 19, 2024): 27–30. http://dx.doi.org/10.52653/pin.2024.02.08.

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Исследовано влияние спиртосодержащей среды на процесс ферментации сигарного табачного сырья в дубовой бочке из-под коньячного дистиллята. Проведена сравнительная оценка двух способов ферментации на примере кубинского сигарного табака сорта НР. Для этого были осуществлены химический анализ и органолептическая оценка неферментированного табака и образцов аналогичного табака, прошедших естественную и «алкогольную» ферментацию в течение 6 мес. Химический анализ образцов по основным показателям проводили с использованием методов высокоэффективной жидкостной хроматографии, титрометрии и потенциометр

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Krstic, Jelena, Milica Kostic-Stankovic, and Sonja Veljovic. "Traditional and innovative aging technologies of distilled beverages: The influence on the quality and consumer preferences of aged spirit drinks." Journal of Agricultural Sciences, Belgrade 66, no. 3 (2021): 209–30. http://dx.doi.org/10.2298/jas2103209k.

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Aging is one of the most important processes in the production of high-quality spirits, including whisky, brandy and cognac. The contact between wood and distillates is a crucial step for the migration of chemical compounds, which evoke the novel sensory properties of the final products. Novel taste is pleasurable for a vast group of consumers and depends on cultural preferences. In order to demystify the main chemical compounds for aroma contribution, connecting them with a sensory profile of aged spirits is a crucial step in hastening the very timeless process without decreasing the quality.

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Orlova, Ariza G., Zlata A. Ivanova, and Aishat M. Abdulayeva. "THE VITICULTURAL AND WINEMAKING SUBCOMPLEX OF THE AGRO-INDUSTRIAL COMPLEX REPUBLIC OF DAGESTAN." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 11/4, no. 152 (2024): 103–8. https://doi.org/10.36871/ek.up.p.r.2024.11.04.013.

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The article presents the scientific strategy of the viticulture and winemaking subcomplex of the agro-industrial complex, and carries out a theoretical analysis of ensuring an increase in the growth rate of viticulture and winemaking in the Republic of Dagestan. The importance of developing the industry of viticulture, winemaking, and cognac production has been updated and the main trends have been established; organizational issues of the winemaking subcomplex, problems and ways to solve them have been considered. The reasons were identified, caused by economic instability and the quality of

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Chyshko, K. O. "Theoretical and legal perspective on the content of the objectivity of Article 178 of the Ukrainian Code of Administrative Offences: thesis, antithesis, arguments, presentation." Bulletin of Kharkiv National University of Internal Affairs 101, no. 2 (P. 1) (2023): 124–34. http://dx.doi.org/10.32631/v.2023.2.12.

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The article is structured according to the elements of the logical operation of “proof”, which includes the following elements. Thesis: it is impossible to bring a person to administrative liability for violation of Article 178 of the Ukrainian Code of Administrative Offences for drinking beer, alcoholic or soft drinks in public places, if the person drinks these beverages, for example, in the apartment building entrance. Antithesis: administrative liability under Art. 178 of the Ukrainian Code of Administrative Offences is incurred for drinking beer, alcoholic or soft drinks in an

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Dolgosheva, E. V., T. N. Romanova, R. Kh Baimishev, and L. A. Korosteleva. "The utilization of strong alcoholic beverages while processing semi-smoked sausage." IOP Conference Series: Earth and Environmental Science 954, no. 1 (2022): 012026. http://dx.doi.org/10.1088/1755-1315/954/1/012026.

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Abstract The use of strong alcohol in the processing of semi-smoked sausages is proposed in order to impart aroma and taste to ready-made sausages, as well as to expand the assortment list of manufactured products. In the course of the study, 5 variants of semi-smoked sausages were processed under the State Standard 34162-2017 “Processing semi-smoked sausages. General processing terms”. The formulations of the prototypes include balsam, liqueur, cognac and rum in the amount of 4% by bulk of unsalted raw materials. Alcohol has denaturing properties with respect to protein, accompanying meat sof

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COLIBABA, Lucia Cintia, Stefan TUDOSE-SANDU-VILLE, Camelia LUCHIAN, Andreea POPIRDA, Marius NICULAUA, and Valeriu V. COTEA. "Studies Regarding the Main Compositional Parameters and Some Volatile Compounds in Spirits from Iaşi Vineyard." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture 74, no. 2 (2017): 137. http://dx.doi.org/10.15835/buasvmcn-hort:0013.

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The distillates obtained from wine, both raw and aged, are highly appreciated alcoholic beverages due to the refinement and fineness that characterizes them. Romania’s viticultural conditions are very favourable for these products - which in the last centuries have made regions such as Cognac and Armagnac in France famous. In Romania the aged distillate of wine is called “vinars” and in the Republic of Moldova it is named “divin”. This study analyses how the main compositional parameters and volatile compounds are influenced by the raw material wine, distillation technology, distillation steps

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Xintaoa, W., E. V. Zhiryaeva, and Zh Leting. "Benefits and Vulnerabilities of the Free Trade Agreement for the EAEU Countries and China." EURASIAN INTEGRATION: economics, law, politics 18, no. 3 (2024): 62–74. http://dx.doi.org/10.22394/2073-2929-2024-03-62-74.

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Aim. Objective is to formulate the position of the EAEU in the negotiations on the free trade area with China.Tasks. We determine the potential results of the creation of the China-EAEU free trade area for each country.Methods. The indices of complementarity and trade intensity were calculated, and the benefits to society from the abolition of customs tariffs were calculated using a partial equilibrium trade-policy simulation.Results. The study of supply and demand for excavators showed that the total benefit of consumers (the construction industry) from the abolition of customs duties only sl

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23

Vasylyk, Aleksandr, та Anatoly Yalanetskiy. "Оптимизация технологии получения молодых коньячных дистиллятов с использованием математического моделирования". Magarach. Vinogradstvo i Vinodelie, № 2(108) part: 21 (19 червня 2019): 162–67. http://dx.doi.org/10.35547/im.2019.21.2.017.

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Приведены основные схемы получения молодых коньячных дистиллятов на аппаратах периодического действия двойной сгонки (шарантского типа), традиционно применяемые в отечественном коньячном производстве и у классических французских производителей. При помощи математического моделирования проведен анализ и определен выход коньячного дистиллята с заданными кондициями и удельные энергетические затраты при одинаковых начальных условиях, но при различных вариантах перегонки. Произведен расчет кондиций основных получаемых продуктов и промежуточных фракций за один цикл дистилляции, а также за длительную

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Couch, A. T., and J. P. Conte. "Field Verification of Linear and Nonlinear Hybrid Wave Models for Offshore Tower Response Prediction." Journal of Offshore Mechanics and Arctic Engineering 119, no. 3 (1997): 158–65. http://dx.doi.org/10.1115/1.2829063.

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Accuracy of the prediction of the dynamic response of deepwater fixed offshore platforms to irregular sea waves depends very much on the theory used to determine wave kinematics. A common industry practice consists of using linear wave theory, which assumes infinitesimal wave steepness, in conjunction with empirical wave stretching techniques to provide a more realistic representation of near-surface water kinematics. The current velocity field is then added to the wave-induced fluid velocity field and the wave-and-current forces acting on the structure are computed via Morison’s equation. The

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Тихонова, О. Ю., Т. В. Котова, Н. В. Дмитриева, and С. Р. Царегородцева. "Gift packaging of alcoholic beverages: classification, trends in the formation of assortment and consumer preferences." Food processing industry, no. 10 (September 28, 2024): 40–45. http://dx.doi.org/10.52653/ppi.2024.10.10.007.

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Актуальность исследования подарочной упаковки (ПУ), как имиджевой составляющей товара, не вызывает сомнения и подтверждается растущим объемом рынка в России. Так, в 2023 г. российский рынок упаковки достиг 1,47 трлн руб. При этом рост отмечается как в денежном, так и в натуральном выражении, он составил 5 % к предыдущему году. Такие достаточно известные крупные компании, как Viewpoint, Depot, Эль Пако, Mildberry, полностью перешли на производство фирменных упаковок, уделяя большое внимание разработке самой упаковки, дизайну, стараясь придать брендовой продукции уникальный внешний вид. Цель – п

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Андриевская, Дарья Владиславовна, and Екатерина Владимировна Ульянова. "The Influence of the Mineral Composition of Alcoholic Beverages of Grape Origin on their Bottling Resistance." Beer and beverages, no. 4 (December 12, 2021): 11–13. http://dx.doi.org/10.52653/pin.2021.4.4.003.

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В настоящее время известны основные причины формирования различных видов помутнений в спиртных напитках виноградного происхождения. В значительной степени изучены компоненты образующихся при этом осадков. Вместе с тем одна из часто возникающих проблем современного производства заключается в потере стабильности продукции при транспортировании и хранении, что влечет дополнительные расходы предприятий по возврату и технологическим обработкам забракованной продукции. Целью настоящей работы стало сравнительное исследование минерального состава обработанных коньяков и их стабильности к различным вид

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Grünthal, Riho, and Johanna Nichols. "Transitivizing-detransitivizing typology and language family history." Lingua Posnaniensis 58, no. 2 (2016): 11–31. http://dx.doi.org/10.1515/linpo-2016-0008.

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AbstractThe transitivizing/detransitivizing typology of Nichols et al. 2004 also proves useful to historical linguistics. We focus on language families of northern Eurasia, chiefly the three oldest families (Indo-European, Uralic, Nakh-Daghestanian), some of their daughter branches aged about 2000-3000 years, and one younger family for which we have data on enough daughters to support a family phylogeny (Tungusic). We use the 18-pair wordlist of Nichols et al. 2004, which typologizes each pair of verbs depending on which of the two is derived. We make some improvements in the coding of grammat

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Luo, Jie, and Jufeng Ye. "Research on Object Defect Detection of Automated Pipeline Based on Cognex Camera." Frontiers in Computing and Intelligent Systems 10, no. 3 (2024): 115–17. https://doi.org/10.54097/fvp9q425.

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With the continuous improvement of people's living standards, higher requirements have been put forward for the efficiency of the manufacturing industry, so the application of automated pipeline in enterprises is becoming increasingly widespread. Due to various factors such as environment, labor, and technology that affect the manufacturing process of goods, some products have defects. It is necessary to screen out defective products in automated pipeline. This paper investigates the application of Cognex cameras in object defect detection on automated pipeline. The camera obtains material ima

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Sahakyan, A. V., M. K. Alenichev, and A. D. Levin. "Characterization of cognacs and grape brandies by fluorescence spectra processed using machine learning methods." Industrial laboratory. Diagnostics of materials 89, no. 10 (2023): 25–33. http://dx.doi.org/10.26896/1028-6861-2023-89-10-25-33.

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A method for express characterization of cognacs and grape brandies is proposed in the case study of their classification by geographical origin. The method is based on the use of informative fragments of fluorescence spectra of samples of different geographic origin and their subsequent processing using machine learning algorithms. Three types of fluorescence spectra were selected, i.e., spectra of synchronous scanning at a wavelength difference of 50 nm, and emission spectra at an excitation wavelength of 250 and 280 nm. These spectra were measured for 43 samples of cognacs and grape brandie

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Castañeda, Miguel, Josefina Guzmán, Soledad Moreno та Guadalupe Espín. "The GacS Sensor Kinase Regulates Alginate and Poly-β-Hydroxybutyrate Production in Azotobacter vinelandii". Journal of Bacteriology 182, № 9 (2000): 2624–28. http://dx.doi.org/10.1128/jb.182.9.2624-2628.2000.

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ABSTRACT Azotobacter vinelandii produces two polymers: the extracellular polysaccharide alginate and the intracellular polyester poly-β-hydroxybutyrate (PHB). A cosmid clone (pSMU588) from anA. vinelandii gene library diminished alginate production by A. vinelandii mucoid strain ATCC 9046. The nucleotide sequence and predicted amino acid sequence of the locus responsible for the mucoidy suppression revealed 65% identity toPseudomonas GacS, a transmembrane sensor kinase of the two-component regulators, whose cognate response regulator, GacA, is a global activator regulating several products and

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Nezalzova, Elena. "High-Performance Liquid Chromatography for Determination of Aromatic Aldehydes in Wine Distillates." Chemistry Journal of Moldova 6, no. 1 (2011): 81–85. http://dx.doi.org/10.19261/cjm.2011.06(1).06.

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Quality control of alcoholic beverages, coming into the market, is a defining element in preventing the production and supplying of defective products. One of the main criteria for quality control of wine distillates is to estimate their age, and more precisely the period of maturation as the dominant factor in determining the quality of cognacs and, consequently, their market price. On the opinion of majority scientists, one of the main factors, which determines the age of wine distillates, is the content of aromatic aldehydes, mostly vanillin, and their ratio.

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LEVY, MIKE. "CALL by design: discourse, products and processes." ReCALL 14, no. 1 (2002): 58–84. http://dx.doi.org/10.1017/s0958344002000617.

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‘Design’ is a term that is familiar to many language teachers and CALL practitioners. It is used regularly in relation to curriculum, syllabus, course and task in the general literature and it occurs in all these areas and more in the CALL sphere where instructional design, website design, interface design and screen design are just some of the additional points of focus. This paper aims to look at CALL design in more detail. It places a particular emphasis on describing the discourse, products and processes of design in CALL. It looks at what we have learnt about design and points to areas th

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Beckermann, Thomas M., Wentian Luo, Catherine M. Wilson, Ruth Ann Veach, and Matthew H. Wilson. "Cognate restriction of transposition by piggyBac-like proteins." Nucleic Acids Research 49, no. 14 (2021): 8135–44. http://dx.doi.org/10.1093/nar/gkab578.

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Abstract Mobile genetic elements have been harnessed for gene transfer for a wide variety of applications including generation of stable cell lines, recombinant protein production, creation of transgenic animals, and engineering cell and gene therapy products. The piggyBac transposon family includes transposase or transposase-like proteins from a variety of species including insect, bat and human. Recently, human piggyBac transposable element derived 5 (PGBD5) protein was reported to be able to transpose piggyBac transposons in human cells raising possible safety concerns for piggyBac-mediated

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Ng, Martin Y., Hong Li, Mikel D. Ghelfi, Yale E. Goldman, and Barry S. Cooperman. "Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms." Proceedings of the National Academy of Sciences 118, no. 2 (2021): e2020599118. http://dx.doi.org/10.1073/pnas.2020599118.

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During protein synthesis, nonsense mutations, resulting in premature stop codons (PSCs), produce truncated, inactive protein products. Such defective gene products give rise to many diseases, including cystic fibrosis, Duchenne muscular dystrophy (DMD), and some cancers. Small molecule nonsense suppressors, known as TRIDs (translational read-through–inducing drugs), stimulate stop codon read-through. The best characterized TRIDs are ataluren, which has been approved by the European Medicines Agency for the treatment of DMD, and G418, a structurally dissimilar aminoglycoside. Previously [1], we

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KRETCHMER, NORMAN. "Why Not Have More Milk?" Pediatrics 88, no. 5 (1991): 1056–57. http://dx.doi.org/10.1542/peds.88.5.1056.

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In the past, biological products derived from the human had to be extracted or isolated from bulk materials, but now, with genetic engineering, gross amounts can be prepared by placing the appropriate gene in the genome of a friendly bacterium. Genetic engineering is a major scientific advance of our time and has made major contributions to medicine. Prominent products of this exciting biological advance are insulin, growth hormone, and interferon. The principle of genetic engineering is simple. A foreign gene is inserted into the genome of a bacterium, and the bacterium uses the gene as a tem

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Ohneck, Elizabeth A., Maira Goytia, Corinne E. Rouquette-Loughlin, et al. "Overproduction of the MtrCDE Efflux Pump in Neisseria gonorrhoeae Produces Unexpected Changes in Cellular Transcription Patterns." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 724–26. http://dx.doi.org/10.1128/aac.04148-14.

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ABSTRACTThe global consequence of drug efflux gene overexpression in bacteria has not been specifically analyzed because strains showing high-level expression typically have mutations in genes encoding regulatory proteins that control other genes. Results from a transcriptional profiling study performed with a strain ofNeisseria gonorrhoeaethat is capable of high-level transcription of themtrCDEefflux pump operon independently of control by cognate regulatory proteins revealed that its overexpression has ramifications for systems other than drug efflux.

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Jalinot, P., B. Devaux, and C. Kédinger. "The abundance and in vitro DNA binding of three cellular proteins interacting with the adenovirus EIIa early promoter are not modified by the EIa gene products." Molecular and Cellular Biology 7, no. 10 (1987): 3806–17. http://dx.doi.org/10.1128/mcb.7.10.3806-3817.1987.

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Specific protein binding on the EIa-inducible adenovirus EIIa early (EIIaE) promoter was analyzed by the sensitive electrophoretic band-shift assay and by protection against DNase I digestion. Three factors were identified, and precise mapping of the cognate-binding sites revealed their correspondence to promoter elements essential for constitutive EIIaE transcription. One binds to the major upstream element located between -82 and -64 (with respect to the major EIIaE cap site), another appears to interact with sequences on either side of this region, and the last one binds to an element locat

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Jalinot, P., B. Devaux, and C. Kédinger. "The abundance and in vitro DNA binding of three cellular proteins interacting with the adenovirus EIIa early promoter are not modified by the EIa gene products." Molecular and Cellular Biology 7, no. 10 (1987): 3806–17. http://dx.doi.org/10.1128/mcb.7.10.3806.

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Specific protein binding on the EIa-inducible adenovirus EIIa early (EIIaE) promoter was analyzed by the sensitive electrophoretic band-shift assay and by protection against DNase I digestion. Three factors were identified, and precise mapping of the cognate-binding sites revealed their correspondence to promoter elements essential for constitutive EIIaE transcription. One binds to the major upstream element located between -82 and -64 (with respect to the major EIIaE cap site), another appears to interact with sequences on either side of this region, and the last one binds to an element locat

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Gahete, Manuel D., David Rincón-Fernández, Alicia Villa-Osaba, et al. "Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight." Journal of Endocrinology 220, no. 1 (2013): R1—R24. http://dx.doi.org/10.1530/joe-13-0391.

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Ghrelin is a 28-amino acid acylated hormone, highly expressed in the stomach, which binds to its cognate receptor (GHSR1a) to regulate a plethora of relevant biological processes, including food intake, energy balance, hormonal secretions, learning, inflammation, etc. However, ghrelin is, in fact, the most notorious component of a complex, intricate regulatory system comprised of a growing number of alternative peptides (e.g. obestatin, unacylated ghrelin, and In1-ghrelin, etc.), known (GHSRs) and, necessarily unknown receptors, as well as modifying enzymes (e.g. ghrelin-O-acyl-transferase), w

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Roy, Bijoyita, John D. Leszyk, David A. Mangus, and Allan Jacobson. "Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3." Proceedings of the National Academy of Sciences 112, no. 10 (2015): 3038–43. http://dx.doi.org/10.1073/pnas.1424127112.

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Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise defective mRNA. To understand the mechanism of such nonsense suppression, we developed a yeast system that allows purification and sequence analysis of full-length readthrough products arising as a consequence of endogenous readthrough or the compromised termination fidelity attributable to the loss of Up

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Kume, Shinichiro, Seiya Kato, Sho-ichi Yamagishi, et al. "Advanced Glycation End-Products Attenuate Human Mesenchymal Stem Cells and Prevent Cognate Differentiation Into Adipose Tissue, Cartilage, and Bone." Journal of Bone and Mineral Research 20, no. 9 (2005): 1647–58. http://dx.doi.org/10.1359/jbmr.050514.

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BARDWELL, A. Jane, Mahsa ABDOLLAHI, and Lee BARDWELL. "Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs." Biochemical Journal 378, no. 2 (2004): 569–77. http://dx.doi.org/10.1042/bj20031382.

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Anthrax lethal toxin is the major cause of death in systemic anthrax. Lethal toxin consists of two proteins: protective antigen and LF (lethal factor). Protective antigen binds to a cell-surface receptor and transports LF into the cytosol. LF is a metalloprotease that targets MKKs [MAPK (mitogen-activated protein kinase) kinases]/MEKs [MAPK/ERK (extracellular-signal-regulated kinase) kinases], cleaving them to remove a small N-terminal stretch but leaving the bulk of the protein, including the protein kinase domain, intact. LF-mediated cleavage of MEK1 and MKK6 has been shown to inhibit signal

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Mock, Jacqueline, Marco Stringhini, Alessandra Villa, Michael Weller, Tobias Weiss, and Dario Neri. "An engineered 4-1BBL fusion protein with “activity on demand”." Proceedings of the National Academy of Sciences 117, no. 50 (2020): 31780–88. http://dx.doi.org/10.1073/pnas.2013615117.

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Engineered cytokines are gaining importance in cancer therapy, but these products are often limited by toxicity, especially at early time points after intravenous administration. 4-1BB is a member of the tumor necrosis factor receptor superfamily, which has been considered as a target for therapeutic strategies with agonistic antibodies or using its cognate cytokine ligand, 4-1BBL. Here we describe the engineering of an antibody fusion protein, termed F8-4-1BBL, that does not exhibit cytokine activity in solution but regains biological activity on antigen binding. F8-4-1BBL bound specifically

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Gamage, Akshamal Mihiranga, Guanghou Shui, Markus R. Wenk, and Kim Lee Chua. "N-Octanoylhomoserine lactone signalling mediated by the BpsI–BpsR quorum sensing system plays a major role in biofilm formation of Burkholderia pseudomallei." Microbiology 157, no. 4 (2011): 1176–86. http://dx.doi.org/10.1099/mic.0.046540-0.

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The genome of Burkholderia pseudomallei encodes three acylhomoserine lactone (AHL) quorum sensing systems, each comprising an AHL synthase and a signal receptor/regulator. The BpsI–BpsR system produces N-octanoylhomoserine lactone (C8HL) and is positively auto-regulated by its AHL product. The products of the remaining two systems have not been identified. In this study, tandem MS was used to identify and quantify the AHL species produced by three clinical B. pseudomallei isolates – KHW, K96243 and H11 – three isogenic KHW mutants that each contain a null mutation in an AHL synthase gene, and

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Kim, Heenam, and Stephen K. Farrand. "Opine Catabolic Loci from Agrobacterium Plasmids Confer Chemotaxis to Their Cognate Substrates." Molecular Plant-Microbe Interactions® 11, no. 2 (1998): 131–43. http://dx.doi.org/10.1094/mpmi.1998.11.2.131.

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Opines are carbon compounds produced by crown galls and hairy roots induced by Agrobacterium tumefaciens and A. rhizogenes, respectively. These novel condensation products of plant metabolic intermediates are utilized as nutritional sources by the Agrobacterium strains that induced the growths. Thus, opines are thought to favor the propagation of agrobacteria in the tumorsphere. Certain Agrobacterium strains were chemoattracted to opines. The chemotactic activities to octopine, to nopaline, to manno-pine, and to agrocinopines A+B were dependent on the type of the Ti plasmid present in the bact

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Dakhel, Sheila, Christian Lizak, Mattia Matasci, et al. "An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease." International Journal of Molecular Sciences 22, no. 18 (2021): 10020. http://dx.doi.org/10.3390/ijms221810020.

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Antibody-cytokine fusion proteins (immunocytokines) are gaining importance for cancer therapy, but those products are often limited by systemic toxicity related to the activity of the cytokine payload in circulation and in secondary lymphoid organs. Tumor necrosis factor (TNF) is used as a pro-inflammatory payload to trigger haemorrhagic necrosis and boost anti-cancer immunity at the tumor site. Here we describe a depotentiated version of TNF (carrying the single point mutation I97A), which displayed reduced binding affinity to its cognate receptor tumor necrosis factor receptor 1 (TNFR-1) and

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Higby, Eve, Seamus Donnelly, Jungmee Yoon, and Loraine K. Obler. "The effect of second-language vocabulary on word retrieval in the native language." Bilingualism: Language and Cognition 23, no. 4 (2019): 812–24. http://dx.doi.org/10.1017/s136672891900049x.

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AbstractWhen bilinguals produce words in one language, their translation equivalents in the other language are thought to be activated as well. A common assumption is that this parallel co-activation produces interference, which slows down word retrieval. The current study aimed to evaluate the assumption of lexical interference during word retrieval by testing whether late Portuguese–English bilinguals were slower to name pictures in their native language when they knew the word in their second language compared to when they only knew the native language label. Instead of interfering with pro

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Di Nitto, Cesare, Ettore Gilardoni, Jacqueline Mock та ін. "An Engineered IFNγ-Antibody Fusion Protein with Improved Tumor-Homing Properties". Pharmaceutics 15, № 2 (2023): 377. http://dx.doi.org/10.3390/pharmaceutics15020377.

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Interferon-gamma (IFNγ) is one of the central cytokines produced by the innate and adaptive immune systems. IFNγ directly favors tumor growth control by enhancing the immunogenicity of tumor cells, induces IP-10 secretion facilitating (CXCR3+) immune cell infiltration, and can prime macrophages to an M1-like phenotype inducing proinflammatory cytokine release. We had previously reported that the targeted delivery of IFNγ to neoplastic lesions may be limited by the trapping of IFNγ-based products by cognate receptors found in different organs. Here we describe a novel fusion protein consisting

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Reid, Anne N., and Chris Whitfield. "Functional Analysis of Conserved Gene Products Involved in Assembly of Escherichia coli Capsules and Exopolysaccharides: Evidence for Molecular Recognition between Wza and Wzc for Colanic Acid Biosynthesis." Journal of Bacteriology 187, no. 15 (2005): 5470–81. http://dx.doi.org/10.1128/jb.187.15.5470-5481.2005.

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ABSTRACT Group 1 capsular polysaccharides (CPSs) of Escherichia coli and some loosely cell-associated exopolysaccharides (EPSs), such as colanic acid, are assembled by a Wzy-dependent polymerization system. In this biosynthesis pathway, Wza, Wzb, and Wzc homologues are required for surface expression of wild-type CPS or EPS. Multimeric complexes of Wza in the outer membrane are believed to provide a channel for polymer export; Wzc is an inner membrane tyrosine autokinase and Wzb is its cognate phosphatase. This study was performed to determine whether the Wza, Wzb, and Wzc proteins for colanic

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Zhong, Hangkai. "Angle calculation method based on Cognex binary image processing and edge tool positioning." Applied and Computational Engineering 46, no. 1 (2024): 176–88. http://dx.doi.org/10.54254/2755-2721/46/20241314.

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Aiming at the problem of no suitable measurement method for the angle between a product's upper and lower cylinder axes in a specific horizontal rotation position, a calculation method based on the Cognex vision system for automatic angle measurement was proposed. This algorithm uses binary image processing technology to reduce interference in product implementation caused by variations in surface roughness and resulting inconsistencies in the reflection effect. The ability to perform robust image feature searching is thereby built upon. It utilizes edge tools to locate the points on either si

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