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Journal articles on the topic 'Cognition – Effect of drugs on'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

del Ser, Teodoro, María-Ascensión Zea, Meritxell Valentí, et al. "Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people." Journal of Psychopharmacology 33, no. 8 (2019): 965–74. http://dx.doi.org/10.1177/0269881119857206.

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Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years wa

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Aldenkamp, Albert P. "Effects of Antiepileptic Drugs on Cognition." Epilepsia 42 (March 2001): 46–49. http://dx.doi.org/10.1046/j.1528-1157.2001.00516.x.

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Anderson, Beth M., Matthew Rizzo, Robert I. Block, Godfrey D. Pearlson, and Daniel S. O'Leary. "Sex, Drugs, and Cognition: Effects of Marijuana." Journal of Psychoactive Drugs 42, no. 4 (2010): 413–24. http://dx.doi.org/10.1080/02791072.2010.10400704.

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David, Michael, Martina Del Giovane, Kathy Liu, et al. "041 Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: systematic review and meta-analysis." Journal of Neurology, Neurosurgery & Psychiatry 93, no. 9 (2022): e2.236. http://dx.doi.org/10.1136/jnnp-2022-abn2.85.

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BackgroundDysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease. This results in a low-noradrenergic state in some patients, which contributes to cognitive and neuropsychi- atric symptoms. We aimed to assess the efficacy of noradrenergic drugs for improving these symptoms.MethodsThe MEDLINE, Embase, and ClinicalTrials.gov databases were searched from 1980 to December 2021. We generated pooled estimates using random effects meta-analyses.Results19 randomised controlled trials, of which six studies were of ‘good’ quality, with seven ‘fair’ and six ‘poor’, in

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Priyavarshini R, Shweta Betala, and Amit B Patil. "Formulation and Evaluation of fixed dose combination of Nootropic drugs." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2895–908. http://dx.doi.org/10.26452/ijrps.v11i3.2374.

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Cognitive functions are the critical brain functions responsible for the effective learning and understanding in the humans. They are responsible for various functions like attention, memory, reasoning and in turn helps to improve knowledge. Cognitive impairment is majorly seen in elderly as the brain is prone to neuro degradation. It may also occur in young adults due to poor diet or exercise. Improving cognition is of utmost importance and can be done by the use of cognition enhancers like Nootropics. This class of drugs is said to act by various mechanisms, which in turn leads to the better

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Bishara, Delia, Daniel Harwood, Justin Sauer, and David M. Taylor. "Anticholinergic effect on cognition (AEC) of drugs commonly used in older people." International Journal of Geriatric Psychiatry 32, no. 6 (2016): 650–56. http://dx.doi.org/10.1002/gps.4507.

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ATTOH-MENSAH, Elpidio K., Gilles Loggia, Remy Morello, et al. "ANTICHOLINERGIC DRUGS: CUT-OFF FOR IMPAIRED COGNITION AND MOBILITY IN SENIORS." Innovation in Aging 3, Supplement_1 (2019): S92—S93. http://dx.doi.org/10.1093/geroni/igz038.351.

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Abstract Background and Objectives: Anticholinergic drugs are commonly prescribed in older adults despite growing evidence of their adverse outcomes. We aimed to improve knowledge about deleterious effects of anticholinergic drugs on both cognition and mobility, in particular whether there is a threshold value for the number of anticholinergic drugs or for the anticholinergic burden leading to mobility or cognitive impairment. Methods: 177 community-dwelling individuals aged 55 years or over, with a fall history in the previous year, took part in the study. Anticholinergic drugs were identifie

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Cohen, Koby, and Aviv Weinstein. "The Effects of Cannabinoids on Executive Functions: Evidence from Cannabis and Synthetic Cannabinoids—A Systematic Review." Brain Sciences 8, no. 3 (2018): 40. http://dx.doi.org/10.3390/brainsci8030040.

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Background—Cannabis is the most popular illicit drug in the Western world. Repeated cannabis use has been associated with short and long-term range of adverse effects. Recently, new types of designer-drugs containing synthetic cannabinoids have been widespread. These synthetic cannabinoid drugs are associated with undesired adverse effects similar to those seen with cannabis use, yet, in more severe and long-lasting forms. Method—A literature search was conducted using electronic bibliographic databases up to 31 December 2017. Specific search strategies were employed using multiple keywords (e

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Harvey, N. S. "Serial Cognitive Profiles in Levodopa-induced Hypersexuality." British Journal of Psychiatry 153, no. 6 (1988): 833–36. http://dx.doi.org/10.1192/bjp.153.6.833.

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A patient with recent-onset Parkinson's disease was tested for mood, physical disability, and cognition, before treatment and then during and after a period of levodopa-induced hypersexuality. The effects of different anti-Parkinsonian drugs on cognition and behaviour are described. The unique cognitive data from this case support the hypothesis that hypersexuality is a manifestation of enhanced libido and not frontal disinhibition.

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Malabadi, Ravindra B., Kiran P. Kolkar, Neelambika T. Meti, and Raju K. Chalannavar. "Recent updates on the role of herbal medicine for Alzheimer's disease (Dementia)." International Journal of Current Research in Biosciences and Plant Biology 8, no. 1 (2021): 14–45. http://dx.doi.org/10.20546/ijcrbp.2021.801.002.

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This review paper highlights the use of medicinal plants in the management of Alzheimer's disease and memory deficit. Alzheimer’s disease is the most common form of dementia, a serious brain disorder that impacts daily living through memory loss and cognitive changes. Alzheimer's disease is also age-related neurodegenerative disorders caused by progressive loss of structure or function of neurons, resulting in neuronal cell death. Alzheimer's patients have an acetylcholine deficiency. Stressful conditions, free radicle scavanging and oxidation are often associated with loss of memory and cogni

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Abou-Khalil, Bassel, and Rima Abou-Khalil. "Seizure Disorders and the Effects of Antiepileptic Medications on Cognitive-Communicative Function." Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders 25, no. 2 (2015): 47–60. http://dx.doi.org/10.1044/nnsld25.2.47.

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Purpose Review effects of epilepsy and its treatment on cognitive-communicative function. Method We searched PubMed and extracted relevant information. Results Epilepsy is a disorder characterized by recurrent unprovoked seizures. Epilepsy is commonly associated with cognitive disturbances in between seizures, most commonly memory dysfunction. Other cognitive disturbances may be seen, particularly auditory naming when epilepsy starts in the dominant temporal lobe. While control of seizures is expected to improve the cognitive consequences, antiepileptic drugs themselves may be associated with

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Schilt, T., M. M. L. de Win, G. Jager, et al. "Specific effects of ecstasy and other illicit drugs on cognition in poly-substance users." Psychological Medicine 38, no. 9 (2007): 1309–17. http://dx.doi.org/10.1017/s0033291707002140.

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BackgroundA large number of studies, reviews and meta-analyses have reported cognitive deficits in ecstasy users. However most ecstasy users are polydrug users, and therefore it cannot be excluded that these deficits are (partly) the result of drugs other than ecstasy. The current study, part of the Netherlands XTC Toxicity (NeXT) study, investigates the specific sustained effects of ecstasy relative to amphetamine, cocaine and cannabis on the brain using neuropsychological examination.MethodA stratified sample of 67 subjects with such a variation in type and amount of drug use was included th

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Eddy, Clare M., Hugh E. Rickards, and Andrea E. Cavanna. "The cognitive impact of antiepileptic drugs." Therapeutic Advances in Neurological Disorders 4, no. 6 (2011): 385–407. http://dx.doi.org/10.1177/1756285611417920.

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Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing. On the other hand, some agents may serve to enhance cognitive function. In this review paper, we highlight the range of effects on cognition linked to a variety of newer and older AEDs, encompassing key alterations in both specific executive abilities and broad

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Sumiyoshi, T., Y. Higuchi, T. Itoh, et al. "Effect of Perospirone on p300 Electrophysiological Activity and Social Cognition in Schizophrenia: A Three-dimensional Analysis with (s)loreta." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71436-1.

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The purpose of this study was to determine if perospirone, a second generation antipsychotic drug and partial agonist at serotonin-5-HT1A receptors, enhances electrophysiological activity, such as event-related potentials (ERPs), in frontal brain regions, as well as cognitive function in subjects with schizophrenia. P300 current source images were obtained by means of standardized low resolution brain electromagnetic tomography (sLORETA) before and after treatment with perospirone for 6 months. Perospirone significantly increased P300 current source density in the left superior frontal gyrus,

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Goya, Luis, Ricardo San Román, and Sonia de Pascual-Teresa. "Polyphenols’ Effect on Cerebrovascular Health." Current Medicinal Chemistry 29, no. 6 (2022): 1029–44. http://dx.doi.org/10.2174/0929867328666211129123459.

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: Polyphenols are a wide group of plant components that include a high number of individual compounds and are present in foods, dietary supplements, and drugs. Many of them have shown pharmacological effects, are used in cardiovascular disease prevention, and not as many have been assayed in cancer treatment or co-treatment. In the last few years, however, the research on polyphenols' implications in healthy aging, especially in neurodegeneration and cognition improvement, has increased dramatically. Most of the results found in this sense are again related to the capacity of some specific pol

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Huehnchen, Petra, Antonia van Kampen, Wolfgang Boehmerle, and Matthias Endres. "Cognitive impairment after cytotoxic chemotherapy." Neuro-Oncology Practice 7, no. 1 (2019): 11–21. http://dx.doi.org/10.1093/nop/npz052.

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Abstract Background Neurotoxicity is a frequent side effect of cytotoxic chemotherapy and affects a large number of patients. Despite the high medical need, few research efforts have addressed the impact of cytotoxic agents on cognition (ie, postchemotherapy cognitive impairment; PCCI). One unsolved question is whether individual cytotoxic drugs have differential effects on cognition. We thus examine the current state of research regarding PCCI. Neurological symptoms after targeted therapies and immunotherapies are not part of this review. Methods A literature search was conducted in the PubMe

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Foster, Emma, Charles B. Malpas, Karena Ye, et al. "Antiepileptic drugs are not independently associated with cognitive dysfunction." Neurology 94, no. 10 (2020): e1051-e1061. http://dx.doi.org/10.1212/wnl.0000000000009061.

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ObjectiveTo test the hypothesis that individual antiepileptic drugs (AEDs) are not associated with cognitive impairment beyond other clinically relevant factors, we performed a cross-sectional study of patients admitted to an inpatient video-EEG monitoring unit.MethodsWe prospectively enrolled patients admitted to an inpatient specialist epilepsy program between 2009 and 2016. Assessments included objective cognitive function, quality of life subscales for subjective cognitive function, and questionnaires for anxiety and depressive symptoms. Bayesian model averaging identified predictors of co

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Rai, Jayant, Preeti P. Yadav, Richa Verma, and Mayur Chaudhari. "Effect of anti-epileptic drugs on cognitive functions: a prospective study in individuals with newly diagnosed complex partial seizure and generalized tonic clonic seizure." International Journal of Basic & Clinical Pharmacology 6, no. 4 (2017): 855. http://dx.doi.org/10.18203/2319-2003.ijbcp20171092.

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Background: Epilepsy, the third most common neurologic disorder, deteriorates cognitive functions of the patients. Approximately 1% of the world’s population is suffering from epilepsy. Opinions regarding impact of anti-epileptic drugs on cognition are divided. So, this study was designed to assess the impact of anti-epileptic drugs on cognitive performance of patients with complex partial seizure and generalized tonic clonic seizure in Department of Medicine, at Government Medical College, Surat, Gujarat, India.Methods: In present study, cognitive functions were assessed in 50 patients of new

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Bootsma, Hans-Peter R., Albert P. Aldenkamp, Leonie Diepman, et al. "The Effect of Antiepileptic Drugs on Cognition: Patient Perceived Cognitive Problems of Topiramate versus Levetiracetam in Clinical Practice." Epilepsia 47, s2 (2006): 24–27. http://dx.doi.org/10.1111/j.1528-1167.2006.00683.x.

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Ilieva, Irena P., Cayce J. Hook, and Martha J. Farah. "Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis." Journal of Cognitive Neuroscience 27, no. 6 (2015): 1069–89. http://dx.doi.org/10.1162/jocn_a_00776.

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The use of prescription stimulants to enhance healthy cognition has significant social, ethical, and public health implications. The large number of enhancement users across various ages and occupations emphasizes the importance of examining these drugs' efficacy in a nonclinical sample. The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In addition, we exa

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AKAHO, RIE. "The effects of antiepileptic drugs on cognition in normal volunteers." Psychiatry and Clinical Neurosciences 50, no. 2 (1996): 61–69. http://dx.doi.org/10.1111/j.1440-1819.1996.tb01665.x.

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Meltzer, Herbert Y. "Beyond Control of Acute Exacerbation: Enhancing Affective and Cognitive Outcomes." CNS Spectrums 8, S2 (2003): 16–18. http://dx.doi.org/10.1017/s1092852900008142.

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ABSTRACTFrom the perspective of efficacy, the main advantages of the group of new antipsychotic drugs, including ziprasidone, clozapine, quetiapine, olanzapine, and risperidone, are their ability to improve cognitive function. Other advantages are more selective, eg, clozapine in treatment-resistant schizophrenia, while the advantages for positive and negative symptoms in neuroleptic responsive patients are modest and sometimes difficult to demonstrate. The advantage for cognitive function is important because of abundant evidence that cognitive function is a key predictor of work and social f

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Kurz, Alexander F., Stefan Leucht, and Nicola T. Lautenschlager. "The clinical significance of cognition-focused interventions for cognitively impaired older adults: a systematic review of randomized controlled trials." International Psychogeriatrics 23, no. 9 (2011): 1364–75. http://dx.doi.org/10.1017/s1041610211001001.

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ABSTRACTBackground: Cognitive stimulation, training or rehabilitation can achieve modest, skill-specific gains in cognitively healthy older adults. With regard to the limited efficacy of currently available anti-dementia drugs it is crucial to investigate whether such treatments also provide clinically meaningful benefits to cognitively impaired older individuals.Methods: We conducted a systematic review of randomized controlled trials evaluating cognition-focused interventions in participants with mild cognitive impairment or dementia. Meta-analytic strategies were used to calculate effect si

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Ho, Jean K., Frank Moriarty, Jennifer J. Manly, et al. "Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis." Hypertension 78, no. 3 (2021): 629–43. http://dx.doi.org/10.1161/hypertensionaha.121.17049.

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Hypertension is an established risk factor for cognitive decline and dementia in older adults, highlighting the potential importance of antihypertensive treatments in prevention efforts. Work surrounding antihypertensive treatments has suggested possible salutary effects on cognition and neuropathology. Several studies have specifically highlighted renin-angiotensin system drugs, including AT1-receptor blockers and angiotensin-converting-enzyme inhibitors, as potentially benefiting cognition in later life. A small number of studies have further suggested renin-angiotensin system drugs that cro

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de la Colina, Adrian Noriega, Helen-Maria Vasiliadis, Djamal Berbiche, Louis Bherer, Helene Girouard, and Navin Kaushal. "IMPACT OF SEX AND ANTIHYPERTENSIVE MEDICATION ON GLOBAL COGNITION IN PRIMARY CARE OLDER ADULTS." Innovation in Aging 6, Supplement_1 (2022): 690–91. http://dx.doi.org/10.1093/geroni/igac059.2533.

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Abstract Hypertension is one of the strongest modifiable risk factors for the development of cognitive impairment and dementia. However, there are conflicting reports regarding which class of antihypertensive medication is the best for reducing the risk of cognitive decline. The objective of this study is to determine whether sex determines the pharmacological therapy that is the most effective in preserving cognitive outcomes. This study examined 1607 participants from the ESA Services Study, a longitudinal survey of older adults over 65 years old in Quebec-Canada. They were examined for the

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Stuhec, M., J. Keuschler, J. Serra-Mestres, and M. Isetta. "Effects of different antihypertensive medication groups on cognitive function in older patients: A systematic review." European Psychiatry 46 (October 2017): 1–15. http://dx.doi.org/10.1016/j.eurpsy.2017.07.015.

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AbstractBackground:Chronic hypertension has been associated with an increased risk of cognitive decline. Although a link between hypertension and cognitive decline has been established, there is less evidence supported by systematic reviews. The main aim was to compare different antihypertensive drug groups in relation to their effect on cognition in older patients without established dementia using a systematic review.Method:A systematic search in Medline and Embase through to January 2017 was used to identify randomized controlled clinical trials (RCTs) studying the impact of different antih

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Moran, Mark. "Drug's Effect on Cognition Could Be Treatment Advance." Psychiatric News 42, no. 19 (2007): 17. http://dx.doi.org/10.1176/pn.42.19.0017.

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Anam, Seeba, Scott Hunter, and Khalid Afzal. "The Effects of Antiepileptic Drugs on Pediatric Cognition, Mood, and Behavior." Journal of Pediatric Epilepsy 06, no. 01 (2016): 003–18. http://dx.doi.org/10.1055/s-0036-1584935.

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Maier, Larissa J., and Michael P. Schaub. "The Use of Prescription Drugs and Drugs of Abuse for Neuroenhancement in Europe." European Psychologist 20, no. 3 (2015): 155–66. http://dx.doi.org/10.1027/1016-9040/a000228.

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Abstract. Pharmacological neuroenhancement, defined as the misuse of prescription drugs, illicit drugs, or alcohol for the purpose of enhancing cognition, mood, or prosocial behavior, is not widespread in Europe – nevertheless, it does occur. Thus far, no drug has been proven as safe and effective for cognitive enhancement in otherwise healthy individuals. European studies have investigated the misuse of prescription and illicit stimulants to increase cognitive performance as well as the use of tranquilizers, alcohol, and cannabis to cope with stress related to work or education. Young people

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Sayyah, Mehdi, Kaveh Eslami, Shabnam AlaiShehni, and Leila Kouti. "Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder." Psychiatry Journal 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5480391.

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Objectives. Identification of adverse effects of selective serotonin reuptake inhibitors (SSRIs) is of great importance due to their extensive use in medicine. Some studies have reported the effects of SSRIs on cognitive functions, but the results are conflicting. This study was designed to assess the effect of these drugs on cognition of patients with depression or obsessive-compulsive disorder (OCD).Methods. Patients with depression or OCD, naïve to therapy, and candidates of receiving one drug from SSRI class, voluntarily, entered this study. Mini-Mental State Examination (MMSE) test was th

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M Yelanchezian, Y. Mukish, Henry J. Waldvogel, Richard L. M. Faull, and Andrea Kwakowsky. "Neuroprotective Effect of Caffeine in Alzheimer’s Disease." Molecules 27, no. 12 (2022): 3737. http://dx.doi.org/10.3390/molecules27123737.

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Alzheimer’s disease (AD) is the leading cause of dementia, predicted to be the most significant health burden of the 21st century, with an estimated 131.5 million dementia patients by the year 2050. This review aims to provide an overview of the effect of caffeine on AD and cognition by summarizing relevant research conducted on this topic. We searched the Web of Science core collection and PubMed for studies related to the effect of caffeine on AD and cognition using title search terms: caffeine; coffee; Alzheimer’s; cognition. There is suggestive evidence from clinical studies that caffeine

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Bhushan, Bharat, Jaram Singh, and Rajveer Sason. "Endurance Effect of Rasayana Drug “Ashwagandha-Withania Somnifera” in Athletes-A Review Article." International Research Journal of Ayurveda & Yoga 05, no. 10 (2022): 87–91. http://dx.doi.org/10.47223/irjay.2022.51014.

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Doping drugs or performance-enhancing substances are illicit substances used to improve performance. These substances could be toxic and have a negative effect on athlete's health. Rasayana therapy can be given to healthy people to boost health and increase strength as well as to sick people to improve their immunological resistance. Researchers have discovered that Ashwagandha and other Rasayana drugs have nootropic (improving cognition and brain function) advantages in addition to immunomodulatory, adaptogenic, antioxidant, anti-aging, nutritional, anabolic, haemopoetic, and anti-ageing char

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Hulsken, Sjoerd, Antje Märtin, M. Hasan Mohajeri, and Judith Regina Homberg. "Food-derived serotonergic modulators: effects on mood and cognition." Nutrition Research Reviews 26, no. 2 (2013): 223–34. http://dx.doi.org/10.1017/s0954422413000164.

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The most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (MAO) inhibitors, enhancing serotonin levels in the brain. However, side-effects have been reported for these drugs. Because serotonin levels in the brain are dependent on the availability of the food-derived precursor tryptophan, foods such as chicken, soyabeans, cereals, tuna, nuts and bananas may serve as an alternative to improve mood and cognition. Here we discuss the effects of high- or low-tryptophan-containing food, as well as plant extracts with a modest monoam

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GOLIGHTLY, K. L., J. A. LLOYD, J. E. HOBSON, P. GALLAGHER, G. MERCER, and A. H. YOUNG. "Acute tryptophan depletion in schizophrenia." Psychological Medicine 31, no. 1 (2001): 75–84. http://dx.doi.org/10.1017/s0033291799003062.

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Background. Brain 5-hydroxytryptamine (5-HT) function is implicated in the pathophysiology of schizophrenia and the action of new generation antipsychotic drugs. By the method of acute tryptophan depletion (ATD) 5-HT can be selectively manipulated. The aim of this study was to examine the effects of ATD on symptoms, mood and cognition in schizophrenic patients.Methods. Twenty-eight schizophrenic patients participated in a within subject, double-blind, placebo-controlled counterbalanced cross-over study. Patients with a concurrent DSM-IV axis I diagnosis were excluded. Symptoms, mood and cognit

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Ballesteros, Alejandro, Ana M. Sánchez-Torres, Jose M. López-Ilundain, et al. "Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?" Psychological Medicine 48, no. 13 (2018): 2247–56. http://dx.doi.org/10.1017/s0033291717003774.

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AbstractBackgroundCognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups.MethodsTwo hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinerg

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Das, Soumitra, Seshadri Sekhar Chatterjee, and Barikar Chandrappa Malathesh. "Anticholinergic medications even in therapeutic range can cause recurrence of psychosis." General Psychiatry 33, no. 4 (2020): e100235. http://dx.doi.org/10.1136/gpsych-2020-100235.

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Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome (EPS). Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium. Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature. Here, we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS, and each time had worsening of psychosis with intact cognition. We then discussed the possible neurobiological explanation with special ref

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Weiser, Mark, Michal Shneider-Beeri, Nitza Nakash, et al. "Improvement in cognition associated with novel antipsychotic drugs: a direct drug effect or reduction of EPS?" Schizophrenia Research 46, no. 2-3 (2000): 81–89. http://dx.doi.org/10.1016/s0920-9964(00)00025-6.

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Ehrt, U., K. Broich, J. P. Larsen, C. Ballard, and D. Aarsland. "Use of drugs with anticholinergic effect and impact on cognition in Parkinson's disease: a cohort study." Journal of Neurology, Neurosurgery & Psychiatry 81, no. 2 (2009): 160–65. http://dx.doi.org/10.1136/jnnp.2009.186239.

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Chamberlain, Samuel R., Ulrich Müller, Julia B. Deakin, et al. "Lack of deleterious effects of buspirone on cognition in healthy male volunteers." Journal of Psychopharmacology 21, no. 2 (2007): 210–15. http://dx.doi.org/10.1177/0269881107068066.

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Buspirone is a serotonin 5-HT1A receptor agonist licensed for the treatment of anxiety. Other anxiolytic drugs such as benzodiazepines show significant sedative and other unwanted effects on cognition. Studies to date have yet to investigate cognitive effects of buspirone using well-validated computerized tests. The aim of this study was to assess acute subjective and cognitive effects of buspirone in healthy volunteers. Sixty healthy male volunteers received 20mg buspirone, 30mg buspirone, or placebo per os in a double-blind parallel groups design (N=20 per group). Subjective ratings (visual

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Bittencourt, Paulo R. M., Maria Joana Mader, Monica M. Bigarella, et al. "Cognitive functions, epileptic syndromes and antiepileptic drugs." Arquivos de Neuro-Psiquiatria 50, no. 1 (1992): 24–30. http://dx.doi.org/10.1590/s0004-282x1992000100005.

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Cognitive function of patients on monotherapy specific for their epileptic syndrome has been studied infrequently. We evaluated 7 patients with symptomatic localised epilepsies (SEL) on phenytoin aged 30±12 (mean±standard deviation) years, 8 with idiopathic generalised epilepsies on sodium valproate aged 18±4 years, 16 with SEL on carbamazepine aged 28±11 years, and 35 healthy controls aged 27±11 years. All subjects were of normal intelligence, educated appropriately to age, and led productive lives in the community. Two of the patients on carbamazepine and one on valproate had less than five

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Ramirez Dominguez, M. D. L. C., I. Prieto Sánchez, M. Nuñez Caro, and L. Hernandez Gonzalez. "New drugs: Use of everyday substances as substances of abuse." European Psychiatry 33, S1 (2016): S313—S314. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1071.

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IntroductionEmerging drugs are a growing problem, of which we have little information and clinical experience and pose a challenge in everyday clinical practice because many are not detectable with the test at our disposal and its effect on cognition and behavior are not well known.MethodsConduct a thorough literature review of all the material in this regard has been published both in high impact journals and in the last International Congress of Dual Pathology.ResultsThere are many and varied new substances used for harmful/abuse consumption mainly for their sedative effects and/or hallucino

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Zang, Cai-Xia, Xiu-Qi Bao, Lin Li та ін. "The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity". American Journal of Chinese Medicine 46, № 02 (2018): 389–405. http://dx.doi.org/10.1142/s0192415x18500192.

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Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. Although the exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation have been recognized as influential factors. Current drugs that are designed to address only a single target are unable to mitigate or prevent the progression of this complicated disease, so new disease-modifying drugs are urgently needed. Chinese herbs with thousand years of effective usage might be a good source for potential drugs. Gardenia jasminoides J. E

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Chyr, Jacqueline, Haoran Gong, and Xiaobo Zhou. "DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer’s Disease." Biomolecules 12, no. 2 (2022): 196. http://dx.doi.org/10.3390/biom12020196.

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Alzheimer’s disease (AD) is the leading cause of age-related dementia, affecting over 5 million people in the United States and incurring a substantial global healthcare cost. Unfortunately, current treatments are only palliative and do not cure AD. There is an urgent need to develop novel anti-AD therapies; however, drug discovery is a time-consuming, expensive, and high-risk process. Drug repositioning, on the other hand, is an attractive approach to identify drugs for AD treatment. Thus, we developed a novel deep learning method called DOTA (Drug repositioning approach using Optimal Transpo

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Li, Jeffrey, and El-Sayed M. Abdel-Aal. "Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials." Molecules 26, no. 19 (2021): 5794. http://dx.doi.org/10.3390/molecules26195794.

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Emerging literature suggests that dietary lutein may have important functions in cognitive health, but there is not enough data to substantiate its effects in human cognition. The current study was intended to determine the overall effect of lutein on the main domains of cognition in the adult population based on available placebo randomized-controlled trials. Literature searches were conducted in PubMed, AGRICOLA, Scopus, MEDLINE, and EMBASE on 14 November 2020. The effect of lutein on complex attention, executive function and memory domains of cognition were assessed by using an inverse-vari

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Strik, Jacqueline J. M. H., Adriaan Honig, Edwin Klinkenberg, Jeanette Dijkstra, and Jelle Jolles. "Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction." Acta Neuropsychiatrica 18, no. 1 (2006): 1–6. http://dx.doi.org/10.1111/j.0924-2708.2006.00110.x.

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Background:As depression is a considerable risk factor for an unfavourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue.Objective:The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression.Methods:Cognitive performance of 54 depressed patients post first-MI, treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of trea

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Lodhi, Shruti, and Niruj Agrawal. "Neurocognitive problems in epilepsy." Advances in Psychiatric Treatment 18, no. 3 (2012): 232–40. http://dx.doi.org/10.1192/apt.bp.110.007930.

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SummaryCognitive dysfunction is one of the major contributors to the burden of epilepsy. It can significantly disrupt intellectual development in children and functional status and quality of life in adults. Epilepsy affects cognition through a number of mechanisms in complex interrelationship. Cognitive deficits in epilepsy may be treated indirectly through aggressive seizure control using anti-epileptic drugs or surgery, and by treating comorbid conditions such as depression. The beneficial effects of reducing seizures may offset the adverse cognitive side-effects of these therapies. Direct

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Shishmanova-Doseva, Michaela, Jana Tchekalarova, Zlatina Nenchovska, Natasha Ivanova, Katerina Georgieva, and Lyudmil Peychev. "The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model." Folia Medica 62, no. 4 (2020): 723–29. http://dx.doi.org/10.3897/folmed.62.e51473.

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Introduction: Epilepsy and antiepileptic drugs can affect negatively the cognitive abilities of patients. Aim: The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus.&nbsp; Materials and methods: Male Wistar rats were randomly divided into 6 groups and status epilepticus was evoked in half of them by a single i.p. administration of pilocarpine (Pilo) (320 mg/kg): Pilo-veh, Pilo-TPM (80 mg/kg) and Pilo-LCM (30 mg/kg). Matched naive rats were

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Allain, H., S. Schück, N. Mauduit, and M. Djemai. "Comparative effects of pharmacotherapy on the maintenance of cognitive function." European Psychiatry 16, S1 (2001): 35s—41S. http://dx.doi.org/10.1016/s0924-9338(00)00528-9.

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SummaryThe quality of human cognitive performance appears today as one of the main components of quality of life, whatever the age. Ageing by itself and most of the diseases affecting the central nervous system alter higher brain functions such as memory, vigilance and attention. Dementia is the most acute example, with a cascade of behavioral and psychological consequences (BPSD), which are the main cause of the caregiver’s burden and need specific pharmacotherapy. In this respect, the problem will be the choice of the best drug in situations such as wandering, agitation, violence, and scream

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Kotov, Aleksey Sergeyevich. "The effect of antiepileptic drugs on cognitive functions." Neurology, neuropsychiatry, Psychosomatics, no. 1S (March 30, 2013): 45. http://dx.doi.org/10.14412/2074-2711-2013-2489.

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Aini, Miza Rahmatika, and Hesty Puspitasari. "Terapi Menulis untuk Meningkatkan Kemampuan Kognitif Pecandu Narkoba di Lapas Dewasa Kota Blitar." ALFABETA: Jurnal Bahasa, Sastra, dan Pembelajarannya 4, no. 1 (2021): 56–64. http://dx.doi.org/10.33503/alfabeta.v4i1.1205.

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Drugs is the term for narcotics, psychotropic substances and other dangerous. The term often used is DRUGS (Narcotics, Alcohol, Psychotropics and other addictive substances) Around us today, there are a lot of addictive substances that are negative and very harmful to the body. Known as narcotics and illegal drugs. In this sophisticated modern era, drugs have become a problem for mankind in various parts of the world. Drugs that can destroy bright reasoning destroy body and soul, inevitably can threaten the future of mankind. In life, a critical step of the neurodevelopmental process, drug abu

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