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Journal articles on the topic 'Cogwheel'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 May 2022

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1

Ghiglione, Paolo, Roberto Mutani, and Adriano Chiò. "Cogwheel Rigidity." Archives of Neurology 62, no. 5 (May 1, 2005): 828. http://dx.doi.org/10.1001/archneur.62.5.828.

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2

Anstis, S. "The cogwheel illusion." Journal of Vision 3, no. 9 (March 16, 2010): 170. http://dx.doi.org/10.1167/3.9.170.

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3

Levitt, Malcolm H., P. K. Madhu, and Colan E. Hughes. "Cogwheel Phase Cycling." Journal of Magnetic Resonance 155, no. 2 (April 2002): 300–306. http://dx.doi.org/10.1006/jmre.2002.2520.

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4

Della Grotta, Lynn M., Raymond B. Dyer, and Brenda L. Holbert. "The “cogwheel” sign of hydrosalpinx." Abdominal Radiology 44, no. 10 (July 25, 2019): 3486–87. http://dx.doi.org/10.1007/s00261-019-02144-7.

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5

Hughes, Colan E., Marina Carravetta, and Malcolm H. Levitt. "Some conjectures for cogwheel phase cycling." Journal of Magnetic Resonance 167, no. 2 (April 2004): 259–65. http://dx.doi.org/10.1016/j.jmr.2004.01.001.

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6

Braun, O. M., and Erio Tosatti. "Molecular rolling friction: the cogwheel model." Journal of Physics: Condensed Matter 20, no. 35 (August 11, 2008): 354007. http://dx.doi.org/10.1088/0953-8984/20/35/354007.

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7

Gisbert, Yohan, Seifallah Abid, Gaëlle Bertrand, Nathalie Saffon-Merceron, Claire Kammerer, and Gwénaël Rapenne. "Modular synthesis of pentaarylcyclopentadienyl Ru-based molecular machines via sequential Pd-catalysed cross couplings." Chemical Communications 55, no. 97 (2019): 14689–92. http://dx.doi.org/10.1039/c9cc08384g.

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Abid, Seifallah, Yohan Gisbert, Mitsuru Kojima, Nathalie Saffon-Merceron, Jérôme Cuny, Claire Kammerer, and Gwénaël Rapenne. "Desymmetrised pentaporphyrinic gears mounted on metallo-organic anchors." Chemical Science 12, no. 13 (2021): 4709–21. http://dx.doi.org/10.1039/d0sc06379g.

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9

Jesacher, Alexander, Severin Fr�hapter, Stefan Bernet, and Monika Ritsch-Marte. "Size selective trapping with optical "cogwheel" tweezers." Optics Express 12, no. 17 (2004): 4129. http://dx.doi.org/10.1364/opex.12.004129.

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10

Abrams, A., and D. Braff. "Lithium Induced Cogwheel Rigidity: Treatment with Amantadine." Pharmacopsychiatry 13, no. 04 (March 13, 2008): 240–42. http://dx.doi.org/10.1055/s-2007-1019637.

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Šidiková, Michaela, Radek Martinek, Martina Ládrová, René Jaroš, Petr Bilík, Zdeněk Macháček, Lukas Snajdr, Vlastimil Slaný, and Ján Jobbágy. "Inspection of the Cogwheel Using Virtual Instrumentation." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 67, no. 6 (2019): 1493–501. http://dx.doi.org/10.11118/actaun201967061493.

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This paper deals with use of machine vision for the needs of automated inspections based on virtual instrumentation using a visualization tool named Vision Builder for Automated Inspection (VBAI) – National Instruments (NI). An application for camera tests of dimensions, shapes and presence is designed in experimental parts. This work is focused on the control, detection and distribution properties of internal holes.
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12

Ballesteros, A., B. Cortés, A. Petcu, L. Montes, W. Jaimes, and F. Inchausti. "Atypical antipsychotic switching versus atypical antipsychotic combination in schizoaffective disorder – A clinical case." European Psychiatry 33, S1 (March 2016): S536. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1985.

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IntroductionRecent studies suggest that aripiprazole (ARP) shows a better profile in terms of mental state and extrapyramidal symptoms (EPS) in psychosis. However, other studies consider that a combination of atypical antipsychotics (AAP) may also be an option for some refractory patients. We present a case of a schizoaffective disorder, manic type (SAFM) (F25.0, ICD-10 criteria) that improved in terms of EPS adverse effects after switching from long-term fluphenazine (LTF) to Long-acting injectable aripiprazole (LAIA) but showed relapse symptoms.ObjectiveWe present a clinical case of SAFM that improved clinically in our outpatient clinic after 1 month of bi-therapy with low doses of oral risperidone and standard dose of LAIA. We study oral AAP-LAIA drug combination utility in this clinical setting.AimsTo study “oral AAP-LAIA combo” benefits in refractory SAFM cases.MethodsOur patient is a 68-year-old female diagnosed of SAFM clinically stable with a combination of lithium and LTF. She presented severe cogwheel stiffness in the upper limbs and postural tremor. We switched from long-term fluphenazine to LAIA and 4 weeks later, she showed discrete cogwheel stiffness but also persecutory delusions and dysphoria.ResultsWe maintained LAIA (400 mg/28 days) and lithium (800 mg/day) doses and added-on risperidone 1 mg/day. She presented clinical relapse 1 month later. She kept her better EPS tolerance as she only had discrete cogwheel in upper limbs only by using attention distraction techniques.ConclusionsOral risperidone-LAIA drug combination appears as an effective and well-tolerated treatment in refractory SAFM cases.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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13

Jerschow, Alexej, and Rajeev Kumar. "Calculation of coherence pathway selection and cogwheel cycles." Journal of Magnetic Resonance 160, no. 1 (January 2003): 59–64. http://dx.doi.org/10.1016/s1090-7807(02)00031-9.

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14

Millot, Yannick, Redouane Hajjar, and Pascal P. Man. "Determination of NMR cogwheel phase cycle with XML." Solid State Nuclear Magnetic Resonance 35, no. 4 (July 2009): 223–29. http://dx.doi.org/10.1016/j.ssnmr.2009.01.003.

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15

Gupta, Sudhiranjan. "MiR-29 family: another “cogwheel” in myocardial remodeling." Non-coding RNA Investigation 2 (2018): 11. http://dx.doi.org/10.21037/ncri.2018.02.04.

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16

Xu, Yongbin, Arne Moeller, So-Young Jun, Minho Le, Bo-Young Yoon, Jin-Sik Kim, Kangseok Lee, and Nam-Chul Ha. "Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria." Journal of Biological Chemistry 287, no. 15 (February 3, 2012): 11740–50. http://dx.doi.org/10.1074/jbc.m111.329375.

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Gram-negative bacteria are capable of expelling diverse xenobiotic substances from within the cell by use of three-component efflux pumps in which the energy-activated inner membrane transporter is connected to the outer membrane channel protein via the membrane fusion protein. In this work, we describe the crystal structure of the membrane fusion protein MexA from the Pseudomonas aeruginosa MexAB-OprM pump in the hexameric ring arrangement. Electron microscopy study on the chimeric complex of MexA and the outer membrane protein OprM reveals that MexA makes a tip-to-tip interaction with OprM, which suggests a docking model for MexA and OprM. This docking model agrees well with genetic results and depicts detailed interactions. Opening of the OprM channel is accompanied by the simultaneous exposure of a protein structure resembling a six-bladed cogwheel, which intermeshes with the complementary cogwheel structure in the MexA hexamer. Taken together, we suggest an assembly and channel opening model for the MexAB-OprM pump. This study provides a better understanding of multidrug resistance in Gram-negative bacteria.
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17

Bayer, Jan, and Shota Urushadze. "Cogwheel load: a new forced vibration test for bridges?" Journal of Civil Structural Health Monitoring 12, no. 1 (October 13, 2021): 71–80. http://dx.doi.org/10.1007/s13349-021-00527-3.

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18

Betini, Beatriz Gioppo, Alex Tiburtino Meira, and Hélio Afonso Ghizoni Teive. "Camillo Negro and his contributions to neurology." Arquivos de Neuro-Psiquiatria 77, no. 9 (September 2019): 669–71. http://dx.doi.org/10.1590/0004-282x20190038.

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ABSTRACT An historical review of the contributions made by Italian professor, Camillo Negro, to neurology. Negro published several books on clinical neurology, was one of the pioneers of scientific films and described numerous neurological diseases. He is best known for describing the cogwheel phenomenon in patients with Parkinson's disease but also described a sign of peripheral facial paralysis.
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Bayer, Jan, Shota Urushadze, Jong-Dar Yau, and Yeong-Bin Yang. "Cogwheel loading as a moving test load for bridges – analysis and laboratory experiments." MATEC Web of Conferences 310 (2020): 00030. http://dx.doi.org/10.1051/matecconf/202031000030.

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A moving impulse load generated by a heavy cogwheel can be used as a testing excitation for bridges. This novel type of dynamic load acts along the entire driving path, its intensity is adjustable, and it can be very efficient in the case of resonance. Verification tests were performed on a model under laboratory conditions and compared to numerical simulation. The results are extensively discussed.
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20

Li, Peng, Ming Huang, Jingjing Yang, Qiannan Lu, Baojing Hu, and Meixia Yang. "A Cogwheel WGM Resonator Based on Spoof Surface Plasmon Polaritons." Journal of Computer and Communications 08, no. 12 (2020): 102–12. http://dx.doi.org/10.4236/jcc.2020.812010.

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21

Tamm, Matthias, Bernd Dreβel, and Roland Fröhlich. "Molecular Structure of a Heptadentate Cogwheel: C7Me7+Is Not Planar†." Journal of Organic Chemistry 65, no. 20 (October 2000): 6795–97. http://dx.doi.org/10.1021/jo000958c.

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22

Nagel, N., P. Eller, and H. Bock. "Benzene-1,2-disulfonate dianion: another compound with meshed cogwheel substituents?" Acta Crystallographica Section B Structural Science 52, no. 3 (June 1, 1996): 562–68. http://dx.doi.org/10.1107/s0108768195014170.

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Crystal structures of the dipotassium and potassium tetramethylammonium salts of benzene-1,2-disulfonic acid have been determined at 200 K and a PM3 enthalpy hypersurface for the substituent rotations of the free benzene-1,2-disulfonate dianion was calculated. The cogging of the two sulfonate groups as well as the possible pathways of conformational isomerization are discussed and compared with already investigated molecules containing adjacent threefold substituents.
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23

Hu, Z. J., X. C. Yuan, S. W. Zhu, G. H. Yuan, P. S. Tan, J. Lin, and Q. Wang. "Dynamic surface plasmon patterns generated by reconfigurable “cogwheel-shaped” beams." Applied Physics Letters 93, no. 18 (November 3, 2008): 181102. http://dx.doi.org/10.1063/1.3005636.

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24

Monro, Jean A., John McLaren-Howard, Mussadiq Shah, Peter O. O. Julu, and Basant K. Puri. "Recovery from Cogwheel Rigidity and Akinesia and Improvement in Vibration Sense and Olfactory Perception following Removal of an Epoxy-Oleic Acid DNA Adduct." Case Reports in Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/3512353.

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The epoxy fatty acidcis-12,13-epoxy-oleic acid, which acts as a DNA adduct, may be generated during long-term storage of many seed oils, including those used in cooking, with frying oils and fried foods being a major source in the modern human diet. Removal of this epoxy fatty acid from the locus of theN-formyl peptide receptors was associated with recovery from cogwheel rigidity and akinesia as well as with improvement in vibration sense and olfactory perception.
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25

Partridge, Benjamin E., Li Wang, Dipankar Sahoo, James T. Olsen, Pawaret Leowanawat, Cecilé Roche, Henrique Ferreira, et al. "Sequence-Defined Dendrons Dictate Supramolecular Cogwheel Assembly of Dendronized Perylene Bisimides." Journal of the American Chemical Society 141, no. 40 (September 18, 2019): 15761–66. http://dx.doi.org/10.1021/jacs.9b08714.

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26

Zuckerstätter, Gerhard, and Norbert Müller. "Coherence pathway selection by cogwheel phase cycling in liquid-state NMR." Concepts in Magnetic Resonance Part A 30A, no. 2 (March 2007): 81–99. http://dx.doi.org/10.1002/cmr.a.20079.

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27

Kaleta, Jiří, Josef Michl, Cécile Mézière, Sergey Simonov, Leokadiya Zorina, Pawel Wzietek, Antonio Rodríguez-Fortea, Enric Canadell, and Patrick Batail. "Gearing motion in cogwheel pairs of molecular rotors: weak-coupling limit." CrystEngComm 17, no. 41 (2015): 7829–34. http://dx.doi.org/10.1039/c5ce01372k.

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Investigation of the rotor dynamics by X-ray diffraction, spin–lattice relaxation, and DFT modelling of the two rotational barriers in arrays of rod-like molecules with 1,3-bis(ethynyl)bicyclo[1.1.1]pentane rotators conclude to gearing motion between two rotors in a pair.
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28

Glen Hashmi, Z., and Katrin Muff. "Rethinking Corporate Sustainability Within the Well-Being Context: The COGWHEEL Sustainability Framework." Building Sustainable Legacies: The New Frontier Of Societal Value Co-Creation 2014, no. 2 (January 1, 2014): 67–96. http://dx.doi.org/10.9774/gleaf.8901.2014.ja.00005.

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29

Tamm, Matthias, Bernd Dressel, and Roland Froehlich. "ChemInform Abstract: Molecular Structure of a Heptadentate Cogwheel: C7Me7+ Is Not Planar." ChemInform 32, no. 7 (May 30, 2010): no. http://dx.doi.org/10.1002/chin.200107076.

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30

Kuotsu, Medo M., Arjun Bal Kallupurakkal, Nyamnyei Konyak, Keisham Jaya Chanu, Vikie-o. Khruomo, and Dinesh Kumar Perumal. "A rare case of sporadic Creutzfeldt-Jakob disease in an 83 years old female." International Journal of Advances in Medicine 8, no. 2 (January 27, 2021): 279. http://dx.doi.org/10.18203/2349-3933.ijam20210276.

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Sporadic Creutzfeldt-Jakob disease is a rare invariably fatal neurodegenerative prion disease. Prion disease are associated with the conversion of alpha-helix rich cellular prion protein (PrPC) into a beta-structure rich insoluble conformer scrapie isoform (PrPSc) thought to be infectious isoform. Here we present a case of an 83 years old woman with findings of rapidly progressive dementia, cognitive disturbance, myoclonic jerks and extrapyramidal signs (cogwheel rigidity). Following a series of clinical and diagnostic (diffusion-weighted magnetic resonance imaging (MRI) brain, electroencephalogram (EEG)) examination she was diagnosed with sporadic Creutzfeldt-Jakob disease based on Centers for disease control and prevention (CDC) criteria.
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Zuckerstätter, Gerhard, and Norbert Müller. "Cogwheel phase cycling in common triple resonance NMR experiments for the liquid phase." Journal of Magnetic Resonance 181, no. 2 (August 2006): 244–53. http://dx.doi.org/10.1016/j.jmr.2006.05.004.

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32

Ivchenko, Natala, Colan E. Hughes, and Malcolm H. Levitt. "Application of cogwheel phase cycling to sideband manipulation experiments in solid-state NMR." Journal of Magnetic Resonance 164, no. 2 (October 2003): 286–93. http://dx.doi.org/10.1016/s1090-7807(03)00206-4.

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Kang, Hyun Gu, Myong Chul Park, and Dong Ha Park. "A New Modality for Treating Congenital Melanocytic Nevus: "Cogwheel Pattern" Serial Excision Method." Archives of Plastic Surgery 41, no. 4 (2014): 418. http://dx.doi.org/10.5999/aps.2014.41.4.418.

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Millot, Yannick, Redouane Hajjar, and Pascal P. Man. "NMR cogwheel phase cycling determination with web tools: Amplitude-modulated z-filter MQMAS sequence." Solid State Nuclear Magnetic Resonance 38, no. 1 (July 2010): 19–26. http://dx.doi.org/10.1016/j.ssnmr.2010.06.001.

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35

Yao, Sheldon C. "Effects of Osteopathic Manipulative Treatment on Pulmonary Function in a Parkinson’s Disease Patient." AAO Journal 30, no. 4 (December 1, 2020): 26–30. http://dx.doi.org/10.53702/2375-5717-30.4.26.

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Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with motor symptoms including resting tremor, bradykinesia, cogwheel rigidity, and postural instability. Parkinson’s patients can also exhibit respiratory symptoms. The muscle rigidity associated with PD has been found to be highly correlated with the severity of pulmonary dysfunction. This case details the treatment of a 73-year-old PD patient who presented with acute dyspnea that resolved with application of osteopathic manipulative treatment (OMT). Treatment focused on addressing thoracic cage musculoskeletal restrictions, balancing autonomic flow, and improving circulatory and lymphatic flow. The patient’s respiratory symptoms were alleviated despite a lack of significant pulmonary function test changes immediately post-treatment. This case demonstrates the positive effect of integrating OMT for the treatment of pulmonary symptoms in PD.
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36

Mallat, Chibli. "Mapping Saudi Criminal Law." American Journal of Comparative Law 68, no. 4 (December 1, 2020): 836–92. http://dx.doi.org/10.1093/ajcl/avaa032.

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Abstract This Article maps the criminal law system in Saudi Arabia. Saudi Arabia enacted a criminal procedure code in 2001, but it lacks a comprehensive penal code, relying instead on (i) identifications of certain acts as violations of the law (from public behavior to matters of the state administrative cogwheel) scattered in various pieces of legislation and (ii) the classical Islamic legal tradition’s classification forming a criminal Islamic common law which is organized into (a) “set punishment” prescribed crimes (hadd, plural hudud), (b) crimes left to the court’s discretion (ta‘zir), and (c) two other forms of “violations of the body” with their own legal regime (qisas/retaliation and diya/blood money). The Article is based on extensive case law released by the Saudi Ministry of Justice.
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Wilkes, M. V. "The cogwheel brain: charles babbage and the quest to build the first computer [Book Review]." IEEE Annals of the History of Computing 22, no. 4 (October 2000): 62–63. http://dx.doi.org/10.1109/mahc.2000.887990.

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Tamm, Matthias, Bernd Dreßel, Roland Fröhlich, and Klaus Bergander. "Complexes containing the heptadentate cogwheel C7Me7: synthesis and structural characterization of heptamethylcycloheptatrienyl (CHT*) tungsten complexes." Chemical Communications, no. 18 (2000): 1731–32. http://dx.doi.org/10.1039/b004970k.

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Goulko, Olga, and Adrian Kent. "The grasshopper problem." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 473, no. 2207 (November 2017): 20170494. http://dx.doi.org/10.1098/rspa.2017.0494.

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We introduce and physically motivate the following problem in geometric combinatorics, originally inspired by analysing Bell inequalities. A grasshopper lands at a random point on a planar lawn of area 1. It then jumps once, a fixed distance d , in a random direction. What shape should the lawn be to maximize the chance that the grasshopper remains on the lawn after jumping? We show that, perhaps surprisingly, a disc-shaped lawn is not optimal for any d >0. We investigate further by introducing a spin model whose ground state corresponds to the solution of a discrete version of the grasshopper problem. Simulated annealing and parallel tempering searches are consistent with the hypothesis that, for d < π −1/2 , the optimal lawn resembles a cogwheel with n cogs, where the integer n is close to π ( arcsin ⁡ ( π d / 2 ) ) − 1 . We find transitions to other shapes for d ≳ π − 1 / 2 .
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Bednyi, I. A. "Method for the identification of mode shapes for a cogwheel according to readings of one vibration detector." Journal of Machinery Manufacture and Reliability 42, no. 1 (January 2013): 54–57. http://dx.doi.org/10.3103/s1052618813010032.

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Bastien, Guillaume, Cyprien Lemouchi, Magali Allain, Pawel Wzietek, Antonio Rodríguez-Fortea, Enric Canadell, Konstantinos Iliopoulos, Denis Gindre, Michael Chrysos, and Patrick Batail. "Changing gears to neutral in a polymorph of one-dimensional arrays of cogwheel-like pairs of molecular rotors." CrystEngComm 16, no. 7 (2014): 1241. http://dx.doi.org/10.1039/c3ce42054j.

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Marinova, Desislava, and Maya Danovska. "THE MOTOR SYMPTOMS–CHALLENGE IN DIAGNOSIS OF PARKINSON'S DISEASE." Journal of IMAB - Annual Proceeding (Scientific Papers) 26, no. 4 (November 24, 2020): 3469–74. http://dx.doi.org/10.5272/jimab.2020264.3469.

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Parkinson's disease (PD) is the second most common neurodegenerative disorder after the dementia of Alzheimer. The clinical presentation of PD is dominated by typical motor symptoms as resting tremor, cogwheel rigidity, bradykinesia, and postural instability. Non-motor symptoms (NMS) of Parkinson's disease are common but are often under-recognized in clinical practice either due to the lack of spontaneous complaints by the patients or to the absence of systematic questioning by healthcare professionals. In contrast to motor dysfunctions, non-motor symptoms frequently remain unreported. Recently, a self-completed NMS questionnaire and NMS scale for identification and evaluation of these symptoms have been validated. An international survey has shown that up to 62% of NMS in PD remain undeclared to healthcare professionals because patients are unaware that NMS symptoms are linked to PD. Based on both clinical and neuropathological data, PD, traditionally accepted as a dopaminergic motor disorder, now can be characterized as a multisystem neurodegenerative disease that involves many neurotransmitter systems and affects not only motor but non-motor functions, too.
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Kohen, Izchak, Marc L. Gordon, and Peter Manu. "Serotonin Syndrome in Elderly Patients Treated for Psychotic Depression with Atypical Antipsychotics and Antidepressants: Two Case Reports." CNS Spectrums 12, no. 8 (August 2007): 596–98. http://dx.doi.org/10.1017/s1092852900021386.

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ABSTRACTWe report two cases of serotonin syndrome in elderly patients during treatment of psychotic depression with atypical antipsychotics and antidepressants. The first case is a 69-year-old man who was admitted for depression with psychosis and treated with trazodone, risperidone, and sertraline. Subsequently, he developed myoclonus, tremor, cogwheel rigidity, and diaphoresis. The second case is a 72-year-old female initially admitted to a medical inpatient unit for a change in mental status that presented as increased confusion, lethargy, slurred speech, and a fever of 101.5°. She had been on phenelzine and quetiapine. In both cases, all symptoms resolved within 24 hours of the psychotropics being stopped. In both cases, we believe that serotonin syndrome was produced by a combination of an antidepressant and an atypical antipsychotic. There have been several case reports of serotonin syndrome from similar combinations of antidepressant and atypical antipsychotic treatment. Clinicians treating elderly patients with a combination of serotonergic antidepressants and atypical antipsychotics for psychotic depression should be aware of the potential for serotonin syndrome.
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Peres, João, Simão Cruz, Rita Oliveira, Luís Santos, and Ana Valverde. "A Case Report of Nonvasculitic Autoimmune Inflammatory Meningoencephalitis with Sensory Ganglionopathy: A Rare Presentation of Sjögren Syndrome." Case Reports in Neurological Medicine 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/5696512.

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A 68-year-old Caucasian female was admitted to the emergency department with a progressive history of behavioural symptoms and anxiety followed by visual and auditory hallucinations, forgetfulness, and impaired gait in the previous 3 months. On examination she was psychotic and had a postural and rest tremor of the upper limbs, cogwheel rigidity of the four limbs, retropulsion on standing position, and inability to walk. During the following 2 weeks she developed xerostomia and unilateral parotiditis that improved with steroids. A simultaneous improvement of the cognitive abilities allowed for the detection of sensory ataxia of the lower limbs. Sensory ganglionopathy was then detected with electrophysiological studies. A diagnosis of Sjögren syndrome was suspected and confirmed by salivary gland scintigraphy, Schirmer’s test, and submaxillary gland biopsy. We report a case of Sjögren syndrome associated with central and peripheral nervous system involvement, without sicca symptoms preceding the neurological clinical picture. The coexistence of ganglionopathy and a favourable response to immunosuppression are key features that can lead to the correct diagnosis in cases with atypical CNS symptoms, mimicking a rapidly progressive dementia.
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Hernández, José L., Francisco J. Ramos, Jon Infante, Mariano Rebollo, and Jesús González-Macías. "Severe Serotonin Syndrome Induced by Mirtazapine Monotherapy." Annals of Pharmacotherapy 36, no. 4 (April 2002): 641–43. http://dx.doi.org/10.1345/aph.1a302.

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OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction. CASE SUMMARY: A 75-year-old man developed agitation, confusion, incoordination, and gait disturbance because of progressive rigidity. Mirtazapine had been started 8 days earlier to control major depression. Physical examination revealed diaphoresis, low-grade fever, hypertension, tachycardia, bilateral cogwheel rigidity, hyperreflexia, tremor, and myoclonus, symptoms and signs that are consistent with severe SS. DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed. The possible pathogenic mechanisms leading to this adverse reaction in this patient are also discussed, and pathophysiologic hypotheses are formulated. CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions. In these patients, it might be more adequate to start mirtazapine therapy at a lower dose (<15 mg/d).
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Fogg, G. E. "Book reviews." Notes and Records of the Royal Society of London 55, no. 2 (May 22, 2001): 331–46. http://dx.doi.org/10.1098/rsnr.2001.0148.

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Nine book reviews in the May 2002 issue of Notes and Records : Voyages of discovery: three centuries of natural history exploration , by T. Rice, reviewed by G. E. Fogg. Charles Darwin's Zoology Notes & specimen lists from H.M.S. Beagle , R. Keynes (ed.), reviewed by P. R. Grant. Enlightenment: Britain and the creation of the modern world , by R. Porter, reviewed by P. Fara. Ice blink: the tragic fate of Sir John Franklin's lost polar expedition , by S. Cookman, reviewed by G. F. Hattersley-Smith. The cogwheel brain: Charles Babbage and the quest to build the first computer , by D. Swade, reviewed by M. Campbell-Kelly. The symbolic species: the co-evolution of language and the human brain , by T. Deacon, reviewed by T. Briscoe. Defining features: scientific and medical portraits, 1660-2000 , by L. Jordanova, reviewed by J. Rowlinson. Against the tide: an autobiographical account of a professional outsider , by L. C. Woods, reviewed by J. T. Stuart. A passion for DNA , by J. D. Watson, reviewed by J. Postgate.
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47

Wang, Li, Benjamin E. Partridge, Ning Huang, James T. Olsen, Dipankar Sahoo, Xiangbing Zeng, Goran Ungar, Robert Graf, Hans W. Spiess, and Virgil Percec. "Extraordinary Acceleration of Cogwheel Helical Self-Organization of Dendronized Perylene Bisimides by the Dendron Sequence Encoding Their Tertiary Structure." Journal of the American Chemical Society 142, no. 20 (April 28, 2020): 9525–36. http://dx.doi.org/10.1021/jacs.0c03353.

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48

Patel, M., S. Mohyuddin, and A. Hirsch. "P.115 Association of phantogeusia with Parkinson Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (June 2018): S46. http://dx.doi.org/10.1017/cjn.2018.217.

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Background: Phantogeusia associated with Parkinson Disease has not heretofore been reported. Methods: A 59 year old right handed female presented with a four year history of a bitter, sour and sweet taste on her entire tongue and roof of her mouth, 8/10 intensity, constant, persistent, without any external stimuli. Drinking water tasted bitter and sour. The phantogeusia was unresponsive to dietary changes, gabapentine, and allergy medications. Results: Abnormalities in Neurological examination: Decreased blink frequency. Hypokinetic. Hypomimetic face. Mood appears sad. Cranial Nerve (CN) examination: CN lll, lV, Vl: Saccadization of horizontal eye movements. Motor Examination: Pill rolling tremor in right hand. 1+ cogwheel rigidity in left upper extremity. Gait: 2+ retropulsion. Chemosensory testing: Olfactory: Alcohol Sniff Test: 6 (anosmia). SNAP Phenylethyl Alcohol Threshold Testing left -2.5 (hyposmia) & right > -2.0 (anosmia). Gustatory testing: Propylthiouracil Disc Taste test: 10 (normogeusia). Taste Testing Threshold: normogeusia to NaCl, Sucrose, HCl, Urea, and PTC. Other: DOPAPET: positive for Parkinson disease. Upper endoscopy: normal. Conclusions: Investigation for the presence of parkinsonian features in those with phantogeusia is warranted and chemosensory dysfunction including phantogeusia in those who presents with Parkinson’s disease is worthy of exploration.
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Jeong, Hyeongseop, Jin-Sik Kim, Saemee Song, Hideki Shigematsu, Takeshi Yokoyama, Jaekyung Hyun, and Nam-Chul Ha. "Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC." Structure 24, no. 2 (February 2016): 272–76. http://dx.doi.org/10.1016/j.str.2015.12.007.

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Bräuniger, Thomas, Kevin J. Pike, Robin K. Harris, and P. K. Madhu. "Efficient 5QMAS NMR of spin-5/2 nuclei: use of fast amplitude-modulated radio-frequency pulses and cogwheel phase cycling." Journal of Magnetic Resonance 163, no. 1 (July 2003): 64–72. http://dx.doi.org/10.1016/s1090-7807(03)00124-1.

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