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Journal articles on the topic 'Colchicum autumnale'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Jung, Linda S., Silvia Winter, R. Lutz Eckstein, Monika Kriechbaum, Gerhard Karrer, Erik Welk, Martin Elsässer, Tobias W. Donath, and Annette Otte. "Colchicum autumnale L." Perspectives in Plant Ecology, Evolution and Systematics 13, no. 3 (September 2011): 227–44. http://dx.doi.org/10.1016/j.ppees.2011.04.001.

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2

Нотов, Александр Александрович, Валерий Александрович Нотов, Людмила Владимировна Петухова, Светлана Алексеевна Иванова, and Елена Александровна Андреева. "About polemohoral populations of Colchicum autumnale." Herald of Tver State University. Series: Biology and Ecology, no. 4(60) (December 25, 2020): 95–105. http://dx.doi.org/10.26456/vtbio175.

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В Тверской области обнаружены полемохорные популяции Colchicum autumnale L. Охарактеризована специфика местообитаний вида. Рассмотрены особенности его биологии и экологии. We found polemochoral populations of Colchicum autumnale L. in the Tver Region. We describe specific habitats along with the features of the biology and ecology of the mentioned species.

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3

Lee, Christina. "Ode to Colchicum autumnale." Prairie Schooner 93, no. 2 (2019): 188. http://dx.doi.org/10.1353/psg.2019.0098.

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4

Tsoucalas, Gregory, Theodoros Papaioannou, George Panayiotakopoulos, Zenia Saridaki, Dimitrios A. Vrachatis, and Marianna Karamanou. "Colchicum Genus in the Writings of Ancient Greek and Byzantine Physicians." Current Pharmaceutical Design 24, no. 6 (May 10, 2018): 648–53. http://dx.doi.org/10.2174/1381612824666180115111546.

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The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The first plant was most probably named "Medea" from the notorious Colchican witch. As the most common member of the family blossoms in autumn, the plant was named Colchicum autumnale. Various nominations were also used, such as Ephemeron, Hermodactyl, Anima articulorum and Surugen. Our article discusses them, while at the same time presents the most notable authorities who have used Colchicum plants in herbal medicine and toxicology.

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5

YOSHIDA, Keiichiro, Takahisa HAYASHI, and Konosuke SANO. "Colchicoside in Colchicum autumnale bulbs." Agricultural and Biological Chemistry 52, no. 2 (1988): 593–94. http://dx.doi.org/10.1271/bbb1961.52.593.

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6

Charra, B., A. Hachimi, H. Arsalane, A. Benslama, and S. Motaouakkil. "Intoxication au Colchicum autumnale L." Annales Françaises d'Anesthésie et de Réanimation 26, no. 12 (December 2007): 1081–82. http://dx.doi.org/10.1016/j.annfar.2007.09.022.

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7

Nagesh, K. R., Ritesh G. Menezes, Prateek Rastogi, N. R. Naik, Jitesh Marian Rasquinha, S. Senthilkumaran, and Abul Fazil. "Suicidal plant poisoning with Colchicum autumnale." Journal of Forensic and Legal Medicine 18, no. 6 (August 2011): 285–87. http://dx.doi.org/10.1016/j.jflm.2011.04.008.

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8

Reinalda, B. "G. Harmsen, Herfsttijloos (Colchicum autumnale). Een levensverhaal." BMGN - Low Countries Historical Review 110, no. 3 (January 1, 1995): 393. http://dx.doi.org/10.18352/bmgn-lchr.4060.

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9

Poutaraud and P. Girardin, A. "Agronomical and chemical variability of Colchicum autumnale accessions." Canadian Journal of Plant Science 86, no. 2 (May 5, 2006): 547–55. http://dx.doi.org/10.4141/p04-138.

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Meadow saffron (Colchicum autumnale) is an undomesticated plant from whose seeds the alkaloids colchicine and colchicoside are extracted and used pharmaceutically. Research was conducted towards domesticating meadow saffron in which inter- and intra-genetic variability of accessions was studied. Colchicine, 3-demethylcolchicine and colchicoside were assayed in plants of six accessions collected from natural sites in eastern France. These were cultivated at two sites and studied during 1 or 2 yr. Plants from 70 initial transplanted corms of one accession were studied individually for 4 yr to determined intra-accession variability and, as spontaneous vegetative multiplication of corms occurred, comparisons among plants from one initial transplanted corm were also made. For the main characteristics, seed dry weight (SDW) per plant, alkaloid content and colchicine:colchicoside ratio, the inter-accession variability was lower than the intra-accession variability. The results suggest that vegetative propagation of selected genotypes could improve alkaloid content by about 80% and improve SDW per plant by about 300%. Key words: Colchicine, colchicoside, Colchicum autumnale, medicinal plant, genetic variability

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10

Boonen, A. "Colchicum autumnale from Het Cruydtboeck by Rembertus Dodonaeus." Annals of the Rheumatic Diseases 61, no. 6 (June 1, 2002): 492. http://dx.doi.org/10.1136/ard.61.6.492.

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11

Hayashi, Takahisa, Keiichiro Yoshida, and Konosuke Sano. "Formation of alkaloids in suspension-cultured Colchicum autumnale." Phytochemistry 27, no. 5 (January 1988): 1371–74. http://dx.doi.org/10.1016/0031-9422(88)80196-1.

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12

Brvar, Miran, Gordana Koželj, Martin Možina, and Matjaž Bunc. "Acute poisoning with autumn crocus (Colchicum autumnale L.)." Wiener Klinische Wochenschrift 116, no. 5-6 (March 2004): 205–8. http://dx.doi.org/10.1007/bf03040489.

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13

Karamanou, Marianna, Gregory Tsoucalas, Konstantinos Pantos, and George Androutsos. "Isolating Colchicine in 19th Century: An Old Drug Revisited." Current Pharmaceutical Design 24, no. 6 (May 10, 2018): 654–58. http://dx.doi.org/10.2174/1381612824666180115105850.

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Colchicine is a tricyclic alkaloid extracted from the herbaceous plant Colchicum autumnale. Known since antiquity for its therapeutic efficacy in the treatment of gout, colchicine was reintroduced in 19th century pharmacopeia, thanks to the work of the French chemists and pharmacists Pierre-Joseph Pelletier (1788-1842) and Joseph Bienaimé Caventou (1795-1877) who in 1819, isolated a peculiar substance in the roots of Colchicum autumnale. In 1833, the substance was further analyzed by the German pharmacist and chemist Philipp Lorenz Geiger (1785-1836), who coined the name colchicine. In 1884, the French pharmacist Alfred Houde (1854-1919) produced for the first time pure crystallized colchicine in granules of 1milligram which is still sold under this trade name in several countries. In the last two centuries, colchicine's indications were furthermore expanded. From anti-gout drug during antiquity and a diuretic in 19th century, colchicine is currently administered in several affections such as Adamantiades-Behcet's disease, familial Mediterranean fever, pericarditis and atrial fibrillation.

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14

Ahmedov, E. T., and S. A. Turdiev. "FEATURES OF CULTIVATION OF AUTUMN AUTUMN (COLCHICUM AUTUMNALE L.) IN TASHKENT CONDITIONS." EurasianUnionScientists 3, no. 70 (2020): 21–26. http://dx.doi.org/10.31618/esu.2413-9335.2020.3.70.544.

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15

Wichert, B., S. Aboling, E. Kienzle, T. Bartels, J. Kamphues, and P. Wolf. "Herbstzeitlose ( Colchicum autumnale ) – Vorkommen und mögliche Effekte bei Pferden." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 37, no. 05 (2009): 330–36. http://dx.doi.org/10.1055/s-0038-1623822.

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16

Kritikos, Antonios, and Olivier Spertini. "Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale." Blood 130, no. 1 (July 6, 2017): 95. http://dx.doi.org/10.1182/blood-2017-02-766410.

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17

Гнєзділова, В. І., В. І. Буняк, О. С. Неспляк, and Л. Й. Маховська. "ОСЕРЕДКИ РІДКІСНИХ ВИДІВ В ЛУЧНО-ПАСОВИЩНИХ ТА ЛІСОВИХ ОСЕ-ЛИЩАХ ГОРИ ГВІЗД (СКИБОВІ ГОРГАНИ)." Вісті Біосферного заповідника «Асканія-Нова», no. 21 (April 14, 2021): 393–95. http://dx.doi.org/10.53904/1682-2374/2019-21/57.

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В статті подано характеристику ценопопуляцій рідкісних видів: Colchicum autumnale L., Gladiolus imbricatus L., Dactylorhiza majalis (Reichenb.) P. F. Hunt et Summerhayes, D. sambucina (L.) Soо, Platanthera bifolia (L.) Rich., Gymnadenia conopsea (L.) R. Br., Listera ovata (L.) R. Вr., які зростають на лучних схилах гори Гвізд – на межі Богород-чанського та Надвірнянського районів Івано-Франківської області.

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18

Petrich, Lukas, Georg Lohrmann, Matthias Neumann, Fabio Martin, Andreas Frey, Albert Stoll, and Volker Schmidt. "Detection of Colchicum autumnale in drone images, using a machine-learning approach." Precision Agriculture 21, no. 6 (May 6, 2020): 1291–303. http://dx.doi.org/10.1007/s11119-020-09721-7.

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Abstract Colchicum autumnale are toxic autumn-blooming flowering plants, which often grow on extensive meadows and pastures. Thus, they pose a threat to farm animals especially in hay and silage. Intensive grassland management or the use of herbicides could reduce these weeds but environment protection requirements often prohibit these measures. For this reason, a non-chemical site- or plant-specific weed control is sought, which aims only at a small area around the C. autumnale and with low impact on the surrounding flora and fauna. For this purpose, however, the exact locations of the plants must be known. In the present paper, a procedure to locate blooming C. autumnale in high-resolution drone images in the visible light range is presented. This approach relies on convolutional neural networks to detect the flower positions. The training data, which is based on hand-labeled images, is further enhanced through image augmentation. The quality of the detection was evaluated in particular for grassland sites which were not included in the training to get an estimate for how well the detector works on previously unseen sites. In this case, 88.6% of the flowers in the test dataset were detected, which makes it suitable, e.g., for applications where the training is performed by the manufacturer of an automatic treatment tool and where the practitioners apply it to their previously unseen grassland sites.

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19

Thakur, Shifali, Gitika Chaudhary, and Hemlata Kaurav. "Colchicum autumnale (suranjan): A cytotoxic plant with anti-arthritis properties." Advance Pharmaceutical Journal 6, no. 3 (August 2021): 80–86. http://dx.doi.org/10.31024/apj.2021.6.3.4.

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20

Eve, T., L. Nief, S. Gonçalves, C. Fontfreyde, and S. Jurjanz. "Intake of different hays with presence of Colchicum autumnale by rabbits." World Rabbit Science 25, no. 1 (March 30, 2017): 51. http://dx.doi.org/10.4995/wrs.2017.6486.

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<p>The ingestion of 3 hay types by growing rabbits and the consequences on animal performance were studied in a first part. Two kinds of hay from high nature value grasslands [CFP (<em>Colchico-Festucetum pratensis</em>) and SBR (<em>Senecioni-Brometum racemosi</em>)] differentiated by their botanical composition were compared to a classical agricultural hay (control). The 3 hays, offered <em>ad libitum</em>, were ingested at 30.6, 34.8 and 36.1 g/kg body weight (BW) respectively for SBR, CFP and the control, where the consumption of SBR hay was significantly lower. (P<0.01). The type of hay distributed did not affect the consumption of commercial feed or growth (44 g/kg BW and 36 g/d, respectively). The effect of meadow saffron concentration (<em>Colchicum autumnale</em>) in CFP hay was tested at 3 doses (absence, 2.75 and 15% of the distributed hay mass) with respect to their effect on ingestion and animal health. Again, no effect of the presence of meadow saffron (MeS) in the hay on these parameters was observed, even at the highest dose. However, during this second part, rabbits preferred to consume meadow saffron instead of the rest of the distributed hay (hardly any MeS was refused by rabbits at the representative dose, whereas 12% of the rest of the hay was refused, and 3.4 and 20% respectively at the maximal dose). The intake of the toxic alkaloid colchicine corresponded to 30 to 44% of the median lethal doses (LD<sub>50</sub>) at the representative and maximal doses respectively. The real exposure of the rabbits was probably lower, as the absorption of ingested colchicine is reported to be around 50% of the LD<sub>50</sub> values which are established after an intravenous injection. Nevertheless, the absence of any effect should be interpreted with caution. The colchicine content of MeS varied greatly depending on the time of harvest and the parts of the plant taken into consideration. A late harvest (mid-June or later) would ensure (very) low concentrations of colchicine in the aerial parts of MeS. The presence of cloves on this plant should be completely avoided, due to the very high concentration of colchicine in the seeds. Moreover, long term exposure of the animals to this toxic plant may increase the risk of adverse effects. The study shows that hay distribution can aid digestion without altering the animal’s performance. Moreover, the valorisation of hay from high nature value grasslands would not only add real value to the commercialisation of rabbit meat by commercial breeders, but also to pet owners on the condition that hay quality would be guaranteed.</p>

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21

Ellington, E., T. Adserias, A. Coma, J. Bastida, F. Viladomat, and C. Codina. "EFFECT OF PACLOBUTRAZOL ON IN VITRO CULTURE OF COLCHICUM AUTUMNALE CORMS." Acta Horticulturae, no. 447 (October 1997): 131–34. http://dx.doi.org/10.17660/actahortic.1997.447.18.

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22

Nasreen, Amber, Heidrun Gundlach, and Meinhart H. Zenk. "Incorporation of phenethylisoquinolines into colchicine in isolated seeds of Colchicum autumnale." Phytochemistry 46, no. 1 (September 1997): 107–15. http://dx.doi.org/10.1016/s0031-9422(97)00242-2.

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23

Frankova, L., H. Komjathyova, K. Boka, O. Gasparikova, and M. Psenak. "Biochemical and Physiological Aspects of Developmental Cycle of Colchicum autumnale L." Biologia plantarum 46, no. 4 (December 1, 2003): 509–16. http://dx.doi.org/10.1023/b:biop.0000041054.71761.0b.

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24

Sannohe, S., Y. Makino, T. Kita, N. Kuroda, and T. Shinozuka. "Colchicine Poisoning Resulting from Accidental Ingestion of Meadow Saffron (Colchicum Autumnale)." Journal of Forensic Sciences 47, no. 6 (November 1, 2002): 15581J. http://dx.doi.org/10.1520/jfs15581j.

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25

Wierdak, Szymon. "O zielonokwiatowym zimowicie [Colchicum autumnale L. var. vernum Rchb. lusus viridiflorum Kruber]." Acta Societatis Botanicorum Poloniae 2, no. 4 (2017): 265–68. http://dx.doi.org/10.5586/asbp.1924.019.

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26

Kobayashi, Masakazu, Yuta Yokokawa, Koji Hara, Noriko Miyagawa, Motoo Fujita, Ryosuke Nomura, Takeaki Sato, and Shigeki Kushimoto. "Colchicine poisoning due to accidental ingestion of Colchicum autumnale: a case report." Nihon Shuchu Chiryo Igakukai zasshi 25, no. 1 (2018): 47–48. http://dx.doi.org/10.3918/jsicm.25_47.

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27

Yoshida, Keiichiro, Takahisa Hayashi, and Konosuke Sano. "Colchicine precursors and the formation of alkaloids in suspension-cultured Colchicum autumnale." Phytochemistry 27, no. 5 (January 1988): 1375–78. http://dx.doi.org/10.1016/0031-9422(88)80197-3.

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28

Hermanns-Clausen, M., H. Schumacher, L. Jahn, and U. Stedtler. "Letale Vergiftung nach Verwechslung von Krokus (Crocus species) mit Herbstzeitloser (Colchicum autumnale)." Intensivmedizin und Notfallmedizin 44, no. 2 (March 2007): 104–9. http://dx.doi.org/10.1007/s00390-006-0708-z.

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29

Rieder-Komorek, Bernd. "Zur Geschichte des Rheumabegriffs und der naturheilkundlichen Therapie rheumatischer Erkrankungen." Arthritis und Rheuma 24, no. 02 (2004): 37–42. http://dx.doi.org/10.1055/s-0037-1618452.

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ZusammenfassungDer Rheumabegriff als einer der ältesten Begriffe im Bereich des wissenschaftlichen Sprachgebrauchs muss aus seinem geschichtlichen Werdegang heraus verstanden werden. Hippokrates schuf einen auf humoralpathologischen Vorstellungen beruhenden Rheumabegriff. Ein zentraler Punkt der Therapie rheumatischer Erkrankungen war die Balneotherapie, wie sie in zahlreichen Thermen des klassischen Altertums stattfand. Auch ausleitende Verfahren wie Aderlass, Schröpfen und Blutegelapplikationen werden seit 2500 Jahren durchgeführt. Zu den ältesten Heilmethoden der Menschheitsgeschichte gehört das Heilfasten und das kultische oder religiöse Fasten. In der Phytotherapie ist die Herbstzeitlose (Colchicum autumnale) eines der ältesten spezifischen beim Rheumatismus eingesetzten Arzneimittel.

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30

Thakkar, Shalini, Santosh Wanjale, and Prasad Panzade. "ECO-FRIENDLY PHYTO-SYNTHESIS OF SILVER NANOPARTICLES USING COLCHICUM AUTUMNALE AND ITS CHARACTERIZATION." International Journal of Advanced Research 4, no. 6 (June 30, 2016): 1903–15. http://dx.doi.org/10.21474/ijar01/788.

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31

Terai, Akiko, Kayo Hagino, Hiroyuki Asakura, Mami Ogai, Midori Yanagihara, Keisuke Kimura, Tomoya Tanaka, et al. "A Rapid and Simple Method for Detection of Colchicum autumnale Using PCR." Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 59, no. 4 (August 25, 2018): 174–82. http://dx.doi.org/10.3358/shokueishi.59.174.

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32

Klintschar, Michael, Christine Beham-Schmidt, Herbert Radner, Gerald Henning, and Peter Roll. "Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects." Forensic Science International 106, no. 3 (December 1999): 191–200. http://dx.doi.org/10.1016/s0379-0738(99)00191-7.

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33

Czerwonka, Dominika, Szymon Sobczak, Ewa Maj, Joanna Wietrzyk, Andrzej Katrusiak, and Adam Huczyński. "Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine." Molecules 25, no. 5 (March 5, 2020): 1180. http://dx.doi.org/10.3390/molecules25051180.

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Colchicine, a pseudoalkaloid isolated from Colchicum autumnale, has been identified as a potent anticancer agent because of its strong antimitotic activity. It was shown that colchicine modifications by regioselective demethylation affected its biological properties. For demethylated colchicine analogs, 10-demethylcolchicine (colchiceine, 1) and 1-demethylthiocolchicine (3), a series of 12 colchicine derivatives including 5 novel esters (2b–c and 4b–d) and 4 carbonates (2e–f and 4e–f) were synthesized. The antiproliferative activity assay, together with in silico evaluation of physicochemical properties, confirmed attractive biological profiles for all obtained compounds. The substitutions of H-donor and H-acceptor sites at C1 in thiocolchicine position provide an efficient control of the hydration affinity and solubility, as demonstrated for anhydrate 3, hemihydrate 4e and monohydrate 4a.

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34

Ellington, Ernesto, Jaume Bastida, Francesc Viladomat, and Carles Codina. "Supercritical carbon dioxide extraction of colchicine and related alkaloids from seeds of Colchicum autumnale L." Phytochemical Analysis 14, no. 3 (2003): 164–69. http://dx.doi.org/10.1002/pca.702.

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35

Poutaraud, Anne, and Philippe Girardin. "Influence of chemical characteristics of soil on mineral and alkaloid seed contents of Colchicum autumnale." Environmental and Experimental Botany 54, no. 2 (September 2005): 101–8. http://dx.doi.org/10.1016/j.envexpbot.2004.06.007.

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36

Spasevska, Ivana, Ahmed Ayoub, Philip Winter, Jordane Preto, Gane Wong, Charles Dumontet, and Jack Tuszynski. "Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin." International Journal of Molecular Sciences 18, no. 8 (August 2, 2017): 1676. http://dx.doi.org/10.3390/ijms18081676.

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37

Scheffer, C., M. Kroetz, M. Debus, C. Heckmann, and M. Girke. "Colchicum autumnale in the treatment of patients with subclinical hyperthyroidism: Results of a prospective pilot study." European Journal of Integrative Medicine 1, no. 4 (December 2009): 199–200. http://dx.doi.org/10.1016/j.eujim.2009.08.107.

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38

YAMADA, Manabu, Michio NAKAGAWA, Makoto HARITANI, Masaru KOBAYASHI, Hidefumi FURUOKA, and Takane MATSUI. "Histopathological Study of Experimental Acute Poisoning of Cattle by Autumn Crocus (Colchicum autumnale L.)." Journal of Veterinary Medical Science 60, no. 8 (1998): 949–52. http://dx.doi.org/10.1292/jvms.60.949.

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39

YAMADA, Manabu, Takane MATSUI, Yoshiyasu KOBAYASHI, Hidefumi FURUOKA, Makoto HARITANI, Masaru KOBAYASHI, and Michio NAKAGAWA. "Supplementary Report on Experimental Autumn Crocus (Colchicum autumnale L.) Poisoning in Cattle: Morphological Evidence of Apoptosis." Journal of Veterinary Medical Science 61, no. 7 (1999): 823–25. http://dx.doi.org/10.1292/jvms.61.823.

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40

Pradana, Dovy Andis, and Sri Hartatik. "PENGARUH KOLKISIN TERHADAP KARAKTER MORFOLOGI TANAMAN TERUNG (Solanum melongena L.)." Berkala Ilmiah Pertanian 2, no. 4 (November 7, 2019): 155. http://dx.doi.org/10.19184/bip.v2i4.16314.

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ABSTRACT The Eggplant (Solanum melongena L.) is one of the plant commodities that has high economic value. Eggplant production is still volatile so plant breeding with a colchicine mutation is needed to increase eggplant production. Colchicine is Colchicum autumnale seed extract which is able to weaken the spindle thread from the metaphase process to anaphase so that chromosome multiplication occurs without the formation of cell walls. Eggplant sprouts induced by different concentrations of colchicine, they are 0 ppm (K0), 100 ppm (K1), 200 ppm (K2) for 6 hours (L1), 12 hours (L2), 18 hours (L3) . The variables observed were morphological characters such as plant height, flowering age, fruit weight, fruit diameter, fruit length, leaf length, leaf width and stem diameter. The results of the treatment show concentration of colchicine and soaking time had a very significant effect on fruit diameter and fruit weight. K1L2 is the most effectif treatment on diameter and weigh of fruit.The concentration of colchicine has a significant effect on plant height and flowering age. The most effectif concentration in plant height and flowering age is K1. Keywords: Eggplant, Colchicine concentration, Soaking time of colchicine ABSTRAK Terung (Solanum melongena L.) merupakan salah satu komoditas tanaman dengan nilai ekonomis tinggi. Produksi terung masih fluktuatif sehingga pemuliaan tanaman dengan mutasi colchicine diperlukan untuk meningkatkan produksi terung. Colchicine merupakan ekstrak dari biji Colchicum autumnale yang mampu melemahkan untaian DNA dari proses metafase menjadi anafase, sehingga multiplikasi kromosom terjadi tanpa pembentukan dinding sel. Kecambah terung diinduksi dengan colchicine dalam konsentrasi yang berbeda, yaitu 0 ppm (K0), 100 ppm (K1), 200 ppm (K2) selama 6 jam (L1), 12 jam (L2), 18 jam (L3). Variabel yang diamati adalah karakter morfologi seperti tinggi tanaman, umur berbunga, berat buah, diameter buah, panjang buah, panjang daun, lebar daun dan diameter batang. Hasil percobaan menunjukkan konsentrasi colchicine dan waktu perendaman memiliki pengaruh yang sangat signifikan terhadap diameter buah dan berat buah. Perlakuan K1L2 merupakan perlakuan yang paling efektif mempengaruhi diameter dan berat buah. Konsentrasi colchicine memiliki efek signifikan terhadap tinggi tanaman dan usia berbunga. Konsentrasi paling efektif terhadap tinggi tanaman dan umur berbunga adalah K1. Kata Kunci: Terung, konsentrasi colchicine, waktu perendaman colchicine

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Poutaraud and P. Girardin, A. "Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation." Canadian Journal of Plant Science 83, no. 1 (January 1, 2003): 23–29. http://dx.doi.org/10.4141/p01-201.

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Alkaloids extracted from meadow saffron seeds are used in numerous medicines. To test the influence of cultivation and climatic conditions on the production and the quality of meadow saffron seeds, we studied seed alkaloid yield on a natural site (grassland) and in a cultivated crop over several years. Seeds contained in capsules harvested before their dehiscence were dried and ground. The alkaloids of the extracts (colchicoside, demethylcolchicine and colchicine) were analyzed by high-pressure liquid chromatography. Seed alkaloid content was not influenced by year, inter-plant competition, or number of capsules per plant. Seed dry matter yield per plant, however, practically tripled in the cultivated crop due to an increase in the number of capsules per plant compared to the grassland. In the cultivated crop, 47% of fruiting plants produced two new plants (corms) every year. Four years after planting, this vegetative multiplication resulted in intraspecific competition, inducing a decline in seed yield per plant linked to a decrease in the weight of seeds per capsule. We were able to show that cultivated production of meadow saffron greatly increased dry matter and alkaloid yield per plant and per hectare, but that it could lead to the need to thin after several years. Key words: meadow saffron, alkaloids, colchicine, cultivation

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Winter, Silvia, Marianne Penker, and Monika Kriechbaum. "Integrating farmers’ knowledge on toxic plants and grassland management: a case study on Colchicum autumnale in Austria." Biodiversity and Conservation 20, no. 8 (May 3, 2011): 1763–87. http://dx.doi.org/10.1007/s10531-011-0060-x.

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Adriaens, Dries, Hans Jacquemyn, Olivier Honnay, and Martin Hermy. "Conservation of remnant populations of Colchicum autumnale – The relative importance of local habitat quality and habitat fragmentation." Acta Oecologica 35, no. 1 (January 2009): 69–82. http://dx.doi.org/10.1016/j.actao.2008.08.003.

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Angelidis, Christos, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharoulis, Fotios Kolokathis, Vasilios Kekeris, and Georgios Giannopoulos. "Colchicine Pharmacokinetics and Mechanism of Action." Current Pharmaceutical Design 24, no. 6 (May 10, 2018): 659–63. http://dx.doi.org/10.2174/1381612824666180123110042.

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Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family Colchicum autumnale, sometimes called the “autumn crocus”. It is predominantly metabolized in the gastrointestinal tract. Two proteins, P-glycoprotein (P-gp) and CYP3A4 seem to play a pivotal role, governing its pharmacokinetic. The commonest side effects are gastrointestinal (nausea, vomiting and particularly dose-related-diarrhea) occurring in 5-10% of patients. Colchicine exerts its unique action mainly through inhibition of microtubule polymerization. Microtubule polymerization affects a variety of cellular processes including maintenance of shape, signaling, division, migration, and cellular transport. Colchicine interferes with several inflammatory pathways including adhesion and recruitment of neutrophils, superoxide production, inflammasome activation, the RhoA/Rho effector kinase (ROCK) pathway and the tumor necrosis factor alpha (TNF-α) -induced nuclear factor κΒ (NF-κΒ) pathway attenuating the inflammatory response. This concise paper attempts to give a brief review of its pharmacokinetic properties and its main mechanisms of action.

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Mróz, Lucyna. "Variation in stage structure and fitness traits between road verge and meadow populations of Colchicum autumnale (Liliaceae): Effects of habitat quality." Acta Societatis Botanicorum Poloniae 75, no. 1 (2011): 69–78. http://dx.doi.org/10.5586/asbp.2006.010.

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The frequency distribution and density of three life stages as well as fitness components of the perennial plant <em>Colchicum autumnale</em> growing in the unmanaged road verges and in the extensive mown and grazed meadows in the Sudeten Mts. were studied. Furthermore, investigated were the effects of population size and plant size (measured as number of flowers) on reproductive success and explored if variation in reproductive and vegetative traits of adults could be associated with soil characteristics. The t-test indicated that proportions of subadults and reproductive adults were significantly lower in verge than in meadow populations, and of vegetative adults significantly higher. The plant density of reproductive adults and the reproductive adults to all adults ratio were significantly lower in verge populations compared to meadow populations. Although habitat type accounted for significant variation in stage structure, no significant difference was found between vegetative and reproductive traits in adult plants, except for the number of flowers. In verge populations the number of flowers was significantly lower as compared to meadow populations. The traits related to reproduction were not significantly influenced by population size. However, the proportion of flowers setting fruit decreased significantly with increasing number of flowers. The stepwise multiple regression revealed significant relationships between soil characteristics and number of fruits per plant, fruit set, number seeds per plant and number of leaves in vegetative adults. The results suggest that the creation of the low and relatively open vegetation cover could increase the chance of persistence of <em>C. autumnale</em> living in verge habitats by promoting of seed germination, seedling establishment and flowering, and they also show that the reproductive success and vegetative components of fitness are most likely influenced by habitat quality.

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Kupper, Jacqueline, Katharina Rentsch, Andreas Mittelholzer, Romana Artho, Sven Meyer, Hugo Kupferschmidt, and Hanspeter Naegeli. "A Fatal Case of Autumn Crocus (Colchicum Autumnale) Poisoning in a Heifer: Confirmation by Mass-Spectrometric Colchicine Detection." Journal of Veterinary Diagnostic Investigation 22, no. 1 (January 2010): 119–22. http://dx.doi.org/10.1177/104063871002200125.

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Lin, Sukun, Deqiang Qin, Yue Zhang, Qun Zheng, Liupeng Yang, Dongmei Cheng, Suqing Huang, Jianjun Chen, and Zhixiang Zhang. "Toxicity and Sublethal Effects of Autumn Crocus (Colchicum autumnale) Bulb Powder on Red Imported Fire Ants (Solenopsis invicta)." Toxins 12, no. 11 (November 21, 2020): 731. http://dx.doi.org/10.3390/toxins12110731.

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Autumn crocus (Colchicum autumnale L.) is a medicinal plant as it contains high concentrations of colchicine. In this study, we reported that the ground powder of autumn crocus bulb is highly toxic to invasive Solenopsis invicta Buren, commonly referred to as red imported fire ants (RIFAs). Ants fed with sugar water containing 5000 mg/L of bulb powder showed 54.67% mortality in three days compared to 45.33% mortality when fed with sugar water containing 50 mg/L of colchicine. Additionally, the effects of short-term feeding with sugar water containing 1 mg/L of colchicine and 100 mg/L of autumn crocus bulb powder were evaluated for RIFAs’ colony weight, food consumption, and aggressiveness, i.e., aggregation, grasping ability, and walking speed. After 15 days of feeding, the cumulative colony weight loss reached 44.63% and 58.73% due to the sublethal concentrations of colchicine and autumn crocus bulb powder, respectively. The consumption of sugar water and mealworm (Tenebrio molitor L.) was substantially reduced. The aggregation rates decreased 48.67% and 34.67%, grasping rates were reduced to 38.67% and 16.67%, and walking speed decreased 1.13 cm/s and 0.67 cm/s as a result of the feeding of the two sublethal concentrations of colchicine and autumn crocus bulb powder, respectively. Our results for the first time show that powder derived from autumn crocus bulbs could potentially be a botanical pesticide for controlling RIFAs, and application of such a product could be ecologically benign due to its rapid biodegradation in the environment.

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Danilovic, Milos, Jelena Isailovic, Ivan Aleksic, Jelena Dzambas, and Nadica Marinkovic. "Accidental colchicine poisoning with fatal outcome after ingestion of meadow saffron (Colchicum autumnale L.) - Report of autopsy case." Vojnosanitetski pregled 77, no. 10 (2020): 1104–8. http://dx.doi.org/10.2298/vsp180413034d.

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Introduction. Meadow saffron (Colchicum autumnale L.) is a perennial herbaceous plant belonging to the Lily family (Liliacea). It is similar to the edible wild garlic (Allium ursinum L.). Toxic substance in meadow saffron is alkaloid colchicine. Colchicine poisoning is a very dangerous condition which can lead to a fatal outcome. Case report. A 50-yearsold male was addmited to the hospital complaining of weakness, abdominal pain, nausea, vomiting and diarrhea without blood. The day before, the patient ate two plants thinking they were wild garlic and seven hours after ingestion he felt first symptoms. During the course of the hospital stay, he had gastroenterocolitis, acute renal faliure, hepatic lesions and cardiorespiratory insufficiency with a fatal outcome. Post-mortem examination revealed: brain oedema, lung oedema and congestion, heart weighing 700 g with ventricular hypertrophy, myocardial fibrosis, liver congestion and steatosis, spleen congestion, pancreatic fibrosis. Organs sections were taken for histopathological analysis. Body fluids and parts of organs were toxicologically analyzed. Histopathological findings were: brain oedema, diffuse perivascular and interstitial myocardial fibrosis, myocardial haemorrhage, lungs congestion and oedema, microvesicular and macrovesicular liver steatosis, centrilobular liver necrosis, lymphocytic inflammatory infiltrate in liver portions, red pulp congestion of the spleen, kidney congestion and interstitial bleeding, coagulation necrosis of the proximal tubules of the kidney. Toxicological analysis showed colchicine in the blood ? 0.011 mg/L, urine ? 0.051 mg/L, liver with gallbladder ? 0.007 mg/kg, kidney ? 0.008 mg/kg. Conclusion. Ingestion of meadow saffron can lead to poisoning with a fatal outcome due to the presence of the alkaloid colchicine. Colchicine intoxication should be suspected in patients with gastrointestinal symptoms after consuming wild plants.

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Mróz, Lucyna. "Between-population variation in plant performance traits and elemental composition of Colchicum autumnale L. and its relation to edaphic environments." Acta Societatis Botanicorum Poloniae 77, no. 3 (2011): 229–39. http://dx.doi.org/10.5586/asbp.2008.029.

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Variation in vegetative and reproductive performance and leaf mineral composition among 25 populations of <em>Colchicum autumnale</em> (meadow saffron) from soils derived from six parent materials (limestone, marl, sandstone, greenstone, melaphyre and serpentine) in southwestern Poland has been investigated. The plant size (PS), total le-af area (TLA), leaf shape (LS), number of fruits per plant (NFP), number of seeds per plant (NFP), total weight seed per plant (TWSP) were estimated, and concentrations of seventeen elements (N, P, K, Ca, Mg, Na, S, Fe, Mn, Cu, Zn, Pb, Cd, Ni, Co, Cr, Mo) were analyzed in leaf and soil samples. In soil samples, also soil pH, organic matter content and sand, silt and clay content were determined. All soils (except melaphyre soil) contained elevated levels of Cr. Concentrations of soil Ni and Zn, Pb, Cd in serpentinite soil and polluted marl soils (respectively) were significantly higher than those of other examined soils. Meadow saffron leaves from all sites (except marl sites) contained elevated levels of Cr, Co and Ni. Statistical analysis, carried out with principal component analysis (PCA) revealed that a good correlation exists between the element content in leaves and plant performance traits and soil environment. The leaf Ca content and NFP were correlated and were much higher in populations from metal (except Cr) and nutrient-poor marl soils than in those from metal (except Ni in serpentine soil)and nutrient moderate rich soils derived from melaphyre, greenstones, serpentinite, limestones and sandstones and in those from metal-rich and nutrient-poor polluted marl soils. Meadow saffron plants tended to take up higher amounts of N, P, K, Mn, Cu and Na and lower amounts of S and had much higher TLA in populations from sandstone soils than those in populations from serpentinite, melaphyre, greenstone, marl and limestone soils. The leaf Co, Ni, Cr, Mg concentrations were correlated and were much higher in populations from serpentinite, melaphyre, greenstone, polluted marl and limestone soils than those from marl and sandstone soils. The pattern of variation in NFP and TLA across the different soil types was the opposite of that for leaf N, Cu, Na, Ni, Mg and S concentrations. Redundancy analysis (RDA) enables identification of the soil variables that best explain the variance pattern of plant response. The variation explained by the soil variables (15 soil elements and soil pH) was high (79%). The forward selection of soil variables identified soil Co, Mo, Ni, Ca and Zn concentrations as significantly influencing the ordination plant traits. The variation explained by these selected variables was 55%. Thus the five soil variables appeared to be the main factors determining the pattern variation of vegetative, reproductive and nutrient traits of <em>Colchicum autumnale</em>.

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Widden, Paul. "The morphology of vesicular – arbuscular mycorrhizae in Clintonia borealis and Medeola virginiana." Canadian Journal of Botany 74, no. 5 (May 1, 1996): 679–85. http://dx.doi.org/10.1139/b96-086.

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During a survey of the vesicular–arbuscular mycorrhizal (VAM) associations of forest herbs in a deciduous forest in the southern Laurentian mountains in Quebec, two liliaceous species, Clintonia borealis and Medeola virginiana, revealed very distinctive morphology. In both species, once the epidermis was penetrated, the fungus spread towards the centre of the root via intracellular hyphae until the innermost layer of the cortex was reached, at which point the fungus spread laterally and tangentially through the cortical cells adjacent to the endodermis via a series of banana-shaped projections (bobbits). These eventually differentiated into the arbuscules and the VAM might spread from this inner cortical layer back into the outer cortical layers. In C. borealis, the hyphae coiled in the cortex, and vesicles were formed in the upper cortical cells. In M. virginiana, no coiling took place, but extensive diverticulae were produced by the intracellular hyphae in the cortical cells, close to their point of exit, and vesicles were produced in the inner cortex as swellings from the bobbits. These two mycorrhizae have some similarities to one in Colchicum autumnale described by I. Gallaud (1905. Rev. Gen. Bot. 17). Keywords: vesicular–arbuscular mycorrhizae, Clintonia borealis, Medeola virginiana, Liliaceae, morphology.

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