Relevant bibliographies by topics / Colibactin

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Academic literature on the topic 'Colibactin'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 May 2024

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Journal articles on the topic "Colibactin"

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Dougherty, Michael W., Rafael Valdés-Mas, Kevin M. Wernke, et al. "Abstract 1215: Synthetic colibactins reveal the structural and biological mode-of-action of a microbial carcinogen." Cancer Research 83, no. 7_Supplement (2023): 1215. http://dx.doi.org/10.1158/1538-7445.am2023-1215.

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Abstract Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin, that putatively alkylates host DNA via nucleophilic cyclopropane ring addition. While evidence suggests colibactin’s genotoxicity promotes mutagenesis and cancer, it has been impossible to directly test this hypothesis due to compound instability and sparse production. Recently synthesized stable colibactin analogs facilitate the first studies investigating the compounds structural mode of action. We tested the genotoxic cap
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Sogari, Alberto, Emanuele Rovera, Nicole Megan Reilly, et al. "Abstract 5900: Tolerance to colibactin correlates with response to chemotherapeutic agents in colorectal cancer." Cancer Research 83, no. 7_Supplement (2023): 5900. http://dx.doi.org/10.1158/1538-7445.am2023-5900.

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Abstract Introduction: The bacterial genotoxin colibactin is enriched in colorectal cancer (CRC) and promotes the accumulation of mutations that drive tumorigenesis. However, systematic assessment of its impact on DNA damage response is lacking and the effect of colibactin exposure on response to other genotoxic agents (such as chemotherapy) is missing. Materials and Methods: We implemented an in vitro bacteria-coculture system to assess the effect of colibactin on a representative subset of 40 molecularly and pharmacologically annotated CRC cell lines and in a panel of isogenic DDR KO cell li
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Sogari, Alberto, Emanuele Rovera, Nicole Megan Reilly, et al. "Abstract B005: Tolerance to colibactin correlates with response to chemotherapeutic agents in colorectal cancer." Cancer Research 84, no. 1_Supplement (2024): B005. http://dx.doi.org/10.1158/1538-7445.dnarepair24-b005.

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Abstract Introduction. The bacterial genotoxin colibactin is enriched in colorectal cancer (CRC) and promotes the accumulation of mutations that drive tumorigenesis. However, systematic assessment of its impact on DNA damage response is lacking and the effect of colibactin exposure on response to other genotoxic agents (such as chemotherapy) is missing. Materials and methods: We implemented an in vitro bacteria-coculture system to assess the effect of colibactin on a representative subset of 40 molecularly and pharmacologically annotated CRC cell lines and in a panel of isogenic DDR KO cell li
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Wilson, Matthew R., Yindi Jiang, Peter W. Villalta, et al. "The human gut bacterial genotoxin colibactin alkylates DNA." Science 363, no. 6428 (2019): eaar7785. http://dx.doi.org/10.1126/science.aar7785.

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Certain Escherichia coli strains residing in the human gut produce colibactin, a small-molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects have remained unknown for more than a decade. Here we combine an untargeted DNA adductomics approach with chemical synthesis to identify and characterize a covalent DNA modification from human cell lines treated with colibactin-producing E. coli. Our data establish that colibactin alkylates DNA with an unusual electrophilic cyclopropane. We sho
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Dougherty, Michael W., and Christian Jobin. "Shining a Light on Colibactin Biology." Toxins 13, no. 5 (2021): 346. http://dx.doi.org/10.3390/toxins13050346.

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Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease and colorectal cancer. E. coli harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental knowledge regarding colibactin function is lacking. To accurately assess the role of pks+ E. coli in cancer etiology, the biological mechanisms governing production and delivery of co
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Silpe, Justin E., Joel W. H. Wong, Siân V. Owen, Michael Baym, and Emily P. Balskus. "The bacterial toxin colibactin triggers prophage induction." Nature 603, no. 7900 (2022): 315–20. http://dx.doi.org/10.1038/s41586-022-04444-3.

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AbstractColibactin is a chemically unstable small-molecule genotoxin that is produced by several different bacteria, including members of the human gut microbiome1,2. Although the biological activity of colibactin has been extensively investigated in mammalian systems3, little is known about its effects on other microorganisms. Here we show that colibactin targets bacteria that contain prophages, and induces lytic development through the bacterial SOS response. DNA, added exogenously, protects bacteria from colibactin, as does expressing a colibactin resistance protein (ClbS) in non-colibactin
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Xue, Mengzhao, Chung Sub Kim, Alan R. Healy, et al. "Structure elucidation of colibactin and its DNA cross-links." Science 365, no. 6457 (2019): eaax2685. http://dx.doi.org/10.1126/science.aax2685.

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Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. The presence of colibactin-producing bacteria correlates with the frequency and severity of colorectal cancer in humans. However, because colibactin has not been isolated or structurally characterized, studying the physiological effects of colibactin-producing bacteria in the human gut has been difficult. We used a combination of genetics, isotope labeling, tandem mass spectrometry, and chemical synthesis to deduce the structure of colibactin. Our structural assignment accounts for all known b
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Hallam, Jennifer C., Sofia Sandalli, Iris Floria, et al. "D-Serine reduces the expression of the cytopathic genotoxin colibactin." Microbial Cell 10, no. 3 (2023): 63–77. http://dx.doi.org/10.15698/mic2023.03.793.

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Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability. Production of colibactin has been implicated in the devel-opment of colorectal cancer (CRC). In this study, we demonstrate the inhibito-ry effect of D-Serine on the expression of the pks island in both prototypic and clinically-associated colibactin-producing strains and determine the implications for cytopathic effects on host cells. We also
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Nougayrede, J. P. "The genotoxin colibactin." Toxicon 116 (June 2016): 74–75. http://dx.doi.org/10.1016/j.toxicon.2016.01.012.

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Meng, Xia, Yanfei Chen, Peili Wang, et al. "Phosphopantetheinyl transferase ClbA contributes to the virulence of avian pathogenic Escherichia coli in meningitis infection of mice." PLOS ONE 17, no. 7 (2022): e0269102. http://dx.doi.org/10.1371/journal.pone.0269102.

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Avian pathogenic Escherichia coli (APEC), which has potential zoonotic risk, can cause severe systemic infections such as septicemia and meningitis in poultry. Colibactin is a hybrid non-ribosomal peptide/polyketide secondary metabolite produced by bacteria, which induces double-strand DNA breaks and chromosome instability in eukaryotic cells. ClbA is a 4’-phosphopantetheinyl transferase (PPTase) that is essential for colibactin and plays a role in siderophore synthesis. However, whether ClbA is associated with meningitis development in APEC is unclear. In this study, we abolished the clbA gen
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Dissertations / Theses on the topic "Colibactin"

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Cougnoux, Antony. "Escherichia Coli producteurs de colibactine et croissance tumorale, du mécanisme à la prévention." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM01/document.

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La colibactine est une toxine largement distribuée chez Escherichia coli. Sa synthèse est assurée par des enzymes codés par un îlot génomique appelé pks. Elle provoque des cassures double brin de l'ADN, des mutations, d'important remaniements chromosomiques et favorise l'émergence de tumeurs intestinales en modèle murin. Par ailleurs, les E. coli producteurs colonisent fréquemment les tumeurs de patients atteints de cancer colorectal. Nos travaux montrent que les bactéries productrices de colibactine induisent la sénescence cellulaire et stimulent de façon indirect la prolifération cellulaire
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Garcie, Christophe. "Modulation atypique de la biosynthèse de la colibactine, une génotoxine de Escherichia coli, ou comment un îlot génomique est en symbiose avec le chromosome bactérien." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30283/document.

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L'îlot génomique pks code une machinerie de biosynthèse complexe synthétisant la colibactine, une génotoxine produite par certaines souches de Escherichia coli. Cette génotoxine induit des cassures double-brin de l'ADN sur les cellules eucaryotes in vitro et in vivo. La colibactine n'est pas une protéine, mais un métabolite secondaire de type polycétide/peptide non-ribosomal (PK/NRP). Des résultats préliminaires de l'équipe semblaient indiquer que certains gènes du core genome de E. coli seraient également impliqués dans la production de la colibactine. L'objectif de cette thèse était d'identi
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Tronnet, Sophie. "Régulation par le fer et rôle de la colibactine dans la colonisation du tube digestif par Escherichia coli." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30062/document.

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Le microbiote intestinal joue un rôle majeur dans le développement des fonctions digestive, métabolique, immunitaire et neurologique de son hôte. Escherichia coli est un hôte commun de la microflore commensale intestinale de l'Homme et des animaux à sang chaud, et s'établit dans le tractus digestif dès les premières heures ou jours qui suivent la naissance. L'espèce E. coli, bactérie anaérobe facultative prévalente, peut être divisée en sept groupes phylogénétiques principaux. Le groupe phylogénétique B2 comprend le plus grand nombre de souches responsables d'infections extra-intestinales (mén
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Lucas, Cécily. "Rôle de l'autophagie dans la réponse de l'hôte suite à l'infection par des Escherichia Coli producteurs de colibactine isolés de patients atteints d'un cancer colorectal." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAS016/document.

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La muqueuse des patients atteints de cancer colorectal (CCR) est anormalement colonisée par des souches d’Escherichia coli porteuses de l’îlot pathogène pks (E. coli/pks+), responsable de la synthèse de la génotoxine colibactine. Les E. coli/pks+ induisent des cassures double brin de l’ADN, l’accumulation d’aberrations chromosomiques ainsi que la sénescence, et favorisent le développement tumoral dans des modèles murins de CCR. L’autophagie est un processus des cellules eucaryotes qui permet la dégradation d’éléments cytoplasmiques par les lysosomes et est activé pour permettre l’adaptation de
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Corelli, Barbara. "Investigation of Klebsiella virulence : the role of capsule in Klebsiella rhinoscleromatis pathogenesis and characterization of a Klebsiella pneumoniae capsule mutant unable to produce colibactin toxin." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC265/document.

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L’émergence et la dissémination récentes de clones hypervirulents et multi-résistants de Klebsiella pneumoniae ont renouvelé l'intérêt général envers Klebsiella. Cependant, notre connaissance de la pathogénèse de Klebsiella au niveau moléculaire et cellulaire reste faible. Dans ce travail, nous avons mené deux axes de recherche focalisés sur la pathogénèse de Klebsiella. Le premier projet visait à caractériser un mutant de capsule de K. pneumoniae incapable de produire une toxine colibactine fonctionnelle. La colibactine est un métabolite secondaire génotoxique produit principalement par des s
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Brotherton, Carolyn Adams. "Investigations of the Biosynthesis and Structure of Colibactin, a Cytotoxin Made by Human-Associated Escherichia Coli." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718729.

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Humans exist in symbiosis with trillions of bacteria that are collectively referred to as the human microbiota. While commensal microbes are essential for health, some resident microbes can promote disease. Certain strains of human-associated Escherichia coli cause double-strand breaks in host DNA through the production of colibactin, a genotoxin of unknown structure. To broaden our understanding of the chemistry of the human microbiota, we sought to elucidate the structure of colibactin and characterize its biosynthetic pathway. We first characterized the self-resistance mechanism in colibact
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Massip, Clémence. "Rôle de l'îlot génomique pks dans la synthèse des sidérophores-microcines chez Escherichia coli." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30163.

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Les sidérophores-microcines H47 et M (MccH47 et MccM) sont des peptides antimicrobiens hybrides, constitués d'une entité peptidique couplée à un groupement dérivé d'un sidérophore, l'entérobactine. Elles sont à l'origine de l'activité antagoniste de la souche Escherichia coli Nissle (EcN) vis-à-vis d'entérobactéries pathogènes. Cette souche est également porteuse de l'îlot pks à l'origine de la synthèse d'une génotoxine, la colibactine. Nous avons déterminé que la peptidase ClbP codée par l'îlot pks était indispensable à la synthèse des sidérophores-microcines chez EcN. C'est la partie C-termi
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Dubois, Damien. "L'ilot génomique pks chez Escherichia coli : structure-fonction de la protéine ClbP et études épidémiologiques." Phd thesis, Université d'Auvergne - Clermont-Ferrand I, 2011. http://tel.archives-ouvertes.fr/tel-00612631.

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L'ilot génomique pks de Escherichia coli et d'autres Enterobacteriaceae code des synthases depolycétides et de peptides non ribosomaux qui permettent l'assemblage d'un composé hybride polycétidepeptidenon ribosomal putative. Ce composé nommé colibactine induit des cassures double-brin de l'ADN descellules eucaryotes.La machinerie enzymatique codée par l'ilot pks comporte une protéine essentielle ClbP, atypique dansce type d'ilot. Nous avons montré que ClbP possède une partie N-terminale catalytique et périplasmique, et unepartie C-terminale associée à la membrane cytoplasmique. La structure cr
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Silva, Patricia Vollú. "Virulência em Escherichia Coli uropatogênicas e Klebsiella Pneumoniae associadas à bacteremia portadoras ou não da ilha pks e papel de Colibactin e Enterobactin na patogênese de infecções por K. Pneumoniae." Niterói, 2018. https://app.uff.br/riuff/handle/1/5561.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2018-01-22T12:47:14Z No. of bitstreams: 1 PATRICIA VOLLÚ SILVA.PDF: 2575547 bytes, checksum: c2489f8abe58d46ea1c2ba8977ba02e1 (MD5)<br>Made available in DSpace on 2018-01-22T12:47:14Z (GMT). No. of bitstreams: 1 PATRICIA VOLLÚ SILVA.PDF: 2575547 bytes, checksum: c2489f8abe58d46ea1c2ba8977ba02e1 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A ilha de patogenicidade pks de 54 kb é responsável pela produção de colibactin, uma molécula genotóxica, que causa rupturas de fita dupla de DNA (DSB) das cél
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Bossuet, Nadège. "Étude de la production de colibactine par Escherichia coli en fonction de la concentration en oxygène." Electronic Thesis or Diss., Toulouse 3, 2023. http://www.theses.fr/2023TOU30322.

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Escherichia coli est une bactérie anaérobie facultative commune du microbiote intestinal de l'Homme. Certaines souches de E. coli peuvent être porteuses de l'ilot génomique pks codant pour une machinerie de biosynthèse produisant une génotoxine nommée la colibactine. L'ilot pks est régulé par différents facteurs environnementaux participant au métabolisme de la bactérie tels que le fer, les sources de carbone ou les polyamines. Dans l'intestin, la faible concentration en oxygène est un élément clé qui contribue à l'équilibre des populations microbiennes avec une majorité de bactéries anaérobie
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Book chapters on the topic "Colibactin"

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"Peptide Natural Products II: Nonribosomal Peptides." In Natural Product Biosynthesis. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/bk9781839165641-00150.

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Peptide natural products assembled by nonribosomal peptide synthetase (NRPS) machinery activate proteinogenic and nonproteinogenic amino acids, install them as thioesters tethered to phosphopantetheinyl prosthetic groups on peptidyl carrier protein domains, and carry out chain elongations by amide bond formations. The growing peptidyl chain, as a series of elongating peptidyl thioesters, is released when it reaches the most downstream NRPS assembly-line module, typically by either hydrolysis, macrolactonization/macrolactamization, reductive elimination, or Dieckmann condensation. A series of dedicated tailoring enzymes act both on assembly lines or as post-assembly-line tailoring catalysts to morph the peptide backbone and side chains into compact, hydrolysis-resistant linear and cyclic end products. NRPS assembly lines build the aminoadipyl-cysteinyl-d-valine tripeptide, which is then bis-cyclized to the 4,5-fused ring system of lactam antibiotics, as well as the heptapeptide scaffold of vancomycin-type glycopeptide antibiotics. Additional nonribosomal peptide biosynthesis products analyzed include didemnin, kutzneride, tyrocidine, polymyxin, ADEPs, daptomycin, enterobactin, yersiniabactin, echinocandin, and obafluorin. Hybrid nonribosomal peptide-polyketide assembly lines lead to rapamycin, bleomycin, and colibactin.
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Conference papers on the topic "Colibactin"

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Lumish, Melissa A., Anisha Luthra, Simran Asawa, et al. "Abstract 611: Colibactin mutation signatures are associated with a distinct colorectal cancer clinicopathologic phenotype." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-611.

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Lopes, A., AH Casse, J. Veziant, et al. "32 Impact of colibactin-producing escherichia coli on immune microenvironment in preclinical colorectal cancer models." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.32.

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Oliero, Manon, Roy Hajjar, Thibault Cuisinière, et al. "IDDF2022-ABS-0217 Inulin promotes the growth of tumorigenic colibactin-producing bacteria in APCMIN/+ mice." In Abstracts of the International Digestive Disease Forum (IDDF), Hong Kong, 2–4 September 2022. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2022. http://dx.doi.org/10.1136/gutjnl-2022-iddf.68.

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