Academic literature on the topic 'Colistin sulfate'
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Journal articles on the topic "Colistin sulfate":
Solanki, Neel R., Deepa H. Patel, and Dipali R. Talele. "Dextran Microparticulate Inhalable Dry Powder for the Treatment of Cystic Fibrosis and Mucopolysaccharidosis." Current Drug Delivery 17, no. 3 (April 26, 2020): 218–28. http://dx.doi.org/10.2174/1567201817666200122160110.
Minagawa, Shun, Yasumitsu Kondoh, Keigo Sueoka, Hiroyuki Osada, and Hitoshi Nakamoto. "Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity." Biochemical Journal 435, no. 1 (March 15, 2011): 237–46. http://dx.doi.org/10.1042/bj20100743.
PÉrez-Lozano, Pilar, Encarna GarcÍa-Montoya, Anna Orriols, Montse MiÑarro, Josep Ramon TicÓ, and Josep Maria SuÑÉ-Negre. "Application of a Validated Method in the Stability Study of Colistin Sulfate and Methylparaben in a Veterinary Suspension Formulation by High-Performance Liquid Chromatography with a Diode Array Detector." Journal of AOAC INTERNATIONAL 90, no. 3 (May 1, 2007): 706–14. http://dx.doi.org/10.1093/jaoac/90.3.706.
Li, Jian, Robert W. Milne, Roger L. Nation, John D. Turnidge, Timothy C. Smeaton, and Kingsley Coulthard. "Use of High-Performance Liquid Chromatography To Study the Pharmacokinetics of Colistin Sulfate in Rats following Intravenous Administration." Antimicrobial Agents and Chemotherapy 47, no. 5 (May 2003): 1766–70. http://dx.doi.org/10.1128/aac.47.5.1766-1770.2003.
Kroeger, Lisa A., Laurie B. Hovde, Isaac F. Mitropoulos, Jeremy Schafer, and John C. Rotschafer. "Colistin Methanesulfonate against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacodynamic Model." Antimicrobial Agents and Chemotherapy 51, no. 9 (June 18, 2007): 3431–33. http://dx.doi.org/10.1128/aac.01433-06.
Fouad, Ali, Montaser Shaykoon, Samy Ibrahim, Sobhy El-Adl, and Ashraf Ghanem. "Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography." Molecules 24, no. 5 (February 26, 2019): 833. http://dx.doi.org/10.3390/molecules24050833.
Jin, Liang, Jian Li, Roger L. Nation, and Joseph A. Nicolazzo. "Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice." Antimicrobial Agents and Chemotherapy 55, no. 2 (November 29, 2010): 502–7. http://dx.doi.org/10.1128/aac.01273-10.
Azzopardi, Ernest A., Elaine L. Ferguson, and David W. Thomas. "Development and Validation of anIn VitroPharmacokinetic/Pharmacodynamic Model To Test the Antibacterial Efficacy of Antibiotic Polymer Conjugates." Antimicrobial Agents and Chemotherapy 59, no. 4 (December 15, 2014): 1837–43. http://dx.doi.org/10.1128/aac.03708-14.
Albur, Mahableshwar, Alan Noel, Karen Bowker, and Alasdair MacGowan. "Bactericidal Activity of Multiple Combinations of Tigecycline and Colistin against NDM-1-Producing Enterobacteriaceae." Antimicrobial Agents and Chemotherapy 56, no. 6 (March 5, 2012): 3441–43. http://dx.doi.org/10.1128/aac.05682-11.
Stanzani, Marta, Fabio Tumietto, Maria Benedetta Giannini, Giuseppe Bianchi, Anna Nanetti, Nicola Vianelli, Mario Arpinati, et al. "Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline." Journal of Medical Microbiology 56, no. 12 (December 1, 2007): 1692–95. http://dx.doi.org/10.1099/jmm.0.47286-0.
Dissertations / Theses on the topic "Colistin sulfate":
Cortés-Kaplan, Serena. "A Small Molecule Drug Screening Identifies the Antibiotic Colistin Sulfate as an Enhancer of NK Cell Cytotoxicity." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42547.
Bressan, Cléo Rodrigo. "Toxicidade do antibiótico sulfato de colistina empregado na suinocultura sobre processos microbiológicos relacionados ao tratamento de efluentes." reponame:Repositório Institucional da UFSC, 2012. https://repositorio.ufsc.br/handle/123456789/106752.
Made available in DSpace on 2013-12-05T22:14:50Z (GMT). No. of bitstreams: 1 317849.pdf: 2943550 bytes, checksum: 36518aec46632ea3bd10be270a250573 (MD5) Previous issue date: 2012
O modelo atualmente empregado de produção intensiva de suínos implica na utilização de grande quantidade de antimicrobianos para manter a sanidade do rebanho, os quais são utilizados tanto de forma terapêutica como também na forma de promotores de crescimento, neste último caso empregado de forma contínua e em concentrações mais reduzidas que quando utilizado como agente terapêutico. Muitos destes agentes antimicrobianos chegam aos sistemas de tratamento de dejetos ainda sob sua forma ativa, podendo interferir nos processos microbianos envolvidos no tratamento. Os efeitos destes agentes antimicrobianos sobre as comunidades microbianas relacionadas ao tratamento dos efluentes são ainda pouco conhecidos. Este trabalho tem como objetivo geral investigar a toxicidade do antibiótico sulfato de colistina sobre a microbiota nitrificante e metanogênica, os quais são grupos considerados bons indicadores de toxicidade e responsáveis por etapas importantes em sistemas de tratamento de efluentes aeróbios e anaeróbios, respectivamente. Análises de toxicidade aguda revelaram que a colistina possui toxicidade relevante apenas sobre o grupo das bactérias oxidadoras de amônia (BOA), possuindo muito pouca atividade sobre as bactérias oxidadoras de nitrito (BON). Os testes de toxicidade crônica sobre a nitrificação apresentaram resultados similares aos obtidos nos experimentos de toxicidade aguda em relação às concentrações da CI50, com concentrações da ordem de 60 a 70 mg colistina.L-1, porém em concentrações mais elevadas a toxicidade crônica mostrou-se mais severa que a aguda. As concentrações inibitórias encontradas para o grupo das BOA são da mesma ordem de grandeza que aquelas propostas para uso na água como agente terapêutico, sugerindo que nestes casos a colistina poderia representar riscos potenciais para a operação estável de processos de nitrificação, uma vez que a colistina é eliminada pelas fezes quase totalmente sob a forma inalterada. Os testes de toxicidade crônica sobre as arqueas metanogênicas, realizados em reator do tipo UASB, não evidenciaram qualquer toxicidade da colistina sobre este grupo.
Abstract: Intensive pig farming currently employed involves the use of a large quantity of antimicrobial agents to keep the herd healthy, being used both as therapeutic agents and also as growth promoters, in this latter case used on a continuous basis and also in lower concentrations than when used for therapeutic purposes. Many of these antimicrobial agents get to the wastewater treatment system still in their active forms, and as such they can interfere with the microbial processes involved in the treatment. The effects of these antimicrobial agents on the microbial communities related to wastewater treatment are still not well known. The main aim of this work is to investigate the toxicity of the antibiotic colistin sulfate on the nitrifying and methanogenic microbiota, groups that are considered good indicators of toxicity and also responsible for important biological process within aerobic and anaerobic treatment systems, respectively. Analyses of acute toxicity have shown that colistin has relevant toxicity only on the group of ammonia-oxidizing bacteria (AOB), but have very little activity in relation to nitrite oxidizing bacteria (NOB). Tests of chronic toxicity on nitrification have shown results similar to those obtained in acute toxicity experiments in relation to concentrations of the CI50, with concentrations between 60 and 70 mg.L-1 of colistin, but at higher concentrations the chronic toxicity showed to be more severe than the acute toxicity. The inhibitory concentrations found for the AOB group are at the same order of magnitude as those proposed for use in water as therapeutic agent, suggesting that in these cases colistin could pose a possible risk for the stable operation of nitrification processes, as colistin is eliminated in the faeces almost entirely in unaltered form. The chronic toxicity tests on methanogenic archaea, carried out in a UASB reactor, did not show any toxic effect of colistin on this group.
Rhouma, Mohamed. "Évaluation in vivo de l’efficacité thérapeutique, de la résistance et la pharmacocinétique de la colistine sulfate lors du traitement de la diarrhée colibacillaire post sevrage chez le porc." Thèse, 2016. http://hdl.handle.net/1866/18587.
Post-weaning diarrhea (PWD) caused by Escherichia coli is an endemic intestinal infection in pig farms worldwide. This disease is mostly the consequence of the presence and the multiplication in piglet’s gut of an Escherchia pathotype, named enterotoxigenic E. coli (ETEC) and in particular those that express the F4 (K88) fimbrial adhesin (ETEC: F4). The predominant serogroup of E. coli isolated from piglets with PWD worldwide is O149. Several studies have reported a significant resistance rate of O149 ETEC strains against commonly used antibiotics for the treatment of PWD, particularly, aminoglycosides. Thereby, to address therapeutic failures observed in pig farms during PWD treatment, veterinarians in Canada started using, under their responsibilities, the colistin sulfate (CS), an antibiotic not approved for farm animals in Canada. The objectives of this thesis were: to study the pharmacokinetics of CS in vitro and in vivo, to develop a sensitive method for the quantification of CS plasma concentrations in pigs, to determine the therapeutic efficacy of CS in an experimental model of PWD, and to characterize the resistance of E. coli to colistin consecutive to its therapeutic use in pigs. Simulated gastric fluid (SGF) was prepared, and after the addition of CS and pepsin to this solution, the concentrations of CS were followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). A rapid degradation of CS in the SGF was observed, and the degradation products showed a greater antimicrobial activity compared to the native CS. On the other hand, the experimental challenge of piglets with an ETEC: F4 strain has not increased the CS intestinal absorption in a subclinical model of PWD in pigs. The oral administration of a therapeutic dose of CS at 50,000 IU/kg twice a day for 5 successive days to treat an experimental PWD in pigs, resulted in a significant reduction of fecal ETEC: F4 and total E. coli shedding, and in diarrhea scores but only during the treatment period. However, CS treatment resulted in a slight increase in fecal shedding of CS resistant E. coli and did not prevent weight loss in challenged pigs. In addition, challenge with ETEC: F4 resulted in an increase of CS intestinal absorption in a clinical model of PWD. This study has generated, for the first time, scientific data regarding CS therapeutic efficacy, its pharmacokinetic and the selection of E. coli colistin resistant in an experimental model of PWD in pigs. It also challenged the economic relevance of increasing CS oral doses to accelerate the clinical recovery of pigs. Finally, it indicated that optimal housing conditions were without other predisposing factors, effective as CS in improving clinical symptoms of experimental PWD in pigs.
Conference papers on the topic "Colistin sulfate":
Rhouma, M., F. Beaudry, W. Thériault, N. Bergeron, S. Laurent-Lewandowski, J. M. Fairbrother, and A. Letellier. "Impacts of colistin sulfate on fecal Escherichia coli resistance and on growth performance of piglets in a post-weaning diarrhea model." In Safe Pork 2015: Epidemiology and control of hazards in pork production chain. Iowa State University, Digital Press, 2015. http://dx.doi.org/10.31274/safepork-180809-332.
Rhouma, M., W. Thériault, Nadia Bergeron, S. L. Lewandowski, J. M. Fairbrother, F. Beaudry, and Ann Letellier. "Oral colistin sulfate in pigs: pharmacokinetics and effect on fecal Escherichia coli excretion of weaned pigs challenged with Escherichia coli F4 (K88)." In 10th International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork. Iowa State University, Digital Press, 2013. http://dx.doi.org/10.31274/safepork-180809-950.